JPWO2020169719A5

JPWO2020169719A5 - Methods of Analyte Concentration Monitoring Using Harmonic Relationships

Info

Publication number: JPWO2020169719A5
Application number: JP2021549382A
Authority: JP
Publication date: 2023-03-01

Claims

A method of electronically probing redox reactions in an analyte-containing fluid, comprising:
applying a periodic voltage excitation signal to the analyte-containing fluid by a first circuit, wherein the periodic voltage excitation signal has a fundamental frequency;
generating, by a second circuit, an amperometric signal while the first circuit applies the periodic voltage excitation signal, the amperometric signal in the analyte-containing fluid; having a magnitude indicative of a current produced by a redox reaction, said magnitude depending, at least in part, on analyte concentration in said analyte-containing fluid;
sampling the current measurement signal by a third circuit;
providing, by the third circuit, digitized time domain sample data representing the current measurement signal;
extracting a plurality of harmonic signals based at least in part on the digitized time domain sample data, wherein the harmonic signals are harmonics of the fundamental frequency, each harmonic signal corresponding to having an intensity, wherein the set of harmonic relationships is based on one or more harmonic ratios;
calculating a set of harmonic relationships based at least in part on the plurality of harmonic signals;
accessing a harmonic relationship database, wherein the harmonic relationship database includes a plurality of harmonic relationship sets, each set of harmonic relationships being associated with a corresponding analyte concentration;
and determining a magnitude of analyte concentration in said analyte-containing fluid based on said harmonic relation database and said set of calculated harmonic relations.

2. The method of claim 1, further comprising generating power spectral density data from said digitized frequency domain data.

Accessing the harmonic relation database comprises:
2. The method of claim 1, comprising accessing a lookup table.

2. The method of claim 1, further comprising wirelessly transmitting the digitized time domain sample data representing the amperometric signal from a wearable continuous glucose monitoring device to a smart phone.

2. The method of claim 1, wherein sampling the current measurement signal comprises sampling at a first sampling rate ranging from 10 samples per second to 1000 samples per second for a first period of time.

6. The method of claim 5, wherein the first period of time ranges from 10 seconds to 300 seconds.

2. The claim 1, wherein the fundamental frequency of the periodic voltage excitation signal ranges from 0.1 Hz to 10 Hz and/or the amplitude of the periodic voltage excitation signal ranges from 150 millivolts to 500 millivolts. Method.

2. The method of claim 1, wherein said analyte-containing fluid comprises glucose.

2. The method of claim 1, wherein determining the magnitude of the analyte concentration in the analyte-containing fluid is performed by a wearable portion of an analyte monitoring system.

10. The method of Claim 9, further comprising displaying the analyte concentration on a display of the wearable portion.

2. The method of Claim 1, further comprising employing said calculated harmonic relationship to distinguish said analyte from at least one analyte interferent.

A continuous analyte monitoring (CAM) system comprising:
a first circuit configured to apply a periodic voltage excitation signal to the analyte-containing fluid;
A second circuit configured to generate an amperometric signal, wherein the amperometric signal has a magnitude indicative of a current in the analyte-containing fluid, wherein the magnitude is a second circuit that depends at least in part on the analyte concentration in the fluid;
a third circuit configured to sample the current measurement signal, the third circuit further configured to generate digitized time domain sample data;
A processor coupled to a memory, said memory having a stored harmonic relation database, and when executed by said processor, causing said processor to:
extracting a plurality of harmonic signals from the digitized time domain sample data, including converting the digitized time domain sample data to frequency domain data;
calculating a set of harmonic relationships based at least in part on the plurality of harmonic signals, wherein the set of harmonic relationships is based on one or more harmonic ratios;
accessing the harmonic relationship database, the harmonic relationship database comprising a plurality of harmonic relationship sets, each set of harmonic relationships being associated with a corresponding analyte concentration; and
determining the magnitude of the analyte concentration in the analyte-containing fluid based on the harmonic relationship database and the calculated set of harmonic relationships; and , a processor, and a continuous analyte monitoring (CAM) system.

13. The CAM system of claim 12, wherein said first circuit, said second circuit, and said third circuit are located on a wearable device.

14. The CAM system of claim 13, wherein said processor and said memory are located on said wearable device.

13. The CAM system of claim 12, wherein the instructions, when executed by the processor, cause the processor to further direct a wireless transmitter to transmit the analyte concentration.