JPWO2020151965A5

JPWO2020151965A5 -

Info

Publication number: JPWO2020151965A5
Application number: JP2021541449A
Authority: JP
Publication date: 2022-11-18
Anticipated expiration: 2040-01-13

Claims

A method of generating a non-invasive measurement of vascular stiffness in a subject, said method comprising:
acquiring 2D ultrasound data of a blood vessel from a first measurement location, said 2D ultrasound data providing information about movement of said blood vessel;
acquiring 3D ultrasound data of the blood vessel from the first measurement location, the 3D ultrasound data providing information representing a 3D geometry of the vessel, the 2D ultrasound data and the 3D ultrasound data is obtained from two separate ultrasound data acquisitions performed at the first measurement location ;
determining the motion of the vessel based on the motion of the vessel from the 2D ultrasound data;
obtaining a non-invasive blood pressure measurement from the subject;
providing the determined motion of the vessel, the 3D geometry of the vessel, and the non-invasive blood pressure measurement to a biomechanical model;
and generating stiffness measurements based on the biomechanical model.

The 2D ultrasound data comprises biplane ultrasound data, the biplane ultrasound data comprising:
a first data surface representing a first direction;
2. The method of claim 1, comprising a second data plane representing a second direction, said second direction being orthogonal to said first direction.

3. The method of any one of claims 1-2, wherein the 2D ultrasound data comprises a plurality of data planes each representing a different position along the length of the blood vessel, each data plane representing a cross-section of the blood vessel.

The method includes
obtaining further 2D ultrasound data and/or further 3D ultrasound data of the blood vessel from the second measurement location;
and comparing said 2D ultrasound data and/or 3D ultrasound data with said further 2D ultrasound data and/or further 3D ultrasound data. the method of.

The method further comprises generating a cine loop of the vessel based on the 2D ultrasound data, the cine loop comprising a plurality of ultrasound image frames of the vessel each acquired at a different point in time during a cardiac cycle. 5. The method of any one of claims 1-4, comprising:

The method includes
applying a tracking algorithm to the cineloop, thereby delineating an initial vessel boundary for at least one of the plurality of ultrasound image frames of the vessel;
determining a vessel boundary based on the initial vessel boundary for each of the plurality of ultrasound image frames;
6. The method of claim 5, further comprising determining vessel wall displacement over time based on the plurality of vessel boundaries.

7. The method of claim 6, wherein the method further comprises determining maximum vessel wall displacement and/or average vessel wall displacement based on the vessel wall displacement over time.

8. The method of claim 1, further comprising performing spatial registration on the acquired 2D ultrasound data, wherein acquiring the 3D ultrasound data is based on the spatial registration. The method according to any one of .

9. The method of any one of claims 1-8, wherein the method further comprises segmenting a representation of the 3D structure of the vessel from the 3D ultrasound data.

10. The method of any one of claims 1-9, wherein the non-invasive blood pressure measurement comprises a brachial pressure index.

Generating a stiffness measure based on the biomechanical model comprises:
generating a test vessel stiffness;
simulating a test motion of the vessel based on the test vessel stiffness;
comparing the test motion of the blood vessel to the measured motion of the blood vessel;
selecting the test vessel stiffness as a measure of the stiffness if the test motion of the blood vessel matches the measured motion of the blood vessel;
11. A method according to any preceding claim, comprising adjusting the test vessel stiffness if the test motion of the blood vessel does not match the measured motion of the blood vessel.

Computer program comprising computer program code means adapted to implement the method of any one of claims 1 to 11 when said computer program is run on a computer.

A processing unit, the processing unit comprising:
obtaining 2D ultrasound data of a blood vessel from a first measurement location, said 2D ultrasound data providing information about movement of said blood vessel;
obtaining 3D ultrasound data of the vessel from the first measurement location, the 3D ultrasound data providing information representing a 3D geometry of the vessel, the 2D ultrasound data and the 3D ultrasound data comprising: obtained from two separate ultrasound data acquisitions performed at the first measurement location;
determining motion of the vessel based on the motion of the vessel from the 2D ultrasound data;
Obtain non-invasive blood pressure readings,
providing the determined motion of the vessel, the 3D geometry of the vessel, and the noninvasive blood pressure measurement to a biomechanical model;
A processing unit configured to generate a stiffness measurement based on the biomechanical model.

a processing unit according to claim 13;
an ultrasound probe, said ultrasound probe configured to acquire said 2D ultrasound data, said probe further configured to acquire said 3D ultrasound data. , ultrasound system.

15. The system of Claim 14, wherein said system further comprises a blood pressure measurement device configured to obtain said non-invasive blood pressure measurement.