JPWO2020149715A5

JPWO2020149715A5 -

Info

Publication number: JPWO2020149715A5
Application number: JP2021541590A
Authority: JP
Publication date: 2023-01-30

Claims

A compound of Formula 1, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof:
[Chemical Formula 1]

In the above chemical formula 1,
(a)
A represents a carbon atom or a nitrogen atom,
R ¹ is linear or branched C1-6 alkoxy and R ² is hydrogen;
R ¹ and R ² are an 8- to 10-membered bicyclic ring containing one or more heteroatoms selected from the group consisting of N, O and S together with the benzene ring to which the carbon atom to which they are attached belongs. form,
L ¹ is sulfonyl or absent;
When L ¹ is sulfonyl, R ³ is straight or branched C1-6 alkyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, isoxazolidinyl and azaspirootanyl, wherein R3 is unsubstituted or morpholinyl, oxetanyl, ² -oxa-5-azabicyclo[2.2.1]heptanyl, further substituted with one or more non-hydrogen substituents selected from the group consisting of phenyl, amino, piperazinyl, piperidinyl, C3-9 cycloalkyl and linear or branched C1-6 alkyl, wherein said R ³ the non-hydrogen substituents are unsubstituted or further substituted with substituents selected from the group consisting of halogen, hydroxy, C3-9 cycloalkyl and linear or branched C1-6 alkyl;
When L ¹ is absent, R ³ is selected from phosphinic acid, azaphosphinane oxide, C1-6 alkylsulfonimidoyl and phosphine oxide, wherein R ³ is unsubstituted or oxetanyl, C3 -9 cycloalkyl, straight or branched chain C1-6 alkyl, acetyl, tetrahydropyranyl and benzyl, substituted with one or more non ^- hydrogen substituents selected from the group consisting of , unsubstituted or further substituted with C1-6 alkoxy or C1-6 alkyl,
L ² is —NH—, —O— or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is C3-9 cycloalkyl or amino, wherein R ⁴ is unsubstituted or further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen, or (b)
A represents a carbon atom or a nitrogen atom,
R ¹ and R ² form an 8- to 10-membered bicyclic ring containing at least one heteroatom selected from the group consisting of N, O and S together with the benzene ring to which the carbon atom to which they are attached belongs,
L ¹ is sulfonyl, carbonyl, or absent;
When L ¹ is sulfonyl or carbonyl, R ³ is straight or branched C1-6 alkyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, isoxa is selected from the group consisting of zolidinyl and azaspirootanyl, wherein R ³ is unsubstituted or morpholinyl, oxetanyl, 2-oxa-5-azabicyclo[2.2.1] further substituted with one or more non-hydrogen substituents selected from the group consisting of heptanyl, phenyl, amino, piperazinyl, piperidinyl, C3-9 cycloalkyl and linear or branched C1-6 alkyl, wherein said non-hydrogen substituents of R ³ are unsubstituted or further substituted with a substituent selected from the group consisting of halogen, hydroxy, C3-9 cycloalkyl and linear or branched C1-6 alkyl;
When L ¹ is absent, R ³ is selected from phosphinic acid, azaphosphinane oxide, C1-6 alkylsulfonimidoyl and phosphine oxide, wherein R ³ is unsubstituted, oxetanyl, C3- 9 substituted with one or more non-hydrogen substituents selected from the group consisting of cycloalkyl, straight or branched C1-6 alkyl, acetyl, tetrahydropyranyl and benzyl, wherein said non-hydrogen substituents of R ³ are unsubstituted or further substituted with C1-6 alkoxy or C1-6 alkyl;
L ² is —NH—, —O— or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is C3-9 cycloalkyl or amino, wherein R ⁴ is unsubstituted or further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen; a compound represented by, an isomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof;

A represents a carbon atom or a nitrogen atom,
R ¹ is linear or branched C1-6 alkoxy, R ² is hydrogen,
L ¹ is sulfonyl or absent;
When L ¹ is sulfonyl, R ³ is straight or branched C1-6 alkyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, isoxazolidinyl and azaspirootanyl, wherein R3 is unsubstituted or morpholinyl, oxetanyl, ² -oxa-5-azabicyclo[2.2.1]heptanyl, further substituted with one or more non-hydrogen substituents selected from the group consisting of phenyl, amino, piperazinyl, piperidinyl, C3-9 cycloalkyl and linear or branched C1-6 alkyl, wherein said R ³ the non-hydrogen substituents are unsubstituted or further substituted with substituents selected from the group consisting of halogen, hydroxy, C3-9 cycloalkyl and linear or branched C1-6 alkyl;
When L ¹ is absent, R ³ is selected from phosphinic acid, azaphosphinane oxide, C1-6 alkylsulfonimidoyl and phosphine oxide, wherein R ³ is unsubstituted or oxetanyl, C3 -9 cycloalkyl, straight or branched chain C1-6 alkyl, acetyl, tetrahydropyranyl and benzyl, substituted with one or more non ^- hydrogen substituents selected from the group consisting of , unsubstituted or further substituted with C1-6 alkoxy or C1-6 alkyl,
L ² is —NH—, —O— or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is unsubstituted or C3-9 cycloalkyl or amino, wherein R ⁴ is further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen;
The compound of formula 1 according to claim 1, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.

A represents a carbon atom,
R ¹ and R ² are an 8- to 10-membered bicyclic ring containing one or more heteroatoms selected from the group consisting of N, O and S together with the benzene ring to which the carbon atom to which they are attached belongs. form,
L ¹ is sulfonyl, carbonyl, or absent;
When L ¹ is sulfonyl or carbonyl, R ³ is straight or branched C1-6 alkyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, isoxa is selected from the group consisting of zolidinyl and azaspirootanyl, wherein R ³ is unsubstituted or morpholinyl, oxetanyl, 2-oxa-5-azabicyclo[2.2.1] further substituted with one or more non-hydrogen substituents selected from the group consisting of heptanyl, phenyl, amino, piperazinyl, piperidinyl, C3-9 cycloalkyl and linear or branched C1-6 alkyl, wherein said R the non-hydrogen substituents of ³ are unsubstituted or further substituted with substituents selected from the group consisting of halogen, hydroxy, C3-9 cycloalkyl and linear or branched C1-6 alkyl;
When L ¹ is absent, R ³ is selected from phosphinic acid, azaphosphinane oxide, C1-6 alkylsulfonimidoyl and phosphine oxide, wherein R ³ is unsubstituted or oxetanyl, C3 -9 cycloalkyl, straight or branched chain C1-6 alkyl, acetyl, tetrahydropyranyl and benzyl, substituted with one or more non ^- hydrogen substituents selected from the group consisting of , unsubstituted or further substituted with C1-6 alkoxy or C1-6 alkyl,
L ² is —NH—, —O— or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is unsubstituted or C3-9 cycloalkyl or amino, wherein R ⁴ is further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen;
The compound of formula 1 according to claim 1, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.

R ¹ and R ² form an 8- to 10-membered bicyclic ring containing at least one heteroatom selected from the group consisting of N, O and S together with the benzene ring to which the carbon atom to which they are attached belongs; the 8-10 membered bicyclic ring is dihydrobenzodioxin, dihydrobenzofuran, or benzodioxole;
The compound of formula 1 according to claim 3, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.

A represents a carbon atom,
R ¹ is linear or branched C1-6 alkoxy, R ² is hydrogen,
L ¹ is sulfonyl,
R ³ is from linear or branched C1-6 alkyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, isoxazolidinyl and azaspiroctanyl wherein R ³ is unsubstituted or morpholinyl, oxetanyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, phenyl, amino, piperazinyl, piperidinyl , C3-9 cycloalkyl and linear or branched C1-6 alkyl, wherein said non-hydrogen substituent of R ³ is substituted with unsubstituted or further substituted with a substituent selected from the group consisting of halogen, hydroxy, C3-9 cycloalkyl and linear or branched C1-6 alkyl;
L ² is -NH-, -O- or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is unsubstituted or C3-9 cycloalkyl or amino, wherein R ⁴ is further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen;
The compound of formula 1 according to claim 1, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.

A represents a carbon atom,
R ¹ is linear or branched C1-6 alkoxy, R ² is hydrogen,
L ¹ is absent,
R ³ is selected from phosphinic acid, azaphosphinane oxide, C1-6 alkylsulfonimidoyl and phosphine oxide, wherein R ³ is unsubstituted or oxetanyl, C3-9 cycloalkyl, linear or substituted with one or more non-hydrogen substituents selected from the group consisting of branched C1-6 alkyl, acetyl, tetrahydropyranyl and benzyl, wherein said non-hydrogen substituents of R ³ are unsubstituted or or further substituted with C1-6 alkoxy or C1-6 alkyl,
L ² is -NH-, -O- or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is unsubstituted or C3-9 cycloalkyl or amino, wherein R ⁴ is further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen;
The compound of formula 1 according to claim 1, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.

A represents a carbon atom,
R ¹ and R ² are an 8- to 10-membered bicyclic ring containing one or more heteroatoms selected from the group consisting of N, O and S together with the benzene ring to which the carbon atom to which they are attached belongs. form,
L ¹ is sulfonyl or carbonyl;
R ³ is from linear or branched C1-6 alkyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, isoxazolidinyl and azaspiroctanyl wherein R ³ is unsubstituted or morpholinyl, oxetanyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, phenyl, amino, piperazinyl, piperidinyl , C3-9 cycloalkyl and linear or branched C1-6 alkyl, wherein said non-hydrogen substituent of R ³ is substituted with unsubstituted or further substituted with a substituent selected from the group consisting of halogen, hydroxy, C3-9 cycloalkyl and linear or branched C1-6 alkyl;
L ² is —NH—, —O— or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is unsubstituted or C3-9 cycloalkyl or amino, wherein R ⁴ is further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen;
The compound of formula 1 according to claim 1, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.

A represents a carbon atom,
R ¹ and R ² are an 8- to 10-membered bicyclic ring containing one or more heteroatoms selected from the group consisting of N, O and S together with the benzene ring to which the carbon atom to which they are attached belongs. forming said 8-10 membered bicyclic ring is dihydrobenzodioxin, dihydrobenzofuran or benzodioxol;
L ¹ is sulfonyl or carbonyl;
R ³ is from linear or branched C1-6 alkyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, isoxazolidinyl and azaspiroctanyl wherein R ³ is unsubstituted or morpholinyl, oxetanyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, phenyl, amino, piperazinyl, piperidinyl , C3-9 cycloalkyl and linear or branched C1-6 alkyl, wherein said non-hydrogen substituent of R ³ is substituted with unsubstituted or further substituted with a substituent selected from the group consisting of halogen, hydroxy, C3-9 cycloalkyl and linear or branched C1-6 alkyl;
L ² is —NH—, —O— or absent;
When L ² is -NH- or -O-, R ⁴ is selected from the group consisting of C3-9 cycloalkyl, linear or branched C1-6 alkylamino and allyl, wherein R ⁴ is unsubstituted or further substituted with one or more non-hydrogen substituents selected from the group consisting of C1-6 alkylsulfonyl, C1-6 alkoxy and C1-6 alkyl;
when L ² is absent, R ⁴ is unsubstituted or C3-9 cycloalkyl or amino, wherein R ⁴ is further substituted with one or more C1-6 alkyl;
R ⁵ is hydrogen, cyano, C1-6 haloalkyl or halogen;
The compound of formula 1 according to claim 1, its isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.

The compound of Chemical Formula 1 according to claim 1, wherein the compound of Chemical Formula 1 is any one selected from the following compound group, its isomer, its solvate, its hydrate, or its Pharmaceutically acceptable salts:
<1> N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<2> (8-((4-(methylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin- 5-yl)(morpholino)methanone;
<3> (8-((4-(ethylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin- 5-yl)(morpholino)methanone 2,2,2-trifluoroacetate;
<4> morpholino (8-((4-(propylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin -5-yl)(morpholino)methanone 2,2,2-trifluoroacetate;
<5> (8-((4-(isopropylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin- 5-yl)(morpholino)methanone;
<6> (8-((4-(isobutylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin- 5-yl)(morpholino)methanone;
<7> (8-((4-(cyclopropylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin -5-yl)(morpholino)methanone;
<8> (8-((4-(cyclohexylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin- 5-yl)(morpholino)methanone;
<9> (8-((4-((2-(methylsulfonyl)ethyl)amino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(morpholino)methanone;
<10> N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -methyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<11> N ⁴ -ethyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine 2,2,2-trifluoro acetate;
<12> N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -propyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine 2,2,2-trifluoro acetate;
<13> N ⁴ -isopropyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<14> N ⁴ -isobutyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<15> N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<16> N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<17> N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<18> N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -methyl-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<19> N ⁴ -ethyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<20> N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -propyl-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<21> N ⁴ -isobutyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<22> N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6 - a diamine;
<23> N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<24> N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<25> N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -methyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<26> N ⁴ -ethyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<27> N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -propyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<28> N ⁴ -isopropyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<29> N ⁴ -isobutyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<30> N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<31> N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<32> (4-((4-(ethylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)(methyl)phosphinic acid;
<33> 4-(ethylamino)-6-((7-(morpholine-4-carbonyl)benzo[d][1,3]dioxin-4-yl)amino)-1H-pyrrolo[2,3-b ] pyridine-3-carbonitrile;
<34> 4-(ethylamino)-6-((7-(4-morpholinopiperidine-1-carbonyl)benzo[d][1,3]dioxol-4-yl)amino)-1H-pyrrolo[2, 3-b]pyridine-3-carbonitrile;
<35> 4-(ethylamino)-6-((8-(4-(oxetan-3-yl)piperazine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5 -yl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<36> 4-(cyclobutylamino)-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H- pyrrolo[2,3-b]pyridine-3-carbonitrile;
<37> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)benzo[d][1,3] dioxol-4-yl)(4-morpholinopiperidin-1-yl)methanone;
<38> (7-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)benzo[d][1,3] dioxol-4-yl)(morpholino)methanone;
<39> 4-(4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)- 1-(oxetan-3-yl)-1,4-azaphosphinane 4-oxide;
<40> N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -propyl-3-(trifluoromethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<41> 4-(3-methoxy-4-((4-((2-methoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl) amino)phenyl)-1-(oxetan-3-yl)-1,4-azaphosphinane 4-oxide;
<42> 1-(4-(4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxy phenyl)-4-oxide-1,4-azaphosphinan-1-yl)ethan-1-one;
<43> ((1S, 4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)(8-((4-(methylamino)-3-(trifluoromethyl)- 1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanone;
<44> ((1S, 4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)(8-((4-(ethylamino)-3-(trifluoromethyl)- 1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanone;
<45> 1-cyclopropyl-4-(3-methoxy-4-((4-(propylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl) amino)phenyl)-1,4-azaphosphinane 4-oxide;
<46> 4-(4-((4-(cyclobutylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl) -1-cyclopropyl-1,4-azaphosphinane 4-oxide;
<47> 4-(4-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)-1- (oxetan-3-yl)-1,4-azaphosphinane 4-oxide;
<48> 1-(4-(4-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl) -4-oxide-1,4-azaphosphinan-1-yl)ethan-1-one;
<49> (7-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)benzo[d][1,3]dioxole- 4-yl)(4-morpholinopiperidin-1-yl)methanone;
<50> (8-((4-(dimethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<51> (8-((4-(ethyl(methyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydro benzo[b][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<52> (7-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(morpholino)methanone;
<53> (7-((4-(cyclopropylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran- 4-yl)(morpholino)methanone;
<54> (7-((4-((2-methoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3 - dihydrobenzofuran-4-yl)(morpholino)methanone;
<55> (7-((4-((2-methoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3 -dihydrobenzofuran-4-yl)(4-morpholinopiperidin-1-yl)methanone;
<56> (8-((3-chloro-4-(methylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1, 4] dioxin-5-yl)(morpholino)methanone 2,2,2-trifluoroacetate;
<57> (8-((3-chloro-4-(ethylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1, 4] dioxin-5-yl)(morpholino)methanone;
<58> (8-((3-chloro-4-(propylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1, 4] dioxin-5-yl)(morpholino)methanone;
<59> (8-((3-chloro-4-(isopropylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1, 4] dioxin-5-yl)(morpholino)methanone;
<60> (8-((3-chloro-4-(cyclopropylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1 , 4] dioxin-5-yl)(morpholino)methanone;
<61> (8-((3-chloro-4-(cyclohexylamino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1, 4] dioxin-5-yl)(morpholino)methanone;
<62> (8-((3-chloro-4-((2-methoxyethyl)amino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[ b][1,4]dioxin-5-yl)(morpholino)methanone;
<63> (8-((3-chloro-4-((2-(methylsulfonyl)ethyl)amino)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3- dihydrobenzo[b][1,4]dioxin-5-yl)(morpholino)methanone;
<64> 3-chloro-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -methyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<65> 3-chloro-N ⁴ -ethyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<66> 3-chloro-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -propyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<67> 3-chloro-N ⁴ -isopropyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<68> 3-chloro-N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<69> 3-chloro-N ⁴ -cyclobutyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<70> 3-chloro-N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<71> 3-chloro-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<72> 3-chloro-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-1H-pyrrolo[2,3-b]pyridine-4 ,6-diamine;
<73> 3-chloro-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -methyl-1H-pyrrolo[2,3-b]pyridine- 4,6-diamine;
<74> 3-chloro-N ⁴ -ethyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine- 4,6-diamine;
<75> 3-chloro-N ⁴ -isopropyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine- 4,6-diamine;
<76> 3-chloro-N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine -4,6-diamine;
<77> 3-chloro-N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine- 4,6-diamine;
<78> 3-chloro-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -(2-methoxyethyl)-1H-pyrrolo[2,3 -b]pyridine-4,6-diamine;
<79> 3-chloro-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-1H-pyrrolo [ 2,3-b]pyridine-4,6-diamine;
<80> 3-chloro-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -methyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<81> 3-chloro-N ⁴ -ethyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<82> 3-chloro-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -propyl-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<83> 3-chloro-N ⁴ -isopropyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<84> 3-chloro-N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<85> 3-chloro-N ⁴ -cyclobutyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<86> 3-chloro-N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<87> 3-chloro-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<88> 3-chloro-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-1H-pyrrolo[2,3-b]pyridine-4 ,6-diamine;
<89> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(morpholino)methanone;
<90> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(4-morpholinopiperidin-1-yl)methanone;
<91> (7-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl ) (morpholino)methanone;
<92> (7-((4-(cyclopropylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran- 4-yl)(4-morpholinopiperidin-1-yl)methanone;
<93> (7-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl )(4-morpholinopiperidin-1-yl)methanone;
<94> 4-(4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)- 1-(tetrahydro-2H-pyran-4-yl)-1,4-azaphosphinane 4-oxide;
<95> 4-(3-methoxy-4-((4-((2-methoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl) amino)phenyl)-1-(tetrahydro-2H-pyran-4-yl)-1,4-azaphosphinane 4-oxide;
<96> N ⁴ -ethyl-N ⁶ -(8-((4-morpholinopiperidin-1-yl)sulfonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3 -(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<97> N ⁴ -(2-methoxyethyl)-N ⁶ -(8-((4-morpholinopiperidin-1-yl)sulfonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5 -yl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<98> N ⁴ -methyl-N ⁶ -(8-(morpholinosulfonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-(trifluoromethyl)-1H- pyrrolo[2,3-b]pyridine-4,6-diamine;
<99> N ⁴ -ethyl-N ⁶ -(8-(morpholinosulfonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-(trifluoromethyl)-1H- pyrrolo[2,3-b]pyridine-4,6-diamine;
<100> 4-cyclopropyl-N-(8-(morpholinosulfonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-(trifluoromethyl)-1H-pyrrolo [2,3-b]pyridin-6-amine;
<101> (8-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][ 1,4]dioxin-5-yl)(4-(oxetan-3-yl)piperazin-1-yl)methanone;
<102> 4-(4-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)-1- (tetrahydro-2H-pyran-4-yl)-1,4-azaphosphinane 4-oxide;
<103> N ⁶ -(2-methoxy-4-(s-methylsulfonylimidoyl)phenyl)-N ⁴ -methyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4 ,6-diamine;
<104> N ⁴ -ethyl-N ⁶ -(4-((4-morpholinopiperidin-1-yl)sulfonyl)-2,3-dihydrobenzofuran-7-yl)-3-(trifluoromethyl)-1H- pyrrolo[2,3-b]pyridine-4,6-diamine;
<105> (4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl)(7-((4-(ethylamino) -3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<106> 4-(methylamino)-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H-pyrrolo [2,3-b]pyridine-3-carbonitrile;
<107> 4-(ethylamino)-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H-pyrrolo [2,3-b]pyridine-3-carbonitrile;
<108> 6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-4-(propylamino)-1H-pyrrolo [2,3-b]pyridine-3-carbonitrile;
<109> 4-((2-methoxyethyl)amino)-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino )-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<110> 4-((2-(methylsulfonyl)ethyl)amino)-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5- yl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<111> 4-(cyclopropylamino)-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H- pyrrolo[2,3-b]pyridine-3-carbonitrile;
<112> 4-(cyclopentylamino)-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H-pyrrolo [2,3-b]pyridine-3-carbonitrile;
<113> 4-(ethylamino)-6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)- 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<114> 6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-4-(propylamino)- 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<115> 4-(methylamino)-6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)- 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<116> 4-(cyclopropylamino)-6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino) -1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<117> 4-(cyclobutylamino)-6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino) -1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<118> 4-((2-methoxyethyl)amino)-6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5- yl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<119> 6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-4-((2-(methylsulfonyl)ethyl)amino)-1H-pyrrolo[2,3-b]pyridine-3 - carbonitrile;
<120>4-(cyclobutylamino)-6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<121>4-(cyclopentylamino)-6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<122>4-(cyclopropylamino)-6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<123>6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-4-(methylamino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<124>4-(ethylamino)-6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<125>6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-4-(propylamino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<126>6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-4-((2-methoxyethyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<127>4-(cyclopropylamino)-6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<128>4-(cyclobutylamino)-6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<129>6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-4-((2-methoxyethyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<130> 6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-4-((2-(methylsulfonyl)ethyl)amino)-1H-pyrrolo[2,3-b]pyridine-3 - carbonitrile;
<131>6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-4-(methylamino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<132>4-(ethylamino)-6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<133>6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-4-(propylamino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<134> 4-(cyclopropylamino)-6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine -3-carbonitrile;
<135> 4-(cyclobutylamino)-6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine -3-carbonitrile;
<136> 4-(cyclopentylamino)-6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine- 3-carbonitrile;
<137> 6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-4-(methylamino)-1H-pyrrolo[2,3-b]pyridine- 3-carbonitrile;
<138> 4-(ethylamino)-6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine- 3-carbonitrile;
<139> 6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-4-(propylamino)-1H-pyrrolo[2,3-b]pyridine- 3-carbonitrile;
<140> 6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-4-((2-methoxyethyl)amino)-1H-pyrrolo[2,3 -b]pyridine-3-carbonitrile;
<141> 6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-4-((2-(methylsulfonyl)ethyl)amino)-1H-pyrrolo [ 2,3-b]pyridine-3-carbonitrile;
<142> 6-((2-methoxy-4-(1-(oxetan-3-yl)-4-oxide-1,4-azaphosphinan-4-yl)phenyl)amino)-4-(methylamino)- 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<143> 4-(ethylamino)-6-((2-methoxy-4-(1-(oxetan-3-yl)-4-oxide-1,4-azaphosphinan-4-yl)phenyl)amino)- 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<144> 6-((2-methoxy-4-(1-(oxetan-3-yl)-4-oxide-1,4-azaphosphinan-4-yl)phenyl)amino)-4-((2-methoxy ethyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<145> 6-((4-(1-acetyl-4-oxide-1,4-azaphosphinan-4-yl)-2-methoxyphenyl)amino)-4-(ethylamino)-1H-pyrrolo[2, 3-b]pyridine-3-carbonitrile;
<146> 6-((4-(1-cyclopropyl-4-oxide-1,4-azaphosphinan-4-yl)-2-methoxyphenyl)amino)-4-(methylamino)-1H-pyrrolo[2 ,3-b]pyridine-3-carbonitrile;
<147> 6-((4-(1-cyclopropyl-4-oxide-1,4-azaphosphinan-4-yl)-2-methoxyphenyl)amino)-4-(ethylamino)-1H-pyrrolo[2 ,3-b]pyridine-3-carbonitrile;
<148> 6-((4-(1-cyclopropyl-4-oxide-1,4-azaphosphinan-4-yl)-2-methoxyphenyl)amino)-4-((2-methoxyethyl)amino)- 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<149> 4-(cyclohexylamino)-6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)- 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<150> N ⁴ -(cyclohexylamino)-N ⁶ -((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H - pyrrolo[2,3-b]pyridine-3-carbonitrile;
<151> N ⁴ -(cyclohexylamino)-N ⁶ -((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b] pyridine-3-carbonitrile;
<152> (8-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(morpholino)methanone;
<153> (8-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(morpholino)methanone;
<154> (8-((4-(cyclohexylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(morpholino)methanone;
<155> (8-((4-(cyclopropylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[ b][1,4]dioxin-5-yl)(morpholino)methanone 2,2,2-trifluoroacetate;
<156> (8-((4-(isobutylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(morpholino)methanone;
<157> (8-((4-((2-(methylsulfonyl)ethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)- 2,3-dihydrobenzo[b][1,4]dioxin-5-yl)(morpholino)methanone;
<158> (8-((4-((2-methoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3 - dihydrobenzo[b][1,4]dioxin-5-yl)(morpholino)methanone;
<159> (R)-(8-((4-((1-methoxypropan-2-yl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-6- yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)(morpholino)methanone;
<160> (8-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<161> (8-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<162> (4-morpholinopiperidin-1-yl)(8-((4-(propylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino )-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanone;
<163> (8-((4-(cyclopropylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[ b][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<164> (8-((4-((2-methoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3 - dihydrobenzo[b][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<165> (8-((4-((2-(methylsulfonyl)ethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)- 2,3-dihydrobenzo[b][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<166> (8-((4-((2-ethoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3 - dihydrobenzo[b][1,4]dioxin-5-yl)(morpholino)methanone;
<167> (8-((4-((2-ethoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3 - dihydrobenzo[b][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<168> (8-((4-(isopropylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(morpholino)methanone;
<169> (8-((4-(butylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(morpholino)methanone;
<170> (8-((4-(butylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<171> (8-((4-((2-(dimethylamino)ethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)- 2,3-dihydrobenzo[b][1,4]dioxin-5-yl)(morpholino)methanone;
<172> (8-((4-((2-(dimethylamino)ethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)- 2,3-dihydrobenzo[b][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<173> (8-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b ][1,4]dioxin-5-yl)(4-(oxetan-3-yl)piperazin-1-yl)methanone;
<174> morpholino (8-((4-(propylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo [ b][1,4]dioxin-5-yl)methanone;
<175> (8-((4-(cyclobutylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[ b][1,4]dioxin-5-yl)(morpholino)methanone 2,2,2-trifluoroacetate;
<176> (8-((4-(cyclobutylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[ b][1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<177> N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -methyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<178> N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -methyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<179> N ⁴ -ethyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<180> N ⁴ -ethyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<181> N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<182> N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<183> N ⁴ -cyclohexyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<184> N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -methyl-3-(trifluoromethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<185> N ⁴ -ethyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<186> N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<187> N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6- diamine;
<188> N ⁴ -cyclopropyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3 -b]pyridine-4,6-diamine 2,2,2-trifluoroacetate;
<189> N ⁴ -isobutyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<190> N ⁴ -isobutyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<191> N ⁴ -isobutyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<192> N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b ] pyridine-4,6-diamine;
<193> N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b ] pyridine-4,6-diamine;
<194> N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -(2-(methylsulfonyl)ethyl)-3-(trifluoromethyl)- 1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<195> N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -(2-methoxyethyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine- 4,6-diamine;
<196> (R)—N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -(1-methoxypropan-2-yl)-3-( trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<197> N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -(2-methoxyethyl)-3-(trifluoromethyl)-1H-pyrrolo [2,3-b]pyridine-4,6-diamine;
<198> N ⁴ -isopropyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<199> N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-N ⁴ -propyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<200> N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -propyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<201> N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-N ⁴ -(2-methoxyethyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine- 4,6-diamine;
<202> N ⁴ -cyclobutyl-N ⁶ -(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3- b] pyridine-4,6-diamine;
<203> N ⁴ -cyclobutyl-N ⁶ -(2-methoxy-4-(morpholinosulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<204> N ⁴ -cyclobutyl-N ⁶ -(2-methoxy-4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine ;
<205> 1-cyclopropyl-4-(3-methoxy-4-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl) amino)phenyl)-1,4-azaphosphinane 4-oxide;
<206> 1-cyclopropyl-4-(4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3 -methoxyphenyl)-1,4-azaphosphinane 4-oxide;
<207> 1-cyclopropyl-4-(3-methoxy-4-((4-((2-methoxyethyl)amino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine) -6-yl)amino)phenyl)-1,4-azaphosphinane 4-oxide;
<208> (4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)(methyl) (4-morpholinopiperidin-1-yl)phosphine oxide;
<209> (4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)dimethylphosphine oxide ;
<210> 1-ethyl-4-(4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3- methoxyphenyl)-1,4-azaphosphinane 4-oxide;
<211> 1-cyclopropyl-4-(4-((4-(cyclopropylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)- 3-methoxyphenyl)-1,4-azaphosphinane 4-oxide;
<212> 4-(3-methoxy-4-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)phenyl)- 1-(oxetan-3-yl)-1,4-azaphosphinane 4-oxide;
<213> (R)-(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3- dihydrobenzofuran-4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<214> (R)-(7-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3- dihydrobenzofuran-4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<215> (S)-(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3- dihydrobenzofuran-4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<216> 4-(3-methoxy-4-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)phenyl)- 1-(tetrahydro-2H-pyran-4-yl)-1,4-azaphosphinane 4-oxide;
<217> (S)-(7-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3- dihydrobenzofuran-4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<218> 1-cyclopropyl-4-(4-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxy phenyl)-1,4-azaphosphinane 4-oxide;
<219> (4-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)dimethylphosphine oxide;
<220> (8-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][ 1,4]dioxin-5-yl)(morpholino)methanone;
<221> (8-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][ 1,4]dioxin-5-yl)(4-morpholinopiperidin-1-yl)methanone;
<222>4-cyclopropyl-N-(2-methoxy-4-(morpholinosulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-amine;
<223> 4-cyclopropyl-N-(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b ] pyridin-6-amine;
<224>4-cyclopropyl-N-(2-methoxy-4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-amine;
<225> 4-cyclopropyl-6-((8-(morpholine-4-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H-pyrrolo[2 ,3-b]pyridine-3-carbonitrile;
<226> 4-cyclopropyl-6-((8-(4-morpholinopiperidine-1-carbonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-1H- pyrrolo[2,3-b]pyridine-3-carbonitrile;
<227>4-cyclopropyl-6-((2-methoxy-4-(morpholinosulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<228> 4-cyclopropyl-6-((2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3- Carbonitrile;
<229>4-cyclopropyl-6-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<230>4-cyclopropyl-6-((4-(dimethylphosphoryl)-2-methoxyphenyl)amino)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;
<231> (8-((4-ethoxy-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzo[b][1 , 4] dioxin-5-yl)(morpholino)methanone;
<232> 4-ethoxy-N-(2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b] pyridin-6-amine;
<233> N ⁴ -methyl-N ⁶ -(8-((4-morpholinopiperidin-1-yl)sulfonyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3 -(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<234> (7-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(4-morpholinopiperidin-1-yl)methanone;
<235> (7-((4-(methylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)benzo[d][1,3] dioxol-4-yl)(4-morpholinopiperidin-1-yl)methanone;
<236> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)benzo[d][1,3] dioxol-4-yl)(morpholino)methanone;
<237> (S)-(7-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran -4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<238> (R)-(7-((4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran -4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<239> N-(4-((4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl)sulfonyl)-2- methoxyphenyl)-4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-amine;
<240> N-(4-((4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl)sulfonyl)-2- methoxyphenyl)-4-cyclopropyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-amine;
<241> (4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl)(7-((4-(methylamino) -3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<242> N ⁶ -(4-((4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl)sulfonyl)-2 -methoxyphenyl)-N ⁴ -methyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<243> N ⁶ -(4-((4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl)sulfonyl)-2 -methoxyphenyl)-N ⁴ -methyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine;
<244> (4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl)(7-((4-(ethylamino) -3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<245> (R)-(3-(3,5-difluorophenyl)isoxazolidin-2-yl)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2 ,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<246> (S)-(3-(3,5-difluorophenyl)isoxazolidin-2-yl)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2 ,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<247> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(4-(4-methylpiperazin-1-yl)piperidin-1-yl)methanone;
<248> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(4-(oxetan-3-yl)piperazin-1-yl)methanone;
<249> (4-(dimethylamino)piperidin-1-yl)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-6- yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<250> (4-cyclopropylpiperazin-1-yl) (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl) amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<251> (4-cyclopentylpiperazin-1-yl) (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino )-2,3-dihydrobenzofuran-4-yl)methanone;
<252> (4-allylpiperazin-1-yl)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino )-2,3-dihydrobenzofuran-4-yl)methanone;
<253> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone;
<254> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(4-isopropylpiperazin-1-yl)methanone;
<255> (7-((4-(allylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4- yl)(4-morpholinopiperidin-1-yl)methanone;
<256> (7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4 -yl)(6-azaspiro[2.5]octan-6-yl)methanone;
<257> (4-(cyclopropylmethyl)piperazin-1-yl)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-6 -yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<258> ((2S,6R)-2,6-dimethylmorpholino)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-6 -yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<259> (S)-(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3- dihydrobenzofuran-4-yl)(2-methylmorpholino)methanone;
<260> (R)-(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3- dihydrobenzofuran-4-yl)(2-methylmorpholino)methanone;
<261> (R)-(7-((4-(allylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydro benzofuran-4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<262> (S)-(7-((4-(allylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-2,3-dihydro benzofuran-4-yl)(3-morpholinopyrrolidin-1-yl)methanone;
<263> (4-((2S,6R)-2,6-dimethylmorpholino)piperidin-1-yl)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo [ 2,3-b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<264> (4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl)(7-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3 -b]pyridin-6-yl)amino)-2,3-dihydrobenzofuran-4-yl)methanone;
<265> N ⁶ -(5-fluoro-2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-N ⁴ -methyl-3-(trifluoromethyl)-1H-pyrrolo [ 2,3-b]pyridine-4,6-diamine;
<266> N ⁴ -ethyl-N ⁶ -(5-fluoro-2-methoxy-4-((4-morpholinopiperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrrolo [ 2,3-b]pyridine-4,6-diamine;
<267> 1-(2,4-dimethoxybenzyl)-4-(6-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-6- yl)amino)pyridin-3-yl)-1,4-azaphosphinane 4-oxide.

ALK, ALK(C1156Y), ALK(L1196M), CLK1 comprising the compound of Formula 1 according to claim 1, its isomer, its solvate, its hydrate or its pharmaceutically acceptable salt as an active ingredient , CLK2, CLK3, CLK4, DYRK1A, DYRK1B, DYRK2, GAK, LRRK2, LRRK2 (G2019S), MYLK, and TTK.

11. The pharmaceutical composition according to claim 10, wherein said protein kinase-related disease is one or more selected from the group consisting of cancer, degenerative brain disease, and inflammatory disease.

The degenerative brain disease is selected from the group consisting of Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease, dementia, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, paralysis, stroke, and mild cognitive impairment. 12. The pharmaceutical composition according to claim 11, which is one or more of

Said inflammatory diseases include dermatitis, allergy, gastric ulcer, duodenal ulcer, hepatitis, esophagitis, gastritis, enteritis, pancreatitis, colitis, nephritis, systemic edema, local edema, arthritis, keratitis, bronchitis, pleurisy, peritonitis. , spondylitis, inflammatory pain, urethritis, cystitis, periodontitis, and gingivitis.

The cancer is triple-negative breast cancer, brain cancer, brain tumor, positive astrocytoma, malignant astrocytoma, pituitary adenoma, brain meningioma, brain lymphoma, oligodendroglioma, craniopharyngioma, ependymoma, brain stem tumor , head and neck tumor, laryngeal cancer, oropharyngeal cancer, nasal cavity/sinus cancer, nasopharyngeal cancer, salivary gland cancer, hypopharyngeal cancer, thyroid cancer, oral cancer, breast tumor, small cell lung cancer, non-small cell lung cancer, thymic cancer , mediastinal tumor, esophageal cancer, breast cancer, male breast cancer, abdominal tumor, gastric cancer, liver cancer, gallbladder cancer, biliary tract cancer, pancreatic cancer, small bowel cancer, colon cancer, rectal cancer, anal cancer, bladder cancer, kidney cancer, male genital tumor , penile cancer, prostate cancer, female genital cancer, cervical cancer, endometrial cancer, ovarian cancer, uterine sarcoma, vaginal cancer, female genital cancer, female urethral cancer, and skin cancer. 12. The pharmaceutical composition of claim 11, which is

The compound is selected from the group consisting of ALK, ALK(C1156Y), ALK(L1196M), CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B, DYRK2, GAK, LRRK2, LRRK2(G2019S), MYLK, and TTK1 11. A pharmaceutical composition according to claim 10, which exhibits inhibitory activity against more than one species of protein kinase.