JPWO2020145661A5 - - Google Patents

Claims (20)

A pharmaceutical composition for the prevention or treatment of one or more diseases selected from the group consisting of cancer, inflammatory diseases, and neurological diseases, which comprises vesicles derived from Deinococcus bacteria as an active ingredient. The cancer is one or more selected from the group consisting of gastric cancer, lung cancer, pancreatic cancer, bile duct cancer, breast cancer, bladder cancer, liver cancer, ovarian cancer, kidney cancer, prostate cancer, colon cancer, head and neck cancer, and lymphoma. The pharmaceutical composition according to claim 1 , wherein the pharmaceutical composition is characterized by the above. The inflammatory diseases include gingitis, periodontitis, gastric inflammation, inflammatory enteritis, colitis, atopy dermatitis, acne, hair loss, psoriasis, rheumatism, nasal polyps, asthma, chronic obstructive pulmonary disease (COPD), and degenerative arthritis. The pharmaceutical composition according to claim 1 , wherein the composition is one or more selected from the group consisting of rheumatoid arthritis and rheumatoid arthritis. The inflammatory disease is characterized by being a disease mediated by interleukin-6 (Interleukin-6, IL-6) or tumor necrosis factor alpha (Tumor necrosis factor-α, TNF-α). The pharmaceutical composition according to. The neurological disorder is characterized by being one or more selected from the group consisting of depression, obsessive-compulsive disorder, schizophrenia, dementia, Alzheimer's disease, epilepsy, autism, and Parkinson's disease. Item 2. The pharmaceutical composition according to Item 1 . The pharmaceutical composition according to claim 1 , wherein the vesicles have an average diameter of 10 to 200 nm. The pharmaceutical composition according to claim 1 , wherein the vesicles are naturally or artificially secreted from a bacterium belonging to the genus Deinococcus. The pharmaceutical composition according to claim 1 , wherein the vesicles derived from the genus Deinococcus are secreted from Deinococcus radiodurans. A food composition for preventing or ameliorating one or more diseases selected from the group consisting of cancer, inflammatory diseases, and cranial nerve diseases, which comprises vesicles derived from Deinococcus bacteria as an active ingredient. The food composition according to claim 9 , wherein the vesicles have an average diameter of 10 to 200 nm. The food composition according to claim 9 , wherein the vesicles are naturally or artificially secreted from a Deinococcus bacterium. The food composition according to claim 9 , wherein the vesicles derived from the genus Deinococcus are secreted from Deinococcus radiodurans. An inhalant composition for the prevention or treatment of one or more diseases selected from the group consisting of cancer, inflammatory diseases, and cranial nerve diseases, which comprises vesicles derived from Deinococcus bacteria as an active ingredient. A cosmetic composition for preventing or ameliorating inflammatory skin diseases, which comprises vesicles derived from Deinococcus bacteria as an active ingredient. The cosmetic composition according to claim 14 , wherein the inflammatory skin disease is one or more selected from the group consisting of atopic dermatitis, acne, hair loss, and psoriasis. Use of vesicles derived from Deinococcus bacteria for the production of agents used in the treatment of one or more diseases selected from the group consisting of cancer, inflammatory disease, and cranial nerve disease. Informational methods for diagnosing cancer, inflammatory disease, or dementia, including the following steps:
(A) Step of extracting DNA from vesicles isolated from normal human and subject samples;
(B) A step of obtaining each PCR product after performing PCR (Polymerase Chain Reaction) using a primer pair prepared based on the gene sequence present in 16S rDNA for the extracted DNA;
(C) When the content of vesicles derived from Deinococcus bacteria is lower than that of normal humans through quantitative analysis of the PCR product, it is classified as cancer, inflammatory disease, or dementia. The information providing method according to claim 17, wherein the sample in the step (a) is blood. The cancer is one or more selected from the group consisting of gastric cancer, lung cancer, pancreatic cancer, bile duct cancer, breast cancer, bladder cancer, liver cancer, ovarian cancer, kidney cancer, prostate cancer, colon cancer, head and neck cancer, and lymphoma. The information providing method according to claim 17, wherein the information is provided. The inflammatory diseases include gingitis, periodontitis, gastric inflammation, inflammatory bowel inflammation, colitis, atopy dermatitis, acne, hair loss, psoriasis, rheumatism, nasal polyps, asthma, chronic obstructive pulmonary disease (COPD), and degenerative arthritis. , And the method for providing information according to claim 17, wherein the information is one or more selected from the group consisting of rheumatoid arthritis.