JPWO2020109957A5 - - Google Patents

Claims (4)

Formula I:

(wherein RH is independently

, caprylic acid, 1-hydroxy-2-naphthoic acid, 2,2-dichloroacetic acid, 2-hydroxyethanesulfonic acid, 2-oxoglutaric acid, 4-acetamidobenzoic acid, 4-aminosalicylic acid, acetic acid, adipic acid, ascorbic acid , aspartic acid, benzenesulfonic acid, benzoic acid, camphoric acid, camphor-10-sulfonic acid, capric acid (decanoic acid), caproic acid (hexanoic acid), carbonic acid, cinnamic acid, citric acid, cyclamic acid, dodecyl sulfate, ethane -1,2-disulfonic acid, ethanesulfonic acid, formic acid, fumaric acid, galactaric acid, gentisic acid, glucoheptonic acid, gluconic acid, glucuronic acid, glutamic acid, glutaric acid, glycerophosphoric acid, glycolic acid, hippuric acid, hydrobromic acid , isobutyric acid, lactic acid, lactobionic acid, lauric acid, maleic acid, malic acid, malonic acid, mandelic acid, methanesulfonic acid, naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, nicotinic acid, nitric acid, olein Acid, oxalic acid, palmitic acid, pamoic acid, phosphoric acid, propionic acid, pyroglutamic acid, salicylic acid, sebacic acid, stearic acid, succinic acid, sulfuric acid, tartaric acid, thiocyanic acid, toluenesulfonic acid, undecylenic acid, omega-3 fatty acids, α-linol acid, alpha-linolenic acid, omega-6 fatty acid, n-acetylcysteine (nac), furoate, methyl furoate, ethyl furoate, aminocaproic acid, caprylic acid, alpha-lipoic acid, R-lipoic acid, myristic acid, myristoleic acid, palmitolein acid, phospholipids, phosphatidylcholine, elaidic acid, linoleic acid, linolenic acid, menthol, retinoic acid, vitamin A, retinol, linoleic elaidic acid, arachidonic acid, retinal, isotretinoin, curcumin, tretinoin, α-carotene, β-carotene, d2 Ergosterol, ergocalciferol, 7-dehydrocholesterol, cholecalciferol, 25-hydroxycholecalciferol, calcitriol (1,25-dihydroxycholecalciferol), calcitronic acid, d4 dihydroergocalciferol, alphacalcidol, dihydro tachysterol, calcipotriol, tacalcitol, paricalcitol, tocopherol, naphthoquinone, phylloquinone (k1), menaquinone (k2), menadione (k3), menadiol (k4), thiamine, acefluthiamine, allithiamine, benfotiamine, flu sultiamine, octoti Amine, prosultiamine, sulbutiamine, riboflavin, niacin, nicotinamide, pantothenic acid, dexpanthenol, pantethine, pyridoxine, pyridoxal phosphate, pyridoxamine, pyritinol, biotin, folic acid, dihydrofolic acid, folinic acid, levomefolic acid, adenosylcobalamin , cyanocobalamin, hydroxocobalamin, methylcobalamin, choline, dehydroascorbic acid, or 1-docosanol), and pharmaceutically acceptable hydrates, solvates, enantiomers, and stereoisomers thereof. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. topical eye drops, topical pastes, ophthalmic solutions, drug delivery devices, oral administration, buccal administration, rectal administration, topical administration, transdermal administration, transmucosal administration, lozenges, sprays, intravenous administration, oral solutions, nasal 3. A medicament according to claim 2 , formulated for internal spray, cream, skin ointment, gel, lotion, suspension, mouth spray, buccal layer tablet, parenteral administration, syrup or injection. Composition. structure:

compound.