JPWO2020102234A5 - - Google Patents

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JPWO2020102234A5
JPWO2020102234A5 JP2021523237A JP2021523237A JPWO2020102234A5 JP WO2020102234 A5 JPWO2020102234 A5 JP WO2020102234A5 JP 2021523237 A JP2021523237 A JP 2021523237A JP 2021523237 A JP2021523237 A JP 2021523237A JP WO2020102234 A5 JPWO2020102234 A5 JP WO2020102234A5
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component
delivery member
hydrogel
connector
container
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Priority claimed from PCT/US2019/060985 external-priority patent/WO2020102234A1/en
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Claims (13)

容器アセンブリの少なくとも一部分を受け取るように構成される、覆いであって、前記容器アセンブリが、第１の成分を包含する第１の容器と、第２の成分を包含する第２の容器とを含み、前記第１の容器及び前記第２の容器が、コネクタに連結するように構成され、前記容器アセンブリが、第１のプランジャ及び第２のプランジャを含む、覆いと、
送達部材であって、前記送達部材によって画定される混合体積と流体連通して、前記コネクタの第１の出口及び前記コネクタの第２の出口を設けるように、前記コネクタに連結されるよう構成される、送達部材と、
前記容器アセンブリに動作可能に連結するように構成される、駆動アセンブリであって、
前記第１の成分の第１の部分を、前記容器アセンブリから前記コネクタの第１の出口に運び、前記第２の成分の第１の部分を、前記容器アセンブリから前記コネクタの第２の出口に運ぶことによって、前記コネクタをプライミングし、
前記第１の成分の第２の部分が、前記第２の成分の第２の部分と架橋して、前記送達部材内にハイドロゲルを形成するように、前記第１の成分の前記第２の部分及び前記第２の成分の前記第２の部分を、前記混合体積の中へ運び、
前記送達部材から、前記送達部材の出口部分を介して、前記ハイドロゲルを運ぶ、ように構成された駆動アセンブリと、を備える、装置。 A cover configured to receive at least a portion of a container assembly, said container assembly including a first container containing a first component and a second container containing a second component. a cover wherein the first container and the second container are configured to couple to a connector, the container assembly including a first plunger and a second plunger;
a delivery member configured to be coupled to the connector to provide a first outlet of the connector and a second outlet of the connector in fluid communication with a mixing volume defined by the delivery member; a delivery member;
a drive assembly configured to operatively couple to the container assembly, comprising:
conveying a first portion of said first component from said container assembly to a first outlet of said connector and conveying a first portion of said second component from said container assembly to a second outlet of said connector; priming the connector by carrying;
said second portion of said first component such that said second portion of said first component crosslinks with said second portion of said second component to form a hydrogel within said delivery member; conveying a portion and said second portion of said second component into said mixing volume;
and a drive assembly configured to carry the hydrogel from the delivery member through an outlet portion of the delivery member . 前記容器アセンブリが、前記第１の成分を含む第１の容器と、前記第２の成分を含み、前記第１の容器から分離している第２の容器とを含み、wherein the container assembly comprises a first container containing the first component and a second container separate from the first container containing the second component;
前記コネクタが、前記第１の容器に接続される第１の入口と、前記第２の容器に接続される第２の入口とを含む、請求項１に記載の装置。2. The device of claim 1, wherein the connector includes a first inlet connected to the first container and a second inlet connected to the second container. 前記送達部材が第１の送達部材であり、前記ハイドロゲルが第１のハイドロゲルであり、said delivery member is a first delivery member and said hydrogel is a first hydrogel;
前記駆動アセンブリは、The drive assembly includes:
前記第１の送達部材が前記コネクタから取り外された後に、前記第１の成分の第３の部分を、前記コネクタの前記第１の出口に運び、前記第２の成分の第３の部分を、前記コネクタの前記第２の出口に運ぶことによって、前記コネクタをプライミングし、conveying a third portion of the first component to the first outlet of the connector after the first delivery member is removed from the connector; priming the connector by bringing it to the second outlet of the connector;
第２の送達部材が前記コネクタに連結された後に、前記第１の成分の第４の部分、及び前記第２の成分の第４の部分を、第２の混合体積に運び、前記第１の成分の前記第４の部分が、前記第２の成分の前記第４の部分と架橋して、前記第２の混合体積の中に第２のハイドロゲルを形成させる、ように構成された、請求項１又は２に記載の装置。After a second delivery member is coupled to the connector, a fourth portion of the first component and a fourth portion of the second component are conveyed to a second mixing volume and wherein the fourth portion of the component is configured to crosslink with the fourth portion of the second component to form a second hydrogel within the second mixed volume. Item 3. The device according to Item 1 or 2. 前記駆動アセンブリは、The drive assembly includes:
前記第１の成分の前記第２の部分及び前記第２の成分の前記第２の部分を、前記ハイドロゲルのゲル化時間以上の滞留時間にわたって前記送達部材の内部に保持される、ように構成された、請求項１又は２に記載の装置。configured such that the second portion of the first component and the second portion of the second component are retained within the delivery member for a residence time greater than or equal to the gelation time of the hydrogel. 3. Apparatus according to claim 1 or 2, comprising: 運ばれた前記ハイドロゲルが、対象領域の少なくとも一部を閉塞するよう調合される、請求項１又は２に記載の装置。3. The device of claim 1 or 2, wherein the delivered hydrogel is formulated to occlude at least a portion of a target area. 前記駆動アセンブリは、前記ハイドロゲルを前記送達部材から３０秒未満で運ぶよう構成された、請求項１又は２に記載の装置。3. The device of claim 1 or 2, wherein the drive assembly is configured to carry the hydrogel from the delivery member in less than 30 seconds. 前記駆動アセンブリは、約５０マイクロリットルから約２００マイクロリットルの前記ハイドロゲルを、前記送達部材から約５秒から約２０秒の間で運ぶよう構成された、請求項１又は２に記載の装置。3. The device of claim 1 or 2, wherein the drive assembly is configured to convey from about 50 microliters to about 200 microliters of the hydrogel from the delivery member in between about 5 seconds and about 20 seconds. 前記駆動アセンブリは電気機械駆動部、をさらに含み、the drive assembly further includes an electromechanical drive;
電子制御システムであって、前記送達部材から運ばれてきた前記ハイドロゲルの流出力を、流出力の閾値未満に維持するように、前記電気機械駆動部を制御する駆動信号を生成する、電気制御システム、をさらに含む、請求項１又は２に記載の装置。an electronic control system for generating a drive signal to control the electromechanical drive to maintain the outflow force of the hydrogel delivered from the delivery member below a threshold outflow force; 3. The apparatus of claim 1 or 2, further comprising: a system. 前記駆動アセンブリは電気機械駆動部、をさらに含み、the drive assembly further includes an electromechanical drive;
電子制御システムであって、An electronic control system,
前記ハイドロゲルが送達体積を生成するように運ばれる時間内は、前記送達部材内の前記ハイドロゲルの速度を、所定の速度範囲内に維持するように、前記電気機械駆動部を制御する駆動信号を生成する、電子制御システム、をさらに含む、請求項１又は２に記載の装置。a drive signal controlling the electromechanical drive to maintain the velocity of the hydrogel within the delivery member within a predetermined velocity range for the time the hydrogel is conveyed to create a delivery volume; 3. The apparatus of claim 1 or 2, further comprising an electronic control system for generating the . 前記送達部材の前記コネクタへの連結は、空気のボーラスを前記混合体積内に存在させるように行われ、coupling the delivery member to the connector so as to cause a bolus of air to reside within the mixing volume;
前記第１の成分の前記第２の部分、及び前記第２の成分の前記第２の部分を、前記混合体積の中へ運ぶことによって、前記ハイドロゲルが対象領域に運ばれる前に、前記空気のボーラスを、前記対象領域の中へ送達させる、請求項１又は２に記載の装置。the air before the hydrogel is conveyed to a target area by conveying the second portion of the first component and the second portion of the second component into the mixing volume; 3. The device of claim 1 or 2, wherein a bolus of is delivered into the target area. 前記第１の成分は、双直交リンキング化学（ｂｉｏｒｔｈｏｇｏｎａｌ ｌｉｎｋｉｎｇ ｃｈｅｍｉｓｔｒｙ）が可能な第１の水溶性ポリマーであり、the first component is a first water-soluble polymer capable of biorthogonal linking chemistry;
前記第２の成分は、前記第１の成分が前記第２の成分と架橋されて、前記ハイドロゲルを形成できるような、双直交リンキング化学が可能な第２の水溶性ポリマーである、請求項１又は２に記載の装置。4. The second component is a second water soluble polymer capable of biorthogonal linking chemistry such that the first component can be crosslinked with the second component to form the hydrogel. 3. The device according to 1 or 2. 前記ハイドロゲルは、前記送達部材における前記第１の成分と前記第２の成分との化学反応が完了した高次構造であり、the hydrogel is a higher-order structure in which the chemical reaction between the first component and the second component in the delivery member is complete;
前記ハイドロゲルは、前記高次構造として前記送達部材の流出開口部から運び出されるように構成された、請求項１又は２に記載の装置。3. The device of claim 1 or 2, wherein the hydrogel is configured to be carried out of the outflow opening of the delivery member as the conformation. 前記駆動アセンブリは、The drive assembly includes:
前記送達部材内で、前記ハイドロゲルが前記流出開口部から運び出される前に前記高次構造の前記化学反応が完了するゲル化時間よりも長い送達時間内に、前記第１の成分及び前記第２の成分を、前記送達部材及び前記出口部分を通じて前記混合体積の中へ運ぶ、Within the delivery member, the first component and the second component within a delivery time longer than the gelling time for the chemical reaction of the conformation to complete before the hydrogel is transported out of the outflow opening. into the mixing volume through the delivery member and the outlet portion;
ように構成された、請求項１２に記載の装置。13. The apparatus of claim 12, configured to:
JP2021523237A 2018-11-13 2019-11-12 Systems and methods for delivering biomaterials Pending JP2022506078A (en)

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US201862760650P 2018-11-13 2018-11-13
US62/760,650 2018-11-13
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