JPWO2020097014A5 - - Google Patents

Info

Publication number

JPWO2020097014A5

JPWO2020097014A5 JP2021524012A JP2021524012A JPWO2020097014A5 JP WO2020097014 A5 JPWO2020097014 A5 JP WO2020097014A5 JP 2021524012 A JP2021524012 A JP 2021524012A JP 2021524012 A JP2021524012 A JP 2021524012A JP WO2020097014 A5 JPWO2020097014 A5 JP WO2020097014A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

aqueous extract

azadirachta indica

daily dosage

dosage range

Prior art date

2022-09-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 45
• 239000006286 aqueous extract Substances 0.000 claims 18
• 240000005343 Azadirachta indica Species 0.000 claims 15
• 235000013500 Melia azadirachta Nutrition 0.000 claims 15
• 230000008753 endothelial function Effects 0.000 claims 8
• 230000036765 blood level Effects 0.000 claims 7
• 206010012601 diabetes mellitus Diseases 0.000 claims 7
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 5
• 239000008280 blood Substances 0.000 claims 5
• 210000004369 blood Anatomy 0.000 claims 5
• 239000008103 glucose Substances 0.000 claims 5
• 108010074051 C-Reactive Protein Proteins 0.000 claims 4
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 4
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 239000000902 placebo Substances 0.000 claims 4
• 229940068196 placebo Drugs 0.000 claims 4
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
• 229930003935 flavonoid Natural products 0.000 claims 3
• 150000002215 flavonoids Chemical class 0.000 claims 3
• 235000017173 flavonoids Nutrition 0.000 claims 3
• CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 3
• 229960000367 inositol Drugs 0.000 claims 3
• 230000002265 prevention Effects 0.000 claims 3
• CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 3
• 102100032752 C-reactive protein Human genes 0.000 claims 2
• 206010022489 Insulin Resistance Diseases 0.000 claims 2
• 102000004889 Interleukin-6 Human genes 0.000 claims 2
• 108090001005 Interleukin-6 Proteins 0.000 claims 2
• WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 claims 2
• 229960003180 glutathione Drugs 0.000 claims 2
• 229940100601 interleukin-6 Drugs 0.000 claims 2
• 229940118019 malondialdehyde Drugs 0.000 claims 2
• 230000000291 postprandial effect Effects 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 206010048554 Endothelial dysfunction Diseases 0.000 claims 1
• 108010024636 Glutathione Proteins 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000008694 endothelial dysfunction Effects 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1