JPWO2020089918A5

JPWO2020089918A5 -

Info

Publication number: JPWO2020089918A5
Application number: JP2021524404A
Authority: JP
Publication date: 2022-11-14

Claims

A system for mixed imaging modalities including impedance-based analysis of a body part of a patient, comprising:
at least one multi-core bus bar, each bus bar of the at least one multi-core bus bar being connected to a controller and at least two of the plurality of sensing circuits ;
is a controller,
In each of the multiple iterations,
operating a pair of a first sensing circuit and a second sensing circuit of the plurality of sensing circuits, the pair of the first sensing circuit and the second sensing circuit being in a previous iteration of the plurality of iterations; not selected
the first sensing circuit is activated as a current source and the second sensing circuit is sequentially activated as a current sink;
Alternating current (AC) is supplied to the first detection circuit and the second detection circuit by sequentially activating detection circuits other than the first detection circuit and the second detection circuit among the plurality of detection circuits as voltage sensors. obtaining a plurality of surface voltages while flowing;
and the plurality of surface voltages and currents acquired at the plurality of iterations are provided to the calculation of a three-dimensional (3D) dataset of 3D impedance values of the body part to be analyzed. , the controller;
at least one hardware processor for generating an impedance-based in-body 3D conductivity mapping image of the body part from the 3D data set;
system with .

The controller sequentially activates each of the first sensing circuit and the second sensing circuit by transmitting a unique address associated with the first sensing circuit and the second sensing circuit over the at least one multicore bus bar. 2. The system of claim 1, wherein the system performs:

Each of the plurality of sensing circuits includes:
(i ) an address decoder activated when a unique address is transmitted over said at least one multicore busbar;
(ii) at least one electrode for contacting tissue;
(iii) at least one switch connecting said at least one electrode to one of said at least one multi-core busbars when said address decoder is activated by said unique address;
(iv) instructions for selectively operating at least one electrode as a current source, current sink, or voltage sensor on said at least one multi-core busbar when an address decoder is activated by a unique address; a designated mode decoder that receives from the one busbar of
2. The system of claim 1, comprising:

Each of the plurality of sensing circuits includes an amplifier for amplifying a voltage reading obtained by the at least one electrode when the specified mode decoder operates the at least one electrode as the voltage sensor. 4. The system of claim 3, further comprising:

The at least one busbar includes a transmitting circuit for delivering current to operate one of the plurality of sensing circuits as a current source, a receiving circuit for operating as a current mode, and a ground circuit representing ground. , at least one voltage circuit for transmitting a detected voltage from at least one voltage sensor, an address circuit for transmitting said unique address, and a clock circuit . The system described in .

a pressure surface coupled to the plurality of sensing circuits , the pressure surface including a pressing element adapted to press the plurality of sensing circuits to contact the body part with an acceptable uniform pressure; The system of claim 1.

Compute a computational model of a 3D data set of impedance values, and obtain the voltages acquired for each pair of current source and current sink during said plurality of iterations by a computational model comprising Laplace's equation incorporating the conductivity distribution. matching the calculated boundary values and iteratively adjusting the computational model containing the conductivity distribution until the obtained voltages and currents match the calculated boundary values within an error range; 2. The system of claim 1, further comprising at least one hardware processor.

An initial set of conductivity distribution values of the computational model of the 3D data set sequentially activates the first sensing circuit and the second sensing circuit from the plurality of sensing circuits such that current flows through the first sensing circuit and the 8. The system of claim 7 , obtained by the controller obtaining voltage readings from the first sensing circuit and the second sensing circuit while flowing between the second sensing circuit.

2. The system of claim 1, wherein the analysis of the body part by conductivity distribution mapping for tissue abnormality observation is for planning treatment of the patient.

2. The system of claim 1, wherein the body part includes one or two breasts, and the plurality of sensing circuits are arranged as a bra covering the one or two breasts.

further comprising a plurality of support elements positioned to contact and at least partially cover the body portion of the patient, wherein the at least one multicore busbar and the plurality of sensing circuits are attached to the plurality of support elements. are combined and
said plurality of support elements being in a partial or complete ring arrangement for encompassing at least discrete regions of said body part of said patient;
each individual support element of the plurality of support elements for connecting to at least two sensing circuits coupled to the individual support element and to a single main busbar connected to the controller; including one individual busbar,
The system of claim 1 .

the plurality of support elements arranged as extensions from a common area of the covering structure, each extension extending curvedly from the common area ;
the plurality of sensing circuits are automatically sequentially activated in a predetermined chaining manner to independently sequentially activate subsequent sensing circuits when the first sensing circuit is selected;
12. The system of claim 11.

3. The system of claim 1 , further comprising instructions for segmenting tissue suggestive of malignancy depicted in the impedance-based intrabody 3D conductivity mapping image.

14. The system of claim 13 , wherein the segmentation is performed by a machine learning model trained on a training dataset of multiple 3D conductivity images obtained from multiple sample patients.

The controller activates a sensing circuit other than the first sensing circuit and the second sensing circuit among the plurality of sensing circuits as the voltage sensor three times in each of the plurality of iterations to Obtaining multiple sets of voltage values at current frequencies, assigning each of the multiple sets of voltage values corresponding to different frequencies to a color channel, and mapping the impedance - based 3D body conductivity mapping image to the color channel. 2. The system of claim 1 , produced in color using the color channel.

The controller further sequentially activates at least some of the sensing circuits in an ultrasound mode to obtain ultrasound measurements and provide a plurality of ultrasound measurements to produce a 3D ultrasound intracorporeal image of the body portion. and designed to generate at least one of the conductivity mappings ,
The at least one hardware processor is configured to correlate the 3D dataset of impedance values to the plurality of ultrasound measurements to generate a correlated 3D image of the body portion based on the plurality of ultrasound measurements. 2. The system of claim 1 , wherein the system comprises :

the plurality of is further designed to operate in an ultrasonic mode, wherein the tissue electrode is selectively activated as the current source, the current sink or the voltage sensor, and in the ultrasonic mode the 2. The system of claim 1 , wherein the tissue electrode, said ultrasound element, and said second electrode are activated as an ultrasound transducer.

The at least one multicore busbar is
(i ) a master busbar connected to said plurality of sensing circuits arranged in a substantially circular configuration by a plurality of branched sub-busbars ;
(ii) a single continuous busbar with a staggered design ;
3. The system of claim 1 , comprising : (iii) at least one single continuous bus bar connecting said plurality of sensing circuits along a spiral arrangement .

A plurality of electrodes were arranged along the longitudinal axis of each support element of the plurality of support elements, each of said plurality of electrodes being connected to a main busbar connector designed to connect to said at least one multicore busbar. Addressing and switching circuitry, including individual conductors , for sequentially activating the plurality of electrodes is located connected to a main busbar connector, and a cup for the plurality of support elements to cover the body part. 2. The system of claim 1, arranged in a fan-like structure whose shape is designed to provide a shaped structure.

2. The system of claim 1, wherein the at least one multicore busbar includes less than ten conductors.

2. The system of claim 1, wherein the impedance-based in-body 3D conductivity mapping image comprises one or more two-dimensional (2D) parallel planes.

A method of impedance-based analysis of a body part of a patient, comprising:
providing at least one multi- core busbar connecting a plurality of sensing electrodes and each connected to a controller and at least two of the plurality of sensing electrodes ;
Iteratively performing sequential activation of current electrodes of pairs of said plurality of sensing electrodes at a time , wherein the plurality of voltages and currents obtained for each current electrode pair in each iteration are to be analyzed. provided for calculating a three-dimensional (3D) dataset of impedance values of body parts that
providing at least one hardware processor that generates an impedance-based in-body 3D conductivity mapping image of the body part from the 3D data set;
method including .