JPWO2020030670A5 - - Google Patents
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- Publication number
- JPWO2020030670A5 JPWO2020030670A5 JP2021506565A JP2021506565A JPWO2020030670A5 JP WO2020030670 A5 JPWO2020030670 A5 JP WO2020030670A5 JP 2021506565 A JP2021506565 A JP 2021506565A JP 2021506565 A JP2021506565 A JP 2021506565A JP WO2020030670 A5 JPWO2020030670 A5 JP WO2020030670A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- implantable biomaterial
- implantable
- biomaterial
- prepolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 poly(tetraethylene glycol) Polymers 0.000 claims 26
- 239000012620 biological material Substances 0.000 claims 21
- 229920000642 polymer Polymers 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 239000004970 Chain extender Substances 0.000 claims 10
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical group CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims 8
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 6
- 229960004337 hydroquinone Drugs 0.000 claims 6
- 239000004721 Polyphenylene oxide Substances 0.000 claims 5
- 229920000570 polyether Polymers 0.000 claims 5
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 claims 4
- 229920001400 block copolymer Polymers 0.000 claims 4
- 210000003709 heart valve Anatomy 0.000 claims 4
- 229920003226 polyurethane urea Polymers 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 229920002121 Hydroxyl-terminated polybutadiene Polymers 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 230000006835 compression Effects 0.000 claims 2
- 238000007906 compression Methods 0.000 claims 2
- WQPDQJCBHQPNCZ-UHFFFAOYSA-N cyclohexa-2,4-dien-1-one Chemical group O=C1CC=CC=C1 WQPDQJCBHQPNCZ-UHFFFAOYSA-N 0.000 claims 2
- 125000005442 diisocyanate group Chemical group 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- 229920002635 polyurethane Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- 229920001187 thermosetting polymer Polymers 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 206010052664 Vascular shunt Diseases 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000002169 extracardiac Effects 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 210000003041 ligament Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 239000004634 thermosetting polymer Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Claims (25)
ポリエーテル-ジイソシアネートプレポリマーを提供するステップ;
前記プレポリマーを1つ以上の鎖延長分子と反応させて、ポリウレタンポリマー、ポリウレタン-尿素ポリマーおよびポリウレタン-尿素ブロック共重合体から選択される成形可能なポリマーを形成するステップ;および
前記成形可能なポリマーを成形および硬化させて、移植可能な生体材料を形成するステップを含み、
前記ジイソシアネートがトルエンジイソシアネートである、移植可能な生体材料。 An implantable biomaterial formed by a method comprising:
providing a polyether-diisocyanate prepolymer;
reacting said prepolymer with one or more chain extension molecules to form a moldable polymer selected from polyurethane polymers, polyurethane-urea polymers and polyurethane-urea block copolymers; and said moldable polymer. to form an implantable biomaterial;
An implantable biomaterial, wherein said diisocyanate is toluene diisocyanate.
ポリエーテル-ジイソシアネートプレポリマーを提供するステップ;
前記プレポリマーを1つ以上の鎖延長分子と反応させて、ポリウレタンポリマー、ポリウレタン-尿素ポリマーおよびポリウレタン-尿素ブロック共重合体から選択される成形可能なポリマーを形成するステップ;および
前記成形可能なポリマーを成形および硬化させて、移植可能な生体材料を形成する、を含み、
前記ジイソシアネートがトルエンジイソシアネートである、方法。 A method of forming an implantable biomaterial comprising the steps of:
providing a polyether-diisocyanate prepolymer;
reacting said prepolymer with one or more chain extension molecules to form a moldable polymer selected from polyurethane polymers, polyurethane-urea polymers and polyurethane-urea block copolymers; and said moldable polymer. forming and curing to form an implantable biomaterial;
The method wherein said diisocyanate is toluene diisocyanate.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18187715.0A EP3607976A1 (en) | 2018-08-07 | 2018-08-07 | An implantable biomaterial, and method of manufacturing thereof |
EP18187715.0 | 2018-08-07 | ||
PCT/EP2019/071171 WO2020030670A1 (en) | 2018-08-07 | 2019-08-07 | An implantable biomaterial, and method of manufacturing thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021532938A JP2021532938A (en) | 2021-12-02 |
JPWO2020030670A5 true JPWO2020030670A5 (en) | 2022-08-16 |
JP7446281B2 JP7446281B2 (en) | 2024-03-08 |
Family
ID=63168329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021506565A Active JP7446281B2 (en) | 2018-08-07 | 2019-08-07 | Implantable biomaterials and their manufacturing methods |
Country Status (6)
Country | Link |
---|---|
US (1) | US20210299324A1 (en) |
EP (3) | EP3607976A1 (en) |
JP (1) | JP7446281B2 (en) |
CN (1) | CN112739390A (en) |
ES (1) | ES2936213T3 (en) |
WO (1) | WO2020030670A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10995298B2 (en) | 2014-07-23 | 2021-05-04 | Becton, Dickinson And Company | Self-lubricating polymer composition |
US11613719B2 (en) | 2018-09-24 | 2023-03-28 | Becton, Dickinson And Company | Self-lubricating medical articles |
CN114957597A (en) | 2021-02-25 | 2022-08-30 | 贝克顿·迪金森公司 | Polyurethane-type medical article |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6015335B2 (en) * | 1981-09-02 | 1985-04-18 | 東洋紡績株式会社 | blood handling equipment |
US5116931A (en) * | 1990-09-28 | 1992-05-26 | Olin Corporation | Thermoset polyurethane elastomers and polyurea elastomers made using high functionality, low unsaturation level polyols prepared with double metal cyanide catalysts |
JPH06192382A (en) * | 1992-12-22 | 1994-07-12 | Mitsubishi Cable Ind Ltd | Antithrombotic polyurethane elastomer and medical equipment using the same |
WO1999024084A1 (en) * | 1997-11-07 | 1999-05-20 | Salviac Limited | Biostable polycarbonate urethane products |
US7799255B2 (en) * | 2003-06-30 | 2010-09-21 | Lubrizol Advanced Materials, Inc. | Melt spun elastic tape and process |
CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
US20060276613A1 (en) * | 2005-05-12 | 2006-12-07 | Iskender Yilgor | Polyurethaneurea segmented copolymers |
JP4986274B2 (en) * | 2005-06-03 | 2012-07-25 | 東洋ゴム工業株式会社 | Polishing pad and manufacturing method thereof |
EP1919398B1 (en) * | 2005-07-29 | 2014-03-05 | Cook Medical Technologies LLC | Elliptical implantable device |
US20100152405A1 (en) * | 2005-12-06 | 2010-06-17 | E.I. Du Pont De Nemours And Company | Thermoplastic polyurethanes comprising polytrimethylene ether soft segments |
EP2049172B1 (en) * | 2006-07-25 | 2014-12-31 | Coloplast A/S | Photo-curing of thermoplastic coatings |
EP2585497B1 (en) * | 2010-06-22 | 2023-08-09 | Coloplast A/S | Hydrophilic gels from polyurethane-based photoinitiators |
-
2018
- 2018-08-07 EP EP18187715.0A patent/EP3607976A1/en not_active Withdrawn
-
2019
- 2019-08-07 ES ES19762321T patent/ES2936213T3/en active Active
- 2019-08-07 EP EP22199129.2A patent/EP4169538A1/en active Pending
- 2019-08-07 EP EP19762321.8A patent/EP3833408B1/en active Active
- 2019-08-07 US US17/266,227 patent/US20210299324A1/en active Pending
- 2019-08-07 WO PCT/EP2019/071171 patent/WO2020030670A1/en active Search and Examination
- 2019-08-07 JP JP2021506565A patent/JP7446281B2/en active Active
- 2019-08-07 CN CN201980062406.3A patent/CN112739390A/en active Pending
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