JPWO2020030670A5 - - Google Patents

Claims (25)

An implantable biomaterial formed by a method comprising:
providing a polyether-diisocyanate prepolymer;
reacting said prepolymer with one or more chain extension molecules to form a moldable polymer selected from polyurethane polymers, polyurethane-urea polymers and polyurethane-urea block copolymers; and said moldable polymer. to form an implantable biomaterial;
An implantable biomaterial, wherein said diisocyanate is toluene diisocyanate. 2. The implantable biomaterial of claim 1, wherein said one or more chain extension molecules comprises benzene-1,4-diol. reacting said prepolymer with two chain extenders comprising benzene-1,4-diol and one chain extender with amino functionality, optionally said chain extender with amino functionality , p-phenylenediamine. poly(tetraethylene glycol); poly(tetramethylene glycol); hydroxyl-terminated poly(dimethylsiloxane); hydroxy-terminated polybutadiene; polybutylene adipate and polycaprolactone; An implantable biomaterial according to any one of claims 1 to 3, selected from the group consisting of: 2. The implantable biomaterial of claim 1, wherein said toluene diisocyanate is 2,4 toluene diisocyanate. The prepolymer is reacted with two chain extenders containing benzene-1,4-diol and p-phenylenediamine, and the polyether is poly(propylene glycol), poly(ethylene glycol), poly(tetra The implantable biomaterial according to any one of claims 1 to 5, which is a polyether selected from poly(tetramethylene glycol) and poly(tetramethylene glycol). The implantable device according to any one of claims 1 to 6, wherein the weight ratio of toluene diisocyanate, polyether and chain extender in said block copolymer is 2-6:1-3:1-3. biomaterial. An implantable biomaterial according to any one of the preceding claims, wherein said moldable polymer is molded in an implantable biomaterial mold. An implantable biomaterial according to any one of the preceding claims, wherein said moldable polymer is cured in an implantable biomaterial mold. The implantable organism according to any one of claims 1 to 9, selected from valves or leaflets, implantable conduits, cardiac assist devices, stents, tissue prostheses, catheters, balloons, shunts or fibers. material. 11. The implantable biomaterial of claim 10, wherein said valve is a heart valve. 12. The implantable biomaterial of claim 11, wherein the heart valve is a percutaneously delivered heart valve. An implant comprising an implantable biomaterial according to any one of claims 1 to 9, said implant being an artificial heart, an extracardiac compression device, an intravascular or extravascular compression device, a heart valve prosthesis. , annuloplasty rings, skin grafts, vascular grafts, vascular stents, structural stents, vascular shunts, cardiovascular shunts, dural grafts, cartilage grafts, cartilage grafts, pericardial grafts, ligament prostheses, tendon prostheses, A graft selected from bladder prostheses, pledgets, permanently indwelling percutaneous devices, surgical patches, cardiovascular stents, coated stents, and coated catheters. A method of forming an implantable biomaterial comprising the steps of:
providing a polyether-diisocyanate prepolymer;
reacting said prepolymer with one or more chain extension molecules to form a moldable polymer selected from polyurethane polymers, polyurethane-urea polymers and polyurethane-urea block copolymers; and said moldable polymer. forming and curing to form an implantable biomaterial;
The method wherein said diisocyanate is toluene diisocyanate. 15. The method of claim 14, wherein said one or more chain extension molecules is benzene-1,4-diol. reacting said prepolymer with two chain extenders comprising benzene-1,4-diol and one chain extender with amino functionality, optionally said chain extender with amino functionality is p-phenylenediamine. poly(tetraethylene glycol); poly(tetramethylene glycol); hydroxyl-terminated poly(dimethylsiloxane); hydroxy-terminated polybutadiene; polybutylene adipate and polycaprolactone; A method according to any one of claims 14 to 16, selected from the group consisting of The method of any one of claims 14-17, wherein the toluene diisocyanate is 2,4 toluene diisocyanate. The prepolymer is two chain extenders comprising benzene-1,4-diol and p-phenylenediamine, and the polyether is a poly(ethylene glycol) selected from poly(propylene glycol) or poly(ethylene glycol). A method according to any one of claims 14 to 18, which is an ether. The method according to any one of claims 14-19, wherein the weight ratio of toluene diisocyanate, polyether and chain extender in the block copolymer is 2-6:1-3:1-3. The method of any one of claims 14-20, wherein the moldable polymer is molded in an implantable biomaterial mold. The method of any one of claims 15-21, wherein the moldable polymer is cured in an implantable biomaterial mold. An implantable biomaterial formed by the method of any one of claims 14-22. Implantable biomaterial according to any one of claims 1 to 12, wherein said moldable polymer is a thermosetting polymer. A method according to any one of claims 14 to 22, wherein said moldable polymer is a thermoset polymer.