JPWO2020028608A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020028608A5 JPWO2020028608A5 JP2021505800A JP2021505800A JPWO2020028608A5 JP WO2020028608 A5 JPWO2020028608 A5 JP WO2020028608A5 JP 2021505800 A JP2021505800 A JP 2021505800A JP 2021505800 A JP2021505800 A JP 2021505800A JP WO2020028608 A5 JPWO2020028608 A5 JP WO2020028608A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- cancer
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Claims (17)
各X1は、独立して、NまたはCR2であり;
X2は、O、CH2、NH、SまたはN(C1-C3アルキル)であり;
R1は、H、CH3(CH2)1-3、CH3(CH2)0-1O(CH2)2-3、CH3(CH2)0-3C(=O)、CH3(CH2)0-1O(CH2)2-3C(=O)、
R2は、H、O(C1-C3アルキル)、C1-C3アルキル、Cl、FまたはCNであり;
R3は、H、ハロ、OH、CN、NH2、NH(C1-C5アルキル)、N(C1-C5アルキル)2、NH(CH2)0-1(C3-C6シクロアルキル)、NH(C4-C8ビシクロアルキル)、NH(C6-C10スピロシクロアルキル)、N(C3-C6シクロアルキル)2、NH(CH2)1-3(アリール)、N((CH2)1-3(アリール))2、構造:
ここで、アルキル、シクロアルキル、ビシクロアルキル、スピロシクロアルキル、環状アミン、6員環の芳香族基またはヘテロ芳香族基、あるいは5員環のヘテロ芳香族基は、所望により、OH、ハロ、CN、(C1-C3アルキル)、O(C1-C3アルキル)、C(=O)(Me)、SO2(C1-C3アルキル)、C(=O)(Et)、NH2、NH(Me)、N(Me)2、NH(Et)、N(Et)2およびN(C1-C3アルキル)、(CH2)1-2OH、(CH2)1-2OMeから選択される1以上の置換基で置換されていてもよく;および
シクロアルキル、ビシクロアルキル、スピロシクロアルキルまたは環状アミン基は、O、S、NH、N(C1-C3アルキル)またはN(Boc)により置換されたCH2基を有してもよく;
mは、0または1であり;および
nは、1、2または3である]
の構造を有する、化合物またはその医薬的に許容される塩。 Formula I:
each X 1 is independently N or CR 2 ;
X 2 is O, CH 2 , NH, S or N(C 1 -C 3 alkyl);
R 1 is H, CH 3 (CH 2 ) 1-3 , CH 3 (CH 2 ) 0-1 O(CH 2 ) 2-3 , CH 3 (CH 2 ) 0-3 C(=O), CH 3 (CH 2 ) 0-1 O(CH 2 ) 2-3 C(=O),
R 2 is H, O(C 1 -C 3 alkyl), C 1 -C 3 alkyl, Cl, F or CN;
R 3 is H, halo, OH, CN, NH 2 , NH(C 1 -C 5 alkyl), N(C 1 -C 5 alkyl) 2 , NH(CH 2 ) 0-1 (C 3 -C 6 cycloalkyl), NH(C 4 -C 8 bicycloalkyl), NH(C 6 -C 10 spirocycloalkyl), N(C 3 -C 6 cycloalkyl) 2 , NH(CH 2 ) 1-3 (aryl) , N((CH 2 ) 1-3 (aryl)) 2 , structure:
wherein alkyl, cycloalkyl, bicycloalkyl, spirocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic group, or 5-membered heteroaromatic group is optionally OH, halo, CN , (C 1 -C 3 alkyl), O(C 1 -C 3 alkyl), C(=O)(Me), SO 2 (C 1 -C 3 alkyl), C(=O)(Et), NH 2 , NH(Me), N(Me) 2 , NH(Et), N(Et) 2 and N(C 1 -C 3 alkyl), (CH 2 ) 1-2 OH, (CH 2 ) 1-2 optionally substituted with one or more substituents selected from OMe; and the cycloalkyl, bicycloalkyl, spirocycloalkyl or cyclic amine groups are O, S, NH, N(C 1 -C 3 alkyl) or may have a CH2 group substituted by N(Boc);
m is 0 or 1; and n is 1, 2 or 3]
or a pharmaceutically acceptable salt thereof, having the structure
である、請求項9記載の化合物またはその医薬的に許容される塩。 R 1 is
10. The compound of claim 9, or a pharmaceutically acceptable salt thereof, which is
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2023135510A JP2023182569A (en) | 2018-08-03 | 2023-08-23 | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862714238P | 2018-08-03 | 2018-08-03 | |
US62/714,238 | 2018-08-03 | ||
US16/527,802 | 2019-07-31 | ||
US16/527,802 US11554120B2 (en) | 2018-08-03 | 2019-07-31 | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
PCT/US2019/044575 WO2020028608A1 (en) | 2018-08-03 | 2019-08-01 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023135510A Division JP2023182569A (en) | 2018-08-03 | 2023-08-23 | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021532162A JP2021532162A (en) | 2021-11-25 |
JPWO2020028608A5 true JPWO2020028608A5 (en) | 2022-08-05 |
JP7337907B2 JP7337907B2 (en) | 2023-09-04 |
Family
ID=67742964
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021505800A Active JP7337907B2 (en) | 2018-08-03 | 2019-08-01 | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses thereof |
JP2021505870A Active JP7337909B2 (en) | 2018-08-03 | 2019-08-01 | 2H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses thereof |
JP2023135513A Pending JP2023179420A (en) | 2018-08-03 | 2023-08-23 | 2H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR |
JP2023135510A Pending JP2023182569A (en) | 2018-08-03 | 2023-08-23 | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021505870A Active JP7337909B2 (en) | 2018-08-03 | 2019-08-01 | 2H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses thereof |
JP2023135513A Pending JP2023179420A (en) | 2018-08-03 | 2023-08-23 | 2H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR |
JP2023135510A Pending JP2023182569A (en) | 2018-08-03 | 2023-08-23 | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
Country Status (19)
Country | Link |
---|---|
US (3) | US11554120B2 (en) |
EP (2) | EP3830090B1 (en) |
JP (4) | JP7337907B2 (en) |
KR (2) | KR20210039411A (en) |
CN (2) | CN112513046A (en) |
AR (1) | AR115885A1 (en) |
AU (1) | AU2019314444A1 (en) |
BR (1) | BR112021001503A2 (en) |
CA (1) | CA3108512A1 (en) |
CL (1) | CL2021000216A1 (en) |
CO (1) | CO2021000942A2 (en) |
EA (1) | EA202190442A1 (en) |
ES (2) | ES2941520T3 (en) |
IL (1) | IL280473A (en) |
MX (1) | MX2021001311A (en) |
PE (1) | PE20211812A1 (en) |
SG (1) | SG11202101031XA (en) |
TW (1) | TW202019933A (en) |
WO (2) | WO2020028610A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230149857A (en) | 2016-07-07 | 2023-10-27 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Antibody adjuvant conjugates |
AU2017382339B2 (en) | 2016-12-22 | 2024-02-15 | Novartis Ag | NMDA receptor modulators and uses thereof |
EA202190431A1 (en) | 2018-08-03 | 2021-06-11 | Кэйдент Терапьютикс, Инк. | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND THEIR APPLICATION |
US11554120B2 (en) * | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
CN115135655B (en) * | 2020-01-27 | 2024-07-02 | 百时美施贵宝公司 | 1H-pyrazolo [4,3-d ] pyrimidine compounds as Toll-like receptor 7 (TLR 7) agonists |
CN115210236A (en) * | 2020-01-27 | 2022-10-18 | 百时美施贵宝公司 | 1H-pyrazolo [4,3-d ] pyrimidine compounds as Toll-like receptor 7 (TLR 7) agonists |
US20230144824A1 (en) | 2020-01-27 | 2023-05-11 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
EP4097103A1 (en) | 2020-01-27 | 2022-12-07 | Bristol-Myers Squibb Company | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
US20230127326A1 (en) * | 2020-01-27 | 2023-04-27 | Bristol-Myers Squibb Company | C3-SUBSTITUTED 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
WO2021154663A1 (en) | 2020-01-27 | 2021-08-05 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
KR20220132601A (en) | 2020-01-27 | 2022-09-30 | 브리스톨-마이어스 스큅 컴퍼니 | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists |
WO2021154664A1 (en) | 2020-01-27 | 2021-08-05 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
JP2023512206A (en) | 2020-01-27 | 2023-03-24 | ブリストル-マイヤーズ スクイブ カンパニー | 1H-pyrazolo[4,3-d]pyrimidine compounds as Toll-like receptor 7 (TLR7) agonists |
WO2021247809A1 (en) * | 2020-06-04 | 2021-12-09 | Merck Sharp & Dohme Corp. | PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS |
CN114805392A (en) * | 2021-01-20 | 2022-07-29 | 上海维申医药有限公司 | Macrocyclic TLR7 agonist, preparation method thereof, pharmaceutical composition and application thereof |
EP4331616A1 (en) * | 2021-05-13 | 2024-03-06 | Tsinghua University | Antibody drug conjugate, preparation method therefor and application thereof |
Family Cites Families (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
US4698420A (en) | 1985-02-25 | 1987-10-06 | Xoma Corporation | Antibody hybrid molecules and process for their preparation |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
NZ329798A (en) | 1996-07-03 | 1999-04-29 | Japan Energy Corp | Purine derivatives their tautomers and salts thereof and interferon secretion inducers, antiviral agents and anticancer drugs containing the same |
TW572758B (en) | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
CA2381770C (en) | 1999-08-24 | 2007-08-07 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
US7402556B2 (en) | 2000-08-24 | 2008-07-22 | Medarex, Inc. | Prodrugs activated by plasmin and their use in cancer chemotherapy |
US7571211B1 (en) | 2002-04-15 | 2009-08-04 | Lightwaves Systems, Inc. | Method for routing messages over a network based on location |
JP4331944B2 (en) | 2001-04-17 | 2009-09-16 | 大日本住友製薬株式会社 | New adenine derivatives |
US7087600B2 (en) | 2001-05-31 | 2006-08-08 | Medarex, Inc. | Peptidyl prodrugs and linkers and stabilizers useful therefor |
US6897034B2 (en) | 2001-06-11 | 2005-05-24 | Medarex, Inc. | CD10-activated prodrug compounds |
US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
EP2336133A1 (en) | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
NZ534174A (en) | 2002-01-09 | 2007-03-30 | Medarex Inc | An isolated human monoclonal antibody which binds to human CD30 |
CA2497765A1 (en) | 2002-09-27 | 2004-04-08 | Sumitomo Pharmaceuticals Co., Ltd. | 8-hydroxy substituted adenine compounds and uses thereof |
JP2004137157A (en) | 2002-10-16 | 2004-05-13 | Sumitomo Pharmaceut Co Ltd | Medicine comprising new adenine derivative as active ingredient |
EP1613274B1 (en) | 2003-04-15 | 2010-03-03 | GlaxoSmithKline LLC | Human il-18 substitution mutants and their conjugates |
UY28424A1 (en) | 2003-07-22 | 2005-02-28 | Schering Ag | RGI ANTIBODIES AND USES OF THE SAME. |
WO2005051976A2 (en) | 2003-11-20 | 2005-06-09 | Ansata Therapeutics, Inc. | Protein and peptide ligation processes and one-step purification processes |
EP2865687A1 (en) | 2003-12-10 | 2015-04-29 | E. R. Squibb & Sons, L.L.C. | IP-10 antibodies and their uses |
EP1718667B1 (en) | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
EP2053062A1 (en) | 2004-03-24 | 2009-04-29 | Xencor, Inc. | Immunoglobin variants outside the Fc region |
JPWO2005092892A1 (en) | 2004-03-26 | 2008-02-14 | 大日本住友製薬株式会社 | 8-Oxoadenine compounds |
US7691962B2 (en) | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
NZ550934A (en) | 2004-05-19 | 2010-05-28 | Medarex Inc | Chemical linkers and conjugates thereof |
ES2579805T3 (en) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Antibodies and conjugates engineered with cysteine |
WO2006046135A2 (en) | 2004-10-28 | 2006-05-04 | Pharmacia & Upjohn Company Llc | Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors |
CN101124249B (en) | 2005-02-18 | 2011-06-29 | 米德列斯公司 | Human monoclonal antibodies to prostate specific membrane antigen(PSMA) |
JP5249587B2 (en) | 2005-02-18 | 2013-07-31 | メダレックス, インク. | Monoclonal antibody against prostate specific membrane antigen (PSMA) lacking fucosyl residues |
US7714016B2 (en) | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
AU2006242920A1 (en) | 2005-05-04 | 2006-11-09 | Pfizer Limited | 2-amido-6-amino-8-oxopurine derivatives as Toll-Like receptor modulators for the treatment of cancer and viral infections, such as hepatitis C |
PL2439273T3 (en) | 2005-05-09 | 2019-08-30 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
CA2611814A1 (en) | 2005-06-20 | 2007-01-04 | Medarex, Inc. | Cd19 antibodies and their uses |
CN104356236B (en) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | Human monoclonal antibodies to programmed death ligand 1(PD-L1) |
CA2616005C (en) | 2005-07-18 | 2015-09-22 | Seattle Genetics, Inc. | Beta-glucuronide-linker drug conjugates |
WO2007028129A1 (en) | 2005-09-02 | 2007-03-08 | Pfizer Inc. | Hydroxy substituted 1h-imidazopyridines and methods |
US20090118263A1 (en) | 2005-09-22 | 2009-05-07 | Dainippon Sumitomo Pharma Co., Ltd. | Novel Adenine Compound |
JPWO2007034917A1 (en) | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | New adenine compounds |
NZ566395A (en) | 2005-09-26 | 2012-03-30 | Medarex Inc | Human monoclonal antibodies to CD70 |
CA2623652C (en) | 2005-09-26 | 2013-11-26 | Medarex, Inc. | Antibody-drug conjugates and methods of use |
EP1940789B1 (en) | 2005-10-26 | 2011-11-23 | Medarex, Inc. | Methods and compounds for preparing cc-1065 analogs |
WO2007059404A2 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
AU2006321553B2 (en) | 2005-12-08 | 2012-03-08 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to O8E |
SG177194A1 (en) | 2005-12-08 | 2012-01-30 | Medarex Inc | Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies |
WO2007093901A1 (en) | 2006-02-17 | 2007-08-23 | Pfizer Limited | 3 -deazapurine derivatives as tlr7 modulators |
AU2007325952B8 (en) | 2006-06-29 | 2013-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-free synthesis of proteins containing unnatural amino acids |
EP2054435A1 (en) | 2006-08-18 | 2009-05-06 | Novo Nordisk Health Care AG | Transglutaminase variants with improved specificity |
CN104328086A (en) | 2006-09-08 | 2015-02-04 | Ambrx公司 | Site Specific Incorporation of Non-Natural Amino Acids by Vertebrate Cells |
TWI522366B (en) | 2006-10-02 | 2016-02-21 | E R 施貴寶&聖斯有限責任公司 | Human antibodies that bind cxcr4 and uses thereof |
NZ578064A (en) | 2006-12-01 | 2012-01-12 | Medarex Inc | Human antibodies that bind cd22 and uses thereof |
UY30776A1 (en) | 2006-12-21 | 2008-07-03 | Medarex Inc | CD44 ANTIBODIES |
TWI412367B (en) | 2006-12-28 | 2013-10-21 | Medarex Llc | Chemical linkers and cleavable substrates and conjugates thereof |
BRPI0807196A2 (en) | 2007-02-07 | 2014-06-03 | Univ California | METHOD TO PREVENT OR INHIBIT A BACTERIAL, VACCINE, COMPOUND INFECTION, AND METHOD TO PREVENT, TREAT OR INHIBIT ASTHMA |
KR20090122439A (en) | 2007-02-21 | 2009-11-30 | 메다렉스, 인코포레이티드 | Chemical linkers with single amino acids and conjugates thereof |
JP2010518843A (en) | 2007-02-22 | 2010-06-03 | ノボ ノルディスク ヘルス ケア アーゲー | Transglutaminase variants with improved specificity |
PE20081887A1 (en) | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | NEW ADENINE COMPOUND |
MX2009009913A (en) | 2007-03-23 | 2009-10-16 | Amgen Inc | Derivatives of quinoline or benzopyrazine and their uses for the treatment of (inter alia) inflammatory diseases, autoimmune diseases or various kinds of cancer. |
US7968544B2 (en) | 2007-06-29 | 2011-06-28 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
EP2188280B1 (en) | 2007-08-03 | 2011-03-09 | Pfizer Limited | Imidazopyridinones |
WO2009026274A1 (en) | 2007-08-22 | 2009-02-26 | Medarex, Inc. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
US8268970B2 (en) | 2007-10-01 | 2012-09-18 | Bristol-Myers Squibb Company | Human antibodies that bind mesothelin, and uses thereof |
CN102272134B (en) | 2008-12-09 | 2013-10-16 | 吉里德科学公司 | Modulators of toll-like receptors |
WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
MX2011008500A (en) | 2009-02-11 | 2011-09-26 | Univ California | Toll-like receptor modulators and treatment of diseases. |
SI2491035T1 (en) | 2009-10-22 | 2017-10-30 | Gilead Sciences, Inc. | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
WO2011134668A1 (en) | 2010-04-30 | 2011-11-03 | Telormedix Sa | Phospholipid drug analogs |
JP2013525431A (en) | 2010-04-30 | 2013-06-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Use of phospholipid conjugates of synthetic TLR7 agonists |
WO2011134669A1 (en) | 2010-04-30 | 2011-11-03 | Telormedix Sa | Methods for inducing an immune response |
US20120083473A1 (en) | 2010-09-21 | 2012-04-05 | Johanna Holldack | Treatment of conditions by toll-like receptor modulators |
EP2635310A2 (en) | 2010-11-05 | 2013-09-11 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
WO2012122396A1 (en) | 2011-03-08 | 2012-09-13 | Baylor Research Institute | Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells |
CN103702687A (en) | 2011-07-29 | 2014-04-02 | 西莱克塔生物科技公司 | Synthetic nanocarriers that generate humoral and cytotoxic T lymphocyte (CTL) immune responses |
US9556176B2 (en) | 2011-11-09 | 2017-01-31 | Janssen Sciences Ireland Uc | Purine derivatives for the treatment of viral infections |
KR102207888B1 (en) | 2012-07-13 | 2021-01-26 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Macrocyclic purines for the treatment of viral infections |
JP6196674B2 (en) | 2012-08-24 | 2017-09-13 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | Pyrazolopyrimidine compounds |
SG11201502622VA (en) | 2012-10-10 | 2015-05-28 | Janssen Sciences Ireland Uc | PYRROLO[3,2-<i>D</i>]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES |
EP2732825B1 (en) | 2012-11-19 | 2015-07-01 | Invivogen | Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist |
CA2900854C (en) | 2013-02-14 | 2017-08-22 | Bristol-Myers Squibb Company | Tubulysin compounds, methods of making and use |
US9295732B2 (en) | 2013-02-22 | 2016-03-29 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
EA202090547A3 (en) | 2013-03-29 | 2020-12-30 | Янссен Сайенсиз Айрлэнд Юси | MACROCYCLIC DEASE-OXIPURINS FOR TREATMENT OF VIRAL INFECTIONS |
US10385054B2 (en) | 2013-06-27 | 2019-08-20 | Janssen Sciences Ireland Unlimited Company | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
WO2015023858A2 (en) | 2013-08-16 | 2015-02-19 | The Regents Of The University Of California | Uses of phospholipid conjugates of synthetic tlr7 agonists |
WO2015036044A1 (en) | 2013-09-13 | 2015-03-19 | Telormedix Sa | Cationic lipid vehicles for delivery of tlr7 agonists for specific targeting of human cd14+ monocytes in whole blood |
US9944649B2 (en) | 2014-05-01 | 2018-04-17 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists |
MX362341B (en) | 2014-05-01 | 2019-01-11 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists. |
WO2015171527A1 (en) * | 2014-05-05 | 2015-11-12 | Global Blood Therapeutics, Inc. | Pyrazolopyridine pyrazolopyrimidine and related compounds |
AU2015303558B2 (en) | 2014-08-15 | 2018-07-12 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pyrrolopyrimidine compounds used as TLR7 agonist |
CN105732635A (en) | 2014-12-29 | 2016-07-06 | 南京明德新药研发股份有限公司 | Toll-like receptor 7 agonist |
WO2016144608A1 (en) | 2015-03-10 | 2016-09-15 | Bristol-Myers Squibb Company | Antibodies conjugatable by transglutaminase and conjugates made therefrom |
JP2018531935A (en) | 2015-10-02 | 2018-11-01 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Transglutaminase variants for antibody binding |
MA44334A (en) | 2015-10-29 | 2018-09-05 | Novartis Ag | ANTIBODY CONJUGATES INCLUDING A TOLL-TYPE RECEPTOR AGONIST |
US10676478B2 (en) | 2015-11-05 | 2020-06-09 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 7-(thiazol-5-yl) pyrrolopyrimidine compound as TLR7 agonist |
US20170166384A1 (en) | 2015-12-11 | 2017-06-15 | Graphic Packaging International, Inc. | Container with absorption features |
AU2017286380B2 (en) | 2016-06-16 | 2021-02-04 | Janssen Pharmaceutica Nv | Azabenzimidazole derivatives as PI3K beta inhibitors |
BR112019004560A2 (en) | 2016-09-13 | 2019-07-02 | Hoffmann La Roche | combination treatment with tlr7 agonist and a hbv capsid formation inhibitor |
WO2018095426A1 (en) | 2016-11-28 | 2018-05-31 | 江苏恒瑞医药股份有限公司 | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof |
US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
CA3085424A1 (en) | 2017-12-21 | 2019-06-27 | Sumitomo Dainippon Pharma Co., Ltd. | Combination drug including tlr7 agonist |
WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
US11554120B2 (en) * | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
US11664120B1 (en) * | 2020-05-11 | 2023-05-30 | Walgreen Co. | Apparatuses, systems, and methods for reducing return of prescriptions to stock |
-
2019
- 2019-07-31 US US16/527,802 patent/US11554120B2/en active Active
- 2019-08-01 ES ES19759090T patent/ES2941520T3/en active Active
- 2019-08-01 MX MX2021001311A patent/MX2021001311A/en unknown
- 2019-08-01 CN CN201980051044.8A patent/CN112513046A/en active Pending
- 2019-08-01 CN CN201980062888.2A patent/CN112752759A/en active Pending
- 2019-08-01 WO PCT/US2019/044578 patent/WO2020028610A1/en unknown
- 2019-08-01 JP JP2021505800A patent/JP7337907B2/en active Active
- 2019-08-01 WO PCT/US2019/044575 patent/WO2020028608A1/en active Application Filing
- 2019-08-01 US US16/529,457 patent/US11400094B2/en active Active
- 2019-08-01 BR BR112021001503-5A patent/BR112021001503A2/en unknown
- 2019-08-01 JP JP2021505870A patent/JP7337909B2/en active Active
- 2019-08-01 AR ARP190102180A patent/AR115885A1/en unknown
- 2019-08-01 EA EA202190442A patent/EA202190442A1/en unknown
- 2019-08-01 EP EP19759090.4A patent/EP3830090B1/en active Active
- 2019-08-01 AU AU2019314444A patent/AU2019314444A1/en not_active Abandoned
- 2019-08-01 KR KR1020217005766A patent/KR20210039411A/en unknown
- 2019-08-01 PE PE2021000126A patent/PE20211812A1/en unknown
- 2019-08-01 EP EP19758854.4A patent/EP3830089B1/en active Active
- 2019-08-01 ES ES19758854T patent/ES2941768T3/en active Active
- 2019-08-01 CA CA3108512A patent/CA3108512A1/en active Pending
- 2019-08-01 SG SG11202101031XA patent/SG11202101031XA/en unknown
- 2019-08-01 KR KR1020217005765A patent/KR20210039410A/en unknown
- 2019-08-02 TW TW108127543A patent/TW202019933A/en unknown
-
2021
- 2021-01-27 CL CL2021000216A patent/CL2021000216A1/en unknown
- 2021-01-28 CO CONC2021/0000942A patent/CO2021000942A2/en unknown
- 2021-01-28 IL IL280473A patent/IL280473A/en unknown
-
2022
- 2022-12-14 US US18/081,558 patent/US20230140047A1/en active Pending
-
2023
- 2023-08-23 JP JP2023135513A patent/JP2023179420A/en active Pending
- 2023-08-23 JP JP2023135510A patent/JP2023182569A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPWO2020028608A5 (en) | ||
JPWO2020028610A5 (en) | ||
RU2468021C2 (en) | Heterocyclic compounds and their application | |
US20210346375A1 (en) | Process of manufacture of a compound for inhibiting the activity of shp2, as well as products resulting from acid addition | |
CN106458930B (en) | 2- amino-metadiazine compound and its pharmaceutical composition and application | |
AU2021354823A1 (en) | Antitumor compound, and preparation method therefor and use thereof | |
JP2018528261A5 (en) | ||
US11192900B2 (en) | Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors | |
JP2014534200A5 (en) | ||
RU2015118647A (en) | AMINOPYRIMIDINE COMPOUNDS AS T790M MUTANT EGFR INHIBITORS | |
RU2020102453A (en) | Pharmaceutical compositions | |
JP2014524441A5 (en) | ||
JP2021510733A (en) | Combination of selective histone deacetylase 3 (HDAC3) inhibitor and immunotherapeutic agent for the treatment of cancer | |
KR20220035955A (en) | Macrocyclic compounds as STING agonists and methods and uses thereof | |
CN111406050B (en) | Indoleamine 2, 3-dioxygenase inhibitors and uses thereof | |
RU2011108485A (en) | NEW (POLY) AMINOalkylaminoalkylamide, Alkylurea Or Alkylsulfonamide Derivatives Epipodophyllotoxin, A METHOD FOR PRODUCING THEM AND USING THERAPY AS AN INTERMEDIATE | |
US11390613B2 (en) | Azole analogues and methods of use thereof | |
JPWO2020092907A5 (en) | ||
JPWO2019213445A5 (en) | ||
JP2010535203A5 (en) | ||
JPWO2020173935A5 (en) | ||
US10111955B2 (en) | PEG derivative | |
US10421769B2 (en) | Anticancer property studies of chiral palladium N-heterocyclic carbene complexes and process for preparation thereof | |
JPWO2021154669A5 (en) | ||
RU2006142740A (en) | THYNOPYRIDAZINES AS IKK INHIBITORS |