JPWO2020025560A5

JPWO2020025560A5 -

Info

Publication number: JPWO2020025560A5
Application number: JP2021503877A
Authority: JP
Publication date: 2022-07-29

Claims

A method of obtaining activation data specific to anatomy in a patient's brain, comprising:
receiving magnetic resonance data of the brain acquired by use of a magnetic resonance imaging device , said magnetic resonance data comprising magnetic resonance data of anatomy within the patient's brain ;
segmenting the brain magnetic resonance data to delineate a plurality of geometries, each of the plurality of geometries corresponding to a respective anatomical structure within the brain; is based on a shape-constrained deformable 3D brain model, comprising adapting the 3D brain model to the anatomy in said brain ;
receiving functional magnetic resonance data of the brain obtained by use of a magnetic resonance imaging device;
aligning the magnetic resonance data and the functional magnetic resonance data;
determining a plurality of activation levels based on the aligned magnetic resonance data and the functional magnetic resonance data, each of the plurality of activation levels corresponding to a respective delineated geometry; do, step and
determining a sequence of activations of the anatomical structure based on the contoured geometry and corresponding activation levels, the sequence of activations comprising the magnetic resonance data and functional magnetic resonance data; a step determined based on the order or timing of
determining propagation of activity from one delineated geometry to another delineated geometry based on the delineated geometries and corresponding activation levels, the activity deriving from the magnetic resonance data and determined based on the order or timing of the functional magnetic resonance data;
outputting a graphical representation of dynamic activity in the brain corresponding to the delineated geometry of the anatomy, wherein the graphical representation of dynamic activity further comprises the sequence of activities and the sequence of activities; a step with propagation ;
How to have

2. The method of claim 1, wherein the graphical representation of dynamic activity comprises a brain activity map including at least one of said geometries.

2. The method of claim 1, further comprising associating at least one determined activation level and contoured geometry with a patient diagnosis.

2. The method of claim 1, wherein at least one of said activation levels comprises an average activation level.

5. The method of claim 4, wherein the average activation level comprises an event average activation level.

1. A system for obtaining activation data specific to anatomy within a patient's brain, comprising a computing device in communication with a magnetic resonance imaging device, said computing device comprising:
receiving magnetic resonance data of the brain obtained by use of a magnetic resonance imaging device, said magnetic resonance data comprising magnetic resonance data of anatomical structures within the patient's brain;
segmenting the brain magnetic resonance data to delineate a plurality of geometries, each of the plurality of geometries corresponding to a respective anatomical structure within the brain, the segmenting comprising: , based on a shape-constrained deformable 3D brain model, including adapting the 3D brain model to the anatomy within said brain;
receiving functional magnetic resonance data of the brain obtained by use of a magnetic resonance imaging device;
aligning the magnetic resonance data and the functional magnetic resonance data;
determining a plurality of activation levels based on the aligned magnetic resonance data and the functional magnetic resonance data, each of the plurality of activation levels corresponding to a respective delineated geometry; , step and
determining a sequence of activations of the anatomical structure based on the contoured geometry and corresponding activation levels, the sequence of activations comprising the magnetic resonance data and functional magnetic resonance data; a step determined based on the order or timing of
determining propagation of activity from one delineated geometry to another delineated geometry based on the delineated geometries and corresponding activation levels, the activity deriving from the magnetic resonance data and determined based on the order or timing of the functional magnetic resonance data;
outputting a graphical representation of dynamic activity in the brain corresponding to the delineated geometry of the anatomy;
a system operable to perform

7. The system of claim 6, further comprising at least one of said magnetic resonance imaging device and said database.

7. The system of claim 6, wherein the computing device is further operable to associate activation levels and sequences of activations within an anatomy with the patient's diagnosis of the brain.

wherein said computing device is further operable to store the activation level of each anatomical structure and the sequence of activation of said anatomical structure in a database along with said patient's diagnosis of said brain. Item 9. The system according to Item 8.