JPWO2020012175A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020012175A5 JPWO2020012175A5 JP2021500891A JP2021500891A JPWO2020012175A5 JP WO2020012175 A5 JPWO2020012175 A5 JP WO2020012175A5 JP 2021500891 A JP2021500891 A JP 2021500891A JP 2021500891 A JP2021500891 A JP 2021500891A JP WO2020012175 A5 JPWO2020012175 A5 JP WO2020012175A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- skin
- acid
- composition according
- aging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 28
- 210000003491 Skin Anatomy 0.000 claims 20
- -1 alprostadir Chemical compound 0.000 claims 16
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 10
- 210000004027 cells Anatomy 0.000 claims 8
- 230000002708 enhancing Effects 0.000 claims 7
- 108009000578 Oxidative Stress Proteins 0.000 claims 6
- 230000032683 aging Effects 0.000 claims 6
- 230000036542 oxidative stress Effects 0.000 claims 6
- 231100000277 DNA damage Toxicity 0.000 claims 5
- 230000033616 DNA repair Effects 0.000 claims 5
- 208000005679 Eczema Diseases 0.000 claims 5
- 201000004624 dermatitis Diseases 0.000 claims 5
- 231100001003 eczema Toxicity 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 201000011486 lichen planus Diseases 0.000 claims 5
- 230000004065 mitochondrial dysfunctions Effects 0.000 claims 5
- PVNIIMVLHYAWGP-UHFFFAOYSA-N nicotinic acid Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 5
- 229960003512 nicotinic acid Drugs 0.000 claims 5
- KZNIFHPLKGYRTM-UHFFFAOYSA-N Apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims 4
- YCIMNLLNPGFGHC-UHFFFAOYSA-N Catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 4
- RTIXKCRFFJGDFG-UHFFFAOYSA-N Chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 claims 4
- ZIUSSTSXXLLKKK-HWUZOJPISA-N Curcumin Natural products C1=C(O)C(OC)=CC(\C=C\C(\O)=C/C(=O)/C=C/C=2C=C(OC)C(O)=CC=2)=C1 ZIUSSTSXXLLKKK-HWUZOJPISA-N 0.000 claims 4
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims 4
- PWAOOJDMFUQOKB-ZSMJKITDSA-N Ginsenoside Re Natural products O([C@](CC/C=C(\C)/C)(C)[C@@H]1[C@H]2[C@@H](O)C[C@H]3[C@](C)([C@]2(C)CC1)C[C@H](O[C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O2)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@H]1C(C)(C)[C@@H](O)CC[C@]31C)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 PWAOOJDMFUQOKB-ZSMJKITDSA-N 0.000 claims 4
- LBQIJVLKGVZRIW-ZDUSSCGKSA-N Glabridin Chemical compound C1([C@H]2CC3=CC=C4OC(C=CC4=C3OC2)(C)C)=CC=C(O)C=C1O LBQIJVLKGVZRIW-ZDUSSCGKSA-N 0.000 claims 4
- IYRMWMYZSQPJKC-UHFFFAOYSA-N Kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 claims 4
- IQPNAANSBPBGFQ-UHFFFAOYSA-N Luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 claims 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N Methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims 4
- JOUIQRNQJGXQDC-XKNYDFJKSA-N [(2S,3R,4S,5S)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate Chemical compound O1[C@@H](COP(O)([O-])=O)[C@H](O)[C@H](O)[C@H]1[N+]1=CC=CC(C(O)=O)=C1 JOUIQRNQJGXQDC-XKNYDFJKSA-N 0.000 claims 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N benzohydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 4
- 235000001968 nicotinic acid Nutrition 0.000 claims 4
- 239000011664 nicotinic acid Substances 0.000 claims 4
- 206010015150 Erythema Diseases 0.000 claims 3
- DAYLJWODMCOQEW-TURQNECASA-N NMN zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)([O-])=O)O2)O)=C1 DAYLJWODMCOQEW-TURQNECASA-N 0.000 claims 3
- IKGXIBQEEMLURG-BKUODXTLSA-N Rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims 3
- 229940081967 Rutin Drugs 0.000 claims 3
- 235000005152 nicotinamide Nutrition 0.000 claims 3
- 239000011570 nicotinamide Substances 0.000 claims 3
- 229960003966 nicotinamide Drugs 0.000 claims 3
- 229930002876 rutin Natural products 0.000 claims 3
- 235000005493 rutin Nutrition 0.000 claims 3
- 229960004555 rutoside Drugs 0.000 claims 3
- YKJYKKNCCRKFSL-RDBSUJKOSA-N (-)-anisomycin Chemical compound C1=CC(OC)=CC=C1C[C@@H]1[C@H](OC(C)=O)[C@@H](O)CN1 YKJYKKNCCRKFSL-RDBSUJKOSA-N 0.000 claims 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18β-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims 2
- MHKBMNACOMRIAW-UHFFFAOYSA-N 2,3-dinitrophenol Chemical compound OC1=CC=CC([N+]([O-])=O)=C1[N+]([O-])=O MHKBMNACOMRIAW-UHFFFAOYSA-N 0.000 claims 2
- PXGPLTODNUVGFL-YNNPMVKQSA-N 9α,11α-PGF2 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O PXGPLTODNUVGFL-YNNPMVKQSA-N 0.000 claims 2
- 235000007639 Anthemis cotula Nutrition 0.000 claims 2
- 229940117893 Apigenin Drugs 0.000 claims 2
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 244000187129 Bacopa monnieria Species 0.000 claims 2
- 235000015418 Bacopa monnieria Nutrition 0.000 claims 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N Catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims 2
- 229940100626 Catechin Drugs 0.000 claims 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims 2
- 229950001002 Cianidanol Drugs 0.000 claims 2
- 229940109262 Curcumin Drugs 0.000 claims 2
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 2
- 229960002852 Ellagic Acid Drugs 0.000 claims 2
- 229920002079 Ellagic acid Polymers 0.000 claims 2
- XHEFDIBZLJXQHF-UHFFFAOYSA-N Fisetin Chemical compound C=1C(O)=CC=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 XHEFDIBZLJXQHF-UHFFFAOYSA-N 0.000 claims 2
- 108010070792 GAT Proteins 0.000 claims 2
- 229940045109 Genistein Drugs 0.000 claims 2
- ZCOLJUOHXJRHDI-CMWLGVBASA-N Genistin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims 2
- LPLVUJXQOOQHMX-MYOOOWEVSA-N Glycyrrhizic acid Natural products O=C(O)[C@H]1[C@@H](O)[C@H](O)[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@H](C(=O)O)O2)[C@@H](O[C@@H]2C(C)(C)[C@H]3[C@@](C)([C@H]4C(=O)C=C5[C@](C)([C@]4(C)CC3)CC[C@]3(C)[C@H]5C[C@](C(=O)O)(C)CC3)CC2)O1 LPLVUJXQOOQHMX-MYOOOWEVSA-N 0.000 claims 2
- 239000004378 Glycyrrhizin Substances 0.000 claims 2
- 229940094952 Green Tea Extract Drugs 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- AGBQKNBQESQNJD-SSDOTTSWSA-N Lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims 2
- 240000006223 Matricaria chamomilla Species 0.000 claims 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims 2
- 229960003987 Melatonin Drugs 0.000 claims 2
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims 2
- 229940053207 Niacin Drugs 0.000 claims 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N Nicotinamide adenine dinucleotide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims 2
- 229950010131 PUROMYCIN Drugs 0.000 claims 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N PUROMYCIN Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 2
- 240000007643 Phytolacca americana Species 0.000 claims 2
- 235000009074 Phytolacca americana Nutrition 0.000 claims 2
- 208000006641 Skin Disease Diseases 0.000 claims 2
- 102100000139 TRAF3IP2 Human genes 0.000 claims 2
- 229960001727 Tretinoin Drugs 0.000 claims 2
- RTKIYFITIVXBLE-QEQCGCAPSA-N Trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 2
- 229960004799 Tryptophan Drugs 0.000 claims 2
- 229930003537 Vitamin B3 Natural products 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- 229940041603 Vitamin K 3 Drugs 0.000 claims 2
- QDLHCMPXEPAAMD-QAIWCSMKSA-N Wortmannin Chemical compound C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 claims 2
- 230000002730 additional Effects 0.000 claims 2
- 235000008714 apigenin Nutrition 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 2
- 235000005487 catechin Nutrition 0.000 claims 2
- 229930016253 catechin Natural products 0.000 claims 2
- 235000001544 chamomile Nutrition 0.000 claims 2
- 230000001684 chronic Effects 0.000 claims 2
- 235000015838 chrysin Nutrition 0.000 claims 2
- 229940043370 chrysin Drugs 0.000 claims 2
- 229960004729 colecalciferol Drugs 0.000 claims 2
- 235000012754 curcumin Nutrition 0.000 claims 2
- 239000004148 curcumin Substances 0.000 claims 2
- 229960001342 dinoprost Drugs 0.000 claims 2
- 235000004132 ellagic acid Nutrition 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 235000006539 genistein Nutrition 0.000 claims 2
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims 2
- 229940093767 glabridin Drugs 0.000 claims 2
- 229960004949 glycyrrhizic acid Drugs 0.000 claims 2
- 235000019410 glycyrrhizin Nutrition 0.000 claims 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims 2
- 235000020688 green tea extract Nutrition 0.000 claims 2
- 235000008777 kaempferol Nutrition 0.000 claims 2
- 235000019136 lipoic acid Nutrition 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 235000009498 luteolin Nutrition 0.000 claims 2
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims 2
- 229960005201 menadione Drugs 0.000 claims 2
- 229960001047 methyl salicylate Drugs 0.000 claims 2
- 230000000116 mitigating Effects 0.000 claims 2
- 239000003226 mitogen Substances 0.000 claims 2
- 229950006238 nadide Drugs 0.000 claims 2
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 2
- 239000011618 nicotinamide riboside Substances 0.000 claims 2
- 229930002330 retinoic acid Natural products 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 230000036561 sun exposure Effects 0.000 claims 2
- 229960002663 thioctic acid Drugs 0.000 claims 2
- 235000019160 vitamin B3 Nutrition 0.000 claims 2
- 239000011708 vitamin B3 Substances 0.000 claims 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 2
- 229940021056 vitamin D3 Drugs 0.000 claims 2
- 235000005282 vitamin D3 Nutrition 0.000 claims 2
- 239000011647 vitamin D3 Substances 0.000 claims 2
- 235000012711 vitamin K3 Nutrition 0.000 claims 2
- 239000011652 vitamin K3 Substances 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- MPDGHEJMBKOTSU-PMTKVOBESA-N β-Glycyrrhetinic acid Chemical compound C([C@@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-PMTKVOBESA-N 0.000 claims 2
- BWVDQVQUNNBTLK-UHFFFAOYSA-N 1-methylpyridin-1-ium-3-carboximidate;hydrochloride Chemical compound [Cl-].C[N+]1=CC=CC(C(N)=O)=C1 BWVDQVQUNNBTLK-UHFFFAOYSA-N 0.000 claims 1
- 206010000496 Acne Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 208000010247 Contact Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010014970 Ephelide Diseases 0.000 claims 1
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000001126 Keratosis Diseases 0.000 claims 1
- GDNIGMNXEKGFIP-UHFFFAOYSA-O Luteolinidin Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=CC=1C1=CC=C(O)C(O)=C1 GDNIGMNXEKGFIP-UHFFFAOYSA-O 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 1
- 206010049752 Peau d'orange Diseases 0.000 claims 1
- 206010034972 Photosensitivity reaction Diseases 0.000 claims 1
- 206010062080 Pigmentation disease Diseases 0.000 claims 1
- 229960001285 Quercetin Drugs 0.000 claims 1
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 1
- 206010037844 Rash Diseases 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N Retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000008742 Seborrheic Dermatitis Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 206010039796 Seborrhoeic keratosis Diseases 0.000 claims 1
- 210000002374 Sebum Anatomy 0.000 claims 1
- 206010040799 Skin atrophy Diseases 0.000 claims 1
- 206010040925 Skin striae Diseases 0.000 claims 1
- 206010041823 Squamous cell carcinoma Diseases 0.000 claims 1
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 claims 1
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 claims 1
- 206010042496 Sunburn Diseases 0.000 claims 1
- 206010044223 Toxic epidermal necrolysis Diseases 0.000 claims 1
- 231100000087 Toxic epidermal necrolysis Toxicity 0.000 claims 1
- SHGAZHPCJJPHSC-NWVFGJFESA-N Tretinoin Chemical compound OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NWVFGJFESA-N 0.000 claims 1
- DBRXOUCRJQVYJQ-CKNDUULBSA-N Withaferin A Chemical compound C([C@@H]1[C@H]([C@@H]2[C@]3(CC[C@@H]4[C@@]5(C)C(=O)C=C[C@H](O)[C@@]65O[C@@H]6C[C@H]4[C@@H]3CC2)C)C)C(C)=C(CO)C(=O)O1 DBRXOUCRJQVYJQ-CKNDUULBSA-N 0.000 claims 1
- DBRXOUCRJQVYJQ-NHEHKMGMSA-N Withaferin A Natural products O=C1C(CO)=C(C)C[C@H]([C@H](C)[C@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@@]5(C)C(=O)C=C[C@H](O)[C@@]65O[C@@H]6C4)CC3)CC2)O1 DBRXOUCRJQVYJQ-NHEHKMGMSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 230000036232 cellulite Effects 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 231100000080 dermatitis contact Toxicity 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 235000011990 fisetin Nutrition 0.000 claims 1
- 230000005484 gravity Effects 0.000 claims 1
- 230000002757 inflammatory Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229930013978 luteolinidin Natural products 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000036211 photosensitivity Effects 0.000 claims 1
- 230000019612 pigmentation Effects 0.000 claims 1
- UQOQENZZLBSFKO-POPPZSFYSA-N prostaglandin J2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O UQOQENZZLBSFKO-POPPZSFYSA-N 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 235000005875 quercetin Nutrition 0.000 claims 1
- 229930002344 quercetin Natural products 0.000 claims 1
- 238000007665 sagging Methods 0.000 claims 1
- 201000003385 seborrheic keratosis Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000037394 skin elasticity Effects 0.000 claims 1
- 230000000391 smoking Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000002522 swelling Effects 0.000 claims 1
- 230000002087 whitening Effects 0.000 claims 1
- 200000000019 wound Diseases 0.000 claims 1
- AXFYFNCPONWUHW-UHFFFAOYSA-N β-Hydroxy β-methylbutyric acid Chemical compound CC(C)(O)CC(O)=O AXFYFNCPONWUHW-UHFFFAOYSA-N 0.000 claims 1
Claims (20)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1811312.6 | 2018-07-10 | ||
| GBGB1811312.6A GB201811312D0 (en) | 2018-07-10 | 2018-07-10 | Compositions |
| PCT/GB2019/051931 WO2020012175A1 (en) | 2018-07-10 | 2019-07-10 | Compositions that protect cells from oxidative and mitochondrial stress |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021524495A JP2021524495A (en) | 2021-09-13 |
| JPWO2020012175A5 true JPWO2020012175A5 (en) | 2022-07-15 |
Family
ID=63273195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500891A Pending JP2021524495A (en) | 2018-07-10 | 2019-07-10 | A composition that protects cells from oxidative and mitochondrial stress |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210267870A1 (en) |
| EP (1) | EP3820433A1 (en) |
| JP (1) | JP2021524495A (en) |
| KR (1) | KR20210031706A (en) |
| CN (1) | CN112423726A (en) |
| AU (1) | AU2019300315A1 (en) |
| CA (1) | CA3104982A1 (en) |
| GB (2) | GB201811312D0 (en) |
| WO (1) | WO2020012175A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021155341A1 (en) * | 2020-02-01 | 2021-08-05 | Ageless Sciences, Inc. | Compositions and methods for treating aging-related disorders |
| CN111096972B (en) * | 2020-02-25 | 2023-07-14 | 成都医学院 | Pharmaceutical composition for preventing and/or treating Alzheimer's disease |
| CN111333662A (en) * | 2020-04-09 | 2020-06-26 | 西南医科大学 | 3,4' -O-dimethyl gallic acid, its derivative and pharmaceutical use thereof |
| BR112022023637A2 (en) * | 2020-06-19 | 2022-12-20 | Hofleitner Peter | COMPOSITION, AND METHOD FOR PREVENTING OR TREATMENT OF A VIRAL INFECTION |
| JP2022024400A (en) * | 2020-07-28 | 2022-02-09 | エリジオンサイエンス株式会社 | Hair restorer/grower |
| CN111939154A (en) * | 2020-08-24 | 2020-11-17 | 周琛 | Anti-aging composition, application thereof, and health food and medicine containing anti-aging composition |
| KR102428120B1 (en) * | 2020-09-23 | 2022-08-04 | 주식회사 티에스바이오 | A novel composition for stem cell culture |
| EP4199930A4 (en) * | 2020-10-21 | 2024-01-24 | Nanjing Nutrabuilding Bio-Tech Co., Ltd. | Methods for improving exercise performance and endurance thereof |
| CN112451673A (en) * | 2020-12-10 | 2021-03-09 | 汤臣倍健股份有限公司 | Application of mitochondrial function intervention material in preparation of health-care product or medicine for improving mitochondrial function and screening method thereof |
| CN113181205B (en) * | 2021-04-19 | 2023-07-14 | 苏州人本药业有限公司 | Pharmaceutical composition comprising NMN and use thereof |
| WO2023008615A1 (en) * | 2021-07-29 | 2023-02-02 | 바이오스펙트럼 주식회사 | Composition for inhibiting sebum secretion comprising ellagic acid as active ingredient |
| CN113459697B (en) * | 2021-08-10 | 2022-10-11 | 中山市富日印刷材料有限公司 | Anti-calcification alcohol-free fountain solution and preparation method thereof |
| CN116019780B (en) * | 2021-10-26 | 2024-09-24 | 成都拂尔医药科技有限公司 | Double-yellow nano-particles and preparation and application thereof |
| PL440896A1 (en) | 2022-04-11 | 2023-10-16 | Uniwersytet Gdański | Genistein for use in preventing the loss of memory and cognitive abilities in healthy people as a result of the gradual physiological aging processes of the brain with age, as a factor preventing and reducing the deposition of harmful insoluble protein aggregates and deposits in the brain, in particular beta-amyloid |
| RS20220433A1 (en) | 2022-05-11 | 2023-11-30 | Milan Prokin | Multitarget antiviral dietary supplement |
| WO2024050820A1 (en) * | 2022-09-09 | 2024-03-14 | 深圳华大智造科技股份有限公司 | Antioxidant composition and use thereof in nucleic acid detection |
| CN116672352B (en) * | 2023-06-26 | 2024-04-19 | 珍卡儿药妆有限公司 | Pharmaceutical composition for eczema and application thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU83173A1 (en) | 1981-02-27 | 1981-06-05 | Oreal | NOVEL COSMETIC COMPOSITIONS FOR THE TREATMENT OF HAIR AND SKIN CONTAINING POWDER RESULTING FROM THE SPRAYING OF AT LEAST ONE PLANT AND A COHESION AGENT |
| US4677120A (en) | 1985-07-31 | 1987-06-30 | Molecular Design International | Topical prodrugs for treatment of acne and skin diseases |
| US5124356A (en) | 1987-06-29 | 1992-06-23 | Molecular Design International, Inc. | Dermal uses of trans-retinoids for the treatment of photoaging |
| US4885311A (en) | 1987-06-29 | 1989-12-05 | Molecular Design International | Topical transretinoids for treatment of acne and skin diseases |
| US5049584A (en) | 1988-12-14 | 1991-09-17 | Molecular Design International | Dermal uses of cis-retinoids for the treatment of cancer |
| US5139771A (en) | 1990-04-16 | 1992-08-18 | Revlon, Inc. | Rinse away face masque |
| CA2204777A1 (en) * | 1994-11-15 | 1996-05-23 | Steven Scott Porter | Skin care compositions and methods |
| US5648389A (en) * | 1995-10-27 | 1997-07-15 | Medicis Pharmaceutical, Inc. | Compositions for the treatment of dermatological disorders and methods for their use |
| JPH107541A (en) * | 1996-06-20 | 1998-01-13 | Noevir Co Ltd | Skin lotion |
| FR2758083B1 (en) | 1997-01-03 | 1999-02-05 | Oreal | COSMETIC AND / OR DERMATOLOGICAL COMPOSITION CONTAINING A DISPERSION OF A POLYMERIC SYSTEM AND USE OF THE SYSTEM AS A TENSIONER |
| US6299889B1 (en) * | 1998-09-10 | 2001-10-09 | Avon Products, Inc. | Stable ascorbic acid preparation for topical use |
| FR2811550B1 (en) * | 2000-07-11 | 2003-02-14 | Oreal | COMPOSITION BASED ON VITAMINS AND MINERAL SALTS, FOR REDUCING HAIR LOSS AND / OR PROMOTING HAIR GROWTH |
| AU2002221934A1 (en) * | 2000-12-16 | 2002-06-24 | Aventis Pharma Deutschland Gmbh | Health promoting compositions |
| US6660293B2 (en) * | 2001-06-29 | 2003-12-09 | Everett Laboratories, Inc. | Compositions and methods for prophylactic and therapeutic supplementation of nutrition in subjects |
| EP1429750B1 (en) * | 2001-09-06 | 2010-08-04 | Synorx, Inc. | Inhibition by 3-deoxyflavonoids of t-lymphocyte activation and therapies related thereto |
| US20030194453A1 (en) * | 2002-04-15 | 2003-10-16 | Coleman Henry D. | Dietary supplement |
| MXPA05002512A (en) * | 2002-09-06 | 2005-08-16 | Drysdale Kenneth William Patte | Apparatus, method and software for use with an air conditioning cycle. |
| JP2004131500A (en) * | 2002-09-19 | 2004-04-30 | Fancl Corp | Skin aging inhibitor or improver |
| US7108869B2 (en) * | 2002-11-07 | 2006-09-19 | Access Business Group International Llc | Nutritional supplement containing alpha-glucosidase and alpha-amylase inhibitors |
| JP2004189645A (en) * | 2002-12-10 | 2004-07-08 | Kanebo Ltd | Cosmetic |
| JP2005220084A (en) * | 2004-02-06 | 2005-08-18 | Kose Corp | Acerola seed extract-containing composition |
| US20050287227A1 (en) * | 2004-04-16 | 2005-12-29 | Ronald Pero | Supplement containing carotenoid, nicotinamide, zinc, water soluble extract of uncaria species and method of the same |
| CN101084003A (en) * | 2004-12-21 | 2007-12-05 | 重症救护联络公司 | Therapeutic nutrient compositions or combinations and methods of their use |
| US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
| US20060269616A1 (en) * | 2005-05-26 | 2006-11-30 | Suracell, Inc. | Supplement composition and method of use for enhancement of DNA repair process |
| CA2524990A1 (en) * | 2005-10-31 | 2007-04-30 | Scienta Health, Inc. | Oral skin supplement |
| WO2007148832A1 (en) * | 2006-06-23 | 2007-12-27 | Ajinomoto Co., Inc. | Skin whitening agent containing zinc as active ingredient |
| EP2040708B1 (en) * | 2006-07-17 | 2018-03-14 | Thomas Christian Lines | Quercetin-containing compositions |
| EP2113242A1 (en) * | 2008-05-02 | 2009-11-04 | Pangaea Laboratories Limited | Antioxidant for use in cosmetic, medicated and pharmaceutical preparations |
| JP2010163363A (en) * | 2009-01-13 | 2010-07-29 | Kao Corp | Method for producing extract containing apigenin in high concentration |
| GB0905864D0 (en) * | 2009-04-03 | 2009-05-20 | Glaxo Group Ltd | Novel use |
| CA3023725C (en) * | 2009-10-22 | 2021-09-14 | Vizuri Health Sciences Llc | Methods of producing hydrated flavonoids and use thereof in the preparation of topical compositions |
| DE102011105703A1 (en) * | 2011-06-22 | 2012-12-27 | Wolfgang Langhoff | Dietetics for the treatment of mitochondrial dysfunctions |
| WO2012178014A1 (en) * | 2011-06-24 | 2012-12-27 | K-Pax Pharmaceuticals, Inc. | Compositions and methods for treatment of chronic fatigue |
| US20130129680A1 (en) * | 2011-11-23 | 2013-05-23 | Thomas Christian Lines | Method for treating hepatitis c virus infection using quercetin-containing compositions |
| EP2786741B1 (en) * | 2011-11-30 | 2018-12-26 | Ajinomoto Co., Inc. | Whitening cosmetic |
| US20140348966A1 (en) * | 2011-12-22 | 2014-11-27 | Onesmo B. Balemba | Garcinia buchananii baker compounds, compositions and related methods |
| US9745279B2 (en) * | 2011-12-27 | 2017-08-29 | Tokiwa Phytochemical Co., Ltd. | Sirtuin activator |
| WO2014022886A1 (en) * | 2012-08-08 | 2014-02-13 | Fischer Karen Jane | A method, use, and dietary supplement composition for at least treating an atopic or non-atopic disorder in a patient |
| JP6329757B2 (en) * | 2012-12-04 | 2018-05-23 | ロート製薬株式会社 | Composition for external use |
| EP2789369B1 (en) * | 2013-04-14 | 2018-06-06 | Symrise AG | A composition for lightening skin and hair |
| AU2016274126A1 (en) * | 2015-06-10 | 2018-01-18 | Elysium Health, Inc. | Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders |
| CN108882743B (en) * | 2016-03-29 | 2022-11-11 | 捷通国际有限公司 | Nutritional supplements for activating the antioxidant system of a subject and related methods |
| KR20170119757A (en) * | 2016-04-19 | 2017-10-30 | 김순관 | Apigenin cosmetic composition using the amino acid and germanium |
-
2018
- 2018-07-10 GB GBGB1811312.6A patent/GB201811312D0/en not_active Ceased
-
2019
- 2019-07-10 CN CN201980046536.8A patent/CN112423726A/en active Pending
- 2019-07-10 KR KR1020217002951A patent/KR20210031706A/en active Search and Examination
- 2019-07-10 JP JP2021500891A patent/JP2021524495A/en active Pending
- 2019-07-10 WO PCT/GB2019/051931 patent/WO2020012175A1/en unknown
- 2019-07-10 EP EP19759673.7A patent/EP3820433A1/en active Pending
- 2019-07-10 GB GB2101405.5A patent/GB2590020A/en not_active Withdrawn
- 2019-07-10 CA CA3104982A patent/CA3104982A1/en active Pending
- 2019-07-10 AU AU2019300315A patent/AU2019300315A1/en active Pending
- 2019-07-10 US US17/258,258 patent/US20210267870A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2020012175A5 (en) | ||
| GB2590020A (en) | Compositions that protect cells from oxidative and mitochondrial stress | |
| Jiménez-Pérez et al. | Applications of Panax ginseng leaves-mediated gold nanoparticles in cosmetics relation to antioxidant, moisture retention, and whitening effect on B16BL6 cells | |
| Lee et al. | Protective effect of Codium fragile against UVB-induced pro-inflammatory and oxidative damages in HaCaT cells and BALB/c mice | |
| Casarini et al. | Dermatological applications of the flavonoid phloretin | |
| Patricia Farris et al. | Resveratrol: A unique antioxidant offering a multi-mechanistic approach for treating aging skin | |
| JP2021515796A (en) | Composition | |
| RU2017145692A (en) | COMPOSITIONS OF NICOTINAMIDE RIBOSIDE AND PTEROSTYLBENE AND METHODS OF TREATING DISEASES OF THE SKIN | |
| Mustapha et al. | Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis | |
| Cheng et al. | Honokiol: A naturally occurring lignan with pleiotropic bioactivities | |
| US9511013B2 (en) | Herbal composition for skin-whitening and anti-skin-aging, method of preparation and the use thereof | |
| JP2008540513A5 (en) | ||
| US20100291190A1 (en) | Topical Composition For Anti-Aging Skin Treatment Using Dual DNA Repair Mechanism and Method of Use | |
| Choi et al. | Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract | |
| Baumann | How to prevent photoaging? | |
| KR20230021049A (en) | Composition for improving skin conditions comprising Ethyl ferulate | |
| US20140004210A1 (en) | Degradation inhibitor of hyaluronic acid, comprising rosemary extract and retinol acetate | |
| Li et al. | Bioactivity and application of anthocyanins in skin protection and cosmetics: an extension as a functional pigment | |
| US20060281793A1 (en) | Pharmaceutical composition for the management of tumors | |
| KR20130005616A (en) | Skin whitening agent | |
| KR20140008364A (en) | Bakuchiol compositions for treatment of post inflammatory hyperpigmentation | |
| US20130202540A1 (en) | Method for repair of acute and chronic injury, such as burned and photodamaged skin | |
| KR100639408B1 (en) | Cosmetic composition comprising the extract of Bambusae Folium showing inhibitory effect and whitening effect on UV-induced skin damage | |
| Ellermann et al. | Divergent antiarrhythmic effects of resveratrol and piceatannol in a whole-heart model of long QT syndrome | |
| RU2007121769A (en) | COSMETIC COMPOSITION CONTAINING EXTRACT LIMNOCITRUS LITTORALIS |