JPWO2019234164A5 - - Google Patents

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JPWO2019234164A5
JPWO2019234164A5 JP2020567847A JP2020567847A JPWO2019234164A5 JP WO2019234164 A5 JPWO2019234164 A5 JP WO2019234164A5 JP 2020567847 A JP2020567847 A JP 2020567847A JP 2020567847 A JP2020567847 A JP 2020567847A JP WO2019234164 A5 JPWO2019234164 A5 JP WO2019234164A5
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pulse
assist system
pulse doppler
doppler measurement
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移植された血管補助システム（１）を流れる流体の流量ｖを決定する方法であって、前記方法は、
前記血管補助システム（１）の超音波センサ（２）によって、第一のパルス繰返し速度ＰＲＦ １ で第一のパルスドップラー測定を実行する工程ａ）と、
前記血管補助システム（１）の前記超音波センサ（２）によって、第二のパルス繰返し速度ＰＲＦ ２ ＞ＰＲＦ １ で第二のパルスドップラー測定を実行する工程であって、前記第二のパルス繰返し速度は前記第一のパルス繰返し速度とは異なる、工程ｂ）と、
整数ｎ １ 、ｎ ２ および前記第一のパルスドップラー測定の主周波数成分ｆ １ および前記第二のパルスドップラー測定の主周波数成分ｆ ２ を解くことにより、前記第一のパルスドップラー測定および前記第二のパルスドップラー測定の測定結果を使用して前記流量を決定することであって、以下の線形ディオファントス方程式を使用して決定する工程ｃ）とを含むことにより特徴付けられる、方法：
Figure 2019234164000001
 境界条件
Figure 2019234164000002
 以下と仮定：
Figure 2019234164000003
 式中、
Figure 2019234164000004
 および式中、ｆ ０ は、前記超音波センサ（２）の超音波透過周波数であり、ｃ ０ は、前記流体中の音速である。 A method of determining the flow rate v of the fluid flowing through the transplanted vascular assist system (1), wherein the method is:
Step a) of performing the first pulse Doppler measurement at the first pulse repetition frequency PRF 1 by the ultrasonic sensor (2) of the blood vessel assist system (1).
A step of performing a second pulse Doppler measurement with a second pulse repetition frequency PRF 2 > PRF 1 by the ultrasonic sensor (2) of the vascular assist system (1), wherein the second pulse repetition rate Is different from the first pulse repetition rate, step b) and
The first pulse Doppler measurement and the second by solving the integers n 1 , n 2 and the main frequency component f 1 of the first pulse Doppler measurement and the main frequency component f 2 of the second pulse Doppler measurement. The method of determining the flow rate using the measurement results of the pulse Doppler measurement of the above, characterized by including step c) and determination using the following linear Diophantos equation :
Figure 2019234164000001
 boundary condition
Figure 2019234164000002
 Assuming:
Figure 2019234164000003
 During the ceremony
Figure 2019234164000004
 And in the equation , f 0 is the ultrasonic transmission frequency of the ultrasonic sensor (2), and c 0 is the speed of sound in the fluid . 前記二つの工程ａ）およびｂ）のうちの少なくとも一つにおいて、新しい超音波パルスが、直前に発信された該超音波パルスのエコーが受信された後にのみ発信されることにより特徴付けられる、請求項１に記載の方法。 Claimed that in at least one of the two steps a) and b), a new ultrasonic pulse is emitted only after the echo of the ultrasonic pulse emitted immediately before is received. Item 1. The method according to Item 1. ＰＲＦ １ またはＰＲＦ ２ は、最大発生ドップラーシフトの二倍未満であることにより特徴付けられる、請求項１または２に記載の方法。 The method of claim 1 or 2, wherein PRF 1 or PRF 2 is characterized by being less than twice the maximum Doppler shift. 前記工程ｃ）において、前記パルスドップラー測定のドップラー周波数スペクトル（４）の検出された主周波数成分（１４）と、前記パルスドップラー測定に適用される前記パルス繰返し速度との間の相関が使用されることにより特徴付けられる、請求項１～３のいずれか一項に記載の方法。 In step c), the correlation between the detected principal frequency component (14) of the Doppler frequency spectrum (4) of the pulse Doppler measurement and the pulse repetition rate applied to the pulse Doppler measurement is used. The method according to any one of claims 1 to 3, which is characterized by the above. 前記線形ディオファントス方程式は、ベズー係数または取り尽くし法を使用して求解されることにより特徴付けられる、請求項１～４のいずれか一項に記載の方法。 The method according to any one of claims 1 to 4, wherein the linear Diophantine equation is characterized by being solved using Bezout's coefficient or exhaustion method. 請求項１～５のいずれか一項に記載の方法で決定することにより移植された血管補助システム（１）を通る流体、前記血管補助システムにおける前記流体の前記流量ｖおよびそこから前記血管補助システム（１）を通る流体体積流を決定する方法。 The fluid passing through the vascular assist system (1) transplanted by the method according to any one of claims 1 to 5, the flow rate v of the fluid in the vascular assist system, and the vascular assist system from there. A method for determining a fluid volume flow through (1). 超音波センサ（２）を備え、処理ユニット（３）を備える移植可能な血管補助システム（１）であって、
前記超音波センサ（２）は、異なるパルス繰返し速度ＰＲＦ １ ＜ＰＲＦ ２ でパルスドップラー測定を実行するように設計されることと、
前記処理ユニット（３）は、前記異なるパルス繰返し速度での前記パルスドップラー測定の測定結果を使用して、前記血管補助システム（１）を流れる流体の流量を決定するように設計されることとにより特徴付けられ、
前記第一のパルスドップラー測定および前記第二のパルスドップラー測定の測定結果を使用して前記流量を決定することは、前記第一のパルスドップラー測定の整数ｎ １ 、ｎ ２ および主周波数成分ｆ １ 、および前記第二のパルスドップラー測定の主周波数成分ｆ ２ を解くことによって以下の線形ディオファントス方程式によって実行される、移植可能な血管補助システム：
Figure 2019234164000005
 境界条件
Figure 2019234164000006
 以下と仮定：
Figure 2019234164000007
 式中、
Figure 2019234164000008
 および式中、ｆ ０ は、前記超音波センサ（２）の超音波透過周波数であり、ｃ ０ は、前記流体中の音速である。 An implantable vascular assist system (1) equipped with an ultrasonic sensor (2) and a processing unit (3) .
The ultrasonic sensor (2) is designed to perform pulse Doppler measurements at different pulse repetition frequencies PRF 1 <PRF 2 .
The processing unit (3) is designed to determine the flow rate of fluid flowing through the vascular assist system (1) using the measurement results of the pulse Doppler measurements at the different pulse repetition rates. Characterized,
Determining the flow rate using the measurement results of the first pulse Doppler measurement and the second pulse Doppler measurement is the integers n 1 , n 2 and the main frequency component f 1 of the first pulse Doppler measurement. , And the implantable vascular assist system performed by the following linear Diophanths equation by solving the main frequency component f 2 of the second pulse Doppler measurement :
Figure 2019234164000005
 boundary condition
Figure 2019234164000006
 Assuming:
Figure 2019234164000007
 During the ceremony
Figure 2019234164000008
 And in the equation , f 0 is the ultrasonic transmission frequency of the ultrasonic sensor (2), and c 0 is the speed of sound in the fluid . 前記線形ディオファントス方程式は、ベズー係数または取り尽くし法を使用して求解されることにより特徴付けられる、請求項７に記載の移植可能な血管補助システム。The implantable vascular assist system according to claim 7, wherein the linear Diophantine equation is characterized by being solved using Bezout's coefficient or exhaustion method. 前記処理ユニット（３）は、前記流量から計算された流体流を提供するように設計されることにより特徴付けられる、請求項７または８に記載の移植可能な血管補助システム。The implantable vascular assist system according to claim 7 or 8, wherein the processing unit (3) is characterized by being designed to provide a fluid flow calculated from the flow rate.
JP2020567847A 2018-06-06 2019-06-06 Methods for Determining Fluid Flow Rate through Implanted and Implantable Vascular Assist Systems Active JP7376109B2 (en)

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DE102018208929.9A DE102018208929A1 (en) 2018-06-06 2018-06-06 A method of determining a flow rate of fluid flowing through an implanted vascular support system
DE102018208929.9 2018-06-06
PCT/EP2019/064804 WO2019234164A1 (en) 2018-06-06 2019-06-06 Method for determining a flow rate of a fluid flowing through an implanted vascular support system, and implantable vascular support system

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WO2022109591A2 (en) 2020-11-20 2022-05-27 Kardion Gmbh Mechanical circulatory support system with insertion tool
US20230173250A1 (en) 2021-12-03 2023-06-08 Kardion Gmbh Cardiac pump with optical fiber for laser doppler
US20240011808A1 (en) 2022-07-11 2024-01-11 Kardion Gmbh Laser doppler velocimetry flow measurement

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