JPWO2019231271A5 - - Google Patents
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- Publication number
- JPWO2019231271A5 JPWO2019231271A5 JP2020566834A JP2020566834A JPWO2019231271A5 JP WO2019231271 A5 JPWO2019231271 A5 JP WO2019231271A5 JP 2020566834 A JP2020566834 A JP 2020566834A JP 2020566834 A JP2020566834 A JP 2020566834A JP WO2019231271 A5 JPWO2019231271 A5 JP WO2019231271A5
- Authority
- JP
- Japan
- Prior art keywords
- present
- activation
- novel heterocyclic
- stat3 protein
- suppresses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004495 STAT3 Transcription Factor Human genes 0.000 description 2
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 150000002391 heterocyclic compounds Chemical class 0.000 description 2
- 102000000887 Transcription factor STAT Human genes 0.000 description 1
- 108050007918 Transcription factor STAT Proteins 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Description
本発明は、新規複素環化合物、ＳＴＡＴタンパク質、特に、ＳＴＡＴ３タンパク質活性化に関連する疾患を予防又は治療するためのその使用及びそれを含む医薬組成物に関するものである。 The present invention relates to novel heterocyclic compounds , STAT proteins, in particular their use for the prevention or treatment of diseases associated with STAT3 protein activation and pharmaceutical compositions containing them.
したがって、本発明の目的は、ＳＴＡＴ３タンパク質の活性化を抑制する新規の複素環化合物を提供することである。
Therefore, it is an object of the present invention to provide a novel heterocyclic compound that suppresses the activation of the STAT3 protein.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20180062450 | 2018-05-31 | ||
| KR10-2018-0062450 | 2018-05-31 | ||
| PCT/KR2019/006554 WO2019231271A1 (en) | 2018-05-31 | 2019-05-31 | Heterocyclic derivatives and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021525752A JP2021525752A (en) | 2021-09-27 |
| JPWO2019231271A5 true JPWO2019231271A5 (en) | 2022-03-31 |
| JP7558066B2 JP7558066B2 (en) | 2024-09-30 |
Family
ID=68698337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020566834A Active JP7558066B2 (en) | 2018-05-31 | 2019-05-31 | Heterocyclic derivatives and their uses |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210155594A1 (en) |
| EP (1) | EP3802495A4 (en) |
| JP (1) | JP7558066B2 (en) |
| KR (1) | KR102229471B1 (en) |
| CN (1) | CN112204010B (en) |
| WO (1) | WO2019231271A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110105237B (en) * | 2019-06-06 | 2021-12-24 | 东北师范大学 | Beta-gem-difluoro azide compound and preparation and application thereof |
| WO2022187411A1 (en) * | 2021-03-02 | 2022-09-09 | Kumquat Biosciences Inc. | Heterocycles and uses thereof |
| CN113845476B (en) * | 2021-11-08 | 2024-04-30 | 中国药科大学 | Quinolone derivative and preparation method and application thereof |
| CN114315802B (en) * | 2021-12-14 | 2023-06-16 | 西安医学院 | Quinazoline nitrogen-containing heterocyclic derivative, preparation method and application |
| AU2023255692A1 (en) | 2022-04-20 | 2024-10-03 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
| EP4296674A1 (en) | 2022-06-20 | 2023-12-27 | Université Toulouse III - Paul Sabatier | Innovative molecules decreasing virulence of mycobacterium for the treatment of tuberculosis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR960007566A (en) | 1994-08-19 | 1996-03-22 | 김정규 | Novel quinolylamine derivatives, methods for their preparation and use as antiarrhythmics |
| AU4878601A (en) | 2000-04-20 | 2001-11-07 | Mitsubishi Corporation | Aromatic amide compounds |
| WO2005061516A1 (en) * | 2003-12-04 | 2005-07-07 | Smithkline Beecham Corporation | Novel chemical compounds |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| US20060074105A1 (en) * | 2004-09-20 | 2006-04-06 | Serenex, Inc. | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 |
| WO2007013964A1 (en) | 2005-07-22 | 2007-02-01 | Sunesis Pharmaceuticals, Inc. | Pyrazolo pyrimidines useful as aurora kinase inhibitors |
| US20090170847A1 (en) | 2006-01-23 | 2009-07-02 | Seung Chul Lee | Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same |
| WO2008086462A2 (en) | 2007-01-11 | 2008-07-17 | Wyeth | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS |
| EP2014663A1 (en) * | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma AG | Thieno-pyrimidyl amines as modulators of EP2 receptors |
| DE102007032739A1 (en) | 2007-07-13 | 2009-01-15 | Merck Patent Gmbh | Chinazolinamidderivate |
| US8735584B2 (en) | 2008-02-28 | 2014-05-27 | Merck Patent Gmbh | Protein kinase inhibitors and use thereof |
| NZ590355A (en) | 2008-07-10 | 2013-01-25 | Yakult Honsha Kk | Stat3 inhibitor containing quinolinecarboxamide derivative as active ingredient |
| CN102232071B (en) | 2008-09-26 | 2016-03-23 | 财团法人卫生研究院 | As the fused-polycyclic compounds of kinases inhibitor |
| CA2737472A1 (en) | 2008-09-26 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Azaindazole compounds as ccr1 receptor antagonists |
| AU2010214095B2 (en) | 2009-02-11 | 2015-12-24 | Merck Patent Gmbh | Novel amino azaheterocyclic carboxamides |
| WO2012079079A1 (en) * | 2010-12-10 | 2012-06-14 | President And Fellows Of Harvard College | Production of induced pluripotent stem cells |
| WO2014145512A2 (en) | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Potent small molecule inhibitors of autophagy, and methods of use thereof |
| BR112020004209A2 (en) * | 2017-08-31 | 2020-09-01 | Abbvie Inc. | ectonucleotide piophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and their use |
-
2019
- 2019-05-31 WO PCT/KR2019/006554 patent/WO2019231271A1/en unknown
- 2019-05-31 KR KR1020190064288A patent/KR102229471B1/en active IP Right Grant
- 2019-05-31 US US17/058,209 patent/US20210155594A1/en active Pending
- 2019-05-31 JP JP2020566834A patent/JP7558066B2/en active Active
- 2019-05-31 EP EP19812552.8A patent/EP3802495A4/en active Pending
- 2019-05-31 CN CN201980035635.6A patent/CN112204010B/en active Active
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