JPWO2019195196A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2019195196A5
JPWO2019195196A5 JP2020554865A JP2020554865A JPWO2019195196A5 JP WO2019195196 A5 JPWO2019195196 A5 JP WO2019195196A5 JP 2020554865 A JP2020554865 A JP 2020554865A JP 2020554865 A JP2020554865 A JP 2020554865A JP WO2019195196 A5 JPWO2019195196 A5 JP WO2019195196A5
Authority
JP
Japan
Prior art keywords
dielectric material
silicon
dielectric
layer
metalloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020554865A
Other languages
Japanese (ja)
Other versions
JP2021520218A (en
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/025242 external-priority patent/WO2019195196A1/en
Publication of JP2021520218A publication Critical patent/JP2021520218A/en
Publication of JPWO2019195196A5 publication Critical patent/JPWO2019195196A5/ja
Priority to JP2023213223A priority Critical patent/JP2024037944A/en
Pending legal-status Critical Current

Links

Claims (20)

分析物を捕捉するためのデバイスであって、A device for capturing analytes
a)動電場領域を生成するように構成された電極、および a) Electrodes configured to generate an electrokinetic field region, and
b)前記電極の少なくとも一部分と接触している層であって、誘電体材料を含み、厚さが100オングストローム未満である層 b) A layer in contact with at least a portion of the electrode, containing a dielectric material and having a thickness of less than 100 angstroms.
を含む、デバイス。Including devices.
前記動電場が誘電場、電熱場、電気浸透場、またはそれらの組み合わせを含む、請求項1に記載のデバイス。The device according to claim 1, wherein the electrokinetic field includes a dielectric field, an electric heating field, an electroosmotic field, or a combination thereof. 前記層が約5オングストローム-約25オングストロームの厚さである、請求項1または2に記載のデバイス。The device of claim 1 or 2, wherein the layer is about 5 angstroms-about 25 angstroms thick. 前記層が50オングストローム以下の厚さである、請求項1または2に記載のデバイス。The device of claim 1 or 2, wherein the layer is 50 angstroms or less in thickness. 前記誘電体材料が、メタロイド酸化物、メタロイド窒化物、メタロイドカーバイド、メタロイドケイ化物、またはそれらの組み合わせを含む、請求項1-4のいずれか1項に記載のデバイス。The device according to any one of claims 1-4, wherein the dielectric material comprises a metalloid oxide, a metalloid nitride, a metalloid carbide, a metalloid silicide, or a combination thereof. 前記メタロイドが、ホウ素、シリコン、ゲルマニウム、ヒ素、アンチモン、テルル、およびそれらの組み合わせからなる群から選択される、請求項5に記載のデバイス。The device of claim 5, wherein the metalloid is selected from the group consisting of boron, silicon, germanium, arsenic, antimony, telluride, and combinations thereof. 前記誘電体材料が金属をさらに含む、請求項1-6のいずれか1項に記載のデバイス。The device according to any one of claims 1-6, wherein the dielectric material further comprises a metal. 前記金属が、白金、ルテニウム、ロジウム、イリジウム、マンガン、マグネシウム、タングステン、ジルコニウム、クロム、金、鉄、アルミニウム、タンタル、ガリウム、銅、銀、真ちゅう、亜鉛、スズ、ニッケル、パラジウム、チタン、コバルト、インジウム、ビスマス、鉛、ランタン、ハフニウム、イットリウム、カルシウム、ストロンチウム、バリウム、カドミウム、水銀、タリウム、アンチモン、ゲルマニウム、およびそれらの組み合わせからなる群から選択される、請求項7に記載のデバイス。The metals are platinum, ruthenium, rhodium, iridium, manganese, magnesium, tungsten, zirconium, chromium, gold, iron, aluminum, thallium, gallium, copper, silver, brass, zinc, tin, nickel, palladium, titanium, cobalt, The device according to claim 7, wherein the device is selected from the group consisting of indium, bismuth, lead, lanthanum, hafnium, ittrium, calcium, strontium, barium, cadmium, mercury, thallium, antimony, germanium, and combinations thereof. 前記誘電体材料が有機ポリマーまたは無機ポリマーを含む、請求項1-8のいずれか1項に記載のデバイス。The device according to any one of claims 1-8, wherein the dielectric material comprises an organic polymer or an inorganic polymer. 前記誘電体材料がセラミックを含む、請求項1-8のいずれか1項に記載のデバイス。The device according to any one of claims 1-8, wherein the dielectric material comprises ceramic. 前記誘電体材料が約2-約10の誘電定数を有する、請求項1-8のいずれか1項に記載のデバイス。The device according to any one of claims 1-8, wherein the dielectric material has a dielectric constant of about 2-about 10. 前記層が、シリコン、酸化ケイ素、窒化ケイ素、炭化ケイ素、酸化チタン、ゲルマニウム、ポリテトラフルオロエチレン、ネオプレン、ポリフッ化ビニリデン、二酸化ケイ素、二酸化チタン、フルオロシリケートガラス、ポリイミド、フッ素化ポリイミド、メチルシルセスキオキサン、ポリアリーレンエーテル、ポリエチレン、ポリスチレン、炭酸カルシウム、およびそれらの組み合わせからなる群から選択される材料を含む、請求項1-8のいずれか1項に記載のデバイス。The layers are silicon, silicon oxide, silicon nitride, silicon carbide, titanium oxide, germanium, polytetrafluoroethylene, neoprene, polyvinylidene fluoride, silicon dioxide, titanium dioxide, fluorosilicate glass, polyimide, fluorinated polyimide, methylsilsesqui. The device according to any one of claims 1-8, comprising a material selected from the group consisting of oxane, polyarylene ether, polyethylene, polystyrene, calcium carbonate, and combinations thereof. 前記電極が導電性材料を含む、請求項1-12のいずれか1項に記載のデバイス。The device according to any one of claims 1-12, wherein the electrodes include a conductive material. 前記誘電体材料対導電性材料の比が約0.01:2-約99:1である、請求項13に記載のデバイス 13. The device of claim 13, wherein the dielectric material to conductive material ratio is about 0.01: 2-about 99: 1 . 前記誘電体材料対導電性材料の比が約0.3:2である、請求項13に記載のデバイス。13. The device of claim 13, wherein the dielectric material to conductive material ratio is about 0.3: 2. 前記導電性材料が、白金、金、アルミニウム、タンタル、ガリウムヒ素、銅、銀、真ちゅう、亜鉛、スズ、ニッケル、シリコン、パラジウム、チタン、グラファイト、カーボン、およびそれらの組み合わせからなる群のうちの少なくとも1つを含む、請求項13-15のいずれか1項に記載のデバイス。The conductive material is at least in the group consisting of platinum, gold, aluminum, tantalum, gallium arsenide, copper, silver, brass, zinc, tin, nickel, silicon, palladium, titanium, graphite, carbon, and combinations thereof. The device according to any one of claims 13-15, comprising one. サンプル中の分析物を単離するための方法であって、前記方法は、A method for isolating an analyte in a sample, wherein the method is:
(a)請求項1-16のいずれか1項に記載のデバイスにサンプルを適用する工程、(A) A step of applying a sample to the device according to any one of claims 1-16.
(b)少なくとも1つの交流誘電場領域および/または交流動電場領域を生成する工程、ならびに(B) A step of generating at least one AC dielectric field region and / or an AC electrokinetic field region, and
(c)交流誘電場領域および/または交流動電場領域において分析物を単離する工程、(C) A step of isolating the analyte in the AC dielectric field region and / or the AC electrokinetic field region.
を含む、方法。Including, how.
前記層の存在が、前記層を有さないデバイスと比較した場合、表面での分析物捕捉の少なくとも5倍の増加をもたらす、請求項17に記載の方法。17. The method of claim 17, wherein the presence of the layer results in at least a 5-fold increase in capture of the analyte on the surface when compared to a device without the layer. 少なくとも1つの析出技術を使用して電極上に層を析出することを含む、請求項1-16のいずれか1項に記載のデバイスを製造するための方法。The method for manufacturing any one of claims 1-16, comprising precipitating a layer onto an electrode using at least one precipitation technique. 請求項1-16のいずれか1項に記載のデバイスにサンプルを適用する工程を含む、患者の疾患または状態を診断またはモニタリングする方法。A method of diagnosing or monitoring a patient's disease or condition comprising applying a sample to the device according to any one of claims 1-16.
JP2020554865A 2018-04-02 2019-04-01 Dielectric material Pending JP2021520218A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023213223A JP2024037944A (en) 2018-04-02 2023-12-18 Dielectric materials

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862651659P 2018-04-02 2018-04-02
US62/651,659 2018-04-02
PCT/US2019/025242 WO2019195196A1 (en) 2018-04-02 2019-04-01 Dielectric materials

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023213223A Division JP2024037944A (en) 2018-04-02 2023-12-18 Dielectric materials

Publications (2)

Publication Number Publication Date
JP2021520218A JP2021520218A (en) 2021-08-19
JPWO2019195196A5 true JPWO2019195196A5 (en) 2022-04-08

Family

ID=68101165

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020554865A Pending JP2021520218A (en) 2018-04-02 2019-04-01 Dielectric material
JP2023213223A Pending JP2024037944A (en) 2018-04-02 2023-12-18 Dielectric materials

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023213223A Pending JP2024037944A (en) 2018-04-02 2023-12-18 Dielectric materials

Country Status (6)

Country Link
US (2) US11883833B2 (en)
EP (1) EP3774059A4 (en)
JP (2) JP2021520218A (en)
CN (2) CN117065932A (en)
AU (1) AU2019248621A1 (en)
WO (1) WO2019195196A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115487880A (en) 2016-03-24 2022-12-20 生物动力学公司 Disposable fluidic cartridge and assembly
WO2018208820A1 (en) 2017-05-08 2018-11-15 Biological Dynamics, Inc. Methods and systems for analyte information processing
AU2018388641B2 (en) 2017-12-19 2023-09-07 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
CN117065932A (en) 2018-04-02 2023-11-17 生物动力学公司 Dielectric material
CN114758892A (en) * 2022-05-09 2022-07-15 弘润清源(北京)科技有限责任公司 Preparation method of dielectric gel matrix
WO2024064914A1 (en) * 2022-09-22 2024-03-28 Sigil Biosciences, Inc. Devices and systems for isolating particles in solution by particle permitivity

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
DE4139472C1 (en) 1991-11-29 1993-03-11 Gerhard Dr. 8011 Kirchheim De Weber
US5965362A (en) 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6071394A (en) 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
EP0901634B1 (en) 1996-05-30 2002-03-20 Radiometer Medical A/S A system for determining at least one parameter of at least one sample of a physiological liquid and a cassette
GB9615775D0 (en) 1996-07-26 1996-09-04 British Tech Group Apparatus and method for characterising particles using dielectrophoresis
US5958791A (en) 1996-09-27 1999-09-28 Innovative Biotechnologies, Inc. Interdigitated electrode arrays for liposome-enhanced immunoassay and test device
GB2319067B (en) 1996-11-06 2000-06-28 T & N Technology Ltd Forming a bearing
DE59907639D1 (en) 1998-06-26 2003-12-11 Evotec Ag ELECTRODE ARRANGEMENT FOR DIELECTROPHORETIC PARTICLE DEFLECTION
US6203683B1 (en) 1998-11-09 2001-03-20 Princeton University Electrodynamically focused thermal cycling device
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
CN1181337C (en) 2000-08-08 2004-12-22 清华大学 Solid molecule operating method in microfluid system
US6352838B1 (en) * 1999-04-07 2002-03-05 The Regents Of The Universtiy Of California Microfluidic DNA sample preparation method and device
AU6494300A (en) 1999-08-17 2001-03-13 Porex Technologies Corporation Self-sealing materials and devices comprising same
US6824664B1 (en) 1999-11-04 2004-11-30 Princeton University Electrode-less dielectrophorises for polarizable particles
US7420659B1 (en) 2000-06-02 2008-09-02 Honeywell Interantional Inc. Flow control system of a cartridge
CA2413194A1 (en) 2000-06-14 2001-12-20 Board Of Regents, The University Of Texas System Systems and methods for cell subpopulation analysis
EP1309863A1 (en) 2000-08-08 2003-05-14 Aviva Biosciences Corporation Methods for manipulating moieties in microfluidic systems
CN100392384C (en) 2000-10-09 2008-06-04 清华大学 Entity molecule separating process on chip and required device and reagent
US6880576B2 (en) 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US7014744B2 (en) 2001-08-24 2006-03-21 Applera Corporation Method of purification and concentration using AC fields with a transfer tip
US6557575B1 (en) 2001-11-19 2003-05-06 Waters Investments Limited Fluid flow control freeze/thaw valve for narrow bore capillaries or microfluidic devices
US7081189B2 (en) 2001-12-18 2006-07-25 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
US6887362B2 (en) 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
US20040011650A1 (en) 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
GB2392977A (en) 2002-09-13 2004-03-17 Suisse Electronique Microtech A fluidic dielectrophoretic system and method for analysing biomolecules
US20040086872A1 (en) 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
EP1583956A4 (en) 2002-12-20 2009-07-15 Univ Texas Methods and apparatus for electrosmear analysis
DE10311716A1 (en) 2003-03-17 2004-10-14 Evotec Oai Ag Method and device for separating particles in a liquid flow
CN100417936C (en) 2003-03-21 2008-09-10 博奥生物有限公司 Micro device with magnetic shaft and its using method
EP1651943A2 (en) 2003-06-27 2006-05-03 Purdue Research Foundation Device for detecting biological and chemical particles
AU2004262301A1 (en) 2003-07-25 2005-02-10 Platypus Technologies, Llc Liquid crystal based analyte detection
US8256246B2 (en) 2003-10-29 2012-09-04 Miele & Cie. Kg. Aggregate for a washing machine with a plastic sudsing container
WO2006019407A2 (en) 2004-02-18 2006-02-23 The Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US7395867B2 (en) 2004-03-17 2008-07-08 Stinger Wellhead Protection, Inc. Hybrid wellhead system and method of use
JPWO2005121767A1 (en) 2004-05-25 2008-04-10 有限会社フルイド Microfluidic device and analytical fractionation apparatus using the same
US7447922B1 (en) 2004-06-23 2008-11-04 Cypress Semiconductor Corp. Supplying power from peripheral to host via USB
JP2006047153A (en) 2004-08-05 2006-02-16 Sony Corp Manufacturing method and manufacturing system of dna chip, detection method and detection system of hybridization, and substrate processing device and substrate processing method
JP4645110B2 (en) 2004-09-15 2011-03-09 ソニー株式会社 Hybridization detection unit using dielectrophoresis, sensor chip including the detection unit, and hybridization detection method
US7047832B1 (en) 2004-11-08 2006-05-23 Oporgenics, Inc., Llc Apparatus for measuring gas exchange
JP2006135191A (en) 2004-11-08 2006-05-25 Tdk Corp Solid electrolytic capacitor and manufacturing method thereof
US7918244B2 (en) 2005-05-02 2011-04-05 Massachusetts Institute Of Technology Microfluidic bubble logic devices
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
IES20050304A2 (en) 2005-05-11 2006-11-15 Haemoglobal Biotech Ltd A mobile chemistry and haematology analyser with an intergrated diagnostic databank
EP1764418B1 (en) 2005-09-14 2012-08-22 STMicroelectronics Srl Method and device for the treatment of biological samples using dielectrophoresis
US20070080062A1 (en) 2005-10-03 2007-04-12 Harnett Cindy K Coated metal structures and methods of making and using thereof
WO2007102839A2 (en) 2005-10-27 2007-09-13 Applera Corporation Optoelectronic separation of biomolecules
CN101365781A (en) 2005-11-21 2009-02-11 阿普尔拉公司 Portable preparation, analysis, and detection apparatus for nucleic acid processing
TWI304752B (en) 2005-12-09 2009-01-01 Ind Tech Res Inst Multi-sample microfluidic dielectrophoresis separator
KR100745754B1 (en) 2005-12-29 2007-08-02 삼성전자주식회사 A device for manipulating a particle using dielectrophoresis comprising a metal post electrode structure and a method of manipulating a particle with high flow rate using the same
DE102006002462A1 (en) 2006-01-18 2007-07-19 Evotec Technologies Gmbh Electric field cage and associated operating method
US20090061450A1 (en) 2006-03-14 2009-03-05 Micronics, Inc. System and method for diagnosis of infectious diseases
WO2007106552A2 (en) 2006-03-14 2007-09-20 Micronics, Inc. System and method for diagnosis of infectious diseases
JP2009530634A (en) 2006-03-21 2009-08-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Microelectronic device with field electrode group
WO2007116406A1 (en) 2006-04-10 2007-10-18 Technion Research & Development Foundation Ltd. Method and device for electrokinetic manipulation
KR100813254B1 (en) 2006-05-29 2008-03-13 삼성전자주식회사 An apparatus for separating a polarizable analyte using dielectrophoresis and a method of separating a polarizable analyte using the same
US7552113B2 (en) 2006-11-16 2009-06-23 Roe Robert D System and method for managing search results and delivering advertising and enhanced effectiveness
JP2008298575A (en) 2007-05-31 2008-12-11 Panasonic Corp Electrode, manufacturing method, and apparatus and method for detection using the same
EP2186034A2 (en) 2007-07-26 2010-05-19 T2 Biosystems, Inc. Diagnostic information generation and use
US8713603B2 (en) 2008-03-10 2014-04-29 Hulu, LLC Method and apparatus for user selection of advertising combinations
WO2009146143A2 (en) 2008-04-03 2009-12-03 The Regents Of The University Of California Ex-vivo multi-dimensional system for the separation and isolation of cells, vesicles, nanoparticles and biomarkers
FI20085299A0 (en) 2008-04-10 2008-04-10 Valtion Teknillinen Microfluidic chip devices and their use
JP2011521215A (en) 2008-05-14 2011-07-21 エーテーハー チューリヒ Biomarker and drug target discovery method for diagnosis and treatment of prostate cancer, and biomarker assay determined using the same
GB0809486D0 (en) 2008-05-23 2008-07-02 Iti Scotland Ltd Triple function elctrodes
US20090325813A1 (en) 2008-06-26 2009-12-31 Hui Wang Methods and kits for quantitative oligonucleotide analysis
WO2010039902A2 (en) * 2008-09-30 2010-04-08 Shocking Technologies, Inc. Voltage switchable dielectric material containing conductive core shelled particles
WO2010050898A1 (en) 2008-10-31 2010-05-06 Agency For Science, Technology And Research Device and method for detection of analyte from a sample
US20100211407A1 (en) 2009-02-13 2010-08-19 Duke David O Method and system for providing a patient therapeutic plan
US8192603B2 (en) 2008-12-29 2012-06-05 Basf Coatings Gmbh Electrocoat composition and process replacing phosphate pretreatment
US10262761B1 (en) 2009-01-01 2019-04-16 Michael D Weintraub Apparatus and methods for causing selection of an advertisement based on prevalence of a healthcare condition in a plurality of geographic areas
WO2010111265A1 (en) 2009-03-24 2010-09-30 University Of Chicago Slip chip device and methods
EP2253352A1 (en) 2009-05-21 2010-11-24 Debiotech S.A. Passive fluid flow regulator
US20110009724A1 (en) 2009-07-09 2011-01-13 Medtronic Minimed, Inc. Providing contextually relevant advertisements and e-commerce features in a personal medical device system
JP5306092B2 (en) 2009-07-17 2013-10-02 キヤノン株式会社 Fluid control device
DE102009028493B4 (en) 2009-08-13 2023-08-24 Robert Bosch Gmbh microfluidic cell
SG170703A1 (en) 2009-10-20 2011-05-30 Agency Science Tech & Res Microfluidic system for detecting a biological entity in a sample
WO2011057347A1 (en) 2009-11-12 2011-05-19 Tgr Biosciences Pty Ltd Analyte detection
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
MX349568B (en) 2010-11-30 2017-08-03 Univ Hong Kong Chinese Detection of genetic or molecular aberrations associated with cancer.
GB201102385D0 (en) 2011-02-10 2011-03-30 Biocule Scotland Ltd Two-dimensional gel electrophoresis apparatus and method
US20140170679A1 (en) 2011-03-07 2014-06-19 James Stewart Aitchison Method and system for cell detection and analysis
US9638663B2 (en) 2011-07-25 2017-05-02 Proxim Diagnostics Corporation Cartridge for diagnostic testing
US20130052748A1 (en) 2011-08-30 2013-02-28 Supernova Diagnostics, Inc. Assay device and method of assaying
CN102320559B (en) 2011-09-14 2014-06-18 上海交通大学 Preparation method of hollow-structured micro-array electrode
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
EP2771483A1 (en) 2011-10-25 2014-09-03 ONCOTYROL - Center for Personalized Cancer Medicine GmbH Method for diagnosing a disease based on plasma-dna distribution
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
US9023640B2 (en) 2011-12-13 2015-05-05 Fundamental Solutions Corporation Device for rapid detection of infectious agents
WO2013096804A2 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Optical assay device with pneumatic sample actuation
US9568444B2 (en) 2012-01-27 2017-02-14 University Of Tennessee Research Foundation Method and apparatus for detection of a biomarker by alternating current electrokinetics
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US20150155100A1 (en) 2012-03-30 2015-06-04 Taiyo Yuden Co., Ltd. Multi-layer ceramic capacitor and method for manufacturing the same
EP4219012A1 (en) 2012-04-03 2023-08-02 Illumina, Inc. Method of imaging a substrate comprising fluorescent features and use of the method in nucleic acid sequencing
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
KR20150014925A (en) 2012-04-16 2015-02-09 바이오로지컬 다이나믹스, 인크. Nucleic acid sample preparation
US8932815B2 (en) 2012-04-16 2015-01-13 Biological Dynamics, Inc. Nucleic acid sample preparation
WO2015196141A1 (en) 2014-06-20 2015-12-23 Biological Dynamics, Inc. Nucleic acid sample preparation
ES2831602T3 (en) 2012-07-10 2021-06-09 Becton Dickinson France Sas Integrated injection system and communications device
EP2875350A4 (en) 2012-07-18 2016-05-11 Biolog Dynamics Inc Manipulation of microparticles in low field dielectrophoretic regions
WO2014028222A1 (en) 2012-07-31 2014-02-20 Crown Bioscience, Inc. Biomarkers for identifying esophageal cancer patients for treatment with an anti-egfr drug
US9310300B2 (en) 2012-08-03 2016-04-12 Ingeneron Incorporated Compact portable apparatus for optical assay
US9551665B2 (en) 2012-10-01 2017-01-24 National Cheng Kung University Method for detecting mitochondria gene alterations
CN105263627B (en) 2013-01-18 2019-05-21 生米公司 Analytical equipment
SG11201506481QA (en) 2013-02-22 2015-09-29 Life Technologies Corp Optical systems and methods for biological analysis
WO2014151961A1 (en) 2013-03-14 2014-09-25 Life Technologies Corporation Matrix arrays and methods for making same
US9169521B1 (en) 2013-03-14 2015-10-27 The Boeing Company Point-of-collection sample preparation device and method
US20140367260A1 (en) 2013-06-14 2014-12-18 Nanophoretics Llc Method and Apparatus for Identifying Objects in a Plurality of Objects Using Dielectrophoresis
ITCO20130029A1 (en) 2013-06-28 2014-12-29 Plasmore S R L UNIT FOR BIOCHEMICAL ANALYSIS OF SPR-TYPE IMAGES IN THE FORM OF PIASTRINA
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
GB2516666B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
US9347962B2 (en) 2013-08-05 2016-05-24 Nanoscopia (Cayman), Inc. Handheld diagnostic system with chip-scale microscope and automated image capture mechanism
WO2015038797A1 (en) 2013-09-13 2015-03-19 The Board Of Trustees Of The Leland Stanford Junior University Plasmonic beads for multiplexed analysis by flow detection systems
US9701892B2 (en) 2014-04-17 2017-07-11 Baker Hughes Incorporated Method of pumping aqueous fluid containing surface modifying treatment agent into a well
US20170016814A1 (en) 2013-12-27 2017-01-19 Hitachi, Ltd. Biomolecule analysis device
WO2015148808A1 (en) 2014-03-26 2015-10-01 Zhenyu Li Handheld fluid handling systems and methods
EP3129481A4 (en) * 2014-04-08 2017-10-25 Biological Dynamics, Inc. Improved devices for separation of biological materials
GB2558097B (en) 2014-04-17 2019-03-06 Z Integrated Digital Tech Inc Electronic test device data communication
EP3148697A1 (en) 2014-05-27 2017-04-05 Illumina, Inc. Systems and methods for biochemical analysis including a base instrument and a removable cartridge
AU2015302059B2 (en) 2014-08-12 2020-02-06 Nextgen Jane, Inc. System and method for monitoring health based on collected bodily fluid
WO2016025698A1 (en) 2014-08-13 2016-02-18 The Trustees Of Columbia University In The City Of New York Diagnostic devices, systems, and methods
JP6820839B2 (en) 2014-12-24 2021-01-27 ラムダジェン コーポレイション Mobile / wearable device that captures LSPR sensor
US10360583B2 (en) 2015-02-05 2019-07-23 Direct Path, Llc System and method for direct response advertising
US20180345284A1 (en) 2015-05-04 2018-12-06 Biological Dynamics, Inc. Particle based immunoassay with alternating current electrokinetics
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
US10664572B2 (en) 2015-08-06 2020-05-26 Microsoft Technology Licensing, Llc Recommendations for health benefit resources
US10242713B2 (en) 2015-10-13 2019-03-26 Richard A. ROTHSCHILD System and method for using, processing, and displaying biometric data
KR102426825B1 (en) * 2015-10-27 2022-07-28 버클리 라잇츠, 인크. Microfluidic Electrowetting Device Apparatus With Covalently Bound Hydrophobic Surfaces
US10379101B2 (en) * 2015-11-23 2019-08-13 Hai Kang Life Corporation Limited Apparatus for detection of biomolecules and its fabrication
US11042908B2 (en) 2015-12-03 2021-06-22 Salucro Healthcare Solutions, LLC System and method for health risk evaluation
US10444184B2 (en) 2015-12-28 2019-10-15 International Business Machines Corporation Operation of diagnostic devices involving microchannels and electrodes
WO2017125475A1 (en) 2016-01-19 2017-07-27 Eth Zurich Device, system, and method for manipulating objects, particularly micro- or nano-objects, and method for fabricating a device for manipulating objects, particularly micro- or nano-objects
CN115487880A (en) 2016-03-24 2022-12-20 生物动力学公司 Disposable fluidic cartridge and assembly
EP3909686A1 (en) 2016-04-15 2021-11-17 Fluid-Screen, Inc. Analyte detection methods and apparatus using dielectrophoresis and electroosmosis
WO2018208820A1 (en) 2017-05-08 2018-11-15 Biological Dynamics, Inc. Methods and systems for analyte information processing
GB201711066D0 (en) 2017-07-10 2017-08-23 Univ Oxford Innovation Ltd Method
AU2018388641B2 (en) 2017-12-19 2023-09-07 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
AU2018392601A1 (en) 2017-12-19 2020-07-30 Biological Dynamics, Inc. Methods and devices for detecting and quantifying cell-free DNA fragments
CN117065932A (en) 2018-04-02 2023-11-17 生物动力学公司 Dielectric material
WO2019200323A1 (en) 2018-04-13 2019-10-17 Molecular Surface Technologies, Llc Electrochemical attachment of phosphonic acids to metallic substrates and osteoconductive medical devices containing same
AU2021304354A1 (en) 2020-07-10 2023-03-02 Biological Dynamics, Inc. Modification of metallic surfaces with phosphonic acids
CA3204790A1 (en) 2021-01-12 2022-07-21 Rajaram Krishnan Methods and systems for detection and discovery of biomarkers

Similar Documents

Publication Publication Date Title
US20150021716A1 (en) Low power micro semiconductor gas sensor and method of manufacturing the same
US20060249384A1 (en) Chemical sensor
US9546995B2 (en) Nanopore device including graphene nanopore and method of manufacturing the same
US8497499B2 (en) Method to modify the conductivity of graphene
US7762121B2 (en) Method and apparatus for sensing hydrogen gas
JPH11205898A (en) Electrode for dielectric thin-film element, its manufacture and ultrasonic oscillator using the electrode
US10746691B1 (en) Ion-sensitive field effect transistor (ISFET) with enhanced sensitivity
US20180038816A1 (en) Miniature gas sensor and method for manufacturing the same
EP2762866A1 (en) CMOS gas sensor and method for manufacturing the same
US20170117367A1 (en) Scalable process for the formation of self aligned, planar electrodes for devices employing one or two dimensional lattice structures
WO2014007603A2 (en) A method of fabricating a gas sensor
JPWO2019195196A5 (en)
US10656129B2 (en) Miniature gas sensor
KR101665020B1 (en) GAS SENSOR and Method for Manufacturing GAS SENSOR
US20230384166A1 (en) Bolometer and method for manufacturing same
JP4947600B2 (en) Thin film gas sensor
KR100511268B1 (en) Method for manufacturing gas sensor
JP2005030907A (en) Gas sensor
JP4103027B2 (en) Thin film gas sensor
JPH10208902A (en) Production of organic ptc thermistor
KR102228652B1 (en) Photodiode type self-powered gas sensor and preparation method thereof
US10935516B2 (en) Ion-sensitive field-effect transistor formed with alternating dielectric stack to enhance sensitivity
RU2426194C1 (en) Method of fabricating nanostructure ohmic contact of photoelectric transducer
JP2005037349A (en) Thin film gas sensor and manufacturing method therefor
JP2003279523A (en) Membrane gas sensor