JPWO2019186553A5 - - Google Patents

Claims (14)

A composition comprising intact mitochondria and / or ruptured mitochondria for use in an increase in lipid and cholesterol metabolism in a subject requiring an increase in lipid and cholesterol metabolism , wherein said mitochondria are present in a placenta, culture. A composition derived from a grown placenta cell, blood cell, plant tissue, plant cell, or plant cell grown in a culture . Elevating lipid and cholesterol metabolism consists of blood levels of total cholesterol, LDL cholesterol, triglycerides, fatty acids and / or triglycerides in adipocytes, or any combination thereof. The composition of claim 1 , comprising reducing at least one parameter selected from the group. A non-therapeutic method of inducing weight loss or reducing or reducing weight gain in a subject in need of inducing or reducing or reducing weight gain, wherein the subject has intact mitochondria and / or ruptured mitochondria. A method comprising administering an effective amount of a composition comprising. The composition or method according to any one of claims 1 to 3 , wherein the composition containing the ruptured mitochondria further comprises at least one mitochondrial component released from the ruptured mitochondria. The composition according to claim 4 , wherein the constituent is selected from the group consisting of mitochondrial proteins, mitochondrial nucleic acids, mitochondrial lipids, mitochondrial peptides, mitochondrial sugars, mitochondrial structures, at least a portion of mitochondrial matrix, and combinations thereof. Or how . The composition or method according to any one of claims 1 to 3 , wherein the composition containing the intact mitochondria further comprises a hypertonic solution. 1. The mitochondria are isolated mitochondria, and the weight of the mitochondrial protein in the isolated mitochondria constitutes more than 80% of the total weight of the mitochondria and other intracellular cellular proteins. The composition or method according to any one of 6 to 6 . The mitochondria are partially purified mitochondria, and the weight of the mitochondrial protein in the partially purified mitochondria constitutes 10% to 80% of the total weight of the mitochondria and other intracellular proteins. However , preferably, any of claims 1 to 6 , wherein the weight of the mitochondrial protein in the partially purified mitochondria constitutes 20% to 40% of the total weight of the mitochondria and other intracellular proteins. The composition or method according to paragraph 1. The composition or method according to any one of claims 1 to 8 , wherein the mitochondria undergo a freeze-thaw cycle. The composition or method according to claim 1 , wherein the mitochondria are derived from mung bean sprouts. The composition is administered to the subject in need of the composition by a route selected from the group consisting of enteral, parenteral, intravenous, intraarterial, subcutaneous, oral, and direct injection into a tissue or organ. The composition or method according to any one of claims 1 to 10 , wherein the composition is preferably administered by oral administration or to the adipose tissue of a subject . The composition according to any one of claims 1 , 2, and 4 to 11 , for use in the treatment or prevention of diseases that benefit from elevated lipid and cholesterol metabolism. The disease benefiting from elevated lipid and cholesterol metabolism is selected from the group consisting of obesity, diseases associated with increased intraperitoneal adipose tissue, visceral obesity, visceral adipose tissue syndrome, and fatty liver disease . Item 12. The composition according to Item 12. The composition according to claim 12 or 13 , wherein the disease benefiting from elevated lipid and cholesterol metabolism is obesity.