JPWO2019175776A5 - - Google Patents

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JPWO2019175776A5
JPWO2019175776A5 JP2020548916A JP2020548916A JPWO2019175776A5 JP WO2019175776 A5 JPWO2019175776 A5 JP WO2019175776A5 JP 2020548916 A JP2020548916 A JP 2020548916A JP 2020548916 A JP2020548916 A JP 2020548916A JP WO2019175776 A5 JPWO2019175776 A5 JP WO2019175776A5
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Japan
Prior art keywords
cancer
compound
salt
pharmaceutical
mammal
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JP2020548916A
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Japanese (ja)
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JP7266942B2 (en
JP2021518335A (en
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Priority claimed from PCT/IB2019/052009 external-priority patent/WO2019175776A1/en
Publication of JP2021518335A publication Critical patent/JP2021518335A/en
Publication of JPWO2019175776A5 publication Critical patent/JPWO2019175776A5/ja
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Claims (7)

哺乳動物における異常細胞増殖を治療するための医薬であって、請求項1~29のいずれか一項に記載の化合物もしくは塩を、治療学的に有効な量にて含む前記医薬 A pharmaceutical agent for treating abnormal cell proliferation in a mammal, which comprises the compound or salt according to any one of claims 1 to 29 in a therapeutically effective amount. 前記化合物もしくは塩が抗体医薬複合体の一成分である、請求項33に記載の医薬The drug according to claim 33, wherein the compound or salt is a component of an antibody pharmaceutical complex. 前記の化合物もしくは塩が粒子ベース送達システムの一成分である、請求項33に記載の医薬33. The pharmaceutical according to claim 33, wherein the compound or salt is a component of a particle-based delivery system. 異常細胞増殖がガンである、請求項33に記載の医薬33. The pharmaceutical art according to claim 33, wherein the abnormal cell proliferation is cancer. ガンが、肺ガン、骨ガン、膵臓ガン、皮膚ガン、頭頚部ガン、皮膚もしくは眼球内黒色腫、子宮ガン、卵巣ガン、直腸ガン、肛門部ガン、胃ガン、結腸ガン、乳ガン、子宮ガン、卵管ガン、子宮内膜ガン、頸ガン、膣ガン、外陰ガン、ホジキン病、食道ガン、小腸ガン、内分泌系ガン、甲状腺ガン、副甲状腺ガン、副腎ガン、軟部組織肉腫、尿道ガン、陰茎ガン、前立腺ガン、慢性もしくは急性白血病、リンパ球性リンパ腫、膀胱ガン、腎臓もしくは尿管のガン、腎細胞ガン、腎孟ガン、中枢神経系(CNS)腫瘍、中枢神経系原発リンパ腫、脊髄軸腫瘍、脳幹グリオーマ、又は下垂体腺腫である、請求項36に記載の医薬Cancers include lung cancer, bone cancer, pancreatic cancer, skin cancer, head and neck cancer, skin or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer, anal cancer, stomach cancer, colon cancer, breast cancer, uterine cancer, Oviductal cancer, endometrial cancer, cervical cancer, vaginal cancer, genital cancer, Hodgkin's disease, esophageal cancer, small intestinal cancer, endocrine cancer, thyroid cancer, parathyroid cancer, adrenal cancer, soft tissue sarcoma, urinary tract cancer, penis cancer , Prostate cancer, chronic or acute leukemia, lymphocytic lymphoma, bladder cancer, kidney or urinary tract cancer, renal cell cancer, renal meng cancer, central nervous system (CNS) tumor, central nervous system primary lymphoma, spinal axis tumor, 36. The apparatus of claim 36, which is a brain stem glioma or pituitary adenoma . 哺乳動物におけるSTINGの活性をアップレギュレートするための医薬であって、請求項1~29のいずれか一項に記載の化合物もしくは塩の有効量を含む前記医薬 A pharmaceutical agent for upregulating the activity of STING in a mammal, which comprises an effective amount of the compound or salt according to any one of claims 1 to 29. 哺乳動物におけるインターフェロンβのレベルを増大させるための医薬であって、請求項1~29のいずれか一項に記載の化合物もしくは塩の有効量を含む前記医薬 A pharmaceutical agent for increasing the level of interferon β in a mammal, which comprises an effective amount of the compound or salt according to any one of claims 1 to 29.
JP2020548916A 2018-03-15 2019-03-12 Cyclopentane-based modulators of STING (interferon gene stimulator) Active JP7266942B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862643467P 2018-03-15 2018-03-15
US62/643,467 2018-03-15
US201862666204P 2018-05-03 2018-05-03
US62/666,204 2018-05-03
US201862742532P 2018-10-08 2018-10-08
US62/742,532 2018-10-08
US201962809990P 2019-02-25 2019-02-25
US62/809,990 2019-02-25
PCT/IB2019/052009 WO2019175776A1 (en) 2018-03-15 2019-03-12 Cyclopentane-based modulators of sting (stimulator of interferon genes)

Publications (3)

Publication Number Publication Date
JP2021518335A JP2021518335A (en) 2021-08-02
JPWO2019175776A5 true JPWO2019175776A5 (en) 2022-03-16
JP7266942B2 JP7266942B2 (en) 2023-05-01

Family

ID=66103038

Family Applications (1)

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JP2020548916A Active JP7266942B2 (en) 2018-03-15 2019-03-12 Cyclopentane-based modulators of STING (interferon gene stimulator)

Country Status (24)

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US (4) US10538542B2 (en)
EP (1) EP3765474B1 (en)
JP (1) JP7266942B2 (en)
KR (1) KR20200131878A (en)
CN (1) CN111918871A (en)
AU (1) AU2019234043A1 (en)
BR (1) BR112020018593A2 (en)
CA (1) CA3093631C (en)
CL (1) CL2020002352A1 (en)
CR (1) CR20200382A (en)
DO (1) DOP2020000160A (en)
EC (1) ECSP20057847A (en)
ES (1) ES2923298T3 (en)
IL (1) IL277278A (en)
MA (1) MA52012A (en)
MX (1) MX2020009587A (en)
NI (1) NI202000058A (en)
PE (1) PE20210412A1 (en)
PH (1) PH12020551486A1 (en)
RU (1) RU2020130048A (en)
SG (1) SG11202008102VA (en)
TW (1) TWI741268B (en)
UY (1) UY38145A (en)
WO (1) WO2019175776A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111511754B (en) 2017-12-20 2023-09-12 捷克共和国有机化学与生物化学研究所 2'3' cyclic dinucleotides with phosphonate bonds of activated STING adaptor protein
EP3728283B1 (en) 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
KR20200140867A (en) 2018-04-06 2020-12-16 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. 3'3'-cyclic dinucleotide
TW202028179A (en) 2018-10-08 2020-08-01 美商普萊恩醫療公司 Amino acid compounds and methods of use
WO2021059136A1 (en) * 2019-09-25 2021-04-01 Pfizer Inc. Polyheterocyclic modulators of sting (stimulator of interferon genes)
WO2021206158A1 (en) 2020-04-10 2021-10-14 小野薬品工業株式会社 Method of cancer therapy
US11964978B2 (en) * 2021-03-18 2024-04-23 Pfizer Inc. Modulators of STING (stimulator of interferon genes)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (en) 1990-01-23 1999-01-15 . Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
KR20170015353A (en) * 2014-06-04 2017-02-08 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Cyclic di-nucleotides as modulators of sting
GB201501462D0 (en) * 2015-01-29 2015-03-18 Glaxosmithkline Ip Dev Ltd Novel compounds

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