JPWO2019152986A5 - - Google Patents

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JPWO2019152986A5
JPWO2019152986A5 JP2020539714A JP2020539714A JPWO2019152986A5 JP WO2019152986 A5 JPWO2019152986 A5 JP WO2019152986A5 JP 2020539714 A JP2020539714 A JP 2020539714A JP 2020539714 A JP2020539714 A JP 2020539714A JP WO2019152986 A5 JPWO2019152986 A5 JP WO2019152986A5
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repolarization
signal
map
electrode
heart
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JP2021512663A (en
JP7396988B2 (en
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Claims (13)

心不整脈を治療する方法であって、
マッピングカテーテルの遠位部分が患者の心臓に挿入されて、第1の電極が第1の位置に置かれている間に、前記マッピングカテーテルの前記遠位部分上の前記第1の電極から再分極信号を受信することと、
前記第1の電極から受信した前記再分極信号をフィルタリングすることと、
前記第1の電極を介して前記心臓に刺激を与えることと、
前記心臓の再分極マップを作成することと、
前記第1の電極を介して心臓に電気穿孔を与えることであって、前記電気穿孔を与えることは、不可逆的な電気穿孔、又は、可逆的な電気穿孔を与えることを含む、前記電気穿孔を与えることと、
前記心臓に対して外部にある、第2の位置の第2の電極から外部信号を受信することと、
前記第1の電極からの前記再分極信号によって前記外部信号を較正することであって、前記外部信号を較正することは、基線と交差するT波の下に向かう傾斜を測定することを含む、前記外部信号を較正することと、
を含む方法。
A way to treat cardiac arrhythmias
Repolarization from the first electrode on the distal portion of the mapping catheter while the distal portion of the mapping catheter is inserted into the patient's heart and the first electrode is placed in the first position. Receiving a signal and
Filtering the repolarization signal received from the first electrode and
Stimulating the heart through the first electrode and
Creating the repolarization map of the heart and
To provide an electroporation to the heart via the first electrode, wherein providing the electroporation comprises providing an irreversible or reversible electroporation. Giving and
Receiving an external signal from the second electrode at the second position, which is external to the heart.
To calibrate the external signal with the repolarization signal from the first electrode, calibrating the external signal comprises measuring the downward slope of the T wave intersecting the baseline. Calibrating the external signal and
How to include.
前記再分極信号をフィルタリングすることは、前記再分極信号からの雑音を低減させることを含む、請求項1に記載の方法。 The method of claim 1, wherein filtering the repolarized signal comprises reducing noise from the repolarized signal. 前記再分極信号をフィルタリングすることは、
前記再分極信号の微分を計算することと、
前記再分極信号から派生信号を除去することと、
を含む、請求項に記載の方法。
Filtering the repolarization signal
Computing the derivative of the repolarization signal and
Removing the derivative signal from the repolarization signal and
The method according to claim 1 .
前記第1の位置及び前記第2の位置は、前記心臓の同様の領域からの信号を受信する、請求項に記載の方法。 The method of claim 1 , wherein the first position and the second position receive signals from similar regions of the heart. 前記外部信号を較正することは、前記第2の電極を第3の位置へ動かすことをさらに含み、及び、前記心臓の前記再分極マップを作成することは、前記外部信号を使用して前記再分極マップを作成することを含む、請求項に記載の方法。 Calibrating the external signal further comprises moving the second electrode to a third position, and creating the repolarization map of the heart is the repolarization using the external signal. The method of claim 1 , comprising creating a polarization map. 前記外部信号を較正することは、前記外部信号の一次微分を入手することを含む、請求項に記載の方法。 The method of claim 1 , wherein calibrating the external signal comprises obtaining a first derivative of the external signal. 前記電気穿孔を行うことによって引き起こされた電気穿孔信号を受信することと、前記再分極信号に対する前記電気穿孔の予測可能な効果を検出することと、をさらに含む、請求項に記載の方法。 The method of claim 1 , further comprising receiving an electroporation signal caused by performing the electroporation and detecting the predictable effect of the electroporation on the repolarization signal. 刺激を与えることは、前記刺激によって前記患者の心拍数を変化させることをさらに含み、前記患者の前記心拍数を変化させることによって、前記患者の前記再分極信号の変化を引き起こす、請求項に記載の方法。 The stimulus further comprises changing the patient's heart rate by the stimulus, and changing the patient's heart rate causes a change in the patient's repolarization signal , claim 1 . The method described in. 前記再分極マップを作成することは、磁石を用いたナビゲーション及びポイント入手によって前記再分極マップを作成することを含む、請求項に記載の方法。 The method of claim 1 , wherein creating the repolarization map comprises creating the repolarization map by navigation using a magnet and obtaining points. 前記再分極マップを作成することは、前記再分極信号における基準点を決定することを含む、請求項に記載の方法。 The method of claim 1 , wherein creating the repolarization map comprises determining a reference point in the repolarization signal. 前記再分極マップを作成することは、前記再分極マップを作成するために前記基準点を使用することを含み、前記基準点は、再分極の終了である、請求項10に記載の方法。 10. The method of claim 10 , wherein creating the repolarization map comprises using the reference point to create the repolarization map, wherein the reference point is the end of repolarization . 正常な再分極マップからの前記再分極マップの変異を決定することをさらに含む、請求項に記載の方法。 The method of claim 1 , further comprising determining a mutation in the repolarization map from a normal repolarization map. 前記再分極マップの変異を決定することは、前記再分極マップを前記正常な再分極マップと比較することと、前記再分極マップと前記正常な再分極マップとの間の差を検出することと、を含む、請求項12に記載の方法。

Determining the variation of the repolarization map is to compare the repolarization map with the normal repolarization map and to detect the difference between the repolarization map and the normal repolarization map. , The method of claim 12 .

JP2020539714A 2018-02-05 2019-02-05 Systems and methods for mapping and adjusting repolarization Active JP7396988B2 (en)

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US201862626448P 2018-02-05 2018-02-05
US62/626,448 2018-02-05
PCT/US2019/016644 WO2019152986A1 (en) 2018-02-05 2019-02-05 Systems and methods for mapping and modulating repolarization

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JPWO2019152986A5 true JPWO2019152986A5 (en) 2022-02-08
JP7396988B2 JP7396988B2 (en) 2023-12-12

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