JPWO2019086720A5 - - Google Patents

Description

Individual compounds of the invention include:
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 1),
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 2),
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-5-benzoyl-2,6-dimethyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-phenyl-1,4-dihydropyridine-3-carboxylate,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-nicotinoyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydro-[2,3′-bipyridine]-3-carboxylate,
2,2,2-trifluoroethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(4-methylpiperazine-1-carbonyl)-1,4-dihydropyridin-3-yl)ethane-1- on,
5-acetyl-4-(benzo[b]thiophen-3-yl)-N,N-diethyl-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(morpholine-4-carbonyl)-1,4-dihydropyridin-3-yl)ethan-1-one,
2-methoxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-acetamidopropyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
2-morpholinoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-(dimethylamino)ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-acetamidoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(methoxymethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((dimethylamino)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-methoxybenzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-2-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(morpholino-methyl)-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(benzo[b]thiophen-3-yl)-2,6-bis(morpholinomethyl)-1,4-dihydropyridine-3,5-dicarboxylate,
2-hydroxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethan-1-one,
Methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(1-(tert-butoxycarbonyl)azetidin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxy rate,
(1-(tert-butoxycarbonyl)piperidin-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate ,
cyclohexylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-N-phenyl-1,4-dihydropyridine-3-carboxamide,
tetrahydro-2H-pyran-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxy-2-oxoethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(2-methylbenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxyethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((benzyloxy)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(phenoxymethyl)-1,4-dihydropyridine-3-carboxylate,
phenethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-benzyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(2-phenylacetyl)-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(2-methoxyacetyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-(methoxymethyl)-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(fluoromethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(tert-butoxycarbonyl)piperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-methylpiperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclobutyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[3,2-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-6-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(Tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
benzyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-benzyl-6-methyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1-(5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3-yl)-2-phenylethan-1-one,
methyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
1-(2-methyl-5-(piperidine-1-carbonyl)-4-(thieno[2,3-b]pyridin-3-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3 -yl) ethane-1-one,
4-(((5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carbonyl)oxy)methyl)benzoic acid,
benzyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-(cyclopropylcarbamoyl)benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4 dihydropyridine-3-carboxylate,
4-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(3-fluoropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyrimidin-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(5-bromopyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(6-chloropyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-morpholinobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(2-chloropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
tetrahydro-2H-pyran-4-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
5-acetyl-N-benzyl-N,2,6-trimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxamide,
oxetane-3-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
isopropyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
Methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(2,2,2-trifluoroacetyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopentyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-diamino-4-(benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-acetamido-5-acetyl-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2,6-diamino-4-(7-cyanobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
5-(cyclopropylmethyl)3-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(4-fluorobenzyl) 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(4-fluorobenzyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 6-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-1,4-dihydropyridine-3-carboxylate,
3-cyclopentyl 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-2-amino-4-(6-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-fluorobenzyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(cyclobutylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((3,3-difluorocyclobutyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5 - a dicarboxylate,
cyclopropylmethyl 2-amino-5-carbamoyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-((2,2-difluorocyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5 - a dicarboxylate,
5-cyclopropyl 3-(cyclopropylmethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((2,2-difluorocyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3, 5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-4-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-isopropyl 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((2,2-difluoro-3,3-dimethylcyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4 - dihydropyridine-3,5-dicarboxylate,
5-methyl 3-neopentyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanothieno[3,2-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
5-methyl 3-neopentyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
bis(cyclopropylmethyl) 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-(prop-2-yn-1-yl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(5,7-dicyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate ,
5-(but-2-yn-1-yl)3-(cyclopropylmethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
5-methyl 3-(2,2,2-trifluoroethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5- dicarboxylate,
3-(Cyclopropylmethyl)5-(2,2,2-trifluoroethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(6-chloro-7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
3-(2-fluoro-2-methylpropyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-6-(trifluoromethyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3 , 5-dicarboxylate,
5-methyl 3-prop-2-yn-1-yl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarboxy rate,
4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-methyl-6-phenyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarbonitrile,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carbonitrile,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-methyl-6-phenyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-morpholinobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazin-1-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(4-(5-(benzylamino)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)bis(ethane-1- on),
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carbonitrile,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
N-cyclopropyl-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
N-(cyclopropylmethyl)-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethane -1-on),
1,1′-(2,6-dimethyl-4-(thieno[3,2-c]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
1,1′-(2,6-dimethyl-4-(thieno[2,3-c]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
1,1′-(2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
dimethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-2,3-dicarboxylate,
dimethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-2,3-dicarboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydro-pyridine-3,5-diyl)diethanone,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(methylsulfonyl)-1,4-dihydro-pyridin-3-yl)ethanone,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-(3-acetyl-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
methyl 5-acetyl-4-(5-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-((cyclopropylmethyl)carbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[3,2-c]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-c]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(5-fluorobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
3-(3-acetyl-6-cyclopropyl-5-(methoxycarbonyl)-2-methyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylic acid,
benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
bis(pyridin-4-ylmethyl) 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dibenzyl 2,6-dicyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
benzyl 5-acetyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylate,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carbonitrile,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
bis(4-fluorobenzyl) 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
4-cyanobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(trifluoromethyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-chlorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-(4-(7-bromobenzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethane-1- on,
3-chlorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3- carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine- 3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclobutyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopentyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclohexyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
3-((4-methylpiperazin-1-yl)methyl)benzyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3- carboxylate,
3-(cyclopropylmethyl)5-methyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7- cyanobenzo [b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-formyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-(hydroxymethyl)-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-formyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-cyano-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-4-(6-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 2,5-diacetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate hydrochloride,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate trifluoromethanesulfonate,
4-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
[3,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[3,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(pyridin-4-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-cyclopropylbenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-4-yl)benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
1,1′-(2,6-dimethyl-4-(5-(pyridin-3-yl)benzo[b]thiophen-3-yl)-1,4-dihydro-pyridine-3,5-diyl)diethanone ,
and methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-phenylbenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate.

（式中、
－ Ｒ^１は、
ａ）－ＣＯＲ^５、
ｂ）－ＣＯＯＲ^５、
ｃ）－ＣＮ、
ｄ）－Ｃ（Ｏ）ＮＨ_２、から選択される基であり、
－ Ｒ^５は、
ａ）直鎖又は分枝のＣ_１－Ｃ_６アルキル（前記アルキルは－Ｎ（Ｒ^６）Ｒ^７及び－ＯＲ^６、ハロゲン原子、Ｃ_３－Ｃ_６シクロアルキル及びアルキニル基から選択される１個、２個又は３個の置換基で置換されていてもよい）、
ｂ）Ｃ_３－Ｃ_６シクロアルキル、から選択される基であり、
－ Ｒ^２は、
ａ）－ＣＯＯＲ^８、
ｂ）－ＣＯＲ^８、
ｃ）－Ｃ（Ｏ）Ｎ（Ｒ^８）Ｒ^９、
ｄ）－ＣＮ、
ｅ）－Ｓ（Ｏ）_ｎＲ^８（ｎは１から２の整数）、から選択される基であり、
－ Ｒ^８及びＲ^９は、
ａ）直鎖若しくは分枝のＣ_１－Ｃ_６アルキル（前記アルキルはＡ^１若しくはＢ^２から選択される１個、２個若しくは３個の置換基で置換されていてもよい）、
ｂ）Ａ^１基、
ｃ）水素原子、から独立に選択されるか、
又は
－ Ｒ^８及びＲ^９は、それらが結合している窒素原子とともに、Ｏ及びＮから選択される１個のヘテロ原子を含んでいてもよい、５から６員の複素環を形成するものであり、前記複素環は直鎖若しくは分枝のＣ_１－Ｃ_４アルキルから独立に選択される１若しくは２の基で置換されていてもよく、
－ Ｒ^３は、
ａ）直鎖又は分枝のＣ_１－Ｃ_６アルキル（前記アルキルはハロゲン原子、－Ｎ（Ｒ^６）Ｒ^７及び－ＯＲ^６から選択される１個、２個又は３個の置換基で置換されていてもよい）、
ｂ）Ｃ_３－Ｃ_６シクロアルキル（前記シクロアルキルは１個、２個又は３個のハロゲン原子で置換されていてもよい）、
ｃ）水素原子、
ｄ）－ＮＨ_２、
ｅ）－ＣＮ、から選択される基であり、
－ Ｒ^４は、
ａ）Ａ^１基、
ｂ）直鎖又は分枝のＣ_１－Ｃ_６アルキル（前記アルキルはＡ^１若しくはＢ^２から選択される１個、２個又は３個の置換基で置換されていてもよい）、
ｃ）－Ｎ（Ｒ^６）Ｒ^７、
ｄ）－ＣＮ、
ｅ）－ＣＯ－Ｈ、
ｆ）－ＣＯ－Ｍｅ、及び
ｇ）ＣＯ－ＯＭｅ、
ｈ）水素原子、から選択される基であり、
－ Ｘ^１、Ｘ^２、Ｘ^３、Ｘ^４及びＸ^５は、Ｃ－Ｂ^１、Ｎ及びＣ－Ｈから独立に選択され、
－ Ａ^１は、
ａ）Ｃ_３－Ｃ_６シクロアルキル（前記シクロアルキルの環は＝Ｏ及びＢ^３から選択される１個、２個、３個又は４個の置換基で置換されていてもよい）、
ｂ）Ｏ、Ｓ及びＮから選択される１個、２個又は３個のヘテロ原子を含む３から６員の飽和へテロシクリル環であり（前記環は＝Ｏ及びＢ^３から選択される１個、２個又は３個の置換基で置換されていてもよい）、
ｃ）フェニル基又は５から６員のヘテロアリール基（前記フェニル基又は前記ヘテロアリール基のいずれか一方はＢ^１から選択される１個、２個又は３個の置換基で置換されていてもよい）、から選択され、
－ 各Ｂ^１は、ハロゲン原子、－ＣＦ_３基、５から６員のヘテロアリール、直鎖又は分枝のＣ_１－Ｃ_６アルキル、－ＣＮ、－Ｎ（Ｒ^６）Ｒ^７、－ＯＲ^６、－Ｃ（＝Ｏ）Ｒ^６、－Ｃ（＝Ｏ）ＯＲ^６、－Ｃ（＝Ｏ）Ｎ（Ｒ^６）Ｒ^７、－ＯＣ（＝Ｏ）－Ｒ^６、－Ｎ（Ｒ^６）Ｃ（＝Ｏ）Ｒ^７、－ＮＲ^７ＳＯ_２Ｒ^６、－ＳＯ_２Ｎ（Ｒ^６）Ｒ^７、－ＳＲ^６、－Ｓ（Ｏ）Ｒ^６及び－Ｓ（Ｏ）_２Ｒ^６から独立に選択され、
－ 各Ｂ^２は、ハロゲン原子、－ＣＮ、－Ｎ（Ｒ^６）Ｒ^７、－ＯＲ^６、－Ｃ（＝Ｏ）Ｒ^６、－Ｃ（＝Ｏ）ＯＲ^６、－Ｃ（＝Ｏ）Ｎ（Ｒ^６）Ｒ^７、－ＯＣ（＝Ｏ）－Ｒ^６、－Ｎ（Ｒ^６）Ｃ（＝Ｏ）Ｒ^７、－ＮＲ^７ＳＯ_２Ｒ^６、－ＳＯ_２Ｎ（Ｒ^６）Ｒ^７、－ＳＲ^６、－Ｓ（Ｏ）Ｒ^６、－Ｓ（Ｏ）_２Ｒ^６、及びアルキニル基から独立に選択され、
－ 各Ｂ^３は、ハロゲン原子、直鎖又は分枝のＣ_１－Ｃ_６アルキル、－ＣＮ、－Ｎ（Ｒ^６）Ｒ^７、－ＯＲ^６、－Ｃ（＝Ｏ）Ｒ^６、－Ｃ（＝Ｏ）ＯＲ^６、－Ｃ（＝Ｏ）Ｎ（Ｒ^６）Ｒ^７、－ＯＣ（＝Ｏ）－Ｒ^６、－Ｎ（Ｒ^６）Ｃ（＝Ｏ）Ｒ^７、－ＮＲ^７ＳＯ_２Ｒ^６、－ＳＯ_２Ｎ（Ｒ^６）Ｒ^７、－ＳＲ^６、－Ｓ（Ｏ）Ｒ^６、－Ｓ（Ｏ）_２Ｒ^６から独立に選択され、
各Ｒ^６及びＲ^７は、
－ 水素原子、
－ 直鎖又は分枝のＣ_１－Ｃ_１２アルキル、Ｃ_３－Ｃ_６シクロアルキル、及びＣ_４－Ｃ_６ヘテロシクロアルキル（前記アルキル、前記シクロアルキル、前記ヘテロシクロアルキルは、＝Ｏ（オキソ）、ハロゲン原子、ヒドロキシ、フェニル、Ｃ_３－Ｃ_６シクロアルキル、直鎖若しくは分枝のＣ_１－Ｃ_６アルコキシ、アミノ、アルキルアミノ、ジアルキルアミノ、直鎖若しくは分枝のＣ_１－Ｃ_６アルキルカルボニルから選択される１個、２個又は３個の置換基で置換されていてもよい）、
－ フェニル基又は５から６員のヘテロアリール基（前記フェニル基、前記ヘテロアリール基はハロゲン原子、シアノ基、直鎖若しくは分枝のＣ_１－Ｃ_６アルキル、直鎖若しくは分枝のＣ_１－Ｃ_６ハロアルキル、ヒドロキシ、直鎖若しくは分枝のＣ_１－Ｃ_６アルコキシ、アミノ、アルキルアミノ、ジアルキルアミノから選択される１個、２個、又は３個の置換基で置換されていてもよい）；
－ Ｒ^６及びＲ^７は、それらが結合している窒素原子とともに、Ｏ、Ｎ及びＳから選択されるさらなるヘテロ原子を含んでいてもよい、３から８員の環を形成するものである（前記環は、＝Ｏ（オキソ）、直鎖若しくは分枝のＣ_１－Ｃ_６アルキル、直鎖若しくは分枝のＣ_１－Ｃ_６ハロアルキル、直鎖若しくは分枝のＣ_１－Ｃ_６アルキルカルボニルから選択される１、２又は３個の置換基で置換されていてもよい）、を独立に表し；
－ ただし、Ｒ^１が－ＣＯＯＲ^５であり、Ｒ^２が－ＣＯＯＲ^８である場合は、Ｒ^４はメチル基ではない）
の化合物及びその薬学的に許容される塩。
［２］Ｘ^１、Ｘ^２、Ｘ^３、及びＸ^５は、Ｃ－Ｈ又はＣ－Ｂ^１を表す（式中、Ｂ^１はハロゲン原子を表す）、上記［１］に記載の化合物。
［３］Ｘ^４は、Ｃ－Ｂ^１及びＮから選択される基である、上記［２］に記載の化合物。
［４］Ｂ^１は、－ＣＮ基及びハロゲン原子から選択される、上記［３］に記載の化合物。
［５］Ｒ^１は、－ＣＯＲ^５、－ＣＯＯＲ^５及び－ＣＮ基から選択される基である、上記［２］～[４］のいずれかに記載の化合物。
［６］Ｒ^５は、
－ Ｃ_１－Ｃ_４アルキル（前記アルキルの末端のメチルは、置換されていない又は３個のフッ素原子（－ＣＦ_３）で置換されている）、
－ Ｃ_１－Ｃ_３アルキル（前記アルキルは任意の位置においてアルキニル基で置換されていてもよい）、及び
－ Ｃ_３－Ｃ_５シクロアルキル、から選択される、上記［５］に記載の化合物。
［７］Ｒ^２は、－ＣＯＯＲ^８を表す、上記［２］～[６］のいずれかに記載の化合物。
［８］Ｒ^８は、
－ 直鎖若しくは分枝のＣ_１－Ｃ_６アルキル（前記アルキルはフッ素原子及び１個、２個若しくは３個のフッ素原子で置換されていてもよいＣ_３－Ｃ_５シクロアルキルから選択される、１個、２個、若しくは３個の置換基で置換されていてもよい）、又は
－ Ａ^１基（前記Ａ^１基はフッ素原子及びＣ_１－Ｃ_３アルキル基からなる群から選択される１個、２個若しくは３個の置換基で置換されていてもよいＣ_３－Ｃ_６シクロアルキルを表す）、を独立に表す、上記［７］に記載の化合物。
［９］Ｒ^３は、直鎖又は分枝のＣ_１－Ｃ_４アルキル及びＣ_３－Ｃ_４シクロアルキルから選択される基である（前記基は、１個、２個、又は３個のフッ素原子で置換されていてもよい）、上記［２］～[８］のいずれかに記載の化合物。
［１０］Ｒ^４は、
－ －Ｎ（Ｒ^６）Ｒ^７（式中、Ｒ^６及びＲ^７は水素原子及び直鎖又は分枝のＣ_１－Ｃ_３アルキルから独立に選択される）、
－ Ａ^１基（前記Ａ^１基はＣ_３－Ｃ_６シクロアルキルを表す）、
－ 直鎖又は分枝のＣ_１－Ｃ_３アルキル（前記アルキルは１個、２個若しくは３個のフッ素原子若しくは１個の水酸基から選択される１個、２個又は３個の置換基で置換されていてもよい）、から選択される基である、上記［２］～[９］のいずれかに記載の化合物。
［１１］Ｘ^１、Ｘ^２、Ｘ^３及びＸ^５は－ＣＨを表し、Ｘ^４はＣ－Ｂ^１（式中、Ｂ^１は、－ＣＮ基又は臭素原子を表す）を表し、Ｒ^１は、－Ｃ（Ｏ）ＣＨ_３、－Ｃ（Ｏ）ＯＣＨ_３、－Ｃ（Ｏ）ＯＣＨ_２－アルキニル、及びＣＮから選択される基であり、Ｒ^２は、－Ｃ（Ｏ）Ｏ－直鎖又は分枝のＣ_１－Ｃ_５アルキル基（前記アルキル基は１個、２個又は３個のフッ素原子で置換されていてもよい）及びＣ（Ｏ）ＯＣＨ_２－シクロプロピル（前記シクロプロピルは１個、２個、又は３個のフッ素原子で置換されていてもよい）から選択される基であり、Ｒ^３は、直鎖又は分枝のＣ_１－Ｃ_３アルキル及びＣ_３－Ｃ_４シクロアルキルから選択される基であり、かつ、Ｒ^４は、直鎖又は分枝のＣ_１－Ｃ_３アルキル、Ｃ_３－Ｃ_４シクロアルキル及び－ＮＨ_２から選択される基である、上記［１］に記載の化合物。
［１２］Ｘ^１、Ｘ^２、Ｘ^３及びＸ^５は－ＣＨを表し、Ｘ^４はＣ－Ｂ^１（式中、Ｂ^１は－ＣＮ基を表す）を表し、Ｒ^１は、－Ｃ（Ｏ）ＣＨ_３、－Ｃ（Ｏ）ＯＣＨ_３から選択される基であり、Ｒ^２は、－Ｃ（Ｏ）ＯＣＨ_２－シクロプロピル（前記シクロプロピルは１個、２個、又は３個のフッ素原子で置換されていてもよい）及び－Ｃ（Ｏ）ＯＣＨ_２－ＣＦ_３から選択される基であり、Ｒ^３は、メチル及びシクロプロピルから選択される基であり、かつ、Ｒ^４は、シクロプロピル及び－ＮＨ_２から選択される基である、上記［１］に記載の化合物。
［１３］メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロ－ピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロ－ピリジン－３－カルボキシレート（エナンチオマー１）、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロ－ピリジン－３－カルボキシレート（エナンチオマー２）、
５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキサミド、
１－（４－（ベンゾ［ｂ］チオフェン－３－イル）－５－ベンゾイル－２，６－ジメチル－１，４－ジヒドロピリジン－３－イル）エタン－１－オン、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－フェニル－１，４－ジヒドロピリジン－３－カルボキシレート、
１－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－５－ニコチノイル－１，４－ジヒドロピリジン－３－イル）エタン－１－オン、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロ－［２，３’－ビピリジン］－３－カルボキシレート、
２，２，２－トリフルオロエチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボン酸、
１－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－５－（４－メチルピペラジン－１－カルボニル）－１，４－ジヒドロピリジン－３－イル）エタン－１－オン、
５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－Ｎ，Ｎ－ジエチル－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキサミド、
１－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－５－（モルホリン－４－カルボニル）－１，４－ジヒドロピリジン－３－イル）エタン－１－オン、
２－メトキシエチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－アセトアミドプロピル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ベンジル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロ－ピリジン－３－カルボキシレート、
２－モルホリノエチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
２－（ジメチルアミノ）エチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
２－アセトアミドエチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－（メトキシメチル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－（（ジメチルアミノ）メチル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４－メトキシベンジル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－２－イルメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－（モルホリノ－メチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ビス（モルホリノメチル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
２－ヒドロキシエチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
１－（４－（ベンゾ［ｂ］チオフェン－３－イル）－５－（シクロプロパンカルボニル）－６－シクロプロピル－２－メチル－１，４－ジヒドロピリジン－３－イル）エタン－１－オン、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－（１－（ｔｅｒｔ－ブトキシカルボニル）アゼチジン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
（１－（ｔｅｒｔ－ブトキシカルボニル）ピペリジン－４－イル）メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシルメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－５－（シクロプロパンカルボニル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３－カルボキシレート、
５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－Ｎ－フェニル－１，４－ジヒドロピリジン－３－カルボキサミド、
テトラヒドロ－２Ｈ－ピラン－４－イル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
（テトラヒドロ－２Ｈ－ピラン－４－イル）メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－（２－メトキシ－２－オキソエチル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２，６－ジメチル－４－（２－メチルベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－（２－メトキシエチル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－（（ベンジルオキシ）メチル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－（フェノキシメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
フェネチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－５－（シクロプロパンカルボニル）－６－シクロプロピル－２－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－ベンジル－２－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－５－（２－フェニルアセチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－５－（２－メトキシアセチル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－（メトキシメチル）－２－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－（フルオロメチル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ５－アセチル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
１－（ｔｅｒｔ－ブトキシカルボニル）ピペリジン－４－イル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロペンチルメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
１－メチルピペリジン－４－イル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロペンチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４，４－ジメチルシクロヘキシル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロブチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２，６－ジメチル－４－（チエノ［３，２－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－メチル－６－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシルメチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロペンチルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロペンチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
（テトラヒドロ－２Ｈ－ピラン－４－イル）メチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ベンジル ５－アセチル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ベンジル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
（テトラヒドロ－２Ｈ－ピラン－４－イル）メチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
（テトラヒドロ－２Ｈ－ピラン－４－イル）メチル ５－アセチル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ベンジル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４－フルオロベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－３－イルメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
１，１’－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２－ベンジル－６－メチル－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１－（５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－イル）－２－フェニルエタン－１－オン、
メチル ５－アセチル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－２－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
１－（２－メチル－５－（ピペリジン－１－カルボニル）－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－６－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－イル）エタン－１－オン、
４－（（（５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロ－ピリジン－３－カルボニル）オキシ）メチル）安息香酸、
ベンジル ５－アセチル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－２－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－３－イルメチル ５－アセチル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－３－イルメチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－３－イルメチル ５－アセチル－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－３－イルメチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－３－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４－（シクロプロピルカルバモイル）ベンジル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４ジヒドロピリジン－３－カルボキシレート、
４－ブロモベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
３－ブロモベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－ブロモベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
（３－フルオロピリジン－４－イル）メチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリミジン－５－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
（５－ブロモピリジン－３－イル）メチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－フェニルプロパン－２－イル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
３－シアノベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
４－シアノベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
（６－クロロピリジン－３－イル）メチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
３－モルホリノベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
４，４－ジメチルシクロヘキシル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
（２－クロロピリジン－４－イル）メチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
テトラヒドロ－２Ｈ－ピラン－４－イル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
４，４－ジフルオロシクロヘキシル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
５－アセチル－Ｎ－ベンジル－Ｎ，２，６－トリメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキサミド、
オキセタン－３－イル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
イソプロピル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－６－メチル－２－（トリフルオロメチル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－シクロプロピル－６－メチル－４－（７－（２，２，２－トリフルオロアセチル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－フェニルプロパン－２－イル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－アミノ－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ２－アミノ－４－（ベンゾ［ｂ］チオフェン－３－イル）－５－（シクロプロパンカルボニル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－アミノ－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－アミノ－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロペンチル ５－アセチル－２－アミノ－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート
シクロペンチル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ２，６－ジアミノ－４－（ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
シクロプロピルメチル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４，４－ジフルオロシクロヘキシル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ２－アミノ－５－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４－フルオロベンジル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－アミノ－４－（５－フルオロチエノ［２，３－ｂ］ピリジン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ２－アセトアミド－５－アセチル－４－（５－フルオロチエノ［２，３－ｂ］ピリジン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロペンチルメチル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ジメチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－シクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－シクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ジメチル ２，６－ジアミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
５－（シクロプロピルメチル）３－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－シクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（４－フルオロベンジル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（４－フルオロベンジル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－シクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
シクロプロピルメチル ２－アミノ－５－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４－フルオロベンジル ２－アミノ－５－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ６－アミノ－５－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－シクロペンチル５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
シクロプロピルメチル ５－アセチル－２－アミノ－４－（６－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシルメチル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－５－（シクロプロパンカルボニル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－フルオロベンジル ５－アセチル－２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（シクロブチルメチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（（３，３－ジフルオロシクロブチル）メチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
シクロプロピルメチル ２－アミノ－５－カルバモイル－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（（２，２－ジフルオロシクロプロピル）メチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
５－シクロプロピル ３－（シクロプロピルメチル）２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（（２，２－ジフルオロシクロプロピル）メチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－シクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（７－シアノ－５－フルオロベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（７－シアノ－４－フルオロベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－イソプロピル ５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（（２，２－ジフルオロ－３，３－ジメチルシクロプロピル）メチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
５－メチル ３－ネオペンチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（７－シアノチエノ［３，２－ｂ］ピリジン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
５－メチル ３－ネオペンチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－シクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ビス（シクロプロピルメチル）２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－（プロパ－２－イン－１－イル）２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（５，７－ジシアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
５－（ブタ－２－イン－１－イル）３－（シクロプロピルメチル）２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
５－メチル ３－（２，２，２－トリフルオロエチル）２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－（２，２，２－トリフルオロエチル）２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（６－クロロ－７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（２－フルオロ－２－メチルプロピル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（７－シアノ－６－（トリフルオロメチル）ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
５－メチル ３－プロパ－２－イン－１－イル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ２－アミノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－（トリフルオロメチル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジカルボニトリル、
４－（６－ヒドロキシベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジカルボニトリル、
４－（６－メトキシベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジカルボニトリル、
２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボニトリル、
４－（ベンゾ［ｂ］チオフェン－３－イル）－２－メチル－６－フェニル－１，４－ジヒドロピリジン－３，５－ジカルボニトリル、
４－（ベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボニトリル、
５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボニトリル、
エチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－５－シアノ－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
エチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－５－シアノ－２－メチル－６－フェニル－１，４－ジヒドロピリジン－３－カルボキシレート、
エチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－５－シアノ－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－５－シアノ－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
１，１’－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジイル）ジエタノン、
１，１’－（４－（６－ヒドロキシベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（４－（６－メトキシベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジイル）ジエタノン、
１，１’－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３，５－ジイル）ジエタノン、
１，１’－（４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジイル）ジエタノン、
１，１’－（４－（５－ブロモベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジイル）ジエタノン、
１，１’－（４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（２，６－ジメチル－４－（５－モルホリノベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（２，６－ジメチル－４－（５－（４－メチルピペラジン－１－イル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（４－（５－（ベンジルアミノ）ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
３－（３，５－ジアセチル－２，６－ジメチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－５－カルボニトリル、
３－（３，５－ジアセチル－２，６－ジメチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－５－カルボン酸、
Ｎ－シクロプロピル－３－（３，５－ジアセチル－２，６－ジメチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－５－カルボキサミド、
Ｎ－（シクロプロピルメチル）－３－（３，５－ジアセチル－２，６－ジメチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－５－カルボキサミド、
１，１’－（２，６－ジメチル－４－（５－（４－メチルピペラジン－１－カルボニル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（２，６－ジメチル－４－（５－（モルホリン－４－カルボニル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（２，６－ジメチル－４－（チエノ［３，２－ｃ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（２，６－ジメチル－４－（チエノ［２，３－ｃ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
１，１’－（２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジイル）ビス（エタン－１－オン）、
ジメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－２，３－ジカルボキシレート、
ジメチル ５－アセチル－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－２，３－ジカルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
エチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
１，１’－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロ－ピリジン－３，５－ジイル）ジエタノン、
１－（４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－５－（メチルスルホニル）－１，４－ジヒドロ－ピリジン－３－イル）エタノン、
メチル ５－アセチル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（５－ブロモベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（５－シアノベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（３－アセチル－５－（メトキシカルボニル）－２，６－ジメチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－５－カルボン酸、
メチル ５－アセチル－４－（５－（シクロプロピルカルバモイル）ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（５－（（シクロプロピルメチル）カルバモイル）ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２，６－ジメチル－４－（５－（４－メチルピペラジン－１－カルボニル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２，６－ジメチル－４－（５－（モルホリン－４－カルボニル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２，６－ジメチル－４－（チエノ［３，２－ｃ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｃ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－シクロプロピル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ２，６－ジシクロプロピル－４－（５－フルオロベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
メチル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ２，６－ジシクロプロピル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
メチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
メチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－シクロプロピル－４－（７－（シクロプロピルカルバモイル）ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
メチル ５－アセチル－２－シクロプロピル－４－（７－（メトキシカルボニル）ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ２，６－ジシクロプロピル－４－（７－（メトキシカルボニル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（３－アセチル－６－シクロプロピル－５－（メトキシカルボニル）－２－メチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－７－カルボン酸、
ベンジル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－４－（ベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ビス（ピリジン－４－イルメチル）２，６－ジシクロプロピル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ピリジン－４－イルメチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－４－（５－クロロベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ピリジン－４－イルメチル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ベンジル ５－アセチル－２－シクロプロピル－４－（７－（メトキシカルボニル）ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジベンジル ２，６－ジシクロプロピル－４－（７－（メトキシカルボニル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ベンジル ５－アセチル－４－（７－（メトキシカルボニル）ベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ３－（３，５－ジアセチル－２，６－ジメチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－７－カルボキシレート、
３－（３，５－ジアセチル－２，６－ジメチル－１，４－ジヒドロピリジン－４－イル）ベンゾ［ｂ］チオフェン－７－カルボニトリル、
ピリジン－４－イルメチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
４－フルオロベンジル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
ビス（４－フルオロベンジル）２，６－ジシクロプロピル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
４－シアノベンジル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（７－クロロベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－シクロプロピル－６－メチル－４－（７－（トリフルオロメチル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
３－クロロベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－フェニルプロパン－２－イル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロヘキシル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－フェニルプロパン－２－イル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
１－（４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－５－（シクロプロパンカルボニル）－６－シクロプロピル－２－メチル－１，４－ジヒドロピリジン－３－イル）エタン－１－オン、
３－クロロベンジル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－（４－フルオロフェニル）プロパン－２－イル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－（４－フルオロフェニル）プロパン－２－イル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
２－（４－フルオロフェニル）プロパン－２－イル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－シクロプロピル－４－（７－フルオロベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロペンチル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ５－アセチル－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロブチル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
メチル ５－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロペンチル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２－シクロヘキシル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（（４－メチルピペラジン－１－イル）メチル）ベンジル ５－アセチル－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－２，６－ジメチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（シクロプロピルメチル）５－メチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
３－（シクロプロピルメチル）５－メチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２，６－ジシクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
シクロプロピルメチル ５－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ２－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－シクロプロピル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ジメチル ２－シアノ－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
メチル ５－アセチル－２－（（２－アミノエトキシ）メチル）－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－（（２－アミノエトキシ）メチル）－４－（７－ブロモベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－（（２－アミノエトキシ）メチル）－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
ジメチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－ホルミル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ジメチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－（ヒドロキシメチル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ジメチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－ホルミル－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ジメチル ４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－２－（ヒドロキシメチル）－６－メチル－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
ジメチル ２－シアノ－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３，５－ジカルボキシレート、
シクロプロピルメチル ５－アセチル－４－（６－シアノベンゾ［ｂ］チオフェン－３－イル）－２－シクロプロピル－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
シクロプロピルメチル ２，５－ジアセチル－４－（７－シアノベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－アミノ－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート塩酸塩、
メチル ５－アセチル－２－アミノ－４－（ベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレートトリフルオロメタンスルホン酸塩、
４－（ピリジン－４－イル）ベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
４－（ピリジン－３－イル）ベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（ピリジン－４－イル）ベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（ピリジン－３－イル）ベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－（ピリジン－４－イル）ベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
２－（ピリジン－３－イル）ベンジル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
［３，４’－ビピリジン］－５－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
［３，３’－ビピリジン］－５－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
［２，４’－ビピリジン］－５－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
［２，３’－ビピリジン］－５－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
［２，３’－ビピリジン］－４－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
［２，４’－ビピリジン］－４－イルメチル ５－アセチル－２，６－ジメチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－シクロプロピル－６－メチル－４－（７－（ピリジン－４－イル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
メチル ５－アセチル－２－シクロプロピル－４－（７－シクロプロピルベンゾ［ｂ］チオフェン－３－イル）－６－メチル－１，４－ジヒドロピリジン－３－カルボキシレート、
３－（ピリジン－４－イル）ベンジル ５－アセチル－２－シクロプロピル－６－メチル－４－（チエノ［２，３－ｂ］ピリジン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、
１，１’－（２，６－ジメチル－４－（５－（ピリジン－３－イル）ベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロ－ピリジン－３，５－ジイル）ジエタノン、
メチル ５－アセチル－２－シクロプロピル－６－メチル－４－（７－フェニルベンゾ［ｂ］チオフェン－３－イル）－１，４－ジヒドロピリジン－３－カルボキシレート、からなる群から選択される、上記［１］に記載の化合物。
［１４］アンドロゲン受容体及び／又はグルココルチコイド受容体の拮抗作用による改善に感受性のある疾患又は病状の治療において使用するための上記［１］～[１３］のいずれかに記載の化合物。
［１５］アンドロゲン受容体及び／又はグルココルチコイド受容体の拮抗作用による改善に感受性のある疾患又は病状は、前立腺癌、去勢抵抗性前立腺癌、膵癌、膀胱癌、腎癌、胃癌、肺癌、乳癌、結腸癌、結腸直腸癌、卵巣癌、及び他の固形腫瘍、メラノーマ、転移性癌、良性前立腺肥大、多嚢胞性卵巣症候群（ＰＣＯＳ）、脱毛、多毛症、ざ瘡、性腺機能低下症、筋肉消耗疾患及び悪液質、及びクッシング症候群、抗精神薬誘発性体重増加、肥満、外傷後ストレス障害、及びアルコール依存症から選択される、上記［１４］に記載の使用のための化合物。
［１６］上記［１］～[１３］のいずれかに記載の化合物及び薬学的に許容される希釈剤又はキャリアを含む、医薬組成物。
［１７］前立腺癌、去勢抵抗性前立腺癌、膵癌、膀胱癌、腎癌、胃癌、肺癌、乳癌、結腸癌、結腸直腸癌、卵巣癌、及び他の固形腫瘍、メラノーマ、転移性癌、良性前立腺肥大、多嚢胞性卵巣症候群（ＰＣＯＳ）、脱毛、多毛症、ざ瘡、性腺機能低下症、筋肉消耗疾患及び悪液質、及びクッシング症候群、向精神薬誘発性体重増加、肥満、外傷後ストレス障害、及びアルコール依存症、を治療するための薬剤から選択される治療有効量の治療薬をさらに含む、上記［１６］に記載の医薬組成物。
［１８］上記［１］～[１３］のいずれかに記載の化合物、並びに、前立腺癌、去勢抵抗性前立腺癌、膵癌、膀胱癌、腎癌、胃癌、肺癌、乳癌、結腸癌、結腸直腸癌、卵巣癌、及び他の固形腫瘍、メラノーマ、転移性癌、良性前立腺肥大、多嚢胞性卵巣症候群（ＰＣＯＳ）、脱毛、多毛症、ざ瘡、性腺機能低下症、筋肉消耗疾患及び悪液質、及びクッシング症候群、抗精神薬誘発性体重増加、肥満、外傷後ストレス障害、及びアルコール依存症、を治療するために用いられる治療薬、を含む組合せ製品。
［１９］前記治療薬は、ゴナドトロピン放出ホルモン（ＧｎＲＨ）受容体のアゴニスト又はアンタゴニスト、アンドロゲン受容体アンタゴニスト、ＣＹＰ１７阻害剤、ＶＥＧＦ阻害剤、ＥＧＦＲ阻害剤、ＰＩ３Ｋ阻害剤、ＡＫＴ阻害剤、ｍＴＯＲ阻害剤、ｃ－Ｍｅｔ阻害剤、Ｓｒｃ阻害剤、ＰＡＲＰ阻害剤、アンジオポエチン、ＡＬＫ阻害剤、ＲＯＳ－１阻害剤、抗－（ＩＧＦ）抗体、タキサン抗悪性腫瘍薬、トポイソメラーゼＩＩ阻害剤、抗腫瘍抗生物質、ＨＳＰ９０阻害剤、オーロラキナーゼ阻害剤、ＰＳＡ指向性ワクチン、ＧＲアンタゴニスト、１１－ベータＨＳＤ阻害剤、抗ＣＴＬＡ４抗体、抗ＰＤ１抗体及び抗ＰＤＬ１抗体からなる群から選択される１以上の免疫療法薬、から選択される、上記［１８］に記載の組合せ製品。
［２０］免疫療法薬は、イピリムマブ、トレメリムマブ、ニボルマブ、ペムブロリズマブ、ＣＴ－０１１、ＡＭＰ－２２４、ＭＰＤＬ３２８０Ａ、ＭＥＤＩ４７３６及びＭＤＸ－１１０５からなる群から選択される、上記［１９］に記載の組合せ製品。
［２１］アンドロゲン受容体及び／又はグルココルチコイド受容体の拮抗作用による改善に感受性のある疾患又は病状の治療用の医薬を製造するための上記［１］～[１３］のいずれかに記載の化合物の使用。
［２２］アンドロゲン受容体及び／又はグルココルチコイド受容体の拮抗作用による改善に感受性のある疾患又は病状は、前立腺癌、去勢抵抗性前立腺癌、膵癌、膀胱癌、腎癌、胃癌、肺癌、乳癌、結腸癌、結腸直腸癌、卵巣癌、及び他の固形腫瘍、メラノーマ、転移性癌、良性前立腺肥大、多嚢胞性卵巣症候群（ＰＣＯＳ）、脱毛、多毛症、ざ瘡、性腺機能低下症、筋肉消耗疾患及び悪液質、及びクッシング症候群、抗精神薬誘発性体重増加、肥満、外傷後ストレス障害、及びアルコール依存症から選択される、上記［２１］に記載の使用。
［２３］上記［１］～[１３］のいずれかに記載の化合物を必要とする対象に投与することを含む、アンドロゲン受容体及び／又はグルココルチコイド受容体の拮抗作用による改善に感受性のある疾患又は病状の治療方法。
［２４］アンドロゲン受容体及び／又はグルココルチコイド受容体の拮抗作用による改善に感受性のある疾患又は病状は、前立腺癌、去勢抵抗性前立腺癌、膵癌、膀胱癌、腎癌、胃癌、肺癌、乳癌、結腸癌、結腸直腸癌、卵巣癌、及び他の固形腫瘍、メラノーマ、転移性癌、良性前立腺肥大、多嚢胞性卵巣症候群（ＰＣＯＳ）、脱毛、多毛症、ざ瘡、性腺機能低下症、筋肉消耗疾患及び悪液質、及びクッシング症候群、抗精神薬誘発性体重増加、肥満、外傷後ストレス障害、及びアルコール依存症から選択される、上記［２３］に記載の方法。
本発明について、以下の実施例でさらに説明する。以下は、説明として与えるものであり、決してこの発明の範囲を限定しない。この発明の化合物の合成は、中間体の調製を含めて、以下の実施例により説明されるが、これは、本発明の範囲を決して限定しない。 The present invention is as follows.
[1] the following general formula (I):

(In the formula,
- R ¹ is
a) ^-COR5 ,
b) ^-COOR5 ,
c) -CN,
d) a group selected from —C(O)NH ₂ ;
- ^R5 is
a) linear or branched C ₁ -C ₆ alkyl, wherein said alkyl is one selected from —N(R ⁶ )R ⁷ and —OR ⁶ , halogen atoms, C ₃ -C ₆ cycloalkyl and alkynyl groups; , optionally substituted with 2 or 3 substituents),
b) a group selected from C ₃ -C ₆ cycloalkyl;
- ^R2 is
a) -COOR ⁸ ,
b) ^-COR8 ,
c) —C(O)N(R ⁸ )R ⁹ ,
d) -CN,
e) a group selected from —S(O) _n R ⁸ (n is an integer of 1 to 2),
- R ⁸ and R ⁹ are
a) linear or branched C ₁ -C ₆ alkyl (said alkyl optionally substituted with 1, 2 or 3 substituents selected from A ¹ or B ² ),
b) ¹ group A,
c) hydrogen atoms, or
or - R ⁸ and R ⁹ together with the nitrogen atom to which they are attached form a 5- to 6-membered heterocyclic ring optionally containing one heteroatom selected from O and N; and said heterocyclic ring is optionally substituted with 1 or 2 groups independently selected from linear or branched C ₁ -C ₄ alkyl,
- ^R3 is
a) linear or branched C ₁ -C ₆ alkyl, said alkyl substituted with 1, 2 or 3 substituents selected from halogen atoms, —N(R ⁶ )R ⁷ and —OR ⁶ may have been),
b) C ₃ -C ₆ cycloalkyl, said cycloalkyl optionally substituted by 1, 2 or 3 halogen atoms,
c) a hydrogen atom,
d) —NH ₂ ,
e) a group selected from —CN,
- ^R4 is
a) ¹ group A,
b) linear or branched C ₁ -C ₆ alkyl (said alkyl optionally substituted with 1, 2 or 3 substituents selected from A ¹ or B ² ),
c) —N(R ⁶ )R ⁷ ,
d) -CN,
e) -CO-H,
f) —CO—Me, and g) CO—OMe,
h) a hydrogen atom, and
- X ¹ , X ² , X ³ , X ⁴ and X ⁵ are independently selected from CB ¹ , N and C-H;
- A ¹ is
a) C ₃ -C ₆ cycloalkyl (wherein said cycloalkyl ring is optionally substituted with 1, 2, 3 or 4 substituents selected from ═O and B ³ ),
b) a 3- to 6-membered saturated heterocyclyl ring containing 1, 2 or 3 heteroatoms selected from O, S and N, wherein said ring has 1 selected from =O and B ³ , optionally substituted with 2 or 3 substituents),
c) a phenyl group or a 5- to 6-membered heteroaryl group (either the phenyl group or the heteroaryl group may be substituted with 1, 2 or 3 substituents selected from B ¹ good), selected from
- each B ¹ is a halogen atom, -CF ₃ group, 5- to 6-membered heteroaryl, linear or branched C ₁ -C ₆ alkyl, -CN, -N(R ⁶ )R ⁷ , -OR ⁶ , -C(=O)R ⁶ , -C(=O)OR ⁶ , -C(=O)N(R ⁶ )R ⁷ , -OC(=O)-R ⁶ , -N(R ⁶ )C independently selected from (=O)R ⁷ , —NR ⁷ SO ₂ R ⁶ , —SO ₂ N(R ⁶ )R ⁷ , —SR ⁶ , —S(O)R ⁶ and —S(O) ₂ R ⁶ is,
- each B ² is a halogen atom, -CN, -N(R ⁶ )R , -OR ⁶ , -C(=O)R ⁶ , -C(=O) ^{OR 6 ,} -C(=O)N (R ⁶ )R ⁷ , —OC(=O)—R ⁶ , —N(R ⁶ )C(=O)R ⁷ , —NR ⁷ SO ₂ R ⁶ , —SO ₂ N(R ⁶ )R ⁷ , independently selected from —SR ⁶ , —S(O)R ⁶ , —S(O) ₂ R ⁶ , and an alkynyl group;
- each B ³ is a halogen atom, linear or branched C ₁ -C ₆ alkyl, -CN, -N(R ⁶ )R ⁷ , -OR ⁶ , -C(=O)R ⁶ , -C( =O)OR ⁶ , -C(=O)N(R ⁶ )R ⁷ , -OC(=O)-R ⁶ , -N(R ⁶ )C(=O)R ⁷ , -NR ⁷ SO ₂ R ⁶ , —SO ₂ N(R ⁶ )R ⁷ , —SR ⁶ , —S(O)R ⁶ , —S(O) ₂ R ⁶ ,
Each ^R6 and ^R7 is
- hydrogen atoms,
- linear or branched C ₁ -C ₁₂ alkyl, C ₃ -C ₆ cycloalkyl and C ₄ -C ₆ heterocycloalkyl (said alkyl, said cycloalkyl, said heterocycloalkyl are ═O(oxo) , halogen atom, hydroxy, phenyl, C ₃ -C ₆ cycloalkyl, linear or branched C ₁ -C ₆ alkoxy, amino, alkylamino, dialkylamino, linear or branched C ₁ -C ₆ alkylcarbonyl optionally substituted with 1, 2 or 3 substituents selected from
- a phenyl group or a 5- to 6-membered heteroaryl group (said phenyl group, said heteroaryl group being a halogen atom, a cyano group, a linear or branched C ₁ -C ₆ alkyl, a linear or branched C ₁ - optionally substituted with 1, 2 or 3 substituents selected from C ₆ haloalkyl, hydroxy, linear or branched C ₁ -C ₆ alkoxy, amino, alkylamino, dialkylamino) ;
- R ⁶ and R ⁷ together with the nitrogen atom to which they are attached form a 3- to 8-membered ring which may contain further heteroatoms selected from O, N and S ( Said ring is from =O (oxo), linear or branched C ₁ -C ₆ alkyl, linear or branched C ₁ -C ₆ haloalkyl, linear or branched C ₁ -C ₆ alkylcarbonyl independently substituted with 1, 2 or 3 selected substituents;
- provided that when R ¹ is -COOR ⁵ and R ² is -COOR ⁸ , R ⁴ is not a methyl group)
and pharmaceutically acceptable salts thereof.
[2] The compound according to [1] above, wherein X ¹ , X ² , X ³ and X ⁵ represent CH or C-B ^{1 (wherein B 1 represents} a halogen atom).
[3] The compound according to [2] above, wherein X ⁴ is a group selected from C—B ¹ and N.
[4] The compound according to [3] above, wherein B ¹ is selected from a —CN group and a halogen atom.
[5] The compound according to any one of [2] to [4] above, wherein R ¹ is a group selected from —COR ⁵ , —COOR ⁵ and —CN groups.
[ ⁶ ] R5 is
- C ₁ -C ₄ alkyl, wherein the terminal methyl of said alkyl is unsubstituted or substituted with 3 fluorine atoms (-CF ₃ ),
- C ₁ -C ₃ alkyl (said alkyl may be substituted at any position with an alkynyl group), and - C ₃ -C ₅ cycloalkyl, the compound according to [5] above.
[7] The compound according to any one of [2] to [6] above, wherein R ² represents —COOR ⁸ .
[ ⁸ ] R8 is
- linear or branched C ₁ -C ₆ alkyl, said alkyl being selected from fluorine atoms and C ₃ -C ₅ cycloalkyl optionally substituted by 1, 2 or 3 fluorine atoms, optionally substituted with 1, 2, or 3 substituents), or -A ¹ group, wherein said A ¹ group is 1 selected from the group consisting of a fluorine atom and a C ₁ -C ₃ alkyl group The compound according to [7] above, which independently represents C ₃ -C ₆ cycloalkyl optionally substituted with 1, 2 or 3 substituents.
[9] R ³ is a group selected from linear or branched C ₁ -C ₄ alkyl and C ₃ -C ₄ cycloalkyl, said group containing 1, 2 or 3 fluorine atom), the compound according to any one of the above [2] to [8].
[10] ^R4 is
— —N(R ⁶ )R ⁷ (wherein R ⁶ and R ⁷ are independently selected from a hydrogen atom and linear or branched C ₁ -C ₃ alkyl),
- A ¹ group, said A ¹ group representing C ₃ -C ₆ cycloalkyl,
- linear or branched C ₁ -C ₃ alkyl, wherein said alkyl is substituted with 1, 2 or 3 substituents selected from 1, 2 or 3 fluorine atoms or 1 hydroxyl group The compound according to any one of [2] to [9] above, which is a group selected from
[11] X ¹ , X ² , X ³ and X ⁵ represent —CH, X ⁴ represents C—B ¹ (wherein B ¹ represents a —CN group or a bromine atom), and R ¹ , —C(O)CH ₃ , —C(O)OCH ₃ , —C(O)OCH ₂ -alkynyl, and CN, and R ² is —C(O)O—linear or a branched C ₁ -C ₅ alkyl group (said alkyl group optionally substituted with 1, 2 or 3 fluorine atoms) and C(O)OCH ₂ -cyclopropyl (said cyclopropyl is optionally substituted with 1, 2 or 3 fluorine atoms, and R ³ is linear or branched C ₁ -C ₃ alkyl and C ₃ -C ₄ a group selected from cycloalkyl, and R ⁴ is a group selected from linear or branched C ₁ -C ₃ alkyl, C ₃ -C ₄ cycloalkyl and —NH ₂ [ 1].
[12] X ¹ , X ² , X ³ and X ⁵ represent —CH, X ⁴ represents C—B ¹ (wherein B ¹ represents a —CN group), R ¹ represents —C ( O)CH ₃ , —C(O)OCH ₃ , and R ² is —C(O)OCH ₂ -cyclopropyl, wherein cyclopropyl contains 1, 2 or 3 fluorines; and -C(O)OCH ₂ -CF ₃ , R ³ is a group selected from methyl and cyclopropyl, and R ⁴ is The compound according to [1] above, which is a group selected from cyclopropyl and —NH ₂ .
[13] methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 1),
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 2),
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-5-benzoyl-2,6-dimethyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-phenyl-1,4-dihydropyridine-3-carboxylate,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-nicotinoyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydro-[2,3′-bipyridine]-3-carboxylate,
2,2,2-trifluoroethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(4-methylpiperazine-1-carbonyl)-1,4-dihydropyridin-3-yl)ethane-1- on,
5-acetyl-4-(benzo[b]thiophen-3-yl)-N,N-diethyl-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(morpholine-4-carbonyl)-1,4-dihydropyridin-3-yl)ethan-1-one,
2-methoxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-acetamidopropyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
2-morpholinoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-(dimethylamino)ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-acetamidoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(methoxymethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((dimethylamino)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-methoxybenzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-2-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(morpholino-methyl)-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(benzo[b]thiophen-3-yl)-2,6-bis(morpholinomethyl)-1,4-dihydropyridine-3,5-dicarboxylate,
2-hydroxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethan-1-one,
Methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(1-(tert-butoxycarbonyl)azetidin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxy rate,
(1-(tert-butoxycarbonyl)piperidin-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate ,
cyclohexylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-N-phenyl-1,4-dihydropyridine-3-carboxamide,
tetrahydro-2H-pyran-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxy-2-oxoethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(2-methylbenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxyethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((benzyloxy)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(phenoxymethyl)-1,4-dihydropyridine-3-carboxylate,
phenethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-benzyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(2-phenylacetyl)-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(2-methoxyacetyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-(methoxymethyl)-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(fluoromethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(tert-butoxycarbonyl)piperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-methylpiperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclobutyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[3,2-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-6-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(Tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
benzyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-benzyl-6-methyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1-(5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3-yl)-2-phenylethan-1-one,
methyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
1-(2-methyl-5-(piperidine-1-carbonyl)-4-(thieno[2,3-b]pyridin-3-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3 -yl) ethane-1-one,
4-(((5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carbonyl)oxy)methyl)benzoic acid,
benzyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-(cyclopropylcarbamoyl)benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4 dihydropyridine-3-carboxylate,
4-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(3-fluoropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyrimidin-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(5-bromopyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(6-chloropyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-morpholinobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(2-chloropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
tetrahydro-2H-pyran-4-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
5-acetyl-N-benzyl-N,2,6-trimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxamide,
oxetane-3-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
isopropyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
Methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(2,2,2-trifluoroacetyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
Dimethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Cyclopentyl 5-acetyl-2-amino-4-( 7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-diamino-4-(benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-acetamido-5-acetyl-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2,6-diamino-4-(7-cyanobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
5-(cyclopropylmethyl)3-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(4-fluorobenzyl) 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(4-fluorobenzyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 6-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-1,4-dihydropyridine-3-carboxylate,
3-cyclopentyl 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-2-amino-4-(6-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-fluorobenzyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(cyclobutylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((3,3-difluorocyclobutyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5 - a dicarboxylate,
cyclopropylmethyl 2-amino-5-carbamoyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-((2,2-difluorocyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5 - a dicarboxylate,
5-cyclopropyl 3-(cyclopropylmethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((2,2-difluorocyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3, 5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-4-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-isopropyl 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((2,2-difluoro-3,3-dimethylcyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4 - dihydropyridine-3,5-dicarboxylate,
5-methyl 3-neopentyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanothieno[3,2-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
5-methyl 3-neopentyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
bis(cyclopropylmethyl) 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-(prop-2-yn-1-yl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(5,7-dicyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate ,
5-(but-2-yn-1-yl)3-(cyclopropylmethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
5-methyl 3-(2,2,2-trifluoroethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5- dicarboxylate,
3-(Cyclopropylmethyl)5-(2,2,2-trifluoroethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(6-chloro-7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
3-(2-fluoro-2-methylpropyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-6-(trifluoromethyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3 , 5-dicarboxylate,
5-methyl 3-prop-2-yn-1-yl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarboxy rate,
4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-methyl-6-phenyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarbonitrile,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carbonitrile,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-methyl-6-phenyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-morpholinobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazin-1-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(4-(5-(benzylamino)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)bis(ethane-1- on),
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carbonitrile,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
N-cyclopropyl-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
N-(cyclopropylmethyl)-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethane -1-on),
1,1′-(2,6-dimethyl-4-(thieno[3,2-c]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
1,1′-(2,6-dimethyl-4-(thieno[2,3-c]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
1,1′-(2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
dimethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-2,3-dicarboxylate,
dimethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-2,3-dicarboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydro-pyridine-3,5-diyl)diethanone,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(methylsulfonyl)-1,4-dihydro-pyridin-3-yl)ethanone,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-(3-acetyl-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
methyl 5-acetyl-4-(5-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-((cyclopropylmethyl)carbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[3,2-c]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-c]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(5-fluorobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
3-(3-acetyl-6-cyclopropyl-5-(methoxycarbonyl)-2-methyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylic acid,
benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
bis(pyridin-4-ylmethyl) 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dibenzyl 2,6-dicyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
benzyl 5-acetyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylate,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carbonitrile,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
bis(4-fluorobenzyl) 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
4-cyanobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(trifluoromethyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-chlorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-(4-(7-bromobenzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethane-1- on,
3-chlorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3- carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine- 3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclobutyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopentyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclohexyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
3-((4-methylpiperazin-1-yl)methyl)benzyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3- carboxylate,
3-(cyclopropylmethyl)5-methyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7- cyanobenzo [b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-formyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-(hydroxymethyl)-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-formyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-cyano-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-4-(6-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 2,5-diacetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate hydrochloride,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate trifluoromethanesulfonate,
4-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
[3,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[3,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(pyridin-4-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-cyclopropylbenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-4-yl)benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
1,1′-(2,6-dimethyl-4-(5-(pyridin-3-yl)benzo[b]thiophen-3-yl)-1,4-dihydro-pyridine-3,5-diyl)diethanone ,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-phenylbenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate, The compound described in [1] above.
[14] A compound according to any one of [1] to [13] above for use in the treatment of a disease or condition susceptible to amelioration by antagonism of the androgen receptor and/or the glucocorticoid receptor.
[15] Diseases or conditions susceptible to amelioration by androgen receptor and/or glucocorticoid receptor antagonism include prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, stomach cancer, lung cancer, breast cancer, Colon cancer, colorectal cancer, ovarian cancer, and other solid tumors, melanoma, metastatic cancer, benign prostatic hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting A compound for use according to [14] above, selected from disease and cachexia, and Cushing's syndrome, antipsychotic-induced weight gain, obesity, post-traumatic stress disorder, and alcoholism.
[16] A pharmaceutical composition comprising the compound according to any one of [1] to [13] above and a pharmaceutically acceptable diluent or carrier.
[17] Prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, stomach cancer, lung cancer, breast cancer, colon cancer, colorectal cancer, ovarian cancer, and other solid tumors, melanoma, metastatic cancer, benign prostate Hypertrophy, polycystic ovarian syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting disorders and cachexia, and Cushing's syndrome, psychotropic drug-induced weight gain, obesity, post-traumatic stress disorder and alcoholism, further comprising a therapeutically effective amount of a therapeutic agent selected from drugs for treating alcoholism.
[18] The compound according to any one of [1] to [13] above, and prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, stomach cancer, lung cancer, breast cancer, colon cancer, colorectal cancer , ovarian cancer and other solid tumors, melanoma, metastatic cancer, benign prostatic hyperplasia, polycystic ovarian syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting disease and cachexia, and therapeutic agents used to treat Cushing's syndrome, antipsychotic-induced weight gain, obesity, post-traumatic stress disorder, and alcoholism.
[19] The therapeutic agent is a gonadotropin-releasing hormone (GnRH) receptor agonist or antagonist, androgen receptor antagonist, CYP17 inhibitor, VEGF inhibitor, EGFR inhibitor, PI3K inhibitor, AKT inhibitor, mTOR inhibitor, c-Met inhibitors, Src inhibitors, PARP inhibitors, angiopoietins, ALK inhibitors, ROS-1 inhibitors, anti-(IGF) antibodies, taxane antineoplastic agents, topoisomerase II inhibitors, antitumor antibiotics, HSP90 one or more immunotherapeutic agents selected from the group consisting of inhibitors, Aurora kinase inhibitors, PSA directed vaccines, GR antagonists, 11-beta HSD inhibitors, anti-CTLA4 antibodies, anti-PD1 antibodies and anti-PDL1 antibodies. The combination product according to [18] above.
[20] The combination product of [19] above, wherein the immunotherapeutic agent is selected from the group consisting of ipilimumab, tremelimumab, nivolumab, pembrolizumab, CT-011, AMP-224, MPDL3280A, MEDI4736 and MDX-1105.
[21] The compound of any one of [1] to [13] above for the manufacture of a medicament for the treatment of diseases or conditions susceptible to amelioration by antagonism of androgen receptors and/or glucocorticoid receptors. Use of.
[22] Diseases or conditions susceptible to amelioration by androgen receptor and/or glucocorticoid receptor antagonism include prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, stomach cancer, lung cancer, breast cancer, Colon cancer, colorectal cancer, ovarian cancer, and other solid tumors, melanoma, metastatic cancer, benign prostatic hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting The use according to [21] above, selected from disease and cachexia, and Cushing's syndrome, antipsychotic-induced weight gain, obesity, post-traumatic stress disorder, and alcoholism.
[23] A disease susceptible to amelioration by androgen receptor and/or glucocorticoid receptor antagonism, comprising administering the compound of any one of [1] to [13] above to a subject in need thereof or how to treat a medical condition.
[24] Diseases or conditions susceptible to amelioration by androgen receptor and/or glucocorticoid receptor antagonism include prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, stomach cancer, lung cancer, breast cancer, Colon cancer, colorectal cancer, ovarian cancer, and other solid tumors, melanoma, metastatic cancer, benign prostatic hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting The method of [23] above, wherein the disease and cachexia are selected from Cushing's syndrome, antipsychotic-induced weight gain, obesity, post-traumatic stress disorder, and alcoholism.
The invention is further described in the following examples. The following is given as an illustration and in no way limits the scope of this invention. The synthesis of the compounds of this invention, including the preparation of intermediates, is illustrated by the following examples, which in no way limit the scope of the invention.

Example C116 : methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7- cyanobenzo [b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3- Carboxylate Following the two-step procedure described above for the synthesis of Example C114, the title compound was obtained as a yellow solid (0.035 g, 51%).
¹ H-NMR (300 MHz, CDCl ₃ ) δ (ppm): 8.41 (d, J = 8.2 Hz, 1H), 8.27 (bs, 1H), 7.66 (d, J = 7.2 Hz , 1H), 7.47 (t, J = 7.8Hz, 1H), 7.27 (s, 1H), 5.47 (s, 1H), 4.85-4.56 (m, 2H), 3.59 (s, 5H), 2.98 (s, 2H), 2.42 (s, 3H), 2.15 (s, 3H), 1.83 (s, 2H).
HRMS (IE) m/z calcd for _C22H24N3O4S [M ⁺¹ _] : _426.1482 , found: _426.1480 .
Examples C117 and C118 were prepared according to the following three-step synthesis:

Embodiment 13:
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 1),
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 2),
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-5-benzoyl-2,6-dimethyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-phenyl-1,4-dihydropyridine-3-carboxylate,
3-acetyl-4-(benzo[b]thiophen-3-yl)-2,7,7-trimethyl-4,6,7,8-tetrahydro-quinolin-5(1H)-one,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-nicotinoyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydro-[2,3′-bipyridine]-3-carboxylate,
2,2,2-trifluoroethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(4-methylpiperazine-1-carbonyl)-1,4-dihydropyridin-3-yl)ethane-1- on,
5-acetyl-4-(benzo[b]thiophen-3-yl)-N,N-diethyl-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(morpholine-4-carbonyl)-1,4-dihydropyridin-3-yl)ethan-1-one,
2-methoxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-acetamidopropyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
2-morpholinoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-(dimethylamino)ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-acetamidoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(methoxymethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((dimethylamino)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-methoxybenzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
5-(benzo[b]thiophen-3-yl)-5,10-dihydro-1H,3H-dipyrano[3,4-b:4′,3′-e]pyridine-4,6(7H,9H) - dione,
pyridin-2-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(morpholino-methyl)-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(benzo[b]thiophen-3-yl)-2,6-bis(morpholinomethyl)-1,4-dihydropyridine-3,5-dicarboxylate,
2-hydroxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethan-1-one,
Methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(1-(tert-butoxycarbonyl)azetidin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxy rate,
3-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-1,4,7,8-tetrahydro-5H-6,8-methano-1,6-naphthyridin-5-one,
(1-(tert-butoxycarbonyl)piperidin-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate ,
cyclohexylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-N-phenyl-1,4-dihydropyridine-3-carboxamide,
tetrahydro-2H-pyran-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxy-2-oxoethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(2-methylbenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxyethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((benzyloxy)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(phenoxymethyl)-1,4-dihydropyridine-3-carboxylate,
phenethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
3-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-4,8-dihydro-1H-pyrano[3,4-b]pyridin-5(6H)-one,
methyl 4-(benzo[b]thiophen-3-yl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-benzyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(2-phenylacetyl)-1,4-dihydropyridine-3-carboxylate,
3-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-4,8-dihydro-1H-thiopyrano[3,4-b]pyridin-5(6H)-one,
methyl 4-(benzo[b]thiophen-3-yl)-5-(2-methoxyacetyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-(methoxymethyl)-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(fluoromethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(tert-butoxycarbonyl)piperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-methylpiperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclobutyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[3,2-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-6-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(Tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
benzyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
6-acetyl-5-(benzo[b]thiophen-3-yl)-1,3,7-trimethyl-5,8-dihydro-pyrido[2,3-d]pyrimidine-2,4(1H,3H) - dione,
3-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-4,7-dihydrofuro[3,4-b]pyridin-5(1H)-one,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-benzyl-6-methyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1-(5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3-yl)-2-phenylethan-1-one,
methyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
1-(2-methyl-5-(piperidine-1-carbonyl)-4-(thieno[2,3-b]pyridin-3-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3 -yl) ethane-1-one,
4-(((5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carbonyl)oxy)methyl)benzoic acid,
benzyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-(cyclopropylcarbamoyl)benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4 dihydropyridine-3-carboxylate,
4-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(3-fluoropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyrimidin-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(5-bromopyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(6-chloropyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-morpholinobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(2-chloropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
tetrahydro-2H-pyran-4-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
5-acetyl-N-benzyl-N,2,6-trimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxamide,
oxetane-3-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
isopropyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
Methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(2,2,2-trifluoroacetyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopentyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-diamino-4-(benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-acetamido-5-acetyl-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2,6-diamino-4-(7-cyanobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
5-(cyclopropylmethyl)3-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(4-fluorobenzyl) 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(4-fluorobenzyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-methyl-6-phenyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarbonitrile,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carbonitrile,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-methyl-6-phenyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-diyl)diethanone,
9-(benzo[b]thiophen-3-yl)-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione,
1,1′-(4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-morpholinobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazin-1-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(4-(5-(benzylamino)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)bis(ethane-1- on),
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carbonitrile,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
N-cyclopropyl-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
N-(cyclopropylmethyl)-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethane -1-on),
1,1′-(2,6-dimethyl-4-(thieno[3,2-c]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
1,1′-(2,6-dimethyl-4-(thieno[2,3-c]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
1,1′-(2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one,
methyl 4-(benzo[b]thiophen-3-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydro-pyridine-3,5-diyl)diethanone,
3-acetyl-4-(benzo[b]thiophen-3-yl)-1,4,6,7-tetrahydro-2-methylcyclopenta[b]pyridin-5-one,
3-acetyl-4-(benzo[b]thiophen-3-yl)-1,4,6,7,8-pentahydro-2-methyl-7-phenylcyclohexa[b]pyridin-5-one,
3-acetyl-4-(benzo[b]thiophen-3-yl)-7-(4-fluorophenyl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(methylsulfonyl)-1,4-dihydro-pyridin-3-yl)ethanone,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-(3-acetyl-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
methyl 5-acetyl-4-(5-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-((cyclopropylmethyl)carbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[3,2-c]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-c]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(5-fluorobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2,6-dicyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
3-(3-acetyl-6-cyclopropyl-5-(methoxycarbonyl)-2-methyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylic acid,
benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
bis(pyridin-4-ylmethyl) 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dibenzyl 2,6-dicyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
benzyl 5-acetyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylate,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carbonitrile,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
bis(4-fluorobenzyl) 2,6-dicyclopropyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
4-cyanobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(trifluoromethyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-chlorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-(4-(7-bromobenzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethane-1- on,
3-chlorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3- carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine- 3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclobutyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopentyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclohexyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3-carboxylate,
3-((4-methylpiperazin-1-yl)methyl)benzyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3- carboxylate,
3-(cyclopropylmethyl)5-methyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dicyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-cyclopropyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7- cyanobenzo [b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate hydrochloride,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate trifluoromethanesulfonate,
4-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
[3,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[3,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(pyridin-4-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-cyclopropylbenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-4-yl)benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
1,1′-(2,6-dimethyl-4-(5-(pyridin-3-yl)benzo[b]thiophen-3-yl)-1,4-dihydro-pyridine-3,5-diyl)diethanone ,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-phenylbenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate, A compound according to embodiment 1.

Claims (20)

The following general formula (I):

(In the formula,
- R ¹ is
a) ^-COR5 ,
b) ^-COOR5 ,
c) -CN,
d) a group selected from —C(O)NH ₂ ;
- ^R5 is
a) linear or branched C ₁ -C ₆ alkyl, wherein said alkyl is one selected from —N(R ⁶ )R ⁷ and —OR ⁶ , halogen atoms, C ₃ -C ₆ cycloalkyl and alkynyl groups; , optionally substituted with 2 or 3 substituents),
b) a group selected from C ₃ -C ₆ cycloalkyl;
- ^R2 is
a) -COOR ⁸ ,
b) ^-COR8 ,
c) —C(O)N(R ⁸ )R ⁹ ,
d) -CN,
e) a group selected from —S(O) _n R ⁸ (n is an integer of 1 to 2),
- R ⁸ and R ⁹ are
a) linear or branched C ₁ -C ₆ alkyl (said alkyl optionally substituted with 1, 2 or 3 substituents selected from A ¹ or B ² ),
b) ¹ group A,
c) hydrogen atoms, or
or - R ⁸ and R ⁹ together with the nitrogen atom to which they are attached form a 5- to 6-membered heterocyclic ring optionally containing one heteroatom selected from O and N; and said heterocyclic ring is optionally substituted with 1 or 2 groups independently selected from linear or branched C ₁ -C ₄ alkyl,
- R ³ is a linear or branched C ₁ -C ₆ alkyl (wherein said alkyl is a halogen atom, 1, 2 or 3 substitutions selected from -N(R ⁶ )R ⁷ and -OR ⁶ optionally substituted with a group),
- ^R4 is
a) ¹ group A,
b) linear or branched C ₁ -C ₆ alkyl (said alkyl optionally substituted with 1, 2 or 3 substituents selected from A ¹ or B ² ),
c) —N(R ⁶ )R ⁷ ,
d) -CN,
e) -CO-H,
f) -CO-Me, and g) -CO-OMe
is a group selected from
- X ¹ and X ⁴ are independently selected from C-B ¹ , N and C-H;
- X ² , X ³ and X ⁵ are independently selected from C—B ¹ and C—H;
- A ¹ is
a) C ₃ -C ₆ cycloalkyl (wherein said cycloalkyl ring is optionally substituted with 1, 2, 3 or 4 substituents selected from ═O and B ³ ),
b) a 3- to 6-membered saturated heterocyclyl ring containing 1, 2 or 3 heteroatoms selected from O, S and N, wherein said ring has 1 selected from =O and B ³ , optionally substituted with 2 or 3 substituents),
c) a phenyl group or a 5- to 6-membered heteroaryl group (either the phenyl group or the heteroaryl group may be substituted with 1, 2 or 3 substituents selected from B ¹ good), selected from
- each B ¹ is a halogen atom, -CF ₃ group, 5- to 6-membered heteroaryl, linear or branched C ₁ -C ₆ alkyl, -CN, -N(R ⁶ )R ⁷ , -OR ⁶ , -C(=O)R ⁶ , -C(=O)OR ⁶ , -C(=O)N(R ⁶ )R ⁷ , -OC(=O)-R ⁶ , -N(R ⁶ )C independently selected from (=O)R ⁷ , —NR ⁷ SO ₂ R ⁶ , —SO ₂ N(R ⁶ )R ⁷ , —SR ⁶ , —S(O)R ⁶ and —S(O) ₂ R ⁶ is,
- each B ² is a halogen atom, -CN, -N(R ⁶ )R , -OR ⁶ , -C(=O)R ⁶ , -C(=O) ^{OR 6 ,} -C(=O)N (R ⁶ )R ⁷ , —OC(=O)—R ⁶ , —N(R ⁶ )C(=O)R ⁷ , —NR ⁷ SO ₂ R ⁶ , —SO ₂ N(R ⁶ )R ⁷ , independently selected from —SR ⁶ , —S(O)R ⁶ , —S(O) ₂ R ⁶ , and an alkynyl group;
- each B ³ is a halogen atom, linear or branched C ₁ -C ₆ alkyl, -CN, -N(R ⁶ )R ⁷ , -OR ⁶ , -C(=O)R ⁶ , -C( =O)OR ⁶ , -C(=O)N(R ⁶ )R ⁷ , -OC(=O)-R ⁶ , -N(R ⁶ )C(=O)R ⁷ , -NR ⁷ SO ₂ R ⁶ , —SO ₂ N(R ⁶ )R ⁷ , —SR ⁶ , —S(O)R ⁶ , —S(O) ₂ R ⁶ ,
Each ^R6 and ^R7 is
- hydrogen atoms,
- linear or branched C ₁ -C ₁₂ alkyl, C ₃ -C ₆ cycloalkyl and C ₄ -C ₆ heterocycloalkyl (said alkyl, said cycloalkyl, said heterocycloalkyl are ═O(oxo) , halogen atom, hydroxy, phenyl, C ₃ -C ₆ cycloalkyl, linear or branched C ₁ -C ₆ alkoxy, amino, alkylamino, dialkylamino, linear or branched C ₁ -C ₆ alkylcarbonyl optionally substituted with 1, 2 or 3 substituents selected from
- a phenyl group or a 5- to 6-membered heteroaryl group (said phenyl group, said heteroaryl group is a halogen atom, a cyano group, a linear or branched C ₁ -C ₆ alkyl, a linear or branched C ₁ - optionally substituted with 1, 2 or 3 substituents selected from C ₆ haloalkyl, hydroxy, linear or branched C ₁ -C ₆ alkoxy, amino, alkylamino, dialkylamino) ;
- R ⁶ and R ⁷ , together with the nitrogen atom to which they are attached, form a 3- to 8-membered ring, optionally containing a further heteroatom selected from O, N and S ( Said ring is from =O (oxo), linear or branched C ₁ -C ₆ alkyl, linear or branched C ₁ -C ₆ haloalkyl, linear or branched C ₁ -C ₆ alkylcarbonyl independently substituted with 1, 2 or 3 selected substituents;
- provided that when R ¹ is -COOR ⁵ and R ² is -COOR ⁸ , R ⁴ is not a methyl group)
or a pharmaceutically acceptable salt thereof. X ¹ , X ² , X ³ and X ⁵ represent C—H or C—B ^{1 (wherein B 1 represents} a halogen atom), a compound according to claim 1 or a pharmaceutically acceptable Salt to be served. 3. The compound of claim 2, or a pharmaceutically acceptable salt thereof, wherein X ⁴ is a group selected from CB ¹ and N. 4. The compound of Claim 3, or a pharmaceutically acceptable salt thereof, wherein B ¹ is selected from -CN groups and halogen atoms. The compound according to any one of claims 2 to 4, or a pharmaceutically acceptable salt thereof, wherein R ¹ is a group selected from -COR ⁵ , -COOR ⁵ and -CN groups. ^R5 is
- C ₁ -C ₄ alkyl, wherein the terminal methyl of said alkyl is unsubstituted or substituted with 3 fluorine atoms (-CF ₃ ),
- C ₁ -C ₃ alkyl (wherein said alkyl may be substituted at any position with an alkynyl group), and - C ₃ -C ₅ cycloalkyl, or a compound thereof according to claim 5. pharmaceutically acceptable salts. A compound according to any one of claims 2 to 6, wherein R ² represents -COOR ⁸ , or a pharmaceutically acceptable salt thereof. ^R8 is
- linear or branched C ₁ -C ₆ alkyl, said alkyl being selected from fluorine atoms and C ₃ -C ₅ cycloalkyl optionally substituted by 1, 2 or 3 fluorine atoms, optionally substituted with 1, 2, or 3 substituents), or - A ¹ group, wherein said A ¹ group is 1 selected from the group consisting of a fluorine atom and a C ₁ -C ₃ alkyl group or a pharmaceutically acceptable salt thereof according to claim 7, which independently represents C ₃ -C ₆ cycloalkyl optionally substituted with 1, 2 or 3 substituents. R ³ is linear or branched C ₁ -C ₄ alkyl (said group may be substituted with 1, 2 or 3 fluorine atoms), the A compound according to any one of claims or a pharmaceutically acceptable salt thereof. ^R4 is
— —N(R ⁶ )R ⁷ (wherein R ⁶ and R ⁷ are independently selected from a hydrogen atom and linear or branched C ₁ -C ₃ alkyl),
- A ¹ group, said A ¹ group representing C ₃ -C ₆ cycloalkyl,
- linear or branched C ₁ -C ₃ alkyl, wherein said alkyl is substituted with 1, 2 or 3 substituents selected from 1, 2 or 3 fluorine atoms or 1 hydroxyl group or a pharmaceutically acceptable salt thereof according to any one of claims 2 to 9, which is a group selected from X ¹ , X ² , X ³ and X ⁵ represent —CH, X ⁴ represents C—B ¹ (wherein B ¹ represents a —CN group or a bromine atom), R ¹ represents —C (O)CH ₃ , —C(O)OCH ₃ , —C(O)OCH ₂ -alkynyl, and CN, wherein R ² is —C(O)O—linear or branched and C ₍ O)OCH ₂ -cyclopropyl (wherein said cyclopropyl is _one , optionally substituted with 2 or 3 fluorine atoms, R ³ is linear or branched C ₁ -C ₃ alkyl, and R ⁴ is 2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, which is a group selected from linear or branched C ₁ -C ₃ alkyl, C ₃ -C ₄ cycloalkyl and —NH ₂ . X ¹ , X ² , X ³ and X ⁵ represent —CH, X ⁴ represents C—B ¹ (wherein B ¹ represents a —CN group), R ¹ represents —C(O)CH ₃ , a group selected from —C(O)OCH ₃ , and R ² is —C(O)OCH ₂ -cyclopropyl, wherein said cyclopropyl is substituted with 1, 2 or 3 fluorine atoms; and —C(O)OCH ₂ —CF ₃ , R ³ is methyl and R ⁴ is a group selected from cyclopropyl and —NH ₂ The compound according to claim 1, or a pharmaceutically acceptable salt thereof, which is methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 1),
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate (enantiomer 2),
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-5-benzoyl-2,6-dimethyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-phenyl-1,4-dihydropyridine-3-carboxylate,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-nicotinoyl-1,4-dihydropyridin-3-yl)ethan-1-one,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydro-[2,3′-bipyridine]-3-carboxylate,
2,2,2-trifluoroethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(4-methylpiperazine-1-carbonyl)-1,4-dihydropyridin-3-yl)ethane-1- on,
5-acetyl-4-(benzo[b]thiophen-3-yl)-N,N-diethyl-2,6-dimethyl-1,4-dihydropyridine-3-carboxamide,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(morpholine-4-carbonyl)-1,4-dihydropyridin-3-yl)ethan-1-one,
2-methoxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-acetamidopropyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylate,
2-morpholinoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-(dimethylamino)ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
2-acetamidoethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(methoxymethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((dimethylamino)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-methoxybenzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-2-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(morpholino-methyl)-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(benzo[b]thiophen-3-yl)-2,6-bis(morpholinomethyl)-1,4-dihydropyridine-3,5-dicarboxylate,
2-hydroxyethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethan-1-one,
Methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(1-(tert-butoxycarbonyl)azetidin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxy rate,
(1-(tert-butoxycarbonyl)piperidin-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate ,
cyclohexylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-N-phenyl-1,4-dihydropyridine-3-carboxamide,
tetrahydro-2H-pyran-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxy-2-oxoethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(2-methylbenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(2-methoxyethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-((benzyloxy)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(phenoxymethyl)-1,4-dihydropyridine-3-carboxylate,
phenethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-benzyl-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(2-phenylacetyl)-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-(2-methoxyacetyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-(methoxymethyl)-2-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-(fluoromethyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1-(tert-butoxycarbonyl)piperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-methylpiperidin-4-yl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclobutyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[3,2-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-methyl-6-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(Tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
benzyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
(tetrahydro-2H-pyran-4-yl)methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-benzyl-6-methyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1-(5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3-yl)-2-phenylethan-1-one,
methyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
1-(2-methyl-5-(piperidine-1-carbonyl)-4-(thieno[2,3-b]pyridin-3-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3 -yl) ethane-1-one,
4-(((5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carbonyl)oxy)methyl)benzoic acid,
benzyl 5-acetyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-3-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
4-(cyclopropylcarbamoyl)benzyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4 dihydropyridine-3-carboxylate,
4-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-bromobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(3-fluoropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyrimidin-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(5-bromopyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-cyanobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(6-chloropyridin-3-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-morpholinobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-dimethylcyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
(2-chloropyridin-4-yl)methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
tetrahydro-2H-pyran-4-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
5-acetyl-N-benzyl-N,2,6-trimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxamide,
oxetane-3-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
isopropyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
Methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(2,2,2-trifluoroacetyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-4-(benzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-amino-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
Dimethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Cyclopentyl 5-acetyl-2-amino-4-( 7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4,4-difluorocyclohexyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 2-acetamido-5-acetyl-4-(5-fluorothieno[2,3-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopentylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(4-fluorobenzyl) 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 2-amino-5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-cyclopentyl 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-2-amino-4-(6-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexylmethyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-fluorobenzyl 5-acetyl-2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(cyclobutylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((3,3-difluorocyclobutyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5 - a dicarboxylate,
cyclopropylmethyl 2-amino-5-carbamoyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-((2,2-difluorocyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5 - a dicarboxylate,
5-cyclopropyl 3-(cyclopropylmethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-4-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-isopropyl 5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-((2,2-difluoro-3,3-dimethylcyclopropyl)methyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4 - dihydropyridine-3,5-dicarboxylate,
5-methyl 3-neopentyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanothieno[3,2-b]pyridin-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
bis(cyclopropylmethyl) 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-(prop-2-yn-1-yl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(5,7-dicyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate ,
5-(but-2-yn-1-yl)3-(cyclopropylmethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
5-methyl 3-(2,2,2-trifluoroethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5- dicarboxylate,
3-(Cyclopropylmethyl)5-(2,2,2-trifluoroethyl)2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine- 3,5-dicarboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(6-chloro-7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
3-(2-fluoro-2-methylpropyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-di carboxylate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyano-6-(trifluoromethyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3 , 5-dicarboxylate,
5-methyl 3-prop-2-yn-1-yl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxy rate,
3-(Cyclopropylmethyl)5-methyl 2-amino-4-(7-cyanobenzo[b]thiophen-3-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarboxy rate,
4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile,
2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-methyl-6-phenyl-1,4-dihydropyridine-3,5-dicarbonitrile,
4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarbonitrile,
5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carbonitrile,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-methyl-6-phenyl-1,4-dihydropyridine-3-carboxylate,
ethyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 4-(benzo[b]thiophen-3-yl)-5-cyano-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(6-hydroxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(4-(6-methoxybenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone,
1,1′-(4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-morpholinobenzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethan-1-one),
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazin-1-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(4-(5-(benzylamino)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)bis(ethane-1- on),
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carbonitrile,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
N-cyclopropyl-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
N-(cyclopropylmethyl)-3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxamide,
1,1′-(2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl) bis(ethane-1-one),
1,1′-(2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3,5-diyl)bis(ethane -1-on),
1,1′-(2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridin-3,5-diyl)bis(ethan-1-one) ,
dimethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-2,3-dicarboxylate,
dimethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-2,3-dicarboxylate,
methyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
ethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
1,1′-(4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydro-pyridine-3,5-diyl)diethanone,
1-(4-(benzo[b]thiophen-3-yl)-2,6-dimethyl-5-(methylsulfonyl)-1,4-dihydro-pyridin-3-yl)ethanone,
methyl 5-acetyl-4-(5-fluorobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-cyanobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
3-(3-acetyl-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-5-carboxylic acid,
methyl 5-acetyl-4-(5-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-((cyclopropylmethyl)carbamoyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(4-methylpiperazine-1-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(5-(morpholine-4-carbonyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(5-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(cyclopropylcarbamoyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-(3-acetyl-6-cyclopropyl-5-(methoxycarbonyl)-2-methyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylic acid,
benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(benzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(5-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
pyridin-4-ylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-2-cyclopropyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
benzyl 5-acetyl-4-(7-(methoxycarbonyl)benzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate,
methyl 3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carboxylate,
3-(3,5-diacetyl-2,6-dimethyl-1,4-dihydropyridin-4-yl)benzo[b]thiophene-7-carbonitrile,
pyridin-4-ylmethyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
4-fluorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-cyanobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-chlorobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(trifluoromethyl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-chlorobenzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclohexyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-phenylpropan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
1-(4-(7-bromobenzo[b]thiophen-3-yl)-5-(cyclopropanecarbonyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridin-3-yl)ethane-1- on,
3-chlorobenzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3- carboxylate,
2-(4-fluorophenyl)propan-2-yl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine- 3-carboxylate,
methyl 5-acetyl-2-cyclopropyl-4-(7-fluorobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopentyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 5-acetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclobutyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclopentyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2-cyclohexyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
3-((4-methylpiperazin-1-yl)methyl)benzyl 5-acetyl-4-(7-bromobenzo[b]thiophen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3- carboxylate,
3-(cyclopropylmethyl)5-methyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 2-cyano-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7-bromobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-((2-aminoethoxy)methyl)-4-(7- cyanobenzo [b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-(hydroxymethyl)-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 4-(7-cyanobenzo[b]thiophen-3-yl)-2-formyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,
dimethyl 2-cyano-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate,
cyclopropylmethyl 5-acetyl-4-(6-cyanobenzo[b]thiophen-3-yl)-2-cyclopropyl-6-methyl-1,4-dihydropyridine-3-carboxylate,
cyclopropylmethyl 2,5-diacetyl-4-(7-cyanobenzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate hydrochloride,
methyl 5-acetyl-2-amino-4-(benzo[b]thiophen-3-yl)-6-methyl-1,4-dihydropyridine-3-carboxylate trifluoromethanesulfonate,
4-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
4-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
3-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-4-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
2-(pyridin-3-yl)benzyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate,
[3,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[3,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-5-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,3′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
[2,4′-bipyridin]-4-ylmethyl 5-acetyl-2,6-dimethyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxylate ,
methyl 5-acetyl-2-cyclopropyl-6-methyl-4-(7-(pyridin-4-yl)benzo[b]thiophen-3-yl)-1,4-dihydropyridine-3-carboxylate ,
3- (pyridin-4-yl)benzyl 5-acetyl-2-cyclopropyl-6-methyl-4-(thieno[2,3-b]pyridin-3-yl)-1,4-dihydropyridine-3-carboxy rate,
1,1′-(2,6-dimethyl-4-(5-(pyridin-3-yl)benzo[b]thiophen-3-yl)-1,4-dihydro-pyridine-3,5-diyl)diethanone The compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from the group consisting of A pharmaceutical composition comprising a compound according to any one of claims 1 to 13 or a pharmaceutically acceptable salt thereof. 15. The pharmaceutical composition of Claim 14, further comprising a pharmaceutically acceptable diluent or carrier. Prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, gastric cancer, lung cancer, breast cancer, colon cancer, colorectal cancer, ovarian cancer, and other solid tumors, melanoma, metastatic cancer, benign prostatic hyperplasia, multiple Cystic ovarian syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting disorders and cachexia, and Cushing's syndrome, antipsychotic-induced weight gain, obesity, post-traumatic stress disorder, and alcohol 16. A pharmaceutical composition according to claim 14 or 15 for use in the treatment of diseases or conditions susceptible to amelioration by antagonism of the androgen receptor and/or the glucocorticoid receptor selected from addictions. Prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, gastric cancer, lung cancer, breast cancer, colon cancer, colorectal cancer, ovarian cancer, and other solid tumors, melanoma, metastatic cancer, benign prostatic hyperplasia, multiple Cystic ovarian syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting disorders and cachexia, and Cushing's syndrome, psychotropic drug-induced weight gain, obesity, post-traumatic stress disorder, and alcohol 17. The pharmaceutical composition according to any one of claims 14-16, further comprising a therapeutically effective amount of a therapeutic agent selected from agents for treating addiction. A compound according to any one of claims 1 to 13 or a pharmaceutically acceptable salt thereof, and prostate cancer, castration-resistant prostate cancer, pancreatic cancer, bladder cancer, renal cancer, gastric cancer, lung cancer, breast cancer, colon cancer , colorectal cancer, ovarian cancer, and other solid tumors, melanoma, metastatic cancer, benign prostatic hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting disease and A combination product comprising cachexia and therapeutic agents used to treat Cushing's syndrome, antipsychotic-induced weight gain, obesity, post-traumatic stress disorder, and alcoholism. Said therapeutic agents are agonists or antagonists of gonadotropin releasing hormone (GnRH) receptors, androgen receptor antagonists, CYP17 inhibitors, VEGF inhibitors, EGFR inhibitors, PI3K inhibitors, AKT inhibitors, mTOR inhibitors, c-Met inhibitors, Src inhibitors, PARP inhibitors, angiopoietins, ALK inhibitors, ROS-1 inhibitors, anti-(IGF) antibodies, taxane antineoplastic agents, topoisomerase II inhibitors, antitumor antibiotics, HSP90 inhibitors, one or more immunotherapeutic agents selected from the group consisting of Aurora kinase inhibitors, PSA-directed vaccines, GR antagonists, 11-beta HSD inhibitors, anti-CTLA4 antibodies, anti-PD1 antibodies and anti-PDL1 antibodies; 19. Combination product according to claim 18. 20. The combination product of claim 19, wherein the immunotherapeutic agent is selected from the group consisting of ipilimumab, tremelimumab, nivolumab, pembrolizumab, CT-011, AMP-224, MPDL3280A, MEDI4736 and MDX-1105.