JPWO2018061771A1 - Component measuring device set and component measuring chip - Google Patents

Abstract

The component measuring device set according to the present disclosure is mounted with a component measuring chip having a reagent that causes a color reaction with a component to be measured in body fluid, and the component measuring chip, and the color reaction between the component to be measured and the reagent And a component measuring device for measuring the component to be measured based on the optical characteristics of the obtained reactant, wherein the component measuring chip and the component measuring device indicate relative positions of the component measuring chip to the component measuring device. A plurality of concavo-convex parts which are constituted by a convex part and a concave part which engage so as to maintain a predetermined mounting position are provided.

Description

  The present disclosure relates to a component measurement device set and a component measurement chip.

  BACKGROUND Conventionally, a component measuring device for measuring a component to be measured which is a predetermined component in body fluid such as blood and urine has been widely spread. As a measurement principle, for example, a component to be measured in body fluid is reacted with an enzyme or the like, a voltage is applied to the reaction product, a current flowing is measured, and a so-called "electrode method" The component measuring apparatus to utilize is known. In addition, as another measurement principle, component measurement using so-called "colorimetry" in which the component to be measured in the body fluid is subjected to color reaction with the reagent and the optical characteristic of the reaction product is measured to measure the component to be measured. Devices are also known.

  Patent Document 1 describes a system including a meter using a so-called "colorimetric method" and a test strip attached to the meter.

Japanese Patent Application Publication No. 2008-513788

  By the way, in the case of the component measuring apparatus using the above-mentioned "electrode method", if the body fluid and the electrode can be brought into contact with each other, the component to be measured in the body fluid can be measured relatively stably. Therefore, with regard to the mounting position of the component measuring chip with respect to the component measuring device using the "electrode method", particularly high positional accuracy is not required as long as the two electrical contacts can be reliably brought into contact with each other. On the other hand, in the above-mentioned "colorimetry" which measures an optical characteristic, the measurement error of a to-be-measured component tends to become large by the position accuracy of the reactant with respect to the measuring system of a component measuring device. Therefore, the arrangement position of the reactant with respect to the measurement system of the component measurement device is required to have high positional accuracy as compared with the “electrode method”.

  Patent Document 1 describes a system as a component measuring device set including a test strip as a component measuring chip and a meter as a component measuring device, but the position of the test strip relative to the meter at the test position There is room for further improvement in maintaining high accuracy.

  An object of the present disclosure is to provide a component measuring device set and a component measuring chip capable of improving the positional accuracy of the mounting position of the component measuring chip with respect to a component measuring device using a so-called “colorimetric method”.

  According to a first aspect of the present invention, a component measuring apparatus set includes: a component measuring chip having a reagent that causes a color reaction with a component to be measured in body fluid; and the component measuring chip mounted thereon; And a component measuring device that measures the component to be measured based on optical characteristics of a reactant obtained by a color reaction, wherein the component measuring chip and the component measuring device measure the component of the component measuring chip A plurality of concavo-convex parts constituted by a convex part and a concave part engaged so as to maintain a relative position to the device at a predetermined mounting position are provided.

  As one embodiment of the present invention, the component measurement chip defines a flow path in which the reagent is stored, and the thickness of the component measurement chip is in a state where the component measurement chip is at the predetermined mounting position. When viewed from the direction, the plurality of uneven portions are located on both sides of the flow path.

  As one embodiment of the present invention, when viewed from the thickness direction of the component measurement chip in a state where the component measurement chip is at the predetermined mounting position, the component measurement chip has the plurality of irregularities rather than the plurality of uneven portions. A grip is provided at a position away from the reagent.

  As one embodiment of the present invention, at least one uneven portion of the plurality of uneven portions has the component such that another uneven portion is engaged when the component measuring chip is attached to the component measuring device. A guide unit is provided to guide the movement of the measuring chip relative to the component measuring device.

  As one embodiment of the present invention, the at least one uneven portion is formed on the outer edge of the component measurement chip, and an outer edge convex portion having a shape whose width gradually decreases toward the tip, and the component measuring device And an inner wall recess formed on the inner wall of the chip mounting space capable of receiving the component measurement chip and having a shape whose width gradually decreases toward the concave bottom.

  As one embodiment of the present invention, at least one uneven portion of the plurality of uneven portions is provided in one of the component measuring chip and the component measuring device in a state where the component measuring chip is in the predetermined mounting position. And a convex portion projecting in the thickness direction of the component measurement chip, and a concave portion provided on the other side and in which the convex portion is fitted.

  As one embodiment of the present invention, the convex portion of the at least one uneven portion is a protrusion formed in the component measuring device, and the concave portion of the at least one uneven portion is the component measurement chip A recess or a hole formed in the

  As one embodiment of the present invention, the component measuring device is configured such that the position, size or number of projections or recesses formed on the component measuring chip is in a state where the component measuring chip is in the predetermined mounting position. A detection unit is provided for detecting, and measurement conditions for measuring the component to be measured are set according to the detection value of the detection unit.

  The component measurement chip according to the second aspect of the present invention has a reagent that causes a color reaction with the component to be measured in the body fluid, and the optical of the reactant obtained by the color reaction of the component to be measured and the reagent A component measuring chip mounted on a component measuring device for measuring the component to be measured based on a characteristic, wherein the component measuring device is formed to maintain the relative position to the component measuring device at a predetermined mounting position. A concave portion engaged with the convex portion and a convex portion engaged with the concave portion formed in the component measuring device, or to maintain the relative position to the component measuring device at a predetermined mounting position, A plurality of concave portions that engage with the convex portions formed in the component measuring device or convex portions that engage with the concave portions formed in the component measuring device are provided.

  According to the present disclosure, it is possible to provide a component measurement device set and a component measurement chip capable of improving the positional accuracy of the mounting position of the component measurement chip with respect to a component measurement device using a so-called “colorimetric method”.

It is a top view of a component measuring device set as one embodiment. FIG. 5 is an enlarged cross-sectional view in the vicinity of a portion where the component measurement chip is mounted in the cross section along the line II of FIG. 1; FIG. 2 is a cross-sectional view taken along the line II-II in FIG. It is a top view of the component measurement chip single-piece | unit shown in FIG. It is an electric block diagram of the component measuring device shown in FIG. It is a figure which shows the outline | summary of one mounting method at the time of mounting | wearing the component measuring chip shown in FIG. 1 with respect to a component measuring apparatus. It is a figure which shows the outline | summary of one mounting method at the time of mounting | wearing the component measuring chip shown in FIG. 1 with respect to a component measuring apparatus. It is a figure which shows the modification of the 2nd uneven part shown in FIG. It is a figure which shows the modification of the 2nd uneven part shown in FIG. It is a figure which shows separately the component measurement apparatus and component measurement chip | tip of a component measurement apparatus set as one Embodiment.

  Hereinafter, embodiments of the component measuring device set and the component measuring chip will be described with reference to FIGS. 1 to 10. The same code | symbol is attached | subjected to the member and site | part which are common in each figure.

  FIG. 1 is a top view showing a component measuring device set 100 as one embodiment of a component measuring device set according to the present invention. As shown in FIG. 1, the component measuring device set 100 is a component measuring device 1 using the “colorimetric method”, and the component measuring as one embodiment of the present invention mounted on this component measuring device 1 And a chip 2. In FIG. 1, for convenience of explanation, a part of the component measuring device 1 and the component measuring chip 2, which is located in the component measuring device 1 and is not visible in top view, is indicated by a broken line.

  FIG. 2 is an enlarged cross-sectional view of the vicinity of the portion where the component measurement chip 2 is mounted in the cross section along the line II of FIG. FIG. 3 is a cross-sectional view taken along the line II-II in FIG. Furthermore, FIG. 4 is a top view of a single component measuring chip 2. In FIG. 3, for convenience of explanation, a part of the component measuring device 1 and the component measuring chip 2 which is located in the component measuring device 1 and is not visible in a cross sectional view is indicated by a broken line.

  As shown in FIGS. 2 to 4, the component measurement chip 2 divides the flow path 23 inside. The flow path 23 accommodates a color developing reagent 22 as a reagent that causes a color reaction with the component to be measured in the body fluid. Further, as shown in FIGS. 1 to 3, the component measuring chip 2 can be attached to the component measuring device 1. Then, the component measuring apparatus 1 has the optical characteristics of the reaction product obtained by the color reaction of the component to be measured in the body fluid and the coloring reagent 22 in a state where the component measuring chip 2 is attached to the component measuring apparatus 1 The component to be measured can be measured based on that.

  Hereinafter, the detail of the component measuring device set 100 of this embodiment is demonstrated. The component measuring device 1 of the present embodiment is a blood glucose level measuring device capable of measuring the glucose concentration (mg / dL) in plasma as a component to be measured in blood. Moreover, the component measurement chip 2 of the present embodiment is a blood glucose level measurement chip that can be attached to the blood glucose level measurement device as the component measurement device 1. As described above, in the present embodiment, measurement of glucose concentration in blood is described as measurement of a component to be measured in body fluid. However, a blood glucose level measuring device and a blood glucose level measurement chip for measuring glucose concentration in blood For example, the component measuring device and component measuring chip can measure various measurement components such as measurement of lactic acid concentration, uric acid concentration or cholesterol concentration in blood, urine protein concentration, and the like.

<Component measurement chip 2>
First, the component measurement chip 2 will be described. As shown in FIGS. 1 to 4, the component measurement chip 2 of the present embodiment is formed in a plate shape, and has a substantially rectangular outer shape in top view (see FIG. 4). More specifically, the component measurement chip 2 of the present embodiment includes a base member 21 having a substantially rectangular plate-like outer shape, a cover member 25 disposed to face the base member 21 so as to cover the base member 21, and the base member 21. And two spacer members 27 for maintaining the distance between them and the cover member 25 at a predetermined distance. The cover member 25 has an outer shape substantially the same as that of the base member 21 in the top view (see FIG. 4) of the component measurement chip 2 and substantially the entire area of the base member 21 and the cover member 25 overlap in the top view. There is. The flow path 23 of the component measurement chip 2 of the present embodiment is formed by being surrounded by the base member 21, the cover member 25 and the two spacer members 27. Further, the coloring reagent 22 as the reagent of the present embodiment is applied to the upper surface of the base member 21 as an inner wall partitioning the flow passage 23 so as not to block the flow passage 23. Is located in In other words, a gap 28 is formed between the coloring reagent 22 on the upper surface of the base member 21 and the lower surface of the cover member 25 facing the coloring reagent 22.

  The flow path 23 extends in a direction orthogonal to the thickness direction A of the component measurement chip 2 and penetrates from one side end surface of the component measurement chip 2 to another side end surface. More specifically, the flow path 23 of the present embodiment is orthogonal to the longitudinal direction (vertical direction in FIG. 4) of the substantially rectangular component measurement chip 2 in top view (see FIG. 4) of the component measurement chip 2 It extends in the short side direction (left and right direction in FIG. 4), and penetrates from the side end face on one side of the short side direction to the side end face on the other side. On the side end face on one side of the component measurement chip 2 where one end of the flow path 23 is formed, a cylindrical supply portion 24 capable of supplying blood from the outer side into the flow path 23 is formed There is. The cylindrical supply portion 24 of the present embodiment includes a protrusion formed on the outer edge of the base member 21, a protrusion formed on the outer edge of the cover member 25, and a protrusion formed on each of the two spacer members 27. The four projections of are composed by being annularly connected.

  The blood supplied from the outside of the component measurement chip 2 to the supply unit 24 moves along the flow path 23 using, for example, capillary action, reaches the holding position of the coloring reagent 22, and contacts the coloring reagent 22. . When the blood and the coloring reagent 22 come into contact with each other, the glucose as the component to be measured in the blood reacts with the coloring reagent 22, and the coloring reaction occurs at the holding position of the coloring reagent 22 and the gap 28 of the flow path 23. Reaction product is produced.

  Although the flow path 23 of this embodiment is divided by the base member 21, the cover member 25 and the two spacer members 27, the number of members for dividing the flow path is not limited to the configuration of the present embodiment. For example, the channel is formed by only two members, a base member having a groove formed on one side surface in the thickness direction A and a cover member attached to cover the one side surface on which the groove is formed. It is also possible to form. Thus, it is also possible to partition the flow path of the component measurement chip by three or less members. Moreover, it is also possible to form the flow path divided by five or more members.

  Moreover, the component measurement chip 2 of the present embodiment is provided with the grip portion 29 which is easy to grip when the user operates. The grip portion 29 of the present embodiment is formed at one end in the longitudinal direction in a top view of the component measurement chip 2 (see FIG. 4).

  As a material of the base member 21 and the cover member 25, it is preferable to use a transparent material for transmitting light. For example, transparent organic resin materials such as polyethylene terephthalate (PET), polymethyl methacrylate (PMMA), polystyrene (PS), cyclic polyolefin (COP), cyclic olefin copolymer (COC), and polycarbonate (PC); glass, quartz, etc. Transparent inorganic materials;

  Further, the spacer member 27 can be formed of the same material as the base member 21 and the cover member 25 regardless of whether it is transparent or opaque. For example, organic resin materials such as polyethylene terephthalate (PET), polymethyl methacrylate (PMMA), polystyrene (PS), cyclic polyolefin (COP), cyclic olefin copolymer (COC), polycarbonate (PC) and the like; inorganic materials such as glass and quartz ; The spacer member 27 formed of these materials is adhered to the base member 21 and the cover member 25 using an adhesive, but instead of such a configuration, it has a substrate formed of the above-described material. A double-sided tape may be used.

  The coloring reagent 22 as a reagent reacts with the component to be measured in blood to cause a color reaction which causes a color to be colored in accordance with the concentration of the component to be measured in blood. Is coated on the base member 21 as described above. The coloring reagent 22 of the present embodiment reacts with glucose as a component to be measured in blood. Examples of the coloring reagent 22 of the present embodiment include (i) glucose oxidase (GOD), (ii) peroxidase (POD), and (iii) 1- (4-sulfophenyl) -2,3-dimethyl-4-amino. -5-pyrazolone and (iv) N-ethyl-N- (2-hydroxy-3-sulfopropyl) -3,5-dimethylaniline, mixed salt of sodium salt, monohydrate (MAOS), or glucose dehydrogenase A mixed reagent of (GDH) with a tetrazolium salt and an electron mediator, and the like can be mentioned. In addition, buffering agents such as phosphate buffer may be included. The type and components of the coloring reagent 22 are not limited to these.

<Component Measurement Device 1>
Next, the component measuring device 1 will be described. The component measuring device 1 includes, for example, a housing 10 made of a resin material, a button group provided on the upper surface of the housing 10, liquid crystal provided on the upper surface of the housing 10, an LED (abbreviation of Light Emitting Diode), etc. And a display unit 11. The button group of the present embodiment is configured by the power button 13 and the operation button 14.

  As shown in FIGS. 1 to 3, the housing 10 is formed in a flat shape, and the thickness direction B of the housing 10 (same as the thickness direction A in a state where the component measurement chip 2 is attached to the component measurement device 1 In a top view (see FIG. 1) viewed from the top side of the direction), it has a substantially rectangular outer shape. Further, as shown in FIGS. 1 to 3, the housing 10 is divided into a gap-like chip mounting space S opened outward. Specifically, the housing 10 defines a gap-like chip mounting space S communicating with the outside through the opening of the side end surface located in the direction orthogonal to the thickness direction B. The height H of the chip mounting space S of the present embodiment is substantially uniform throughout the chip mounting space S. Moreover, the thickness T of the part accommodated in at least the chip mounting space S in the component measurement chip 2 of the present embodiment has a size slightly smaller than the height H of the chip mounting space S.

  When mounting the component measuring chip 2 to the component measuring device 1, the component measuring chip 2 is inserted into the chip mounting space S through the opening formed on the side end surface of the housing 10 from the outside. When the component measuring chip 2 is moved to a predetermined mounting position with respect to the component measuring device 1, the component measuring device 1 is in a state in which the component measuring chip 2 is locked. Thus, the attachment of the component measuring chip 2 to the component measuring device 1 is completed. In other words, the component measuring chip 2 is attached to the component measuring device 1 by being in such a locked state. Details of the mounting method of the component measuring chip 2 with respect to the component measuring device 1 and details of the locking state between the component measuring device 1 and the component measuring chip 2 will be described later (see FIG. 6, FIG. 7 etc.).

  The display unit 11 displays, for example, information of the measured component measured by the component measuring device 1. In the present embodiment, the glucose concentration (mg / dL) measured by the blood glucose level measuring device as the component measuring device 1 can be displayed on the display unit 11. Not only the information of the component to be measured but also various information such as the measurement condition of the component measuring device 1 and the instruction information for instructing the user to perform a predetermined operation may be displayed on the display unit 11. The user can operate the power button 13 and the operation button 14 of the button group while checking the content displayed on the display unit 11.

  Here, FIG. 5 is an electrical block diagram of the component measuring device 1 shown in FIGS. 1 to 3. For convenience of explanation, FIG. 5 also shows the cross section (the same cross section as FIG. 2) of the component measuring chip 2 in a state of being mounted on the component measuring device 1.

  As shown in FIG. 5, the component measuring device 1 includes an arithmetic unit 60, a memory 62, and a power circuit 63 in addition to the housing 10 (see FIG. 1), the display 11, the power button 13 and the operation button 14 described above. And a measurement optical system 64.

  The so-called colorimetric component measuring apparatus 1 irradiates light toward a reactant generated by the color reaction of the component to be measured in the body fluid and the coloring reagent 22, and detects the transmitted light quantity (or the reflected light quantity) To obtain a detection signal that correlates to the intensity of coloring according to the concentration of the component to be measured. And the component measuring apparatus 1 can measure a to-be-measured component by referring the calibration curve created beforehand. The component measuring device 1 of the present embodiment measures the glucose concentration (mg / dL) of the plasma component in blood as described above, and in the component measuring device 1 of the present embodiment, the display unit 11 and the power supply The measurement of glucose concentration is realized by the button 13, the operation button 14, the calculation unit 60, the memory 62, the power supply circuit 63, and the measurement optical system 64 cooperating with one another.

  The arithmetic unit 60 is configured by an MPU (Micro-Processing Unit) or a CPU (Central Processing Unit), and can realize control operation of each unit by reading and executing a program stored in the memory 62. The memory 62 is composed of a non-transitory storage medium that is volatile or non-volatile, and can read or write various data including a component measurement program necessary to execute the component measurement method shown here. . The power supply circuit 63 supplies power to each unit in the component measuring device 1 including the calculation unit 60 or stops the supply in response to the operation of the power button 13.

  The measurement optical system 64 is an optical system capable of acquiring optical characteristics of a reaction product generated by a color reaction of blood as a body fluid and the coloring reagent 22 as a reagent. Specifically, the measurement optical system 64 includes a light emitting unit 66, a light emission control circuit 70, a light receiving unit 72, and a light reception control circuit 74.

  As shown in FIG. 2, inside the housing 10 of the component measuring device 1, a first space 41, which communicates with the chip mounting space S and in which the light emitting portion 66 is accommodated, is formed. Further, as shown in FIG. 2, inside the housing 10 of the component measuring device 1, a second space 42 communicating with the chip mounting space S and in which the light receiving portion 72 is accommodated is formed. When the component measuring chip 2 is not accommodated in the chip mounting space S of the component measuring device 1, the first space 41 and the second space 42 face each other across the chip mounting space S, and the component measuring chip 2 In a state where 2 is accommodated in the chip mounting space S of the component measuring device 1, the first space 41 and the second space 42 hold the coloring reagent 22 as the reagent of the component measuring chip 2. The holding position and the space 28 are opposed to each other (see FIG. 2).

  The light emitting unit 66 according to this embodiment includes a first light emitting element 66a that emits light having a first wavelength, and a second light emitting element 66b that emits light having a second wavelength that is different from the first wavelength. including. Here, the first wavelength is a measurement wavelength for measuring the degree of color development according to the amount of blood sugar, and is, for example, in a wavelength band of 600 to 900 nm. The second wavelength is a wavelength for measuring the concentration of red blood cells in blood, for example, in a wavelength band of 510 to 590 nm.

  In the present embodiment, light emitting diodes (LEDs) are used as the first light emitting element 66a and the second light emitting element 66b, but a halogen lamp, a laser or the like may be used. When a halogen lamp is used as the light emitting portion, a spectral filter may be provided to extract only a specific wavelength. In addition, a condensing lens may be provided in order to effectively carry out irradiation with low energy.

  The light receiving portion 72 of the present embodiment is irradiated from the first light emitting element 66a, and is irradiated from the first light receiving element 72a that receives transmitted light passing through the component measurement chip 2 and the second light emitting element 66b. And a second light receiving element 72 b that receives the transmitted light that transmits the measurement chip 2. For example, a photodiode (PD) can be used as the first light receiving element 72a and the second light receiving element 72b. The light receiver 72 may convert the received light into a predetermined signal, and may use a CCD, a CMOS, or the like.

  The light emission control circuit 70 turns on the first light emitting element 66 a and the second light emitting element 66 b by supplying driving power signals to the first light emitting element 66 a and the second light emitting element 66 b of the light emitting unit 66. Or turn off. The light reception control circuit 74 performs logarithmic conversion and A / D conversion on the analog signal output from the light receiving unit 72 to obtain a detection signal which is a digital signal.

  In the component measuring device 1, the light emitted from the light emitting unit 66 is emitted to the reactant generated at the holding position of the coloring reagent 22 of the component measuring chip 2 and the position of the gap 28. Among the irradiated light, the transmitted light transmitted through the component measurement chip 2 in the thickness direction A is received by the light receiving unit 72, and the absorbance of the reaction product is measured. The calculation unit 60 calculates the glucose concentration using the measured absorbance of the reaction product using the calibration curve data stored in the memory 62, the data of the red blood cell concentration, and the like.

  Hereinafter, further features of the component measuring device set 100 will be described.

<First uneven portion 50a and second uneven portion 50b>
The component measuring chip 2 and the component measuring device 1 have a plurality of convex and concave portions which are engaged so as to maintain the relative position of the component measuring chip 2 to the component measuring device 1 at a predetermined mounting position. It is provided. The "predetermined mounting position" means the relative position of the component measuring chip 2 to the component measuring device 1 which allows the component measuring device 1 to measure the optical characteristics of the measured component in the component measuring chip 2. ing. Hereinafter, the details of the plurality of uneven portions will be described.

  The component measuring device set 100 of the present embodiment includes two uneven portions as a plurality of uneven portions.

  The first uneven portion 50a, which is the first uneven portion, is provided on one of the component measuring chip 2 and the component measuring device 1 in a state where the component measuring chip 2 is at a predetermined mounting position. A first convex portion 51 a that protrudes in the direction A, and a first concave portion 52 a that is provided on the other side and in which the first convex portion 51 a is fitted. Specifically, the first uneven portion 50a of the present embodiment is formed on the component measurement chip 2 which is fitted to the first convex portion 51a formed in the component measuring device 1 and the first convex portion 51a. And the first concave portion 52a.

  More specifically, the first uneven portion 50a of the present embodiment is formed on the surface facing the component measurement chip 2 in the thickness direction A among the inner walls that define the chip mounting space S of the component measurement device 1, and the chip mounting It is comprised by the projection part as the 1st convex part 51a which protrudes in thickness direction A in space S, and the hole as the 1st crevice 52a penetrated in the thickness direction A of ingredient measurement chip 2. The configuration of the first recess 52 a is not limited to the hole shown in the present embodiment, and may be, for example, a recess formed on one outer surface in the thickness direction A so as not to penetrate in the thickness direction A.

  The second uneven portion 50b, which is the second uneven portion, is formed in the component measuring device 1 to be fitted with the second convex portion 51b formed on the component measurement chip 2 and the second convex portion 51b. And a second concave portion 52b. More specifically, when the component measurement chip 2 is viewed in the thickness direction A, the second uneven portion 50b of the present embodiment is an outer edge convex portion as the second protrusion 51b formed on the outer edge of the component measurement chip 2 And an inner wall recess as a second recess 52b formed on the inner wall of the tip mounting space S capable of containing the component measuring chip 2 of the component measuring device 1 and capable of receiving an outer edge protrusion as the second protrusion 51b. It is configured.

  The outer edge convex portion as the second convex portion 51b has a shape in which the width W1 gradually decreases from the proximal end toward the distal end. Further, the inner wall concave portion as the second concave portion 52b can receive the outer peripheral convex portion as the second convex portion 51b, and has a shape in which the width W2 gradually decreases toward the concave bottom. Then, in the present embodiment, when the outer edge convex portion as the second convex portion 51b is inserted until the tip end abuts on the concave bottom of the inner wall concave portion as the second concave portion 52b, as shown by a broken line in the top view of FIG. Then, the entire outer wall of the outer peripheral convex portion is fitted so as to abut on the entire concave wall of the inner wall recess.

  Thus, the component measuring device set 100 has a plurality of (two in the present embodiment) uneven portions (in the present embodiment, the first uneven portion 50a and the second uneven portion 50b). Here, the component measuring chip 2 is attached to the component measuring device 1 so as to be a predetermined mounting position where the component to be measured can be measured by the component measuring device 1. The component measuring chip 2 is attached to the convex portion and the concave portion (in the present embodiment, the first convex portion 51 a and the first concave portion 52 a, and the second convex portion 51 b and the second concave portion 52 b) It fits when it mounts | wears with the component measuring apparatus 1 so that it may become a position. Therefore, in a state where the component measurement chip 2 is in the mounting position, the position of the component measurement chip 2 with respect to the component measurement device 1 can be stably maintained by fitting the convex portions and the concave portions of the plurality of uneven portions. it can.

  More specifically, in the present embodiment, the protrusion as the first protrusion 51 a of the first uneven portion 50 a and the hole as the first recess 52 a are fitted. Temporarily, in a state where the first uneven portion 50a is fitted, between the component measuring chip 2 and the component measuring device 1 in the circumferential direction centering on the first uneven portion 50a in top view (see FIG. 1) When there is a slight gap, the component measurement chip 2 is rotated in the circumferential direction centering on the first uneven portion 50a in top view (see FIG. 1) only by fitting of the first uneven portion 50a. obtain. On the other hand, in the present embodiment, since the outer peripheral convex portion as the second convex portion 51b of the second concave and convex portion 50b and the inner wall concave portion as the second concave portion 52b are fitted, the component measuring chip 2 is a component measuring device Even if it is attempted to rotate in the circumferential direction about the first uneven portion 50a in a top view (see FIG. 1) relative to 1, the outer peripheral convex portion as the second convex portion 51b and the inner wall concave portion as the second concave portion 52b And abut. Thereby, rotation of the component measuring chip 2 with respect to the component measuring device 1 can be restricted.

  That is, since the position of the component measurement chip 2 is restricted by the plurality of uneven portions (in the present embodiment, the first uneven portion 50a and the second uneven portion 50b) at the mounting position, the position is measured by only one uneven portion. The position at the mounting position of the component measurement chip 2 can be more stably maintained as compared with the configuration in which

  Further, as shown in FIG. 1, when the component measuring device set 100 of the present embodiment is viewed from the thickness direction A of the component measuring chip 2 in a state where the component measuring chip 2 is at a predetermined mounting position, The parts are located on both sides of the flow path 23. Specifically, the first uneven portion 50a of the present embodiment is located on the opposite side to the second uneven portion 50b across the flow path 23 in the top view of FIG. As described above, if the plurality of concavo-convex portions are disposed so as to sandwich the flow path 23, the component measurement chip 2 can be compared with the configuration in which the plurality of concavo-convex portions are disposed so as not to sandwich the flow path 23. It is easy to improve the position accuracy of the flow path 23 with respect to the component measuring device 1 when mounted on the. The flow path 23 in the present embodiment is a measurement position of the component to be measured by the component measuring device 1. Therefore, by improving the position accuracy of the flow path 23 with respect to the component measuring device 1, the measurement accuracy of the component to be measured can be further improved.

  Furthermore, when the component measuring device set 100 is viewed from the thickness direction A of the component measuring chip 2 with the component measuring chip 2 in the predetermined mounting position, the component measuring chip 2 is more as a reagent than a plurality of uneven portions. The grip portion 29 is provided at a position apart from the color developing reagent 22 of More specifically, the grip portion 29 of the present embodiment is orthogonal to the short direction of the component measurement chip 2 which is the extending direction of the flow path 23 in the top view of the component measurement chip 2 (see FIG. 4) In the longitudinal direction (vertical direction in FIG. 4), one side where the first uneven portion 50a is positioned with respect to the flow path 23, and in the same longitudinal direction. It is formed at a position farther from the flow path 23 than the first uneven portion 50a. Therefore, the user can handle the component measurement chip 2 in a state in which the grip portion 29 is gripped at a position away from the flow path 23, not near the flow path 23. Thereby, the user does not have to touch the vicinity of the measurement position of the flow path 23 where the light is emitted from the light emitting unit 66 (see FIG. 2 etc.) of the component measuring chip 2 in the component measuring chip 2. Therefore, it is possible to suppress the decrease in measurement accuracy due to unintended hand oil or the like.

  In particular, as shown in FIG. 1 and FIG. 3, the gripping portion 29 of the present embodiment is outward from the housing 10 of the component measuring device 1 even when the component measuring chip 2 is mounted at a predetermined mounting position. It is in a state of protruding. That is, by holding and operating the holding portion 29, the component measurement chip 2 is easily inserted into the component measuring device 1 to the mounting position where the first uneven portion 50a and the second uneven portion 50b fit together. can do. The gripping portion 29 may have a concavo-convex shape on the outer wall so that the user can easily grip.

  It is preferable to provide especially such a holding part 29 in the component measuring apparatus 1 using what is called "colorimetry". In an electrode-type component measuring device as a comparative example using a so-called "electrode method", an electrode-type component measuring chip as a comparative example in which an electrode is embedded is used. When this "electrode method" is used, it is connected so that the electrical contact of the electrode type component measuring device and the electrode of the electrode type component measuring chip are in contact with each other, and the body fluid is connected to the electrode type component measuring chip Two points of contact with the electrode may be realized, and high positional accuracy of the relative position of the electrode-type component measurement chip to the electrode-type component measurement device is not required. Further, when the body fluid and the electrode are brought into contact with each other, the component to be measured in the body fluid can be measured relatively stably. From these things, the electrode-type component measurement chip for the electrode-type component measurement device using the so-called "electrode method" has few limitations on handling such as holding manner and position for users such as patients and medical workers. , Easy to handle.

  On the other hand, in the case of the component measuring chip 2 used in the component measuring device 1 using the so-called "colorimetric method" as in this embodiment, if the user's hand oil etc. adhere to the portion to be measured, It greatly affects the transmission and reflection of light, and measurement errors of measurement components are likely to occur. Further, in order to make it possible to measure the optical characteristics, it is necessary to mount the part to be measured to the inside which becomes the dark part that can be measured by the measurement optical system 64 of the component measuring device 1. Therefore, in the component measuring chip 2 used for the component measuring device 1 utilizing a so-called "colorimetric method", it is desirable to provide the gripping portion 29 as in this embodiment.

  As in the component measurement chip 2 of the present embodiment, it is preferable to form the grip portion 29 at one end in the longitudinal direction, with the short direction of the component measurement chip 2 as the extending direction of the flow path 23. In this way, the grip portion 29 can be provided without lengthening the flow path 23. That is, the gripping portion 29 can be provided without increasing the amount of sample required for measurement.

  Next, details of the procedure for mounting the component measurement chip 2 on the component measurement device 1 will be described.

  Each of FIG. 6 and FIG. 7 is a figure which shows the outline | summary of the mounting method with respect to the component measuring apparatus 1 of the component measuring chip 2 of this embodiment. The component measurement chip 2 of the present embodiment can be attached to the component measurement device 1 by any of the attachment methods shown in FIGS. 6 and 7.

  6 moves the component measurement chip 2 in the longitudinal direction of the top view with the outer edge convex portion as the second convex portion 51b at the top (see the white arrow in FIG. 6), in the chip mounting space S The mounting method to insert is shown.

  In this mounting method, the component measuring chip 2 is inserted into the chip mounting space S while sliding the end face on one side of the component measuring chip 2 in the width direction to the inner wall defining the chip mounting space S. When the tip of the second convex portion 51 b is inserted until it abuts on the concave bottom of the second concave portion 52 b, the mounting position of the component measuring chip 2 to the component measuring device 1 is obtained. Further, when the component measurement chip 2 reaches the mounting position, each of the first uneven portion 50a and the second uneven portion 50b is fitted. As a result, the component measurement chip 2 is locked to the component measurement device 1 at the mounting position.

  FIG. 7 shows one end where the second convex portion 51b is located with the position of the second convex portion 51b as the center after inserting the outer peripheral convex portion as the second convex portion 51b of the component measurement chip 2 into the second concave portion 52b. The mounting method is shown in which the component measurement chip 2 is inserted into the chip mounting space S by rotating the other end in the longitudinal direction opposite to the portion (see the white arrow in FIG. 6).

  In this mounting method, the second concave portion 52 b is caused to slide the outer peripheral convex portion as the second convex portion 51 b formed at one end portion in the longitudinal direction of the component measurement chip 2 on the inner wall which divides the chip mounting space S. I will insert it inside. Furthermore, in this mounting method, the other end in the longitudinal direction is rotated around the second convex portion 51b simultaneously with the sliding movement of the second convex portion 51b described above (see the white arrow in FIG. 7). , Inserted into the chip mounting space S.

  In other words, the second uneven portion 50b of this embodiment measures the component so that the first uneven portion 50a as another uneven portion is engaged when the component measurement chip 2 is attached to the component measuring device 1. It also serves as a guide for guiding the movement of the chip 2 with respect to the component measuring device 1.

  More specifically, as shown in FIG. 7, the distal end 51b1 of the outer peripheral convex portion as the second convex portion 51b is a concave wall 52b1 on the back side (upper side in FIG. 7) partitioning the inner wall concave portion as the second concave portion 52b. When sliding toward the concave bottom of the inner wall recess, the outer wall 51b2 on the front side (lower side in FIG. 7) of the outer edge convex portion is moved to the inner wall recess before the tip 51b1 reaches the concave bottom. It strikes against concave wall 52b2 of the near side which it divides. Therefore, when attempting to further move the tip 51b1 toward the concave bottom, the outer wall 51b2 on the front side of the outer edge convex portion is pressed to the back side by the front concave wall 52b2 that divides the inner wall concave portion. That is, the other end side in the longitudinal direction of the component measuring chip 2 is pressed to the back side so as to enter the chip mounting space S of the component measuring device 1. If the component measuring chip 2 is rotated relative to the component measuring device 1 according to this pressing force, the component measuring chip 2 can be inserted to the mounting position. That is, the component measurement chip 2 can be moved to a position where the first uneven portion 50a and the second uneven portion 50b are fitted.

  As described above, when at least one uneven portion is configured as a guide for guiding to a position where another uneven portion engages, the component to the mounting position of the component measurement chip 2 in which each of the plurality of uneven portions is fitted It becomes possible to easily move the measuring chip 2 with respect to the component measuring device 1.

  Further, the second convex portion 51 b of the second uneven portion 50 b of the present embodiment is formed at a position corresponding to the short side on one side of the component measurement chip 2 having a substantially rectangular shape in top view. Furthermore, the second convex portion 51 b is formed at one end of the short side in the short side direction. Therefore, in the top view (see FIG. 4), the component measurement chip 2 of the present embodiment is asymmetric on both sides in the longitudinal direction and is also asymmetric on both sides in the lateral direction. By making the component measuring chip 2 into such an asymmetrical outer shape, it is possible to suppress a mistake in the insertion direction of the component measuring chip 2 with respect to the component measuring device 1, and as a result, mounting error of the component measuring chip 2 with respect to the component measuring device 1 It can be suppressed.

  As described above, since the component measuring device set 100 includes the plurality of uneven portions (in the embodiment, the first uneven portion 50a and the second uneven portion 50b), the position is regulated only by one uneven portion. As compared with the configuration, it is possible to improve the positional accuracy of the mounting position of the component measuring chip 2 with respect to the component measuring device 1 using the so-called "colorimetry".

  Although the 1st uneven part 50a of this embodiment is constituted by the 1st convex part 51a provided in ingredient measuring device 1, and the 1st crevice 52a provided in ingredient measuring chip 2, it is set to this composition. The present invention is not limited to this, and the first uneven portion may be configured by the concave portion provided in the component measuring device and the convex portion provided in the component measuring chip.

  The component measuring apparatus 1 using so-called “colorimetry” is required to have relatively high accuracy in the distance relationship and positional relationship between the members constituting the measuring optical system 64, and the measuring optical system 64 and the component measuring chip 2 Also in the distance relation and the positional relation, fluctuation due to the individual component measurement chips leads to a decrease in measurement accuracy, which is not preferable. Providing the component measuring chip with a convex portion protruding in the thickness direction A with respect to the component measuring chip makes it easy to thicken the component measuring chip, but has the advantage that it is easy to control the dispersion of the optical path length on the component measuring device side . In this case, a component measuring chip having a convex portion on at least one side in the thickness direction A is manufactured by a flexible member, and the convex portion is deformed when the component measuring chip 2 is inserted into the component measuring device 1. The convex portion may be restored at the completion position. On the other hand, in order to measure the component to be measured with high accuracy by the component measuring device 1 without increasing the amount of sample, it is desirable to narrow the gap of the chip mounting space S. Furthermore, it is desirable to be able to stably prepare a thin component measuring chip with a predetermined thickness in accordance with the configuration of the measuring optical system 64. Therefore, as in the present embodiment, it is particularly preferable to use the component measurement chip 2 in which the first recess 52a is formed. If it is a hole like the 1st crevice 52a of this embodiment, if a hole penetrated to thickness direction A is formed, it is possible to create easily.

  Moreover, as a structure of the convex part which comprises a 1st uneven | corrugated part, although columnar shapes, such as a cylinder and a square note, may be sufficient, like the 1st convex part 51a of the 1st uneven part 50a shown in FIG. It is preferable to use a shape having a tapered side surface whose diameter decreases from the proximal end to the top, such as a hemispherical shape, a conical shape such as a cone or a pyramid, or a frustum shape. Further, like the first recess 52 a of the present embodiment, the recess has an edge portion whose inner diameter is smaller than the outer diameter at the base end of the protrusion corresponding to the protrusion having the above-described tapered side surface. Is preferred.

  In this way, as shown in FIG. 3, the top of the first protrusion 51a enters the first recess 52a, and the tapered side surface of the first protrusion 51a is the edge of the first recess 52a. The first uneven portion 50a can be fitted to press. Thereby, the component measurement chip 2 is pressed toward one side in the thickness direction A. As a result, the component measurement chip 2 is positioned in the chip mounting space S while being pressed toward the inner wall that divides the chip mounting space S located on one side in the thickness direction A (the lower side in FIG. 3). Is regulated. In this way, it is possible not only to make the component measurement chip 2 difficult to move in the thickness direction A within the chip mounting space S, but also to separate the component measurement chip 2 from the component measurement chip 2 It can be made difficult to move also in the direction orthogonal to the thickness direction A by the frictional force with the inner wall and the like. That is, if the first uneven portion having a shape like the first uneven portion 50a of the present embodiment is used, the position regulation performance of the component measurement chip 2 with respect to the component measurement device 1 can be enhanced.

  In addition, the second uneven portion 50b of the present embodiment is configured by the second convex portion 51b provided in the component measurement chip 2 and the second concave portion 52b provided in the component measurement device 1, Not limited to the configuration, the second uneven portion may be configured by the convex portion provided in the component measuring device and the concave portion provided in the component measuring chip.

  Furthermore, the second uneven portion 50b of the present embodiment is an outer edge convex portion as a second convex portion 51b formed to protrude outward at the outer edge of the component measurement chip 2 in top view (see FIG. 1). And the inner wall concave portion as the second concave portion 52 b formed on the inner wall of the chip mounting space S, but the present invention is not limited to this structure. For example, the second uneven portion may have the same configuration as that of the first uneven portion 50a. However, as in the present embodiment, it is preferable to configure the second uneven portion 50 b with the outer edge convex portion as the second convex portion 51 b and the inner wall concave portion as the second concave portion 52 b. In this way, as described above, the movement of the component measurement chip 2 is guided such that the first uneven portion 50a as another uneven portion engages, or the component of the component measurement chip 2 is asymmetrical due to the asymmetrical outer shape It is possible to suppress mounting errors with respect to the measuring device 1.

  Here, FIG. 8 and FIG. 9 are diagrams showing a modification of the second uneven portion 50b in the present embodiment. FIG. 8 shows a second convex portion 51b 'of the component measuring chip 2' and a second concave portion 52b 'of the component measuring device 1' as a modification of the second uneven portion 50b. Moreover, FIG. 9 shows 2nd convex part 51b '' of component measurement chip | tip 2 '' and 2nd recessed part 52b '' of component measurement apparatus 1 '' as another modification of 2nd uneven part 50b. Each of FIG. 8 and FIG. 9 is a top view in the vicinity of the second uneven portion of the component measuring chip, and in FIG. 8 and FIG. 9, for convenience of explanation, the shape of the component measuring chip located in the component measuring device is broken It shows.

  In 2nd convex part 51b 'shown in FIG. 8, the outer wall 51b2' of the near side is curving in circular arc shape. If the outer wall 51b2 'is curved in an arc shape like this, the component measuring chip 2' is attached to the component measuring device 1 'by the same attaching method as the above-described attaching method described with reference to FIG. In this case, it is possible to guide the component measurement chip 2 'to the mounting position while rotating the component measurement chip 2' more smoothly as compared to the case of adopting the configuration of the second convex portion 51b of the present embodiment. As shown in FIG. 8, in the case where the outer wall 51b2 'is curved in a circular arc, the concave wall 52b2' on the front side of the second recess 52b 'also has a concave curvature corresponding to the shape of the outer wall 51b2'. It is preferable to use a shape. In this way, the rotation of the component measurement chip 2 'can be guided more smoothly.

  In the second convex portion 51b ′ ′ shown in FIG. 9, a notch 53 ′ ′ is formed in the root portion of the outer wall 51b2 ′ ′ on the front side. Further, the component measuring chip 2 ′ ′ is attached to the component measuring device 1 ′ ′ at the edge portion of the concave wall 52b2 ′ ′ on the front side of the second concave portion 52b ′ ′ of the component measuring device 1 ′ ′ shown in FIG. In this case, a claw 54 ′ ′ is formed which slides over the outer wall 51b2 ′ ′ and slides over the outer wall 51b2 ′ ′ to fit into the notch 53 ′ ′ with the component measurement chip 2 ′ ′ attached. If it is set as the structure which has such notch part 53 '' and nail | claw part 54 '', the structure of the 2nd convex part 51b and 2nd recessed part 52b of this embodiment which does not have notch part 53 '' and nail | claw part 54 ''. The position control of the component measuring chip 2 ′ ′ with respect to the component measuring device 1 ′ ′ at the mounting position can be made more rigid than in the case of adopting. That is, it is possible to further improve the positional accuracy at the mounting position of the component measurement chip 2 ′ ′.

  As described above, by providing the plurality of uneven portions in the component measuring device set, it is possible to improve the position accuracy of the component measuring chip with respect to the component measuring device.

  In other words, in the present embodiment, the convex formed on the component measuring device 1 such that the component measuring chip 2 mounted on the component measuring device 1 maintains the relative position to the component measuring device 1 at the predetermined mounting position. A recess (in the present embodiment, the first protrusion 51a) and a recess (in the present embodiment, the first recess 52a), and a recess formed in the component measuring device 1 (the second recess 52b in the present embodiment) By providing the engaging convex portion (the second convex portion 51b in the present embodiment), the positional accuracy of the component measuring chip 2 at the mounting position with respect to the component measuring device 1 can be enhanced.

  As the component measuring chip, a concave portion engaged with a convex portion formed in the component measuring device or a concave portion formed in the component measuring device so as to maintain the relative position to the component measuring device at a predetermined mounting position A plurality of mating convex portions may be provided. Even with such a configuration, it is possible to enhance the positional accuracy of the component measuring chip at the mounting position with respect to the component measuring device. Furthermore, in order to increase the stability at the mounting position of the component measurement chip, a configuration may be added in which the component measurement chip is biased and held by a plate spring or the like.

  The plurality of concavo-convex portions of the component measuring device set can be realized by various configurations, and are not limited to the specific configurations shown in the present embodiment and the above-described modified example. Therefore, for example, it is possible to make the position, size, and number of the plurality of uneven portions different according to the component to be measured. For example, as shown in FIG. 10, a first component measurement chip 81 for glucose concentration measurement, a second component measurement chip 82 for uric acid concentration measurement, and lactic acid concentration that can be attached to the same component measurement device 80 The third component measurement chip 83 for measurement can be prepared, and the position, size, and number of the plurality of uneven portions in each component measurement chip can be made different. In the example shown in FIG. 10, the first convex portion 510a and the first concave portion 520a of the first uneven portion of each component measurement chip are common, and the position of the second uneven portion is different. The positions of both the portion and the second uneven portion may be different. Further, the sizes of the first uneven portion and the second uneven portion may be different. Furthermore, the number of uneven portions may be different.

  More specifically, the first component measurement chip 81 shown in FIG. 10 includes the second convex portion 510b1. Further, the component measuring device 80 shown in FIG. 10 is provided with a second concave portion 520b1 for the first component measuring chip in which the second convex portion 510b1 of the first component measuring chip 81 is fitted.

  Further, the second component measurement chip 82 shown in FIG. 10 includes a second convex portion 510b2. Further, the component measuring device 80 shown in FIG. 10 is provided with a second concave portion 520b2 for the second component measuring chip in which the second convex portion 510b2 of the second component measuring chip 82 is fitted.

  Furthermore, the third component measuring chip 83 shown in FIG. 10 includes a second convex portion 510b3. Further, the component measuring device 80 shown in FIG. 10 is provided with a second concave portion 520b3 for the third component measuring chip in which the second convex portion 510b3 of the third component measuring chip 83 is fitted.

  Then, the component measuring device 80 is in a state where the component measuring chip of any one of the first component measuring chip 81, the second component measuring chip 82 and the third component measuring chip 83 is at the mounting position with respect to the component measuring device 80. Second convex portion 510b1 formed on the first component measuring chip 81, second convex portion 510b2 formed on the second component measuring chip 82, and second convex portion formed on the third component measuring chip 83 A detection unit 85 that detects any position 510b3 is provided. As a result, the component measuring device 80 can detect the type and the like of the component to be measured which can be measured by the mounted component measuring chip.

  The component measuring device 80 sets measurement conditions for measuring the component to be measured according to the detection value of the detection unit 85. For example, various measurement conditions are set differently depending on whether the measurement target is any of glucose concentration, uric acid concentration, and lactic acid concentration. As various measurement conditions, for example, various information determined according to the measurement object such as calibration information according to the measurement object, reaction time of the color reaction, etc. is set.

  Although in FIG. 10, the position, size, and number of the plurality of concavo-convex portions are different according to the measurement object, the present invention is not limited to the difference of the component to be measured. The component information of the reagent can be used to identify various differences in the component measurement chip.

  The component measuring device set and the component measuring chip according to the present invention are not limited to the specific configurations described in the above-described embodiment and modifications, and various modifications can be made without departing from the scope of the claims.

  The present disclosure relates to a component measurement device set and a component measurement chip.

1, 1 ′, 1 ′ ′: component measuring device 2, 2 ′, 2 ′ ′: component measuring chip 10: housing 11: display unit 13: power button 14: operation button 21: base member 22: coloring reagent (reagent)
23: flow path 24: supply portion 25: cover member 27: spacer member 28: gap 29: grip portion 41: first space 42: second space 50a: first uneven portion 50b: second uneven portion (guide portion )
51a: 1st convex part (protrusion part)
51b, 51b ', 51b'': second convex portion (outer rim convex portion)
51 b 1: tip 51 b 2, 51 b 2 ′, 51 b 2 ′ ′: outer wall 52 a: first recess (recessed portion or hole)
52b, 52b ', 52b'': second recess (inner wall recess)
52b1: Back side concave wall 52b2, 52b2 ′, 52b2 ′ ′: front side concave wall 53 ′ ′: notch 54 ′ ′: claw portion 60: calculation unit 62: memory 63: power supply circuit 64: measurement optical system 66 : Light emitting unit 66a: first light emitting device 66b: second light emitting device 70: light emitting control circuit 72: light receiving unit 72a: first light receiving device 72b: second light receiving device 74: light receiving control circuit 80: component measuring device 81: first component measurement chip 82: second component measurement chip 83: third component measurement chip 85: detection unit 100: component measurement device set 510a: first convex portion 510b1: second convex portion 510b2 of first component measurement chip : Second convex portion 510b3 of the second component measuring chip: second convex portion 520a of the third component measuring chip: first concave portion 520b1: second concave portion 520b2 for the first component measuring chip: second for the second component measuring chip 2 recess 5 0b3: Second recess A for the third component measuring chip: thickness direction of the component measuring chip B: thickness direction of the housing H: height of the chip mounting space S: chip mounting space T: thickness of the component measuring chip W1: second Width of convex portion W2: width of second concave portion

Claims (9)

A component measurement chip having a reagent that causes a color reaction with a component to be measured in body fluid,
The component measuring device mounted on the component measuring chip and measuring the component to be measured based on optical characteristics of a reaction product obtained by a color reaction between the component to be measured and the reagent;
The component measuring chip and the component measuring device are provided with a plurality of concavo-convex portions including a convex portion and a concave portion engaged so as to maintain the relative position of the component measuring chip to the component measuring device at a predetermined mounting position. Component measuring device set. The component measurement chip defines a flow path in which the reagent is contained,
When viewed from the thickness direction of the component measurement chip with the component measurement chip in the predetermined mounting position, the plurality of concavo-convex portions are located on both sides sandwiching the flow path. Component measurement device set as described.   When viewed from the thickness direction of the component measurement chip in a state where the component measurement chip is at the predetermined mounting position, the component measurement chip is further separated from the reagent than the plurality of uneven portions. The component measuring device set of Claim 1 or 2 provided.   The movement of the component measuring chip relative to the component measuring device such that at least one uneven portion of the plurality of uneven portions is engaged with the other uneven portion when the component measuring chip is mounted on the component measuring device The component measuring device set according to any one of claims 1 to 3, further comprising: a guide portion for guiding the guide.   The at least one uneven portion is formed on the outer edge of the component measurement chip, and an outer edge convex portion having a shape whose width gradually decreases toward the tip, and a chip capable of accommodating the component measurement chip of the component measurement device The component measuring device set according to claim 4, comprising: an inner wall recess formed on the inner wall of the mounting space and having a shape whose width gradually decreases toward the concave bottom.   At least one uneven portion of the plurality of uneven portions is provided on one of the component measuring chip and the component measuring device in a state where the component measuring chip is at the predetermined mounting position, and the thickness direction of the component measuring chip The component measuring device set according to any one of claims 1 to 3, further comprising: a protruding portion protruding in the second direction; and a recessed portion provided on the other side and in which the protruding portion is fitted.   The convex portion of the at least one uneven portion is a protrusion formed on the component measuring device, and the concave portion of the at least one uneven portion is a recess or a hole formed in the component measuring chip The component measuring device set according to claim 6, which is a part. The component measuring device includes a detection unit that detects the position, size, or number of projections or recesses formed on the component measuring chip, with the component measuring chip in the predetermined mounting position.
The component measuring device set according to any one of claims 1 to 7, wherein a measurement condition for measuring the component to be measured is set according to a detection value of the detection unit. A component measuring device that has a reagent that causes a color reaction with a component to be measured in body fluid, and measures the component to be measured based on the optical characteristics of a reactant obtained by the color reaction of the component to be measured and the reagent. A component measurement chip attached to the
A concave portion engaged with a convex portion formed on the component measuring device and a convex portion engaged with a concave portion formed on the component measuring device so as to maintain the relative position to the component measuring device at a predetermined mounting position A unit, or
A concave portion engaged with a convex portion formed in the component measuring device or a convex portion engaged with a concave portion formed in the component measuring device so as to maintain the relative position to the component measuring device at a predetermined mounting position A plurality of parts, a component measurement chip.

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