JPWO2016166800A1 - Experimental data recording apparatus, computer program, experimental data, experimental data recording method, experimental data display apparatus, and experimental data display method - Google Patents

Abstract

An experimental data recording device (1) for recording experimental data that is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology fields, and receiving unit (21) for receiving an operation record of an experimental instrument And an experiment ID recording unit (12) for recording an experiment ID, which is an ID unique to the experiment, in association with a protocol ID unique to the protocol, and each of the received operation records of a plurality of procedures included in the protocol. Among them, an experimental data recording device (1) having an operation recording unit (25) for recording in association with a corresponding procedure.

Description

  The present invention relates to an experimental data recording device, a computer program, experimental data, an experimental data recording method, an experimental data display device, and an experimental data display method.

  In order to correctly evaluate the results of experiments in the fields of biochemistry, biology, biotechnology, etc. (referred to as a series of tests, cultures, and amplifications), the experiment requires preset procedures and conditions. It must be documented verifiably that it is done as expected. The work procedure and conditions in an experiment are generally called a protocol, and whether an experiment was correctly performed according to the protocol is determined by the experimenter depending on the description in their experiment notes. .

  The problem to be solved by the present invention is to record a record of an experiment based on a protocol with objectivity and high reliability.

  An experimental data recording apparatus according to an aspect of the present invention is an experimental data recording apparatus that records experimental data that is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology fields. The protocol includes a reception unit that receives an operation record, an experiment ID recording unit that records an experiment ID that is an experiment-specific ID in association with a protocol ID unique to a protocol, and the received operation record. An operation recording and recording unit for recording in association with the corresponding procedure among the plurality of procedures;

  The experiment data recording apparatus according to one aspect of the present invention further includes a target sample ID recording unit that records a target sample ID, which is an ID of a sample subjected to the experiment, in association with the experiment ID, and an experiment. And a result sample ID recording unit that records the result sample ID, which is the ID of the sample obtained as a result of the above, in association with the experiment ID.

  The experiment data recording apparatus according to one aspect of the present invention may further include an experiment environment data recording unit that records experiment environment data in association with the experiment ID.

  In the experimental data recording apparatus according to one aspect of the present invention, the experimental instrument may include an instrument directly operated by an experimenter.

  In the experimental data recording apparatus according to one aspect of the present invention, the experimental instrument may include an electric pipette.

  The experimental data recording apparatus according to one aspect of the present invention may further include an in-experiment protocol display unit that displays a protocol related to the experiment on the monitor during the experiment.

  In the experimental data recording apparatus according to one aspect of the present invention, the experimental instrument may include a robot that performs an experiment based on the protocol.

  The experiment data recording apparatus according to one aspect of the present invention may further include an experiment ID issuing unit that issues the experiment ID for each experiment.

  In the experiment data recording apparatus according to one aspect of the present invention, the experiment ID issuing unit may acquire an experiment ID generated by an external experiment ID generation apparatus.

  The experimental data recording apparatus according to an aspect of the present invention may further include a tampering prevention unit that performs tampering prevention processing on the experimental data.

  In the experimental data recording apparatus according to one aspect of the present invention, the tampering prevention unit may perform a tampering prevention process at least every time the operation recording is recorded by the operation recording unit.

  The experimental data recording device according to one aspect of the present invention may further include an experimental data storage unit that stores the obtained experimental data in an external experimental data storage device.

  The experiment data recording apparatus according to one aspect of the present invention further includes analysis data recording for recording analysis data, which is analysis result data for a sample obtained as a result of an experiment, in association with a result sample ID of the sample. May have a part.

  The experiment data recording apparatus according to one aspect of the present invention further corresponds to the protocol by associating the protocol display unit for displaying the protocol in which the experiment has been performed with each of the procedures included in the protocol. An operation record display unit for displaying an operation record included in the experimental data.

  A computer program according to another aspect of the present invention causes a computer to function as any of the above-described experimental data recording devices.

  The experimental data according to another aspect of the present invention is experimental data that is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology, and is associated with a protocol ID unique to the protocol. An experiment ID, which is an ID unique to the experiment, and an operation record of the laboratory instrument associated with the corresponding procedure included in the protocol.

  An experimental data recording method according to another aspect of the present invention is an experimental data recording method for recording experimental data that is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology fields. , Receiving an operation record of the experimental instrument, recording an experiment ID, which is an ID unique to the experiment, in association with a protocol ID unique to the protocol, and receiving each of the received operation records of a plurality of procedures included in the protocol Of these, it is recorded in association with the corresponding procedure.

  In addition, an experimental data display device according to another aspect of the present invention displays a protocol in which an experiment has been performed with respect to experimental data that is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology. A post-experiment protocol display section, and an operation record display section for displaying an operation record used in the experiment included in the experiment data corresponding to the protocol in association with each procedure included in the protocol. .

  The experimental data display device according to one aspect of the present invention may further include an analytical data display unit that displays analytical data corresponding to the experimental data.

  In addition, an experimental data display method according to another aspect of the present invention displays a protocol in which an experiment has been performed with respect to experimental data that is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology. Then, in association with each procedure included in the protocol, an operation record of the laboratory instrument used in the experiment included in the experiment data corresponding to the protocol is displayed.

It is a block diagram which shows the physical structure of the experimental data recording apparatus which concerns on embodiment of this invention. It is a functional block diagram of the experiment data recording device concerning the embodiment of the present invention. It is a figure which shows an example of a protocol. It is a conceptual diagram which shows the whole experiment system containing an experiment data recording device. It is a figure which shows an example of a mode that the experimental data is displayed superimposed on the protocol chart. It is a flowchart which shows the operation | movement which an experimental data recording device records experimental data. It is a flowchart which shows the operation | movement which an experimental data recording device superimposes and displays experimental data on a protocol chart. It is a functional block diagram of the experiment data recording device concerning the modification of the embodiment of the present invention. It is a functional block diagram of an experimental data display device.

  According to the viewpoint of the inventor of the present invention, the recording of the experiment by the experiment notebook has room for subjectivity and human error by the experimenter, and it takes a lot of time to verify the result for an important experiment. And labor may be required. In addition, seeking accurate and sufficient records in the experiment notebook is a burden on the experimenter and may reduce the work efficiency of the experiment and the productivity of the research activity itself.

  Therefore, the inventor of the present invention has invented a novel and original experiment data recording device, etc. as a result of earnest research and development on recording an experiment record based on a protocol with objectivity and high reliability. It came to do. Hereinafter, such an experimental data recording device and the like will be described in detail with reference to the drawings through the embodiment.

  FIG. 1 is a block diagram showing a physical configuration of an experimental data recording apparatus 1 according to an embodiment of the present invention. The experimental data recording device 1 itself may be a dedicated device, but here is realized using a general computer. That is, in a commercially available computer, the computer is used as the experimental data recording device 1 by executing a computer program that causes the computer to operate as the experimental data recording device 1. Such a computer program is generally provided in the form of application software, and is used by being installed in a computer. The application software may be provided by being recorded on an appropriate computer-readable information recording medium such as a CD-ROM, DVD-ROM, or may be provided through various information communication networks such as the Internet. Alternatively, it may be realized by so-called cloud computing in which the function is provided by a server at a remote place through an information communication network.

  The configuration shown in FIG. 1 shows a general computer used as the experimental data recording device 1, and includes a CPU (Central Processing Unit) 1a, a RAM (Random Access Memory) 1b, an external storage device 1c, and a GC (Graphics Controller). ) 1d, the input device 1e and the I / O (Input / Output) 1f are connected to each other via the data bus 1g so that electrical signals can be exchanged. Here, the external storage device 1c is a device capable of recording information statically, such as an HDD (Hard Disk Drive) or an SSD (Solid State Drive). The signal from the GC 1d is output to a monitor 1h such as a flat panel display where the user visually recognizes the image and displayed as an image. The input device 1e is a device for a user to input information, such as a keyboard, a mouse, and a touch panel, and the I / O 1f is an interface for the experimental data recording device 1 to exchange information with an external device.

  FIG. 2 is a functional block diagram of the experimental data recording apparatus 1 according to this embodiment. Note that the functional blocks shown here are shown paying attention to the functions of the experimental data recording apparatus 1 and do not necessarily have a physical configuration corresponding to each functional block. Some functional blocks are realized by an information processing device such as the CPU 1a of the experimental data recording apparatus 1 executing specific software, and some functional blocks are specific to an information storage device such as the RAM 1b of the experimental data recording device 1. This is realized by allocating a storage area.

  The experimental data recording apparatus 1 includes a protocol data storage unit 10 that stores protocol data that is electronic data indicating a protocol, and an experimental data storage unit 11 that stores experimental data, and stores experimental data obtained during an experiment. The data is recorded in association with protocol data indicating the protocol on which the experiment is based. Here, the protocol refers to work procedures and conditions such as pretreatment performed on samples in the fields of biochemistry, biology / biotechnology, etc., and the individual procedures included in the protocol are designated by specified conditions and order. It is described that a predetermined experiment is performed by performing the above. The protocol usually includes experiments in the field of biochemistry or biology / biotechnology (not limited to experiments in a narrow sense, but includes performing predetermined treatments on samples, reagents, samples, etc. in a specific procedure, and It is described so that an implementer or planner (including actions etc.) conducts experiments as planned or records / transmits the contents of experiments. Therefore, the protocol referred to here is not limited to a specific description format as long as it includes one or more work procedures as described above. Further, since the number, quality, contents, etc. of work procedures included in the protocol depend on the intention of the protocol creator, these are not limited. Furthermore, the technical field in which the protocol used here is not limited to biochemistry or bio / biotechnology, but in this specification, at least one of biochemistry and bio / biotechnology is included. And The protocol data includes a protocol ID, which is information for uniquely identifying the protocol, and procedure data indicating individual procedures included in the protocol. The experimental data refers to various information related to the experiment, such as the experiment itself, various conditions of the experiment, and operation records of various instruments used in the experiment. In particular, the experiment data includes an experiment ID, which is information for uniquely identifying the experiment itself, and operation records of various instruments used in the experiment.

  Note that the protocol data storage unit 10, the protocol server 32 described later, or both of them may store one or a plurality of protocol data associated with the protocol ID, and may specify the protocol data from the protocol ID. For example, it may have a function similar to a general database.

  The experimental data recording device 1 includes various recording units that record various information included in the experimental data during the experiment. When performing the experiment, the experiment ID recording unit 12 associates the experiment ID with the protocol ID and records the experiment ID in the experiment data storage unit 11. Specifically, this association indicates that the experiment specified by the experiment ID is based on the protocol specified by the protocol ID by including both the protocol ID and the experiment ID in the experiment data. Indicated. Note that the protocol data itself may be added to the experimental data. The experiment ID is issued by the experiment ID issuing unit 13 for each experiment.

  Note that the experiment data storage unit 11 or the experiment data storage device 26 described later, or both of them may also store one or a plurality of experiment data associated with the protocol ID and the experiment ID. It may have a function similar to a general database, such as being able to specify data or search experimental data from a protocol ID.

  The experiment ID issuing unit 13 may generate the experiment ID by itself, but acquires the experiment ID generated by the external experiment ID generating device 24 connected via the communication unit 20. May be. By installing the experiment ID generating device 24 as a web server that can communicate via an electric communication line such as the Internet in common to a plurality of experimental data recording devices 1, there is no duplication in different experimental data recording devices 1. The experiment ID can be issued uniquely. Alternatively, by giving a certain restriction to the experiment ID issued by the experiment ID issuing unit 13, for example, using an ID uniquely set in the experiment data recording device 1 as a part of the experiment ID, Uniqueness may be guaranteed. In any case, the experiment ID is issued as unique to each experiment, and various information included in the experiment data described below is recorded in association with this experiment ID. It will be clearly recorded whether it is information about.

  The experiment environment data recording unit 14 records the experiment environment data regarding the experiment in the experiment data storage unit 11 as experiment data. The experimental environment data is data indicating conditions for the experiment itself, and includes at least one of data indicating the experimenter, the experiment place, the experiment date and time, and the experimental instrument. The experimenter is information that identifies the person who directly performed the experiment or the person responsible for the experiment, and the experiment location is information that identifies the location of the building, room, booth number, etc. where the experiment was performed, This information specifies the date and time when the experiment was performed, and may include the start time of the experiment and the end time in addition to this. The data indicating the experimental instrument is information that identifies the experimental instrument used in the experiment. For example, as will be described later, when the experimental instrument is an electric pipette, a unique ID such as a serial number of the electric pipette corresponds to information for specifying the experimental instrument. When a plurality of experimental instruments are used, for example, when a plurality of electric pipettes are used, or when a microscope is used in addition to the electric pipettes, the IDs unique to each experimental instrument are all data indicating the experimental instruments, It may be included in the experimental environment data. The experimental environment data can also be used as important data indicating that the experiment has been carried out genuinely.

  The target sample ID recording unit 15 records the target sample ID, which is information for specifying the sample used in the experiment, in the experimental data storage unit 11 as experimental data. In addition, the result sample ID recording unit 16 stores the result sample ID, which is information for specifying the sample as a result of the experiment, obtained as a result of performing various operations on the sample used in the experiment as experiment data. Part 11 is recorded. Thereby, the target sample used for the experiment and the result sample obtained as a result of the experiment can be accurately specified. As the target sample ID and the result sample ID, for example, an ID indicating a container attached to a container such as a test tube or a Petri dish in which the sample is stored may be read by the reader 17 and used as the target sample ID or the result sample ID. .

  The operation record recording unit 18 records operation records of various instruments used in the experiment in the experiment data storage unit 11 as experiment data. Here, the operation record is a record of the operation of the experimental instrument 19 used in the experiment, and is received by the receiving unit 21 via the communication unit 20. A specific example of operation recording will be described later. Since the operation record records that each procedure included in the protocol is actually performed using a specific experimental instrument 19, the operation record recording unit 18 stores each of the operation records in the protocol. Record in association with the corresponding procedure data in the data. Thereby, it is possible to identify which procedure corresponds to each of the operation records included in the experimental data among the plurality of procedures included in the protocol.

  The analysis data recording unit 22 records, in the experiment data storage unit 11, analysis data, which is information obtained as a result of analyzing the result sample obtained after the experiment is completed by the external analyzer 23. At this time, in order to specify the sample analyzed by the analyzer 23, the analysis data recording unit 22 records the analysis data in association with the result sample ID. The analysis data may include information on the analysis environment, for example, an ID for identifying the analyzer used for the analysis, various analysis conditions, and information indicating the analysis date and time in addition to the information on the sample to be analyzed. . As a result, not only the fact of the experiment but also the obtained result can be evaluated based on the experimental data. Since the result sample ID is associated with the experiment ID, the analysis data is also associated with the experiment ID.

  The experimental data storage unit 25 stores the experimental data recorded by the various recording units described above and stored in the experimental data storage unit 11 in the external experimental data storage device 26 via the communication unit 20. When the experimental data storage device 26 is installed as a web server that can communicate via an electric communication line such as the Internet, the stored experimental data can be viewed from devices other than the experimental data recording device 1. Yes, and can be viewed from third parties other than the experimenter. In order to ensure the confidentiality of the experimental data and to restrict who can view it, the experiment data stored in the experimental data storage device 26 is given a password or a viewing restriction, and the corresponding viewing authority is granted. The viewing may be restricted to those who have it. In addition, the experiment data storage unit 25 may store the experiment data through the tampering prevention unit 33 so that the experiment data is appropriately tampered with. The falsification preventing unit 33 prevents falsification of electronic data by performing a known falsification preventing process on the experimental data, for example, by giving an electronic certificate or adding a hash value by a private hash function. This makes it possible to perform an artificial operation on the experimental data or to detect data corruption, thereby maintaining the reliability and accuracy of the experimental data.

  The communication unit 20 performs electrical communication between the experimental data recording device 1 and various external devices. The communication unit 20 is realized by the I / O 1f shown in FIG. 1, and it does not matter whether the communication is wired / wireless or the communication standard used. In particular, the communication unit 20 communicates with the experimental instrument 19 and causes the reception unit 21 to receive an operation record thereof.

  The experimental protocol display unit 27 displays the protocol used for the experiment on the monitor 1h based on the protocol data stored in the protocol data storage unit 10 during the experiment. Thereby, when an experimenter performs an experiment by directly operating the experimental instrument 19, the experimenter can perform an operation while confirming the protocol. Examples of the experimental instrument 19 to be directly operated by such an experimenter include an electric pipette and a microscope. In addition, when the experimental instrument 19 is a robot and the robot controller interprets the protocol data and automatically performs the experiment, an experimenter who witnesses the experiment is included in the protocol by the protocol display unit 27 during the experiment. You can check which operation is being performed.

  The post-experiment protocol display unit 28, when the protocol is included in the protocol data stored in the protocol data storage unit 10 or the experimental data stored in the experiment data storage unit 11 for the protocol in which the experiment was performed Based on the protocol data, the protocol is displayed on the monitor 1h. Further, the operation record display unit 29 simultaneously records the operation record on the monitor 1h in association with each procedure included in the protocol displayed on the monitor 1h based on the experiment data stored in the experiment data storage unit 11. indicate. In this way, the protocol and experiment data are displayed on the monitor 1h in association with the operation records of the individual procedures, so that it is possible to immediately grasp how the individual procedures included in the experiment were actually performed. it can. The analysis data display unit 30 further displays the analysis data obtained by the external analyzer 23 on the monitor 1h in association with the result sample obtained by the experiment. As a result, the protocol on which the experiment was based, the history of the experiment, and the analysis data obtained as a result of the experiment are shown in association with each other, and these information are linked to each other. It will be shown with objectivity and high reliability. Further, since this recording is automatically recorded by the experimental data recording apparatus 1, there is no extra burden on the experimenter such as requiring detailed entry in the experiment notebook in order to record the experiment.

  FIG. 3 is a diagram illustrating an example of a protocol displayed on the monitor 1 h by the display unit 27 or the protocol display unit 28. As shown here, the protocol is in the form of a chart (chart), and clearly shows each procedure included in the protocol, its execution order and conditions, and instruments used in the experiment. Hereinafter, the protocol in the form of a chart is referred to as a protocol chart. Note that the protocol chart shown in FIG. 3 is a part thereof.

  More specifically, in the protocol chart shown in this example, the sample used for the experiment is accommodated, and the procedure is arranged vertically from top to bottom for each container used for various operations on the sample. The containers used for the experiment are shown side by side, and it is clearly shown that a series of procedures along the vertical axis are sequentially performed on one container.

  The container is represented by a symbol 100a that represents the initial state of the container and a symbol 100b that represents the final state of the container, and the flow of the container or the sample contained in the container is directed from the container symbol 100a to the container symbol 100b. It is indicated by a vertical arrow. The procedure performed on the container or the sample contained in the container is indicated by a symbol 100c indicating the individual procedure. Here, when the procedure is an operation of taking out the contents from the container (for example, “Discard” or the like meaning disposal of the contents), an arrow drawn from the vertical arrow, an operation of adding the contents to the container (for example, , "Add" meaning the addition of a reagent, etc.), an operation that is performed by an arrow that merges with a vertical arrow, or an operation performed by a container alone (for example, "Scrape" meaning scraping of cells, In the case of “Centrifuge” or the like, which means centrifugation, a symbol 100c is arranged on a vertical arrow, so that each procedure is displayed in a visually easy-to-understand manner. Each symbol 100c indicates conditions such as a reagent to be used and a quantity. The order of execution of the procedures in the experiment is determined according to the arrangement position of each symbol, that is, in order of priority from top to bottom, or from left to right in the case of symbols having the same height. Therefore, the execution order of each procedure is also uniquely indicated.

  The protocol data stored in the protocol data storage unit 10 includes a protocol ID uniquely assigned to the protocol as shown in FIG. 3 and procedure data indicating each procedure indicated in the protocol. Here, the procedure data is data corresponding to the individual symbols shown in FIG. The in-experiment protocol display unit 27 interprets the protocol data and displays a protocol chart on the monitor 1h in a manner as shown in FIG. Note that the protocol chart shown in FIG. 3 is an example, and the protocol may be expressed in a different format as a format for expressing the protocol, but at least individual procedures included in the protocol are specified independently. .

  FIG. 4 is a conceptual diagram showing the entire experimental system including the experimental data recording device 1. This figure shows a state in which various devices are communicably connected to a wide area telecommunication line represented by the Internet or the like.

  The experiment data recording apparatus 1 shown in the lower left of the figure is connected to an electric pipette that is an instrument directly operated by an experimenter as an example of the experiment instrument 19, and records the experiment performed by the experimenter. It is intended to be recorded with. The experimental data recording device 1 may be configured to read protocol data created by a protocol creation device 31 that is separately prepared (or may also serve as the experimental data recording device 1 itself).

  The experiment data recording apparatus 1 shown at the lower right in the figure is connected to an automatic device, here a general-purpose robot, as an example of the experimental instrument 19, and performs an experiment based on protocol data by automatic control of the robot, and records it. Is intended to be recorded by the experimental data recording device 1. The experimental data recording apparatus 1 may download protocol data stored in a protocol server 32, which is a server connected through a telecommunication line, record experiments based on the protocol data, and control the robot. . The protocol server 32 may store not only the protocol data created by the experimenter who is the subject of the experiment, but also a large number of protocol data created by a third party. The protocol can be used effectively as an intellectual asset, such as making it easy to make additional tests or conducting new experiments using protocols created by other researchers.

  In addition, the analyzer 23, the experiment ID generation device 24, the experiment data storage device 26, and the like may be connected to the experiment data recording device 1 so as to be communicable with the telecommunication line. These devices have already been described.

  The experimental data collected and recorded by the experimental data recording device 1 through the experimental system shown above is displayed on the monitor 1h of the experimental data recording device 1 on the monitor 1h of the experimental data recording device 1 based on a request from the user. 28, the operation record display unit 29 and the analysis data display unit 30 display them superimposed on the protocol chart. FIG. 5 is a diagram illustrating an example of a state in which experimental data is displayed superimposed on the protocol chart.

  The point that the post-experiment protocol display unit 28 displays the protocol chart on the monitor 1h is almost the same as that by the in-experiment protocol display unit 27 described above. Here, it is assumed that the same protocol chart as that shown in FIG. 3 is shown, and the protocol is indicated by various symbols 100.

  The operation record display unit 29 displays the operation record included in the experimental data in the vicinity of each symbol on the protocol chart. As a result, the operation record and the procedure included in the protocol are displayed in association with each other. In the example illustrated in FIG. 5, for example, the target sample name (“Sample 1”), the target sample ID (“1400010”), and the time when the sample was prepared are directly below the symbol 100a at the upper left. For the symbol 100c, the name of the experimental instrument used ("Pipette 4") and its ID ("450341"), the used chip and its individual number ("Tips 4340" and "2689912"), and the liquid were aspirated and discarded. The measured value of the quantity (“627 μL”) and the time when the procedure was executed are shown. Similarly, the symbol 100c below it indicates the ID of the reagent used (“156710”), and further the symbol 100c below it indicates the individual number of the scraper used (“156710”) along with the time. As described above, the operation record display unit 29 displays the operation record of the experimental instrument in association with each procedure, and the operation record includes the used instrument, consumable, reagent, time, and operation amount (amount and time). ) Etc. are included.

  Further, the symbol 100c below it indicates the transfer of the sample between the containers. As indicated by reference numeral 101 here, an image such as a photograph of the actual sample taken during the experiment, or during the experiment. Physical quantities such as temperature and pH measured and recorded may be shown together as operation records. In this way, it is possible to track in detail how the protocol-based experiments were performed, how individual procedures were performed, and how the sample changed during the process. It becomes possible.

  Further, as indicated by reference numeral 102 at the top of the protocol, various experimental environment data may be indicated together with the experimental ID and protocol ID. As a result, the situation in which the experiment was performed, for example, when and by whom the experiment was performed, can also be confirmed without error.

  Further, the analysis data display unit 30 displays the analysis data as indicated by reference numeral 103 on the monitor 1h together with the protocol chart and the experimental data. The display format of this analysis data is an example, but this is analysis data for sample 1 whose target sample ID is 1400010, the result sample ID as the analysis target is 9400010, and the analysis result is based on some criteria It is shown that the judgment (for example, a reliable experimental result) was OK. Note that “LOG” is displayed at the upper right of the displayed analysis data. In this example, by selecting this part, more detailed information (such as detailed numerical values) of the experimental data can be substituted for the analysis data. It is displayed.

  Further, when a plurality of target samples are tested in a series of experiments based on the same protocol, these may be switched and displayed for each target sample. In the example shown in FIG. 5, a tab 104 is shown on the upper right side of the protocol chart. By selecting a tab corresponding to a target sample ID to be browsed, experimental data and analysis data for each target sample are displayed. It is like that. In displaying the analysis data, the analysis data for a plurality of target samples may be compared and displayed, for example. Further, the display may be switched not only for each target sample but for each result sample.

  FIG. 6 is a flowchart showing an operation of recording the experimental data by the experimental data recording apparatus 1. This flow is shown as an example, and does not necessarily require that all operations shown here are performed.

  First, in step ST1, protocol data is downloaded from the protocol server 32 or the like to the protocol data storage unit 10 and read. The protocol data includes a protocol ID and procedure data.

  In subsequent step ST2, a protocol chart is displayed on the display unit 27 based on the read protocol data.

  In step ST3, the experiment ID issuing unit 13 issues an experiment ID, and the experiment ID recording unit 12 records the experiment ID. The experiment ID is issued, for example, when the experiment ID issuing unit 13 causes the experiment ID generating device 24 to generate an experiment ID.

  In step ST4, the experimental environment data recording unit 14 collects and records necessary information from various devices. Various devices here depend on information necessary as experimental environment data. For example, an ID of an experimenter may be an ID card reader, or an ID of an experimental instrument used in an experiment. It may be a laboratory instrument itself.

  In step ST5, the target sample ID recording unit 15 records the ID of the target sample used for the experiment. The target sample ID may be read by the reader 17, for example.

  In step ST6, the receiving unit 21 receives an operation record of the experimental instrument 19 used for the experiment, and the operation record recording unit 18 records the operation record. This recording is performed for each procedure while the procedure included in the protocol is executed, and each operation record collected is recorded in association with each corresponding procedure included in the protocol.

  In step ST7, the result sample ID recording unit 16 records the ID of the result sample obtained as a result of the experiment. As a result, the sample ID may also be read by the reader 17, for example.

  In step ST8, the analysis data recording unit 22 records the analysis data obtained from the analyzer 23. The analysis data is linked to the result sample ID of the result sample subjected to the analysis.

  In step ST9, the experiment data obtained in this way is subjected to a falsification preventing process by the falsification preventing unit 33, and in a further subsequent step ST10, the experiment data storage unit 25 stores the data in the experiment data storage device 26. As a result, experimental data associated with the protocol ID and subjected to the tampering prevention process is automatically recorded.

  FIG. 7 is a flowchart showing an operation in which the experimental data recording apparatus 1 displays the experimental data superimposed on the protocol chart. This flow is shown as an example, and does not necessarily require that all operations shown here are performed.

  First, in step ST11, experimental data to be displayed is read from the experimental data storage device 26 and stored in the experimental data storage unit 11. This step is not necessary if the experimental data to be displayed has already been stored.

  In subsequent step ST12, the protocol data having the protocol ID associated with the experimental data is downloaded from the protocol server 32 and stored in the protocol data storage unit 10. Since the protocol ID is an ID uniquely assigned to the protocol, the correct protocol used when obtaining the experimental data is downloaded based on the protocol ID. Note that this step is not necessary when protocol data is included in the experimental data.

  In step ST13, a protocol chart is displayed by the protocol display unit 28, and in the subsequent step ST14, the operation record display unit 29 displays the operation record in association with a symbol indicating the procedure in the protocol chart. Further, in step ST15, the analysis data is displayed. The analysis data is displayed by the unit 30. The results displayed in this way are as illustrated in FIG.

  In the above description, the example in which the falsification preventing unit 33 performs the falsification preventing process when the experimental data storage unit 25 stores the experimental data stored in the experimental data storage unit in the experimental data storage device has been described. FIG. 8 shows a functional block diagram of the experimental data recording apparatus 1 according to a modified example in which tampering prevention processing is further strengthened with respect to this example.

  In the experimental data recording apparatus 1 according to the present embodiment, the falsification preventing unit 33 is not between the experimental data storage unit 25 and the communication unit 20 but each recording unit included in the experimental data recording device 1, here, an experiment ID recording unit. 12, the experiment environment data recording unit 14, the target sample ID recording unit 15, the result sample ID recording unit 16, the operation recording recording unit 18, and the analysis data recording unit 22 and the experiment data storage unit 11. Yes. A tampering prevention process is performed each time various information is recorded by each recording unit.

  As a result, the tampering prevention process is also performed on the experiment data stored in the experiment data storage unit 11 before being stored in the experiment data storage device 26. Therefore, the experiment before the tampering prevention process is performed. It is extremely difficult to tamper with data.

  It should be noted that the falsification preventing process by the falsification preventing unit 33 in the present modification does not necessarily have to be performed on the recording of various types of information by all the recording units included in the experimental data recording apparatus 1, and there are circumstances that should prevent falsification. You may make it carry out only about information. For example, the tampering prevention process may be performed at least every time the operation record recording unit 18 records the operation record.

  In the experimental data recording device 1 according to the embodiment described above, the experimental data recording device 1 also performs an operation of displaying the experimental data superimposed on the protocol chart. However, according to the inventor's point of view, the request to view the experimental data together with the protocol is not limited to the experimenter, but can be made by a third party who wants to verify and refer to the experimental results. Is. At this time, if the third party can confirm that the experimental result to be viewed is indeed in accordance with the protocol, and that the result is authentic, objective and accurate, It is thought that there is a great merit such that a lot of time and labor required for verification of the results can be omitted.

  Therefore, the inventor has further invented the experimental data display device 2 that associates the experimental data with the protocol and displays the objective data with high reliability in combination with the experimental data recording device 1. The experimental data display apparatus 2 concerning will be described.

  Since the physical configuration of the experimental data display device 2 is the same as that of the experimental data recording device 1, FIG. 1 is used, and redundant description thereof is omitted. The experimental data display device 2 is the same as the experimental data recording device 1 in that it is realized by executing a program for operating the computer as the experimental data display device 2 on a general computer.

  FIG. 8 is a functional block diagram of the experimental data display device 2. Since the experimental data display device 2 includes the same configuration as the experimental data recording device 1 in terms of its functions, the same functional blocks as those shown in FIG. 2 for the experimental data recording device 1 in FIG. Reference numerals are assigned, and duplicate descriptions are omitted.

  The experiment data reading unit 34 reads the experiment data to be displayed from the experiment data storage device 26 via the communication unit 20 and stores it in the experiment data storage unit 11. The protocol data reading unit 35 reads protocol data having a protocol ID associated with the read experimental data from the protocol server 32 and stores it in the protocol data storage unit 10.

  The operations of the post-experiment protocol display unit 28, the operation record display unit 29, and the analysis data display unit 30 are the same as those of the experimental data recording apparatus 1 described above. The operation of the experimental data display device 2 is the same as that described with reference to FIG.

  In this way, based on the operation data associated with the protocol ID, the protocol data is specified and read, and the operation data and analysis data are displayed superimposed on the protocol chart, thereby associating the experimental data with the protocol and providing objectivity. And it can display with high reliability.

  The configuration of the embodiment described above is shown as a specific example, and the invention disclosed in this specification is not intended to be limited to the configuration of the specific example itself. Those skilled in the art may add various modifications to these disclosed embodiments, and the control shown in the disclosed flowchart may be replaced with another control that has an equivalent function. It should be understood that the technical scope of the invention disclosed herein includes such modifications.

Claims (20)

An experimental data recording device for recording experimental data, which is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology,
A receiving unit for receiving an operation record of the experimental instrument;
An experiment ID recording unit for recording an experiment ID, which is an experiment-specific ID, in association with a protocol ID unique to the protocol;
An operation record recording unit that records each of the received operation records in association with a corresponding procedure among a plurality of procedures included in the protocol;
An experimental data recording apparatus. A target sample ID recording unit that records a target sample ID, which is an ID of a sample subjected to the experiment, in association with the experiment ID;
A result sample ID recording unit that records a result sample ID, which is an ID of a sample obtained as a result of the experiment, in association with the experiment ID;
The experimental data recording apparatus according to claim 1, comprising:   The experiment data recording apparatus according to claim 1, further comprising an experiment environment data recording unit that records experiment environment data in association with the experiment ID.   The experimental data recording apparatus according to claim 1, wherein the experimental instrument includes an instrument that is directly operated by an experimenter.   The experimental data recording apparatus according to claim 4, wherein the experimental instrument includes an electric pipette.   The experiment data recording apparatus according to claim 4 or 5, further comprising an in-experiment protocol display unit for displaying a protocol related to an experiment on a monitor during the experiment.   The experimental data recording apparatus according to claim 1, wherein the experimental instrument includes a robot that performs an experiment based on the protocol.   The experiment data recording apparatus according to claim 1, further comprising an experiment ID issuing unit that issues the experiment ID for each experiment.   The experiment data recording device according to claim 8, wherein the experiment ID issuing unit acquires an experiment ID generated by an external experiment ID generation device.   The experimental data recording apparatus according to claim 1, further comprising a falsification preventing unit that performs a falsification preventing process on the experimental data.   The experimental data recording apparatus according to claim 10, wherein the tampering prevention unit performs a tampering prevention process at least every time the operation recording unit records the operation record.   The experimental data recording device according to claim 1, further comprising an experimental data storage unit that stores the obtained experimental data in an external experimental data storage device.   The experiment according to any one of claims 1 to 12, further comprising an analysis data recording unit that records analysis data, which is analysis result data for a sample obtained as a result of the experiment, in association with a result sample ID of the sample. Data recording device. A post-experiment protocol display that displays the protocol in which the experiment was performed;
In association with each procedure included in the protocol, an operation record display unit that displays an operation record included in the experimental data corresponding to the protocol;
The experimental data recording device according to any one of claims 1 to 13, which has   A computer program for causing a computer to function as the experimental data recording device according to claim 1. Experimental data that is a record of experiments based on protocols in at least one of biochemistry and biological / biotechnology fields,
An experiment ID, which is an experiment-specific ID associated with a protocol ID unique to the protocol;
A record of the operation of the laboratory instrument associated with the corresponding procedure included in the protocol;
Experimental data including An experimental data recording method for recording experimental data, which is a record of an experiment based on a protocol in at least one of biochemistry and biological / biotechnology,
Receives test equipment operation records,
Record the experiment ID, which is an ID unique to the experiment, in association with the protocol ID unique to the protocol,
Each of the received operation records is recorded in association with a corresponding procedure among a plurality of procedures included in the protocol.
Experimental data recording method. Regarding experimental data, which are records of experiments based on protocols in biochemistry and / or biotechnology / biological engineering,
A post-experiment protocol display that displays the protocol in which the experiment was performed;
In association with each procedure included in the protocol, an operation record display unit that displays an operation record of the experimental instrument used in the experiment, included in the experiment data corresponding to the protocol,
An experimental data display device.   The experimental data display device according to claim 18, further comprising an analytical data display unit that displays analytical data corresponding to the experimental data. Regarding experimental data, which are records of experiments based on protocols in biochemistry and / or biotechnology / biological engineering,
Displays the protocol the experiment was conducted on
Corresponding to each of the procedures included in the protocol, the operation record of the experimental instrument used in the experiment included in the experimental data corresponding to the protocol is displayed.
Experimental data display method.

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