JPWO2015056811A1 - Tetrazolinone compounds and uses thereof - Google Patents

Abstract

Formula (1) [In the formula, E represents the following group E16 and the like; Y represents —O—CH 2 and the like; Q represents the following group Q46 and the like; and R8 represents a C1-C6 alkyl group. R3, R30 and R31 are the same or different and each represents a hydrogen atom or the like; A represents a C6-C16 aryl group or the like which may have one or more atoms or groups selected from the group P1; R5 represents a C1-C3 alkyl group or the like; X represents an oxygen atom or a sulfur atom. ] The tetrazolinone compound shown by this has the outstanding control effect with respect to a pest.

Description

  The present invention relates to tetrazolinone compounds and uses thereof.

で示される化合物が知られている（ＥＰ０６９２４８２Ａ参照。）。
また、５員環ヘテロ環で置換されたテトラゾリノン環を有する化合物として、
下記式（Ｂ１）および（Ｂ２）

で示される化合物が知られている（ＥＰ０６９５７４８Ａ参照。）。Conventionally, various drugs have been developed and put into practical use for controlling pests, but these drugs are not always sufficient.
On the other hand, as a compound having a tetrazolinone ring substituted with a 6-membered heterocycle,
The following formulas (A1) and (A2)

Is known (see EP 0694822A).
In addition, as a compound having a tetrazolinone ring substituted with a 5-membered heterocycle,
The following formulas (B1) and (B2)

Is known (see EP0695748A).

The present invention provides a compound having an excellent control effect against pests.

〔式中、
Ｒ^５は、１以上のハロゲン原子を有していてもよいＣ１−Ｃ３アルキル基を表し；
Ｅは２価の５員ヘテロアリール基または２価の６員ヘテロアリール基を表し；
Ｙは、＊−（ＣＨ_２）_ｎ−Ｇ−＆、＊−Ｇ−（ＣＨ_２）_ｎ−＆、＊−Ｇ−（ＣＨ_２）_ｎ−Ｇ−＆、＊−Ｇ−ＣＨ_２ＣＨ_２−Ｇ−ＣＨ_２ＣＨ_２−Ｇ−＆、＊−ＣＨ_２−Ｇ−ＣＨ_２ＣＨ_２−Ｇ−＆、＊−Ｇ−ＣＨ_２ＣＨ_２−Ｇ−ＣＨ_２−＆、＊−ＣＨ＝ＣＨ−＆、＊−ＣＨ＝ＣＨ−Ｇ−＆、＊−Ｇ−ＣＨ＝ＣＨ−＆、＊−ＣＨ＝ＣＨ＝ＣＨ_２−Ｇ−＆、＊−Ｇ−ＣＨ_２−ＣＨ＝ＣＨ−＆、＊−Ｇ−ＣＨ＝ＣＨ＝ＣＨ_２−＆、＊−ＣＨ_２−ＣＨ＝ＣＨ−Ｇ−＆、＊−ＣＨ＝ＣＨ−Ｇ−ＣＨ_２−＆、＊−ＣＨ_２−Ｇ−ＣＨ＝ＣＨ−＆、＊−ＣＨ＝ＣＨ−ＣＨ_２−Ｇ−ＣＨ_２−＆、＊−ＣＨ_２−Ｇ−ＣＨ_２−ＣＨ＝ＣＨ−＆、＊−ＣＨ＝ＣＨ−Ｇ−ＣＨ_２ＣＨ_２−＆、＊−ＣＨ_２ＣＨ_２−Ｇ−ＣＨ＝ＣＨ−＆、＊−Ｇ−ＣＨ＝ＣＨ−ＣＨ_２ＣＨ_２−＆、＊−ＣＨ_２ＣＨ_２−ＣＨ＝ＣＨ−Ｇ−＆、＊−ＣＨ＝ＣＨ−Ｇ−ＣＨ＝ＣＨ−＆、＊−Ｃ≡Ｃ−＆、＊−Ｃ≡Ｃ−ＣＨ_２−Ｇ−＆、＊−Ｇ−ＣＨ_２−Ｃ≡Ｃ−＆、＊−Ｃ≡Ｃ−ＣＨ_２−Ｇ−ＣＨ_２−＆または＊−ＣＨ_２−Ｇ−ＣＨ_２−Ｃ≡Ｃ−＆を表し
（但し、Ｙの有する全ての水素原子は（Ｇが有する水素原子を含む）、ハロゲン原子およびＣ１−Ｃ３アルキル基からなる群より選ばれる１以上の原子または基で置換されていてもよく、２以上の原子または基で置換される場合、該原子および基は同一または相異なっていてもよく；Ｇは酸素原子、硫黄原子、またはＮＲ^Ｂを表し；Ｒ^Ｂは、水素原子またはＣ１−Ｃ３アルキル基を表し、ｎは１〜１０の整数を表す。また、Ｙにおいて、＊はＱとの結合位置を表し、＆はＥとの結合位置を表す。）；
Ｑは、２価のＣ６−Ｃ１０アリール基（但し、該２価のＣ６−Ｃ１０アリール基は、群Ｐ^２から選ばれる１以上の原子または基を有していてもよい。）または２価の５−１０員ヘテロ環基（但し、該２価の５−１０員ヘテロ環基は、群Ｐ^２から選ばれる１以上の原子もしくは基を有していてもよく、環構成原子として窒素原子、酸素原子および硫黄原子からなる群より選ばれる１以上の原子を含有し、２以上の原子を含有する場合、該原子は同一もしくは相異なっていてもよい。）を表し；
Ｘは、酸素原子または硫黄原子を表し；
Ａは、Ｃ６−Ｃ１０アリール基、アダマンチル基、Ｃ６−Ｃ１０アリールオキシ基、Ｃ６−Ｃ１０アリールチオ基、Ｃ６−Ｃ１０アリールアミノ基、Ｃ３−Ｃ１０シクロアルキル基、５−１０員ヘテロ環基（但し、該５−１０員ヘテロ環基は、環構成原子として窒素原子、酸素原子および硫黄原子からなる群より選ばれる１以上の原子を含有し、２以上の原子を含有する場合、該原子は同一もしくは相異なっていてもよい。）、５−１０員ヘテロアリールオキシ基（但し、該５−１０員ヘテロアリールオキシ基は、環構成原子として窒素原子、酸素原子および硫黄原子からなる群より選ばれる１以上の原子を含有し、２以上の原子を含有する場合、該原子は同一もしくは相異なっていてもよい。）、５−１０員ヘテロアリールチオ基（但し、該５−１０員ヘテロアリールチオ基は、環構成原子として窒素原子、酸素原子および硫黄原子からなる群より選ばれる１以上の原子を含有し、２以上の原子を含有する場合、該原子は同一もしくは相異なっていてもよい。）、５−１０員ヘテロアリールアミノ基（但し、該５−１０員ヘテロアリールアミノ基は、環構成原子として窒素原子、酸素原子および硫黄原子からなる群より選ばれる１以上の原子を含有し、２以上の原子を含有する場合、該原子は同一もしくは相異なっていてもよい。）、Ｃ６−Ｃ１０アリールスルホニル基、Ｃ６−Ｃ１０アリールスルフィニル基、または群Ｐ^３から選ばれる１もしくは２の基を有していてもよい−ＣＨ＝ＮＨ（但し、該−ＣＨ＝ＮＨが群Ｐ^３から選ばれる基を２つ有する場合、該基は同一または相異なっていてもよい。）を表す（但し、該Ｃ６−Ｃ１０アリール基、アダマンチル基、Ｃ６−Ｃ１０アリールオキシ基、Ｃ６−Ｃ１０アリールチオ基、Ｃ６−Ｃ１０アリールアミノ基、Ｃ３−Ｃ１０シクロアルキル基、５−１０員ヘテロ環基、５−１０員ヘテロアリールオキシ基、５−１０員ヘテロアリールチオ基、５−１０員ヘテロアリールアミノ基、Ｃ６−Ｃ１０アリールスルホニル基およびＣ６−Ｃ１０アリールスルフィニル基は、群Ｐ^１から選ばれる１以上の原子もしくは基を有していてもよく、２以上の原子もしくは基を有する場合、該原子もしくは基は同一または相異なっていてもよい。）。
群Ｐ^１：ハロゲン原子、Ｃ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ２−Ｃ６アルケニル基、Ｃ２−Ｃ６ハロアルケニル基、Ｃ２−Ｃ６アルキニル基、Ｃ２−Ｃ６ハロアルキニル基、Ｃ３−Ｃ６シクロアルキル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ６アルコキシ基、Ｃ１−Ｃ６ハロアルコキシ基、Ｃ１−Ｃ６アルキルチオ基、Ｃ１−Ｃ６ハロアルキルチオ基、Ｃ３−Ｃ６シクロアルキルオキシ基、Ｃ３−Ｃ６ハロシクロアルキルオキシ基、Ｃ３−Ｃ６シクロアルキルチオ基、Ｃ３−Ｃ６アルケニルオキシ基、Ｃ３−Ｃ６アルキニルオキシ基、Ｃ３−Ｃ６ハロアルケニルオキシ基、Ｃ３−Ｃ６ハロアルキニルオキシ基、Ｃ３−Ｃ６アルケニルチオ基、Ｃ３−Ｃ６アルキニルチオ基、Ｃ３−Ｃ６ハロアルケニルチオ基、Ｃ３−Ｃ６ハロアルキニルチオ基、Ｃ２−Ｃ６アルキルカルボニル基、Ｃ２−Ｃ６ハロアルキルカルボニル基、Ｃ２−Ｃ６アルキルカルボニルオキシ基、Ｃ２−Ｃ６アルキルカルボニルチオ基、カルボキシ基、ホルミル基、Ｃ２−Ｃ６アルコキシカルボニル基、ニトロ基、シアノ基、ヒドロキシ基、Ｃ１−Ｃ６アルキルスルホニル基、Ｃ１−Ｃ６ハロアルキルスルホニル基、、Ｃ１−Ｃ６アルキルスルフィニル基、Ｃ１−Ｃ６ハロアルキルスルフィニル基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノ基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノスルホニル基およびＣ１−Ｃ６アルキル基を有していてもよいアミノカルボニル基からなる群。
群Ｐ^２：ハロゲン原子、シアノ基、Ｃ３−Ｃ６シクロアルキル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ４アルコキシ基、Ｃ１−Ｃ４ハロアルコキシ基、Ｃ１−Ｃ４アルキルチオ基およびＣ１−Ｃ４ハロアルキルチオ基からなる群。
群Ｐ^３：Ｃ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ３−Ｃ６シクロアルキル基、およびＣ３−Ｃ６ハロシクロアルキル基からなる群。〕
で示されるテトラゾリノン化合物。As a result of studies to find a compound having an excellent control effect against pests, the present inventors have found that the tetrazolinone compound represented by the following formula (1) has an excellent control effect against pests. The present invention has been completed.
That is, the present invention is as follows [1] to [6].
[1] Formula (1)

[Where,
R ⁵ represents a C1-C3 alkyl group optionally having one or more halogen atoms;
E represents a divalent 5-membered heteroaryl group or a divalent 6-membered heteroaryl group;
Y _{is, * - (CH 2) n} -G - &, * - G- (CH 2) n - &, * - G- (CH 2) n -G - &, * - G-CH 2 CH 2 - _{G-CH 2 CH 2 -G -} &, * - CH 2 -G-CH 2 CH 2 -G - &, * - G-CH 2 CH 2 -G-CH 2 - &, * - CH = CH- & , * - CH = CH-G - &, * - G-CH = CH - &, * - CH = CH = CH 2 -G - &, * - G-CH 2 -CH = CH - &, * - G _{-CH = CH = CH 2 - &} , * - CH 2 -CH = CH-G - &, * - CH = CH-G-CH 2 - &, * - CH 2 -G-CH = CH - &, * _{-CH = CH-CH 2 -G-} CH 2 - &, * - CH 2 -G-CH 2 -CH = CH - &, * - CH = CH-G-CH 2 CH 2 - &, * - CH 2 CH ₂ -G-CH = CH- & _{* -G-CH = CH-CH} 2 CH 2 - &, * - CH 2 CH 2 -CH = CH-G - &, * - CH = CH-G-CH = CH - &, * - C≡C- _{&, * - C≡C-CH 2} -G - &, * - G-CH 2 -C≡C - &, * - C≡C-CH 2 -G-CH 2 - & or * _-CH 2 -G —CH ₂ —C≡C— & (wherein all the hydrogen atoms of Y (including the hydrogen atom of G) are one or more atoms selected from the group consisting of halogen atoms and C1-C3 alkyl groups Or when substituted with two or more atoms or groups, the atoms and groups may be the same or different; G represents an oxygen atom, a sulfur atom, or NR ^B ; R ^B represents a hydrogen atom or a C1-C3 alkyl group, n represents an integer from 1 to 10. Furthermore, our in Y Te, * represents the bonding position with Q, & represents a bonding position to E).;
Q is a divalent C6-C10 aryl group (provided that the bivalent C6-C10 aryl group may have one or more atoms or groups selected from the group ^{P 2.)} Or divalent 5-10-membered heterocyclic group (provided that the divalent 5-10-membered heterocyclic group may have one or more atoms or groups selected from group P ² , and a nitrogen atom as a ring-constituting atom, 1 or more atoms selected from the group consisting of an oxygen atom and a sulfur atom are contained, and when 2 or more atoms are contained, these atoms may be the same or different.
X represents an oxygen atom or a sulfur atom;
A represents a C6-C10 aryl group, an adamantyl group, a C6-C10 aryloxy group, a C6-C10 arylthio group, a C6-C10 arylamino group, a C3-C10 cycloalkyl group, a 5-10-membered heterocyclic group (provided that the The 5- to 10-membered heterocyclic group contains one or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom as ring-constituting atoms. 5-10 membered heteroaryloxy group (provided that the 5-10 membered heteroaryloxy group is one or more selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as a ring-constituting atom) In the case where two or more atoms are contained, the atoms may be the same or different, and a 5- to 10-membered heteroarylthio group (provided that The 5- to 10-membered heteroarylthio group contains one or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as ring constituent atoms, and when containing two or more atoms, the atoms are the same or 5-10 membered heteroarylamino group (provided that the 5-10 membered heteroarylamino group is selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as a ring atom) It contains more atoms, when containing 2 or more atoms, the atoms may be different from the same or different.), selected from C6-C10 arylsulfonyl group, C6-C10 arylsulfinyl group or group P ^3, good -CH = NH optionally having 1 or 2 groups that are (when the -CH = NH has two groups selected from the group ^{P 3,} the base may be the same or different Which may be different from each other. However, the C6-C10 aryl group, adamantyl group, C6-C10 aryloxy group, C6-C10 arylthio group, C6-C10 arylamino group, C3-C10 cycloalkyl group, 5 A -10 membered heterocyclic group, a 5-10 membered heteroaryloxy group, a 5-10 membered heteroarylthio group, a 5-10 membered heteroarylamino group, a C6-C10 arylsulfonyl group and a C6-C10 arylsulfinyl group are It may have one or more atoms or groups selected from P ¹ , and when it has two or more atoms or groups, these atoms or groups may be the same or different.)
Group P ¹ : halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkenyl group, C2-C6 haloalkenyl group, C2-C6 alkynyl group, C2-C6 haloalkynyl group, C3-C6 cycloalkyl Group, C3-C6 halocycloalkyl group, C1-C6 alkoxy group, C1-C6 haloalkoxy group, C1-C6 alkylthio group, C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyl group Oxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3-C6 haloalkenyloxy group, C3-C6 haloalkynyloxy group, C3-C6 alkenylthio group, C3-C6 Alkynylthio group, C3-C6 haloalkenylthio group, C -C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group, C2-C6 alkylcarbonylthio group, carboxy group, formyl group, C2-C6 alkoxycarbonyl group, It may have a nitro group, a cyano group, a hydroxy group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, or a C1-C6 alkyl group. A group consisting of an amino group, an aminosulfonyl group optionally having a C1-C6 alkyl group, and an aminocarbonyl group optionally having a C1-C6 alkyl group.
Group P ² : halogen atom, cyano group, C3-C6 cycloalkyl group, C3-C6 halocycloalkyl group, C1-C4 alkoxy group, C1-C4 haloalkoxy group, C1-C4 alkylthio group and C1-C4 haloalkylthio group A group consisting of
Group P ³ : A group consisting of a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C6 cycloalkyl group, and a C3-C6 halocycloalkyl group. ]
A tetrazolinone compound represented by:

〔式中、＃はテトラゾリノン環との結合位置を表し、＄はＹとの結合位置を表す。また、Ｚ^１は、窒素原子またはＣＲ^１を表し；Ｚ^２は、窒素原子またはＣＲ^２を表し；Ｚ^３は、窒素原子またはＣＲ^３を表し；Ｚ^４は、窒素原子またはＣＲ^４を表し；
Ｙ^１は、酸素原子、硫黄原子またはＮＲ^８を表し；Ｙ^２は、酸素原子、硫黄原子またはＮＲ^６を表し； Ｙ^３は、酸素原子、硫黄原子またはＮＲ^７を表し；
Ｒ^１は、水素原子、Ｃ１−Ｃ６アルキル基、Ｃ３−Ｃ６シクロアルキル基、ハロゲン原子、Ｃ１−Ｃ６ハロアルキル基、Ｃ２−Ｃ６アルケニル基、Ｃ１−Ｃ６アルコキシ基、Ｃ１−Ｃ６アルキルチオ基、Ｃ２−Ｃ６アルキニル基、ニトロ基、シアノ基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノカルボニル基、
Ｃ２−Ｃ６ハロアルケニル基、Ｃ２−Ｃ６ハロアルキニル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ６ハロアルコキシ基、Ｃ１−Ｃ６ハロアルキルチオ基、Ｃ３−Ｃ６シクロアルキルオキシ基、Ｃ３−Ｃ６ハロシクロアルキルオキシ基、Ｃ３−Ｃ６シクロアルキルチオ基、Ｃ３−Ｃ６アルケニルオキシ基、Ｃ３−Ｃ６アルキニルオキシ基、Ｃ３−Ｃ６ハロアルケニルオキシ基、Ｃ３−Ｃ６ハロアルキニルオキシ基、Ｃ３−Ｃ６アルケニルチオ基、Ｃ３−Ｃ６アルキニルチオ基、Ｃ３−Ｃ６ハロアルケニルチオ基、Ｃ３−Ｃ６ハロアルキニルチオ基、Ｃ２−Ｃ６アルキルカルボニル基、Ｃ２−Ｃ６ハロアルキルカルボニル基、Ｃ２−Ｃ６アルキルカルボニルオキシ基、Ｃ２−Ｃ６アルキルカルボニルチオ基、Ｃ２−Ｃ６アルコキシカルボニル基、ヒドロキシ基、チオール基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノ基、ペンタフルオロスルファニル基、Ｃ３−Ｃ９トリアルキルシリル基、Ｃ５−Ｃ１４トリアルキルシリルエチニル基、Ｃ１−Ｃ４アルキルスルホニル基、Ｃ１−Ｃ４ハロアルキルスルホニル基、Ｃ１−Ｃ４アルキルスルフィニル基、Ｃ１−Ｃ４ハロアルキルスルフィニル基、Ｃ２−Ｃ５アルコキシアルキル基またはＣ２−Ｃ５アルキルチオアルキル基を表し；
Ｒ^２，Ｒ^３およびＲ^４はそれぞれ独立して、水素原子、ハロゲン原子、Ｃ１−Ｃ３アルキル基、Ｃ１−Ｃ３ハロアルキル基、Ｃ２−Ｃ３アルケニル基、Ｃ２−Ｃ３ハロアルケニル基またはＣ１−Ｃ３アルコキシ基を表し；
Ｒ^６およびＲ^７はそれぞれ独立して、水素原子、Ｃ１−Ｃ３アルキル基、Ｃ１−Ｃ３ハロアルキル基、Ｃ２−Ｃ３アルケニル基、Ｃ２−Ｃ３ハロアルケニル基またはＣ１−Ｃ３アルコキシ基を表し；
Ｒ^８は、水素原子、Ｃ１−Ｃ６アルキル基、Ｃ３−Ｃ６シクロアルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ２−Ｃ６アルケニル基、Ｃ１−Ｃ６アルコキシ基、Ｃ１−Ｃ６アルキルチオ基、Ｃ２−Ｃ６アルキニル基、ニトロ基、シアノ基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノカルボニル基、Ｃ２−Ｃ６ハロアルケニル基、Ｃ２−Ｃ６ハロアルキニル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ６ハロアルコキシ基、Ｃ１−Ｃ６ハロアルキルチオ基、Ｃ３−Ｃ６シクロアルキルオキシ基、Ｃ３−Ｃ６ハロシクロアルキルオキシ基、Ｃ３−Ｃ６シクロアルキルチオ基、Ｃ３−Ｃ６アルケニルオキシ基、Ｃ３−Ｃ６アルキニルオキシ基、Ｃ３−Ｃ６ハロアルケニルオキシ基、Ｃ３−Ｃ６ハロアルキニルオキシ基、Ｃ３−Ｃ６アルケニルチオ基、Ｃ３−Ｃ６アルキニルチオ基、Ｃ３−Ｃ６ハロアルケニルチオ基、Ｃ３−Ｃ６ハロアルキニルチオ基、Ｃ２−Ｃ６アルキルカルボニル基、Ｃ２−Ｃ６ハロアルキルカルボニル基、Ｃ２−Ｃ６アルキルカルボニルオキシ基、Ｃ２−Ｃ６アルキルカルボニルチオ基、Ｃ２−Ｃ６アルコキシカルボニル基、ヒドロキシ基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノ基、ペンタフルオロスルファニル基、Ｃ３−Ｃ９トリアルキルシリル基、Ｃ５−Ｃ１４トリアルキルシリルエチニル基、Ｃ１−Ｃ４アルキルスルホニル基、Ｃ１−Ｃ４ハロアルキルスルホニル基、Ｃ１−Ｃ４アルキルスルフィニル基、Ｃ１−Ｃ４ハロアルキルスルフィニル基、Ｃ２−Ｃ５アルコキシアルキル基またはＣ２−Ｃ５アルキルチオアルキル基を表す。〕[2] E is any one of groups selected from the group P ^4, tetrazolinone compound according to [1].
Group P ⁴ : Group consisting of E1 to E7.

[In the formula, # represents a bonding position with a tetrazolinone ring, and $ represents a bonding position with Y. Z ¹ represents a nitrogen atom or CR ¹ ; Z ² represents a nitrogen atom or CR ² ; Z ³ represents a nitrogen atom or CR ³ ; Z ⁴ represents a nitrogen atom or CR ⁴ ;
Y ¹ represents an oxygen atom, a sulfur atom or NR ⁸ ; Y ² represents an oxygen atom, a sulfur atom or NR ⁶ ; Y ³ represents an oxygen atom, a sulfur atom or NR ⁷ ;
R ¹ is a hydrogen atom, C1-C6 alkyl group, C3-C6 cycloalkyl group, halogen atom, C1-C6 haloalkyl group, C2-C6 alkenyl group, C1-C6 alkoxy group, C1-C6 alkylthio group, C2-C6. An aminocarbonyl group optionally having an alkynyl group, a nitro group, a cyano group, a C1-C6 alkyl group,
C2-C6 haloalkenyl group, C2-C6 haloalkynyl group, C3-C6 halocycloalkyl group, C1-C6 haloalkoxy group, C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyl group Oxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3-C6 haloalkenyloxy group, C3-C6 haloalkynyloxy group, C3-C6 alkenylthio group, C3-C6 Alkynylthio group, C3-C6 haloalkenylthio group, C3-C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group, C2-C6 alkylcarbonylthio group, C2-C6 alkoxycarbo Group, hydroxy group, thiol group, amino group optionally having C1-C6 alkyl group, pentafluorosulfanyl group, C3-C9 trialkylsilyl group, C5-C14 trialkylsilylethynyl group, C1-C4 alkyl group Represents a sulfonyl group, a C1-C4 haloalkylsulfonyl group, a C1-C4 alkylsulfinyl group, a C1-C4 haloalkylsulfinyl group, a C2-C5 alkoxyalkyl group or a C2-C5 alkylthioalkyl group;
R ² , R ³ and R ⁴ are each independently a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 haloalkyl group, a C2-C3 alkenyl group, a C2-C3 haloalkenyl group or a C1-C3 alkoxy group. Represents;
R ⁶ and R ⁷ each independently represents a hydrogen atom, a C1-C3 alkyl group, a C1-C3 haloalkyl group, a C2-C3 alkenyl group, a C2-C3 haloalkenyl group or a C1-C3 alkoxy group;
R ⁸ is a hydrogen atom, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C1-C6 alkylthio group, a C2-C6 alkynyl group, Nitro group, cyano group, aminocarbonyl group optionally having C1-C6 alkyl group, C2-C6 haloalkenyl group, C2-C6 haloalkynyl group, C3-C6 halocycloalkyl group, C1-C6 haloalkoxy group , C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyloxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3-C6 halo Alkenyloxy group, C3-C6 haloalkynyloxy group, C3-C6 alkeni Ruthio group, C3-C6 alkynylthio group, C3-C6 haloalkenylthio group, C3-C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group, C2- C6 alkylcarbonylthio group, C2-C6 alkoxycarbonyl group, hydroxy group, amino group optionally having C1-C6 alkyl group, pentafluorosulfanyl group, C3-C9 trialkylsilyl group, C5-C14 trialkylsilyl group An ethynyl group, a C1-C4 alkylsulfonyl group, a C1-C4 haloalkylsulfonyl group, a C1-C4 alkylsulfinyl group, a C1-C4 haloalkylsulfinyl group, a C2-C5 alkoxyalkyl group or a C2-C5 alkylthioalkyl group is represented. ]

[3] The tetrazolinone compound according to [1] or [2], wherein Y is —O—CH ₂ —.
[4] A pest control agent comprising the tetrazolinone compound according to any one of [1] to [3].
[5] A method for controlling pests, wherein an effective amount of the tetrazolinone compound according to any one of [1] to [3] is applied to a plant or soil.
[6] Use of the tetrazolinone compound according to any one of [1] to [3] for controlling pests.
According to the present invention, pests can be controlled.

〔Ｒ^５、Ｘ、Ｅ、Ｙ、Ｑ及びＡは前記と同じ意味を表す。〕
で示されるテトラゾリノン化合物（以下、本発明化合物と記載する。）である。The compounds of the present invention have the formula (1)

[R ⁵ , X, E, Y, Q, and A represent the same meaning as described above. ]
Is a tetrazolinone compound (hereinafter referred to as the present compound).

The substituents in this specification are described below.
In the present invention, the “member” represents the number of atoms constituting a ring such as aryl, heterocycle, heteroaryl and the like. For example, naphthalene is represented as 10 members, and the following benzofuran is represented as 9 members.

Examples of the halogen atom include a fluorine atom, a chlorine atom, a bromine atom and an iodine atom.
The C1-C3 alkyl group includes a methyl group, an ethyl group, a propyl group, and an isopropyl group.
The C1-C3 alkyl group optionally having one or more halogen atoms represents a C1-C3 alkyl group in which one or more hydrogen atoms of the C1-C3 alkyl group may be substituted with a halogen atom. , Methyl group, ethyl group, propyl group, isopropyl group, fluoromethyl group, chloromethyl group, difluoromethyl group, trifluoromethyl group, 2,2,2-trifluoroethyl group, pentafluoroethyl group, 2,2- Examples include difluoroethyl group, 2-fluoropropyl group, 3-fluoropropyl group, 2,2-difluoropropyl group, 3,3,3-trifluoropropyl group, and 3- (fluoromethyl) -2-fluoroethyl group. .

〔式中、Ｒ^１、Ｒ^２、Ｒ^３、Ｒ^４、Ｒ^５、Ｒ^６、Ｒ^７及びＲ^８は前記と同じ意味を表す。〕The 5-membered heteroaryl group represents a group containing one or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as a ring atom, and when containing two or more atoms, the atoms are the same Or they may be different.
Examples of the divalent 5-membered heteroaryl group include thiophene-di-yl group, furan-di-yl group, pyrrole-di-yl group, pyrazol-di-yl group, imidazole-di-yl group, and thiazole- Di-yl, isothiazol-di-yl, oxazol-di-yl, isoxazol-di-yl, triazol-di-yl, oxadiazole-di-yl and thiadiazol-di-yl can give. .
For example, the following groups E11 to E46 (in the formula, # represents a bonding position with a tetrazolinone ring, and $ represents a bonding position with Y).

[Wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ and R ⁸ represent the same meaning as described above. ]

〔式中、Ｒ^１、Ｒ^２、Ｒ^３、Ｒ^４、Ｒ^５、Ｒ^６、Ｒ^７及びＲ^８は前記と同じ意味を表す。〕
２価のＣ６−Ｃ１０アリール基としては、例えば、ベンゼン−１，２−ジ−イル基、ベンゼン−１，３−ジ−イル基、ベンゼン−１，４−ジ−イル基、ナフタレン−１，２−ジ−イル基、ナフチル−１，６−ジ−イル基およびナフチル−１，８−ジ−イル基が挙げられる。The 6-membered heteroaryl group represents a group containing one or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as a ring-constituting atom, and when containing two or more atoms, the atoms are the same Or they may be different.
Examples of the divalent 6-membered heteroaryl group include pyridine-di-yl group, pyrimidine-di-yl group, pyrazin-di-yl group, pyridazine-di-yl group, triazine-di-yl group and tetrazine- And di-yl group.
For example, the following groups E50 to E65 (in the formula, # represents a bonding position with a tetrazolinone ring and $ represents a bonding position with Y). ;

[Wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ and R ⁸ represent the same meaning as described above. ]
Examples of the divalent C6-C10 aryl group include benzene-1,2-di-yl group, benzene-1,3-di-yl group, benzene-1,4-di-yl group, naphthalene-1, Examples include 2-di-yl group, naphthyl-1,6-di-yl group, and naphthyl-1,8-di-yl group.

The 5- to 10-membered heterocyclic group represents a group containing one or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as a ring constituent atom, and when containing two or more atoms, May be the same or different.
Examples of the divalent 5-10 membered heterocyclic group include a pyridine-di-yl group, a pyrimidine-di-yl group, a pyrazine-di-yl group, a pyridazine-di-yl group, a thiophene-di-yl group, Furan-di-yl group, pyrrole-di-yl group, pyrazole-di-yl group, imidazole-di-yl group, thiazol-di-yl group, isothiazol-di-yl group, oxazol-di-yl group, Isoxazol-di-yl group, triazol-di-yl group, tetrazole-di-yl group, oxadiazole-di-yl group, thiadiazol-di-yl group, benzofuran-di-yl group, benzothiophene-di-yl Group, indole-di-yl group, benzimidazol-di-yl group, indazole-di-yl group, benzothiazol-di-yl group, benzoxazol-di-yl group Benzoisothiazol-di-yl group, benzoisoxazol-di-yl group, pyrazolopyrrole-di-yl group, pyrazolopyrazol-di-yl group, pyrazoloimidazole-di-yl group, imidazopyrimidine-di -Yl group, imidazopyrazin-di-yl group, triazopyridin-di-yl group, triazopyrimidin-di-yl group, triazoquinolin-di-yl group, 2,3-dihydrobenzofuran-di-yl group 2,3-dihydrobenzothiophene-di-yl group, 1,3-benzodioxol-di-yl group, quinolin-di-yl group, isoquinolin-di-yl group, cinnoline-di-yl group, phthalazine -Di-yl group, quinazoline-di-yl group, quinoxaline-di-yl group, naphthyridin-di-yl group, chroman-di-yl group, isochroman-di-yl group Thienopyridine - di - yl group, Chienopirazoru - di - yl group and Chienokinorin - di - yl group, and preferably a pyrazole - di - yl group, and a thiazole - di - yl group.
For example, the following groups Q1 to Q366 (in the formula, # represents a bonding position with Y and $ represents a bonding position with A).

〔式中、Ｒ^３０、Ｒ^３１、Ｒ^３２、Ｒ^３３、Ｒ^３４、Ｒ^３５、Ｒ^３６、Ｒ^３７、Ｒ^３８、Ｒ^４０、Ｒ^４１、Ｒ^４２およびＲ^４３はそれぞれ独立して、水素原子、ハロゲン原子、シアノ基、Ｃ３−Ｃ６シクロアルキル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ４アルコキシ基、Ｃ１−Ｃ４ハロアルコキシ基、Ｃ１−Ｃ４アルキルチオ基またはＣ１−Ｃ４ハロアルキルチオ基を表し；
Ｒ^３９は、水素原子、シアノ基、Ｃ３−Ｃ６シクロアルキル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ４アルコキシ基、Ｃ１−Ｃ４ハロアルコキシ基、Ｃ１−Ｃ４アルキルチオ基またはＣ１−Ｃ４ハロアルキルチオ基を表す。〕

[Wherein R ³⁰ , R ³¹ , R ³² , R ³³ , R ³⁴ , R ³⁵ , R ³⁶ , R ³⁷ , R ³⁸ , R ⁴⁰ , R ⁴¹ , R ⁴² and R ⁴³ are each independently a hydrogen atom Represents a halogen atom, a cyano group, a C3-C6 cycloalkyl group, a C3-C6 halocycloalkyl group, a C1-C4 alkoxy group, a C1-C4 haloalkoxy group, a C1-C4 alkylthio group or a C1-C4 haloalkylthio group;
R ³⁹ is a hydrogen atom, a cyano group, a C3-C6 cycloalkyl group, a C3-C6 halocycloalkyl group, a C1-C4 alkoxy group, a C1-C4 haloalkoxy group, a C1-C4 alkylthio group or a C1-C4 haloalkylthio group. Represents. ]

The C6-C10 aryl group specifically represents a phenyl group, a 1-naphthyl group, and a 2-naphthyl group.
Specifically, the C6-C10 aryloxy group represents a phenoxy group, a 1-naphthyloxy group, and a 2-naphthyloxy group.
A C6-C10 arylthio group specifically represents a phenylthio group, a 1-naphthylthio group, and a 2-naphthylthio group.
The C6-C10 arylamino group specifically represents a phenylamino group, a (1-naphthyl) amino group, and a (2-naphthyl) amino group.
The C3-C10 cycloalkyl group specifically represents a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cycloheptyl group, a cyclooctyl group, a cyclononyl group, and a cyclodecyl group.
The C6-C10 arylsulfonyl group specifically represents a phenylsulfonyl group, a 1-naphthylsulfonyl group, and a 2-naphthylsulfonyl group.
The C6-C10 arylsulfinyl group specifically represents a phenylsulfinyl group, a 1-naphthylfinyl group, and a 2-naphthylsulfinyl group.

Examples of the 5- to 10-membered heterocyclic group include pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, thienyl group, furyl group, pyrrolyl group, pyrazolyl group, imidazolyl group, thiazolyl group, isothiazolyl group, oxazolyl group, isoxazolyl group , Triazolyl group, tetrazolyl group, oxazoazolyl group, thiadiazolyl group, benzofuryl group, benzothienyl group, indolyl group, benzoimidazolyl group, indazolyl group, benzothiazolyl group, benzoxazolyl group, benzoisothiazolyl group, benzoisoxazolyl group , Pyrazolopyrrolyl group, pyrazolopyrazolyl group, pyrazoloimidazolyl group, imidazopyrimidinyl group, imidazopyrazinyl group, triazolopyridyl group, triazolopyrimidinyl group, triazoloquinolyl group, 2,3-dihi Lobenzofuryl group, 2,3-dihydrobenzothienyl group, 1,3-benzodioxolyl group, quinolyl group, isoquinolyl group, cinnolinyl group, phthalazinyl group, quinazolinyl group, quinoxalinyl group, naphthyridinyl group, chromanyl group, isochromanyl group, thienopyridyl group Group, thienopyrazolyl group and thienoquinolyl group, preferably pyridyl group.
For example, the following groups A1 to A133 (wherein # represents a binding site with Q) can be mentioned.

［式中、Ｒ^５０、Ｒ^５１、Ｒ^５２、Ｒ^５３、Ｒ^５４、Ｒ^５５、Ｒ^５６、Ｒ^５７、Ｒ^５８、Ｒ^６０、Ｒ^６１、Ｒ^６２およびＲ^６３はそれぞれ独立して、水素原子、ハロゲン原子、Ｃ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ２−Ｃ６アルケニル基、Ｃ２−Ｃ６ハロアルケニル基、Ｃ２−Ｃ６アルキニル基、Ｃ２−Ｃ６ハロアルキニル基、Ｃ３−Ｃ６シクロアルキル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ６アルコキシ基、Ｃ１−Ｃ６ハロアルコキシ基、Ｃ１−Ｃ６アルキルチオ基、Ｃ１−Ｃ６ハロアルキルチオ基、Ｃ３−Ｃ６シクロアルキルオキシ基、Ｃ３−Ｃ６ハロシクロアルキルオキシ基、Ｃ３−Ｃ６シクロアルキルチオ基、Ｃ３−Ｃ６アルケニルオキシ基、Ｃ３−Ｃ６アルキニルオキシ基、Ｃ３−Ｃ６ハロアルケニルオキシ基、Ｃ３−Ｃ６ハロアルキニルオキシ基、Ｃ３−Ｃ６アルケニルチオ基、Ｃ３−Ｃ６アルキニルチオ基、Ｃ３−Ｃ６ハロアルケニルチオ基、Ｃ３−Ｃ６ハロアルキニルチオ基、Ｃ２−Ｃ６アルキルカルボニル基、Ｃ２−Ｃ６ハロアルキルカルボニル基、Ｃ２−Ｃ６アルキルカルボニルオキシ基、Ｃ２−Ｃ６アルキルカルボニルチオ基、カルボキシ基、ホルミル基、Ｃ２−Ｃ６アルコキシカルボニル基、ニトロ基、シアノ基、ヒドロキシ基、Ｃ１−Ｃ６アルキルスルホニル基、Ｃ１−Ｃ６ハロアルキルスルホニル基、Ｃ１−Ｃ６アルキルスルフィニル基、Ｃ１−Ｃ６ハロアルキルスルフィニル基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノ基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノスルホニル基またはＣ１−Ｃ６アルキル基を有していてもよいアミノカルボニル基を表し；
Ｒ^５９は、水素原子、Ｃ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ２−Ｃ６アルケニル基、Ｃ２−Ｃ６ハロアルケニル基、Ｃ２−Ｃ６アルキニル基、Ｃ２−Ｃ６ハロアルキニル基、Ｃ３−Ｃ６シクロアルキル基、Ｃ３−Ｃ６ハロシクロアルキル基、Ｃ１−Ｃ６アルコキシ基、Ｃ１−Ｃ６ハロアルコキシ基、Ｃ１−Ｃ６アルキルチオ基、Ｃ１−Ｃ６ハロアルキルチオ基、Ｃ３−Ｃ６シクロアルキルオキシ基、Ｃ３−Ｃ６ハロシクロアルキルオキシ基、Ｃ３−Ｃ６シクロアルキルチオ基、Ｃ３−Ｃ６アルケニルオキシ基、Ｃ３−Ｃ６アルキニルオキシ基、Ｃ３−Ｃ６ハロアルケニルオキシ基、Ｃ３−Ｃ６ハロアルキニルオキシ基、Ｃ３−Ｃ６アルケニルチオ基、Ｃ３−Ｃ６アルキニルチオ基、Ｃ３−Ｃ６ハロアルケニルチオ基、Ｃ３−Ｃ６ハロアルキニルチオ基、Ｃ２−Ｃ６アルキルカルボニル基、Ｃ２−Ｃ６ハロアルキルカルボニル基、Ｃ２−Ｃ６アルキルカルボニルオキシ基、Ｃ２−Ｃ６アルキルカルボニルチオ基、ホルミル基、Ｃ２−Ｃ６アルコキシカルボニル基、ニトロ基、シアノ基、ヒドロキシ基、Ｃ１−Ｃ６アルキルスルホニル基、Ｃ１−Ｃ６ハロアルキルスルホニル基、Ｃ１−Ｃ６アルキルスルフィニル基、Ｃ１−Ｃ６ハロアルキルスルフィニル基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノ基、Ｃ１−Ｃ６アルキル基を有していてもよいアミノスルホニル基またはＣ１−Ｃ６アルキル基を有していてもよいアミノカルボニル基を表す。］

[Wherein R ⁵⁰ , R ⁵¹ , R ⁵² , R ⁵³ , R ⁵⁴ , R ⁵⁵ , R ⁵⁶ , R ⁵⁷ , R ⁵⁸ , R ⁶⁰ , R ⁶¹ , R ⁶² and R ⁶³ are each independently a hydrogen atom , Halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkenyl group, C2-C6 haloalkenyl group, C2-C6 alkynyl group, C2-C6 haloalkynyl group, C3-C6 cycloalkyl group, C3 -C6 halocycloalkyl group, C1-C6 alkoxy group, C1-C6 haloalkoxy group, C1-C6 alkylthio group, C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyloxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3-C Haloalkenyloxy group, C3-C6 haloalkynyloxy group, C3-C6 alkenylthio group, C3-C6 alkynylthio group, C3-C6 haloalkenylthio group, C3-C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group, C2-C6 alkylcarbonylthio group, carboxy group, formyl group, C2-C6 alkoxycarbonyl group, nitro group, cyano group, hydroxy group, C1-C6 alkylsulfonyl Group, C1-C6 haloalkylsulfonyl group, C1-C6 alkylsulfinyl group, C1-C6 haloalkylsulfinyl group, amino group optionally having C1-C6 alkyl group, optionally having C1-C6 alkyl group An aminosulfonyl group or Optionally having 1-C6 alkyl group represents an amino group;
R ⁵⁹ is a hydrogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group, a C2-C6 haloalkenyl group, a C2-C6 alkynyl group, a C2-C6 haloalkynyl group, a C3-C6 cycloalkyl group. Group, C3-C6 halocycloalkyl group, C1-C6 alkoxy group, C1-C6 haloalkoxy group, C1-C6 alkylthio group, C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyl group Oxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3-C6 haloalkenyloxy group, C3-C6 haloalkynyloxy group, C3-C6 alkenylthio group, C3-C6 Alkynylthio group, C3-C6 haloalkenylthio group, C3- C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group, C2-C6 alkylcarbonylthio group, formyl group, C2-C6 alkoxycarbonyl group, nitro group, cyano Group, hydroxy group, C1-C6 alkylsulfonyl group, C1-C6 haloalkylsulfonyl group, C1-C6 alkylsulfinyl group, C1-C6 haloalkylsulfinyl group, amino group optionally having C1-C6 alkyl group, C1- The aminosulfonyl group which may have a C6 alkyl group, or the aminocarbonyl group which may have a C1-C6 alkyl group is represented. ]

The 5- to 10-membered heteroaryl includes one or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as ring constituent atoms, and when two or more atoms are contained, the atoms are the same or phase Represents 5-10 membered heteroaryl, which may be different, including, for example, pyridine, pyrimidine, pyrazine, pyridazine, thiophene, furan, pyrrole, and oxazole.
Examples of 5-10 membered heteroaryloxy groups include pyridyloxy, pyrimidinyloxy, pyrazinyloxy, pyridazinyloxy, thienyloxy, furyloxy, pyrrolyloxy, pyrazolyloxy, imidazolyloxy, thiazolyloxy Group, isothiazolyloxy group, oxazolyloxy group, isoxazolyloxy group, triazolyloxy group, tetrazolyloxy group, oxazoazolyloxy group, thiadiazolyloxy group, benzofuryloxy group , Benzothienyloxy group, indolyloxy group, benzimidazolyloxy group, indazolyloxy group, benzothiazolyloxy group, benzoxazolyloxy group, benzoisothiazolyloxy group, benzoisoxazolyloxy group, Pyrazolopyrrolyloxy group, Lazolopyrazolyloxy group, pyrazoloimidazolyloxy group, imidazopyrimidinyloxy group, imidazopyrazinyloxy group, triazolopyridyloxy group, triazolopyrimidinyloxy group, triazoloquinolyloxy group, 2,3-dihydrobenzofuryloxy Group, 2,3-dihydrobenzothienyloxy group, 1,3-benzodioxolyloxy group, quinolyloxy group, isoquinolyloxy group, cinnolinyloxy group, phthalazinyloxy group, quinazolinyloxy group, Examples thereof include quinoxalinyloxy group, naphthyridinyloxy group, chromanyloxy group, isochromanyloxy group, thienopyridyloxy group, thienopyrazolyloxy group, and thienoquinolyloxy group.

Examples of 5-10 membered heteroarylthio groups include pyridylthio, pyrimidinylthio, pyrazinylthio, pyridazinylthio, thienylthio, furylthio, pyrrolylthio, pyrazolylthio, imidazolylthio, thiazolylthio, isothiazolylthio Group, oxazolylthio group, isoxazolylthio group, triazolylthio group, tetrazolylthio group, oxazoazolylthio group, thiadiazolylthio group, benzofurylthio group, benzothienylthio group, indolylthio group, benzoimidazolylthio group, indazolylthio group, Benzothiazolylthio group, benzoxazolylthio group, benzoisothiazolylthio group, benzoisoxazolylthio group, pyrazolopyrrolylthio group, pyrazolopyrazolylthio group, pyrazoloimidazolylthio group, i Dazopyrimidinylthio group, imidazopyrazinylthio group, triazolopyridylthio group, triazolopyrimidinylthio group, triazoloquinolylthio group, 2,3-dihydrobenzofurylthio group, 2,3-dihydrobenzothienylthio group, 1,3-benzodioxolylthio group, quinolylthio group, isoquinolylthio group, cinnolinylthio group, phthalazinylthio group, quinazolinylthio group, quinoxalinylthio group, naphthyridinylthio group, chromanylthio group, isochromylthio group, thienopyridylthio Group, thienopyrazolylthio group and thienoquinolylthio group.

The 5-10 membered heteroarylamino group represents a group in which one hydrogen atom on the nitrogen of the amino group is substituted with a 5-10 membered heteroaryl group. For example, a pyridylamino group, a pyrimidylamino group, a pyrazylamino group, a pyridazylamino group Group, thienylamino group, furylamino group, pyrrolylamino group, pyrazolylamino group, imidazolylamino group, thiazolylamino group, isothiazolylamino group, oxazolylamino group, isoxazolylamino group, triazolylamino group, tetra Zolylamino group, oxazoazolylamino group, thiadiazolylamino group, benzofurylamino group, benzothienylamino group, indolylamino group, benzoimidazolylamino group, indazolylamino group, benzothiazolylamino group, Benzoxazolylamino group, benzoisothi Zolylamino group, benzisoxazolylamino group, pyrazolopyrrolylamino group, pyrazolopyrazolylamino group, pyrazoloimidazolylamino group, imidazopyrimidylamino group, imidazopyrazylamino group, triazopyridylamino group, triazo Pyrimidylamino group, triazoquinolylamino group, 2,3-dihydrobenzofurylamino group, 2,3-dihydrobenzothienylamino group, 1,3-benzodioxolylamino group, quinolylamino group, isoquino Rylamino group, cinnolinylamino group, phthalazinylamino group, quinazolinylamino group, quinoxalylamino group, naphthyridinylamino group, chromanylamino group, isochromanylamino group, thienopyridylamino group, thieno And pyrazolylamino group and thienoquinolylamino group. .

Examples of the C1-C6 alkyl group include a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a pentyl group, and a hexyl group.
The C1-C6 haloalkyl group represents a group in which at least one hydrogen atom of the C1-C6 alkyl group is substituted with a halogen atom. Fluoromethyl group, trichloromethyl group, tribromomethyl group, chlorofluoromethyl group, dichlorofluoromethyl group, 2,2,2-trifluoroethyl group, 2,2,2-trichloroethyl group, pentafluoroethyl group, chloro Difluoromethyl group, 2,2-difluoroethyl group, 2-chloro-2-fluoroethyl group, 2-chloro-2,2-difluoroethyl group, 2,2-dichloro-2-fluoroethyl group, 2-fluoropropyl Group, 3-fluoropropyl group, 2,2-difluoropropyl group, 3,3,3-trifluoro Propyl group, 3,4-difluoro butyl group, 4-fluoro butyl group, and a 5-fluoropentyl group and 2,2-difluoro-hexyl group.
Examples of the C2-C6 alkenyl group include a vinyl group, 1-propenyl group, isopropenyl group, 2-propenyl group, 1-butenyl group, 1-methyl-1-propenyl group, 2-butenyl group, 1-methyl- 2-propenyl group, 3-butenyl group, 2-methyl-1-propenyl group, 2-methyl-2-propenyl group, 1,3-butadienyl group, 1-pentenyl group, 1-ethyl-2-propenyl group, 2 -Pentenyl group, 1-methyl-1-butenyl group, 3-pentenyl group, 1-methyl-2-butenyl group, 4-pentenyl group, 1-methyl-3-butenyl group, 3-methyl-1-butenyl group, 1,2-dimethyl-2-propenyl group, 1,1-dimethyl-2-propenyl group, 2-methyl-2-butenyl group, 3-methyl-2-butenyl group, 1,2-dimethyl-1-propene Group, 2-methyl-3-butenyl group, 3-methyl-3-butenyl group, 1,3-pentadienyl, 1-vinyl-2-propenyl group, and a 1-hexenyl group and 5-hexenyl.
The C2-C6 haloalkenyl group represents a group in which at least one hydrogen atom of the C2-C6 alkenyl group is substituted with a halogen atom, and examples thereof include a 2-chlorovinyl group, a 2-bromovinyl group, and 2-iodovinyl. Group, 1-trifluoromethylvinyl group, 1-trifluoromethyl-2,2-difluorovinyl group, 3,3-difluoro-2-propenyl group, perfluoro-1-butenyl group, perfluoro-3-butenyl group, perfluoro Examples include a -1-pentenyl group, a perfluoro-4-pentenyl group, a perfluoro-1-hexenyl group, and a perfluoro-5-hexenyl group.
Examples of the C2-C6 alkynyl group include ethynyl group, propargyl group, 3-butyn-2-yl group, 2-butynyl group, 3-butynyl group, 2-methyl-3-butyn-2-yl group, 2- Examples include a pentynyl group, a 3-pentynyl group, a 4-pentynyl group, a 1-hexynyl group, and a 5-hexynyl group.
The C2-C6 haloalkynyl group represents a group in which at least one hydrogen atom of the C2-C6 alkynyl group is substituted with a halogen atom, such as a fluoroethynyl group, 3-chloro-2-propynyl group, 3-bromo -2-propynyl group, 3-iodo-2-propynyl group, 3-chloro-1-propynyl group, 5-chloro-4-pentynyl group, 3,3,3-trifluoro-1-propynyl group, 3,3 , 3-trifluoro-1-propynyl group, perfluoro-2-butynyl group, perfluoro-3-butynyl group, perfluoro-2-pentynyl group, perfluoro-3-pentynyl group, perfluoro-4-pentynyl group, perfluoro-1- Examples include a hexynyl group and a perfluoro-5-hexynyl group.

Examples of the C3-C6 cycloalkyl group include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, and a cyclohexyl group.
The C3-C6 halocycloalkyl group represents a group in which at least one hydrogen atom of the C3-C6 cycloalkyl group is substituted with a halogen atom, for example, a 2-fluorocyclopropyl group, 2,2-difluorocyclopropyl Group, 2-chloro-2-fluorocyclopropyl group, 2,2-dichlorocyclopropyl group, 2,2-dibromocyclopropyl group, 2,2,3,3-tetrafluorocyclobutyl group, 2-chlorocyclopentyl group 2-chlorocyclohexyl group, 4,4-difluorocyclohexyl group and 4-chlorocyclohexyl group.
C1-C6 alkoxy group represents an alkoxy group, for example, methoxy group, ethoxy group, propoxy group, isopropoxy group, butoxy group, isobutoxy group, sec-butoxy group, tert-butoxy group, pentyloxy group, isoamyloxy Group, neopentyloxy group, 2-pentyloxy group, 3-pentyloxy group, 2-methylbutyloxy group, hexyloxy group, isohexyloxy group, 3-methylpentyloxy group and 4-methylpentyloxy group It is done.
The C1-C6 haloalkoxy group represents a group in which at least one hydrogen atom of the C1-C6 alkoxy group is substituted with a halogen atom, such as a trifluoromethoxy group, a trichloromethoxy group, a chloromethoxy group, a dichloromethoxy group. , Fluoromethoxy group, difluoromethoxy group, pentafluoroethoxy group, 2,2,2-trifluoroethoxy group, 2-fluoroethoxy group, 2,2-difluoroethoxy group, heptafluoropropoxy group, 3,3,3- Trifluoropropoxy group, 2-fluoropropoxy group, 3-fluoropropoxy group, 2,2-difluoropropoxy group, 2,3-difluoropropoxy group, 3,3,3-trifluoropropoxy group, nonafluorobutoxy group, Perfluoropentyloxy group and perfluorohexyl Include oxy group.

Examples of the C1-C6 alkylthio group include a methylthio group, an ethylthio group, a propylthio group, an isopropylthio group, a butylthio group, an isobutylthio group, a sec-butylthio group, a tert-butylthio group, a pentylthio group, an isopentylthio group, and a neopentyl group. Ruthio group, isoamylthio group, 2-pentylthio group, 3-pentylthio group, 2-methylbutylthio group, hexylthio group, isohexylthio group, sec-hexylthio group, 3-methylpentylthio group and 4-methylpentylthio group Is mentioned.
The C1-C6 haloalkylthio group represents a group in which at least one hydrogen atom of the linear or branched C1-C6 alkylthio group is substituted with a halogen atom, and examples thereof include a fluoromethylthio group, a difluoromethylthio group, Trifluoromethylthio group, pentafluoroethylthio group, 2,2,2-trifluoroethylthio group, 2,2-difluoroethylthio group, heptafluoropropylthio group, 3,3,3-trifluoropropylthio group, Examples include 2,2-difluoropropylthio group, 3,3,3-trifluoropropylthio group, nonafluorobutylthio group, perfluoropentylthio group and perfluorohexylthio group.

Examples of the C3-C6 cycloalkyloxy group include a cyclopropyloxy group, a cyclobutyloxy group, a cyclopentyloxy group, and a cyclohexyloxy group.
The C3-C6 halocycloalkyloxy group represents a group in which at least one hydrogen atom of the C3-C6 cycloalkyloxy group is substituted with a halogen atom, such as a 2-fluorocyclopropyloxy group, 2,2- Difluorocyclopropyloxy group, 2-chloro-2-fluorocyclopropyloxy group, 2,2-dichlorocyclopropyloxy group, 2,2-dibromocyclopropyloxy group, 2,2-difluoro-1-methylcyclopropyloxy group Group, 2,2-dichloro-1-methylcyclopropyloxy group, 2,2-dibromo-1-methylcyclopropyloxy group, 1- (trifluoromethyl) cyclopropyloxy group, 2,2,3,3- Tetrafluorocyclobutyloxy group, 2-chlorocyclohexyloxy group, 4,4-difluoro Black hexyloxy group and 4-chloro-cyclohexyloxy group.
Examples of the C3-C6 cycloalkylthio group include a cyclopropylthio group, a cyclobutylthio group, a cyclopentylthio group, and a cyclohexylthio group.

Examples of the C2-C6 alkenyloxy group include a vinyloxy group, 2-propenyloxy group, 2-butenyloxy group, 1-methyl-2-propenyloxy group, 3-butenyloxy group, 2-methyl-2-propenyloxy group, 2-pentenyloxy group, 3-pentenyloxy group, 4-pentenyloxy group, 1-methyl-3-butenyloxy group, 1,2-dimethyl-2-propenyloxy group, 1,1-dimethyl-2-propenyloxy group 2-methyl-2-butenyloxy group, 3-methyl-2-butenyloxy group, 2-methyl-3-butenyloxy group, 3-methyl-3-butenyloxy group, 1-vinyl-2-propenyloxy group and 5-hexenyl An oxy group is mentioned.
The C2-C6 haloalkenyloxy group represents a group in which at least one hydrogen atom of the C2-C6 alkenyloxy group is substituted with a halogen atom. 3,3-difluoro-2-propenyloxy group, 4,4,4-trifluoro-2-butenyloxy group, 3,4,4-trifluoro-3-butenyloxy group, 3,3-difluoro-2-methyl- Examples thereof include 2-propenyloxy group, perfluoro-3-butenyloxy group and perfluoro-5-hexenyloxy group.
Examples of the C2-C6 alkynyloxy group include ethynyloxy group, propargyloxy group, 3-butyn-2-yloxy group, 2-butynyloxy group, 3-butynyloxy group, and 2-methyl-3-butyn-2-yloxy group. 2-pentynyloxy group, 3-pentynyloxy group, 4-pentynyloxy group and 5-hexynyloxy group.
The C2-C6 haloalkynyloxy group represents a group in which at least one hydrogen atom of the C2-C6 alkynyloxy group is substituted with a halogen atom. 3-bromo-2-propynyloxy group, 3-iodo-2-propynyloxy group, 5-chloro-4-pentynyloxy group, 3,3,3-trifluoro-1-propynyloxy group, perfluoro-2 -Butynyloxy group, perfluoro-3-butynyloxy group, perfluoro-2-pentynyloxy group, perfluoro-3-pentynyloxy group, perfluoro-4-pentynyloxy group and perfluoro-5-hexynyloxy group.

Examples of the C3-C6 alkenylthio group include a vinylthio group, a 2-propenylthio group, a 2-butenylthio group, a 1-methyl-2-propenylthio group, a 3-butenylthio group, a 2-methyl-2-propenylthio group, 2-pentenylthio group, 3-pentenylthio group, 4-pentenylthio group, 1-methyl-3-butenylthio group, 1,2-dimethyl-2-propenylthio group, 1,1-dimethyl-2-propenylthio group 2-methyl-2-butenylthio group, 3-methyl-2-butenylthio group, 2-methyl-3-butenylthio group, 3-methyl-3-butenylthio group, 1-vinyl-2-propenylthio group and 5-hexenyl A thio group is mentioned.
The C3-C6 haloalkenylthio group represents a group in which at least one hydrogen atom of the C3-C6 alkenylthio group is substituted with a halogen atom, such as a 1-fluorovinylthio group, a 2-fluorovinylthio group, 3-chloro-2-propenylthio group, 3-bromo-2-propenylthio group, 3,3-difluoro-2-propenylthio group, 4,4,4-trifluoro-2-butenylthio group, 3,4, Examples include 4-trifluoro-3-butenylthio group, 3,3-difluoro-2-methyl-2-propenylthio group, perfluoro-3-butenylthio group, and perfluoro-5-hexenylthio group.
Examples of the C3-C6 alkynylthio group include ethynylthio group, propargylthio group, 3-butyn-2-ylthio group, 2-butynylthio group, 3-butynylthio group, 2-methyl-3-butyn-2-ylthio group, Examples include 2-pentynylthio group, 3-pentynylthio group, 4-pentynylthio group, and 5-hexynylthio group.
The C3-C6 haloalkynylthio group represents a group in which at least one hydrogen atom of the C3-C6 alkynylthio group is substituted with a halogen atom, such as a bromoethynylthio group or a 3-chloro-2-propynylthio group. 3-bromo-2-propynylthio group, 3-iodo-2-propynylthio group, 5-chloro-4-pentynylthio group, 3,3,3-trifluoro-1-propynylthio group, perfluoro-2-butynylthio group Group, perfluoro-3-butynylthio group, perfluoro-2-pentynylthio group, perfluoro-3-pentynylthio group, perfluoro-4-pentynylthio group and perfluoro-5-hexynylthio group.

The C2-C6 alkylcarbonyl group is an alkylcarbonyl group having 2 to 6 carbon atoms in total including carbon of the carbonyl, and examples thereof include an acetyl group, a propionyl group, a butanoyl group, a pentanoyl group, and a hexanoyl group. .
The C2-C6 haloalkylcarbonyl group represents a group in which at least one hydrogen atom of the C2-C6 alkylcarbonyl group is substituted with a halogen atom. For example, a trichloroacetyl group, a fluoroacetyl group, a difluoroacetyl group, a trifluoroacetyl group Group, pentafluoropropionyl group, pentachloropropionyl group, pentabromopropionyl group, pentaiodopropionyl group, 3,3,3-trichloropropionyl group, 3,3,3-trifluoropropionyl group, 3,3,3-tri Bromopropionyl group, 3,3,3-triiodopropionyl group, heptafluorobutanoyl group, heptachlorobutanoyl group, heptabromobutanoyl group, heptaiodobutanoyl group, 4,4,4-trifluorobutanoyl group 4,4,4-trichloro Tanoyl group, 4,4,4-tribromobutanoyl group, 4,4,4-triiodobutanoyl group, nonafluoropentanoyl group, nonachloropentanoyl group, nonabromopentanoyl group, nonaiodopentanoyl group And perfluorohexanoyl groups.
The C2-C6 alkylcarbonyloxy group represents an alkylcarbonyloxy group having 2 to 6 carbon atoms in total including carbon of the carbonyl, such as an acetoxy group, a propionyloxy group, a butanoyloxy group, a pentanoyloxy group. Groups and hexanoyloxy groups.
The C2-C6 alkylcarbonylthio group represents a group having 2 to 6 carbon atoms in total including the carbon of the carbonyl. For example, acetylthio group, propionylthio group, butanoylthio group, pentanoylthio group and hexanoylthio group Groups.
C2-C6 alkoxycarbonyl group represents a group having 2 to 6 carbon atoms in total of the alkoxy moiety and carbonyl, such as methoxycarbonyl group, ethoxycarbonyl group, propoxycarbonyl group, isopropoxycarbonyl group, butoxycarbonyl. Group, isobutoxycarbonyl group, sec-butoxycarbonyl group, tert-butoxycarbonyl group, pentyloxycarbonyl group, isoamyloxycarbonyl group, neopentyloxycarbonyl group, 2-pentyloxycarbonyl group, 3-pentyloxycarbonyl group and 2 -A methyl butoxycarbonyl group is mentioned.

Examples of the C1-C6 alkylsulfonyl group include a methylsulfonyl group, an ethylsulfonyl group, a propylsulfonyl group, an isopropylsulfonyl group, a butylsulfonyl group, an isobutylsulfonyl group, a sec-butylsulfonyl group, a tert-butylsulfonyl group, and a pentylsulfonyl group. , Isopentylsulfonyl group, neopentylsulfonyl group, isoamylsulfonyl group, 2-pentylsulfonyl group, 3-pentylsulfonyl group, 2-methylbutylsulfonyl group, hexylsulfonyl group, isohexylsulfonyl group, sec-hexylsulfonyl group, 3 -A methyl pentyl sulfonyl group and a 4-methyl pentyl sulfonyl group are mentioned.
The C1-C6 haloalkylsulfonyl group represents a group in which at least one hydrogen atom of the C1-C6 alkylsulfonyl group is substituted with a halogen atom. For example, a fluoromethylsulfonyl group, a bromodifluoromethylsulfonyl group, a difluoromethylsulfonyl group , Trifluoromethylsulfonyl group, trichloromethylsulfonyl group, tribromomethylsulfonyl group, triiodomethylsulfonyl group, chlorofluoromethylsulfonyl group, pentafluoroethylsulfonyl group, pentachloroethylsulfonyl group, pentabromoethylsulfonyl group, pentaiodo Ethylsulfonyl group, 2,2,2-trichloroethylsulfonyl group, 2,2,2-trifluoroethylsulfonyl group, 2,2,2-trifluoroethylsulfonyl group, 2,2,2- Ribromoethylsulfonyl group, 2,2,2-triiodoethylsulfonyl group, 2,2-difluoroethylsulfonyl group, heptafluoropropylsulfonyl group, heptachloropropylsulfonyl group, heptabromopropylsulfonyl group, heptaiodopropylsulfonyl group 3,3,3-trifluoropropylsulfonyl group, 3,3,3-trichloropropylsulfonyl group, 3,3,3-tribromopropylsulfonyl group, 3,3,3-triiodopropylsulfonyl group, 2, 2-difluoropropylsulfonyl group, 3,3,3-trifluoropropylsulfonyl group, nonafluorobutylsulfonyl group, nonachlorobutylsulfonyl group, nonabromobutylsulfonyl group, nonaiodobutylsulfonyl group, perfluoropentylsulfonyl group Perchlorethylene pentylsulfonyl group, per bromo pentylsulfonyl group, perfluorohexyl sulfonyl group, perchlorethylene hexylsulfonyl group, and a perfluoroalkyl bromohexyl sulfonyl groups and perfluoroalkyl-iodo hexyl sulfonyl group.

Examples of the C1-C6 alkylsulfinyl group include a methylsulfinyl group, an ethylsulfinyl group, a propylsulfinyl group, an isopropylsulfinyl group, a butylsulfinyl group, an isobutylsulfinyl group, a sec-butylsulfinyl group, a tert-butylsulfinyl group, and a pentylsulfinyl group. , Isopentylsulfinyl group, neopentylsulfinyl group, isoamylsulfinyl group, 2-pentylsulfinyl group, 3-pentylsulfinyl group, 2-methylbutylsulfinyl group, hexylsulfinyl group, isohexylsulfinyl group, sec-hexylsulfinyl group, 3 -Methylpentylsulfinyl group and 4-methylpentylsulfinyl group are mentioned.
The C1-C6 haloalkylsulfinyl group represents a group in which at least one hydrogen atom of the C1-C6 alkylsulfinyl group is substituted with a halogen atom. Group, trichloromethylsulfinyl group, pentafluoroethylsulfinyl group, 2,2,2-trifluoroethylsulfinyl group, 2,2-difluoroethylsulfinyl group, heptafluoropropylsulfinyl group, 3,3,3-trifluoropropylsulfinyl group Group, 2,2-difluoropropylsulfinyl group, 3,3,3-trifluoropropylsulfinyl group, nonafluorobutylsulfinyl group, perfluoropentylsulfinyl group and perfluorohexene Shirusurufiniru group, and the like.

The amino group optionally having a C1-C6 alkyl group is an amino group in which one or two hydrogen atoms of the amino group may be substituted with a C1-C6 alkyl group, and in the case of a dialkylamino group The alkyl groups on the nitrogen atom may be the same as or different from each other. Examples of the amino group optionally having a C1-C6 alkyl group include an amino group, an N-methylamino group, an N, N-dimethylamino group, an N-ethylamino group, and an N-ethyl-N-methylamino group. Group, N, N-diethylamino group, N-propylamino group, N-isopropylamino group, N-propyl-N-methylamino group, N, N-dipropylamino group, N, N-diisopropylamino group, N- Examples include a butylamino group, an N-butyl-N-methylamino group, an N, N-dibutylamino group, an N-pentylamino group, an N-pentyl-N-methylamino group, and an N-hexylamino group.
The aminocarbonyl group which may have a C1-C6 alkyl group is an aminocarbonyl group in which one or two hydrogen atoms of the aminocarbonyl group may be substituted with a C1-C6 alkyl group. In the case of an aminocarbonyl group, the alkyl groups on the nitrogen atom may be the same or different from each other. Examples of the aminocarbonyl group optionally having 1-C6 alkyl group include aminocarbonyl group, N-methylaminocarbonyl group, N-ethylaminocarbonyl group, N-propylaminocarbonyl group, N-isopropylaminocarbonyl. Group, N-butylaminocarbonyl group and N-pentylaminocarbonyl group.
The aminosulfonyl group which may have a C1-C6 alkyl group is an aminosulfonyl group in which one or two hydrogen atoms of the aminosulfonyl group may be substituted with a C1-C6 alkyl group, and a dialkyl In the case of an aminosulfonyl group, the alkyl groups on the nitrogen atom may be the same as or different from each other. Examples of the aminosulfonyl group optionally having a C1-C6 alkyl group include an aminosulfonyl group, an N-methylaminosulfonyl group, an N-ethylaminosulfonyl group, an N-propylaminosulfonyl group, and an N-isopropylaminosulfonyl group. Group, N-butylaminosulfonyl group, N-pentylaminosulfonyl group and N-hexylaminosulfonyl group.

Examples of the C1-C4 alkoxy group include a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, an isobutoxy group, a sec-butoxy group, and a tert-butoxy group.
The C1-C4 haloalkoxy group represents a group in which at least one hydrogen atom of the C1-C4 alkoxy group is substituted with a halogen atom. , Fluoromethoxy group, difluoromethoxy group, pentafluoroethoxy group, 2,2,2-trifluoroethoxy group, 2-fluoroethoxy group, 2,2-difluoroethoxy group, heptafluoropropoxy group, 3,3,3-tri Fluoropropoxy group, 2-fluoropropoxy group, 3-fluoropropoxy group, 2,2-difluoropropoxy group, 2,3-difluoropropoxy group, 3,3,3-trifluoropropoxy group and nonafluorobutoxy group It is done.
Examples of the C1-C4 alkylthio group include a methylthio group, an ethylthio group, a propylthio group, an isopropylthio group, a butylthio group, an isobutylthio group, a sec-butylthio group, and a tert-butylthio group.
The C1-C4 haloalkylthio group represents a group in which at least one hydrogen atom of the C1-C4 alkylthio group is substituted with a halogen atom, such as a trifluoromethylthio group, a trichloromethylthio group, a chloromethylthio group, a dichloromethylthio group. , Fluoromethylthio group, difluoromethylthio group, pentafluoroethylthio group, 2,2,2-trichloroethylthio group, 2,2,2-trifluoroethylthio group, 2-fluoroethylthio group, 2,2-difluoro Ethylthio group, heptafluoropropylthio group, 3,3,3-trifluoropropylthio group, 2-fluoropropylthio group, 3-fluoropropylthio group, 2,2-difluoropropylthio group, 2,3-difluoro Propylthio group, 3,3,3-trifluoropropylthio group and It includes nonafluorobutyl thio group.

Examples of the C1-C4 alkylsulfonyl group include a methylsulfonyl group, an ethylsulfonyl group, a propylsulfonyl group, an isopropylsulfonyl group, a butylsulfonyl group, an isobutylsulfonyl group, a sec-butylsulfonyl group, and a tert-butylsulfonyl group.
The C1-C4 haloalkylsulfonyl group represents a group in which at least one hydrogen atom of the C1-C4 alkylsulfonyl group is substituted with a halogen atom, such as a trifluoromethylsulfonyl group, a trichloromethylsulfonyl group, or a chloromethylsulfonyl group. Dichloromethylsulfonyl group, fluoromethylsulfonyl group, difluoromethylsulfonyl group, pentafluoroethylsulfonyl group, 2,2,2-trifluoroethylsulfonyl group, 2-fluoroethylsulfonyl group, 2,2-difluoroethylsulfonyl group, Heptafluoropropylsulfonyl group, 3,3,3-trifluoropropylsulfonyl group, 2-fluoropropylsulfonyl group, 3-fluoropropylsulfonyl group, 2,2-difluoropropylsulfonyl group, 2,3-di Le Oro propylsulfonyl group, 3,3,3-trifluoropropyl sulfonyl group and nonafluorobutylsulfonyl group.

  Examples of the C3-C9 trialkylsilyl group include a trimethylsilyl group, a tert-butyldimethylsilyl group, a triethylsilyl group, an isopropyldimethylsilyl group, and a triisopropylsilyl group.

The C5-C14 trialkylsilylethynyl group represents an ethynyl group to which a trialkylsilyl group is bonded, the total number of carbon atoms including the carbon of the ethynyl group is 5 to 14, and three alkyl groups on the silyl group May be the same or different, for example, trimethylsilylethynyl group, tert-butyldimethylsilylethynyl group, triethylsilylethynyl group, isopropyldimethylsilylethynyl group, triisopropylsilylethynyl group, tri (tert-butyl) silylethynyl group And tributylsilylethynyl group.
Examples of the C1-C4 alkylsulfinyl group include a methylsulfinyl group, an ethylsulfinyl group, a propylsulfinyl group, an isopropylsulfinyl group, a butylsulfinyl group, an isobutylsulfinyl group, a sec-butylsulfinyl group, and a tert-butylsulfinyl group.
The C1-C4 haloalkylsulfinyl group represents a group in which at least one hydrogen atom of the C1-C4 alkylsulfinyl group is substituted with a halogen atom, such as a trifluoromethylsulfinyl group, a trichloromethylsulfinyl group, or a chloromethylsulfinyl group. Dichloromethylsulfinyl group, fluoromethylsulfinyl group, difluoromethylsulfinyl group, pentafluoroethylsulfinyl group, 2,2,2-trifluoroethylsulfinyl group, 2-fluoroethylsulfinyl group, 2,2-difluoroethylsulfinyl group, Heptafluoropropylsulfinyl group, 3,3,3-trifluoropropylsulfinyl group, 2-fluoropropylsulfinyl group, 3-fluoropropylsulfinyl group, 2,2-difluoro B Pils sulfinyl group, 2,3-difluoro-propyl sulfinyl group, and a nonafluorobutyl sulfinyl group.

The C2-C5 alkoxyalkyl group represents a group having 2 to 5 carbon atoms in total of an alkoxy moiety and an alkyl moiety, such as a methoxymethyl group, an ethoxymethyl group, a propoxymethyl group, an isopropoxymethyl group, Butoxymethyl group, isobutoxymethyl group, sec-butoxymethyl group, 1-methoxyethyl group, 2-methoxyethyl group, 2-ethoxyethyl group, 2-propoxyethyl group, 2-isopropoxyethyl group, 2-butoxyethyl Group, 3-methoxypropyl group, 3-ethoxypropyl group and 3-methoxybutyl group.
The C2-C5 alkylthioalkyl group has 2 to 5 carbon atoms in total of the alkylthio moiety and the alkyl moiety, and may be linear or branched. For example, a methoxymethyl group, an ethoxymethyl group, a propoxy group Methyl group, isopropoxymethyl group, butoxymethyl group, isobutoxymethyl group, sec-butoxymethyl group, 1-methoxyethyl group, 2-methoxyethyl group, 2-ethoxyethyl group, 2-propoxyethyl group, 2-iso Examples thereof include a propoxyethyl group, a 2-butoxyethyl group, a 3-methoxypropyl group, a 3-ethoxypropyl group, and a 3-methoxybutyl group.

The C1-C3 haloalkyl group represents a group in which at least one hydrogen atom of the C1-C3 alkyl group is substituted with a halogen atom. For example, a fluoromethyl group, a chloromethyl group, a dichloromethyl group, a difluoromethyl group, a trimethyl group, Fluoromethyl group, trichloromethyl group, tribromomethyl group, chlorofluoromethyl group, dichlorofluoromethyl group, 2,2,2-trifluoroethyl group, 2,2,2-trichloroethyl group, pentafluoroethyl group, chloro Difluoromethyl group, 2,2-difluoroethyl group, 2-chloro-2-fluoroethyl group, 2-chloro-2,2-difluoroethyl group, 2,2-dichloro-2-fluoroethyl group, 2-fluoropropyl Group, 3-fluoropropyl group, 2,2-difluoropropyl group, and 3,3,3-tri Ruoropuropiru group, and the like.
C2-C3 alkenyl groups include vinyl, 1-propenyl, isopropenyl and 2-propenyl groups.
The C2-C3 haloalkenyl group represents a group in which at least one hydrogen atom of the C2-3 alkenyl group is substituted with a halogen atom, such as a 2-chlorovinyl group, 2-bromovinyl group, 2-iodovinyl. Group, 3-chloro-2-propenyl group, 3-bromo-2-propenyl group, 1-chloromethylvinyl group, 2-bromo-1-methylvinyl group, 1-trifluoromethylvinyl group, 3, 3, 3 -Trichloro-1-propenyl group, 3-bromo-3,3-difluoro-1-propenyl group, 2,3,3,3-tetrachloro-1-propenyl group, 1-trifluoromethyl-2,2-difluoro Vinyl group, 2-chloro-2-propenyl group, 3,3-difluoro-2-propenyl group, 2,3,3-trichloro-2-propenyl group, 3,3-dichloro-2-propene Group, include 3,3-dibromo-2-propenyl group and 3-fluoro-3-chloro-2-propenyl group.
C1-C3 alkoxy groups include methoxy, ethoxy, propoxy and isopropoxy groups.

As an aspect of this invention compound, the compound whose substituent in Formula (1) is the following is mentioned, for example.
A tetrazolinone compound in which E is E11. A tetrazolinone compound in which E is E12.
A tetrazolinone compound in which E is E13. A tetrazolinone compound in which E is E14.
A tetrazolinone compound in which E is E15. A tetrazolinone compound in which E is E16.
A tetrazolinone compound in which E is E17. A tetrazolinone compound in which E is E18.
A tetrazolinone compound in which E is E19. A tetrazolinone compound in which E is E20.
A tetrazolinone compound in which E is E21. A tetrazolinone compound in which E is E22.
A tetrazolinone compound in which E is E23. A tetrazolinone compound in which E is E24.
A tetrazolinone compound in which E is E25. A tetrazolinone compound in which E is E26.
A tetrazolinone compound in which E is E27. A tetrazolinone compound in which E is E28.
A tetrazolinone compound in which E is E29. A tetrazolinone compound in which E is E30.
A tetrazolinone compound in which E is E31. A tetrazolinone compound in which E is E32.
A tetrazolinone compound in which E is E33. A tetrazolinone compound in which E is E34.
A tetrazolinone compound in which E is E35. A tetrazolinone compound in which E is E36.
A tetrazolinone compound in which E is E37. A tetrazolinone compound in which E is E38.
A tetrazolinone compound in which E is E39. A tetrazolinone compound in which E is E40.
A tetrazolinone compound in which E is E41. A tetrazolinone compound in which E is E42.
A tetrazolinone compound in which E is E43. A tetrazolinone compound in which E is E44.
A tetrazolinone compound in which E is E45. A tetrazolinone compound in which E is E46.
A tetrazolinone compound in which E is E50. A tetrazolinone compound in which E is E51.
A tetrazolinone compound in which E is E52. A tetrazolinone compound in which E is E53.
A tetrazolinone compound in which E is E54. A tetrazolinone compound in which E is E55.
A tetrazolinone compound in which E is E56. A tetrazolinone compound in which E is E57.
A tetrazolinone compound in which E is E58. A tetrazolinone compound in which E is E59.
A tetrazolinone compound in which E is E60. A tetrazolinone compound in which E is E61.
A tetrazolinone compound in which E is E62. A tetrazolinone compound in which E is E63.
A tetrazolinone compound in which E is E64. A tetrazolinone compound in which E is E65.

Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E11 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E12 . Tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E13 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E14 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E15 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E16 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E17 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E18 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E19 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E20 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E21 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E22 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E23 .

Tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E24 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E26 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E27 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E28 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; . A tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E30 . A tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E31 . A tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E32. . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E33 . Tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E34 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; . Tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E36 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E37 . Tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E38 .

A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E39. . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E40 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; and E is E41. . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E42 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E43 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E44 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E45. . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E46 . A tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E50 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E51 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E52 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E53 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E54 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E55 .

A tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E56 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E57 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E58 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E59 . Tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E60 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E62 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; . Tetrazolinone compound wherein Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E64 . A tetrazolinone compound in which Q is Q46; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E65 .

Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; tetrazolinone compound E is E11. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; tetrazolinone compound E is E12. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; tetrazolinone compound E is E13. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; tetrazolinone compound E is E14. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is E15 tetrazolinone compound. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E16. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; tetrazolinone compound E is E17. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E18. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E19. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E20. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E21. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E22. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E23. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E24. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E25. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E26.

Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E27. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E28. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E29. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E30. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E31. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E32. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E33. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E34. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E35. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E36. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E37. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E38. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; tetrazolinone compound E is E39. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E40. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E41. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E42.

Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E43. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E44. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E45. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E46. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E50. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E51. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E52. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E53. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E54. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E55. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E56. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E57. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E58. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E59. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E60.

Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E61. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E62. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E63. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E64. Q There are at Q61; Y is -O-CH ₂ - ^{is; R 31} is hydrogen atom; ^{R 5} is a methyl group; X is oxygen atom; E is tetrazolinone compound is E65.

〔式中、Ｒ^３０、Ｒ^３１、Ｒ^３２及びＲ^３３は前記と同じ意味を表し、＄はＡとの結合位置を表し、＃はＹとの結合位置を表す。〕であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１１であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１２であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１３であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１４であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１５であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１６であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１７であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１８であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ１９であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^３がメチル基であり；Ｘが酸素原子であり；ＥがＥ２０であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２１であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２２であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２３であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２４であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０およびＲ^３１が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２５であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２６であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２７であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２８であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ２９であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３０であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３１であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３２であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３３であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３４であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３５であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３６であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３７であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３８であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ３９であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ４０であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ４１であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ４２であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ４３であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ４４であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ４５であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ４６であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５０であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５１であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５２であるテトラゾリノン化
合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５３であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５４であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５５であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５６であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５７であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５８であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ５９であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ６０であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ６１であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ６２であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ６３であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ６４であるテトラゾリノン化合物。ＱがＱ４００であり；Ｙが−Ｏ−ＣＨ_２−であり；Ｒ^３０がメチル基であり；Ｒ^３１、Ｒ^３２およびＲ^３３が水素原子であり；Ｒ^５がメチル基であり；Ｘが酸素原子であり；ＥがＥ６５であるテトラゾリノン化合物。Q is the following formula Q400

[Wherein, R ³⁰ , R ³¹ , R ³² and R ³³ represent the same meaning as described above, $ represents a bonding position with A, and # represents a bonding position with Y. Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom Yes; a tetrazolinone compound in which E is E11. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E12. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E13. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E14. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E15. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E16. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E17. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E18. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E19. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ³ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E20. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E21. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E22. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E23. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E24; Tetrazolinone compound in which Q is Q400; Y is —O—CH ₂ —; R ³⁰ and R ³¹ are hydrogen atoms; R ⁵ is a methyl group; X is an oxygen atom; E is E25 . Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E26. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E27. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E28. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E29. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E30. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E31. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E32. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E33; Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E34; Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E35. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E36. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E37. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E38. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E39. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E40. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E41. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E42. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E43. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E44. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E45. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E46. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E50. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E51. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E52. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E53. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E54. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E55. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E56. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E57. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E58. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E59. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E60. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E61. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound in which E is E62; Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound which is an atom and E is E63. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E64. Q is Q400; Y is —O—CH ₂ —; R ³⁰ is a methyl group; R ³¹ , R ³² and R ³³ are hydrogen atoms; R ⁵ is a methyl group; X is oxygen A tetrazolinone compound wherein E is E65.

E is E16, R ⁸ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Y is —O—CH ₂ —, and A may have one or more halogen atoms. A tetrazolinone compound which is a phenyl group, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.
E is E16, R ⁸ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Q is Q46, R ³⁰ and R ³¹ are hydrogen atoms, and Y is —O—CH ₂ —. A tetrazolinone compound in which A is a phenyl group optionally having one or more halogen atoms, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.
E is E16, R ⁸ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Q is Q46, R ³⁰ and R ³¹ are hydrogen atoms, and Y is —O—CH ₂ —. A tetrazolinone compound in which A is a phenyl group optionally having one or more C1-C3 alkoxy groups, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.
E is E16, R ⁸ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Q is Q61, R ³¹ is a hydrogen atom, Y is —O—CH ₂ —, A tetrazolinone compound in which A is an adamantyl group, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.
E is E16, R ⁸ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Q is Q61, R ³¹ is a hydrogen atom, Y is —O—CH ₂ —, A tetrazolinone compound in which A is a phenyl group optionally having one or more halogen atoms, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.

E is E19, R ² and R ³ are hydrogen atoms, Y is —O—CH ₂ —, A is a phenyl group optionally having one or more halogen atoms, and R ⁵ is A tetrazolinone compound which is a C1-C3 alkyl group and X is an oxygen atom.
E is E19, R ² and R ³ are hydrogen atoms, Q is Q46, R ³⁰ and R ³¹ are hydrogen atoms, Y is —O—CH ₂ —, and A is 1 or more. A tetrazolinone compound which is a phenyl group optionally having a halogen atom, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.
E is E19, R ² and R ³ are hydrogen atoms, Q is Q61, R ³¹ is a hydrogen atom, Y is —O—CH ₂ —, and A is one or more halogen atoms. A tetrazolinone compound which is a phenyl group which may have, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.

E is E44, R ⁶ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Y is —O—CH ₂ —, and A may have one or more halogen atoms. A tetrazolinone compound which is a phenyl group, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.
E is E44, R ⁶ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Q is Q46, R ³⁰ and R ³¹ are hydrogen atoms, and Y is —O—CH ₂ —. A tetrazolinone compound in which A is a phenyl group optionally having one or more halogen atoms, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.

E is E51, R ² , R ³ and R ⁴ are hydrogen atoms, Y is —O—CH ₂ —, and A is a phenyl group optionally having one or more halogen atoms, A tetrazolinone compound in which R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.
E is E51, R ² , R ³ and R ⁴ are hydrogen atoms, Q is Q46, R ³⁰ and R ³¹ are hydrogen atoms, Y is —O—CH ₂ —, and A is A tetrazolinone compound which is a phenyl group optionally having one or more halogen atoms, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom.

E is E16, R ⁸ is a C1-C6 alkyl group, R ³ is a hydrogen atom, Q is Q400, R ³⁰ is a C1-C3 alkyl group, R ³¹ , R ³² and R ³³ Is a hydrogen atom, Y is —O—CH ₂ —, A is A17, R ⁵⁰ is a hydrogen atom or a C1-C3 alkyl group, R ⁵¹ is a halogen atom, and R ⁵⁹ is C1- A tetrazolinone compound which is a C3 alkyl group, R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom;
E is E51, R ² , R ³ and R ⁴ are hydrogen atoms, Q is Q400, R ³⁰ is a C1-C3 alkyl group, and R ³¹ , R ³² and R ³³ are hydrogen atoms. Y is —O—CH ₂ —, A is A17, R ⁵⁰ is a hydrogen atom or a C1-C3 alkyl group, R ⁵¹ is a halogen atom, and R ⁵⁹ is a C1-C3 alkyl group. , R ⁵ is a C1-C3 alkyl group, and X is an oxygen atom, a tetrazolinone compound.

〔式中、Ｒ^５、Ｅ、Ａ、Ｑ、Ｘ、およびＧは前記と同じ意味を表し、Ｚ^１１は塩素原子、臭素原子、ヨウ素原子、メタンスルホニルオキシ基、トリフルオロメタンスルホニルオキシ基またはｐ−トルエンスルホニルオキシ基等の脱離基を表し、Ｒ^Ａ１およびＲ^Ａ２は、各々水素原子、ハロゲン原子またはＣ１−Ｃ３アルキル基を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、酢酸エチル、酢酸メチル等のエステル類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、水およびこれらの混合物が挙げられる。
該反応に用いられる塩基としては、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム、水酸化セシウム等のアルカリ金属水酸化物、フッ化ナトリウム、フッ化カリウム、フッ化セシウム等のアルカリ金属ハロゲン化物、水素化リチウム、水素化ナトリウム、水素化カリウム等のアルカリ金属水素化物、ナトリウムｔｅｒｔ−ブトキシド、カリウムｔｅｒｔ−ブトキシドのアルカリ金属アルコキシド等が挙げられる。
該反応には化合物（Ａ１）１モルに対して、化合物（Ａ２）が通常１〜１０モルの割合、塩基が通常０．５〜５モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
該反応は、必要に応じてヨウ化ナトリウム、ヨウ化テトラブチルアンモニウムなどを加えてもよく、これらの化合物は通常、化合物（Ａ１）１モルに対して、０．００１〜１．２モルの割合で用いられる。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（１）を単離することができる。単離された本発明化合物は、クロマトグラフィー、再結晶等によりさらに精製することもできる。Next, the manufacturing method of this invention compound is demonstrated.
The compound of the present invention can be produced, for example, by the following production method.
(Production method A)
Of the compound of the present invention represented by formula (1) (hereinafter referred to as compound (1)), the compound of the present invention represented by formula (1A) is a compound represented by formula (A1) (hereinafter referred to as compound (A1)). And a compound represented by the formula (A2) (hereinafter referred to as compound (A2)) in the presence of a base.

[Wherein R ⁵ , E, A, Q, X, and G represent the same meaning as described above, and Z ¹¹ represents a chlorine atom, a bromine atom, an iodine atom, a methanesulfonyloxy group, a trifluoromethanesulfonyloxy group, or p- A leaving group such as a toluenesulfonyloxy group is represented, and R ^A1 and R ^A2 each represent a hydrogen atom, a halogen atom, or a C1-C3 alkyl group. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, water and mixtures thereof.
Examples of the base used in the reaction include organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene and diazabicyclononene. Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc., lithium hydroxide, sodium hydroxide, Alkali metal hydroxides such as potassium hydroxide and cesium hydroxide, alkali metal halides such as sodium fluoride, potassium fluoride and cesium fluoride, alkali metal hydrides such as lithium hydride, sodium hydride and potassium hydride , Nat Um tert- butoxide, alkali metal alkoxides such as potassium tert- butoxide.
In the reaction, with respect to 1 mol of the compound (A1), the compound (A2) is usually used in a proportion of 1 to 10 mol, and the base is usually used in a proportion of 0.5 to 5 mol.
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
In the reaction, sodium iodide, tetrabutylammonium iodide or the like may be added as necessary, and these compounds are usually in a ratio of 0.001 to 1.2 mol with respect to 1 mol of the compound (A1). Used in
After completion of the reaction, the compound (1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. The isolated compound of the present invention can be further purified by chromatography, recrystallization and the like.

〔式中、Ａ、Ｑ、Ｙ、Ｅ、ＸおよびＲ^５は前記と同じ意味を表し、Ｚ^２１は塩素原子、臭素原子またはヨウ素原子を表し、Ｚ^３１はＢ（ＯＨ）_２、アルコキシボラニル基またはトリフルオロボレート塩（ＢＦ_３ ⁻Ｋ^＋）を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、酢酸エチル、酢酸メチル等のエステル類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、メタノール、エタノール、プロパノール、ブタノール等のアルコール類、水およびこれらの混合物が挙げられる。
化合物（Ｂ２）は、通常市販のものを用いるか、Ｎ． Ｍｉｙａｕｒａ ａｎｄ Ａ． Ｓｕｚｕｋｉ， Ｃｈｅｍ． Ｒｅｖ．，１９９５，９５，２４５７等に記載された公知の方法により製造したものを用いることもできる。該反応に用いられる化合物（Ｂ２）は、例えば、Ａのヨウ素化合物（Ａ−Ｉ）、Ａのブロモ化合物（Ａ−Ｂｒ）またはＡのクロロ化合物（Ａ−Ｃｌ）とブチルリチウムなどのアルキルリチウムとを反応させた後、ホウ酸エステルと反応させることによりボロン酸エステル誘導体を製造することができる。また、前述の反応で得られたボロン酸エステル誘導体を、必要に応じて加水分解することによりボロン酸誘導体を製造することができる。さらに、Ｍｏｌａｎｄｅｒ ｅｔ ａｌ．Ａｃｃ．Ｃｈｅｍ．Ｒｅｓ．，２００７，４０，２７５などに記載された公知の方法に従い、前記ボロン酸エステルをフッ化水素カリウム等でフッ素化することにより、トリフルオロボレート塩（ＢＦ_３ ⁻Ｋ^＋）を得ることもできる。
該反応に用いられる触媒としては、酢酸パラジウム（ＩＩ）、ジクロロビス（トリフェニルホスフィン）パラジウム、テトラキストリフェニルホスフィンパラジウム（０）、パラジウム（ＩＩ）アセテート／トリスシクロヘキシルホスフィン、ビス（ジフェニルホスファンフェロセニル）パラジウム（ＩＩ）ジクロリド、１，３−ビス（２，６−ジイソプロピルフェニル）イミダゾール−２−イリデン（１，４−ナフトキノン）パラジウムダイマー、アリル（クロロ）（１，３−ジメシチル−１，３−ジヒドロ−２Ｈ−イミダゾール−２−イリデン）パラジウムまたはパラジウム（ＩＩ）アセテート／ジシクロヘキシル（２’，４’，６’−トリイソプロピルビフェニル−２−イル）ホスフィン、トリス（ジベンジリデンアセトン）ジパラジウム等が挙げられる。
該反応に用いられる塩基としては、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム、水酸化セシウム等のアルカリ金属水酸化物、フッ化ナトリウム、フッ化カリウム、フッ化セシウム等のアルカリ金属ハロゲン化物、水素化リチウム、水素化ナトリウム、水素化カリウム等のアルカリ金属水素化物、リン酸三カリウム等のアルカリ金属リン酸塩、ナトリウムメトキシド、ナトリウムエトキシド、ナトリウムｔｅｒｔ−ブトキシド、カリウムｔｅｒｔ−ブトキシドのアルカリ金属アルコキシド等が挙げられる。
該反応には化合物（Ｂ１）１モルに対して、化合物（Ｂ２）が通常１〜１０モルの割合、塩基が通常１〜１０モルの割合、触媒が通常０．０００１〜１モルの割合で用いられる。
該反応の反応温度は通常０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（１）を単離することができる。単離された本発明化合物は、クロマトグラフィー、再結晶等によりさらに精製することもできる。(Production method B)
Compound (1) includes a compound represented by formula (B1) (hereinafter referred to as compound (B1)) and a compound represented by formula (B2) (hereinafter referred to as compound (B2)) as a base and It can be produced by subjecting it to a coupling reaction in the presence of a catalyst.

[Wherein, A, Q, Y, E, X and R ⁵ represent the same meaning as described above, Z ²¹ represents a chlorine atom, a bromine atom or an iodine atom, and Z ³¹ represents B (OH) ₂ , alkoxyboranyl. Represents a group or a trifluoroborate salt (BF ₃ ⁻ K ⁺ ). ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, methanol, ethanol, propanol, alcohols such as butanol, water and mixtures thereof.
As the compound (B2), a commercially available compound is generally used. Miyaura and A.M. Suzuki, Chem. Rev. , 1995, 95, 2457, etc., can also be used. The compound (B2) used in the reaction includes, for example, an iodine compound (AI) of A, a bromo compound (A-Br) of A, or a chloro compound (A-Cl) of A and an alkyllithium such as butyllithium. Then, the boronic acid ester derivative can be produced by reacting with boric acid ester. Moreover, a boronic acid derivative can be manufactured by hydrolyzing the boronic acid ester derivative obtained by the above-mentioned reaction as needed. In addition, Molander et al. Acc. Chem. Res. , 2007, 40, 275 and the like, by fluorinating the boronic acid ester with potassium hydrogen fluoride or the like, a trifluoroborate salt (BF ₃ ⁻ K ⁺ ) can also be obtained.
Catalysts used in the reaction include palladium (II) acetate, dichlorobis (triphenylphosphine) palladium, tetrakistriphenylphosphinepalladium (0), palladium (II) acetate / triscyclohexylphosphine, bis (diphenylphosphaneferrocenyl) ) Palladium (II) dichloride, 1,3-bis (2,6-diisopropylphenyl) imidazol-2-ylidene (1,4-naphthoquinone) palladium dimer, allyl (chloro) (1,3-dimesityl-1,3- Dihydro-2H-imidazol-2-ylidene) palladium or palladium (II) acetate / dicyclohexyl (2 ′, 4 ′, 6′-triisopropylbiphenyl-2-yl) phosphine, tris (dibenzylideneacetone) dipalladium And the like.
Examples of the base used in the reaction include organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene and diazabicyclononene. Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc., lithium hydroxide, sodium hydroxide, Alkali metal hydroxides such as potassium hydroxide and cesium hydroxide, alkali metal halides such as sodium fluoride, potassium fluoride and cesium fluoride, alkali metal hydrides such as lithium hydride, sodium hydride and potassium hydride ,Rin Alkali metal phosphates such as tripotassium, sodium methoxide, sodium ethoxide, sodium tert- butoxide, alkali metal alkoxides such as potassium tert- butoxide.
In this reaction, 1 mol of compound (B2) is usually used in a proportion of 1 to 10 mol, a proportion of base is usually 1 to 10 mol, and a catalyst is usually used in a proportion of 0.0001 to 1 mol with respect to 1 mol of compound (B1) It is done.
The reaction temperature is usually in the range of 0 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. The isolated compound of the present invention can be further purified by chromatography, recrystallization and the like.

〔式中、Ａ、Ｑ、Ｙ、Ｅ、Ｘ、Ｒ^５、Ｚ^２１およびＺ^３１は前記と同じ意味を表す。〕
反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、酢酸エチル、酢酸メチル等のエステル類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、水およびこれらの混合物が挙げられる。
化合物（Ｃ２）は、通常、公知の方法で製造したもの、もしくは、市販のものを用いることができる。
該反応に用いられる触媒としては、酢酸パラジウム（ＩＩ）、ジクロロビス（トリフェニルホスフィン）パラジウム、テトラキストリフェニルホスフィンパラジウム（０）、パラジウム（ＩＩ）アセテート／トリスシクロヘキシルホスフィン、ビス（ジフェニルホスファンフェロセニル）パラジウム（ＩＩ）ジクロリド、１，３−ビス（２，６−ジイソプロピルフェニル）イミダゾール−２−イリデン（１，４−ナフトキノン）パラジウムダイマー、アリル（クロロ）（１，３−ジメシチル−１，３−ジヒドロ−２Ｈ−イミダゾール−２−イリデン）パラジウムまたはパラジウム（ＩＩ）アセテート／ジシクロヘキシル（２’，４’，６’−トリイソプロピルビフェニル−２−イル）ホスフィン、トリス（ジベンジリデンアセトン）ジパラジウム等が挙げられる。
該反応に用いられる塩基としては、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム、水酸化セシウム等のアルカリ金属水酸化物、フッ化ナトリウム、フッ化カリウム、フッ化セシウム等のアルカリ金属ハロゲン化物、水素化リチウム、水素化ナトリウム、水素化カリウム等のアルカリ金属水素化物、リン酸三カリウム等のアルカリ金属リン酸塩、ナトリウムメトキシド、ナトリウムエトキシド、ナトリウムｔｅｒｔ−ブトキシド、カリウムｔｅｒｔ−ブトキシドのアルカリ金属アルコキシド等が挙げられる。
該反応には化合物（Ｃ１）１モルに対して、化合物（Ｃ２）が通常１〜１０モルの割合、塩基が通常１〜１０モルの割合、触媒が通常０．０００１〜１モルの割合で用いられる。
該反応の反応温度は通常０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（１）を単離することができる。単離された本発明化合物は、クロマトグラフィー、再結晶等によりさらに精製することもできる。(Production method C)
Compound (1) includes a compound represented by formula (C1) (hereinafter referred to as compound (C1)) and a compound represented by formula (C2) (hereinafter referred to as compound (C2)), a base and It can be produced by subjecting it to a coupling reaction in the presence of a catalyst.

[Wherein, A, Q, Y, E, X, R ⁵ , Z ²¹ and Z ³¹ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, water and mixtures thereof.
As compound (C2), a compound produced by a known method or a commercially available compound can be used.
Catalysts used in the reaction include palladium (II) acetate, dichlorobis (triphenylphosphine) palladium, tetrakistriphenylphosphinepalladium (0), palladium (II) acetate / triscyclohexylphosphine, bis (diphenylphosphaneferrocenyl) ) Palladium (II) dichloride, 1,3-bis (2,6-diisopropylphenyl) imidazol-2-ylidene (1,4-naphthoquinone) palladium dimer, allyl (chloro) (1,3-dimesityl-1,3- Dihydro-2H-imidazol-2-ylidene) palladium or palladium (II) acetate / dicyclohexyl (2 ′, 4 ′, 6′-triisopropylbiphenyl-2-yl) phosphine, tris (dibenzylideneacetone) dipalladium And the like.
Examples of the base used in the reaction include organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene and diazabicyclononene. Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc., lithium hydroxide, sodium hydroxide, Alkali metal hydroxides such as potassium hydroxide and cesium hydroxide, alkali metal halides such as sodium fluoride, potassium fluoride and cesium fluoride, alkali metal hydrides such as lithium hydride, sodium hydride and potassium hydride ,Rin Alkali metal phosphates such as tripotassium, sodium methoxide, sodium ethoxide, sodium tert- butoxide, alkali metal alkoxides such as potassium tert- butoxide.
In this reaction, 1 mol of the compound (C2) is usually used in a proportion of 1 to 10 mol, 1 to 10 mol of the base, and 0.0001 to 1 mol of the catalyst is usually used in the reaction with respect to 1 mol of the compound (C1). It is done.
The reaction temperature is usually in the range of 0 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. The isolated compound of the present invention can be further purified by chromatography, recrystallization and the like.

〔式中、Ａ、Ｑ、Ｙ、Ｅ、Ｘ、Ｒ^５およびＺ^１１は前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、酢酸エチル、酢酸メチル等のエステル類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、水およびこれらの混合物が挙げられる。
該反応に用いられる化合物（Ｅ１）は、通常市販のものを用いることができる。具体的には、クロロジフルオロメタン、臭化メチル、臭化エチル、臭化プロピル、ヨウ化メチル、ヨウ化エチル、ヨウ化プロピル、１，１−ジフルオロ−２−ヨードエタン等のハロゲン化アルキル類、硫酸ジメチル等の硫酸ジアルキル類、ｐ−トルエンスルホン酸メチル、ｐ−トルエンスルホン酸エチル、ｐ−トルエンスルホン酸プロピル、メタンスルホン酸メチル、メタンスルホン酸エチル、メタンスルホン酸プロピル等のアルキルおよびアリールスルホン酸エステル類等が挙げられる。
該反応に用いられる塩基としては、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム、水酸化セシウム等のアルカリ金属水酸化物、フッ化ナトリウム、フッ化カリウム、フッ化セシウム等のアルカリ金属ハロゲン化物、水素化リチウム、水素化ナトリウム、水素化カリウム等のアルカリ金属水素化物、水素化リチウム、水素化ナトリウム、水素化カリウム等のアルカリ金属水素化物、ナトリウムｔｅｒｔ−ブトキシド、カリウムｔｅｒｔ−ブトキシドのアルカリ金属アルコキシド等が挙げられる。
該反応には化合物（１−３）１モルに対して、化合物（Ｅ１）が通常１〜１０モルの割合、塩基が通常１〜１０モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（１）を単離することができる。単離された本発明化合物は、クロマトグラフィー、再結晶等によりさらに精製することもできる。(Production Method D)
Compound (1) includes a compound represented by formula (1-3) (hereinafter referred to as compound (1-3)) and a compound represented by formula (E1) (hereinafter referred to as compound (E1)). Can be prepared by reacting in the presence of a base.

[Wherein, A, Q, Y, E, X, R ⁵ and Z ¹¹ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, water and mixtures thereof.
As the compound (E1) used for the reaction, a commercially available product can be used. Specifically, alkyl halides such as chlorodifluoromethane, methyl bromide, ethyl bromide, propyl bromide, methyl iodide, ethyl iodide, propyl iodide, 1,1-difluoro-2-iodoethane, sulfuric acid Dialkyl sulfates such as dimethyl, alkyl p-toluenesulfonate, ethyl p-toluenesulfonate, propyl p-toluenesulfonate, methyl methanesulfonate, ethyl methanesulfonate, propyl methanesulfonate, and arylsulfonates And the like.
Examples of the base used in the reaction include organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene and diazabicyclononene. Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc., lithium hydroxide, sodium hydroxide, Alkali metal hydroxides such as potassium hydroxide and cesium hydroxide, alkali metal halides such as sodium fluoride, potassium fluoride and cesium fluoride, alkali metal hydrides such as lithium hydride, sodium hydride and potassium hydride ,hydrogen Lithium, sodium hydride, an alkali metal hydride such as potassium hydride, sodium tert- butoxide, alkali metal alkoxides such as potassium tert- butoxide.
In the reaction, with respect to 1 mol of the compound (1-3), the compound (E1) is usually used in a proportion of 1 to 10 mol, and the base is usually used in a proportion of 1 to 10 mol.
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. The isolated compound of the present invention can be further purified by chromatography, recrystallization and the like.

〔式中、Ａ、Ｑ、Ｙ、ＥおよびＲ^５は前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、アセトニトリル、プロピオニトリル等のニトリル類およびこれらの混合物が挙げられる。
該反応に用いられる硫化剤としては五硫化リン、ローソン試薬（２，４−Ｂｉｓ（４−ｍｅｔｈｏｘｙｐｈｅｎｙｌ）−１，３，２，４−ｄｉｔｈｉａｄｉｐｈｏｓｐｈｅｔａｎｅ ２，４−ｄｉｓｕｌｆｉｄｅ）が挙げられる。
該反応には、硫化剤が、化合物（１−Ｏ）１モルに対して好ましくは０．５〜１．５モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
該反応は、必要に応じてピリジンやトリエチルアミンなどの有機塩基、アルカリ金属水酸化物やアルカリ金属炭酸塩などの無機塩基などを加えてもよく、添加する塩基の使用量は化合物（１−Ｏ）に対して０．５〜１．５モルである。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（１−Ｓ）を単離することができる。単離された本発明化合物は、クロマトグラフィー、再結晶等によりさらに精製することもできる。(Production method E)
Of the compound (1), a compound in which X is a sulfur atom (hereinafter referred to as compound (1-S)) is a compound in which X is an oxygen atom in compound (1) (hereinafter referred to as compound (1-O)). It can be produced by reacting a sulfurizing agent.

[Wherein, A, Q, Y, E and R ⁵ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as tellurium, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, nitriles such as acetonitrile, propionitrile, etc. And mixtures thereof.
Examples of the sulfurizing agent used in the reaction include phosphorus pentasulfide and Lawesson's reagent (2,4-bis (4-methoxyphenyl) -1,3,2,4-dithiadiphosphatane 2,4-disulphide).
In the reaction, a sulfiding agent is preferably used at a ratio of 0.5 to 1.5 mol with respect to 1 mol of the compound (1-O).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
In the reaction, if necessary, an organic base such as pyridine or triethylamine, an inorganic base such as an alkali metal hydroxide or an alkali metal carbonate, or the like may be added. The amount of the base to be added is the compound (1-O). It is 0.5-1.5 mol with respect to.
After completion of the reaction, the compound (1-S) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. The isolated compound of the present invention can be further purified by chromatography, recrystallization and the like.

〔式中、Ａ、Ｑ、Ｙ、Ｘ、Ｒ^５、Ｚ^２、Ｚ^３、Ｚ^４およびＺ^３１は前記と同じ意味を表し、Ｚ^４１は塩素原子、臭素原子、ヨウ素原子またはトリフルオロメタンスルホニルオキシ基を表し、Ｒ^７１は
Ｃ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ２−Ｃ６アルケニル基、Ｃ２−Ｃ６ハロアルケニル基、Ｃ２−Ｃ６アルキニル基、Ｃ２−Ｃ６ハロアルキニル基、Ｃ３−Ｃシクロアルキル基、またはＣ３−Ｃ６ハロシクロアルキル基を表す。ただし、Ｚ^２、Ｚ^３およびＺ^４のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。(Production Method F)
Among compounds (1), a compound represented by formula (1-4) (hereinafter referred to as compound (1-4)) is represented by a compound represented by formula (G1) (hereinafter referred to as compound (G1)). ) And a compound represented by formula (G21) (hereinafter referred to as compound (G21)) can be produced by a coupling reaction in the presence of a base and a catalyst.

[Wherein, A, Q, Y, X, R ⁵ , Z ² , Z ³ , Z ⁴ and Z ³¹ represent the same meaning as described above, and Z ⁴¹ represents a chlorine atom, a bromine atom, an iodine atom or trifluoromethanesulfonyloxy. R ⁷¹ represents a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group, a C2-C6 haloalkenyl group, a C2-C6 alkynyl group, a C2-C6 haloalkynyl group, a C3-C cycloalkyl group. Group or a C3-C6 halocycloalkyl group. However, at least one of Z ² , Z ³ and Z ⁴ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｘ、Ｒ^５、Ｚ^１、Ｚ^３、Ｚ^４、Ｚ^３１およびＺ^４１は前記と同じ意味を表し、Ｒ^７２はＣ１−Ｃ３アルキル基を表す。ただし、Ｚ^１、Ｚ^３およびＺ^４のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-5) (hereinafter referred to as compound (1-5)) is represented by a compound represented by formula (G2) (hereinafter referred to as compound (G2)). ) And a compound represented by the formula (G22) (hereinafter referred to as compound (G22)) are subjected to a coupling reaction in the presence of a base and a catalyst.

[Wherein, A, Q, Y, X, R ⁵ , Z ¹ , Z ³ , Z ⁴ , Z ³¹ and Z ⁴¹ represent the same meaning as described above, and R ⁷² represents a C1-C3 alkyl group. However, at least one of Z ¹ , Z ³ and Z ⁴ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^２、Ｚ^４、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。ただし、Ｚ^１、Ｚ^２およびＺ^４のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-6) (hereinafter referred to as compound (1-6)) is represented by a compound represented by formula (G3) (hereinafter referred to as compound (G3)). ) And compound (G22) can be produced by subjecting them to a coupling reaction in the presence of a base and a catalyst.

[Wherein, A, Q, Y, X, R ⁵ , R ⁷² , Z ¹ , Z ² , Z ⁴ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. However, at least one of Z ¹ , Z ² and Z ⁴ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^２、Ｚ^３、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。ただし、Ｚ^１、Ｚ^２およびＺ^３のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-7) (hereinafter referred to as compound (1-7)) is represented by a compound represented by formula (G4) (hereinafter referred to as compound (G4)). And the compound (G22) in the presence of a base and a catalyst in a coupling reaction.

[Wherein, A, Q, Y, X, R ⁵ , R ⁷² , Z ¹ , Z ² , Z ³ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. However, at least one of Z ¹ , Z ² and Z ³ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｙ^２、Ｘ、Ｒ^５、Ｒ^７１、Ｚ^３、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-8) (hereinafter referred to as compound (1-8)) is represented by a compound represented by formula (G5) (hereinafter referred to as compound (G5)). Can be produced by subjecting compound (G21) to a coupling reaction in the presence of a base and a catalyst.

[Wherein, A, Q, Y, Y ² , X, R ⁵ , R ⁷¹ , Z ³ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｙ^２、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-9) (hereinafter referred to as compound (1-9)) is represented by a compound represented by formula (G6) (hereinafter referred to as compound (G6)). And the compound (G22) in the presence of a base and a catalyst in a coupling reaction.

[Wherein, A, Q, Y, Y ² , X, R ⁵ , R ⁷² , Z ¹ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｙ^３、Ｘ、Ｒ^５、Ｒ^７１、Ｚ^２、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-10) (hereinafter referred to as compound (1-10)) is represented by a compound represented by formula (G7) (hereinafter referred to as compound (G7)). Can be produced by subjecting compound (G21) to a coupling reaction in the presence of a base and a catalyst.

[Wherein, A, Q, Y, Y ³ , X, R ⁵ , R ⁷¹ , Z ² , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｙ^３、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-11) (hereinafter referred to as compound (1-11)) is represented by a compound represented by formula (G8) (hereinafter referred to as compound (G8)). And the compound (G22) in the presence of a base and a catalyst in a coupling reaction.

[Wherein, A, Q, Y, Y ³ , X, R ⁵ , R ⁷² , Z ¹ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｙ^１、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^３、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (1-12) (hereinafter referred to as compound (1-12)) is represented by a compound represented by formula (G9) (hereinafter referred to as compound (G9)). And the compound (G22) in the presence of a base and a catalyst in a coupling reaction.

[Wherein, A, Q, Y, Y ¹ , X, R ⁵ , R ⁷² , Z ³ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ａ、Ｑ、Ｙ、Ｙ^１、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^２、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。
製造法Ｂのカップリング反応に代えて、他の公知のカップリング反応を用いることにより、化合物（１）を製造することもできる。Among compounds (1), a compound represented by formula (1-13) (hereinafter referred to as compound (1-13)) is represented by a compound represented by formula (G10) (hereinafter referred to as compound (G10)). And the compound (G22) in the presence of a base and a catalyst in a coupling reaction.

[Wherein, A, Q, Y, Y ¹ , X, R ⁵ , R ⁷² , Z ² , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.
In place of the coupling reaction of Production Method B, compound (1) can also be produced by using another known coupling reaction.

〔式中、Ａ、Ｙ、Ｅ、Ｒ^５、Ｘ、Ｒ^３０、Ｒ^３１およびＺ^３１は前記と同じ意味を表す。〕
反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、酢酸エチル、酢酸メチル等のエステル類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、水およびこれらの混合物が挙げられる。
該反応に用いられる化合物（Ｈ２）は、通常市販のものを用いることができる。
該反応に用いられる触媒としては、酢酸銅、ヨウ化銅、臭化銅、塩化銅、酢酸パラジウム（ＩＩ）、ジクロロビス（トリフェニルホスフィン）パラジウム、テトラキストリフェニルホスフィンパラジウム（０）、パラジウム（ＩＩ）アセテート／トリスシクロヘキシルホスフィン、ビス（ジフェニルホスファンフェロセニル）パラジウム（ＩＩ）ジクロリド、１，３−ビス（２，６−ジイソプロピルフェニル）イミダゾール−２−イリデン（１，４−ナフトキノン）パラジウムダイマー、アリル（クロロ）（１，３−ジメシチル−１，３−ジヒドロ−２Ｈ−イミダゾール−２−イリデン）パラジウムまたはパラジウム（ＩＩ）アセテート／ジシクロヘキシル（２’，４’，６’−トリイソプロピルビフェニル−２−イル）ホスフィン、トリス（ジベンジリデンアセトン）ジパラジウム等が挙げられる。
該反応に用いられる塩基としては、ピリジン、トリエチルアミン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム、水酸化セシウム等のアルカリ金属水酸化物、フッ化ナトリウム、フッ化カリウム、フッ化セシウム等のアルカリ金属ハロゲン化物、水素化リチウム、水素化ナトリウム、水素化カリウム等のアルカリ金属水素化物、リン酸三カリウム等のアルカリ金属リン酸塩、ナトリウムメトキシド、ナトリウムエトキシド、ナトリウムｔｅｒｔ−ブトキシド、カリウムｔｅｒｔ−ブトキシドのアルカリ金属アルコキシド等が挙げられる。
該反応には化合物（Ｈ１）１モルに対して、化合物（Ｈ２）が通常１〜１０モルの割合、塩基が通常１〜１０モルの割合、触媒が通常０．０００１〜１モルの割合で用いられる。
該反応の反応温度は通常０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（１−Ｈ）を単離することができる。単離された本発明化合物は、クロマトグラフィー、再結晶等によりさらに精製することもできる。(Production method G)
Among compounds (1), a compound represented by formula (1-H) in which Q is Q46 (hereinafter referred to as compound (1-H)) is a compound represented by formula (H1) (hereinafter referred to as compound (H1). ) And a compound represented by formula (H2) (hereinafter referred to as compound (H2)) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, A, Y, E, R ⁵ , X, R ³⁰ , R ³¹ and Z ³¹ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, water and mixtures thereof.
As the compound (H2) used in the reaction, a commercially available compound can be used.
The catalyst used in the reaction includes copper acetate, copper iodide, copper bromide, copper chloride, palladium acetate (II), dichlorobis (triphenylphosphine) palladium, tetrakistriphenylphosphine palladium (0), palladium (II). Acetate / triscyclohexylphosphine, bis (diphenylphosphaneferrocenyl) palladium (II) dichloride, 1,3-bis (2,6-diisopropylphenyl) imidazol-2-ylidene (1,4-naphthoquinone) palladium dimer, allyl (Chloro) (1,3-dimesityl-1,3-dihydro-2H-imidazol-2-ylidene) palladium or palladium (II) acetate / dicyclohexyl (2 ′, 4 ′, 6′-triisopropylbiphenyl-2-yl) ) Phosphine, tris (di Nji) dipalladium and the like.
Examples of the base used in the reaction include organic bases such as pyridine, triethylamine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene and diazabicyclononene. Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc., lithium hydroxide, sodium hydroxide, Alkali metal hydroxides such as potassium hydroxide and cesium hydroxide, alkali metal halides such as sodium fluoride, potassium fluoride and cesium fluoride, alkali metal hydrides such as lithium hydride, sodium hydride and potassium hydride ,Rin Alkali metal phosphates such as tripotassium, sodium methoxide, sodium ethoxide, sodium tert- butoxide, alkali metal alkoxides such as potassium tert- butoxide.
In this reaction, 1 mol of compound (H2) is usually used in a proportion of 1 to 10 mol, a proportion of base is usually 1 to 10 mol, and a catalyst is usually used in a proportion of 0.0001 to 1 mol with respect to 1 mol of compound (H1). It is done.
The reaction temperature is usually in the range of 0 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (1-H) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. The isolated compound of the present invention can be further purified by chromatography, recrystallization and the like.

〔式中、Ｒ^Ａ１、Ｒ^Ａ２、Ｙ、Ｅ、Ａ、ＱおよびＸは前記と同じ意味を表し、Ｒ^１０１はＰ^１１、Ｐ^１２またはＰ^１３を表し、Ｒ^９１はＣ１−Ｃ１２アルキル基を表し、Ｚ^１０１は塩素原子または臭素原子を表し、波線は結合部位を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、酢酸エチル、酢酸メチル等のエステル類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類およびこれらの混合物が挙げられる。
該反応に用いられるアジド化剤としては例えばアジ化ナトリウム、アジ化バリウムまたはアジ化リチウム等の無機アジド類、アジ化トリメチルシリル、アジ化ジフェニルホスホリル等の有機アジド類が挙げられる。
該反応には化合物（ＸＡ１）または化合物（ＸＡ２）１モルに対して、アジド化剤が通常１〜１０モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
該反応は、必要に応じて、塩化アルミニウムもしくは塩化亜鉛等のルイス酸を加えてもよく、これらの化合物は通常、化合物（ＸＡ１）または化合物（ＸＡ２）１モルに対して、０．０５〜５モルの割合で用いられる。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＡ３）を単離することができる。単離された化合物（ＸＡ３）は、クロマトグラフィー、再結晶等によりさらに精製することもできる。The method for synthesizing the intermediate compound is described in detail below.
(Reference production method A)
A compound represented by formula (XA3) (hereinafter referred to as compound (XA3)) is a compound represented by formula (XA1) (hereinafter referred to as compound (XA1)) or a compound represented by (XA2) (hereinafter referred to as “XA2”). , Described as Compound (XA2)) and an azidating agent.

[Wherein, R ^A1 , R ^A2 , Y, E, A, Q and X represent the same meaning as described above, R ¹⁰¹ represents P ¹¹ , P ¹² or P ¹³ , and R ⁹¹ represents a C1-C12 alkyl group. Z ¹⁰¹ represents a chlorine atom or a bromine atom, and a wavy line represents a binding site. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, acetonitrile, nitriles and mixtures thereof, such as propionitrile and the like.
Examples of the azidating agent used in the reaction include inorganic azides such as sodium azide, barium azide or lithium azide, and organic azides such as trimethylsilyl azide and diphenylphosphoryl azide.
In the reaction, the azidating agent is usually used at a ratio of 1 to 10 mol per 1 mol of the compound (XA1) or the compound (XA2).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
In this reaction, a Lewis acid such as aluminum chloride or zinc chloride may be added as necessary, and these compounds are usually added in an amount of 0.05 to 5 to 1 mol of compound (XA1) or compound (XA2). Used in molar proportions.
After completion of the reaction, the compound (XA3) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. The isolated compound (XA3) can be further purified by chromatography, recrystallization, and the like.

〔式中、Ｒ^１０１、ＥおよびＸは前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、酢酸エチル、酢酸メチル等のエステル類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類およびこれらの混合物が挙げられる。
該反応に用いられるイソシアナート化剤としては、例えば、ホスゲン、ジホスゲン、トリホスゲン、チオホスゲン、Ｎ，Ｎ−カルボジイミダゾールおよびＮ，Ｎ−チオカルボジイミダゾール等が挙げられる。
該反応には化合物（ＸＢ１）１モルに対して、イソシアナート化剤が通常０．３４〜１０モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
該反応は、必要に応じて、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩等を加えてもよく、これらの化合物は通常、化合物（ＸＢ１）１モルに対して、０．０５〜５モルの割合で用いられる。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＡ１）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method B)
Compound (XA1) can be produced by reacting a compound represented by formula (XB1) (hereinafter referred to as compound (XB1)) with an isocyanate agent.

[Wherein R ¹⁰¹ , E and X represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether and diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane and chlorobenzene, esters such as ethyl acetate and methyl acetate , Ketones such as acetone, methyl ethyl ketone and methyl isobutyl ketone, nitriles such as acetonitrile and propionitrile, and mixtures thereof.
Examples of the isocyanate agent used in the reaction include phosgene, diphosgene, triphosgene, thiophosgene, N, N-carbodiimidazole, N, N-thiocarbodiimidazole, and the like.
In this reaction, an isocyanate agent is usually used in a proportion of 0.34 to 10 mol per 1 mol of compound (XB1).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
The reaction may be carried out by using organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene, diazabicyclononene, etc. , Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, alkali metal bicarbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc. The compound is usually used at a ratio of 0.05 to 5 mol with respect to 1 mol of compound (XB1).
After completion of the reaction, the compound (XA1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^１０１、ＥおよびＺ^１０１は前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、酢酸エチル、酢酸メチル等のエステル類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類およびこれらの混合物が挙げられる。
該反応に用いられるハロゲン化剤としては、例えば、オキシ塩化リン、三塩化リン、五塩化リン、塩化チオニル、オキシ臭化リン、三臭化リン、五臭化リン、三ヨウ化リン、二塩化オキサリル、二臭化オキサリル、トリホスゲン、ジホスゲン、ホスゲンおよび塩化スルフリル等が挙げられる。
該反応には化合物（ＸＣ１）１モルに対して、ハロゲン化剤が通常１〜１０モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
該反応は触媒を加えてもよく、ジメチルホルムアミド等が用いられる。触媒の使用量は、通常、化合物（ＸＣ１）１モルに対して、０．００１〜１モルの割合で用いられる。
該反応は、必要に応じて、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩等を加えてもよく、これらの化合物は通常、化合物（ＸＣ１）１モルに対して、０．０５〜５モルの割合で用いられる。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＡ２）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method C)
Compound (XA2) can be produced by reacting a compound represented by the formula (XC1) (hereinafter referred to as compound (XC1)) with a halogenating agent.

[Wherein R ¹⁰¹ , E and Z ¹⁰¹ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether and diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane and chlorobenzene, esters such as ethyl acetate and methyl acetate , Ketones such as acetone, methyl ethyl ketone and methyl isobutyl ketone, nitriles such as acetonitrile and propionitrile, and mixtures thereof.
Examples of the halogenating agent used in the reaction include phosphorus oxychloride, phosphorus trichloride, phosphorus pentachloride, thionyl chloride, phosphorus oxybromide, phosphorus tribromide, phosphorus pentabromide, phosphorus triiodide, and dichloride. Examples include oxalyl, oxalyl dibromide, triphosgene, diphosgene, phosgene, and sulfuryl chloride.
In the reaction, the halogenating agent is generally used in a proportion of 1 to 10 mol per 1 mol of the compound (XC1).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
In the reaction, a catalyst may be added, and dimethylformamide or the like is used. The amount of the catalyst to be used is generally 0.001 to 1 mol per 1 mol of compound (XC1).
The reaction may be carried out with an organic base such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene, diazabicyclononene as necessary. , Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, alkali metal bicarbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc. The compound is usually used at a ratio of 0.05 to 5 mol with respect to 1 mol of compound (XC1).
After completion of the reaction, the compound (XA2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^１０１、ＥおよびＸは前記と同じ意味を表し、Ｒ^１１１はＣ１−Ｃ１２アルキル基またはフェニル基を表す。〕(Reference production method D)
Compound (XA1) is obtained by reacting compound (XB1) with a carbamate agent to obtain a compound represented by formula (XD1) (hereinafter referred to as compound (XD1)), and then compound (XD1) and isocyanate. It can be produced by reacting with an agent.

[Wherein, R ¹⁰¹ , E and X represent the same meaning as described above, and R ¹¹¹ represents a C1-C12 alkyl group or a phenyl group. ]

A method for producing compound (XD1) from compound (XB1) will be described below.
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, water and mixtures thereof.
Carbamate agents used in the reaction include phenyl chlorocarbonate, methyl chlorocarbonate, ethyl chlorocarbonate, n-propyl chlorocarbonate, isopropyl chlorocarbonate, n-butyl chlorocarbonate, tert-butyl chlorocarbonate, di-tert dicarbonate. -Butyl, dimethyl dicarbonate, diethyl dicarbonate, O-phenyl chlorothioformate, O-methyl chlorothioformate, O-ethyl chlorothioformate and the like.
In the reaction, the carbamate is usually used at a ratio of 1 to 10 moles with respect to 1 mole of the compound (XB1).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
The reaction may be carried out by using organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene, diazabicyclononene, etc. , Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, alkali metal bicarbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc. The compound is usually used at a ratio of 0.05 to 5 mol with respect to 1 mol of compound (XB1).
After completion of the reaction, the compound (XD1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

A method for producing compound (XA1) from compound (XD1) will be described below.
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include ethers such as tetrahydrofuran, dioxane, ethylene glycol dimethyl ether and methyl tert-butyl ether, aromatic hydrocarbons such as toluene and xylene, carbon tetrachloride, chloroform or Halogenated hydrocarbons such as 1,2-dichloroethane and chlorobenzene, nitriles such as acetonitrile, acid amides such as N, N-dimethylformamide, 1,3-dimethyl-2-imidazolidinone and N-methylpyrrolidone, Examples thereof include sulfoxides such as dimethyl sulfoxide, ketones such as acetone, methyl ethyl ketone, and methyl isobutyl ketone, and mixtures thereof.
Examples of the isocyanate agent used in the reaction include phosphorus pentachloride, phosphorus oxychloride, diphosphorus pentoxide, trichlorosilane, dichlorosilane, monochlorosilane, boron trichloride, 2-chloro-1,3,2- Benzodioxaborol, diiodinated silane, methyltrichlorosilane, dimethyldichlorosilane, chlorotrimethylsilane, and the like can be used.
In the reaction, the isocyanate agent is usually used in a proportion of 1 to 10 mol per 1 mol of the compound (XD1).
The reaction temperature is usually in the range of -20 to 250 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
The reaction may be carried out with an organic base such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene, diazabicyclononene as necessary. , Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, alkali metal bicarbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc. The compound is usually used at a ratio of 0.05 to 5 mol per 1 mol of compound (XD1).
After completion of the reaction, the compound (XA1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^１０１およびＥは前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、メタノール、エタノール、プロパノール、ブタノール等のアルコール類、酢酸エチル、酢酸ブチル等のエステル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエ−テル類、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、水およびこれらの混合物が挙げられる。
該反応に用いられる触媒として、パラジウム担持炭素（Ｐｄ／Ｃ）、白金担持炭素（Ｐｔ／Ｃ）、オスミウム担持炭素（Ｏｓ／Ｃ）、ルテニウム担持炭素（Ｒｕ／Ｃ）、ロジウム担持炭素（Ｒｈ／Ｃ）、ラネーニッケル等をあげることができる。
該反応には化合物（ＸＥ１）１モルに対して、触媒が通常０．０００１〜１モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、触媒を濾過後、有機層を濃縮する等の後処理操作を行うことにより、化合物（ＸＢ１）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method E)
The compound represented by the formula (XB1) can be produced by reacting the compound represented by the formula (XE1) (hereinafter referred to as the compound (XE1)) with a catalyst in an excessive amount of hydrogen atmosphere. .

[Wherein R ¹⁰¹ and E represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include alcohols such as methanol, ethanol, propanol and butanol, esters such as ethyl acetate and butyl acetate, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, Halogenated hydrocarbons such as chlorobenzene, ethers such as diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether, anisole, methyl tert-butyl ether, diisopropyl ether, n-heptane, n-hexane , Hydrocarbons such as cyclohexane, n-pentane, toluene, xylene, water, and mixtures thereof.
Catalysts used in the reaction include palladium on carbon (Pd / C), platinum on carbon (Pt / C), osmium on carbon (Os / C), ruthenium on carbon (Ru / C), rhodium on carbon (Rh / C), Raney nickel and the like.
In the reaction, the catalyst is usually used in a proportion of 0.0001 to 1 mol with respect to 1 mol of the compound (XE1).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XB1) can be isolated by performing post-treatment operations such as filtration of the catalyst and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^１０１およびＥは前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、溶媒としては、酢酸等の脂肪族カルボン酸類、メタノール、エタノール等のアルコール類、水およびそれらの混合物が挙げられる。
該反応に用いられる還元剤としては、例えば、鉄、スズ、および亜鉛が挙げられる。
該反応に用いられる酸としては、例えば、塩酸、硫酸、酢酸、および塩化アンモニウム水溶液が挙げられる。
該反応には化合物（ＸＥ１）１モルに対して、還元剤が通常１〜３０モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＢ１）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method F)
Compound (XB1) can be produced by reacting compound (XE1) with a reducing agent in the presence of an acid.

[Wherein R ¹⁰¹ and E represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include aliphatic carboxylic acids such as acetic acid, alcohols such as methanol and ethanol, water, and mixtures thereof.
Examples of the reducing agent used in the reaction include iron, tin, and zinc.
Examples of the acid used in the reaction include hydrochloric acid, sulfuric acid, acetic acid, and an aqueous ammonium chloride solution.
In the reaction, the reducing agent is usually used in a proportion of 1 to 30 mol with respect to 1 mol of the compound (XE1).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XB1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^５、ＸおよびＥはと同じ意味を表し、Ｒ^１９１はＰ^１１またはＰ^１２を表す。〕
該反応は、製造法Ｅに準じて実施することができる。(Reference production method G)
The compound represented by the formula (XG2) (hereinafter referred to as the compound (XG2)) is obtained by combining the compound represented by the formula (XG1) (hereinafter referred to as the compound (XG1)) with the compound (E1). It can manufacture by making it react.

[Wherein R ⁵ , X and E represent the same meaning as R ¹⁹¹ represents P ¹¹ or P ¹² . ]
The reaction can be carried out according to Production Method E.

〔式中、Ｒ^Ａ１、Ｒ^Ａ２、Ｅ、Ｒ^５、Ｚ^２１およびＸは前記と同じ意味を表し、Ｒ^２０１はＰ^５１またはニトロ基を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、フルオロベンゼン、ジフルオロベンゼン、トリフルオロベンゼン、クロロベンゼン、ジクロロベンゼン、トリクロロベンゼン、α，α，α−トリフルオロトルエン、α，α，α−トリクロロトルエン等のハロゲン化炭化水素類、酢酸エチル、酢酸メチル等のエステル類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類およびこれらの混合物が挙げられる。
該反応に用いることができるハロゲン化剤としては、塩素化、臭素化もしくはヨウ素化剤、例えば塩素、臭素、ヨウ素、塩化スルフリル、Ｎ−クロロスクシンイミド、Ｎ−ブロモスクシンイミド、１，３−ジブロモ−５，５−ジメチルヒダントイン、ヨードスクシンイミド、次亜塩素酸ｔｅｒｔ−ブチル、Ｎ−クロログルタルイミド、Ｎ−ブロモグルタルイミド、Ｎ−クロロ−Ｎ−シクロヘキシル−ベンゼンスルホンイミド、Ｎ−ブロモフタルイミド等を挙げることができる。
該反応にはラジカル開始剤を用いることも出来る。
該反応に用いられるラジカル開始剤としては、過酸化ベンゾイル、アゾビスイソブチロニトリル（ＡＩＢＮ）、ジアシルペルオキシド、ジアルキルペルオキシジカルボネート、ｔｅｒｔ−アルキルペルオキシエステル、モノペルオキシカルボネート、ジ（ｔｅｒｔ−アルキルペルオキシ）ケタールおよびケトンペルオキシド等を挙げることができる。
該反応には化合物（ＸＨ１）１モルに対して、ハロゲン化剤が通常１〜１０モルの割合、ラジカル開始剤は通常０．０１〜５モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＨ２）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method H)
A compound represented by formula (XH2) (hereinafter referred to as compound (XH2)) is obtained by reacting a compound represented by formula (XH1) (hereinafter referred to as compound (XH1)) with a halogenating agent. Can be manufactured.

[Wherein, R ^A1 , R ^A2 , E, R ⁵ , Z ²¹ and X represent the same meaning as described above, and R ²⁰¹ represents P ⁵¹ or a nitro group. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ter, anisole, ethers such as methyl tert-butyl ether, diisopropyl ether, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, fluorobenzene, difluorobenzene, trifluorobenzene, chlorobenzene, dichlorobenzene, trichlorobenzene , Α, α, α-trifluorotoluene, halogenated hydrocarbons such as α, α, α-trichlorotoluene, esters such as ethyl acetate and methyl acetate, acetone, methyl ethyl ketone, methyl Ketones such as isobutyl ketone, acetonitrile, nitriles and mixtures thereof, such as propionitrile and the like.
Examples of the halogenating agent that can be used in the reaction include chlorination, bromination or iodination agents such as chlorine, bromine, iodine, sulfuryl chloride, N-chlorosuccinimide, N-bromosuccinimide, 1,3-dibromo-5. , 5-dimethylhydantoin, iodosuccinimide, tert-butyl hypochlorite, N-chloroglutarimide, N-bromoglutarimide, N-chloro-N-cyclohexyl-benzenesulfonimide, N-bromophthalimide and the like. it can.
A radical initiator can also be used for this reaction.
The radical initiator used in the reaction includes benzoyl peroxide, azobisisobutyronitrile (AIBN), diacyl peroxide, dialkylperoxydicarbonate, tert-alkylperoxyester, monoperoxycarbonate, di (tert-alkylperoxy). ) Ketals and ketone peroxides.
In the reaction, the halogenating agent is usually used in a proportion of 1 to 10 mol and the radical initiator is usually used in a proportion of 0.01 to 5 mol with respect to 1 mol of the compound (XH1).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XH2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^Ａ１、Ｒ^Ａ２、Ｅ、Ｒ^１１１、Ｒ^２０１およびＺ^２１は前記と同じ意味を表し、Ｍはナトリウム、カリウム、またはリチウムを表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエ−テル類、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、アセトニトリル、プロピオニトリル等のニトリル類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、メタノール、エタノール、プロパノール、ブタノール等のアルコール類およびこれらの混合物が挙げられる。
該反応に用いることができる化合物（ＸＪ１）としては、ナトリウムメトキシド、ナトリウムエトキシド、ナトリウムプロポキシド、ナトリウムブトキシド、ナトリウムイソプロポキシド、ナトリウムｓｅｃ−ブトキシド、ナトリウムｔｅｒｔ−ブトキシド、カリウムメトキシド、カリウムエトキシド、カリウムプロポキシド、カリウムブトキシド、カリウムイソプロポキシド、カリウムｓｅｃ−ブトキシド、カリウムｔｅｒｔ−ブトキシド、ナトリウムフェノキシド等が挙げられる。
該反応には化合物（ＸＨ２）１モルに対して、化合物（ＸＪ１）が通常１〜１０モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＪ２）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method I)
A compound represented by formula (XJ2) (hereinafter referred to as compound (XJ2)) is reacted with a compound (XH2) and a compound represented by formula (XJ1) (hereinafter referred to as compound (XJ1)). Can be manufactured.

[Wherein, R ^A1 , R ^A2 , E, R ¹¹¹ , R ²⁰¹ and Z ²¹ represent the same meaning as described above, and M represents sodium, potassium or lithium. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include ethers such as diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether, anisole, methyl tert-butyl ether, diisopropyl ether, n-heptane, n -Hydrocarbons such as hexane, cyclohexane, n-pentane, toluene, xylene, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, acetonitrile, propionitrile, etc. Nitriles, N, N-dimethylformamide, 1,3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl Ketones such as butyl ketone, methanol, ethanol, propanol, and mixtures thereof, such as butanol.
Examples of the compound (XJ1) that can be used in the reaction include sodium methoxide, sodium ethoxide, sodium propoxide, sodium butoxide, sodium isopropoxide, sodium sec-butoxide, sodium tert-butoxide, potassium methoxide, potassium ethoxy. And potassium propoxide, potassium butoxide, potassium isopropoxide, potassium sec-butoxide, potassium tert-butoxide, sodium phenoxide and the like.
In the reaction, compound (XJ1) is usually used at a ratio of 1 to 10 mol per 1 mol of compound (XH2).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XJ2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中Ｒ^Ａ１、Ｒ^Ａ２、Ｅ、Ｚ^２１およびＲ^２０１は前記と同じ意味を表す。〕
該反応は、通常、水中もしくは、水を含む溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエ−テル類、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、アセトニトリル、プロピオニトリル等のニトリル類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、メタノール、エタノール、プロパノール、ブタノール等のアルコール類およびこれらの混合物が挙げられる。
該反応に用いられる塩基としては、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、ギ酸リチウム、酢酸リチウム、ギ酸ナトリウム、酢酸ナトリウム、ギ酸カリウム、酢酸カリウム等の金属有機酸塩、硝酸銀、硝酸ナトリウム等の金属硝酸塩、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム、水酸化セシウム等のアルカリ金属水酸化物、ナトリウムメトキシド、ナトリウムエトキシド、ナトリウムｔｅｒｔ−ブトキシド、カリウムｔｅｒｔ−ブトキシドのアルカリ金属アルコキシド等が挙げられる。
該反応には化合物（ＸＨ２）１モルに対して、塩基が通常１〜１００モルの割合で用いられる。
該反応には化合物（ＸＨ２）１モルに対して、水が通常１モル〜大過剰の割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＫ１）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method J)
A compound represented by the formula (XK1) (hereinafter referred to as compound (XK1)) can be produced by reacting compound (XH2) with water in the presence of a base.

[Wherein R ^A1 , R ^A2 , E, Z ²¹ and R ²⁰¹ represent the same meaning as described above. ]
The reaction is usually performed in water or a solvent containing water.
Examples of the solvent used in the reaction include ethers such as diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether, anisole, methyl tert-butyl ether, diisopropyl ether, n-heptane, n -Hydrocarbons such as hexane, cyclohexane, n-pentane, toluene, xylene, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, acetonitrile, propionitrile, etc. Nitriles, N, N-dimethylformamide, 1,3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl Ketones such as butyl ketone, methanol, ethanol, propanol, and mixtures thereof, such as butanol.
Examples of the base used in the reaction include organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene and diazabicyclononene. Metal organic acid salts such as lithium formate, lithium acetate, sodium formate, sodium acetate, potassium formate and potassium acetate, metal nitrates such as silver nitrate and sodium nitrate, alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate and cesium carbonate Salts, alkali metal hydrogen carbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, alkali metal hydroxides such as lithium hydroxide, sodium hydroxide, potassium hydroxide, cesium hydroxide, sodium metho Sid, sodium ethoxide, sodium tert- butoxide, alkali metal alkoxides such as potassium tert- butoxide.
In the reaction, the base is generally used at a ratio of 1 to 100 mol with respect to 1 mol of the compound (XH2).
In the reaction, water is usually used in a proportion of 1 mol to large excess with respect to 1 mol of compound (XH2).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XK1) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^Ａ１、Ｒ^Ａ２、Ｒ^１１１、Ｒ^２０１、ＥおよびＺ^２１は前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、ギ酸、酢酸、トリフルオロ酢酸等の有機酸類、水およびこれらの混合物が挙げられる。
該反応に用いられるハロゲン化剤としては、例えば、塩酸、臭化水素酸、およびヨウ化水素酸が挙げられる。
該反応には化合物（ＸＪ２）１モルに対して、ハロゲン化剤が通常１モル以上の割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＨ２）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method K)
Compound (XH2) can be produced by reacting compound (XJ2) with a halogenating agent.

[Wherein, R ^A1 , R ^A2 , R ¹¹¹ , R ²⁰¹ , E and Z ²¹ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane. Halogenated hydrocarbons such as chlorobenzene, ketones such as acetone, methyl ethyl ketone and methyl isobutyl ketone, nitriles such as acetonitrile and propionitrile, organic acids such as formic acid, acetic acid and trifluoroacetic acid, water and mixtures thereof. Can be mentioned.
Examples of the halogenating agent used in the reaction include hydrochloric acid, hydrobromic acid, and hydroiodic acid.
In the reaction, the halogenating agent is usually used at a ratio of 1 mol or more per 1 mol of the compound (XJ2).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XH2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^Ａ１、Ｒ^Ａ２、Ｒ^２０１、ＥおよびＺ^２１は前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、酢酸エチル、酢酸メチル等のエステル類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、ギ酸、酢酸、トリフルオロ酢酸等の有機酸類、水およびこれらの混合物が挙げられる。
該反応に用いられるハロゲン化剤としては、例えば、臭素、塩素、塩化スルフリル、塩酸、臭化水素酸、ヨウ化水素酸、三臭化ホウ素、三臭化リン、塩化トリメチルシリル、臭化トリメチルシリル、ヨウ化トリメチルシリル、塩化チオニル、臭化チオニル、オキシ塩化リン、三塩化リン、五塩化リン、塩化チオニル、オキシ臭化リン、五臭化リン、三ヨウ化リン、二塩化オキサリル、二臭化オキサリル、塩化アセチル、四臭化炭素、Ｎ−ブロモスクシンイミド、塩化リチウム、ヨウ化ナトリウム、臭化アセチル等が挙げられる。
該反応には化合物（ＸＫ１）１モルに対して、ハロゲン化剤が通常１〜１０モルの割合で用いられる。
該反応を進行させるため、使用するハロゲン化剤によっては添加剤を加える必要があり、具体的には、塩化アセチルに対する塩化亜鉛、四臭化炭素に対するトリフェニルホスフィン、Ｎ−ブロモスクシンイミドに対するジメチルスルフィド、ヨウ化ナトリウムに対する三フッ化ホウ素ジエチルエーテル錯体、臭化アセチルに対する三フッ化ホウ素ジエチルエーテル錯体、塩化リチウムに対するトリエチルアミン及び塩化メタンスルホニル、ヨウ化ナトリウムに対する塩化アルミニウム、ヨウ化ナトリウムに対する塩化トリメチルシリル等が挙げられる。その使用量はいずれの添加剤も、通常、化合物（ＸＫ１）１モルに対して、０．０１〜５モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＨ２）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method L)
Compound (XH2) can be produced by reacting compound (XK1) with a halogenating agent.

[Wherein, R ^A1 , R ^A2 , R ²⁰¹ , E and Z ²¹ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether and diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane and chlorobenzene, esters such as ethyl acetate and methyl acetate , Ketones such as acetone, methyl ethyl ketone and methyl isobutyl ketone, nitriles such as acetonitrile and propionitrile, organic acids such as formic acid, acetic acid and trifluoroacetic acid, water and mixtures thereof.
Examples of the halogenating agent used in the reaction include bromine, chlorine, sulfuryl chloride, hydrochloric acid, hydrobromic acid, hydroiodic acid, boron tribromide, phosphorus tribromide, trimethylsilyl chloride, trimethylsilyl bromide, iodine Trimethylsilyl chloride, thionyl chloride, thionyl bromide, phosphorus oxychloride, phosphorus trichloride, phosphorus pentachloride, thionyl chloride, phosphorus oxybromide, phosphorus pentabromide, phosphorus triiodide, oxalyl dichloride, oxalyl dibromide, chloride Examples include acetyl, carbon tetrabromide, N-bromosuccinimide, lithium chloride, sodium iodide, acetyl bromide and the like.
In the reaction, the halogenating agent is generally used at a ratio of 1 to 10 moles relative to 1 mole of the compound (XK1).
In order to proceed with the reaction, it is necessary to add an additive depending on the halogenating agent used, specifically, zinc chloride for acetyl chloride, triphenylphosphine for carbon tetrabromide, dimethyl sulfide for N-bromosuccinimide, Boron trifluoride diethyl ether complex for sodium iodide, boron trifluoride diethyl ether complex for acetyl bromide, triethylamine and methanesulfonyl chloride for lithium chloride, aluminum chloride for sodium iodide, trimethylsilyl chloride for sodium iodide, etc. . As for the usage-amount, any additive is normally used in the ratio of 0.01-5 mol with respect to 1 mol of compounds (XK1).
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XH2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^Ａ１、Ｒ^Ａ２、ＥおよびＲ^２０１は前記と同じ意味を表し、Ｒ^９０１はＣ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ６−Ｃ１６アリール基、またはＣ６−Ｃ１６ハロアリール基を表し、Ｚ^８０１はフッ素原子、塩素原子、臭素原子またはヨウ素原子を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、アセトニトリル、プロピオニトリル等のニトリル類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類及びこれらの混合物が挙げられる。
該反応に用いられる塩基としては、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム、水酸化セシウム等のアルカリ金属水酸化物、水素化リチウム、水素化ナトリウム、水素化カリウム等のアルカリ金属水素化物、ナトリウムメトキシド、ナトリウムエトキシド、ナトリウムｔｅｒｔ−ブトキシド、カリウムｔｅｒｔ−ブトキシドのアルカリ金属アルコキシド等が挙げられる。
該反応には化合物（ＸＫ１）１モルに対して、化合物（ＸＭ２）が通常１〜１０モルの割合、塩基が通常１〜５モルの割合で用いられる。
該反応の反応温度は通常−２０〜１５０℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
該反応は、必要に応じてヨウ化ナトリウム、ヨウ化テトラブチルアンモニウムなどを加えてもよく、これらの化合物は通常、化合物（ＸＫ１）１モルに対して、０．００１〜１．２モルの割合で用いられる。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＭ３）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method M)
A compound represented by the formula (XM3) (hereinafter referred to as the compound (XM3)) is a compound (XK1) and a generally available compound represented by the formula (XM2) (hereinafter referred to as the compound (XM2)). Can be prepared by reacting in the presence of a base.

[Wherein, R ^A1 , R ^A2 , E and R ²⁰¹ represent the same meaning as described above, and R ⁹⁰¹ represents a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C6-C16 aryl group, or a C6-C16 haloaryl group. Z ⁸⁰¹ represents a fluorine atom, a chlorine atom, a bromine atom or an iodine atom. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as tellurium, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, nitriles such as acetonitrile, propionitrile, etc. N, N-dimethylformamide, 1,3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl Ketones such as butyl ketone and mixtures thereof.
Examples of the base used in the reaction include organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene and diazabicyclononene. Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc., lithium hydroxide, sodium hydroxide, Alkali metal hydroxides such as potassium hydroxide and cesium hydroxide, lithium hydride, sodium hydride, alkali metal hydrides such as potassium hydride, sodium methoxide, sodium ethoxide, sodium tert-butoxide, potassium Alkali metal alkoxides such tert- butoxide.
In the reaction, with respect to 1 mol of the compound (XK1), the compound (XM2) is usually used in a proportion of 1 to 10 mol, and the base is usually used in a proportion of 1 to 5 mol.
The reaction temperature of the reaction is usually in the range of -20 to 150 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
In this reaction, sodium iodide, tetrabutylammonium iodide or the like may be added if necessary, and these compounds are usually in a ratio of 0.001 to 1.2 mol per 1 mol of compound (XK1). Used in
After completion of the reaction, the compound (XM3) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^５０１はＰ^１１、Ｐ^１２、Ｐ^６１またはＰ^６２を表し、Ｒ^５、Ｒ^７１、Ｘ、Ｚ^２、Ｚ^３、Ｚ^４、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。Ｒ^１２１はＣ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロアルキル基、Ｃ２−Ｃ６アルキルカルボニル基、Ｃ２−Ｃ６ハロアルキルカルボニル基、Ｃ２−Ｃ５アルコキシカルボニル基、Ｃ２−Ｃ５ハロアルコキシカルボニル基、ベンジル基またはベンゾイル基（但し、該ベンジル基またはベンゾイル基は、Ｃ１−Ｃ３アルキル基、Ｃ１−Ｃ３ハロアルキル基、ハロゲン原子、およびニトロ基からなる群より選ばれる基で置換されていてもよい。）を表す。ただし、Ｚ^２、Ｚ^３およびＺ^４のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。(Reference production method N)
Among compounds (1), a compound represented by formula (XN12) (hereinafter referred to as compound (XN12)) is a compound represented by formula (XN11) (hereinafter referred to as compound (XN11)) and a formula ( A compound represented by G21) (hereinafter referred to as compound (G21)) can be produced by a coupling reaction in the presence of a base and a catalyst.

[Wherein R ⁵⁰¹ represents P ¹¹ , P ¹² , P ⁶¹ or P ⁶² , and R ⁵ , R ⁷¹ , X, Z ² , Z ³ , Z ⁴ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. . R ¹²¹ is a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkylcarbonyl group, a C2-C6 haloalkylcarbonyl group, a C2-C5 alkoxycarbonyl group, a C2-C5 haloalkoxycarbonyl group, a benzyl group or a benzoyl group ( However, the benzyl group or benzoyl group may be substituted with a group selected from the group consisting of a C1-C3 alkyl group, a C1-C3 haloalkyl group, a halogen atom, and a nitro group. However, at least one of Z ² , Z ³ and Z ⁴ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｘ、Ｒ^５、Ｚ^１、Ｚ^３、Ｚ^４、Ｚ^３１およびＺ^４１は前記と同じ意味を表し、Ｒ^７２はＣ１−Ｃ３アルキル基を表す。ただし、Ｚ^１、Ｚ^３およびＺ^４のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (XN22) (hereinafter referred to as compound (XN22)) is a compound represented by formula (XN21) (hereinafter referred to as compound (XN21)) and a formula ( It can be produced by subjecting a compound represented by G22) (hereinafter referred to as compound (G22)) to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , X, R ⁵ , Z ¹ , Z ³ , Z ⁴ , Z ³¹ and Z ⁴¹ represent the same meaning as described above, and R ⁷² represents a C1-C3 alkyl group. However, at least one of Z ¹ , Z ³ and Z ⁴ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^２、Ｚ^４、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。ただし、Ｚ^１、Ｚ^２およびＺ^４のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among the compounds (1), a compound represented by formula (XN32) (hereinafter referred to as compound (XN32)) is a compound represented by formula (XN31) (hereinafter referred to as compound (XN31)) and a compound ( G22) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , X, R ⁵ , R ⁷² , Z ¹ , Z ² , Z ⁴ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. However, at least one of Z ¹ , Z ² and Z ⁴ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^２、Ｚ^３、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。ただし、Ｚ^１、Ｚ^２およびＺ^３のうち、少なくとも１つは窒素原子を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among the compounds (1), a compound represented by formula (XN42) (hereinafter referred to as compound (XN42)) is a compound represented by formula (XN41) (hereinafter referred to as compound (XN41)). (G22) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , X, R ⁵ , R ⁷² , Z ¹ , Z ² , Z ³ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. However, at least one of Z ¹ , Z ² and Z ³ represents a nitrogen atom. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｙ^２、Ｘ、Ｒ^５、Ｒ^７１、Ｚ^３、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among compounds (1), a compound represented by formula (XN52) (hereinafter referred to as compound (XN52)) is a compound represented by formula (XN51) (hereinafter referred to as compound (XN51)). (G21) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein R ⁵⁰¹ , Y ² , X, R ⁵ , R ⁷¹ , Z ³ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｙ^２、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among the compounds (1), a compound represented by formula (XN62) (hereinafter referred to as compound (XN62)) is a compound represented by formula (XN61) (hereinafter referred to as compound (XN61)). (G22) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , Y ² , X, R ⁵ , R ⁷² , Z ¹ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｙ^２、Ｘ、Ｒ^５、Ｒ^７１、Ｚ^２、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among the compounds (1), a compound represented by formula (XN72) (hereinafter referred to as compound (XN72)) is a compound represented by formula (XN71) (hereinafter referred to as compound (XN71)). (G21) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , Y ² , X, R ⁵ , R ⁷¹ , Z ² , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｙ^３、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^１、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among the compounds (1), a compound represented by formula (XN82) (hereinafter referred to as compound (XN82)) is a compound represented by formula (XN81) (hereinafter referred to as compound (XN81)). (G22) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , Y ³ , X, R ⁵ , R ⁷² , Z ¹ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｙ^１、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^３、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among the compounds (1), a compound represented by the formula (XN92) (hereinafter referred to as the compound (XN92)) is a compound represented by the formula (XN91) (hereinafter referred to as the compound (XN91)). (G22) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , Y ¹ , X, R ⁵ , R ⁷² , Z ³ , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

〔式中、Ｒ^５０１、Ｙ^１、Ｘ、Ｒ^５、Ｒ^７２、Ｚ^２、Ｚ^３１およびＺ^４１は前記と同じ意味を表す。〕
該反応は、製造法Ｂに準じて実施することができる。Among the compounds (1), a compound represented by the formula (XN102) (hereinafter referred to as compound (XN102)) is a compound represented by the formula (XN101) (hereinafter referred to as compound (XN101)). (G22) can be produced by subjecting it to a coupling reaction in the presence of a base and a catalyst.

[Wherein, R ⁵⁰¹ , Y ¹ , X, R ⁵ , R ⁷² , Z ² , Z ³¹ and Z ⁴¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method B.

  Furthermore, by using another known coupling reaction instead of the coupling reaction described in Production Method N, compound (XN12), compound (XN32), compound (XN42), compound (XN52), compound (XN62) ), Compound (XN72), compound (XN82), compound (XN92) and compound (XN102).

〔式中、ＥおよびＲ^９１は前記と同じ意味を表す。〕(Reference production method O)
A compound represented by the formula (XW2) (hereinafter referred to as the compound (XW2)) is a compound represented by the formula (XW1) (hereinafter referred to as the compound (XW1)) in the presence of a reaction accelerator. And XW3) (hereinafter referred to as compound (XW3)).

[Wherein, E and R ⁹¹ represent the same meaning as described above. ]

The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile and mixtures thereof, may also be used compound (XW3) as solvent.
Examples of the compound (XW3) that can be used in the reaction include methanol, ethanol, propyl alcohol, isopropyl alcohol, n-butyl alcohol, sec-butyl alcohol, t-butanol, and n-pentanol.
Examples of the reaction accelerator used in the reaction include mineral acids such as hydrochloric acid and sulfuric acid, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide, N ′-(3-dimethylaminopropyl) -N-ethylcarbodiimide, methanesulfonic acid, and toluenesulfone. Examples thereof include organic acids such as acids, Mitsunobu reaction reagents such as triphenylylphosphine / diethyl azodicarboxylate, thionyl chloride, and boron trifluoride-ethyl ether complex.
In the reaction, the reaction accelerator is usually used in a proportion of 0.01 to 10 mol with respect to 1 mol of the compound (XW1).
The reaction may be carried out by using organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene, diazabicyclononene, etc. , Alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, alkali metal bicarbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, etc. The compound is usually used in a proportion of 0.001 to 5 mol with respect to 1 mol of compound (XW1).
In the reaction, an excess amount of the compound (XW3) is used with respect to the compound (XW1).
The reaction temperature of the reaction is usually in the range of −78 to 100 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XW2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｅ、Ｒ^９１およびＺ^１０１は前記と同じ意味を表す。〕
化合物（ＸＷ１）とハロゲン化剤とを反応させ化合物（ＸＶ１）を製造する方法は、参考製造法Ｃに準じて実施することができる。(Reference production method P)
Compound (XW2) is obtained by reacting compound (XW1) with a halogenating agent to obtain a compound represented by formula (XV1) (hereinafter referred to as compound (XV1)), and then compound (XV1) and compound (XV1). XW3) can be reacted.

[Wherein, E, R ⁹¹ and Z ¹⁰¹ represent the same meaning as described above. ]
The method for producing compound (XV1) by reacting compound (XW1) with a halogenating agent can be carried out according to Reference Production Method C.

The method for producing compound (XW2) from compound (XV1) is described below.
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, and mixtures thereof and the like, may be used compound (XW3) as solvent.
Examples of the compound (XW3) that can be used in the reaction include compounds described in Reference Production Method O.
In the reaction, an excess amount of the compound (XW3) is used with respect to the compound (XV1).
The reaction temperature of the reaction is usually in the range of −78 to 100 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XW2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、ＥおよびＲ^９１は前記と同じ意味を表す。〕
該反応は、通常溶媒中で行われる。
該反応に用いられる溶媒としては、例えば、ｎ−ヘプタン、ｎ−ヘキサン、シクロヘキサン、ｎ−ペンタン、トルエン、キシレン等の炭化水素類、ジエチルエーテル、テトラヒドロフラン、１，４−ジオキサン、エチレングリコ−ルジメチルエ−テル、アニソール、メチルｔｅｒｔ−ブチルエーテル、ジイソプロピルエーテル等のエーテル類、四塩化炭素、クロロホルム、ジクロロメタン、１，２−ジクロロエタン、テトラクロロエタン、クロロベンゼン等のハロゲン化炭化水素類、Ｎ，Ｎ−ジメチルホルムアミド、１，３−ジメチル−２−イミダゾリジノン、Ｎ−メチルピロリドン等の酸アミド類、酢酸エチル、酢酸メチル等のエステル類、ジメチルスルホキシド等のスルホキシド類、アセトン、メチルエチルケトン、メチルイソブチルケトン等のケトン類、アセトニトリル、プロピオニトリル等のニトリル類、水およびこれらの混合物が挙げられる。
該反応に用いることができるアルキル化剤としては、例えばジアゾメタン、トリメチルシリルジアゾメタン、臭化メチル、臭化エチル、臭化プロピル、ヨウ化メチル、ヨウ化エチル、ヨウ化プロピル等のハロゲン化アルキル類、硫酸ジメチル、硫酸ジエチル、硫酸ジプロピル等の硫酸ジアルキル類、ｐ−トルエンスルホン酸メチル、ｐ−トルエンスルホン酸エチル、ｐ−トルエンスルホン酸プロピル、メタンスルホン酸メチル、メタンスルホン酸エチル、メタンスルホン酸ｎ−プロピル等のアルキルまたはアリールスルホン酸エステル類等を挙げることができる。
該反応には化合物（ＸＷ１）１モルに対して、アルキル化剤が通常１〜１０モルの割合で用いられる。
該反応は、必要に応じて、トリエチルアミン、ピリジン、Ｎ−メチルモルホリン、Ｎ−メチルピペリジン、４−ジメチルアミノピリジン、ジイソプロピルエチルアミン、ルチジン、コリジン、ジアザビシクロウンデセン、ジアザビシクロノネン等の有機塩基、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属炭酸塩、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素セシウム等のアルカリ金属炭酸水素塩、テトラブチルアンモニウムヒドロキシド等の４級アンモニウム塩等を加えてもよく、これらの化合物は通常、化合物（ＸＷ１）１モルに対して、０．００１〜５モルの割合で用いられる。
該反応の反応温度は通常−７８〜１００℃の範囲である。該反応の反応時間は通常０．１〜２４時間の範囲である。
反応終了後は、反応混合物を有機溶媒で抽出し、有機層を乾燥、濃縮する等の後処理操作を行うことにより、化合物（ＸＷ２）を単離することができる。さらに蒸留、クロマトグラフィー、再結晶等の操作で精製してもよい。(Reference production method Q)
Compound (XW2) can be produced by reacting compound (XW1) with an alkylating agent.

[Wherein, E and R ⁹¹ represent the same meaning as described above. ]
The reaction is usually performed in a solvent.
Examples of the solvent used in the reaction include hydrocarbons such as n-heptane, n-hexane, cyclohexane, n-pentane, toluene, xylene, diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether. Ethers such as ter, anisole, methyl tert-butyl ether, diisopropyl ether, halogenated hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, tetrachloroethane, chlorobenzene, N, N-dimethylformamide, 1 , 3-dimethyl-2-imidazolidinone, acid amides such as N-methylpyrrolidone, esters such as ethyl acetate and methyl acetate, sulfoxides such as dimethyl sulfoxide, acetone, methyl ethyl ketone, methyl isobutyl ketone Ketones such as down, nitriles such as acetonitrile and propionitrile, water and mixtures thereof.
Examples of the alkylating agent that can be used in the reaction include alkyl halides such as diazomethane, trimethylsilyldiazomethane, methyl bromide, ethyl bromide, propyl bromide, methyl iodide, ethyl iodide, propyl iodide, and sulfuric acid. Dialkyl sulfates such as dimethyl, diethyl sulfate and dipropyl sulfate, methyl p-toluenesulfonate, ethyl p-toluenesulfonate, propyl p-toluenesulfonate, methyl methanesulfonate, ethyl methanesulfonate, n-propyl methanesulfonate Alkyl or aryl sulfonic acid esters such as
In the reaction, the alkylating agent is usually used at a ratio of 1 to 10 moles relative to 1 mole of the compound (XW1).
The reaction may be carried out by using organic bases such as triethylamine, pyridine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine, diisopropylethylamine, lutidine, collidine, diazabicycloundecene, diazabicyclononene, etc. 4 such as alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, alkali metal hydrogen carbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium hydrogen carbonate, tetrabutylammonium hydroxide, etc. A quaternary ammonium salt or the like may be added, and these compounds are usually used in a proportion of 0.001 to 5 mol with respect to 1 mol of the compound (XW1).
The reaction temperature of the reaction is usually in the range of −78 to 100 ° C. The reaction time is usually in the range of 0.1 to 24 hours.
After completion of the reaction, the compound (XW2) can be isolated by performing post-treatment operations such as extraction of the reaction mixture with an organic solvent, and drying and concentration of the organic layer. Further, purification may be performed by operations such as distillation, chromatography, recrystallization and the like.

〔式中、Ｒ^Ａ１、Ｒ^Ａ２、Ｇ、Ｅ、Ａ、ＱおよびＺ^１１は前記と同じ意味を表す。〕
該反応は、製造法Ａに準じて実施することができる。(Reference production method T)
The compound represented by the formula (XS2) (hereinafter referred to as the compound (XS2)) is obtained by combining the compound represented by the formula (XS1) (hereinafter referred to as the compound (XS1)) with the compound (A2). It can manufacture by making it react under.

[Wherein, R ^A1 , R ^A2 , G, E, A, Q and Z ¹¹ represent the same meaning as described above. ]
The reaction can be carried out according to Production Method A.

  The form of the compound of the present invention may be the compound of the present invention alone. Usually, the compound of the present invention is mixed with a solid carrier, a liquid carrier, a surfactant, etc., and if necessary, a fixing agent or a dispersing agent. Additives for preparations such as stabilizers, wettable powder, granular wettable powder, flowable powder, granules, dry flowable powder, emulsion, aqueous liquid, oil, smoke, aerosol, micro It is used in the form of capsules. These preparations usually contain 0.1 to 99%, preferably 0.2 to 90% by weight of the compound of the present invention.

  Examples of the solid carrier include clays (for example, kaolin, diatomaceous earth, synthetic hydrous silicon oxide, fusami clay, bentonite, acidic clay), talc, and other inorganic minerals (for example, sericite, quartz powder, sulfur powder, activated carbon, Examples of the liquid carrier include water, alcohols (e.g., methanol, ethanol), ketones (e.g., acetone, Methyl ethyl ketone), aromatic hydrocarbons (eg, benzene, toluene, xylene, ethylbenzene, methylnaphthalene), aliphatic hydrocarbons (eg, n-hexane, cyclohexanone, kerosene), esters (eg, ethyl acetate, butyl acetate) ), Nitriles (eg acetonitrile, isobutyronitrile), ethers (eg , Dioxane, diisopropyl d - ether), acid amides (e.g., DMF, dimethylacetamide), halogenated hydrocarbons (e.g., dichloroethane, trichlorethylene, carbon tetrachloride) and the like.

  Examples of the surfactant include alkyl sulfates, alkyl sulfonates, alkyl aryl sulfonates, alkyl aryl ethers and polyoxyethylene compounds thereof, polyoxyethylene glycol ethers, polyvalent Examples include alcohol esters and sugar alcohol derivatives.

  Other formulation adjuvants include, for example, fixing agents and dispersants, specifically casein, gelatin, polysaccharides (eg starch, arabic gum, cellulose derivatives, alginic acid), lignin derivatives, bentonite, saccharides, synthetic water solutions. Polymers (for example, polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acids), PAP (isopropyl acid phosphate), BHT (2,6-di-tert-butyl-4-methylphenol), BHA (2- and a mixture of tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol), vegetable oils, mineral oils, fatty acids or esters thereof.

The method of applying the control agent of the present invention is not particularly limited as long as the control agent of the present invention can be applied substantially, but for example, treatment to plant bodies such as foliage spraying, plant such as soil treatment, etc. And the like, and the treatment of seeds such as seed disinfection.
Moreover, you may use this invention control agent in mixture with various oils, such as mineral oil and vegetable oil, or surfactant. Oils that can be used specifically mixed, surfactants include Nimbus (registered trademark), Assist (registered trademark), Aureo (registered trademark), Iharol (registered trademark), Silwet L-77 (registered trademark), BreakThru (registered trademark), Sundance II (registered trademark), Induce (registered trademark), Penetrator (registered trademark), AgriDex (registered trademark), Lutensol A8 (registered trademark), NP-7 (registered trademark), Triton (registered trademark) , Nufilm (registered trademark), Emulator NP7 (registered trademark), Emulad (registered trademark), TRITON X 45 (registered trademark), AGRAL 90 (registered trademark), AGROTIN (registered trademark), ARPON (registered trademark), EnSpray N (registered trademark) Trademark) And the like BANOLE (registered trademark).

The application amount of the present control agent varies depending on weather conditions, formulation form, application time, application method, application location, target disease, target crop, etc., but the amount of the present compound in the present control agent per 1000 m ² , Usually 1 to 500 g, preferably 2 to 200 g. Emulsions, wettable powders, suspensions and the like are usually diluted with water and applied. In this case, the concentration of the compound of the present invention after dilution is usually 0.0005 to 2% by weight, preferably 0.005 to 1. The powder, granules and the like are usually applied as they are without dilution. In the seed treatment, the amount of the compound of the present invention in the control agent of the present invention is usually 0.001 to 100 g, preferably 0.01 to 50 g per 1 kg seed.
The control agent of the present invention can be used as a pest control agent in agricultural land such as fields, paddy fields, lawns, orchards. The control agent of the present invention can control diseases of the farmland in the farmland where the “plants” and the like listed below are cultivated.

In another embodiment, for example, by administering the compound of the present invention to the inside (in the body) or outside (the body surface) of the vertebrate, the organism or parasite that parasitizes the vertebrate is systemically or non-systemically. Can be disinfected. Examples of such internal administration include oral administration, anal administration, transplantation, subcutaneous, intramuscular and intravenous administration by injection. External administration includes transdermal administration. Moreover, it is possible to feed domestic animals and control sanitary pests generated in the excrement of the animals.
When the compound of the present invention is treated on animals such as livestock and pets that are parasitized with pests, the dosage can be varied widely depending on the administration method, etc. It is desirable to administer the active ingredient (the compound of the present invention or a salt thereof) at a concentration of 0.1 mg to 2000 mg, preferably 0.5 mg to 1000 mg.

The compound of the present invention can be used as a pest control agent in agricultural land such as fields, paddy fields, lawns, orchards. The compound of the present invention can control diseases of the cultivated land in the cultivated lands where the “plants” and the like listed below are cultivated.
Agricultural crops: corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, peanuts, buckwheat, sugar beet, rapeseed, sunflower, sugarcane, tobacco, etc., vegetables; solanaceous vegetables (eggplants, tomatoes, peppers) , Peppers, potatoes, etc.), cucurbitaceae vegetables (cucumber, pumpkin, zucchini, watermelon, melon, etc.), cruciferous vegetables (radish, turnip, horseradish, cold rabi, Chinese cabbage, cabbage, mustard, broccoli, cauliflower, etc. ), Asteraceae vegetables (burdock, garlic, artichoke, lettuce, etc.), Liliaceae vegetables (green onion, onion, garlic, asparagus), Aceraceae vegetables (carrot, parsley, celery, American red pepper, etc.), Akaza Vegetables (spinach, chard, etc.), perilla vegetables (perilla, mint, basil) ), Strawberry, sweet potato, yam, taro, etc., flowers, foliage plants,
Fruit trees; pears (apples, pears, Japanese pears, quince, quince, etc.), nuclear fruits (peaches, plums, nectarines, ume, sweet cherry, apricots, prune, etc.), citrus fruits (Satsuma mandarin, orange, lemon, lime) , Grapefruit, etc.), nuts (chestnut, walnut, hazel, almond, pistachio, cashew nut, macadamia nut, etc.), berries (blueberry, cranberry, blackberry, raspberry, etc.), Grape, oyster, olive, loquat, banana, coffee, date palm, coconut palm, etc.
Trees other than fruit trees; tea, mulberry, flowering trees, street trees (ash, birch, dogwood, eucalyptus, ginkgo, lilac, maple, oak, poplar, redwood, fu, sycamore, zelkova, black bean, peach tree, tsuga, rat, Pine, spruce, yew).
The “plant” includes genetically modified crops.

Examples of pests that can be controlled by the compounds of the present invention include phytopathogenic fungi such as filamentous fungi, harmful arthropods such as harmful insects and harmful ticks, and linear animals such as nematodes, The following can be mentioned in detail, but is not limited to these.
Rice blast (Magnaporthe grisea), sesame leaf blight (Cochliobolus miyabeanus), blight (Rhizoctonia solani), idiotic seedling (Gibberella fujikuroi), yellow rot Graminis), Fusarium Graminearum, F. avenaceum, F. culmorum, Microdochium nivare, Rust (Puccinia striformis), P. graminis, P. reconditis Nuclear disease (Typhula sp. , Naked scab (Ustilago tritici), Tuna scab (Tilletia caries, T. controversa), eye spot disease (Pseudocercosporella herpotrichoides), leaf blight (Septoria tritium) -Repentis, Rhizotonia solani, Blight (Gaeumanomyces graminis); Barley powdery mildew (Erysipheumuminum, Fusarium magnum. Fusarium var.). Microdo Him nivale, rust disease (Puccinia striiformis, P. graminis, P. hordei), naked smut (Ustylago nuda), cloud disease (Rhynchosporis saris), reticulophor spot (Pyrephorphor spot) Leaf disease (Pyrenophora graminea), Ramularia disease (Ramularia collo-cygni), Rhizoctonia sorghum (Puccinia sorghi), psoriasis disease Setosphaeria turica), sesame leaf blight (Cochli) oboleus heterotrophus, anthracnose (Colletotrichum graminicola), gray leaf spot disease (Cercospora zeae-maydis), brown spot disease (Kabatiella zeaerum) disease, Phaeosfarea leaf disease gossypii), mildew (Ramuraria areola), black spot (Alternaria macrospora, A.). gossypii);

Rust of coffee (Hemileia vastatrix); Sclerotinia sclerotia of rapeseed, black spot (Alternaria brassicae), phoenosis of citrus (Diapoetia, diapoetia) ), Fruit rot (Penicillium digitatum, P. italicum); apple monilia (Monilinia mali), rot (Valsa ceratosperma), powdery mildew (Podophaera leukotria), spotted leaf disease, Alptera terpata. (Venturia naequalis), anthracnose (Glomerella cingulata); pear black scab (Venturia nashiticola, V. pirina), black spot (Alternaria alternaum anemuumum) ), Black scab (Cladosporium carpophilum), pomopsis spoilage (Phomopsis sp.); Grape black scab (Elsinoe ampelina), late rot (Glomerella cingulata), powdery mildew (Uncinulaporpick) sidis, black lot disease (Guignardia bidwellii), downy mildew (Plasmopara viticola); oyster anthracnose (Gloeosporium kakii), deciduous leaf disease (Cercospora kakii, Mycosphaerellato) Powdery mildew (Sphaerotheca furiginea), Vine blight (Didymella bryoniae), Brown spot (Corynspora casiicola), Vine split disease (Fusarium oxysporum), Downy mildew (Pseudosoporhos disease) ), Seedling blight (Pythium sp.);

Ring rot of tomato (Alternaria solani), leaf mold (Cladosporium fulvum), scab (Pseudocercospora fuligena), plague (Phytophorhora infestans); Black spot disease (Alternaria japonica), white spot disease (Cercosporella brassicae), root-knot disease (Plasmodiophora brassicae), downy mildew (Peronospora parasitica); i), black pepper (Elsinoe glycines), sunspot disease (Diaporthe phaseolum var. sojae), rust (Phokopsora pachyritolici), brown ring disease (Corynespora citalico citrus circo). Disease (Rhizoctonia solani), brown leaf disease (Septoria glycines), spot disease (Cercospora sojina); bean anthracnose (Colletotrichum colcoor cercospor disease) Silk disease (S pea powdery mildew (Erysiphe pisii); potato summer blight (Alternaria solani), blight (Phytophthora infestans, Strawberry varieties), Verticillium albodrum. Sphaerotheca humuli; Chamodium rot (Exobasidium reticulatum), white scab (Elsinoe leucospila), ring spot (Pestalotisis pneumoniae), and anthracnose (Colletotrichuminthae) ), Udon Diseases (Erysiphe cichoracerum), Anthracnose (Colletotrichum tabacum), Downy mildew (Peronosporata tabacumina), Blight (Phytophthora nichotiana leaf) (Cercosporacetic leaf disease) cucumeris, black root disease (Aphanomyces cochlioides); rose black spot disease (Diplocarpon rosae); powdery mildew (Sphaerotheca pannosain); Blight of onion (Botrytis cinerea, B .; byssoidea, B.M. squamosa), gray rot (Botrytis alli), small sclerotia rot (Botrytis squamosa); various crops of gray rot (Bottrytis cinereaol), sclerotia sclerotia varieties (Sclerotinia sclerotia) Shiva dara-spot disease (Sclerotinia homeocarpa); Shiba brown patch disease and radipatch disease (Rhizotonia solani);

Hemiptera: small brown planthopper (Laodelphax striatellus), brown planthopper (Nilaparvata lugens), Sejirounka (Sogatella furcifera) planthoppers such as, green rice leafhopper (Nephotettix cincticeps), Taiwan green rice leafhopper (Nephotettix virescens) leafhoppers such as, cotton aphid (Aphis gossypii) , Peaches aphids (Myzus persicae), radish aphids (Brevicorine brassicae), tulip beetle aphids (Macrosiphum euphorbiae), potato aphids (Aulacorthum solani), wheat Aphids such as Rhapalosiphum padi and Toxoptera citricicidus, Nezara tentenis, eus isch, Riptortus clavetus , Larvae (Halyomorpha mista), stink bugs such as tanned plant bug (Lygus lineolaris), Trialureodes vaporiarum, silver leaf whiteflies (Bemisia foliage, etc.) Boiled scale (Aonidiella aurantii), San Jose scaled scale (Comstockcaspis perniciosa), Citrus snow scale (Unaspis citris), Iceria scales, Iceria phylumidum

Lepidoptera: rice stem borer (Chilo suppressalis), Sankameiga (Tryporyza incertulas), leaf roller (Cnaphalocrocis medinalis), Watanomeiga (Notarcha derogata), Indian meal moth (Plodia interpunctella), the European corn borer (Ostrinia furnacalis), high Madara Roh moth (Hellula undalis), Japanese medusa such as Shibata toga (Pediasia teterrellus), Spodoptera litura, Spodoptera exigua, Ayuyotoga (Pseudaletia sepata), Atoga assicae), Agrotis ipsilon, Tamanaginawaba (Prusia nigrisigna), Trichopulsia, Heliotis, Helicoberpa, etc. Leguminova glycinnivorella), Azusa yamashiga (Matsumuraeses azukivivora), Apple wolfberry (Adoxophyces orana moss) Fusocopreanus, Cydia pomonella, and other species, Euphoria of the genus Cyptolia, Cypridia isp, etc. Species of the genus Curtis, Suga such as Plutella xylostella, Pterophora gossypiella potato moth (Phthorimaea operculella), and the like anslucens), webbing clothes moth (Tineola bisselliella) Hirozukoga such as such.
Thysanoptera: western flower thrips (Frankliniella occidentalis), Minami thrips (Thrips palmi), yellow tea thrips (Scirtothrips dorsalis), green onion thrips (Thrips tabaci), Hirazuhanaazamiuma (Frankliniella intonsa), tobacco thrips (Frankliniella fusca) thrips, such as Etc.
Diptera: Housefly (Musca domestica), Culex (Culex pipiens pallens), gadfly (Tabanus trigonus), onion maggot (Hylemya antiqua), seedcorn maggot (Hylemya platura), Anopheles sinensis (Anopheles sinensis), rice leafminer (Agromyza oryzae), rice Hydrelia griseola, Bluefly flies (Chloropsoryzae), Dwarf fly (Dacus cucurbitae), Ceratitis capitata, B. riparii folii folii.

Coleoptera: beetle, Epilachna vigintioctopunctata (Epilachna vigintioctopunctata), cucurbit leaf beetle (Aulacophora femoralis), Kisujinomihamushi (Phyllotreta striolata), Inedorooimushi (Oulema oryzae), rice weevil (Echinocnemus squameus), rice water weevil (Lissorhoptrus oryzophilus), boll weevil (Anthonomus grandis), Azuki beetle (Callosobruchus chinensis), Shibahorusu weevil (Sphenophorus venatus), Japanese beetle (Popilia japonica), Douganebububu (Anomala cupre) ), Corn rootworm mate (Diabrotica spp.), Colorado potato beetle (Leptinotarsa decemlineata), beetle beetle (Agriotes spp.), Tobacco beetle (Lasiderma serricorne), reverb worm Oyster beetle (Lyctus bruneus), Japanese beetle beetle (Anoprophora malasiaca), pine beetle (Tomicus pinipeda) and the like.
Direct insect pests: Tocusama grasshopper (Locusta migratoria), Kera (Gryllotalpa africana), Oxya yezoensis, Oyana japonica, etc.
Hymenoptera: Athalia rosae, Achillyrmex spp., Fire ant (Solenopsis spp.) And the like.
Nematodes: Rice moth nematode (Aphelenchoides besseyy), Strawberry nematode (Heterodera glycines) .
Cockroach pests: German cockroaches (Blatella germanica), Black cockroaches (Periplaneta furiginosa), American cockroaches (Periplaneta americana), Japanese cockroaches (Peripraneta brunet)
Acarina: Tetranychus urticae, Pandychus citri, Odonidus spp., Acarops pelekassi, Mite, Phyphagotaris Mite, such as Typhophagus putrescentiae, Mite, Dermatophagoides falinae, Mite, Mite censis), Tsumedani such as Minami Tsumedani (Cheyletus moorei), chicken mites, and the like.

  In addition, the preparation containing the compound of the present invention or a salt thereof is used in the field of livestock disease treatment and livestock industry, and in vertebrates such as humans, cows, sheep, goats, pigs, poultry, dogs, cats and fish. It can be used to maintain public health by combating organisms and parasites that parasitize inside and / or outside. For example, the pests include ticks (Ixodes spp. (E.g., Ixodes scapularis), bovine ticks (Boophilus spp. (E.g., Boophilus microplus), larvae ticks (Amblyomma splo. ), Rhipicephalus spp. (Eg, Rhipicephus sanguisus tick (Haemphysalis sp.), (Eg, Haemaphysalis sp. p. (eg, Ornithodoros moubata), duck (Dermahyssus gallinae), ornithonyss sylviarum, mites (Sarcoptes spp.) spp.), Acne mites (Demodex spp.), Tsutsugamushi (Eurombicula spp.), Aedes spp. For example, Aedes albopictus, Anopheles spp. C, Anopheles spp. (Culico des spp), houseflies (Musca spp.), cow flies (Hypoderma spp.), horseflies (Gasterophilus spp.), flies (Haematobia spp), cattle fly (Tabanum spp. Triatoma spp., Lice (Phthiraptera (eg, Damalinia spp., Linognathus spp., Haematopinus spp)), fleas (Ctenocephalides spp. For example) Reptiles (for example, Hair-like nematodes (for example Nippostrongylus brasiliensis, Trichostrongylus axei, Trichostrongylus colubriformis), trichinosis (such Trichinella spiralis), Haemonchus (Haemonchus contortus), Nematojirusu (such Nematodirus battus), Osuterutagu stomach worm (Ostertagia circumcincta), Couperias (Cooperia spp. ), Hymenolepis nana] and the like.

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．７１（１Ｈ，ｓ），７．６７（１Ｈ，ｄ，Ｊ＝２．４Ｈｚ），７．４９（２Ｈ，ｄ，Ｊ＝９．０Ｈｚ），７．３７（２Ｈ，ｄ，Ｊ＝８．８Ｈｚ），５．８６（１Ｈ，ｄ，Ｊ＝２．４Ｈｚ），５．４５（２Ｈ，ｓ），３．６０（３Ｈ，ｓ），１．７４（９Ｈ，ｓ）．Next, the present invention will be described more specifically with reference to Examples such as Production Examples, Formulation Examples, and Test Examples. However, the present invention is not limited to these examples.
First, a manufacturing example is shown.
Production Example 1
A mixture of 1.02 g of C02A, 1.01 g of 1- (4-chlorophenyl) -1H-pyrazol-3-ol described in Reference Production Example 12, 0.94 g of potassium carbonate and 15 mL of N, N-dimethylformamide at 80 ° C. Stir for 5 hours. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-tert-butyl-5-{[1- (4-chlorophenyl) -1H-pyrazol-3-yl] oxymethyl} -1H-pyrazole- 1.06 g of 4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 1) was obtained.

¹ H-NMR (CDCl ₃ ) δ: 7.71 (1H, s), 7.67 (1H, d, J = 2.4 Hz), 7.49 (2H, d, J = 9.0 Hz), 7 .37 (2H, d, J = 8.8 Hz), 5.86 (1H, d, J = 2.4 Hz), 5.45 (2H, s), 3.60 (3H, s), 1.74 (9H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：１．７０−１．７６（１５Ｈ，ｂｒ ｍ），１．８４（６Ｈ，ｄ，Ｊ＝２．７Ｈｚ），２．０３−２．０６（３Ｈ，ｍ），３．６８（３Ｈ，ｓ），５．６２（２Ｈ，ｓ），６．１７（１Ｈ，ｓ），７．７２（１Ｈ，ｓ）．Production Example 2
A mixture of 0.40 g of C02A, 0.30 g of 4- (1-adamantyl) -2,3-dihydro-2-oxothiazole described in Reference Production Example 16, 0.50 g of cesium carbonate and 15 mL of N, N-dimethylformamide was prepared. Stir at 0 ° C. for 0.5 hour. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 2-{[4- (4,5-dihydro-4-methyl-5-oxo-1H-tetrazol-1-yl) -2-tert-butylpyrazole- 0.56 g of 3-yl] methyloxy} -4- (1-adamantyl) thiazole (hereinafter referred to as the present compound 2) was obtained.

¹ H-NMR (CDCl ₃ ) δ: 1.70-1.76 (15H, br m), 1.84 (6H, d, J = 2.7 Hz), 2.03-2.06 (3H, m ), 3.68 (3H, s), 5.62 (2H, s), 6.17 (1H, s), 7.72 (1H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：１．７５（９Ｈ，ｓ），３．５６（３Ｈ，ｓ），５．７３（２Ｈ，ｓ），６．８６（１Ｈ，ｓ），７．３５（２Ｈ，ｄ，Ｊ＝８．３Ｈｚ），７．６８（２Ｈ，ｄ，Ｊ＝８．３Ｈｚ），７．７３（１Ｈ，ｓ）．Production Example 3
A mixture of 0.12 g of C02A, 0.08 g of 4- (4-chlorophenyl) -2,3-dihydro-2-oxothiazole described in Reference Production Example 16, 0.13 g of cesium carbonate and 10 mL of N, N-dimethylformamide was added. Stir at 1 ° C. for 1 hour. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 2- (4-chlorophenyl) -4-{[4- (4,5-dihydro-4-methyl-5-oxo-1H-tetrazol-1-yl). 0.08 g of 2-tert-butylpyrazol-3-yl] methyloxy} thiazole (hereinafter referred to as the present compound 3) was obtained.

¹ H-NMR (CDCl ₃ ) δ: 1.75 (9H, s), 3.56 (3H, s), 5.73 (2H, s), 6.86 (1H, s), 7.35 ( 2H, d, J = 8.3 Hz), 7.68 (2H, d, J = 8.3 Hz), 7.73 (1H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：１．７５（９Ｈ，ｓ），３．５７（３Ｈ，ｓ），５．７３（２Ｈ，ｓ），６．８８（１Ｈ，ｓ），７．５２（２Ｈ，ｄ，Ｊ＝８．５Ｈｚ），７．６３（２Ｈ，ｄ，Ｊ＝８．５Ｈｚ），７．７３（１Ｈ，ｓ）．Production Example 4
A mixture of 0.30 g of C02A, 0.24 g of 4- (4-bromophenyl) -2,3-dihydro-2-oxothiazole described in Reference Production Example 16, 0.37 g of cesium carbonate and 10 mL of N, N-dimethylformamide was prepared. Stir at 80 ° C. for 1 hour. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 2- (4-bromophenyl) -4-{[4- (4,5-dihydro-4-methyl-5-oxo-1H-tetrazol-1-yl). ) -2-tert-butylpyrazol-3-yl] methyloxy} thiazole (hereinafter referred to as the present compound 4) was obtained in an amount of 0.25 g.

¹ H-NMR (CDCl ₃ ) δ: 1.75 (9H, s), 3.57 (3H, s), 5.73 (2H, s), 6.88 (1H, s), 7.52 ( 2H, d, J = 8.5 Hz), 7.63 (2H, d, J = 8.5 Hz), 7.73 (1H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．７６−７．７０（３Ｈ，ｍ），７．０８（２Ｈ，ｔ，Ｊ＝８．６６Ｈｚ），６．８０（１Ｈ，ｓ），５．７３（２Ｈ，ｓ），３．５６（３Ｈ，ｓ），１．７５（９Ｈ，ｓ）．Production Example 5
A mixture of 0.30 g of C02A, 0.19 g of 4- (4-fluorophenyl) -2,3-dihydro-2-oxothiazole described in Reference Production Example 16, 0.37 g of cesium carbonate and 10 mL of N, N-dimethylformamide was prepared. The mixture was stirred at 80 ° C. for 1.5 hours. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 2- (4-fluorophenyl) -4-{[4- (4,5-dihydro-4-methyl-5-oxo-1H-tetrazol-1-yl). ) -2-tert-butylpyrazol-3-yl] methyloxy} thiazole (hereinafter referred to as the present compound 5) was obtained in an amount of 0.20 g.

¹ H-NMR (CDCl ₃ ) δ: 7.76-7.70 (3H, m), 7.08 (2H, t, J = 8.66 Hz), 6.80 (1H, s), 5.73 (2H, s), 3.56 (3H, s), 1.75 (9H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：８．７７（１Ｈ，ｄｄ，Ｊ＝４．９，１．５Ｈｚ），７．８５（１Ｈ，ｄｄ，Ｊ＝８．０，１．５Ｈｚ），７．６３（１Ｈ，ｄ，Ｊ＝２．７Ｈｚ），７．４７−７．４３（３Ｈ，ｍ），７．３７−７．３３（２Ｈ，ｍ），５．８６（１Ｈ，ｄ，Ｊ＝２．７Ｈｚ），５．５５（２Ｈ，ｓ），３．６６（３Ｈ，ｓ）．Production Example 6
A mixture of 0.45 g of C05A, 0.29 g of 1- (4-chlorophenyl) -1H-pyrazol-3-ol described in Reference Production Example 12, 0.41 g of potassium carbonate and 10 mL of acetonitrile was stirred with heating under reflux for 4 hours. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (2-{[1- (4-chlorophenyl) -1H-pyrazol-3-yl] oxymethyl} -pyridin-3-yl) -4-methyl. 0.56 g of -1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 6) was obtained.

¹ H-NMR (CDCl ₃ ) δ: 8.77 (1H, dd, J = 4.9, 1.5 Hz), 7.85 (1H, dd, J = 8.0, 1.5 Hz), 7. 63 (1H, d, J = 2.7 Hz), 7.47-7.43 (3H, m), 7.37-7.33 (2H, m), 5.86 (1H, d, J = 2) .7 Hz), 5.55 (2H, s), 3.66 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：３．６８（３Ｈ，ｓ），５．５７（２Ｈ，ｓ），５．９１（１Ｈ，ｄ，Ｊ＝２．７Ｈｚ），７．３０（１Ｈ，ｄ，Ｊ＝５．３Ｈｚ），７．４２−７．３５（３Ｈ，ｍ），７．５２（２Ｈ，ｄｄ，Ｊ＝６．８，２．２Ｈｚ），７．６８（１Ｈ，ｄ，Ｊ＝２．７Ｈｚ）．Production Example 7
A mixture of 0.27 g of C07A, 0.14 g of 1- (4-chlorophenyl) -1H-pyrazol-3-ol described in Reference Production Example 12, 0.20 g of potassium carbonate, and 10 mL of acetonitrile was stirred for 2 hours while heating under reflux. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (2-{[1- (4-chlorophenyl) -1H-pyrazol-3-yl] oxymethyl} -3-thienyl) -4-methyl-1. , 4-Dihydrotetrazol-5-one (hereinafter referred to as the present compound 7) was obtained in an amount of 0.17 g.

¹ H-NMR (CDCl ₃ ) δ: 3.68 (3H, s), 5.57 (2H, s), 5.91 (1H, d, J = 2.7 Hz), 7.30 (1H, d , J = 5.3 Hz), 7.42-7.35 (3H, m), 7.52 (2H, dd, J = 6.8, 2.2 Hz), 7.68 (1H, d, J = 2.7 Hz).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：３．６８（３Ｈ，ｓ），５．８１（２Ｈ，ｓ），６．８７（１Ｈ，ｓ），７．３４（１Ｈ，ｄ，Ｊ＝５．５Ｈｚ），７．３６（２Ｈ，ｄｄ，Ｊ＝６．６，１．８Ｈｚ），７．４４（１Ｈ，ｄ，Ｊ＝５．５Ｈｚ），７．７４（２Ｈ，ｄｄ，Ｊ＝６．６，１．８Ｈｚ）．Production Example 8
C07A A mixture of 0.25 g of C07A, 0.19 g of 4- (4-chlorophenyl) -2,3-dihydro-2-oxothiazole described in Reference Production Example 16, 0.36 g of cesium carbonate and 10 mL of N, N-dimethylformamide The mixture was stirred at 80 ° C. for 1.5 hours. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 2- (4-chlorophenyl) -4-{[4- (4,5-dihydro-4-methyl-5-oxo-1H-tetrazol-1-yl). 0.17 g of -3-thienyl] methyloxy} thiazole (hereinafter referred to as the present compound 8) was obtained.

¹ H-NMR (CDCl ₃ ) δ: 3.68 (3H, s), 5.81 (2H, s), 6.87 (1H, s), 7.34 (1H, d, J = 5.5 Hz) ), 7.36 (2H, dd, J = 6.6, 1.8 Hz), 7.44 (1H, d, J = 5.5 Hz), 7.74 (2H, dd, J = 6.6) 1.8 Hz).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：３．６５（３Ｈ，ｓ），５．１８（２Ｈ，ｓ），５．９７（１Ｈ，ｓ），７．０３（２Ｈ，ｄ，Ｊ＝８．５Ｈｚ），７．１２（１Ｈ，ｄ，Ｊ＝５．５Ｈｚ），７．２９（１Ｈ，ｄ，Ｊ＝５．５Ｈｚ），７．４６（２Ｈ，ｄ，Ｊ＝８．５Ｈｚ）．Production Example 9
A mixture of 0.20 g of C07A, 0.19 g of 4- (4-bromophenyl) -2,3-dihydro-2-oxothiazole described in Reference Production Example 16, 0.28 g of cesium carbonate and 10 mL of N, N-dimethylformamide. The mixture was stirred at 80 ° C. for 1.5 hours. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 2- (4-bromophenyl) -4-{[4- (4,5-dihydro-4-methyl-5-oxo-1H-tetrazol-1-yl). 0.05 g of) -3-thienyl] methyloxy} thiazole (hereinafter referred to as the present compound 9) was obtained.

¹ H-NMR (CDCl ₃ ) δ: 3.65 (3H, s), 5.18 (2H, s), 5.97 (1H, s), 7.03 (2H, d, J = 8.5 Hz) ), 7.12 (1H, d, J = 5.5 Hz), 7.29 (1H, d, J = 5.5 Hz), 7.46 (2H, d, J = 8.5 Hz).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．８７（１Ｈ，ｓ），７．６６（１Ｈ，ｄ，Ｊ＝２．５Ｈｚ），７．５２（２Ｈ，ｄｔ，Ｊ＝９．５，２．６Ｈｚ），７．３６（２Ｈ，ｄｔ，Ｊ＝９．５，２．６Ｈｚ），５．９１（１Ｈ，ｄ，Ｊ＝２．５Ｈｚ），５．４６（２Ｈ，ｓ），３．９７（３Ｈ，ｓ），３．６２（３Ｈ，ｓ）．Production Example 10
A mixture of 0.25 g of C09A, 0.18 g of 1- (4-chlorophenyl) -1H-pyrazol-3-ol described in Reference Production Example 12, 0.15 g of potassium carbonate and 10 mL of acetonitrile was stirred with heating under reflux for 5 hours. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography, and 1- (1-methyl-3-{[1- (4-chlorophenyl) -1H-pyrazol-3-yl] oxymethyl} -1H-pyrazole-4- Yl) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 10) 0.21 g was obtained.

¹ H-NMR (CDCl ₃ ) δ: 7.87 (1H, s), 7.66 (1H, d, J = 2.5 Hz), 7.52 (2H, dt, J = 9.5, 2. 6 Hz), 7.36 (2H, dt, J = 9.5, 2.6 Hz), 5.91 (1H, d, J = 2.5 Hz), 5.46 (2H, s), 3.97 ( 3H, s), 3.62 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．７７（１Ｈ，ｓ），７．６７（１Ｈ，ｄ，Ｊ＝２．５Ｈｚ），７．４６（２Ｈ，ｄｔ，Ｊ＝９．４，２．５Ｈｚ），７．３７（２Ｈ，ｄｔ，Ｊ＝９．５，２．５Ｈｚ），５．８８（１Ｈ，ｄ，Ｊ＝２．５Ｈｚ），５．４６（２Ｈ，ｓ），４．０３（３Ｈ，ｓ），３．６４（３Ｈ，ｓ）．Production Example 11
A mixture of 0.31 g of C11A, 0.21 g of 1- (4-chlorophenyl) -1H-pyrazol-3-ol described in Reference Production Example 12, 0.18 g of potassium carbonate and 10 mL of acetonitrile was stirred with heating under reflux for 5 hours. Water was poured into the reaction mixture allowed to cool, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-methyl-5-{[1- (4-chlorophenyl) -1H-pyrazol-3-yl] oxymethyl} -1H-pyrazole-4- Yl) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 11) was obtained in an amount of 0.30 g.

¹ H-NMR (CDCl ₃ ) δ: 7.77 (1H, s), 7.67 (1H, d, J = 2.5 Hz), 7.46 (2H, dt, J = 9.4, 2. 5 Hz), 7.37 (2H, dt, J = 9.5, 2.5 Hz), 5.88 (1H, d, J = 2.5 Hz), 5.46 (2H, s), 4.03 ( 3H, s), 3.64 (3H, s).

１Ｈ−ＮＭＲ（ＣＤＣｌ３）δ：７．９０（１Ｈ，ｄ，Ｊ＝２．１Ｈｚ），７．７１（１Ｈ，ｓ），７．６６（１Ｈ，ｄｄ，Ｊ＝７．９，１．７Ｈｚ），７．２３（１Ｈ，ｔｄ，Ｊ＝７．８，１．７Ｈｚ），７．０５−７．０３（２Ｈ，ｍ），５．８０（１Ｈ，ｄ，Ｊ＝２．１Ｈｚ），５．４４（２Ｈ，ｓ），３．８９（３Ｈ，ｓ），３．５８（３Ｈ，ｓ），１．７５（９Ｈ，ｓ）．Production Example 12
A mixture of 0.50 g of C02A, 0.36 g of 1- (2-methoxyphenyl) -1H-pyrazol-3-ol described in Reference Production Example 14, 0.26 g of potassium carbonate, and 26 mL of acetonitrile was stirred at 60 ° C. for 1 hour. . Saturated multistory water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated multilayer water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-tert-butyl-5-{[1- (2-methoxyphenyl) -1H-pyrazol-3-yl] oxymethyl} -1H-pyrazole. 0.17 g of -4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 12) was obtained.

1H-NMR (CDCl3) δ: 7.90 (1H, d, J = 2.1 Hz), 7.71 (1H, s), 7.66 (1H, dd, J = 7.9, 1.7 Hz) , 7.23 (1H, td, J = 7.8, 1.7 Hz), 7.05-7.03 (2H, m), 5.80 (1H, d, J = 2.1 Hz), 5. 44 (2H, s), 3.89 (3H, s), 3.58 (3H, s), 1.75 (9H, s).

１Ｈ−ＮＭＲ（ＣＤＣｌ３）δ：７．８７（１Ｈ，ｄ，Ｊ＝２．５Ｈｚ），７．７６（１Ｈ，ｓ），７．５９（１Ｈ，ｄｄ，Ｊ＝７．８，１．７Ｈｚ），７．２３（１Ｈ，ｄｄｄ，Ｊ＝８．８，７．０，１．２Ｈｚ），７．０６−７．００（２Ｈ，ｍ），５．８１（１Ｈ，ｄ，Ｊ＝２．７Ｈｚ），５．４５（２Ｈ，ｓ），４．０３（３Ｈ，ｓ），３．８８（３Ｈ，ｓ），３．６１（３Ｈ，ｓ）．Production Example 13
A mixture of 0.31 g of C11A, 0.25 g of 1- (2-methoxyphenyl) -1H-pyrazol-3-ol described in Reference Production Example 14, 0.18 g of potassium carbonate, and 18 mL of acetonitrile was stirred at 60 ° C. for 1 hour. . Saturated multistory water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated multilayer water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-methyl-5-{[1- (2-methoxyphenyl) -1H-pyrazol-3-yl] oxymethyl} -1H-pyrazole-4. -Il) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 13) 0.13 g was obtained.

1H-NMR (CDCl3) δ: 7.87 (1H, d, J = 2.5 Hz), 7.76 (1H, s), 7.59 (1H, dd, J = 7.8, 1.7 Hz) , 7.23 (1H, ddd, J = 8.8, 7.0, 1.2 Hz), 7.06-7.00 (2H, m), 5.81 (1H, d, J = 2.7 Hz) ), 5.45 (2H, s), 4.03 (3H, s), 3.88 (3H, s), 3.61 (3H, s).

１Ｈ−ＮＭＲ（ＣＤＣｌ３）δ：７．７４（１Ｈ，ｓ），７．４４（１Ｈ，ｓ），７．３９（１Ｈ，ｄ，Ｊ＝８．２Ｈｚ），６．８８（１Ｈ，ｄ，Ｊ＝８．５Ｈｚ），５．１６（２Ｈ，ｓ），３．８６（３Ｈ，ｓ），３．６５（３Ｈ，ｓ），２．１８（３Ｈ，ｓ），２．１５（３Ｈ，ｓ），１．７４（９Ｈ，ｓ）．Production Example 14
C02A 0.50 g, 4- (5-chloro-1,4-dimethyl-1H-pyrazol-3-yl) -2-methyl-phenol 0.38 g described in Reference Production Example 21, potassium carbonate 0.26 g, N, A mixture of 26 mL of N-dimethylformamide was stirred at 60 ° C. for 1 hour. Saturated multistory water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated multilayer water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-tert-butyl-5- [2-methyl-4- (5-chloro-1,4-dimethyl-1H-pyrazol-3-yl). -Phenoxymethyl] -1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 14) 0.25 g was obtained.

1H-NMR (CDCl3) δ: 7.74 (1H, s), 7.44 (1H, s), 7.39 (1H, d, J = 8.2 Hz), 6.88 (1H, d, J = 8.5 Hz), 5.16 (2H, s), 3.86 (3H, s), 3.65 (3H, s), 2.18 (3H, s), 2.15 (3H, s) , 1.74 (9H, s).

１Ｈ−ＮＭＲ（ＣＤＣｌ３）δ：７．８０（１Ｈ，ｓ），７．４５（１Ｈ，ｓ），７．４０（１Ｈ，ｄｄ，Ｊ＝８．５，２．１Ｈｚ），６．９２（１Ｈ，ｄ，Ｊ＝８．５Ｈｚ），５．２０（２Ｈ，ｓ），４．０２（３Ｈ，ｓ），３．８６（３Ｈ，ｓ），３．６９（３Ｈ，ｓ），２．２１（３Ｈ，ｓ），２．１５（３Ｈ，ｓ）．Production Example 15
0.31 g of C11A, 0.26 g of 4- (5-chloro-1,4-dimethyl-1H-pyrazol-3-yl) -2-methyl-phenol described in Reference Production Example 22, 0.18 g of potassium carbonate, N , N-dimethylformamide 18 mL was stirred at 60 ° C. for 1 hour. Saturated multistory water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated multilayer water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-methyl-5- [2-methyl-4- (5-chloro-1,4-dimethyl-1H-pyrazol-3-yl) -phenoxy. 0.39 g of methyl] -1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 15) was obtained.

1H-NMR (CDCl3) δ: 7.80 (1H, s), 7.45 (1H, s), 7.40 (1H, dd, J = 8.5, 2.1 Hz), 6.92 (1H , D, J = 8.5 Hz), 5.20 (2H, s), 4.02 (3H, s), 3.86 (3H, s), 3.69 (3H, s), 2.21 ( 3H, s), 2.15 (3H, s).

１Ｈ−ＮＭＲ（ＣＤＣｌ３）δ：８．７５（１Ｈ，ｄｄ，Ｊ＝４．８，１．６Ｈｚ），７．８７（１Ｈ，ｄｄ，Ｊ＝８．０，１．６Ｈｚ），７．４９（１Ｈ，ｄｄ，Ｊ＝８．０，４．８Ｈｚ），７．３８（１Ｈ，ｄ，Ｊ＝１．４Ｈｚ），７．３３（１Ｈ，ｄｄ，Ｊ＝８．５，１．８Ｈｚ），６．８８（１Ｈ，ｄ，Ｊ＝８．５Ｈｚ），５．４６（２Ｈ，ｓ），３．８４（３Ｈ，ｓ），３．６２（３Ｈ，ｓ），２．１３（３Ｈ，ｓ），２．０２（３Ｈ，ｓ）．Production Example 16
0.45 g of C05A, 0.41 g of 4- (5-chloro-1,4-dimethyl-1H-pyrazol-3-yl) -2-methyl-phenol described in Reference Production Example 22, 0.29 g of potassium carbonate, N , N-dimethylformamide 28 mL was stirred at 60 ° C. for 1 hour. Saturated multistory water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated multilayer water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (2- [2-methyl-4- (5-chloro-1,4-dimethyl-1H-pyrazol-3-yl) -phenoxymethyl] -pyridine. -3-g) -4-methyl-1,4-dihydrotetrazol-5-one (hereinafter referred to as the present compound 16) 0.25 g was obtained.

1H-NMR (CDCl3) δ: 8.75 (1H, dd, J = 4.8, 1.6 Hz), 7.87 (1H, dd, J = 8.0, 1.6 Hz), 7.49 ( 1H, dd, J = 8.0, 4.8 Hz), 7.38 (1H, d, J = 1.4 Hz), 7.33 (1H, dd, J = 8.5, 1.8 Hz), 6 .88 (1H, d, J = 8.5 Hz), 5.46 (2H, s), 3.84 (3H, s), 3.62 (3H, s), 2.13 (3H, s), 2.02 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．５８（１Ｈ，ｓ），３．７０（３Ｈ，ｓ），２．４０（３Ｈ，ｓ），１．６８（９Ｈ，ｓ）．Reference production example 1
A mixture of 9.50 g of 1-tert-butyl-5-methyl-1H-pyrazole-4-carboxylic acid, 7.28 g of oxalyl dichloride, about 75 mg of N, N-dimethylformamide and 200 mL of tetrahydrofuran was stirred at 25 ° C. for 1 hour. . The reaction mixture was concentrated under reduced pressure to obtain 1-tert-butyl-5-methyl-1H-pyrazole-4-carboxylic acid chloride.
A mixture of 13.90 g of aluminum chloride, 20.34 g of sodium azide and 100 mL of tetrahydrofuran was stirred with heating under reflux for 2 hours. After the reaction mixture was ice-cooled, a mixture of 1-tert-butyl-5-methyl-1H-pyrazole-4-carboxylic acid chloride and 100 mL of tetrahydrofuran was added to the reaction mixture, and the mixture was stirred for 3 days with heating under reflux. After cooling, the reaction mixture was added to a mixture of 31.29 g sodium nitrite and 100 mL water with stirring. The mixture was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure, and then 1- (1-tert-butyl-5-methyl-1H-pyrazol-4-yl) -1,4-dihydrotetrazol-5-one 13 .40 g was obtained.
1- (1-tert-butyl-5-methyl-1H-pyrazol-4-yl) -1,4-dihydrotetrazol-5-one, potassium carbonate 23.78 g, dimethyl sulfate 7.89 g and N, N-dimethyl A mixture of 100 mL formamide was stirred at 25 ° C. for 1 hour. Saturated aqueous sodium hydrogen carbonate was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate and dried over anhydrous sodium sulfate. Concentration under reduced pressure gave 8.85 g of 1- (1-tert-butyl-5-methyl-1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (denoted as C01A). Got.

¹ H-NMR (CDCl ₃ ) δ: 7.58 (1H, s), 3.70 (3H, s), 2.40 (3H, s), 1.68 (9H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．７３（１Ｈ，ｓ），４．８１（２Ｈ，ｓ），３．７２（３Ｈ，ｓ），１．７５（９Ｈ，ｓ）．Reference production example 2
A mixture of 1.00 g of C01A, 0.41 g of 1,1′-azobis (cyclohexane-1-carbonitrile), 0.87 g of N-bromosuccinimide and 30 mL of chlorobenzene was stirred with heating under reflux for 3 hours. After cooling, water was poured into the reaction solution and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-tert-butyl-5-bromomethyl-1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one ( 1.10 g was obtained.

¹ H-NMR (CDCl ₃ ) δ: 7.73 (1H, s), 4.81 (2H, s), 3.72 (3H, s), 1.75 (9H, s).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−Ｄ_６）δ：８．６５（１Ｈ，ｄｄ，Ｊ＝４．８，１．４Ｈｚ），７．９５（１Ｈ，ｄｄ，Ｊ＝８．０，１．７Ｈｚ），７．５０（１Ｈ，ｄｄ，Ｊ＝８．０，４．８Ｈｚ），２．４４（３Ｈ，ｓ）．Reference production example 3
A mixture of 5.00 g of 2-methylpyridine-3-carboxylic acid, 3.42 g of oxalyl dichloride, about 75 mg of N, N-dimethylformamide and 200 mL of tetrahydrofuran was stirred at 25 ° C. for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 2-methylpyridine-3-carboxylic acid chloride.
A mixture of 6.53 g of aluminum chloride, 9.55 g of sodium azide and 100 mL of tetrahydrofuran was stirred with heating under reflux for 2 hours. After the reaction mixture was ice-cooled, a mixture of 2-methylpyridine-3-carboxylic acid chloride and 100 mL of tetrahydrofuran was added to the reaction mixture, and the mixture was stirred for 2 days with heating under reflux. After cooling, the reaction mixture was added with stirring to a mixture of sodium nitrite 14.07 g and water 100 mL. The mixture was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 3.00 g of 1- (2-methylpyridin-3-yl) -1,4-dihydrotetrazol-5-one (denoted as C03A). It was.

¹ H-NMR (DMSO-D ₆ ) δ: 8.65 (1H, dd, J = 4.8, 1.4 Hz), 7.95 (1H, dd, J = 8.0, 1.7 Hz), 7.50 (1H, dd, J = 8.0, 4.8 Hz), 2.44 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：８．６４（１Ｈ，ｄｄ，Ｊ＝４．９，１．６Ｈｚ），７．７１（１Ｈ，ｄｄ，Ｊ＝８．０，１．６Ｈｚ），７．３２（１Ｈ，ｄｄ，Ｊ＝８．０，４．９Ｈｚ），３．７４（３Ｈ，ｓ），２．５６（３Ｈ，ｓ）．Reference production example 4
A mixture of 0.50 g of C03A, 1.29 g of potassium carbonate, 0.43 g of dimethyl sulfate and 15 mL of N, N-dimethylformamide was stirred at 25 ° C. for 1 hour. Saturated aqueous sodium hydrogen carbonate was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was subjected to silica gel column chromatography to give 0.27 g of 1- (2-methylpyridin-3-yl) -4-methyl-1,4-dihydrotetrazol-5-one (denoted as C04A). Obtained.

¹ H-NMR (CDCl ₃ ) δ: 8.64 (1H, dd, J = 4.9, 1.6 Hz), 7.71 (1H, dd, J = 8.0, 1.6 Hz), 7. 32 (1H, dd, J = 8.0, 4.9 Hz), 3.74 (3H, s), 2.56 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：８．６９（１Ｈ，ｄｄ，Ｊ＝４．８，１．５Ｈｚ），７．８５（１Ｈ，ｄｄ，Ｊ＝８．１，１．５Ｈｚ），７．４６（１Ｈ，ｄｄ，Ｊ＝８．１，４．８Ｈｚ），４．７５（２Ｈ，ｓ），３．７６（３Ｈ，ｓ）．Reference production example 5
A mixture of 1.00 g of C04A, 0.51 g of 1,1′-azobis (cyclohexane-1-carbonitrile), 1.07 g of N-bromosuccinimide and 10 mL of chlorobenzene was stirred with heating under reflux for 5 hours. After cooling, water was poured into the reaction solution and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to obtain 0.23 g of 1- (2-bromomethyl-pyridin-3-yl) -4-methyl-1,4-dihydrotetrazol-5-one (referred to as C05A). Obtained.

¹ H-NMR (CDCl ₃ ) δ: 8.69 (1H, dd, J = 4.8, 1.5 Hz), 7.85 (1H, dd, J = 8.1, 1.5 Hz), 7. 46 (1H, dd, J = 8.1, 4.8 Hz), 4.75 (2H, s), 3.76 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：２．４７（３Ｈ，ｓ），３．７１（３Ｈ，ｓ），７．１３（１Ｈ，ｄ，Ｊ＝５．５Ｈｚ），７．１７（１Ｈ，ｄ，Ｊ＝５．５Ｈｚ）．Reference production example 6
A mixture of 3.70 g of 2-methyl-3-thienylcarboxylic acid, 3.63 g of oxalyl dichloride, about 15 mg of N, N-dimethylformamide and 50 mL of tetrahydrofuran was stirred at 25 ° C. for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 2-methyl-3-thienylcarboxylic acid chloride.
A mixture of 10.15 g of aluminum chloride, 4.18 g of sodium azide and 20 mL of tetrahydrofuran was stirred with heating under reflux for 2 hours. After cooling the reaction mixture with ice, a mixture of 2-methyl-3-thienylcarboxylic acid chloride and 20 mL of tetrahydrofuran was added to the reaction mixture, and the mixture was stirred for 10 hours under heating to reflux. After cooling, the reaction mixture was added to a mixture of 15.62 g sodium nitrite and 20 mL water with stirring. The mixture was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1- (2-methyl-3-thienyl) -1,4-dihydrotetrazol-5-one.
A mixture of the total amount of 1- (2-methyl-3-thienyl) -1,4-dihydrotetrazol-5-one, 11.87 g of potassium carbonate, 3.94 g of dimethyl sulfate and 20 mL of N, N-dimethylformamide at 25 ° C. Stir for 1 hour. Saturated aqueous sodium hydrogen carbonate was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was subjected to silica gel column chromatography to obtain 2.64 g of 1- (2-methyl-3-thienyl) -4-methyl-1,4-dihydrotetrazol-5-one (referred to as C06A). Got.

¹ H-NMR (CDCl ₃ ) δ: 2.47 (3H, s), 3.71 (3H, s), 7.13 (1H, d, J = 5.5 Hz), 7.17 (1H, d , J = 5.5 Hz).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：３．７２（３Ｈ，ｓ），４．８６（２Ｈ，ｓ），７．３２（１Ｈ，ｄ，Ｊ＝５．６Ｈｚ），７．４０（１Ｈ，ｄ，Ｊ＝５．６Ｈｚ）．Reference production example 7
A mixture of 0.36 g of C06A, 0.15 g of 1,1′-azobis (cyclohexane-1-carbonitrile), 0.31 g of N-bromosuccinimide and 5 mL of chlorobenzene was stirred with heating under reflux for 5 hours. After cooling, water was poured into the reaction solution and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to obtain 0.23 g of 1- (2-bromomethyl-3-thienyl) -4-methyl-1,4-dihydrotetrazol-5-one (denoted as C07A). .

¹ H-NMR (CDCl ₃ ) δ: 3.72 (3H, s), 4.86 (2H, s), 7.32 (1H, d, J = 5.6 Hz), 7.40 (1H, d , J = 5.6 Hz).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−Ｄ_６）δ：８．０７（１Ｈ，ｓ），３．８２（３Ｈ，ｓ），２．１３（３Ｈ，ｓ）．
１−（１，３−ジメチル−１Ｈ−ピラゾール−４−イル）−１，４−ジヒドロテトラゾール−５−オン、炭酸カリウム３．２５ｇ、ジメチル硫酸１．０８ｇおよびＮ，Ｎ−ジメチルホルムアミド１００ｍＬの混合物を６０℃で１時間攪拌した。反応混合物に飽和重曹水を注加し、酢酸エチルで抽出した。有機層を飽和重曹水で洗浄し、無水硫酸ナトリウムで乾燥した。減圧下に濃縮後し、１−（１，３−ジメチル−１Ｈ−ピラゾール−４−イル）−４−メチル−１，４−ジヒドロテトラゾール−５−オン（Ｃ０８Ａと記す）０．５０ｇを得た。

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．７３（１Ｈ，ｓ），３．８８（３Ｈ，ｓ），３．７０（３Ｈ，ｓ），２．３３（３Ｈ，ｓ）．Reference production example 8
A mixture of 1.30 g of 1,3-dimethyl-1H-pyrazole-4-carboxylic acid, 1.00 g of oxalyl dichloride, about 15 mg of N, N-dimethylformamide and 50 mL of tetrahydrofuran was stirred at 25 ° C. for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 1,3-dimethyl-1H-pyrazole-4-carboxylic acid chloride.
A mixture of 1.90 g of aluminum chloride, 2.78 g of sodium azide and 50 mL of tetrahydrofuran was stirred with heating under reflux for 2 hours. The reaction mixture was ice-cooled, a mixture of 1,3-dimethyl-1H-pyrazole-4-carboxylic acid chloride and tetrahydrofuran (50 mL) was added, and the mixture was stirred with heating under reflux for 3 days. After cooling, the reaction mixture was added to a mixture of 4.28 g sodium nitrite and 100 mL water with stirring. The mixture was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 0.7 g of 1- (1,3-dimethyl-1H-pyrazol-4-yl) -1,4-dihydrotetrazol-5-one. It was.

¹ H-NMR (DMSO-D ₆ ) δ: 8.07 (1H, s), 3.82 (3H, s), 2.13 (3H, s).
Mixture of 1- (1,3-dimethyl-1H-pyrazol-4-yl) -1,4-dihydrotetrazol-5-one, 3.25 g of potassium carbonate, 1.08 g of dimethyl sulfate and 100 mL of N, N-dimethylformamide Was stirred at 60 ° C. for 1 hour. Saturated aqueous sodium hydrogen carbonate was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate and dried over anhydrous sodium sulfate. After concentration under reduced pressure, 0.50 g of 1- (1,3-dimethyl-1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (denoted as C08A) was obtained. .

¹ H-NMR (CDCl ₃ ) δ: 7.73 (1H, s), 3.88 (3H, s), 3.70 (3H, s), 2.33 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．８９（１Ｈ，ｓ），４．６９（２Ｈ，ｓ），３．９４（３Ｈ，ｓ），３．７２（３Ｈ，ｓ）．Reference production example 9
A mixture of 0.58 g of C08A, 0.25 g of 1,1′-azobis (cyclohexane-1-carbonitrile), 0.53 g of N-bromosuccinimide and 30 mL of chlorobenzene was stirred with heating under reflux for 3 hours. After cooling, water was poured into the reaction solution and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography, and 1- (1-methyl-3-bromomethyl-1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (C09A and 0.25 g was obtained.

¹ H-NMR (CDCl ₃ ) δ: 7.89 (1H, s), 4.69 (2H, s), 3.94 (3H, s), 3.72 (3H, s).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−Ｄ_６）δ：７．６２（１Ｈ，ｓ），３．８０（３Ｈ，ｓ），２．２２（３Ｈ，ｓ）．
１−（１，５−ジメチル−１Ｈ−ピラゾール−４−イル）−１，４−ジヒドロテトラゾール−５−オン、炭酸カリウム４．００ｇ、ジメチル硫酸１．３３ｇおよびＮ，Ｎ−ジメチルホルムアミド１００ｍＬの混合物を６０℃で１時間攪拌した。反応混合物に飽和重曹水を注加し、酢酸エチルで抽出した。有機層を飽和重曹水で洗浄し、無水硫酸ナトリウムで乾燥した。減圧下に濃縮後し、１−（１，５−ジメチル−１Ｈ−ピラゾール−４−イル）−４−メチル−１，４−ジヒドロテトラゾール−５−オン（Ｃ１０Ａと記す）１．４０ｇを得た。

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．６５（１Ｈ，ｓ），３．８４（３Ｈ，ｓ），３．７０（３Ｈ，ｓ），２．３１（３Ｈ，ｓ）．Reference production example 10
A mixture of 1.60 g of 1,5-dimethyl-1H-pyrazole-4-carboxylic acid, 1.23 g of oxalyl dichloride, about 15 mg of N, N-dimethylformamide and 50 mL of tetrahydrofuran was stirred at 25 ° C. for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 1,5-dimethyl-1H-pyrazole-4-carboxylic acid chloride.
A mixture of aluminum chloride (2.34 g), sodium azide (3.42 g) and tetrahydrofuran (50 mL) was stirred with heating under reflux for 2 hours. The reaction mixture was ice-cooled, a mixture of 1,5-dimethyl-1H-pyrazole-4-carboxylic acid chloride and 50 mL of tetrahydrofuran was added to the reaction mixture, and the mixture was stirred for 3 days with heating under reflux. After cooling, the reaction mixture was added to a mixture of sodium nitrite 5.27 g and water 100 mL with stirring. The mixture was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 1.6 g of 1- (1,5-dimethyl-1H-pyrazol-4-yl) -1,4-dihydrotetrazol-5-one. It was.

¹ H-NMR (DMSO-D ₆ ) δ: 7.62 (1H, s), 3.80 (3H, s), 2.22 (3H, s).
A mixture of 1- (1,5-dimethyl-1H-pyrazol-4-yl) -1,4-dihydrotetrazol-5-one, 4.00 g of potassium carbonate, 1.33 g of dimethyl sulfate and 100 mL of N, N-dimethylformamide. Was stirred at 60 ° C. for 1 hour. Saturated aqueous sodium hydrogen carbonate was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate and dried over anhydrous sodium sulfate. After concentration under reduced pressure, 1.40 g of 1- (1,5-dimethyl-1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (referred to as C10A) was obtained. .

¹ H-NMR (CDCl ₃ ) δ: 7.65 (1H, s), 3.84 (3H, s), 3.70 (3H, s), 2.31 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．８１（１Ｈ，ｓ），４．６６（２Ｈ，ｓ），３．９７（３Ｈ，ｓ），３．７１（３Ｈ，ｓ）．Reference production example 11
A mixture of 1.40 g of C10A, 0.71 g of 1,1′-azobis (cyclohexane-1-carbonitrile), 1.48 g of N-bromosuccinimide and 90 mL of chlorobenzene was stirred with heating under reflux for 3 hours. After cooling, water was poured into the reaction solution and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 1- (1-methyl-5-bromomethyl-1H-pyrazol-4-yl) -4-methyl-1,4-dihydrotetrazol-5-one (with C11A). 1.20 g was obtained.

¹ H-NMR (CDCl ₃ ) δ: 7.81 (1H, s), 4.66 (2H, s), 3.97 (3H, s), 3.71 (3H, s).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−ｄ_６）δ（ｐｐｍ）：５．８４（１Ｈ，ｄ，Ｊ＝２．４Ｈｚ），７．４８（２Ｈ，ｄ，Ｊ＝８．９Ｈｚ），７．７０（２Ｈ，ｄ，Ｊ＝８．９Ｈｚ），８．２５（１Ｈ，ｄ，Ｊ＝２．７Ｈｚ），１０．３２（１Ｈ，ｓ）．Reference production example 12
To a mixture of 28.5 g of 4-chlorophenylhydrazine, 81.3 g of 28% sodium methoxide-methanol solution and 200 mL of methanol, 29.4 g of methyl propiolate was added under ice cooling, and the mixture was stirred at 100 ° C. for 2 hours. To the reaction mixture allowed to cool, 100 mL of ice water was added, acidified with 30% sulfuric acid, and then stirred at 100 ° C. for 2 hours. To the reaction mixture allowed to cool, saturated brine was poured, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 15.6 g of 1- (4-chlorophenyl) -1H-pyrazol-3-ol.
1- (4-Chlorophenyl) -1H-pyrazol-3-ol

¹ H-NMR (DMSO-d ₆ ) δ (ppm): 5.84 (1H, d, J = 2.4 Hz), 7.48 (2H, d, J = 8.9 Hz), 7.70 (2H , D, J = 8.9 Hz), 8.25 (1H, d, J = 2.7 Hz), 10.32 (1H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ（ｐｐｍ）：７．８４（１Ｈ，ｄ，Ｊ＝１２．７Ｈｚ），５．３８（１Ｈ，ｄ，Ｊ＝１２．４Ｈｚ），３．８０（３Ｈ，ｓ），２．８４（４Ｈ，ｓ）．Reference production example 13
200 g of N-hydroxysuccinimide, 287 g of sodium 3-methoxyacrylate described in Reference Production Example 30, 528 g of 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride, 269 g of pyridine and N, N-dimethylformamide 2 L of the mixture was stirred at room temperature for 44 hours. The reaction mixture was added to aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate, aqueous sodium hydrogen sulfate solution and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was washed with a mixed solvent of tert-butyl methyl ether and hexane and then dried under reduced pressure to obtain 174 g of succinimide 3-methoxyacrylate.
Succinimide 3-methoxyacrylate

¹ H-NMR (CDCl ₃ ) δ (ppm): 7.84 (1H, d, J = 12.7 Hz), 5.38 (1H, d, J = 12.4 Hz), 3.80 (3H, s ), 2.84 (4H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ（ｐｐｍ）：７．７３（１Ｈ，ｄ，Ｊ＝２．７Ｈｚ），７．５０（１Ｈ，ｄｄ，Ｊ＝８．０，１．６Ｈｚ），７．２６（１Ｈ，ｄｄｄ，Ｊ＝８．７，７．０，１．３Ｈｚ），７．０７（１Ｈ，ｔｄ，Ｊ＝７．７，１．３Ｈｚ），７．０２（１Ｈ，ｄｄ，Ｊ＝８．４，１．３Ｈｚ），５．８２（１Ｈ，ｄ，Ｊ＝２．５Ｈｚ），３．８８（３Ｈ，ｓ）．Reference production example 14
A mixture of 10 g of succinimide 3-methoxyacrylate described in Reference Production Example 13, 7.4 g of 2-methoxyphenylhydrazine hydrochloride, 1.9 g of sodium hydroxide, 125 mL of dioxane and 125 mL of water was heated at 60 ° C. for 20 hours. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue and 40 mL of concentrated hydrochloric acid were stirred at room temperature for 2 hours. A 28% aqueous sodium hydroxide solution was added to the reaction solution under ice cooling. The obtained residue was washed with a mixed solvent of methyl tert-butyl ether and hexane, and then dried under reduced pressure to obtain 3.4 g of 1- (2-methoxyphenyl) -1H-pyrazol-3-ol.

¹ H-NMR (CDCl ₃ ) δ (ppm): 7.73 (1H, d, J = 2.7 Hz), 7.50 (1H, dd, J = 8.0, 1.6 Hz), 7.26 (1H, ddd, J = 8.7, 7.0, 1.3 Hz), 7.07 (1H, td, J = 7.7, 1.3 Hz), 7.02 (1H, dd, J = 8 .4, 1.3 Hz), 5.82 (1H, d, J = 2.5 Hz), 3.88 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：１．３４（３Ｈ，ｔ，Ｊ＝７．０Ｈｚ），４．４９（２Ｈ，ｑ，Ｊ＝７．０Ｈｚ），６．０１（１Ｈ，ｓ），６．４０（１Ｈ，ｓ）．Reference production example 15
A mixture of 192.4 g of potassium ethyl xanthate, 139.8 g of sodium chloroacetate and 1.1 L of water was stirred at 25 ° C. for 8 hours, 100 mL of concentrated aqueous ammonia was added, and the mixture was further stirred at 25 ° C. for 20 hours. The reaction mixture was extracted with methyl tert-butyl ether, and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. After concentration under reduced pressure, 58.7 g of O-ethyl thiocarbamate was obtained.
O-ethyl thiocarbamate

¹ H-NMR (CDCl ₃ ) δ: 1.34 (3H, t, J = 7.0 Hz), 4.49 (2H, q, J = 7.0 Hz), 6.01 (1H, s), 6 .40 (1H, s).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−ｄ_６）δ：６．８８（１Ｈ，ｄ，Ｊ＝１．７Ｈｚ），７．５０（２Ｈ，ｄｔ，Ｊ＝２．０，８．８Ｈｚ），７．６８（２Ｈ，ｄｔ，Ｊ＝２．２，８．８Ｈｚ），１１．８４（１Ｈ，ｓ）．Reference Production Example 16
A mixture of 10.00 g of 1- (4-chlorophenyl) -2-bromo-1-ethanone, 4.50 g of O-ethyl thiocarbamate described in Reference Production Example 15 and 40 mL of ethanol was heated for 11 hours while heating under reflux. Water was poured into the reaction mixture, and the precipitated solid was filtered and then washed with water to obtain 8.44 g of 4- (4-chlorophenyl) -2,3-dihydro-2-oxothiazole.

¹ H-NMR (DMSO-d ₆ ) δ: 6.88 (1H, d, J = 1.7 Hz), 7.50 (2H, dt, J = 2.0, 8.8 Hz), 7.68 ( 2H, dt, J = 2.2, 8.8 Hz), 11.84 (1H, s).

By the same operation, 4- (4-fluorophenyl) -2,3-dihydro-2-oxothiazole, 4- (4-bromophenyl) -2,3-dihydro-2-oxothiazole, 4- (1- Adamantyl) -2,3-dihydro-2-oxothiazole was obtained.
The physical property values are shown below.

^１Ｈ−ＮＭＲ（ＤＭＳＯ−ｄ_６）δ：６．７６（１Ｈ，ｓ），７．２７（２Ｈ，ｔ，Ｊ＝８．７Ｈｚ），７．６８（２Ｈ，ｄｄ，Ｊ＝５．３，８．０Ｈｚ），１１．７７（１Ｈ，ｓ）．4- (4-Fluorophenyl) -2,3-dihydro-2oxo-thiazole

¹ H-NMR (DMSO-d ₆ ) δ: 6.76 (1H, s), 7.27 (2H, t, J = 8.7 Hz), 7.68 (2H, dd, J = 5.3) 8.0 Hz), 11.77 (1H, s).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−ｄ_６）δ：６．８９（１Ｈ，ｓ），７．６１（２Ｈ，ｄ，Ｊ＝８．５Ｈｚ），７．６４（２Ｈ，ｄ，Ｊ＝９．２Ｈｚ），１１．８５（１Ｈ，ｓ）．4- (4-Bromophenyl) -2,3-dihydro-2-oxothiazole

¹ H-NMR (DMSO-d ₆ ) δ: 6.89 (1H, s), 7.61 (2H, d, J = 8.5 Hz), 7.64 (2H, d, J = 9.2 Hz) , 11.85 (1H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：１．７１−１．７９（６Ｈ，ｍ），１．８３（６Ｈ，ｄ，Ｊ＝２．７Ｈｚ），２．０７（３Ｈ，ｓ），５．６２（１Ｈ，ｄ，Ｊ＝２．２Ｈｚ），１０．０１（１Ｈ，ｓ）．4- (1-adamantyl) -2,3-dihydro-2-oxothiazole

¹ H-NMR (CDCl ₃ ) δ: 1.71-1.79 (6H, m), 1.83 (6H, d, J = 2.7 Hz), 2.07 (3H, s), 5.62 (1H, d, J = 2.2 Hz), 10.01 (1H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．６１−７．５８（１Ｈ，ｍ），７．５４（１Ｈ，ｄｄ，Ｊ＝２．１，０．６Ｈｚ），６．８１（１Ｈ，ｄ，Ｊ＝８．５Ｈｚ），３．８７（３Ｈ，ｓ），３．５７（３Ｈ，ｓ），３．３５（３Ｈ，ｓ），２．２３（３Ｈ，ｓ）．Reference Production Example 17
To a mixture of 5.0 g of 4-methoxy-3-methyl-benzoic acid and 100 ml of tetrahydrofuran was added 4.0 g of oxalyl chloride and 0.2 ml of dimethylformamide at room temperature, and the mixture was stirred for 2.5 hours and then concentrated under reduced pressure. . To this mixture, 150 ml of chloroform, 3.5 g of N, O-dimethyl-hydroxylamine-hydrochloride and 9.3 g of N, N-diisopropylethylamine were added and stirred for 4 hours at room temperature. Water was added and the mixture was extracted with chloroform. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to column chromatography to obtain 6.1 g of 4, N-dimethoxy-3-methyl-N-methylbenzamide (denoted as D2A).

¹ H-NMR (CDCl ₃ ) δ: 7.61-7.58 (1H, m), 7.54 (1H, dd, J = 2.1, 0.6 Hz), 6.81 (1H, d, J = 8.5 Hz), 3.87 (3H, s), 3.57 (3H, s), 3.35 (3H, s), 2.23 (3H, s).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．８３（１Ｈ，ｄｄ，Ｊ＝８．６，２．３Ｈｚ），７．７９−７．７８（１Ｈ，ｍ），６．８４（１Ｈ，ｄ，Ｊ＝８．７Ｈｚ），３．８９（３Ｈ，ｓ），２．９５（２Ｈ，ｑ，Ｊ＝７．２Ｈｚ），２．２５（３Ｈ，ｓ），１．２１（３Ｈ，ｔ，Ｊ＝７．２Ｈｚ）．Reference Production Example 18
A mixture of 5.7 g of D2A described in Reference Production Example 17, 100 ml of tetrahydrofuran, and 43 ml of a 0.95 mol / L ethylmagnesium bromide-tetrahydrofuran solution was stirred with heating under reflux for 6 hours. A saturated aqueous ammonium chloride solution was added at room temperature, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to column chromatography to obtain 4.6 g of 1- (4-methoxy-3-methylphenyl) -propan-1-one (denoted as D3A).

¹ H-NMR (CDCl ₃ ) δ: 7.83 (1H, dd, J = 8.6, 2.3 Hz), 7.79-7.78 (1H, m), 6.84 (1H, d, J = 8.7 Hz), 3.89 (3H, s), 2.95 (2H, q, J = 7.2 Hz), 2.25 (3H, s), 1.21 (3H, t, J = 7.2 Hz).

^１Ｈ−ＮＭＲ（ＣＤＣｌ_３）δ：７．８６（１Ｈ，ｄｄ，Ｊ＝８．６，２．３Ｈｚ），７．８０（１Ｈ，ｄ，Ｊ＝２．２Ｈｚ），６．８６（１Ｈ，ｄ，Ｊ＝８．７Ｈｚ），４．１９−４．１０（３Ｈ，ｍ），３．９０（３Ｈ，ｓ），２．２５（３Ｈ，ｓ），１．４７（３Ｈ，ｄ，Ｊ＝７．２Ｈｚ），１．１９（３Ｈ，ｔ，Ｊ＝７．１Ｈｚ）．Reference Production Example 19
A mixture of 5.2 g of D3A described in Reference Production Example 18, 100 ml of tetrahydrofuran, 4.1 g of potassium tert-butoxide, and 3.6 g of diethyl carbonate was stirred with heating under reflux for 5.5 hours. At room temperature, 20 ml of 6N hydrochloric acid was added and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to column chromatography to obtain 3.5 g of 3- (4-methoxy-3-methylphenyl) -2-methyl-3-oxopropionic acid ethyl ester (denoted as D4A).

¹ H-NMR (CDCl ₃ ) δ: 7.86 (1H, dd, J = 8.6, 2.3 Hz), 7.80 (1H, d, J = 2.2 Hz), 6.86 (1H, d, J = 8.7 Hz), 4.19-4.10 (3H, m), 3.90 (3H, s), 2.25 (3H, s), 1.47 (3H, d, J = 7.2 Hz), 1.19 (3H, t, J = 7.1 Hz).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−Ｄ_６）δ：７．４７−７．４４（２Ｈ，ｍ），７．０７（１Ｈ，ｄ，Ｊ＝８．２Ｈｚ），３．８４（３Ｈ，ｓ），３．６６（３Ｈ，ｓ），２．２０（３Ｈ，ｓ），２．０５（３Ｈ，ｓ）．Reference Production Example 20
A mixture of 3.5 g of D4A described in Reference Production Example 19, 100 ml of toluene, and 7.4 g of methylhydrazine was stirred with heating under reflux for 18 hours. Toluene was distilled off, 3N aqueous hydrochloric acid was added, the precipitate was filtered and washed with hexane to give 3- (4-methoxy-3-methylphenyl) -1,4-dimethyl-5-hydroxy-1H-pyrazole (D5A). 1.4g was obtained.

¹ H-NMR (DMSO-D ₆ ) δ: 7.47-7.44 (2H, m), 7.07 (1H, d, J = 8.2 Hz), 3.84 (3H, s), 3 .66 (3H, s), 2.20 (3H, s), 2.05 (3H, s).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−Ｄ_６）δ：７．４２−７．４０（２Ｈ，ｍ），６．９８（１Ｈ，ｄ，Ｊ＝９．２Ｈｚ），３．８１（３Ｈ，ｓ），３．８０（３Ｈ，ｓ），２．１９（３Ｈ，ｓ），２．１１（３Ｈ，ｓ）．Reference Production Example 21
A mixture of 1.4 g of D5A described in Reference Production Example 20 and 31.8 g of phosphorus oxychloride was stirred at 100 ° C. for 11 hours. The mixture was concentrated under reduced pressure, extracted with ethyl acetate, the organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to column chromatography to obtain 0.4 g of 5-chloro-3- (4-methoxy-3-methylphenyl) -1,4-dimethyl-1H-pyrazole (denoted as D6A).

¹ H-NMR (DMSO-D ₆ ) δ: 7.42-7.40 (2H, m), 6.98 (1H, d, J = 9.2 Hz), 3.81 (3H, s), 3 .80 (3H, s), 2.19 (3H, s), 2.11 (3H, s).

^１Ｈ−ＮＭＲ（ＤＭＳＯ−Ｄ_６）δ：７．３３（１Ｈ，ｓ），７．２４（１Ｈ，ｄ，Ｊ＝８．２Ｈｚ），６．８３（１Ｈ，ｄ，Ｊ＝８．２Ｈｚ），３．７８（３Ｈ，ｓ），２．１５（３Ｈ，ｓ），２．０９（３Ｈ，ｓ）．Reference Production Example 22
A mixture of 0.4 g of D6A described in Reference Production Example 21, 3 ml of 47% hydrobromic acid, and 3 ml of acetic acid was stirred with heating under reflux for 15 hours. The reaction solution was concentrated under reduced pressure, 20 ml of ethyl acetate was added to the residue, and the mixture was stirred at room temperature for 1 hour. The precipitate was filtered, washed with hexane, and dried under reduced pressure to obtain 0.3 g of 4- (5-chloro-1,4-dimethyl-1H-pyrazol-3-yl) -2-methylphenol.

¹ H-NMR (DMSO-D ₆ ) δ: 7.33 (1H, s), 7.24 (1H, d, J = 8.2 Hz), 6.83 (1H, d, J = 8.2 Hz) , 3.78 (3H, s), 2.15 (3H, s), 2.09 (3H, s).

A compound, HA1001-001 to HA3292-7660 (hereinafter referred to as the present compound A) can be obtained according to the above method.
The compounds HA1001-001 to HA3292-7660 are

〔式中、Ｔは、以下に示す置換基番号１〜７６６０に各々対応する置換基〕で示されるテトラゾリノン化合物である。また、下記の［置換基番号；Ｔ］に記載の２−Ｐｙはピリジン−２−イルを表し、３−Ｐｙはピリジン−３−イルを表し、４−Ｐｙはピリジン−４−イルを表し、Ｆはフルオロを表し、Ｃｌはクロロを表し、Ｂｒはブロモを表し、Ｉはヨードを表し、ＣＮはシアノを表し、Ｍｅはメチルを表し、Ｅｔはエチルを表し、Ｐｒはプロピルを表し、ｉ−Ｐｒはイソプロピル基を表し、ＣＦ３はトリフルオロメチルを表し、ＣＨ２ＣＦ３は２，２，２−トリフルオロエチルを表し、ＣＨＦ２はジフルオロメチルを表し、ＯＭｅはメトキシを表し、ＯＣＨ２ＣＦ３は２，２，２−トリフルオロエトキシを表し、ＯＥｔはエトキシを表し、ＯＰｒはプロポキシを表し、ｉ−ＯＰｒはイソプロポキシを表し、ＯＣＦ３はトリフルオロメトキシを表し、ＯＣＨＦ２はジフルオロメトキシを表し、ＳＭｅはメチルチオを表し、Ｓ（Ｏ）Ｍｅはメチルスルフィニルを表し、Ｓ（Ｏ）２Ｍｅはメチルスルホニルを表し、ＳＣＦ３はトリフルオロメチルチオを表し、Ｓ（Ｏ）ＣＦ３はトリフルオロメチルスルフィニルを表し、Ｓ（Ｏ）２ＣＦ３はトリフルオロメチルスルホニルを表し、ＣＯＯＭｅはメトキシカルボニルを表し、ＮＯ２はニトロを表し、ＮＨ２はアミノを表し、ＮＨＭｅはメチルアミノを表し、ＮＭｅ２はジメチルアミノを表し、ＡＣはアセチルを表し、ＡＣＮＨはアセチルアミノを表し、Ｎ−ＡＣ−Ｎ−Ｍｅ−ＮはＮ−アセチル−Ｎ−メチルアミノを表し、ＰＹＲ１はピラゾール−１−イル基を表し、ＰＹＲ３はピラゾール−３−イル基を表し、Ｐｈはフェニルを表し、ｄｉはジを表し、ｔｒｉはトリを表す。

[Wherein, T represents a substituent corresponding to each of substituent numbers 1 to 7660 shown below]. Further, 2-Py described in [Substituent No .; T] below represents pyridin-2-yl, 3-Py represents pyridin-3-yl, 4-Py represents pyridin-4-yl, F represents fluoro, Cl represents chloro, Br represents bromo, I represents iodo, CN represents cyano, Me represents methyl, Et represents ethyl, Pr represents propyl, i- Pr represents an isopropyl group, CF3 represents trifluoromethyl, CH2CF3 represents 2,2,2-trifluoroethyl, CHF2 represents difluoromethyl, OMe represents methoxy, OCH2CF3 represents 2,2,2- Represents trifluoroethoxy, OEt represents ethoxy, OPr represents propoxy, i-OPr represents isopropoxy, OCF3 represents trifluoromethoxy, OCH 2 represents difluoromethoxy, SMe represents methylthio, S (O) Me represents methylsulfinyl, S (O) 2Me represents methylsulfonyl, SCF3 represents trifluoromethylthio, S (O) CF3 represents tri Represents fluoromethylsulfinyl, S (O) 2CF3 represents trifluoromethylsulfonyl, COOMe represents methoxycarbonyl, NO2 represents nitro, NH2 represents amino, NHMe represents methylamino, NMe2 represents dimethylamino AC represents acetyl, ACNH represents acetylamino, N-AC-N-Me-N represents N-acetyl-N-methylamino, PYR1 represents a pyrazol-1-yl group, PYR3 represents pyrazole Represents a -3-yl group, Ph represents phenyl, di represents di, t i represents the birds.

For example, HA1001-0001 represents a compound represented by the formula (H1001), in which T is substituent number 0001, and is represented by the following formula.

[0001: 2-Py], [0002: 3-F-2-Py], [0003: 4-Cl-3-F-2-Py], [0004: 5-Cl-3-F-2-Py] ], [0005: 6-Cl-3-F-2-Py], [0006: 4-Me-3-F-2-Py], [0007: 5-Me-3-F-2-Py], [0008: 6-Me-3-F-2-Py], [0009: 4-CF3-3-F-2-Py], [0010: 5-CF3-3-F-2-Py], [0011] : 6-CF3-3-F-2-Py], [0012: 4-CN-3-F-2-Py], [0013: 5-CN-3-F-2-Py], [0014: 6 -CN-3-F-2-Py], [0015: 4-OMe-3-F-2-Py], [0016: 5-OMe-3-F-2-Py], [0017: -OMe-3-F-2-Py], [0018: 4-F-2-Py], [0019: 3-Cl-4-F-2-Py], [0020: 5-Cl-4-F -2-Py], [0021: 6-Cl-4-F-2-Py], [0022: 3-Me-4-F-2-Py], [0023: 5-Me-4-F-2 -Py], [0024: 6-Me-4-F-2-Py], [0025: 3-CF3-4-F-2-Py], [0026: 5-CF3-4-F-2-Py ], [0027: 6-CF3-4-F-2-Py], [0028: 3-CN-4-F-2-Py], [0029: 5-CN-4-F-2-Py], [0030: 6-CN-4-F-2-Py], [0031: 3-OMe-4-F-2-Py], [0032: 5-OMe-4-F-2-Py], [0 33: 6-OMe-4-F-2-Py], [0034: 5-F-2-Py], [0035: 3-Cl-5-F-2-Py], [0036: 4-Cl- 5-F-2-Py], [0037: 6-Cl-5-F-2-Py], [0038: 3-Me-5-F-2-Py], [0039: 4-Me-5- F-2-Py], [0040: 6-Me-5-F-2-Py], [0041: 3-CF3-5-F-2-Py], [0042: 4-CF3-5-F- 2-Py], [0043: 6-CF3-5-F-2-Py], [0044: 3-CN-5-F-2-Py], [0045: 4-CN-5-F-2- Py], [0046: 6-CN-5-F-2-Py], [0047: 3-OMe-5-F-2-Py], [0048: 4-OMe-5-F-2-Py] , [0049: 6-OMe-5-F-2-Py], [0050: 6-F-2-Py], [0051: 3-Cl-6-F-2-Py], [0052: 4- Cl-6-F-2-Py], [0053: 5-Cl-6-F-2-Py], [0054: 3-Me-6-F-2-Py], [0055: 4-Me- 6-F-2-Py], [0056: 5-Me-6-F-2-Py], [0057: 3-CF3-6-F-2-Py], [0058: 4-CF3-6 F-2-Py], [0059: 5-CF3-6-F-2-Py], [0060: 3-CN-6-F-2-Py], [0061: 4-CN-6-F- 2-Py], [0062: 5-CN-6-F-2-Py], [0063: 3-OMe-6-F-2-Py], [0064: 4-OMe-6-F-2 Py], [0065: 5-OMe-6-F-2-Py], [0066: 3-Cl-2-Py], [0067: 4-Cl-3-Cl-2-Py], [0068: 5-Cl-3-Cl-2-Py], [0069: 6-Cl-3-Cl-2-Py], [0070: 4-Me-3-Cl-2-Py], [0071: 5- Me-3-Cl-2-Py], [0072: 6-Me-3-Cl-2-Py], [0073: 4-CF3-3-Cl-2-Py], [0074: 5-CF3- 3-Cl-2-Py], [0075: 6-CF3-3-Cl-2-Py], [0076: 4-CN-3-Cl-2-Py], [0077: 5-CN-3- Cl-2-Py], [0078: 6-CN-3-Cl-2-Py], [0079: 4-OMe-3-Cl-2-Py] [0080: 5-OMe-3-Cl-2-Py], [0081: 6-OMe-3-Cl-2-Py], [0082: 4-Cl-2-Py], [0083: 3-Cl -4-Cl-2-Py], [0084: 5-Cl-4-Cl-2-Py], [0085: 6-Cl-4-Cl-2-Py], [0086: 3-Me-4 -Cl-2-Py], [0087: 5-Me-4-Cl-2-Py], [0088: 6-Me-4-Cl-2-Py], [0089: 3-CF3-4-Cl -2-Py], [0090: 5-CF3-4-Cl-2-Py], [0091: 6-CF3-4-Cl-2-Py], [0092: 3-CN-4-Cl-2 -Py], [0093: 5-CN-4-Cl-2-Py], [0094: 6-CN-4-Cl-2-Py], [00 95: 3-OMe-4-Cl-2-Py], [0096: 5-OMe-4-Cl-2-Py], [0097: 6-OMe-4-Cl-2-Py], [0098: 5-Cl-2-Py], [0099: 4-Cl-5-Cl-2-Py], [0100: 5-Cl-5-Cl-2-Py],

[0101: 6-Cl-5-Cl-2-Py], [0102: 4-Me-5-Cl-2-Py], [0103: 5-Me-5-Cl-2-Py], [0104 : 6-Me-5-Cl-2-Py], [0105: 4-CF3-5-Cl-2-Py], [0106: 5-CF3-5-Cl-2-Py], [0107: 6 -CF3-5-Cl-2-Py], [0108: 4-CN-5-Cl-2-Py], [0109: 3-CN-5-Cl-2-Py], [0110: 6-CN -5-Cl-2-Py], [0111: 4-OMe-5-Cl-2-Py], [0112: 5-OMe-5-Cl-2-Py], [0113: 6-OMe-5. -Cl-2-Py], [0114: 6-Cl-2-Py], [0115: 3-Cl-6-Cl-2-Py], [0 16: 4-Cl-6-Cl-2-Py], [0117: 5-Cl-6-Cl-2-Py], [0118: 3-Me-6-Cl-2-Py], [0119: 4-Me-6-Cl-2-Py], [0120: 5-Me-6-Cl-2-Py], [0121: 3-CF3-6-Cl-2-Py], [0122: 4- CF3-6-Cl-2-Py], [0123: 5-CF3-6-Cl-2-Py], [0124: 3-CN-6-Cl-2-Py], [0125: 4-CN- 6-Cl-2-Py], [0126: 5-CN-6-Cl-2-Py], [0127: 3-OMe-6-Cl-2-Py], [0128: 4-OMe-6-6 Cl-2-Py], [0129: 5-OMe-6-Cl-2-Py], [0130: 3-Br-2-Py], [013 : 4-Cl-3-Br-2-Py], [0132: 5-Cl-3-Br-2-Py], [0133: 6-Cl-3-Br-2-Py], [0134: 4 -Me-3-Br-2-Py], [0135: 5-Me-3-Br-2-Py], [0136: 6-Me-3-Br-2-Py], [0137: 4-CF3 -3-Br-2-Py], [0138: 5-CF3-3-3-Br-2-Py], [0139: 6-CF3-3-Br-2-Py], [0140: 4-CN-3 -Br-2-Py], [0141: 5-CN-3-Br-2-Py], [0142: 6-CN-3-Br-2-Py], [0143: 4-OMe-3-Br -2-Py], [0144: 5-OMe-3-Br-2-Py], [0145: 6-OMe-3-Br-2-Py], [0 146: 4-Br-2-Py], [0147: 3-Cl-4-Br-2-Py], [0148: 5-Cl-4-Br-2-Py], [0149: 6-Cl- 4-Br-2-Py], [0150: 3-Me-4-Br-2-Py], [0151: 5-Me-4-Br-2-Py], [0152: 6-Me-4- Br-2-Py], [0153: 3-CF3-4-Br-2-Py], [0154: 5-CF3-4-Br-2-Py], [0155: 6-CF3-4-Br- 2-Py], [0156: 3-CN-4-Br-2-Py], [0157: 5-CN-4-Br-2-Py], [0158: 6-CN-4-Br-2- Py], [0159: 3-OMe-4-Br-2-Py], [0160: 5-OMe-4-Br-2-Py], [0161 6-OMe-4-Br-2-Py], [0162: 5-Br-2-Py], [0163: 3-Cl-5-Br-2-Py], [0164: 4-Cl-5 Br-2-Py], [0165: 6-Cl-5-Br-2-Py], [0166: 3-Me-5-Br-2-Py], [0167: 4-Me-5-Br- 2-Py], [0168: 6-Me-5-Br-2-Py], [0169: 3-CF3-5-Br-2-Py], [0170: 4-CF3-5-Br-2-] Py], [0171: 6-CF3-5-Br-2-Py], [0172: 3-CN-5-Br-2-Py], [0173: 4-CN-5-Br-2-Py] [0174: 6-CN-5-Br-2-Py], [0175: 3-OMe-5-Br-2-Py], [0176: 4- Me-5-Br-2-Py], [0177: 6-OMe-5-Br-2-Py], [0178: 6-Br-2-Py], [0179: 3-Cl-6-Br- 2-Py], [0180: 4-Cl-6-Br-2-Py], [0181: 5-Cl-6-Br-2-Py], [0182: 3-Me-6-Br-2- Py], [0183: 4-Me-6-Br-2-Py], [0184: 5-Me-6-Br-2-Py], [0185: 3-CF3-6-Br-2-Py] [0186: 4-CF3-6-Br-2-Py], [0187: 5-CF3-6-Br-2-Py], [0188: 3-CN-6-Br-2-Py], [ 0189: 4-CN-6-Br-2-Py], [0190: 5-CN-6-Br-2-Py], [0191: 3-OMe- 6-Br-2-Py], [0192: 4-OMe-6-Br-2-Py], [0193: 5-OMe-6-Br-2-Py], [0194: 3-I-2- Py], [0195: 4-Cl-3-I-2-Py], [0196: 5-Cl-3-I-2-Py], [0197: 6-Cl-3-I-2-Py] [0198: 4-Me-3-I-2-Py], [0199: 5-Me-3-I-2-Py], [0200: 6-Me-3-I-2-Py],

[0201: 4-CF3-3-1-I-2-Py], [0202: 5-CF3-3-1-I-2-Py], [0203: 6-CF3-3-3-I-2-Py], [0204] : 4-CN-3-I-2-Py], [0205: 5-CN-3-I-2-Py], [0206: 6-CN-3-I-2-Py], [0207: 4 -OMe-3-I-2-Py], [0208: 5-OMe-3-I-2-Py], [0209: 6-OMe-3-I-2-Py], [0210: 4-I -2-Py], [0211: 3-Cl-4-I-2-Py], [0212: 5-Cl-4-I-2-Py], [0213: 6-Cl-4-I-2 -Py], [0214: 3-Me-4-I-2-Py], [0215: 5-Me-4-I-2-Py], [0216: 6-Me-4-I-2- y], [0217: 3-CF3-4-I-2-Py], [0218: 5-CF3-4-I-2-Py], [0219: 6-CF3-4-I-2-Py] [0220: 3-CN-4-I-2-Py], [0221: 5-CN-4-I-2-Py], [0222: 6-CN-4-I-2-Py], [ 0223: 3-OMe-4-I-2-Py], [0224: 5-OMe-4-I-2-Py], [0225: 6-OMe-4-I-2-Py], [0226: 5-I-2-Py], [0227: 3-Cl-5-I-2-Py], [0228: 4-Cl-5-I-2-Py], [0229: 6-Cl-5 I-2-Py], [0230: 3-Me-5-I-2-Py], [0231: 4-Me-5-I-2-Py], [0232: 6-Me-5- -2-Py], [0233: 3-CF3-5-I-2-Py], [0234: 4-CF3-5-I-2-Py], [0235: 6-CF3-5-I-2 -Py], [0236: 3-CN-5-I-2-Py], [0237: 4-CN-5-I-2-Py], [0238: 6-CN-5-I-2-Py ], [0239: 3-OMe-5-I-2-Py], [0240: 4-OMe-5-I-2-Py], [0241: 6-OMe-5-I-2-Py], [0242: 6-I-2-Py], [0243: 3-Cl-6-I-2-Py], [0244: 4-Cl-6-I-2-Py], [0245: 5-Cl -6-I-2-Py], [0246: 3-Me-6-I-2-Py], [0247: 4-Me-6-I-2-Py], [0248: 5-Me -6-I-2-Py], [0249: 3-CF3-6-I-2-Py], [0250: 4-CF3-6-I-2-Py], [0251: 5-CF3-6. -I-2-Py], [0252: 3-CN-6-I-2-Py], [0253: 4-CN-6-I-2-Py], [0254: 5-CN-6-I -2-Py], [0255: 3-OMe-6-I-2-Py], [0256: 4-OMe-6-I-2-Py], [0257: 5-OMe-6-I-2 -Py], [0258: 3-Me-2-Py], [0259: 4-Cl-3-Me-2-Py], [0260: 5-Cl-3-Me-2-Py], [0261 : 6-Cl-3-Me-2-Py], [0262: 4-Me-3-Me-2-Py], [0263: 5-Me-3-Me-2-Py], 0264: 6-Me-3-Me-2-Py], [0265: 4-CF3-3-Me-2-Py], [0266: 5-CF3-3-Me-2-Py], [0267: 6-CF3-3-Me-2-Py], [0268: 4-CN-3-Me-2-Py], [0269: 5-CN-3-Me-2-Py], [0270: 6- CN-3-Me-2-Py], [0271: 4-OMe-3-Me-2-Py], [0272: 5-OMe-3-Me-2-Py], [0273: 6-OMe- 3-Me-2-Py], [0274: 4-Me-2-Py], [0275: 3-Cl-4-Me-2-Py], [0276: 5-Cl-4-Me-2-] Py], [0277: 6-Cl-4-Me-2-Py], [0278: 3-Me-4-Me-2-Py], [0 79: 5-Me-4-Me-2-Py], [0280: 6-Me-4-Me-2-Py], [0281: 3-CF3-4-Me-2-Py], [0282: 5-CF3-4-Me-2-Py], [0283: 6-CF3-4-Me-2-Py], [0284: 3-CN-4-Me-2-Py], [0285: 5- CN-4-Me-2-Py], [0286: 6-CN-4-Me-2-Py], [0287: 3-OMe-4-Me-2-Py], [0288: 5-OMe- 4-Me-2-Py], [0289: 6-OMe-4-Me-2-Py], [0290: 5-Me-2-Py], [0291: 3-Cl-5-Me-2-] Py], [0292: 4-Cl-5-Me-2-Py], [0293: 6-Cl-5-Me-2-Py], [0294 : 3-Me-5-Me-2-Py], [0295: 4-Me-5-Me-2-Py], [0296: 6-Me-5-Me-2-Py], [0297: 3 -CF3-5-Me-2-Py], [0298: 4-CF3-5-Me-2-Py], [0299: 6-CF3-5-Me-2-Py], [0300: 3-CN -5-Me-2-Py],

[0301: 4-CN-5-Me-2-Py], [0302: 6-CN-5-Me-2-Py], [0303: 3-OMe-5-Me-2-Py], [0304 : 4-OMe-5-Me-2-Py], [0305: 6-OMe-5-Me-2-Py], [0306: 6-Me-2-Py], [0307: 3-Cl-6 -Me-2-Py], [0308: 4-Cl-6-Me-2-Py], [0309: 5-Cl-6-Me-2-Py], [0310: 3-Me-6-Me -2-Py], [0311: 4-Me-6-Me-2-Py], [0312: 5-Me-6-Me-2-Py], [0313: 3-CF3-6-Me-2 -Py], [0314: 4-CF3-6-Me-2-Py], [0315: 5-CF3-6-Me-2-Py], [0 16: 3-CN-6-Me-2-Py], [0317: 4-CN-6-Me-2-Py], [0318: 5-CN-6-Me-2-Py], [0319: 3-OMe-6-Me-2-Py], [0320: 4-OMe-6-Me-2-Py], [0321: 5-OMe-6-Me-2-Py], [0322: 3- OMe-2-Py], [0323: 4-Cl-3-OMe-2-Py], [0324: 5-Cl-3-OMe-2-Py], [0325: 6-Cl-3-OMe- 2-Py], [0326: 4-Me-3-OMe-2-Py], [0327: 5-Me-3-OMe-2-Py], [0328: 6-Me-3-OMe-2- Py], [0329: 4-CF3-3-OMe-2-Py], [0330: 5-CF3-3-OMe-2- y], [0331: 6-CF3-3-OMe-2-Py], [0332: 4-CN-3-OMe-2-Py], [0333: 5-CN-3-OMe-2-Py] [0334: 6-CN-3-OMe-2-Py], [0335: 4-OMe-3-OMe-2-Py], [0336: 5-OMe-3-OMe-2-Py], [ 0337: 6-OMe-3-OMe-2-Py], [0338: 4-OMe-2-Py], [0339: 3-Cl-4-OMe-2-Py], [0340: 5-Cl- 4-OMe-2-Py], [0341: 6-Cl-4-OMe-2-Py], [0342: 3-Me-4-OMe-2-Py], [0343: 5-Me-4- OMe-2-Py], [0344: 6-Me-4-OMe-2-Py], [0345: 3-C F3-4-OMe-2-Py], [0346: 5-CF3-4-OMe-2-Py], [0347: 6-CF3-4-OMe-2-Py], [0348: 3-CN- 4-OMe-2-Py], [0349: 5-CN-4-OMe-2-Py], [0350: 6-CN-4-OMe-2-Py], [0351: 3-OMe-4- OMe-2-Py], [0352: 5-OMe-4-OMe-2-Py], [0353: 6-OMe-4-OMe-2-Py], [0354: 5-OMe-2-Py] [0355: 3-Cl-5-OMe-2-Py], [0356: 4-Cl-5-OMe-2-Py], [0357: 6-Cl-5-OMe-2-Py], [ 0358: 3-Me-5-OMe-2-Py], [0359: 4-Me-5-OMe-2- y], [0360: 6-Me-5-OMe-2-Py], [0361: 3-CF3-5-OMe-2-Py], [0362: 4-CF3-5-OMe-2-Py] [0363: 6-CF3-5-OMe-2-Py], [0364: 3-CN-5-OMe-2-Py], [0365: 4-CN-5-OMe-2-Py], [ 0366: 6-CN-5-OMe-2-Py], [0367: 3-OMe-5-OMe-2-Py], [0368: 4-OMe-5-OMe-2-Py], [0369: 6-OMe-5-OMe-2-Py], [0370: 6-OMe-2-Py], [0371: 3-Cl-6-OMe-2-Py], [0372: 4-Cl-6 OMe-2-Py], [0373: 5-Cl-6-OMe-2-Py], [0374: -Me-6-OMe-2-Py], [0375: 4-Me-6-OMe-2-Py], [0376: 5-Me-6-OMe-2-Py], [0377: 3-CF3 -6-OMe-2-Py], [0378: 4-CF3-6-OMe-2-Py], [0379: 5-CF3-6-OMe-2-Py], [0380: 3-CN-6 -OMe-2-Py], [0391: 4-CN-6-OMe-2-Py], [0382: 5-CN-6-OMe-2-Py], [0383: 3-OMe-6-OMe -2-Py], [0384: 4-OMe-6-OMe-2-Py], [0385: 5-OMe-6-OMe-2-Py], [0386: 3-CF3-2-Py], [0387: 4-Cl-3-CF3-2-Py], [0388: 5-Cl-3-CF3- 2-Py], [0389: 6-Cl-3-CF3-2-Py], [0390: 4-Me-3-CF3-2-Py], [0391: 5-Me-3-CF3-2- Py], [0392: 6-Me-3-CF3-2-Py], [0393: 4-CF3-3-CF3-2-Py], [0394: 5-CF3-3-CF3-2-Py] [0395: 6-CF3-3-CF3-2-Py], [0396: 4-CN-3-CF3-2-Py], [0397: 5-CN-3-CF3-2-Py], [ 0398: 6-CN-3-CF3-2-Py], [0399: 4-OMe-3-CF3-2-Py], [0400: 5-OMe-3-CF3-2-Py],

[0401: 6-OMe-3-CF3-2-Py], [0402: 4-CF3-2-Py], [0403: 3-Cl-4-CF3-2-Py], [0404: 5-Cl -4-CF3-2-Py], [0405: 6-Cl-4-CF3-2-Py], [0406: 3-Me-4-CF3-2-Py], [0407: 5-Me-4 -CF3-2-Py], [0408: 6-Me-4-CF3-2-Py], [0409: 3-CF3-4-CF3-2-Py], [0410: 5-CF3-4-CF3 -2-Py], [0411: 6-CF3-4-CF3-2-Py], [0412: 3-CN-4-CF3-2-Py], [0413: 5-CN-4-CF3-2 -Py], [0414: 6-CN-4-CF3-2-Py], [0415: 3-OMe- -CF3-2-Py], [0416: 5-OMe-4-CF3-2-Py], [0417: 6-OMe-4-CF3-2-Py], [0418: 5-CF3-2-Py] ], [0419: 3-Cl-5-CF3-2-Py], [0420: 4-Cl-5-CF3-2-Py], [0421: 6-Cl-5-CF3-2-Py], [0422: 3-Me-5-CF3-2-Py], [0423: 4-Me-5-CF3-2-Py], [0424: 6-Me-5-CF3-2-Py], [0425] : 3-CF3-5-CF3-2-Py], [0426: 4-CF3-5-CF3-2-Py], [0427: 6-CF3-5-CF3-2-Py], [0428: 3 -CN-5-CF3-2-Py], [0429: 4-CN-5-CF3-2-Py] [0430: 6-CN-5-CF3-2-Py], [0431: 3-OMe-5-CF3-2-Py], [0432: 4-OMe-5-CF3-2-Py], [0433 : 6-OMe-5-CF3-2-Py], [0434: 6-CF3-2-Py], [0435: 3-Cl-6-CF3-2-Py], [0436: 4-Cl-6 -CF3-2-Py], [0437: 5-Cl-6-CF3-2-Py], [0438: 3-Me-6-CF3-2-Py], [0439: 4-Me-6-CF3 -2-Py], [0440: 5-Me-6-CF3-2-Py], [0441: 3-CF3-6-CF3-2-Py], [0442: 4-CF3-6-CF3-2 -Py], [0443: 5-CF3-6-CF3-2-Py], [0444: 3-CN. -6-CF3-2-Py], [0445: 4-CN-6-CF3-2-Py], [0446: 5-CN-6-CF3-2-Py], [0447: 3-OMe-6. -CF3-2-Py], [0448: 4-OMe-6-CF3-2-Py], [0449: 5-OMe-6-CF3-2-Py], [0450: 3-OCF3-2-Py ], [0451: 4-Cl-3-OCF3-2-Py], [0452: 5-Cl-3-OCF3-2-Py], [0453: 6-Cl-3-OCF3-2-Py], [0454: 4-Me-3-OCF3-2-Py], [0455: 5-Me-3-OCF3-2-Py], [0456: 6-Me-3-OCF3-2-Py], [0457] : 4-CF3-3-OCF3-2-Py], [0458: 5-CF3-3- CF3-2-Py], [0459: 6-CF3-3-OCF3-2-Py], [0460: 4-CN-3-OCF3-2-Py], [0461: 5-CN-3-OCF3- 2-Py], [0462: 6-CN-3-OCF3-2-Py], [0463: 4-OMe-3-OCF3-2-Py], [0464: 5-OMe-3-OCF3-2- Py], [0465: 6-OMe-3-OCF3-2-Py], [0466: 4-OCF3-2-Py], [0467: 3-Cl-4-OCF3-2-Py], [0468: 5-Cl-4-OCF3-2-Py], [0469: 6-Cl-4-OCF3-2-Py], [0470: 3-Me-4-OCF3-2-Py], [0471: 5- Me-4-OCF3-2-Py], [0472: 6-Me- -OCF3-2-Py], [0473: 3-CF3-4-OCF3-2-Py], [0474: 5-CF3-4-OCF3-2-Py], [0475: 6-CF3-4-OCF3 -2-Py], [0476: 3-CN-4-OCF3-2-Py], [0477: 5-CN-4-OCF3-2-Py], [0478: 6-CN-4-OCF3-2 -Py], [0479: 3-OMe-4-OCF3-2-Py], [0480: 5-OMe-4-OCF3-2-Py], [0481: 6-OMe-4-OCF3-2-Py ], [0482: 5-OCF3-2-Py], [0483: 3-Cl-5-OCF3-2-Py], [0484: 4-Cl-5-OCF3-2-Py], [0485: 6 -Cl-5-OCF3-2-Py], [0486: 3- Me-5-OCF3-2-Py], [0487: 4-Me-5-OCF3-2-Py], [0488: 6-Me-5-OCF3-2-Py], [0489: 3-CF3- 5-OCF3-2-Py], [0490: 4-CF3-5-OCF3-2-Py], [0491: 6-CF3-5-OCF3-2-Py], [0492: 3-CN-5 OCF3-2-Py], [0493: 4-CN-5-OCF3-2-Py], [0494: 6-CN-5-OCF3-2-Py], [0495: 3-OMe-5-OCF3- 2-Py], [0496: 4-OMe-5-OCF3-2-Py], [0497: 6-OMe-5-OCF3-2-Py], [0498: 6-OCF3-2-Py], [ 0499: 3-Cl-6-OCF3-2-Py], [050 : 4-Cl-6-OCF3-2-Py],

[0501: 5-Cl-6-OCF3-2-Py], [0502: 3-Me-6-OCF3-2-Py], [0503: 4-Me-6-OCF3-2-Py], [0504] : 5-Me-6-OCF3-2-Py], [0505: 3-CF3-6-OCF3-2-Py], [0506: 4-CF3-6-OCF3-2-Py], [0507: 5 -CF3-6-OCF3-2-Py], [0508: 3-CN-6-OCF3-2-Py], [0509: 4-CN-6-OCF3-2-Py], [0510: 5-CN -6-OCF3-2-Py], [0511: 3-OMe-6-OCF3-2-Py], [0512: 4-OMe-6-OCF3-2-Py], [0513: 5-OMe-6. -OCF3-2-Py], [0514: 3-CHF2-2 y], [0515: 4-Cl-3-CHF2-2-Py], [0516: 5-Cl-3-CHF2-2-Py], [0517: 6-Cl-3-CHF2-2-Py] [0518: 4-Me-3-CHF2-2Py], [0519: 5-Me-3-CHF2-2Py], [0520: 6-Me-3-CHF2-2Py], [ 0521: 4-CF3-3-CHF2-2Py], [0522: 5-CF3-3-CHF2-2Py], [0523: 6-CF3-3-CHF2-2Py], [0524: 4-CN-3-CHF2-2-Py], [0525: 5-CN-3-CHF2-2-Py], [0526: 6-CN-3-CHF2-2-Py], [0527: 4- OMe-3-CHF2-2Py], [0528: 5-OMe-3 CHF2-2-Py], [0529: 6-OMe-3-CHF2-2-Py], [0530: 4-CHF2-2-Py], [0531: 3-Cl-4-CHF2-2-Py] [0532: 5-Cl-4-CHF2-2-Py], [0533: 6-Cl-4-CHF2-2-Py], [0534: 3-Me-4-CHF2-2-Py], [ 0535: 5-Me-4-CHF2-2Py], [0536: 6-Me-4-CHF2-2Py], [0537: 3-CF3-4-CHF2-2Py], [0538: 5-CF3-4-CHF2-2Py], [0539: 6-CF3-4-CHF2-2Py], [0540: 3-CN-4-CHF2-2Py], [0541: 5- CN-4-CHF2-2-Py], [0542: 6-CN- 4-CHF2-2-Py], [0543: 3-OMe-4-CHF2-2-Py], [0544: 5-OMe-4-CHF2-2-Py], [0545: 6-OMe-4- CHF2-2-Py], [0546: 5-CHF2-2-Py], [0547: 3-Cl-5-CHF2-2-Py], [0548: 4-Cl-5-CHF2-2-Py] [0549: 6-Cl-5-CHF2-2Py], [0550: 3-Me-5-CHF2-2Py], [0551: 4-Me-5-CHF2-2Py], [ 0552: 6-Me-5-CHF2-2Py], [0553: 3-CF3-5-CHF2-2Py], [0554: 4-CF3-5-CHF2-2Py], [0555: 6-CF3-5-CHF2-2Py], [0556: 3 CN-5-CHF2-2-Py], [0557: 4-CN-5-CHF2-2-Py], [0558: 6-CN-5-CHF2-2-Py], [0559: 3-OMe- 5-CHF2-2-Py], [0560: 4-OMe-5-CHF2-2-Py], [0561: 6-OMe-5-CHF2-2-Py], [0562: 6-CHF2-2 Py], [0563: 3-Cl-6-CHF2-2-Py], [0564: 4-Cl-6-CHF2-2-Py], [0565: 5-Cl-6-CHF2-2-Py] [0566: 3-Me-6-CHF2-2Py], [0567: 4-Me-6-CHF2-2Py], [0568: 5-Me-6-CHF2-2Py], [ 0568: 3-CF3-6-CHF2-2Py], [0570 4-CF3-6-CHF2-2Py], [0571: 5-CF3-6-CHF2-2Py], [0572: 3-CN-6-CHF2-2Py], [0573: 4- CN-6-CHF2-2-Py], [0574: 5-CN-6-CHF2-2-Py], [0575: 3-OMe-6-CHF2-2-Py], [0576: 4-OMe- 6-CHF2-2-Py], [0577: 5-OMe-6-CHF2-2-Py], [0578: 3-OCHF2-2-Py], [0579: 4-Cl-3-OCHF2-2 Py], [0580: 5-Cl-3-OCHF2-2-Py], [0581: 6-Cl-3-OCHF2-2-Py], [0582: 4-Me-3-OCHF2-2-Py] [0583: 5-Me-3-OCHF2-2-P y], [0584: 6-Me-3-OCHF2-2-Py], [0585: 4-CF3-3-OCHF2-2-Py], [0586: 5-CF3-3-OCHF2-2-Py] [0587: 6-CF3-3-OCHF2-2-Py], [0588: 4-CN-3-OCHF2-2-Py], [0589: 5-CN-3-OCHF2-2-Py], [ 0590: 6-CN-3-OCHF2-2-Py], [0591: 4-OMe-3-OCHF2-2-Py], [0592: 5-OMe-3-OCHF2-2-Py], [0593: 6-OMe-3-OCHF2-2-Py], [0594: 4-OCHF2-2-Py], [0595: 3-Cl-4-OCHF2-2-Py], [0596: 5-Cl-4- OCHF2-2-Py], [059 : 6-Cl-4-OCHF2-2-Py], [0598: 3-Me-4-OCHF2-2-Py], [0599: 5-Me-4-OCHF2-2-Py], [0600: 6 -Me-4-OCHF2-2-Py],

[0601: 3-CF3-4-OCHF2-2-Py], [0602: 5-CF3-4-OCHF2-2-Py], [0603: 6-CF3-4-OCHF2-2-Py], [0604] : 3-CN-4-OCHF2-2-Py], [0605: 5-CN-4-OCHF2-2-Py], [0606: 6-CN-4-OCHF2-2-Py], [0607: 3 -OMe-4-OCHF2-2-Py], [0608: 5-OMe-4-OCHF2-2-Py], [0609: 6-OMe-4-OCHF2-2-Py], [0610: 5-OCHF2 -2-Py], [0611: 3-Cl-5-OCHF2-2-Py], [0612: 4-Cl-5-OCHF2-2-Py], [0613: 6-Cl-5-OCHF2-2 -Py], [0614: 3 Me-5-OCHF2-2-Py], [0615: 4-Me-5-OCHF2-2-Py], [0616: 6-Me-5-OCHF2-2-Py], [0617: 3-CF3- 5-OCHF2-2-Py], [0618: 4-CF3-5-OCHF2-2-Py], [0619: 6-CF3-5-OCHF2-2-Py], [0620: 3-CN-5 OCHF2-2-Py], [0621: 4-CN-5-OCHF2-2-Py], [0622: 6-CN-5-OCHF2-2-Py], [0623: 3-OMe-5-OCHF2- 2-Py], [0624: 4-OMe-5-OCHF2-2-Py], [0625: 6-OMe-5-OCHF2-2-Py], [0626: 6-OCHF2-2-Py], [ 0627: 3-Cl-6-O HF2-2-Py], [0628: 4-Cl-6-OCHF2-2-Py], [0629: 5-Cl-6-OCHF2-2-Py], [0630: 3-Me-6-OCHF2- 2-Py], [0631: 4-Me-6-OCHF2-2-Py], [0632: 5-Me-6-OCHF2-2-Py], [0633: 3-CF3-6-OCHF2-2 Py], [0634: 4-CF3-6-OCHF2-2Py], [0635: 5-CF3-6-OCHF2-2Py], [0636: 3-CN-6-OCHF2-2Py] [0637: 4-CN-6-OCHF2-2-Py], [0638: 5-CN-6-OCHF2-2-Py], [0639: 3-OMe-6-OCHF2-2-Py], [ 0640: 4-OMe-6-OCHF2 -2-Py], [0641: 5-OMe-6-OCHP2-2-2-Py], [0642: 3-Et-2-Py], [0643: 4-Cl-3-Et-2-Py], [0644: 5-Cl-3-Et-2-Py], [0645: 6-Cl-3-Et-2-Py], [0646: 4-Me-3-Et-2-Py], [0647] : 5-Me-3-Et-2-Py], [0648: 6-Me-3-Et-2-Py], [0649: 4-CF3-3-Et-2-Py], [0650: 5 -CF3-3-Et-2-Py], [0651: 6-CF3-3-Et-2-Py], [0652: 4-CN-3-Et-2-Py], [0653: 5-CN -3-Et-2-Py], [0654: 6-CN-3-Et-2-Py], [0655: 4-OMe-3-Et 2-Py], [0656: 5-OMe-3-Et-2-Py], [0657: 6-OMe-3-Et-2-Py], [0658: 4-Et-2-Py], [ 0659: 3-Cl-4-Et-2-Py], [0660: 5-Cl-4-Et-2-Py], [0661-6-Cl-4-Et-2-Py], [0662: 3-Me-4-Et-2-Py], [0663: 5-Me-4-Et-2-Py], [0664: 6-Me-4-Et-2-Py], [0665: 3- CF3-4-Et-2-Py], [0666: 5-CF3-4-Et-2-Py], [0667: 6-CF3-4-Et-2-Py], [0668: 3-CN- 4-Et-2-Py], [0669: 5-CN-4-Et-2-Py], [0670: 6-CN-4-Et-2- y], [0671: 3-OMe-4-Et-2-Py], [0672: 5-OMe-4-Et-2-Py], [0673: 6-OMe-4-Et-2-Py] [0674: 5-Et-2-Py], [0675: 3-Cl-5-Et-2-Py], [0676: 4-Cl-5-Et-2-Py], [0677: 6- Cl-5-Et-2-Py], [0678: 3-Me-5-Et-2-Py], [0679: 4-Me-5-Et-2-Py], [0680: 6-Me- 5-Et-2-Py], [0681: 3-CF3-5-Et-2-Py], [0682: 4-CF3-5-Et-2-Py], [0683: 6-CF3-5 Et-2-Py], [0684: 3-CN-5-Et-2-Py], [0685: 4-CN-5-Et-2-Py] [0686: 6-CN-5-Et-2-Py], [0687: 3-OMe-5-Et-2-Py], [0688: 4-OMe-5-Et-2-Py], [ 0689: 6-OMe-5-Et-2-Py], [0690: 6-Et-2-Py], [0691: 3-Cl-6-Et-2-Py], [0692: 4-Cl- 6-Et-2-Py], [0693: 5-Cl-6-Et-2-Py], [0694: 3-Me-6-Et-2-Py], [0695: 4-Me-6- Et-2-Py], [0696: 5-Me-6-Et-2-Py], [0697: 3-CF3-6-Et-2-Py], [0698: 4-CF3-6-Et- 2-Py], [0699: 5-CF3-6-Et-2-Py], [0700: 3-CN-6-Et-2-Py],

[0701: 4-CN-6-Et-2-Py], [0702: 5-CN-6-Et-2-Py], [0703: 3-OMe-6-Et-2-Py], [0704 : 4-OMe-6-Et-2-Py], [0705: 5-OMe-6-Et-2-Py], [0706: 3-CH2CF3-2-Py], [0707: 4-Cl-3] -CH2CF3-2-Py], [0708: 5-Cl-3-CH2CF3-2-Py], [0709: 6-Cl-3-CH2CF3-2-Py], [0710: 4-Me-3-CH2CF3 -2-Py], [0711: 5-Me-3-CH2CF3-2-Py], [0712: 6-Me-3-CH2CF3-2-Py], [0713: 4-CF3-3-CH2CF3-2 -Py], [0714: 5-CF3-3-CH CF3-2-Py], [0715: 6-CF3-3-CH2CF3-2-Py], [0716: 4-CN-3-CH2CF3-2-Py], [0717: 5-CN-3-CH2CF3- 2-Py], [0718: 6-CN-3-CH2CF3-2-Py], [0719: 4-OMe-3-CH2CF3-2-Py], [0720: 5-OMe-3-CH2CF3-2- Py], [0721: 6-OMe-3-CH2CF3-2-Py], [0722: 4-CH2CF3-2-Py], [0723: 3-Cl-4-CH2CF3-2-Py], [0724: 5-Cl-4-CH2CF3-2-Py], [0725: 6-Cl-4-CH2CF3-2-Py], [0726: 3-Me-4-CH2CF3-2-Py], [0727: 5- Me- -CH2CF3-2-Py], [0728: 6-Me-4-CH2CF3-2-Py], [0729: 3-CF3-4-CH2CF3-2-Py], [0730: 5-CF3-4-CH2CF3 -2Py], [0731: 6-CF3-4-CH2CF3-2-Py], [0732: 3-CN-4-CH2CF3-2-Py], [0733: 5-CN-4-CH2CF3-2 -Py], [0734: 6-CN-4-CH2CF3-2-Py], [0735: 3-OMe-4-CH2CF3-2-Py], [0736: 5-OMe-4-CH2CF3-2-Py ], [0737: 6-OMe-4-CH2CF3-2-Py], [0738: 5-CH2CF3-2-Py], [0739: 3-Cl-5-CH2CF3-2-Py], [0740: 4-Cl-5-CH2CF3-2-Py], [0741: 6-Cl-5-CH2CF3-2-Py], [0742: 3-Me-5-CH2CF3-2-Py], [0743: 4- Me-5-CH2CF3-2-Py], [0744: 6-Me-5-CH2CF3-2-Py], [0745: 3-CF3-5-CH2CF3-2-Py], [0746: 4-CF3- 5-CH2CF3-2-Py], [0747: 6-CF3-5-CH2CF3-2-Py], [0748: 3-CN-5-CH2CF3-2-Py], [0749: 4-CN-5 CH2CF3-2-Py], [0750: 6-CN-5-CH2CF3-2-Py], [0751: 3-OMe-5-CH2CF3-2-Py], [0752: 4-OMe-5-CH2CF3- 2- y], [0753: 6-OMe-5-CH2CF3-2-Py], [0754: 6-CH2CF3-2-Py], [0755: 3-Cl-6-CH2CF3-2-Py], [0756: 4-Cl-6-CH2CF3-2-Py], [0757: 5-Cl-6-CH2CF3-2-Py], [0758: 3-Me-6-CH2CF3-2-Py], [0759: 4- Me-6-CH2CF3-2-Py], [0760: 5-Me-6-CH2CF3-2-Py], [0761: 3-CF3-6-CH2CF3-2-Py], [0762: 4-CF3- 6-CH2CF3-2-Py], [0763: 5-CF3-6-CH2CF3-2-Py], [0764: 3-CN-6-CH2CF3-2-Py], [0765: 4-CN-6 CH2CF -2-Py], [0766: 5-CN-6-CH2CF3-2-Py], [0767: 3-OMe-6-CH2CF3-2-Py], [0768: 4-OMe-6-CH2CF3-2 -Py], [0769: 5-OMe-6-CH2CF3-2-Py], [0770: 3-OEt-2-Py], [0771: 4-Cl-3-OEt-2-Py], [0772]. : 5-Cl-3-OEt-2-Py], [0773: 6-Cl-3-OEt-2-Py], [0774: 4-Me-3-OEt-2-Py], [0775: 5 -Me-3-OEt-2-Py], [0776: 6-Me-3-OEt-2-Py], [0777: 4-CF3-3-OEt-2-Py], [0778: 5-CF3 -3-OEt-2-Py], [0779: 6-CF3-3-O Et-2-Py], [0780: 4-CN-3-OEt-2-Py], [0781: 5-CN-3-OEt-2-Py], [0782: 6-CN-3-OEt- 2-Py], [0783: 4-OMe-3-OEt-2-Py], [0784: 5-OMe-3-OEt-2-Py], [0785: 6-OMe-3-OEt-2- Py], [0786: 4-OEt-2-Py], [0787: 3-Cl-4-OEt-2-Py], [0788: 5-Cl-4-OEt-2-Py], [0789: 6-Cl-4-OEt-2-Py], [0790: 3-Me-4-OEt-2-Py], [0791: 5-Me-4-OEt-2-Py], [0792: 6- Me-4-OEt-2-Py], [0793: 3-CF3-4-OEt-2-Py], [07 4: 5-CF3-4-OEt-2-Py], [0795: 6-CF3-4-OEt-2-Py], [0796: 3-CN-4-OEt-2-Py], [0797: 5-CN-4-OEt-2-Py], [0798: 6-CN-4-OEt-2-Py], [0799: 3-OMe-4-OEt-2-Py], [0800: 5- OMe-4-OEt-2-Py],

[0801: 6-OMe-4-OEt-2-Py], [0802: 5-OEt-2-Py], [0803: 3-Cl-5-OEt-2-Py], [0804: 4-Cl -5-OEt-2-Py], [0805: 6-Cl-5-OEt-2-Py], [0806: 3-Me-5-OEt-2-Py], [0807: 4-Me-5. -OEt-2-Py], [0808: 6-Me-5-OEt-2-Py], [0809: 3-CF3-5-OEt-2-Py], [0810: 4-CF3-5-OEt -2-Py], [0811: 6-CF3-5-OEt-2-Py], [0812: 3-CN-5-OEt-2-Py], [0813: 4-CN-5-OEt-2 -Py], [0814: 6-CN-5-OEt-2-Py], [0815: 3-OMe- -OEt-2-Py], [0816: 4-OMe-5-OEt-2-Py], [0817: 6-OMe-5-OEt-2-Py], [0818: 6-OEt-2-Py] ], [0819: 3-Cl-6-OEt-2-Py], [0820: 4-Cl-6-OEt-2-Py], [0821: 5-Cl-6-OEt-2-Py], [0822: 3-Me-6-OEt-2-Py], [0823: 4-Me-6-OEt-2-Py], [0824: 5-Me-6-OEt-2-Py], [0825 : 3-CF3-6-OEt-2-Py], [0826: 4-CF3-6-OEt-2-Py], [0827: 5-CF3-6-OEt-2-Py], [0828: 3 -CN-6-OEt-2-Py], [0829: 4-CN-6-OEt-2-Py] [0830: 5-CN-6-OEt-2-Py], [0831: 3-OMe-6-OEt-2-Py], [0832: 4-OMe-6-OEt-2-Py], [0833] : 5-OMe-6-OEt-2-Py], [0834: 3-OCH2CF3-2-Py], [0835: 4-Cl-3-OCH2CF3-2-Py], [0836: 5-Cl-3 -OCH2CF3-2-Py], [0837: 6-Cl-3-OCH2CF3-2-Py], [0838: 4-Me-3-OCH2CF3-2-Py], [0839: 5-Me-3-OCH2CF3 -2-Py], [0840: 6-Me-3-OCH2CF3-2-Py], [0841: 4-CF3-3-OCH2CF3-2-Py], [0842: 5-CF3-3-OCH2CF3-2 -Py ], [0843: 6-CF3-3-OCH2CF3-2-Py], [0844: 4-CN-3-OCH2CF3-2-Py], [0845: 5-CN-3-OCH2CF3-2-Py], [0846: 6-CN-3-OCH2CF3-2-Py], [0847: 4-OMe-3-OCH2CF3-2-Py], [0848: 5-OMe-3-OCH2CF3-2-Py], [0849 : 6-OMe-3-OCH2CF3-2-Py], [0850: 4-OCH2CF3-2-Py], [0851: 3-Cl-4-OCH2CF3-2-Py], [0852: 5-Cl-4 -OCH2CF3-2-Py], [0853: 6-Cl-4-OCH2CF3-2-Py], [0854: 3-Me-4-OCH2CF3-2-Py], [0855: 5- e-4-OCH2CF3-2-Py], [0856: 6-Me-4-OCH2CF3-2-Py], [0857: 3-CF3-4-OCH2CF3-2-Py], [0858: 5-CF3- 4-OCH2CF3-2-Py], [0859: 6-CF3-4-OCH2CF3-2-Py], [0860: 3-CN-4-OCH2CF3-2-Py], [0861: 5-CN-4- OCH2CF3-2-Py], [0862: 6-CN-4-OCH2CF3-2-Py], [0863: 3-OMe-4-OCH2CF3-2-Py], [0864: 5-OMe-4-OCH2CF3- 2-Py], [0865: 6-OMe-4-OCH2CF3-2-Py], [0866: 5-OCH2CF3-2-Py], [0867: 3-Cl-5-OCH CF3-2-Py], [0868: 4-Cl-5-OCH2CF3-2-Py], [0869: 6-Cl-5-OCH2CF3-2-Py], [0870: 3-Me-5-OCH2CF3- 2-Py], [0871: 4-Me-5-OCH2CF3-2-Py], [0872: 6-Me-5-OCH2CF3-2-Py], [0873: 3-CF3-5-OCH2CF3-2- Py], [0874: 4-CF3-5-OCH2CF3-2-Py], [0875: 6-CF3-5-OCH2CF3-2-Py], [0876: 3-CN-5-OCH2CF3-2-Py] [0877: 4-CN-5-OCH2CF3-2-Py], [0878: 6-CN-5-OCH2CF3-2-Py], [0879: 3-OMe-5-OCH2CF3-2 -Py], [0880: 4-OMe-5-OCH2CF3-2-Py], [0881: 6-OMe-5-OCH2CF3-2-Py], [0882: 6-OCH2CF3-2-Py], [0883 : 3-Cl-6-OCH2CF3-2-Py], [0884: 4-Cl-6-OCH2CF3-2-Py], [0885: 5-Cl-6-OCH2CF3-2-Py], [0886: 3 -Me-6-OCH2CF3-2-Py], [0887: 4-Me-6-OCH2CF3-2-Py], [0888: 5-Me-6-OCH2CF3-2-Py], [0889: 3-CF3 -6-OCH2CF3-2-Py], [0890: 4-CF3-6-OCH2CF3-2-Py], [0891: 5-CF3-6-OCH2CF3-2-Py], [089] : 3-CN-6-OCH2CF3-2-Py], [0893: 4-CN-6-OCH2CF3-2-Py], [0894: 5-CN-6-OCH2CF3-2-Py], [0895: 3 -OMe-6-OCH2CF3-2-Py], [0896: 4-OMe-6-OCH2CF3-2-Py], [0897: 5-OMe-6-OCH2CF3-2-Py], [0898: 3-Pr -2-Py], [0899: 4-Cl-3-Pr-2-Py], [0900: 5-Cl-3-Pr-2-Py],

[0901: 6-Cl-3-Pr-2-Py], [0902: 4-Me-3-Pr-2-Py], [0903: 5-Me-3-Pr-2-Py], [0904] : 6-Me-3-Pr-2-Py], [0905: 4-CF3-3-Pr-2-Py], [0906: 5-CF3-3-Pr-2-Py], [0907: 6 -CF3-3-Pr-2-Py], [0908: 4-CN-3-Pr-2-Py], [0909: 5-CN-3-Pr-2-Py], [0910: 6-CN -3-Pr-2-Py], [0911: 4-OMe-3-Pr-2-Py], [0912: 5-OMe-3-Pr-2-Py], [0913: 6-OMe-3 -Pr-2-Py], [0914: 4-Pr-2-Py], [0915: 3-Cl-4-Pr-2-Py], [0 16: 5-Cl-4-Pr-2-Py], [0917: 6-Cl-4-Pr-2-Py], [0918: 3-Me-4-Pr-2-Py], [0919: 5-Me-4-Pr-2-Py], [0920: 6-Me-4-Pr-2-Py], [0921: 3-CF3-4-Pr-2-Py], [0922: 5- CF3-4-Pr-2-Py], [0923: 6-CF3-4-Pr-2-Py], [0924: 3-CN-4-Pr-2-Py], [0925: 5-CN- 4-Pr-2-Py], [0926: 6-CN-4-Pr-2-Py], [0927: 3-OMe-4-Pr-2-Py], [0928: 5-OMe-4- Pr-2-Py], [0929: 6-OMe-4-Pr-2-Py], [0930: 5-Pr-2-Py], [093 : 3-Cl-5-Pr-2-Py], [0932: 4-Cl-5-Pr-2-Py], [0933: 6-Cl-5-Pr-2-Py], [0934: 3 -Me-5-Pr-2-Py], [0935: 4-Me-5-Pr-2-Py], [0936: 6-Me-5-Pr-2-Py], [0937: 3-CF3 -5-Pr-2-Py], [0938: 4-CF3-5-Pr-2-Py], [0939: 6-CF3-5-Pr-2-Py], [0940: 3-CN-5. -Pr-2-Py], [0941: 4-CN-5-Pr-2-Py], [0942: 6-CN-5-Pr-2-Py], [0943: 3-OMe-5-Pr -2-Py], [0944: 4-OMe-5-Pr-2-Py], [0945: 6-OMe-5-Pr-2-Py], [0 946: 6-Pr-2-Py], [0947: 3-Cl-6-Pr-2-Py], [0948: 4-Cl-6-Pr-2-Py], [0949: 5-Cl- 6-Pr-2-Py], [0950: 3-Me-6-Pr-2-Py], [0951: 4-Me-6-Pr-2-Py], [0952: 5-Me-6-6 Pr-2-Py], [0953: 3-CF3-6-Pr-2-Py], [0954: 4-CF3-6-Pr-2-Py], [0955: 5-CF3-6-Pr- 2-Py], [0956: 3-CN-6-Pr-2-Py], [0957: 4-CN-6-Pr-2-Py], [0958: 5-CN-6-Pr-2- Py], [0959: 3-OMe-6-Pr-2-Py], [0960: 4-OMe-6-Pr-2-Py], [0961 5-OMe-6-Pr-2-Py], [0962: 3-OPr-2-Py], [0963: 4-Cl-3-OPr-2-Py], [0964: 5-Cl-3- OPr-2-Py], [0965: 6-Cl-3-OPr-2-Py], [0966: 4-Me-3-OPr-2-Py], [0967: 5-Me-3-OPr- 2-Py], [0968: 6-Me-3-OPr-2-Py], [0969: 4-CF3-3-OPr-2-Py], [0970: 5-CF3-3-OPr-2- Py], [0971: 6-CF3-3-OPr-2-Py], [0972: 4-CN-3-OPr-2-Py], [0973: 5-CN-3-OPr-2-Py] [0974: 6-CN-3-OPr-2-Py], [0975: 4-OMe-3-OPr- -Py], [0976: 5-OMe-3-OPr-2-Py], [0977: 6-OMe-3-OPr-2-Py], [0978: 4-OPr-2-Py], [0979] : 3-Cl-4-OPr-2-Py], [0980: 5-Cl-4-OPr-2-Py], [0981: 6-Cl-4-OPr-2-Py], [0982: 3 -Me-4-OPr-2-Py], [0983: 5-Me-4-OPr-2-Py], [0984: 6-Me-4-OPr-2-Py], [0985: 3-CF3 -4-OPr-2-Py], [0986: 5-CF3-4-OPr-2-Py], [0987: 6-CF3-4-OPr-2-Py], [0988: 3-CN-4 -OPr-2-Py], [0989: 5-CN-4-OPr-2-Py], [0990: 6-CN-4-OPr-2-Py], [0991: 3-OMe-4-OPr-2-Py], [0992: 5-OMe-4-OPr-2-Py], [0993: 6- OMe-4-OPr-2-Py], [0994: 5-OPr-2-Py], [0995: 3-Cl-5-OPr-2-Py], [0996: 4-Cl-5-OPr- 2-Py], [0997: 6-Cl-5-OPr-2-Py], [0998: 3-Me-5-OPr-2-Py], [0999: 4-Me-5-OPr-2- Py], [1000: 6-Me-5-OPr-2-Py],

[1001: 3-CF3-5-OPr-2-Py], [1002: 4-CF3-5-OPr-2-Py], [1003: 6-CF3-5-OPr-2-Py], [1004 : 3-CN-5-OPr-2-Py], [1005: 4-CN-5-OPr-2-Py], [1006: 6-CN-5-OPr-2-Py], [1007: 3 -OMe-5-OPr-2-Py], [1008: 4-OMe-5-OPr-2-Py], [1009: 6-OMe-5-OPr-2-Py], [1010: 6-OPr -2-Py], [1011: 3-Cl-6-OPr-2-Py], [1012: 4-Cl-6-OPr-2-Py], [1013: 5-Cl-6-OPr-2 -Py], [1014: 3-Me-6-OPr-2-Py], [1015: 4-Me 6-OPr-2-Py], [1016: 5-Me-6-OPr-2-Py], [1017: 3-CF3-6-OPr-2-Py], [1018: 4-CF3-6 OPr-2-Py], [1019: 5-CF3-6-OPr-2-Py], [1020: 3-CN-6-OPr-2-Py], [1021: 4-CN-6-OPr- 2-Py], [1022: 5-CN-6-OPr-2-Py], [1023: 3-OMe-6-OPr-2-Py], [1024: 4-OMe-6-OPr-2- Py], [1025: 5-OMe-6-OPr-2-Py], [1026: 3-SMe-2-Py], [1027: 4-Cl-3-SMe-2-Py], [1028: 5-Cl-3-SMe-2-Py], [1029: 6-Cl-3-SMe-2-P ], [1030: 4-Me-3-SMe-2-Py], [1031: 5-Me-3-SMe-2-Py], [1032: 6-Me-3-SMe-2-Py], [1033: 4-CF3-3-3-SMe-2-Py], [1034: 5-CF3-3-SMe-2-Py], [1035: 6-CF3-3-SMe-2-Py], [1036 : 4-CN-3-SMe-2-Py], [1037: 5-CN-3-SMe-2-Py], [1038: 6-CN-3-SMe-2-Py], [1039: 4 -OMe-3-SMe-2-Py], [1040: 5-OMe-3-SMe-2-Py], [1041: 6-OMe-3-SMe-2-Py], [1042: 4-SMe -2-Py], [1043: 3-Cl-4-SMe-2-Py], [1044: 5- Cl-4-SMe-2-Py], [1045: 6-Cl-4-SMe-2-Py], [1046: 3-Me-4-SMe-2-Py], [1047: 5-Me- 4-SMe-2-Py], [1048: 6-Me-4-SMe-2-Py], [1049: 3-CF3-4-SMe-2-Py], [1050: 5-CF3-4- SMe-2-Py], [1051: 6-CF3-4-SMe-2-Py], [1052: 3-CN-4-SMe-2-Py], [1053: 5-CN-4-SMe- 2-Py], [1054: 6-CN-4-SMe-2-Py], [1055: 3-OMe-4-SMe-2-Py], [1056: 5-OMe-4-SMe-2- Py], [1057: 6-OMe-4-SMe-2-Py], [1058: 5-SMe-2 Py], [1059: 3-Cl-5-SMe-2-Py], [1060: 4-Cl-5-SMe-2-Py], [1061: 6-Cl-5-SMe-2-Py] [1062: 3-Me-5-SMe-2-Py], [1063: 4-Me-5-SMe-2-Py], [1064: 6-Me-5-SMe-2-Py], [ 1065: 3-CF3-5-SMe-2-Py], [1066: 4-CF3-5-SMe-2-Py], [1067: 6-CF3-5-SMe-2-Py], [1068: 3-CN-5-SMe-2-Py], [1069: 4-CN-5-SMe-2-Py], [1070: 6-CN-5-SMe-2-Py], [1071: 3- OMe-5-SMe-2-Py], [1072: 4-OMe-5-SMe-2-Py], [ 073: 6-OMe-5-SMe-2-Py], [1074: 6-SMe-2-Py], [1075: 3-Cl-6-SMe-2-Py], [1076: 4-Cl- 6-SMe-2-Py], [1077: 5-Cl-6-SMe-2-Py], [1078: 3-Me-6-SMe-2-Py], [1079: 4-Me-6-6 SMe-2-Py], [1080: 5-Me-6-SMe-2-Py], [1081: 3-CF3-6-SMe-2-Py], [1082: 4-CF3-6-SMe- 2-Py], [1083: 5-CF3-6-SMe-2-Py], [1084: 3-CN-6-SMe-2-Py], [1085: 4-CN-6-SMe-2- Py], [1086: 5-CN-6-SMe-2-Py], [1087: 3-OMe-6-6 SMe-2-Py], [1088: 4-OMe-6-SMe-2-Py], [1089: 5-OMe-6-SMe-2-Py], [1090: 3-SCF3-2-Py] [1091: 4-Cl-3-SCF3-2-Py], [1092: 5-Cl-3-SCF3-2-Py], [1093: 6-Cl-3-SCF3-2-Py], [ 1094: 4-Me-3-SCF3-2-Py], [1095: 5-Me-3-SCF3-2-Py], [1096: 6-Me-3-SCF3-2-Py], [1097: 4-CF3-3-SCF3-2-Py], [1098: 5-CF3-3-SCF3-2-Py], [1099: 6-CF3-3-SCF3-2-Py], [1100: 4- CN-3-SCF3-2-Py],

[1101: 5-CN-3-SCF3-2-Py], [1102: 6-CN-3-SCF3-2-Py], [1103: 4-OMe-3-SCF3-2-Py], [1104 : 5-OMe-3-SCF3-2-Py], [1105: 6-OMe-3-SCF3-2-Py], [1106: 4-SCF3-2-Py], [1107: 3-Cl-4 -SCF3-2-Py], [1108: 5-Cl-4-SCF3-2-Py], [1109: 6-Cl-4-SCF3-2-Py], [1110: 3-Me-4-SCF3 -2-Py], [1111: 5-Me-4-SCF3-2-Py], [1112: 6-Me-4-SCF3-2-Py], [1113: 3-CF3-4-SCF3-2 -Py], [1114: 5-CF3-4-SCF3-2-P ], [1115: 6-CF3-4-SCF3-2-Py], [1116: 3-CN-4-SCF3-2-Py], [1117: 5-CN-4-SCF3-2-Py], [1118: 6-CN-4-SCF3-2-Py], [1119: 3-OMe-4-SCF3-2-Py], [1120: 5-OMe-4-SCF3-2-Py], [1121 : 6-OMe-4-SCF3-2-Py], [1122: 5-SCF3-2-Py], [1123: 3-Cl-5-SCF3-2-Py], [1124: 4-Cl-5 -SCF3-2-Py], [1125: 6-Cl-5-SCF3-2-Py], [1126: 3-Me-5-SCF3-2-Py], [1127: 4-Me-5-SCF3 -2-Py], [1128: 6-Me-5-SCF3-2 Py], [1129: 3-CF3-5-SCF3-2-Py], [1130: 4-CF3-5-SCF3-2-Py], [1131: 6-CF3-5-SCF3-2-Py] [1132: 3-CN-5-SCF3-2-Py], [1133: 4-CN-5-SCF3-2-Py], [1134: 6-CN-5-SCF3-2-Py], [ 1135: 3-OMe-5-SCF3-2-Py], [1136: 4-OMe-5-SCF3-2-Py], [1137: 6-OMe-5-SCF3-2-Py], [1138: 6-SCF3-2-Py], [1139: 3-Cl-6-SCF3-2-Py], [1140: 4-Cl-6-SCF3-2-Py], [1141: 6-Cl-6 SCF3-2-Py], [1142: 3-Me-6-SCF 3-2-Py], [1143: 4-Me-6-SCF3-2-Py], [1144: 6-Me-6-SCF3-2-Py], [1145: 3-CF3-6-SCF3- 2-Py], [1146: 4-CF3-6-SCF3-2-Py], [1147: 6-CF3-6-SCF3-2-Py], [1148: 3-CN-6-SCF3-2- Py], [1149: 4-CN-6-SCF3-2-Py], [1150: 6-CN-6-SCF3-2-Py], [1151: 3-OMe-6-SCF3-2-Py] [1152: 4-OMe-6-SCF3-2-Py], [1153: 6-OMe-6-SCF3-2-Py], [1154: 3-S (O) Me-2-Py], [ 1155: 4-Cl-3-S (O) Me-2-Py], [1156: 5- l-3-S (O) Me-2-Py], [1157: 6-Cl-3-S (O) Me-2-Py], [1158: 4-Me-3-S (O) Me- 2-Py], [1159: 5-Me-3-S (O) Me-2-Py], [1160: 6-Me-3-S (O) Me-2-Py], [1161: 4- CF3-3-S (O) Me-2-Py], [1162: 5-CF3-3-S (O) Me-2-Py], [1163: 6-CF3-3-S (O) Me- 2-Py], [1164: 4-CN-3-S (O) Me-2-Py], [1165: 5-CN-3-S (O) Me-2-Py], [1166: 6- CN-3-S (O) Me-2-Py], [1167: 4-OMe-3-S (O) Me-2-Py], [1168: 5-OMe-3-S (O) Me- 2-Py [1169: 6-OMe-3-S (O) Me-2-Py], [1170: 4-S (O) Me-2-Py], [1171: 3-Cl-4-S (O) Me-2-Py], [1172: 5-Cl-4-S (O) Me-2-Py], [1173: 6-Cl-4-S (O) Me-2-Py], [1174: 3-Me-4-S (O) Me-2-Py], [1175: 5-Me-4-S (O) Me-2-Py], [1176: 6-Me-4-S (O) Me-2-Py], [1177: 3-CF3-4-S (O) Me-2-Py], [1178: 5-CF3-4-S (O) Me-2-Py], [1179: 6-CF3-4-S (O) Me-2-Py], [1180: 3-CN-4-S (O) Me-2-Py], [1181: 5-CN-4-S (O) Me-2 -Py], [1182: 6-CN-4-S (O) Me-2-Py], [1183: 3-OMe-4-S (O) Me-2-Py], [1184: 5-OMe. -4-S (O) Me-2-Py], [1185: 6-OMe-4-S (O) Me-2-Py], [1186: 5-S (O) Me-2-Py], [1187: 3-Cl-5-S (O) Me-2-Py], [1188: 4-Cl-5-S (O) Me-2-Py], [1189: 6-Cl-5-S (O) Me-2-Py], [1190: 3-Me-5-S (O) Me-2-Py], [1191: 4-Me-5-S (O) Me-2-Py], [1192: 6-Me-5-S (O) Me-2-Py], [1193: 3-CF3-5-S (O) Me-2-Py], [1194: 4-CF3-5-S (O Me-2-Py], [1195: 6-CF3-5-S (O) Me-2-Py], [1196: 3-CN-5-S (O) Me-2-Py], [1197: 4-CN-5-S (O) Me-2-Py], [1198: 6-CN-5-S (O) Me-2-Py], [1199: 3-OMe-5-S (O) Me-2-Py], [1200: 4-OMe-5-S (O) Me-2-Py],

[1201: 6-OMe-5-S (O) Me-2-Py], [1202: 6-S (O) Me-2-Py], [1203: 3-Cl-6-S (O) Me -2-Py], [1204: 4-Cl-6-S (O) Me-2-Py], [1205: 5-Cl-6-S (O) Me-2-Py], [1206: 3 -Me-6-S (O) Me-2-Py], [1207: 4-Me-6-S (O) Me-2-Py], [1208: 5-Me-6-S (O) Me -2-Py], [1209: 3-CF3-6-S (O) Me-2-Py], [1210: 4-CF3-6-S (O) Me-2-Py], [1211: 5 -CF3-6-S (O) Me-2-Py], [1212: 3-CN-6-S (O) Me-2-Py], [1213: 4-CN-6-S (O) Me -2- y], [1214: 5-CN-6-S (O) Me-2-Py], [1215: 3-OMe-6-S (O) Me-2-Py], [1216: 4-OMe- 6-S (O) Me-2-Py], [1217: 5-OMe-6-S (O) Me-2-Py], [1218: 3-S (O) CF3-2-Py], [ 1219: 4-Cl-3-S (O) CF3-2-Py], [1220: 5-Cl-3-S (O) CF3-2-Py], [1221: 6-Cl-3-S ( O) CF3-2-Py], [1222: 4-Me-3-S (O) CF3-2-Py], [1223: 5-Me-3-S (O) CF3-2-Py], [ 1224: 6-Me-3-S (O) CF3-2-Py], [1225: 4-CF3-3-S (O) CF3-2-Py], [1226: 5-CF -3-S (O) CF3-2-Py], [1227: 6-CF3-3-S (O) CF3-2-Py], [1228: 4-CN-3-S (O) CF3-2 -Py], [1229: 5-CN-3-S (O) CF3-2-Py], [1230: 6-CN-3-S (O) CF3-2-Py], [1231: 4-OMe -3-S (O) CF3-2-Py], [1232: 5-OMe-3-S (O) CF3-2-Py], [1233: 6-OMe-3-S (O) CF3-2 -Py], [1234: 4-S (O) CF3-2-Py], [1235: 3-Cl-4-S (O) CF3-2-Py], [1236: 5-Cl-4-S (O) CF3-2-Py], [1237: 6-Cl-4-S (O) CF3-2-Py], [1238: 3-Me-4-S (O) CF3 -2-Py], [1239: 5-Me-4-S (O) CF3-2-Py], [1240: 6-Me-4-S (O) CF3-2-Py], [1241: 3 -CF3-4-S (O) CF3-2-Py], [1242: 5-CF3-4-S (O) CF3-2-Py], [1243: 6-CF3-4-S (O) CF3 -2-Py], [1244: 3-CN-4-S (O) CF3-2-Py], [1245: 5-CN-4-S (O) CF3-2-Py], [1246: 6 -CN-4-S (O) CF3-2-Py], [1247: 3-OMe-4-S (O) CF3-2-Py], [1248: 5-OMe-4-S (O) CF3 -2-Py], [1249: 6-OMe-4-S (O) CF3-2-Py], [1250: 5-S (O) CF3-2-Py], [ 251: 3-Cl-5-S (O) CF3-2-Py], [1252: 4-Cl-5-S (O) CF3-2-Py], [1253: 6-Cl-5-S ( O) CF3-2-Py], [1254: 3-Me-5-S (O) CF3-2-Py], [1255: 4-Me-5-S (O) CF3-2-Py], [ 1256: 6-Me-5-S (O) CF3-2-Py], [1257: 3-CF3-5-S (O) CF3-2-Py], [1258: 4-CF3-5-S ( O) CF3-2-Py], [1259: 6-CF3-5-S (O) CF3-2-Py], [1260: 3-CN-5-S (O) CF3-2-Py], [ 1261: 4-CN-5-S (O) CF3-2-Py], [1262: 6-CN-5-S (O) CF3-2-Py], [1263: 3 OMe-5-S (O) CF3-2-Py], [1264: 4-OMe-5-S (O) CF3-2-Py], [1265: 6-OMe-5-S (O) CF3- 2-Py], [1266: 6-S (O) CF3-2-Py], [1267: 3-Cl-6-S (O) CF3-2-Py], [1268: 4-Cl-6- S (O) CF3-2-Py], [1269: 5-Cl-6-S (O) CF3-2-Py], [1270: 3-Me-6-S (O) CF3-2-Py] [1271: 4-Me-6-S (O) CF3-2-Py], [1272: 5-Me-6-S (O) CF3-2-Py], [1273: 3-CF3-6 S (O) CF3-2-Py], [1274: 4-CF3-6-S (O) CF3-2-Py], [1275: 5-CF3-6-S (O ) CF3-2-Py], [1276: 3-CN-6-S (O) CF3-2-Py], [1277: 4-CN-6-S (O) CF3-2-Py], [1278 : 5-CN-6-S (O) CF3-2-Py], [1279: 3-OMe-6-S (O) CF3-2-Py], [1280: 4-OMe-6-S (O ) CF3-2-Py], [1281: 5-OMe-6-S (O) CF3-2-Py], [1282: 3-S (O) 2Me-2-Py], [1283: 4-Cl -3-S (O) 2Me-2-Py], [1284: 5-Cl-3-S (O) 2Me-2-Py], [1285: 6-Cl-3-S (O) 2Me-2 -Py], [1286: 4-Me-3-S (O) 2Me-2-Py], [1287: 5-Me-3-S (O) 2Me-2-Py], 1288: 6-Me-3-S (O) 2Me-2-Py], [1289: 4-CF3-3-S (O) 2Me-2-Py], [1290: 5-CF3-3-S ( O) 2Me-2-Py], [1291: 6-CF3-3-3-S (O) 2Me-2-Py], [1292: 4-CN-3-S (O) 2Me-2-Py], [ 1293: 5-CN-3-S (O) 2Me-2-Py], [1294: 6-CN-3-S (O) 2Me-2-Py], [1295: 4-OMe-3-S ( O) 2Me-2-Py], [1296: 5-OMe-3-S (O) 2Me-2-Py], [1297: 6-OMe-3-S (O) 2Me-2-Py], [ 1298: 4-S (O) 2Me-2-Py], [1299: 3-Cl-4-S (O) 2Me-2-Py], [1300: 5- l-4-S (O) 2Me-2-Py],

[1301: 6-Cl-4-S (O) 2Me-2-Py], [1302: 3-Me-4-S (O) 2Me-2-Py], [1303: 5-Me-4-S (O) 2Me-2-Py], [1304: 6-Me-4-S (O) 2Me-2-Py], [1305: 3-CF3-4-S (O) 2Me-2-Py], [1306: 5-CF3-4-S (O) 2Me-2-Py], [1307: 6-CF3-4-S (O) 2Me-2-Py], [1308: 3-CN-4-S (O) 2Me-2-Py], [1309: 5-CN-4-S (O) 2Me-2-Py], [1310: 6-CN-4-S (O) 2Me-2-Py], [1311: 3-OMe-4-S (O) 2Me-2-Py], [1312: 5-OMe-4-S (O) 2Me-2-Py], [131 : 6-OMe-4-S (O) 2Me-2-Py], [1314: 5-S (O) 2Me-2-Py], [1315: 3-Cl-5-S (O) 2Me-2 -Py], [1316: 4-Cl-5-S (O) 2Me-2-Py], [1317: 6-Cl-5-S (O) 2Me-2-Py], [1318: 3-Me -5-S (O) 2Me-2-Py], [1319: 4-Me-5-S (O) 2Me-2-Py], [1320: 6-Me-5-S (O) 2Me-2. -Py], [1321: 3-CF3-5-S (O) 2Me-2-Py], [1322: 4-CF3-5-S (O) 2Me-2-Py], [1323: 6-CF3 -5-S (O) 2Me-2-Py], [1324: 3-CN-5-S (O) 2Me-2-Py], [1325: 4-CN-5-S. O) 2Me-2-Py], [1326: 6-CN-5-S (O) 2Me-2-Py], [1327: 3-OMe-5-S (O) 2Me-2-Py], [ 1328: 4-OMe-5-S (O) 2Me-2-Py], [1329: 6-OMe-5-S (O) 2Me-2-Py], [1330: 6-S (O) 2Me- 2-Py], [1331: 3-Cl-6-S (O) 2Me-2-Py], [1332: 4-Cl-6-S (O) 2Me-2-Py], [1333: 5- Cl-6-S (O) 2Me-2-Py], [1334: 3-Me-6-S (O) 2Me-2-Py], [1335: 4-Me-6-S (O) 2Me- 2-Py], [1336: 5-Me-6-S (O) 2Me-2-Py], [1337: 3-CF3-6-S (O) 2Me-2-Py ], [1338: 4-CF3-6-S (O) 2Me-2-Py], [1339: 5-CF3-6-S (O) 2Me-2-Py], [1340: 3-CN-6 -S (O) 2Me-2-Py], [1341: 4-CN-6-S (O) 2Me-2-Py], [1342: 5-CN-6-S (O) 2Me-2-Py ], [1343: 3-OMe-6-S (O) 2Me-2-Py], [1344: 4-OMe-6-S (O) 2Me-2-Py], [1345: 5-OMe-6 -S (O) 2Me-2-Py], [1346: 3-S (O) 2CF3-2-Py], [1347: 4-Cl-3-S (O) 2CF3-2-Py], [1348 : 5-Cl-3-S (O) 2CF3-2-Py], [1349: 6-Cl-3-S (O) 2CF3-2-Py], [13 0: 4-Me-3-S (O) 2CF3-2-Py], [1351: 5-Me-3-S (O) 2CF3-2-Py], [1352: 6-Me-3-S ( O) 2CF3-2-Py], [1353: 4-CF3-3-S (O) 2CF3-2-Py], [1354: 5-CF3-3-S (O) 2CF3-2-Py], [ 1355: 6-CF3-3-S (O) 2CF3-2-Py], [1356: 4-CN-3-S (O) 2CF3-2-Py], [1357: 5-CN-3-S ( O) 2CF3-2-Py], [1358: 6-CN-3-S (O) 2CF3-2-Py], [1359: 4-OMe-3-S (O) 2CF3-2-Py], [ 1360: 5-OMe-3-S (O) 2CF3-2-Py], [1361: 6-OMe-3-S (O) 2CF3- -Py], [1362: 4-S (O) 2CF3-2-Py], [1363: 3-Cl-4-S (O) 2CF3-2-Py], [1364: 5-Cl-4-S. (O) 2CF3-2-Py], [1365: 6-Cl-4-S (O) 2CF3-2-Py], [1366: 3-Me-4-S (O) 2CF3-2-Py], [1367: 5-Me-4-S (O) 2CF3-2-Py], [1368: 6-Me-4-S (O) 2CF3-2-Py], [1369: 3-CF3-4-S (O) 2CF3-2-Py], [1370: 5-CF3-4-S (O) 2CF3-2-Py], [1371: 6-CF3-4-S (O) 2CF3-2-Py], [1372: 3-CN-4-S (O) 2CF3-2-Py], [1373: 5-CN-4-S (O) 2CF3- 2-Py], [1374: 6-CN-4-S (O) 2CF3-2-Py], [1375: 3-OMe-4-S (O) 2CF3-2-Py], [1376: 5- OMe-4-S (O) 2CF3-2-Py], [1377: 6-OMe-4-S (O) 2CF3-2-Py], [1378: 5-S (O) 2CF3-2-Py] [1379: 3-Cl-5-S (O) 2CF3-2-Py], [1380: 4-Cl-5-S (O) 2CF3-2-Py], [1381: 6-Cl-5- S (O) 2CF3-2-Py], [1382: 3-Me-5-S (O) 2CF3-2-Py], [1383: 4-Me-5-S (O) 2CF3-2-Py] [1384: 6-Me-5-S (O) 2CF3-2-Py], [1385: 3-CF3-5-S (O) 2CF -2-Py], [1386: 4-CF3-5-S (O) 2CF3-2-Py], [1387: 6-CF3-5-S (O) 2CF3-2-Py], [1388: 3 -CN-5-S (O) 2CF3-2-Py], [1389: 4-CN-5-S (O) 2CF3-2-Py], [1390: 6-CN-5-S (O) 2CF3 -2-Py], [1391: 3-OMe-5-S (O) 2CF3-2-Py], [1392: 4-OMe-5-S (O) 2CF3-2-Py], [1393: 6 -OMe-5-S (O) 2CF3-2-Py], [1394: 6-S (O) 2CF3-2-Py], [1395: 3-Cl-6-S (O) 2CF3-2-Py ], [1396: 4-Cl-6-S (O) 2CF3-2-Py], [1397: 5-Cl-6-S (O) CF3-2-Py], [1398: 3-Me-6-S (O) 2CF3-2-Py], [1399: 4-Me-6-S (O) 2CF3-2-Py], [1400: 5-Me-6-S (O) 2CF3-2-Py],

[1401: 3-CF3-6-S (O) 2CF3-2-Py], [1402: 4-CF3-6-S (O) 2CF3-2-Py], [1403: 5-CF3-6-S (O) 2CF3-2-Py], [1404: 3-CN-6-S (O) 2CF3-2-Py], [1405: 4-CN-6-S (O) 2CF3-2-Py], [1406: 5-CN-6-S (O) 2CF3-2-Py], [1407: 3-OMe-6-S (O) 2CF3-2-Py], [1408: 4-OMe-6-S (O) 2CF3-2-Py], [1409: 5-OMe-6-S (O) 2CF3-2-Py], [1410: 3-CN-2-Py], [1411: 4-Cl-3 -CN-2-Py], [1412: 5-Cl-3-CN-2-Py], [1413: 6-Cl-3-C -2-Py], [1414: 4-Me-3-CN-2-Py], [1415: 5-Me-3-CN-2-Py], [1416: 6-Me-3-CN-2 -Py], [1417: 4-CF3-3-CN-2-Py], [1418: 5-CF3-3-CN-2-Py], [1419: 6-CF3-3-CN-2-Py] ], [1420: 4-CN-3-CN-2-Py], [1421: 5-CN-3-CN-2-Py], [1422: 6-CN-3-CN-2-Py], [1423: 4-OMe-3-CN-2-Py], [1424: 5-OMe-3-CN-2-Py], [1425: 6-OMe-3-CN-2-Py], [1426 : 4-CN-2-Py], [1427: 3-Cl-4-CN-2-Py], [1428: 5-Cl-4-CN- -Py], [1429: 6-Cl-4-CN-2-Py], [1430: 3-Me-4-CN-2-Py], [1431: 5-Me-4-CN-2-Py ], [1432: 6-Me-4-CN-2-Py], [1433: 3-CF3-4-CN-2-Py], [1434: 5-CF3-4-CN-2-Py], [1435: 6-CF3-4-CN-2-Py], [1436: 3-CN-4-CN-2-Py], [1437: 5-CN-4-CN-2-Py], [1438 : 6-CN-4-CN-2-Py], [1439: 3-OMe-4-CN-2-Py], [1440: 5-OMe-4-CN-2-Py], [1441: 6 -OMe-4-CN-2-Py], [1442: 5-CN-2-Py], [1443: 3-Cl-5-CN-2-P y], [1444: 4-Cl-5-CN-2-Py], [1445: 6-Cl-5-CN-2-Py], [1446: 3-Me-5-CN-2-Py] [1447: 4-Me-5-CN-2-Py], [1448: 6-Me-5-CN-2-Py], [1449: 3-CF3-5-CN-2-Py], [ 1450: 4-CF3-5-CN-2-Py], [1451: 6-CF3-5-CN-2-Py], [1452: 3-CN-5-CN-2-Py], [1453: 4-CN-5-CN-2-Py], [1454: 6-CN-5-CN-2-Py], [1455: 3-OMe-5-CN-2-Py], [1456: 4- OMe-5-CN-2-Py], [1457: 6-OMe-5-CN-2-Py], [1458: 6-CN-2-Py] [1458: 3-Cl-6-CN-2-Py], [1460: 4-Cl-6-CN-2-Py], [1461: 5-Cl-6-CN-2-Py], [1462 : 3-Me-6-CN-2-Py], [1463: 4-Me-6-CN-2-Py], [1464: 5-Me-6-CN-2-Py], [1465: 3 -CF3-6-CN-2-Py], [1466: 4-CF3-6-CN-2-Py], [1467: 5-CF3-6-CN-2-Py], [1468: 3-CN -6-CN-2-Py], [1469: 4-CN-6-CN-2-Py], [1470: 5-CN-6-CN-2-Py], [1471: 3-OMe-6 -CN-2-Py], [1472: 4-OMe-6-CN-2-Py], [1473: 5-OMe-6-CN-2- y], [1474: 3-COOMe-2-Py], [1475: 4-Cl-3-COOMe-2-Py], [1476: 5-Cl-3-COOMe-2-Py], [1477: 6-Cl-3-COOMe-2-Py], [1478: 4-Me-3-COOMe-2-Py], [1479: 5-Me-3-COOMe-2-Py], [1480: 6- Me-3-COOMe-2-Py], [1481: 4-CF3-3-COOMe-2-Py], [1482: 5-CF3-3-COOMe-2-Py], [1483: 6-CF3- 3-COOMe-2-Py], [1484: 4-CN-3-COOMe-2-Py], [1485: 5-CN-3-COOMe-2-Py], [1486: 6-CN-3- COOMe-2-Py], [1487: 4 -OMe-3-COOMe-2-Py], [1488: 5-OMe-3-COOMe-2-Py], [1489: 6-OMe-3-COOMe-2-Py], [1490: 4-COOMe -2-Py], [1491: 3-Cl-4-COOMe-2-Py], [1492: 5-Cl-4-COOMe-2-Py], [1493: 6-Cl-4-COOMe-2 -Py], [1494: 3-Me-4-COOMe-2-Py], [1495: 5-Me-4-COOMe-2-Py], [1496: 6-Me-4-COOMe-2-Py] ], [1497: 3-CF3-4-COOMe-2-Py], [1498: 5-CF3-4-COOMe-2-Py], [1499: 6-CF3-4-COOMe-2-Py], [1500: 3-CN-4-C OMe-2-Py],

[1501: 5-CN-4-COOMe-2-Py], [1502: 6-CN-4-COOMe-2-Py], [1503: 3-OMe-4-COOMe-2-Py], [1504 : 5-OMe-4-COOMe-2-Py], [1505: 6-OMe-4-COOMe-2-Py], [1506: 5-COOMe-2-Py], [1507: 3-Cl-5 -COOMe-2-Py], [1508: 4-Cl-5-COOMe-2-Py], [1509: 6-Cl-5-COOMe-2-Py], [1510: 3-Me-5-COOMe -2-Py], [1511: 4-Me-5-COOMe-2-Py], [1512: 6-Me-5-COOMe-2-Py], [1513: 3-CF3-5-COOMe-2 -Py], [1514: 4-C 3-5-COOMe-2-Py], [1515: 6-CF3-5-COOMe-2-Py], [1516: 3-CN-5-COOMe-2-Py], [1517: 4-CN- 5-COOMe-2-Py], [1518: 6-CN-5-COOMe-2-Py], [1519: 3-OMe-5-COOMe-2-Py], [1520: 4-OMe-5 COOMe-2-Py], [1521: 6-OMe-5-COOMe-2-Py], [1522: 6-COOMe-2-Py], [1523: 3-Cl-6-COOMe-2-Py] [1524: 4-Cl-6-COOMe-2-Py], [1525: 5-Cl-6-COOMe-2-Py], [1526: 3-Me-6-COOMe-2-Py], [ 1527: 4-Me-6-COOM -2-Py], [1528: 5-Me-6-COOMe-2-Py], [1529: 3-CF3-6-COOMe-2-Py], [1530: 4-CF3-6-COOMe-2 -Py], [1531: 5-CF3-6-COOMe-2-Py], [1532: 3-CN-6-COOMe-2-Py], [1533: 4-CN-6-COOMe-2-Py ], [1534: 5-CN-6-COOMe-2-Py], [1535: 3-OMe-6-COOMe-2-Py], [1536: 4-OMe-6-COOMe-2-Py], [1537: 5-OMe-6-COOMe-2-Py], [1538: 3-NO2-2-2-Py], [1539: 4-Cl-3-NO2-2-2-Py], [1540: 5-Cl -3-NO2-2Py], [1541: 6-Cl-3-NO2-2-Py], [1542: 4-Me-3-NO2-2-Py], [1543: 5-Me-3-NO2-2-Py], [1544: 6- Me-3-NO2-2-2-Py], [1545: 4-CF3-3-NO2-2-Py], [1546: 5-CF3-3-NO2-2-Py], [1547: 6-CF3- 3-NO2-2-2-Py], [1548: 4-CN-3-NO2-2-2-Py], [1549: 5-CN-3-NO2-2-Py], [1550: 6-CN-3- NO2-2-2-Py], [1551: 4-OMe-3-NO2-2-2-Py], [1552: 5-OMe-3-NO2-2-2-Py], [1553: 6-OMe-3-NO2- 2-Py], [1554: 4-NO2-2-Py], [1555: 3-Cl-4-NO2 2-Py], [1556: 5-Cl-4-NO2-2-Py], [1557: 6-Cl-4-NO2-2-Py], [1558: 3-Me-4-NO2-2- Py], [1559: 5-Me-4-NO2-2-Py], [1560: 6-Me-4-NO2-2-Py], [1561: 3-CF3-4-NO2-2-Py] [1562: 5-CF3-4-NO2-2-Py], [1563: 6-CF3-4-NO2-2-2-Py], [1564: 3-CN-4-NO2-2-Py], [ 1565: 5-CN-4-NO2-2-Py], [1566: 6-CN-4-NO2-2-Py], [1567: 3-OMe-4-NO2-2-Py], [1568: 5-OMe-4-NO2-2-Py], [1569: 6-OMe-4-NO2-2-2-Py [1570: 5-NO2-2-Py], [1571: 3-Cl-5-NO2-2-2-Py], [1572: 4-Cl-5-NO2-2-Py], [1573: 6- Cl-5-NO2-2-2-Py], [1574: 3-Me-5-NO2-2-2-Py], [1575: 4-Me-5-NO2-2-Py], [1576: 6-Me- 5-NO2-2-2-Py], [1577: 3-CF3-5-NO2-2-2-Py], [1578: 4-CF3-5-NO2-2-2-Py], [1579: 6-CF3-5 NO2-2-2-Py], [1580: 3-CN-5-NO2-2-2-Py], [1581: 4-CN-5-NO2-2-2-Py], [1582: 6-CN-5-NO2- 2-Py], [1583: 3-OMe-5-NO2-2-Py], [1584: 4-OMe -5-NO2-2-Py], [1585: 6-OMe-5-NO2-2-Py], [1586: 6-NO2-2-Py], [1587: 3-Cl-6-NO2-2 -Py], [1588: 4-Cl-6-NO2-2-Py], [1589: 5-Cl-6-NO2-2-Py], [1590: 3-Me-6-NO2-2-Py ], [1591: 4-Me-6-NO2-2-Py], [1592: 5-Me-6-NO2-2-Py], [1593: 3-CF3-6-NO2-2-Py], [1594: 4-CF3-6-NO2-2-Py], [1595: 5-CF3-6-NO2-2-Py], [1596: 3-CN-6-NO2-2-Py], [1597 : 4-CN-6-NO2-2-Py], [1598: 5-CN-6-NO2-2-Py] [1599: 3-OMe-6-NO2-2-Py], [1600: 4-OMe-6-NO2-2-Py],

[1601: 5-OMe-6-NO2-2-Py], [1602: 3-NH2-2-Py], [1603: 4-Cl-3-NH2-2-Py], [1604: 5-Cl -3-NH2-2-Py], [1605: 6-Cl-3-NH2-2-Py], [1606: 4-Me-3-NH2-2-Py], [1607: 5-Me-3 -NH2-2-Py], [1608: 6-Me-3-NH2-2-Py], [1609: 4-CF3-3-NH2-2-Py], [1610: 5-CF3-3-NH2 -2-Py], [1611: 6-CF3-3-NH2-2-Py], [1612: 4-CN-3-NH2-2-Py], [1613: 5-CN-3-NH2-2 -Py], [1614: 6-CN-3-NH2-2-Py], [1615: 4-OMe- -NH2-2-Py], [1616: 5-OMe-3-NH2-2-Py], [1617: 6-OMe-3-NH2-2-Py], [1618: 4-NH2-2-Py] ], [1619: 3-Cl-4-NH2-2-Py], [1620: 5-Cl-4-NH2-2-Py], [1621: 6-Cl-4-NH2-2-Py], [1622: 3-Me-4-NH2-2-Py], [1623: 5-Me-4-NH2-2-Py], [1624: 6-Me-4-NH2-2-Py], [1625 : 3-CF3-4-NH2-2-Py], [1626: 5-CF3-4-NH2-2-Py], [1627: 6-CF3-4-NH2-2-Py], [1628: 3 -CN-4-NH2-2-Py], [1629: 5-CN-4-NH2-2-Py] [1630: 6-CN-4-NH2-2-Py], [1631: 3-OMe-4-NH2-2-Py], [1632: 5-OMe-4-NH2-2-Py], [1633 : 6-OMe-4-NH2-2-Py], [1634: 5-NH2-2-Py], [1635: 3-Cl-5-NH2-2-Py], [1636: 4-Cl-5 -NH2-2-Py], [1637: 6-Cl-5-NH2-2-Py], [1638: 3-Me-5-NH2-2-Py], [1639: 4-Me-5-NH2 -2-Py], [1640: 6-Me-5-NH2-2-Py], [1641: 3-CF3-5-NH2-2-Py], [1642: 4-CF3-5-NH2-2 -Py], [1643: 6-CF3-5-NH2-2-Py], [1644: 3-CN -5-NH2-2-Py], [1645: 4-CN-5-NH2-2-Py], [1646: 6-CN-5-NH2-2-Py], [1647: 3-OMe-5 -NH2-2-Py], [1648: 4-OMe-5-NH2-2-Py], [1649: 6-OMe-5-NH2-2-Py], [1650: 6-NH2-2-Py] ], [1651: 3-Cl-6-NH2-2-Py], [1652: 4-Cl-6-NH2-2-Py], [1653: 5-Cl-6-NH2-2-Py], [1654: 3-Me-6-NH2-2-Py], [1655: 4-Me-6-NH2-2-Py], [1656: 5-Me-6-NH2-2-Py], [1657 : 3-CF3-6-NH2-2-Py], [1658: 4-CF3-6-NH2-2-Py [1659: 5-CF3-6-NH2-2-Py], [1660: 3-CN-6-NH2-2-Py], [1661: 4-CN-6-NH2-2-Py], [ 1662: 5-CN-6-NH2-2-Py], [1663: 3-OMe-6-NH2-2-Py], [1664: 4-OMe-6-NH2-2-Py], [1665: 5-OMe-6-NH2-2-Py], [1666: 3-NHMe-2-Py], [1667: 4-Cl-3-NHMe-2-Py], [1668: 5-Cl-3- NHMe-2-Py], [1669: 6-Cl-3-NHMe-2-Py], [1670: 4-Me-3-NHMe-2-Py], [1671: 5-Me-3-NHMe- 2-Py], [1672: 6-Me-3-NHMe-2-Py], [16 3: 4-CF3-3-NHMe-2-Py], [1674: 5-CF3-3-NHMe-2-Py], [1675: 6-CF3-3-NHMe-2-Py], [1676: 4-CN-3-NHMe-2-Py], [1679: 5-CN-3-NHMe-2-Py], [1678: 6-CN-3-NHMe-2-Py], [1679: 4- OMe-3-NHMe-2-Py], [1680: 5-OMe-3-NHMe-2-Py], [1681: 6-OMe-3-NHMe-2-Py], [1682: 4-NHMe- 2-Py], [1683: 3-Cl-4-NHMe-2-Py], [1684: 5-Cl-4-NHMe-2-Py], [1685: 6-Cl-4-NHMe-2- Py], [1686: 3-Me-4-NHMe-2-Py], [1687: 5-Me-4-NHMe-2-Py], [1688: 6-Me-4-NHMe-2-Py], [1689: 3-CF3-4-NHMe-2-Py], [1690 : 5-CF3-4-NHMe-2-Py], [1691: 6-CF3-4-NHMe-2-Py], [1692: 3-CN-4-NHMe-2-Py], [1693: 5 -CN-4-NHMe-2-Py], [1694: 6-CN-4-NHMe-2-Py], [1695: 3-OMe-4-NHMe-2-Py], [1696: 5-OMe -4-NHMe-2-Py], [1697: 6-OMe-4-NHMe-2-Py], [1698: 5-NHMe-2-Py], [1699: 3-Cl-5-NHMe-2 -Py], [1700: 4-Cl-5-NHMe-2- y],

[1701: 6-Cl-5-NHMe-2-Py], [1702: 3-Me-5-NHMe-2-Py], [1703: 4-Me-5-NHMe-2-Py], [1704 : 6-Me-5-NHMe-2-Py], [1705: 3-CF3-5-NHMe-2-Py], [1706: 4-CF3-5-NHMe-2-Py], [1707: 6 -CF3-5-NHMe-2-Py], [1708: 3-CN-5-NHMe-2-Py], [1709: 4-CN-5-NHMe-2-Py], [1710: 6-CN -5-NHMe-2-Py], [1711: 3-OMe-5-NHMe-2-Py], [1712: 4-OMe-5-NHMe-2-Py], [1713: 6-OMe-5 -NHMe-2-Py], [1714: 6-NHMe-2- y], [1715: 3-Cl-6-NHMe-2-Py], [1716: 4-Cl-6-NHMe-2-Py], [1717: 5-Cl-6-NHMe-2-Py] [1718: 3-Me-6-NHMe-2-Py], [1719: 4-Me-6-NHMe-2-Py], [1720: 5-Me-6-NHMe-2-Py], [ 1721: 3-CF3-6-NHMe-2-Py], [1722: 4-CF3-6-NHMe-2-Py], [1723: 5-CF3-6-NHMe-2-Py], [1724: 3-CN-6-NHMe-2-Py], [1725: 4-CN-6-NHMe-2-Py], [1726: 5-CN-6-NHMe-2-Py], [1727: 3- OMe-6-NHMe-2-Py], [1728: 4-OMe-6 NHMe-2-Py], [1729: 5-OMe-6-NHMe-2-Py], [1730: 3-NMe2-2-Py], [1731: 4-Cl-3-NMe2-2-Py] [1732: 5-Cl-3-NMe2-2-Py], [1733: 6-Cl-3-NMe2-2-Py], [1734: 4-Me-3-NMe2-2-Py], [ 1735: 5-Me-3-NMe2-2-Py], [1736: 6-Me-3-NMe2-2-Py], [1737: 4-CF3-3-NMe2-2-Py], [1738: 5-CF3-3-NMe2-2-Py], [1739: 6-CF3-3-NMe2-2-2-Py], [1740: 4-CN-3-NMe2-2-Py], [1741: 5- CN-3-NMe2-2-Py], [1742: 6-CN- 3-NMe2-2-Py], [1743: 4-OMe-3-NMe2-2-Py], [1744: 5-OMe-3-NMe2-2-Py], [1745: 6-OMe-3- NMe2-2-Py], [1746: 4-NMe2-2-Py], [1747: 3-Cl-4-NMe2-2-Py], [1748: 5-Cl-4-NMe2-2-Py] [1749: 6-Cl-4-NMe2-2-Py], [1750: 3-Me-4-NMe2-2-Py], [1751: 5-Me-4-NMe2-2-Py], [ 1752: 6-Me-4-NMe2-2-Py], [1753: 3-CF3-4-NMe2-2-Py], [1754: 5-CF3-4-NMe2-2-Py], [1755: 6-CF3-4-NMe2-2-Py], [1756: 3 CN-4-NMe2-2-Py], [1757: 5-CN-4-NMe2-2-Py], [1758: 6-CN-4-NMe2-2-Py], [1759: 3-OMe- 4-NMe2-2-Py], [1760: 5-OMe-4-NMe2-2-Py], [1761: 6-OMe-4-NMe2-2-Py], [1762: 5-NMe2-2- Py], [1763: 3-Cl-5-NMe2-2-Py], [1764: 4-Cl-5-NMe2-2-Py], [1765: 6-Cl-5-NMe2-2-Py] [1766: 3-Me-5-NMe2-2-Py], [1767: 4-Me-5-NMe2-2-Py], [1768: 6-Me-5-NMe2-2-Py], [ 1769: 3-CF3-5-NMe2-2-2-Py], [1770 4-CF3-5-NMe2-2-Py], [1771: 6-CF3-5-NMe2-2-2-Py], [1772: 3-CN-5-NMe2-2-Py], [1773: 4- CN-5-NMe2-2-Py], [1774: 6-CN-5-NMe2-2-2-Py], [1775: 3-OMe-5-NMe2-2-Py], [1776: 4-OMe- 5-NMe2-2-Py], [1777: 6-OMe-5-NMe2-2-2-Py], [1778: 6-NMe2-2-Py], [179: 3-Cl-6-NMe2-2 Py], [1780: 4-Cl-6-NMe2-2-Py], [1781: 5-Cl-6-NMe2-2-Py], [1782: 3-Me-6-NMe2-2-Py] [1783: 4-Me-6-NMe2-2-2-Py], [17 84: 5-Me-6-NMe2-2-Py], [1785: 3-CF3-6-NMe2-2-Py], [1786: 4-CF3-6-NMe2-2-Py], [1787: 5-CF3-6-NMe2-2-Py], [1788: 3-CN-6-NMe2-2-2-Py], [1789: 4-CN-6-NMe2-2-Py], [1790: 5- CN-6-NMe2-2Py], [1791: 3-OMe-6-NMe2-2Py], [1792: 4-OMe-6-NMe2-2Py], [1793: 5-OMe- 6-NMe2-2-Py], [1794: 3-ACNH-2-Py], [1795: 4-Cl-3-ACNH-2-Py], [1796: 5-Cl-3-ACNH-2- Py], [1797: 6-Cl-3-ACNH-2-Py] [1798: 4-Me-3-ACNH-2-Py], [1799: 5-Me-3-ACNH-2-Py], [1800: 6-Me-3-ACNH-2-Py],

[1801: 4-CF3-3-ACNH-2-Py], [1802: 5-CF3-3-ACNH-2-Py], [1803: 6-CF3-3-ACNH-2-Py], [1804 : 4-CN-3-ACNH-2-Py], [1805: 5-CN-3-ACNH-2-Py], [1806: 6-CN-3-ACNH-2-Py], [1807: 4 -OMe-3-ACNH-2-Py], [1808: 5-OMe-3-ACNH-2-Py], [1809: 6-OMe-3-ACNH-2-Py], [1810: 4-ACNH -2-Py], [1811: 3-Cl-4-ACNH-2-Py], [1812: 5-Cl-4-ACNH-2-Py], [1813: 6-Cl-4-ACNH-2 -Py], [1814: 3-Me-4-ACNH-2- y], [1815: 5-Me-4-ACNH-2-Py], [1816: 6-Me-4-ACNH-2-Py], [1817: 3-CF3-4-ACNH-2-Py] [1818: 5-CF3-4-ACNH-2-Py], [1819: 6-CF3-4-ACNH-2-Py], [1820: 3-CN-4-ACNH-2-Py], [ 1821: 5-CN-4-ACNH-2-Py], [1822: 6-CN-4-ACNH-2-Py], [1823: 3-OMe-4-ACNH-2-Py], [1824: 5-OMe-4-ACNH-2-Py], [1825: 6-OMe-4-ACNH-2-Py], [1826: 5-ACNH-2-Py], [1827: 3-Cl-5 ACNH-2-Py], [1828: 4-Cl-5-ACN -2-Py], [1829: 6-Cl-5-ACNH-2-Py], [1830: 3-Me-5-ACNH-2-Py], [1831: 4-Me-5-ACNH-2 -Py], [1832: 6-Me-5-ACNH-2-Py], [1833: 3-CF3-5-ACNH-2-Py], [1834: 4-CF3-5-ACNH-2-Py] ], [1835: 6-CF3-5-ACNH-2-Py], [1836: 3-CN-5-ACNH-2-Py], [1837: 4-CN-5-ACNH-2-Py], [1838: 6-CN-5-ACNH-2-Py], [1839: 3-OMe-5-ACNH-2-Py], [1840: 4-OMe-5-ACNH-2-Py], [1841 : 6-OMe-5-ACNH-2-Py], [1842: 6- ACNH-2-Py], [1843: 3-Cl-6-ACNH-2-Py], [1844: 4-Cl-6-ACNH-2-Py], [1845: 5-Cl-6-ACNH- 2-Py], [1846: 3-Me-6-ACNH-2-Py], [1847: 4-Me-6-ACNH-2-Py], [1848: 5-Me-6-ACNH-2- Py], [1849: 3-CF3-6-ACNH-2-Py], [1850: 4-CF3-6-ACNH-2-Py], [1851: 5-CF3-6-ACNH-2-Py] [1852: 3-CN-6-ACNH-2-Py], [1853: 4-CN-6-ACNH-2-Py], [1854: 5-CN-6-ACNH-2-Py], [ 1855: 3-OMe-6-ACNH-2-Py], [1856: -OMe-6-ACNH-2-Py], [1857: 5-OMe-6-ACNH-2-Py], [1858: 3- (N-AC-N-Me-N) -2-Py], [1859: 4-Cl-3- (N-AC-N-Me-N) -2-Py], [1860: 5-Cl-3- (N-AC-N-Me-N) -2-Py ], [1861: 6-Cl-3- (N-AC-N-Me-N) -2-Py], [1862: 4-Me-3- (N-AC-N-Me-N) -2 -Py], [1863: 5-Me-3- (N-AC-N-Me-N) -2-Py], [1864: 6-Me-3- (N-AC-N-Me-N) -2-Py], [1865: 4-CF3-3 (N-AC-N-Me-N) -2-Py], [1866: 5-CF3-3 (N-AC-N-Me-) N) -2 Py], [1867: 6-CF3-3 (N-AC-N-Me-N) -2-Py], [1868: 4-CN-3- (N-AC-N-Me-N)- 2-Py], [1869: 5-CN-3- (N-AC-N-Me-N) -2-Py], [1870: 6-CN-3- (N-AC-N-Me-N) ) -2-Py], [1871: 4-OMe-3- (N-AC-N-Me-N) -2-Py], [1872: 5-OMe-3- (N-AC-N-Me). -N) -2-Py], [1873: 6-OMe-3- (N-AC-N-Me-N) -2-Py], [1874: 4- (N-AC-N-Me-N). ) -2-Py], [1875: 3-Cl-4- (N-AC-N-Me-N) -2-Py], [1876: 5-Cl-4- (N-AC-N-Me). -N) -2-Py], [1877: 6-Cl-4- (N-AC-N-Me-N) -2-Py], [1878: 3-Me-4- (N-AC-N-Me-N) -2-Py ], [1879: 5-Me-4- (N-AC-N-Me-N) -2-Py], [1880: 6-Me-4- (N-AC-N-Me-N) -2. -Py], [1881: 3-CF3-4- (N-AC-N-Me-N) -2-Py], [1882: 5-CF3-4- (N-AC-N-Me-N) -2-Py], [1883: 6-CF3-4- (N-AC-N-Me-N) -2-Py], [1884: 3-CN-4- (N-AC-N-Me- N) -2-Py], [1885: 5-CN-4- (N-AC-N-Me-N) -2-Py], [1886: 6-CN-4- (N-AC-N- Me-N) -2-Py], 1887: 3-OMe-4- (N-AC-N-Me-N) -2-Py], [1888: 5-OMe-4- (N-AC-N-Me-N) -2-Py] [1889: 6-OMe-4- (N-AC-N-Me-N) -2-Py], [1890: 5- (N-AC-N-Me-N) -2-Py], [ 1891: 3-Cl-5- (N-AC-N-Me-N) -2-Py], [1892: 4-Cl-5- (N-AC-N-Me-N) -2-Py] [1893: 6-Cl-5- (N-AC-N-Me-N) -2-Py], [1894: 3-Me-5- (N-AC-N-Me-N) -2- Py], [1895: 4-Me-5- (N-AC-N-Me-N) -2-Py], [1896: 6-Me-5- (N-AC-N-Me-N)- 2-Py], [1897 3-CF3-5- (N-AC-N-Me-N) -2-Py], [1898: 4-CF3-5- (N-AC-N-Me-N) -2-Py], [ 1899: 6-CF3-5- (N-AC-N-Me-N) -2-Py], [1900: 3-CN-5- (N-AC-N-Me-N) -2-Py] ,

[1901: 4-CN-5- (N-AC-N-Me-N) -2-Py], [1902: 6-CN-5- (N-AC-N-Me-N) -2-Py ], [1903: 3-OMe-5- (N-AC-N-Me-N) -2-Py], [1904: 4-OMe-5- (N-AC-N-Me-N) -2 -Py], [1905: 6-OMe-5- (N-AC-N-Me-N) -2-Py], [1906: 6- (N-AC-N-Me-N) -2-Py ], [1907: 3-Cl-6- (N-AC-N-Me-N) -2-Py], [1908: 4-Cl-6- (N-AC-N-Me-N) -2. -Py], [1909: 5-Cl-6- (N-AC-N-Me-N) -2-Py], [1910: 3-Me-6- (N-AC-N-Me-N) -2-Py], [1911 4-Me-6- (N-AC-N-Me-N) -2-Py], [1912: 5-Me-6- (N-AC-N-Me-N) -2-Py], [ 1913: 3-CF3-6- (N-AC-N-Me-N) -2-Py], [1914: 4-CF3-6- (N-AC-N-Me-N) -2-Py] [1915: 5-CF3-6- (N-AC-N-Me-N) -2-Py], [1916: 3-CN-6- (N-AC-N-Me-N) -2- Py], [1917: 4-CN-6- (N-AC-N-Me-N) -2-Py], [1918: 5-CN-6- (N-AC-N-Me-N)- 2-Py], [1919: 3-OMe-6- (N-AC-N-Me-N) -2-Py], [1920: 4-OMe-6- (N-AC-N-Me-N). ) -2-Py], [19 1: 5-OMe-6- (N-AC-N-Me-N) -2-Py], [1922: 3-AC-2-Py], [1923: 4-Cl-3-AC-2- Py], [1924: 5-Cl-3-AC-2-Py], [1925: 6-Cl-3-AC-2-Py], [1926: 4-Me-3-AC-2-Py] [1927: 5-Me-3-AC-2-Py], [1928: 6-Me-3-AC-2-Py], [1929: 4-CF3-3-AC-2-Py], [ 1930: 5-CF3-3-3-AC-2-Py], [1931: 6-CF3-3-3-AC-2-Py], [1932: 4-CN-3-AC-2-Py], [1933: 5-CN-3-AC-2-Py], [1934: 6-CN-3-AC-2-Py], [1935: 4-OMe-3-AC-2- Py], [1936: 5-OMe-3-AC-2-Py], [1937: 6-OMe-3-AC-2-Py], [1937: 4-AC-2-Py], [1939: 3-Cl-4-AC-2-Py], [1940: 5-Cl-4-AC-2-Py], [1941: 6-Cl-4-AC-2-Py], [1942: 3- Me-4-AC-2-Py], [1943: 5-Me-4-AC-2-Py], [1944: 6-Me-4-AC-2-Py], [1945: 3-CF3- 4-AC-2-Py], [1946: 5-CF3-4-AC-2-Py], [1947: 6-CF3-4-AC-2-Py], [1948: 3-CN-4- AC-2-Py], [1949: 5-CN-4-AC-2-Py], [1950: 6-CN-4-AC-2-Py] [1951: 3-OMe-4-AC-2-Py], [1952: 5-OMe-4-AC-2-Py], [1953: 6-OMe-4-AC-2-Py], [1954 : 5-AC-2-Py], [1955: 3-Cl-5-AC-2-Py], [1956: 4-Cl-5-AC-2-Py], [1957: 6-Cl-5. -AC-2-Py], [1958: 3-Me-5-AC-2-Py], [1959: 4-Me-5-AC-2-Py], [1960: 6-Me-5-AC. -2-Py], [1961: 3-CF3-5-AC-2-Py], [1962: 4-CF3-5-AC-2-Py], [1963: 6-CF3-5-AC-2 -Py], [1964: 3-CN-5-AC-2-Py], [1965: 4-CN-5-AC-2-Py], [ 966: 6-CN-5-AC-2-Py], [1967: 3-OMe-5-AC-2-Py], [1968: 4-OMe-5-AC-2-Py], [1969: 6-OMe-5-AC-2-Py], [1970: 6-AC-2-Py], [1971: 3-Cl-6-AC-2-Py], [1972: 4-Cl-6 AC-2-Py], [1973: 5-Cl-6-AC-2-Py], [1974: 3-Me-6-AC-2-Py], [1975: 4-Me-6-AC- 2-Py], [1976: 5-Me-6-AC-2-Py], [1977: 3-CF3-6-AC-2-Py], [1978: 4-CF3-6-AC-2- Py], [1979: 5-CF3-6-AC-2-Py], [1980: 3-CN-6-AC-2-Py], [198 1: 4-CN-6-AC-2-Py], [1982: 5-CN-6-AC-2-Py], [1983: 3-OMe-6-AC-2-Py], [1984: 4-OMe-6-AC-2-Py], [1985: 5-OMe-6-AC-2-Py], [1986: 3-Py], [1987: 2-F-3-Py], [ 1988: 4-Cl-2-F-3-Py], [1989: 5-Cl-2-F-3-Py], [1990: 6-Cl-2-F-3-Py], [1991: 4-Me-2-F-3-Py], [1992: 5-Me-2-F-3-Py], [1993: 6-Me-2-F-3-Py], [1994: 4- CF3-2-F-3-Py], [1995: 5-CF3-2-F-3-Py], [1996: 6-CF3-2-F-3-Py], [199 : 4-CN-2-F-3-Py], [1998: 5-CN-2-F-3-Py], [1999: 6-CN-2-F-3-Py], [2000: 4 -OMe-2-F-3-Py],

[2001: 5-OMe-2-F-3-Py], [2002: 6-OMe-2-F-3-Py], [2003: 4-F-3-Py], [2004: 2-Cl -4-F-3-Py], [2005: 5-Cl-4-F-3-Py], [2006: 6-Cl-4-F-3-Py], [2007: 2-Me-4 -F-3-Py], [2008: 5-Me-4-F-3-Py], [2009: 6-Me-4-F-3-Py], [2010: 2-CF3-4-F -3-Py], [2011: 5-CF3-4-F-3-Py], [2012: 6-CF3-4-F-3-Py], [2013: 2-CN-4-F-3] -Py], [2014: 5-CN-4-F-3-Py], [2015: 6-CN-4-F-3-Py], [2016: 2-OMe-4-F-3- y], [2017: 5-OMe-4-F-3-Py], [2018: 6-OMe-4-F-3-Py], [2019: 5-F-3-Py], [2020: 2-Cl-5-F-3-Py], [2021: 4-Cl-5-F-3-Py], [2022: 6-Cl-5-F-3-Py], [2023: 2- Me-5-F-3-Py], [2024: 4-Me-5-F-3-Py], [2025: 6-Me-5-F-3-Py], [2026: 2-CF3- 5-F-3-Py], [2027: 4-CF3-5-F-3-Py], [2028: 6-CF3-5-F-3-Py], [2029: 2-CN-5 F-3-Py], [2030: 4-CN-5-F-3-Py], [2031: 6-CN-5-F-3-Py], [2032: 2-OMe-5-5 -3-Py], [2033: 4-OMe-5-F-3-Py], [2034: 6-OMe-5-F-3-Py], [2035: 6-F-3-Py], [2036: 2-Cl-6-F-3-Py], [2037: 4-Cl-6-F-3-Py], [2038: 5-Cl-6-F-3-Py], [2039 : 2-Me-6-F-3-Py], [2040: 4-Me-6-F-3-Py], [2041: 5-Me-6-F-3-Py], [2042: 2 -CF3-6-F-3-Py], [2043: 4-CF3-6-F-3-Py], [2044: 5-CF3-6-F-3-Py], [2045: 2-CN -6-F-3-Py], [2046: 4-CN-6-F-3-Py], [2047: 5-CN-6-F-3-Py], [2048: 2-OMe. -6-F-3-Py], [2049: 4-OMe-6-F-3-Py], [2050: 5-OMe-6-F-3-Py], [2051: 2-Cl-3. -Py], [2052: 4-Cl-2-Cl-3-Py], [2053: 5-Cl-2-Cl-3-Py], [2054: 6-Cl-2-Cl-3-Py ], [2055: 4-Me-2-Cl-3-Py], [2056: 5-Me-2-Cl-3-Py], [2057: 6-Me-2-Cl-3-Py], [2058: 4-CF3-2-Cl-3-Py], [2059: 5-CF3-2-Cl-3-Py], [2060: 6-CF3-2-Cl-3-Py], [2061] : 4-CN-2-Cl-3-Py], [2062: 5-CN-2-Cl-3-Py], [2063: 6-CN-2-Cl- -Py], [2064: 4-OMe-2-Cl-3-Py], [2065: 5-OMe-2-Cl-3-Py], [2066: 6-OMe-2-Cl-3-Py ], [2067: 4-Cl-3-Py], [2068: 2-Cl-4-Cl-3-Py], [2069: 5-Cl-4-Cl-3-Py], [2070: 6] -Cl-4-Cl-3-Py], [2071: 2-Me-4-Cl-3-Py], [2072: 5-Me-4-Cl-3-Py], [2073: 6-Me -4-Cl-3-Py], [2074: 2-CF3-4-Cl-3-Py], [2075: 5-CF3-4-Cl-3-Py], [2076: 6-CF3-4 -Cl-3-Py], [2077: 2-CN-4-Cl-3-Py], [2078: 5-CN-4-Cl-3- y], [2079: 6-CN-4-Cl-3-Py], [2080: 2-OMe-4-Cl-3-Py], [2081: 5-OMe-4-Cl-3-Py] [2082: 6-OMe-4-Cl-3-Py], [2083: 5-Cl-3-Py], [2084: 4-Cl-5-Cl-3-Py], [2085: 5- Cl-5-Cl-3-Py], [2086: 6-Cl-5-Cl-3-Py], [2087: 4-Me-5-Cl-3-Py], [2088: 5-Me- 5-Cl-3-Py], [2089: 6-Me-5-Cl-3-Py], [2090: 4-CF3-5-Cl-3-Py], [2091: 5-CF3-5 Cl-3-Py], [2092: 6-CF3-5-Cl-3-Py], [2093: 4-CN-5-Cl-3-Py] [2094: 3-CN-5-Cl-3-Py], [2095: 6-CN-5-Cl-3-Py], [2096: 4-OMe-5-Cl-3-Py], [ 2097: 5-OMe-5-Cl-3-Py], [2098: 6-OMe-5-Cl-3-Py], [2099: 6-Cl-3-Py], [2100: 2-Cl- 6-Cl-3-Py],

[2101: 4-Cl-6-Cl-3-Py], [2102: 5-Cl-6-Cl-3-Py], [2103: 2-Me-6-Cl-3-Py], [2104 : 4-Me-6-Cl-3-Py], [2105: 5-Me-6-Cl-3-Py], [2106: 2-CF3-6-Cl-3-Py], [2107: 4 -CF3-6-Cl-3-Py], [2108: 5-CF3-6-Cl-3-Py], [2109: 2-CN-6-Cl-3-Py], [2110: 4-CN -6-Cl-3-Py], [2111: 5-CN-6-Cl-3-Py], [2112: 2-OMe-6-Cl-3-Py], [2113: 4-OMe-6 -Cl-3-Py], [2114: 5-OMe-6-Cl-3-Py], [2115: 2-Br-3-Py], [2 16: 4-Cl-2-Br-3-Py], [2117: 5-Cl-2-Br-3-Py], [2118: 6-Cl-2-Br-3-Py], [2119: 4-Me-2-Br-3-Py], [2120: 5-Me-2-Br-3-Py], [2121: 6-Me-2-Br-3-Py], [2122: 4- CF3-2-Br-3-Py], [2123: 5-CF3-2-Br-3-Py], [2124: 6-CF3-2-Br-3-Py], [2125: 4-CN- 2-Br-3-Py], [2126: 5-CN-2-Br-3-Py], [2127: 6-CN-2-Br-3-Py], [2128: 4-OMe-2- Br-3-Py], [2129: 5-OMe-2-Br-3-Py], [2130: 6-OMe-2-Br-3-Py] [2131: 4-Br-3-Py], [2132: 2-Cl-4-Br-3-Py], [2133: 5-Cl-4-Br-3-Py], [2134: 6-Cl -4-Br-3-Py], [2135: 2-Me-4-Br-3-Py], [2136: 5-Me-4-Br-3-Py], [2137: 6-Me-4 -Br-3-Py], [2138: 2-CF3-4-Br-3-Py], [2139: 5-CF3-4-Br-3-Py], [2140: 6-CF3-4-Br -3-Py], [2141: 2-CN-4-Br-3-Py], [2142: 5-CN-4-Br-3-Py], [2143: 6-CN-4-Br-3. -Py], [2144: 2-OMe-4-Br-3-Py], [2145: 5-OMe-4-Br-3-Py], [21 46: 6-OMe-4-Br-3-Py], [2147: 5-Br-3-Py], [2148: 2-Cl-5-Br-3-Py], [2149: 4-Cl- 5-Br-3-Py], [2150: 6-Cl-5-Br-3-Py], [2151: 2-Me-5-Br-3-Py], [2152: 4-Me-5 Br-3-Py], [2153: 6-Me-5-Br-3-Py], [2154: 2-CF3-5-Br-3-Py], [2155: 4-CF3-5-Br- 3-Py], [2156: 6-CF3-5-Br-3-Py], [2157: 2-CN-5-Br-3-Py], [2158: 4-CN-5-Br-3- Py], [2159: 6-CN-5-Br-3-Py], [2160: 2-OMe-5-Br-3-Py], [2161: -OMe-5-Br-3-Py], [2162: 6-OMe-5-Br-3-Py], [2163: 6-Br-3-Py], [2164: 2-Cl-6-Br -3-Py], [2165: 4-Cl-6-Br-3-Py], [2166: 5-Cl-6-Br-3-Py], [2167: 2-Me-6-Br-3 -Py], [2168: 4-Me-6-Br-3-Py], [2169: 5-Me-6-Br-3-Py], [2170: 2-CF3-6-Br-3-Py] ], [2171: 4-CF3-6-Br-3-Py], [2172: 5-CF3-6-Br-3-Py], [2173: 2-CN-6-Br-3-Py], [2174: 4-CN-6-Br-3-Py], [2175: 5-CN-6-Br-3-Py], [2176: 2-O e-6-Br-3-Py], [2177: 4-OMe-6-Br-3-Py], [2178: 5-OMe-6-Br-3-Py], [2179: 2-I- 3-Py], [2180: 4-Cl-2-I-3-Py], [2181: 5-Cl-2-I-3-Py], [2182: 6-Cl-2-I-3- Py], [2183: 4-Me-2-I-3-Py], [2184: 5-Me-2-I-3-Py], [2185: 6-Me-2-I-3-Py] [2186: 4-CF3-2-I-3-Py], [2187: 5-CF3-2-I-3-Py], [2188: 6-CF3-2-I-3-Py], [ 2189: 4-CN-2-I-3-Py], [2190: 5-CN-2-I-3-Py], [2191: 6-CN-2-I-3-Py], [21 92: 4-OMe-2-I-3-Py], [2193: 5-OMe-2-I-3-Py], [2194: 6-OMe-2-I-3-Py], [2195: 4-I-3-Py], [2196: 2-Cl-4-I-3-Py], [2197: 5-Cl-4-I-3-Py], [2198: 6-Cl-4- I-3-Py], [2199: 2-Me-4-I-3-Py], [2200: 5-Me-4-I-3-Py],

[2201: 6-Me-4-I-3-Py], [2202: 2-CF3-4-I-3-Py], [2203: 5-CF3-4-I-3-Py], [2204 : 6-CF3-4-I-3-Py], [2205: 2-CN-4-I-3-Py], [2206: 5-CN-4-I-3-Py], [2207: 6 -CN-4-I-3-Py], [2208: 2-OMe-4-I-3-Py], [2209: 5-OMe-4-I-3-Py], [2210: 6-OMe -4-I-3-Py], [2211: 5-I-3-Py], [2212: 2-Cl-5-I-3-Py], [2213: 4-Cl-5-I-3 -Py], [2214: 6-Cl-5-I-3-Py], [2215: 2-Me-5-I-3-Py], [2216: 4-Me-5-I-3- y], [2217: 6-Me-5-I-3-Py], [2218: 2-CF3-5-I-3-Py], [2219: 4-CF3-5-I-3-Py] [2220: 6-CF3-5-I-3-Py], [2221: 2-CN-5-I-3-Py], [2222: 4-CN-5-I-3-Py], [ 2223: 6-CN-5-I-3-Py], [2224: 2-OMe-5-I-3-Py], [2225: 4-OMe-5-I-3-Py], [2226: 6-OMe-5-I-3-Py], [2227: 6-I-3-Py], [2228: 2-Cl-6-I-3-Py], [2229: 4-Cl-6 I-3-Py], [2230: 5-Cl-6-I-3-Py], [2231: 2-Me-6-I-3-Py], [2232: 4-Me-6-6 -3-Py], [2233: 5-Me-6-I-3-Py], [2234: 2-CF3-6-I-3-Py], [2235: 4-CF3-6-I-3 -Py], [2236: 5-CF3-6-I-3-Py], [2237: 2-CN-6-I-3-Py], [2238: 4-CN-6-I-3-Py ], [2239: 5-CN-6-I-3-Py], [2240: 2-OMe-6-I-3-Py], [2241: 4-OMe-6-I-3-Py], [2242: 5-OMe-6-I-3-Py], [2243: 2-Me-3-Py], [2244: 4-Cl-2-Me-3-Py], [2245: 5-Cl -2-Me-3-Py], [2246: 6-Cl-2-Me-3-Py], [2247: 4-Me-2-Me-3-Py], [2248 : 5-Me-2-Me-3-Py], [2249: 6-Me-2-Me-3-Py], [2250: 4-CF3-2-Me-3-Py], [2251: 5 -CF3-2-Me-3-Py], [2252: 6-CF3-2-Me-3-Py], [2253: 4-CN-2-Me-3-Py], [2254: 5-CN -2-Me-3-Py], [2255: 6-CN-2-Me-3-Py], [2256: 4-OMe-2-Me-3-Py], [2257: 5-OMe-2 -Me-3-Py], [2258: 6-OMe-2-Me-3-Py], [2259: 4-Me-3-Py], [2260: 2-Cl-4-Me-3-Py ], [2261: 5-Cl-4-Me-3-Py], [2262: 6-Cl-4-Me-3-Py], [2263: 2 Me-4-Me-3-Py], [2264: 5-Me-4-Me-3-Py], [2265: 6-Me-4-Me-3-Py], [2266: 2-CF3- 4-Me-3-Py], [2267: 5-CF3-4-Me-3-Py], [2268: 6-CF3-4-Me-3-Py], [2269: 2-CN-4- Me-3-Py], [2270: 5-CN-4-Me-3-Py], [2271: 6-CN-4-Me-3-Py], [2272: 2-OMe-4-Me- 3-Py], [2273: 5-OMe-4-Me-3-Py], [2274: 6-OMe-4-Me-3-Py], [2275: 5-Me-3-Py], [ 2276: 2-Cl-5-Me-3-Py], [2277: 4-Cl-5-Me-3-Py], [2278: 6-C -5-Me-3-Py], [2279: 2-Me-5-Me-3-Py], [2280: 4-Me-5-Me-3-Py], [2281: 6-Me-5 -Me-3-Py], [2282: 2-CF3-5-Me-3-Py], [2283: 4-CF3-5-Me-3-Py], [2284: 6-CF3-5-Me -3-Py], [2285: 2-CN-5-Me-3-Py], [2286: 4-CN-5-Me-3-Py], [2287: 6-CN-5-Me-3. -Py], [2288: 2-OMe-5-Me-3-Py], [2289: 4-OMe-5-Me-3-Py], [2290: 6-OMe-5-Me-3-Py ], [2291: 6-Me-3-Py], [2292: 2-Cl-6-Me-3-Py], [2293: 4-Cl-6]. -Me-3-Py], [2294: 5-Cl-6-Me-3-Py], [2295: 2-Me-6-Me-3-Py], [2296: 4-Me-6-Me -3-Py], [2297: 5-Me-6-Me-3-Py], [2298: 2-CF3-6-Me-3-Py], [2299: 4-CF3-6-Me-3. -Py], [2300: 5-CF3-6-Me-3-Py],

[2301: 2-CN-6-Me-3-Py], [2302: 4-CN-6-Me-3-Py], [2303: 5-CN-6-Me-3-Py], [2304 : 2-OMe-6-Me-3-Py], [2305: 4-OMe-6-Me-3-Py], [2306: 5-OMe-6-Me-3-Py], [2307: 2 -OMe-3-Py], [2308: 4-Cl-2-OMe-3-Py], [2309: 5-Cl-2-OMe-3-Py], [2310: 6-Cl-2-OMe -3-Py], [2311: 4-Me-2-OMe-3-Py], [2312: 5-Me-2-OMe-3-Py], [2313: 6-Me-2-OMe-3 -Py], [2314: 4-CF3-2-OMe-3-Py], [2315: 5-CF3-2-OMe- -Py], [2316: 6-CF3-2-OMe-3-Py], [2317: 4-CN-2-OMe-3-Py], [2318: 5-CN-2-OMe-3-Py] ], [2319: 6-CN-2-OMe-3-Py], [2320: 4-OMe-2-OMe-3-Py], [2321: 5-OMe-2-OMe-3-Py], [2322: 6-OMe-2-OMe-3-Py], [2323: 4-OMe-3-Py], [2324: 2-Cl-4-OMe-3-Py], [2325: 5-Cl -4-OMe-3-Py], [2326: 6-Cl-4-OMe-3-Py], [2327: 2-Me-4-OMe-3-Py], [2328: 5-Me-4 -OMe-3-Py], [2329: 6-Me-4-OMe-3-Py], [2330: -CF3-4-OMe-3-Py], [2331: 5-CF3-4-OMe-3-Py], [2332: 6-CF3-4-OMe-3-Py], [2333: 2-CN -4-OMe-3-Py], [2334: 5-CN-4-OMe-3-Py], [2335: 6-CN-4-OMe-3-Py], [2336: 2-OMe-4 -OMe-3-Py], [2337: 5-OMe-4-OMe-3-Py], [2338: 6-OMe-4-OMe-3-Py], [2339: 5-OMe-3-Py] ], [2340: 2-Cl-5-OMe-3-Py], [2341: 4-Cl-5-OMe-3-Py], [2342: 6-Cl-5-OMe-3-Py], [2343: 2-Me-5-OMe-3-Py], [2344: 4-Me-5-OMe- 3-Py], [2345: 6-Me-5-OMe-3-Py], [2346: 2-CF3-5-OMe-3-Py], [2347: 4-CF3-5-OMe-3- Py], [2348: 6-CF3-5-OMe-3-Py], [2349: 2-CN-5-OMe-3-Py], [2350: 4-CN-5-OMe-3-Py] , [2351: 6-CN-5-OMe-3-Py], [2352: 2-OMe-5-OMe-3-Py], [2353: 4-OMe-5-OMe-3-Py], [ 2354: 6-OMe-5-OMe-3-Py], [2355: 6-OMe-3-Py], [2356: 2-Cl-6-OMe-3-Py], [2357: 4-Cl- 6-OMe-3-Py], [2358: 5-Cl-6-OMe-3-Py], [235 : 2-Me-6-OMe-3-Py], [2360: 4-Me-6-OMe-3-Py], [2361: 5-Me-6-OMe-3-Py], [2362: 2 -CF3-6-OMe-3-Py], [2363: 4-CF3-6-OMe-3-Py], [2364: 5-CF3-6-OMe-3-Py], [2365: 2-CN -6-OMe-3-Py], [2366: 4-CN-6-OMe-3-Py], [2367: 5-CN-6-OMe-3-Py], [2368: 2-OMe-6 -OMe-3-Py], [2369: 4-OMe-6-OMe-3-Py], [2370: 5-OMe-6-OMe-3-Py], [2371: 2-CF3-3-Py] ], [2372: 4-Cl-2-CF3-3-Py], [2373: 5-Cl-2-C 3-3-Py], [2374: 6-Cl-2-CF3-3-Py], [2375: 4-Me-2-CF3-3-Py], [2376: 5-Me-2-CF3- 3-Py], [2377: 6-Me-2-CF3-3-Py], [2378: 4-CF3-2-CF3-3-Py], [2379: 5-CF3-2-CF3-3 Py], [2380: 6-CF3-2-CF3-3-Py], [2381: 4-CN-2-CF3-3-Py], [2382: 5-CN-2-CF3-3-Py] [2383: 6-CN-2-CF3-3-Py], [2384: 4-OMe-2-CF3-3-Py], [2385: 5-OMe-2-CF3-3-Py], [ 2386: 6-OMe-2-CF3-3-Py], [2387: 4-CF3-3-Py], [2 388: 2-Cl-4-CF3-3-Py], [2389: 5-Cl-4-CF3-3-Py], [2390: 6-Cl-4-CF3-3-Py], [2391: 2-Me-4-CF3-3-Py], [2392: 5-Me-4-CF3-3-Py], [2393: 6-Me-4-CF3-3-Py], [2394: 2- CF3-4-CF3-3-Py], [2395: 5-CF3-4-CF3-3-Py], [2396: 6-CF3-4-CF3-3-Py], [2397: 2-CN- 4-CF3-3-Py], [2398: 5-CN-4-CF3-3-Py], [2399: 6-CN-4-CF3-3-Py], [2400: 2-OMe-4- CF3-3-Py],

[2401: 5-OMe-4-CF3-3-Py], [2402: 6-OMe-4-CF3-3-Py], [2403: 5-CF3-3-Py], [2404: 2-Cl -5-CF3-3-Py], [2405: 4-Cl-5-CF3-3-Py], [2406: 6-Cl-5-CF3-3-Py], [2407: 2-Me-5. -CF3-3-Py], [2408: 4-Me-5-CF3-3-Py], [2409: 6-Me-5-CF3-3-Py], [2410: 2-CF3-5-CF3 -3-Py], [2411: 4-CF3-5-CF3-3-Py], [2412: 6-CF3-5-CF3-3-Py], [2413: 2-CN-5-CF3-3) -Py], [2414: 4-CN-5-CF3-3-Py], [2415: 6-CN- -CF3-3-Py], [2416: 2-OMe-5-CF3-3-Py], [2417: 4-OMe-5-CF3-3-Py], [2418: 6-OMe-5-CF3 -3-Py], [2419: 6-CF3-3-Py], [2420: 2-Cl-6-CF3-3-Py], [2421: 4-Cl-6-CF3-3-Py], [2422: 5-Cl-6-CF3-3-Py], [2423: 2-Me-6-CF3-3-Py], [2424: 4-Me-6-CF3-3-Py], [2425 : 5-Me-6-CF3-3-Py], [2426: 2-CF3-6-CF3-3-Py], [2427: 4-CF3-6-CF3-3-Py], [2428: 5 -CF3-6-CF3-3-Py], [2429: 2-CN-6-CF3-3-Py [2430: 4-CN-6-CF3-3-Py], [2431: 5-CN-6-CF3-3-Py], [2432: 2-OMe-6-CF3-3-Py], [ 2433: 4-OMe-6-CF3-3-Py], [2434: 5-OMe-6-CF3-3-Py], [2435: 2-OCF3-3-Py], [2436: 4-Cl- 2-OCF3-3-Py], [2437: 5-Cl-2-OCF3-3-Py], [2438: 6-Cl-2-OCF3-3-Py], [2439: 4-Me-2-] OCF3-3-Py], [2440: 5-Me-2-OCF3-3-Py], [2441: 6-Me-2-OCF3-3-Py], [2442: 4-CF3-2-OCF3- 3-Py], [2443: 5-CF3-2-OCF3-3-Py], [ 2444: 6-CF3-2-OCF3-3-Py], [2445: 4-CN-2-OCF3-3-Py], [2446: 5-CN-2-OCF3-3-Py], [2447: 6-CN-2-OCF3-3-Py], [2448: 4-OMe-2-OCF3-3-Py], [2449: 5-OMe-2-OCF3-3-Py], [2450: 6- OMe-2-OCF3-3-Py], [2451: 4-OCF3-3-Py], [2452: 2-Cl-4-OCF3-3-Py], [2453: 5-Cl-4-OCF3- 3-Py], [2454: 6-Cl-4-OCF3-3-Py], [2455: 2-Me-4-OCF3-3-Py], [2456: 5-Me-4-OCF3-3 Py], [2457: 6-Me-4-OCF3-3-Py] [2458: 2-CF3-4-OCF3-3-Py], [2259: 5-CF3-4-OCF3-3-Py], [2460: 6-CF3-4-OCF3-3-Py], [2461 : 2-CN-4-OCF3-3-Py], [2462: 5-CN-4-OCF3-3-Py], [2463: 6-CN-4-OCF3-3-Py], [2464: 2] -OMe-4-OCF3-3-Py], [2465: 5-OMe-4-OCF3-3-Py], [2466: 6-OMe-4-OCF3-3-Py], [2467: 5-OCF3 -3-Py], [2468: 2-Cl-5-OCF3-3-Py], [2469: 4-Cl-5-OCF3-3-Py], [2470: 6-Cl-5-OCF3-3. -Py], [2471: 2-Me-5-OCF3-3. Py], [2472: 4-Me-5-OCF3-3-Py], [2473: 6-Me-5-OCF3-3-Py], [2474: 2-CF3-5-OCF3-3-Py] [2475: 4-CF3-5-OCF3-3-Py], [2476: 6-CF3-5-OCF3-3-Py], [2477: 2-CN-5-OCF3-3-Py], [ 2478: 4-CN-5-OCF3-3-Py], [2479: 6-CN-5-OCF3-3-Py], [2480: 2-OMe-5-OCF3-3-Py], [2481: 4-OMe-5-OCF3-3-Py], [2482: 6-OMe-5-OCF3-3-Py], [2483: 6-OCF3-3-Py], [2484: 2-Cl-6 OCF3-3-Py], [2485: 4-Cl-6-OCF 3-3-3-Py], [2486: 5-Cl-6-OCF3-3-Py], [2487: 2-Me-6-OCF3-3-Py], [2488: 4-Me-6-OCF3- 3-Py], [2489: 5-Me-6-OCF3-3-Py], [2490: 2-CF3-6-OCF3-3-Py], [2491: 4-CF3-6-OCF3-3- Py], [2492: 5-CF3-6-OCF3-3-Py], [2493: 2-CN-6-OCF3-3-Py], [2494: 4-CN-6-OCF3-3-Py] [2495: 5-CN-6-OCF3-3-Py], [2496: 2-OMe-6-OCF3-3-Py], [2497: 4-OMe-6-OCF3-3-Py], [ 2498: 5-OMe-6-OCF3-3-Py], [2499: 2 CHF2-3-Py], [2500: 4-Cl-2-CHF2-3-Py],

[2501: 5-Cl-2-CHF2-3-Py], [2502: 6-Cl-2-CHF2-3-Py], [2503: 4-Me-2-CHF2-3-Py], [2504 : 5-Me-2-CHF2-3-Py], [2505: 6-Me-2-CHF2-3-Py], [2506: 4-CF3-2-CHF2-3-Py], [2507: 5 -CF3-2-CHF2-3-Py], [2508: 6-CF3-2-CHF2-3-Py], [2509: 4-CN-2-CHF2-3-Py], [2510: 5-CN -2-CHF2-3-Py], [2511: 6-CN-2-CHF2-3-Py], [2512: 4-OMe-2-CHF2-3-Py], [2513: 5-OMe-2 -CHF2-3-Py], [2514: 6-OMe-2-CH 2-3-Py], [2515: 4-CHF2-3-Py], [2516: 2-Cl-4-CHF2-3-Py], [2517: 5-Cl-4-CHF2-3-Py] [2518: 6-Cl-4-CHF2-3-Py], [2519: 2-Me-4-CHF2-3-Py], [2520: 5-Me-4-CHF2-3-Py], [ 2521: 6-Me-4-CHF2-3-Py], [2522: 2-CF3-4-CHF2-3-Py], [2523: 5-CF3-4-CHF2-3-Py], [2524: 6-CF3-4-CHF2-3-Py], [2525: 2-CN-4-CHF2-3-Py], [2526: 5-CN-4-CHF2-3-Py], [2527: 6- CN-4-CHF2-3-Py], [2528: 2-OMe-4- HF2-3-Py], [2529: 5-OMe-4-CHF2-3-Py], [2530: 6-OMe-4-CHF2-3-Py], [2531: 5-CHF2-3-Py] [2532: 2-Cl-5-CHF2-3-Py], [2533: 4-Cl-5-CHF2-3-Py], [2534: 6-Cl-5-CHF2-3-Py], [ 2535: 2-Me-5-CHF2-3-Py], [2536: 4-Me-5-CHF2-3-Py], [2537: 6-Me-5-CHF2-3-Py], [2538: 2-CF3-5-CHF2-3-Py], [2539: 4-CF3-5-CHF2-3-Py], [2540: 6-CF3-5-CHF2-3-Py], [2541: 2- CN-5-CHF2-3-Py], [2542: 4-CN- 5-CHF2-3-Py], [2543: 6-CN-5-CHF2-3-Py], [2544: 2-OMe-5-CHF2-3-Py], [2545: 4-OMe-5 CHF2-3-Py], [2546: 6-OMe-5-CHF2-3-Py], [2547: 6-CHF2-3-Py], [2548: 2-Cl-6-CHF2-3-Py] [2549: 4-Cl-6-CHF2-3-Py], [2550: 5-Cl-6-CHF2-3-Py], [2551: 2-Me-6-CHF2-3-Py], [ 2552: 4-Me-6-CHF2-3-Py], [2553: 5-Me-6-CHF2-3-Py], [2554: 2-CF3-6-CHF2-3-Py], [2555: 4-CF3-6-CHF2-3-Py], [2556: 5- F3-6-CHF2-3-Py], [2557: 2-CN-6-CHF2-3-Py], [2558: 4-CN-6-CHF2-3-Py], [2559: 5-CN- 6-CHF2-3-Py], [2560: 2-OMe-6-CHF2-3-Py], [2561: 4-OMe-6-CHF2-3-Py], [2562: 5-OMe-6 CHF2-3-Py], [2563: 2-OCHF2-3-Py], [2564: 4-Cl-2-OCHF2-3-Py], [2565: 5-Cl-2-OCHF2-3-Py] [2566: 6-Cl-2-OCHF2-3-Py], [2567: 4-Me-2-OCHF2-3-Py], [2568: 5-Me-2-OCHF2-3-Py], [ 2569: 6-Me-2-OCHF2-3-Py] [2570: 4-CF3-2-OCHF2-3-Py], [2571: 5-CF3-2-OCHF2-3-Py], [2572: 6-CF3-2-OCHF2-3-Py], [2573 : 4-CN-2-OCHF2-3-Py], [2574: 5-CN-2-OCHF2-3-Py], [2575: 6-CN-2-OCHF2-3-Py], [2576: 4 -OMe-2-OCHF2-3-Py], [2577: 5-OMe-2-OCHF2-3-Py], [2578: 6-OMe-2-OCHF2-3-Py], [2579: 4-OCHF2 -3-Py], [2580: 2-Cl-4-OCHF2-3-Py], [2581: 5-Cl-4-OCHF2-3-Py], [2582: 6-Cl-4-OCHF2-3 -Py], [2583: 2 -Me-4-OCHF2-3-Py], [2584: 5-Me-4-OCHF2-3-Py], [2585: 6-Me-4-OCHF2-3-Py], [2586: 2-CF3 -4-OCHF2-3-Py], [2588: 5-CF3-4-OCHF2-3-Py], [2588: 6-CF3-4-OCHF2-3-Py], [2589: 2-CN-4 -OCHF2-3-Py], [2590: 5-CN-4-OCHF2-3-Py], [2591: 6-CN-4-OCHF2-3-Py], [2592: 2-OMe-4-OCHF2 -3-Py], [2593: 5-OMe-4-OCHF2-3-Py], [2594: 6-OMe-4-OCHF2-3-Py], [2595: 5-OCHF2-3-Py], [2596: 2-Cl-5-O HF2-3-Py], [2597: 4-Cl-5-OCHF2-3-Py], [2598: 6-Cl-5-OCHF2-3-Py], [2599: 2-Me-5-OCHF2- 3-Py], [2600: 4-Me-5-OCHF2-3-Py],

[2601: 6-Me-5-OCHF2-3-Py], [2602: 2-CF3-5-OCHF2-3-Py], [2603: 4-CF3-5-OCHF2-3-Py], [2604] : 6-CF3-5-OCHF2-3-Py], [2605: 2-CN-5-OCHF2-3-Py], [2606: 4-CN-5-OCHF2-3-Py], [2607: 6 -CN-5-OCHF2-3-Py], [2608: 2-OMe-5-OCHF2-3-Py], [2609: 4-OMe-5-OCHF2-3-Py], [2610: 6-OMe -5-OCHF2-3-Py], [2611: 6-OCHF2-3-Py], [2612: 2-Cl-6-OCHF2-3-Py], [2613: 4-Cl-6-OCHF2-3 -Py], [2614: 5 Cl-6-OCHF2-3-Py], [2615: 2-Me-6-OCHF2-3-Py], [2616: 4-Me-6-OCHF2-3-Py], [2617: 5-Me- 6-OCHF2-3-Py], [2618: 2-CF3-6-OCHF2-3-Py], [2619: 4-CF3-6-OCHF2-3-Py], [2620: 5-CF3-6 OCHF2-3-Py], [2621: 2-CN-6-OCHF2-3-Py], [2622: 4-CN-6-OCHF2-3-Py], [2623: 5-CN-6-OCHF2- 3-Py], [2624: 2-OMe-6-OCHF2-3-Py], [2625: 4-OMe-6-OCHF2-3-Py], [2626: 5-OMe-6-OCHF2-3- Py], [2627: 2-E -3-Py], [2628: 4-Cl-2-Et-3-Py], [2629: 5-Cl-2-Et-3-Py], [2630: 6-Cl-2-Et-3 -Py], [2631: 4-Me-2-Et-3-Py], [2632: 5-Me-2-Et-3-Py], [2633: 6-Me-2-Et-3-Py] ], [2634: 4-CF3-2-Et-3-Py], [2635: 5-CF3-2-Et-3-Py], [2636: 6-CF3-2-Et-3-Py], [2638: 4-CN-2-Et-3-Py], [2638: 5-CN-2-Et-3-Py], [2539: 6-CN-2-Et-3-Py], [2640 : 4-OMe-2-Et-3-Py], [2641: 5-OMe-2-Et-3-Py], [2642: 6-OMe-2 -Et-3-Py], [2643: 4-Et-3-Py], [2644: 2-Cl-4-Et-3-Py], [2645: 5-Cl-4-Et-3-Py] ], [2646: 6-Cl-4-Et-3-Py], [2647: 2-Me-4-Et-3-Py], [2648: 5-Me-4-Et-3-Py], [2649: 6-Me-4-Et-3-Py], [2650: 2-CF3-4-Et-3-Py], [2651: 5-CF3-4-Et-3-Py], [2652] : 6-CF3-4-Et-3-Py], [2653: 2-CN-4-Et-3-Py], [2654: 5-CN-4-Et-3-Py], [2655: 6 -CN-4-Et-3-Py], [2656: 2-OMe-4-Et-3-Py], [2657: 5-OMe-4-Et 3-Py], [2658: 6-OMe-4-Et-3-Py], [2659: 5-Et-3-Py], [2660: 2-Cl-5-Et-3-Py], [ 2661: 4-Cl-5-Et-3-Py], [2662: 6-Cl-5-Et-3-Py], [2663: 2-Me-5-Et-3-Py], [2664: 4-Me-5-Et-3-Py], [2665: 6-Me-5-Et-3-Py], [2666: 2-CF3-5-Et-3-Py], [2667: 4- CF3-5-Et-3-Py], [2668: 6-CF3-5-Et-3-Py], [2669: 2-CN-5-Et-3-Py], [2670: 4-CN- 5-Et-3-Py], [2671: 6-CN-5-Et-3-Py], [2672: 2-OMe-5-Et-3- y], [2673: 4-OMe-5-Et-3-Py], [2674: 6-OMe-5-Et-3-Py], [2675: 6-Et-3-Py], [2676: 2-Cl-6-Et-3-Py], [2679: 4-Cl-6-Et-3-Py], [2678: 5-Cl-6-Et-3-Py], [2679: 2- Me-6-Et-3-Py], [2680: 4-Me-6-Et-3-Py], [2681: 5-Me-6-Et-3-Py], [2682: 2-CF3- 6-Et-3-Py], [2683: 4-CF3-6-Et-3-Py], [2684: 5-CF3-6-Et-3-Py], [2585: 2-CN-6 Et-3-Py], [2686: 4-CN-6-Et-3-Py], [2687: 5-CN-6-Et-3-Py], [2688: 2-OMe-6-Et-3-Py], [2687: 4-OMe-6-Et-3-Py], [2690: 5-OMe-6-Et-3-Py], [2691 : 2-CH2CF3-3-Py], [2692: 4-Cl-2-CH2CF3-3-Py], [2693: 5-Cl-2-CH2CF3-3-Py], [2694: 6-Cl-2 -CH2CF3-3-Py], [2695: 4-Me-2-CH2CF3-3-Py], [2696: 5-Me-2-CH2CF3-3-Py], [2697: 6-Me-2-CH2CF3 -3-Py], [2698: 4-CF3-2-CH2CF3-3-Py], [2699: 5-CF3-2-CH2CF3-3-Py], [2700: 6-CF3-2-CH2CF3-3 -Py],

[2701: 4-CN-2-CH2CF3-3-Py], [2702: 5-CN-2-CH2CF3-3-Py], [2703: 6-CN-2-CH2CF3-3-Py], [2704 : 4-OMe-2-CH2CF3-3-Py], [2705: 5-OMe-2-CH2CF3-3-Py], [2706: 6-OMe-2-CH2CF3-3-Py], [2707: 4 -CH2CF3-3-Py], [2708: 2-Cl-4-CH2CF3-3-Py], [2709: 5-Cl-4-CH2CF3-3-Py], [2710: 6-Cl-4-CH2CF3 -3-Py], [2711: 2-Me-4-CH2CF3-3-Py], [2712: 5-Me-4-CH2CF3-3-Py], [2713: 6-Me-4-CH2CF3-3 -P ], [2714: 2-CF3-4-CH2CF3-3-Py], [2715: 5-CF3-4-CH2CF3-3-Py], [2716: 6-CF3-4-CH2CF3-3-Py], [2717: 2-CN-4-CH2CF3-3-Py], [2718: 5-CN-4-CH2CF3-3-Py], [2719: 6-CN-4-CH2CF3-3-Py], [2720 : 2-OMe-4-CH2CF3-3-Py], [2721: 5-OMe-4-CH2CF3-3-Py], [2722: 6-OMe-4-CH2CF3-3-Py], [2723: 5] -CH2CF3-3-Py], [2724: 2-Cl-5-CH2CF3-3-Py], [2725: 4-Cl-5-CH2CF3-3-Py], [2726: 6-Cl-5-CH2C 3-3-Py], [2727: 2-Me-5-CH2CF3-3-Py], [2728: 4-Me-5-CH2CF3-3-Py], [2729: 6-Me-5-CH2CF3- 3-Py], [2730: 2-CF3-5-CH2CF3-3-Py], [2731: 4-CF3-5-CH2CF3-3-Py], [2732: 6-CF3-5-CH2CF3-3- Py], [2733: 2-CN-5-CH2CF3-3-Py], [2734: 4-CN-5-CH2CF3-3-Py], [2735: 6-CN-5-CH2CF3-3-Py] [2736: 2-OMe-5-CH2CF3-3-Py], [2737: 4-OMe-5-CH2CF3-3-Py], [2738: 6-OMe-5-CH2CF3-3-Py], [ 2739: 6 -CH2CF3-3-Py], [2740: 2-Cl-6-CH2CF3-3-Py], [2741: 4-Cl-6-CH2CF3-3-Py], [2742: 5-Cl-6-CH2CF3 -3-Py], [2743: 2-Me-6-CH2CF3-3-Py], [2744: 4-Me-6-CH2CF3-3-Py], [2745: 5-Me-6-CH2CF3-3. -Py], [2746: 2-CF3-6-CH2CF3-3-Py], [2747: 4-CF3-6-CH2CF3-3-Py], [2748: 5-CF3-6-CH2CF3-3-Py ], [2749: 2-CN-6-CH2CF3-3-Py], [2750: 4-CN-6-CH2CF3-3-Py], [2751: 5-CN-6-CH2CF3-3-Py], [275 : 2-OMe-6-CH2CF3-3-Py], [2753: 4-OMe-6-CH2CF3-3-Py], [2754: 5-OMe-6-CH2CF3-3-Py], [2755: 2] -OEt-3-Py], [2756: 4-Cl-2-OEt-3-Py], [2757: 5-Cl-2-OEt-3-Py], [2758: 6-Cl-2-OEt -3-Py], [2759: 4-Me-2-OEt-3-Py], [2760: 5-Me-2-OEt-3-Py], [2761: 6-Me-2-OEt-3 -Py], [2762: 4-CF3-2-OEt-3-Py], [2763: 5-CF3-2-OEt-3-Py], [2764: 6-CF3-2-OEt-3-Py] ], [2765: 4-CN-2-OEt-3-Py], [2766 5-CN-2-OEt-3-Py], [2767: 6-CN-2-OEt-3-Py], [2768: 4-OMe-2-OEt-3-Py], [2769: 5- OMe-2-OEt-3-Py], [2770: 6-OMe-2-OEt-3-Py], [2771: 4-OEt-3-Py], [2772: 2-Cl-4-OEt- 3-Py], [2773: 5-Cl-4-OEt-3-Py], [2774: 6-Cl-4-OEt-3-Py], [2775: 2-Me-4-OEt-3- Py], [2776: 5-Me-4-OEt-3-Py], [2777: 6-Me-4-OEt-3-Py], [2778: 2-CF3-4-OEt-3-Py] [2779: 5-CF3-4-OEt-3-Py], [2780: 6-CF3-4-OEt -3-Py], [2781: 2-CN-4-OEt-3-Py], [2782: 5-CN-4-OEt-3-Py], [2783: 6-CN-4-OEt-3 -Py], [2784: 2-OMe-4-OEt-3-Py], [2785: 5-OMe-4-OEt-3-Py], [2786: 6-OMe-4-OEt-3-Py ], [2787: 5-OEt-3-Py], [2788: 2-Cl-5-OEt-3-Py], [2789: 4-Cl-5-OEt-3-Py], [2790: 6 -Cl-5-OEt-3-Py], [2791: 2-Me-5-OEt-3-Py], [2792: 4-Me-5-OEt-3-Py], [2793: 6-Me -5-OEt-3-Py], [2794: 2-CF3-5-OEt-3-Py], [2795 4-CF3-5-OEt-3-Py], [2796: 6-CF3-5-OEt-3-Py], [2797: 2-CN-5-OEt-3-Py], [2798: 4- CN-5-OEt-3-Py], [2799: 6-CN-5-OEt-3-Py], [2800: 2-OMe-5-OEt-3-Py],

[2801: 4-OMe-5-OEt-3-Py], [2802: 6-OMe-5-OEt-3-Py], [2803: 6-OEt-3-Py], [2804: 2-Cl -6-OEt-3-Py], [2805: 4-Cl-6-OEt-3-Py], [2806: 5-Cl-6-OEt-3-Py], [2807: 2-Me-6 -OEt-3-Py], [2808: 4-Me-6-OEt-3-Py], [2809: 5-Me-6-OEt-3-Py], [2810: 2-CF3-6-OEt -3-Py], [2811: 4-CF3-6-OEt-3-Py], [2812: 5-CF3-6-OEt-3-Py], [2813: 2-CN-6-OEt-3 -Py], [2814: 4-CN-6-OEt-3-Py], [2815: 5-CN- -OEt-3-Py], [2816: 2-OMe-6-OEt-3-Py], [2817: 4-OMe-6-OEt-3-Py], [2818: 5-OMe-6-OEt -3-Py], [2819: 2-OCH2CF3-3-Py], [2820: 4-Cl-2-OCH2CF3-3-Py], [2821: 5-Cl-2-OCH2CF3-3-Py], [2822: 6-Cl-2-OCH2CF3-3-Py], [2823: 4-Me-2-OCH2CF3-3-Py], [2824: 5-Me-2-OCH2CF3-3-Py], [2825 : 6-Me-2-OCH2CF3-3-Py], [2826: 4-CF3-2-OCH2CF3-3-Py], [2827: 5-CF3-2-OCH2CF3-3-Py], [2828: 6 -C 3-2-OCH2CF3-3-Py], [2829: 4-CN-2-OCH2CF3-3-Py], [2830: 5-CN-2-OCH2CF3-3-Py], [2831: 6-CN- 2-OCH2CF3-3-Py], [2832: 4-OMe-2-OCH2CF3-3-Py], [2833: 5-OMe-2-OCH2CF3-3-Py], [2834: 6-OMe-2- OCH2CF3-3-Py], [2835: 4-OCH2CF3-3-Py], [2836: 2-Cl-4-OCH2CF3-3-Py], [2837: 5-Cl-4-OCH2CF3-3-Py] [2838: 6-Cl-4-OCH2CF3-3-Py], [2839: 2-Me-4-OCH2CF3-3-Py], [2840: 5-Me-4-OCH2CF3 -3-Py], [2841: 6-Me-4-OCH2CF3-3-Py], [2842: 2-CF3-4-OCH2CF3-3-Py], [2843: 5-CF3-4-OCH2CF3-3. -Py], [2844: 6-CF3-4-OCH2CF3-3-Py], [2845: 2-CN-4-OCH2CF3-3-Py], [2846: 5-CN-4-OCH2CF3-3-Py] ], [2847: 6-CN-4-OCH2CF3-3-Py], [2848: 2-OMe-4-OCH2CF3-3-Py], [2849: 5-OMe-4-OCH2CF3-3-Py], [2850: 6-OMe-4-OCH2CF3-3-Py], [2851: 5-OCH2CF3-3-Py], [2852: 2-Cl-5-OCH2CF3-3-Py], [ 853: 4-Cl-5-OCH2CF3-3-Py], [2854: 6-Cl-5-OCH2CF3-3-Py], [2855: 2-Me-5-OCH2CF3-3-Py], [2856: 4-Me-5-OCH2CF3-3-Py], [2857: 6-Me-5-OCH2CF3-3-Py], [2858: 2-CF3-5-OCH2CF3-3-Py], [2859: 4- CF3-5-OCH2CF3-3-Py], [2860: 6-CF3-5-OCH2CF3-3-Py], [2861: 2-CN-5-OCH2CF3-3-Py], [2862: 4-CN- 5-OCH2CF3-3-Py], [2863: 6-CN-5-OCH2CF3-3-Py], [2864: 2-OMe-5-OCH2CF3-3-Py], [2865: -OMe-5-OCH2CF3-3-Py], [2866: 6-OMe-5-OCH2CF3-3-Py], [2867: 6-OCH2CF3-3-Py], [2868: 2-Cl-6-OCH2CF3 -3-Py], [2869: 4-Cl-6-OCH2CF3-3-Py], [2870: 5-Cl-6-OCH2CF3-3-Py], [2871: 2-Me-6-OCH2CF3-3. -Py], [2872: 4-Me-6-OCH2CF3-3-Py], [2873: 5-Me-6-OCH2CF3-3-Py], [2874: 2-CF3-6-OCH2CF3-3-Py]. ], [2875: 4-CF3-6-OCH2CF3-3-Py], [2876: 5-CF3-6-OCH2CF3-3-Py], [2877: 2-CN-6-OCH. 2CF3-3-Py], [2878: 4-CN-6-OCH2CF3-3-Py], [2879: 5-CN-6-OCH2CF3-3-Py], [2880: 2-OMe-6-OCH2CF3- 3-Py], [2881: 4-OMe-6-OCH2CF3-3-Py], [2882: 5-OMe-6-OCH2CF3-3-Py], [2883: 2-Pr-3-Py], [ 2884: 4-Cl-2-Pr-3-Py], [2885: 5-Cl-2-Pr-3-Py], [2886: 6-Cl-2-Pr-3-Py], [2887: 4-Me-2-Pr-3-Py], [2888: 5-Me-2-Pr-3-Py], [2889: 6-Me-2-Pr-3-Py], [2890: 4- CF3-2-Pr-3-Py], [2891: 5-CF3- -Pr-3-Py], [2892: 6-CF3-2-Pr-3-Py], [2893: 4-CN-2-Pr-3-Py], [2894: 5-CN-2-Pr -3-Py], [2895: 6-CN-2-Pr-3-Py], [2896: 4-OMe-2-Pr-3-Py], [2897: 5-OMe-2-Pr-3 -Py], [2898: 6-OMe-2-Pr-3-Py], [2899: 4-Pr-3-Py], [2900: 2-Cl-4-Pr-3-Py],

[2901: 5-Cl-4-Pr-3-Py], [2902: 6-Cl-4-Pr-3-Py], [2903: 2-Me-4-Pr-3-Py], [2904] : 5-Me-4-Pr-3-Py], [2905: 6-Me-4-Pr-3-Py], [2906: 2-CF3-4-Pr-3-Py], [2907: 5 -CF3-4-Pr-3-Py], [2908: 6-CF3-4-Pr-3-Py], [2909: 2-CN-4-Pr-3-Py], [2910: 5-CN -4-Pr-3-Py], [2911: 6-CN-4-Pr-3-Py], [2912: 2-OMe-4-Pr-3-Py], [2913: 5-OMe-4 -Pr-3-Py], [2914: 6-OMe-4-Pr-3-Py], [2915: 5-Pr-3-Py], [2 16: 2-Cl-5-Pr-3-Py], [2917: 4-Cl-5-Pr-3-Py], [2918: 6-Cl-5-Pr-3-Py], [2919: 2-Me-5-Pr-3-Py], [2920: 4-Me-5-Pr-3-Py], [2921: 6-Me-5-Pr-3-Py], [2922: 2- CF3-5-Pr-3-Py], [2923: 4-CF3-5-Pr-3-Py], [2924: 6-CF3-5-Pr-3-Py], [2925: 2-CN- 5-Pr-3-Py], [2926: 4-CN-5-Pr-3-Py], [2927: 6-CN-5-Pr-3-Py], [2928: 2-OMe-5 Pr-3-Py], [2929: 4-OMe-5-Pr-3-Py], [2930: 6-OMe-5-Pr-3-Py] [2931: 6-Pr-3-Py], [2932: 2-Cl-6-Pr-3-Py], [2933: 4-Cl-6-Pr-3-Py], [2934: 5-Cl -6-Pr-3-Py], [2935: 2-Me-6-Pr-3-Py], [2936: 4-Me-6-Pr-3-Py], [2937: 5-Me-6. -Pr-3-Py], [2938: 2-CF3-6-Pr-3-Py], [2939: 4-CF3-6-Pr-3-Py], [2940: 5-CF3-6-Pr -3-Py], [2941: 2-CN-6-Pr-3-Py], [2942: 4-CN-6-Pr-3-Py], [2943: 5-CN-6-Pr-3 -Py], [2944: 2-OMe-6-Pr-3-Py], [2945: 4-OMe-6-Pr-3-Py], [29 46: 5-OMe-6-Pr-3-Py], [2947: 2-OPr-3-Py], [2948: 4-Cl-2-OPr-3-Py], [2949: 5-Cl- 2-OPr-3-Py], [2950: 6-Cl-2-OPr-3-Py], [2951: 4-Me-2-OPr-3-Py], [2952: 5-Me-2- OPr-3-Py], [2953: 6-Me-2-OPr-3-Py], [2954: 4-CF3-2-OPr-3-Py], [2955: 5-CF3-2-OPr- 3-Py], [2956: 6-CF3-2-OPr-3-Py], [2957: 4-CN-2-OPr-3-Py], [2958: 5-CN-2-OPr-3- Py], [2959: 6-CN-2-OPr-3-Py], [2960: 4-OMe-2-OP -3-Py], [2961: 5-OMe-2-OPr-3-Py], [2962: 6-OMe-2-OPr-3-Py], [2963: 4-OPr-3-Py], [2964: 2-Cl-4-OPr-3-Py], [2965: 5-Cl-4-OPr-3-Py], [2966: 6-Cl-4-OPr-3-Py], [2967 : 2-Me-4-OPr-3-Py], [2968: 5-Me-4-OPr-3-Py], [2969: 6-Me-4-OPr-3-Py], [2970: 2]. -CF3-4-OPr-3-Py], [2971: 5-CF3-4-OPr-3-Py], [2972: 6-CF3-4-OPr-3-Py], [2973: 2-CN -4-OPr-3-Py], [2974: 5-CN-4-OPr-3-Py], [29 5: 6-CN-4-OPr-3-Py], [2976: 2-OMe-4-OPr-3-Py], [2777: 5-OMe-4-OPr-3-Py], [2978: 6-OMe-4-OPr-3-Py], [2979: 5-OPr-3-Py], [2980: 2-Cl-5-OPr-3-Py], [2981: 4-Cl-5 OPr-3-Py], [2982: 6-Cl-5-OPr-3-Py], [2983: 2-Me-5-OPr-3-Py], [2984: 4-Me-5-OPr- 3-Py], [2985: 6-Me-5-OPr-3-Py], [2986: 2-CF3-5-OPr-3-Py], [2987: 4-CF3-5-OPr-3- Py], [2988: 6-CF3-5-OPr-3-Py], [2989: 2-CN-5-O. Pr-3-Py], [2990: 4-CN-5-OPr-3-Py], [2991: 6-CN-5-OPr-3-Py], [2992: 2-OMe-5-OPr- 3-Py], [2993: 4-OMe-5-OPr-3-Py], [2994: 6-OMe-5-OPr-3-Py], [2995: 6-OPr-3-Py], [ 2996: 2-Cl-6-OPr-3-Py], [2997: 4-Cl-6-OPr-3-Py], [2998: 5-Cl-6-OPr-3-Py], [2999: 2-Me-6-OPr-3-Py], [3000: 4-Me-6-OPr-3-Py],

[3001: 5-Me-6-OPr-3-Py], [3002: 2-CF3-6-OPr-3-Py], [3003: 4-CF3-6-OPr-3-Py], [3004 : 5-CF3-6-OPr-3-Py], [3005: 2-CN-6-OPr-3-Py], [3006: 4-CN-6-OPr-3-Py], [3007: 5 -CN-6-OPr-3-Py], [3008: 2-OMe-6-OPr-3-Py], [3009: 4-OMe-6-OPr-3-Py], [3010: 5-OMe -6-OPr-3-Py], [3011: 2-SMe-3-Py], [3012: 4-Cl-2-SMe-3-Py], [3013: 5-Cl-2-SMe-3 -Py], [3014: 6-Cl-2-SMe-3-Py], [3015: 4-Me 2-SMe-3-Py], [3016: 5-Me-2-SMe-3-Py], [3017: 6-Me-2-SMe-3-Py], [3018: 4-CF3-2- SMe-3-Py], [3019: 5-CF3-2-SMe-3-Py], [3020: 6-CF3-2-SMe-3-Py], [3021: 4-CN-2-SMe- 3-Py], [3022: 5-CN-2-SMe-3-Py], [3023: 6-CN-2-SMe-3-Py], [3024: 4-OMe-2-SMe-3- Py], [3025: 5-OMe-2-SMe-3-Py], [3026: 6-OMe-2-SMe-3-Py], [3027: 4-SMe-3-Py], [3028: 2-Cl-4-SMe-3-Py], [3029: 5-Cl-4-SMe-3-P ], [3030: 6-Cl-4-SMe-3-Py], [3031: 2-Me-4-SMe-3-Py], [3032: 5-Me-4-SMe-3-Py], [3033: 6-Me-4-SMe-3-Py], [3034: 2-CF3-4-SMe-3-Py], [3035: 5-CF3-4-SMe-3-Py], [3036 : 6-CF3-4-SMe-3-Py], [3037: 2-CN-4-SMe-3-Py], [3038: 5-CN-4-SMe-3-Py], [3039: 6 -CN-4-SMe-3-Py], [3040: 2-OMe-4-SMe-3-Py], [3041: 5-OMe-4-SMe-3-Py], [3042: 6-OMe -4-SMe-3-Py], [3043: 5-SMe-3-Py], [3044: 2- Cl-5-SMe-3-Py], [3045: 4-Cl-5-SMe-3-Py], [3046: 6-Cl-5-SMe-3-Py], [3047: 2-Me- 5-SMe-3-Py], [3048: 4-Me-5-SMe-3-Py], [3049: 6-Me-5-SMe-3-Py], [3050: 2-CF3-5 SMe-3-Py], [3051: 4-CF3-5-SMe-3-Py], [3052: 6-CF3-5-SMe-3-Py], [3053: 2-CN-5-SMe- 3-Py], [3054: 4-CN-5-SMe-3-Py], [3055: 6-CN-5-SMe-3-Py], [3056: 2-OMe-5-SMe-3- Py], [3057: 4-OMe-5-SMe-3-Py], [3058: 6-OMe-5-5 Me-3-Py], [3059: 6-SMe-3-Py], [3060: 2-Cl-6-SMe-3-Py], [3061: 4-Cl-6-SMe-3-Py] [3062: 5-Cl-6-SMe-3-Py], [3063: 2-Me-6-SMe-3-Py], [3064: 4-Me-6-SMe-3-Py], [ 3065: 5-Me-6-SMe-3-Py], [3066: 2-CF3-6-SMe-3-Py], [3067: 4-CF3-6-SMe-3-Py], [3068: 5-CF3-6-SMe-3-Py], [3069: 2-CN-6-SMe-3-Py], [3070: 4-CN-6-SMe-3-Py], [3071: 5- CN-6-SMe-3-Py], [3072: 2-OMe-6-SMe-3-Py], [3 73: 4-OMe-6-SMe-3-Py], [3074: 5-OMe-6-SMe-3-Py], [3075: 2-SCF3-3-Py], [3076: 4-Cl- 2-SCF3-3-Py], [3077: 5-Cl-2-SCF3-3-Py], [3078: 6-Cl-2-SCF3-3-Py], [3079: 4-Me-2- SCF3-3-Py], [3080: 5-Me-2-SCF3-3-Py], [3081: 6-Me-2-SCF3-3-Py], [3082: 4-CF3-2-SCF3- 3-Py], [3083: 5-CF3-2-SCF3-3-Py], [3084: 6-CF3-2-SCF3-3-Py], [3085: 4-CN-2-SCF3-3 Py], [3086: 5-CN-2-SCF3-3-Py], [3 087: 6-CN-2-SCF3-3-Py], [3088: 4-OMe-2-SCF3-3-Py], [3089: 5-OMe-2-SCF3-3-Py], [3090: 6-OMe-2-SCF3-3-Py], [3091: 4-SCF3-3-Py], [3092: 2-Cl-4-SCF3-3-Py], [3093: 5-Cl-4- SCF3-3-Py], [3094: 6-Cl-4-SCF3-3-Py], [3095: 2-Me-4-SCF3-3-Py], [3096: 5-Me-4-SCF3- 3-Py], [3097: 6-Me-4-SCF3-3-Py], [3098: 2-CF3-4-SCF3-3-Py], [3099: 5-CF3-4-SCF3-3 Py], [3100: 6-CF3-4-SCF3-3-Py ,

[3101: 2-CN-4-SCF3-3-Py], [3102: 5-CN-4-SCF3-3-Py], [3103: 6-CN-4-SCF3-3-Py], [3104 : 2-OMe-4-SCF3-3-Py], [3105: 5-OMe-4-SCF3-3-Py], [3106: 6-OMe-4-SCF3-3-Py], [3107: 5 -SCF3-3-Py], [3108: 2-Cl-5-SCF3-3-Py], [3109: 4-Cl-5-SCF3-3-Py], [3110: 6-Cl-5-SCF3 -3-Py], [3111: 2-Me-5-SCF3-3-Py], [3112: 4-Me-5-SCF3-3-Py], [3113: 6-Me-5-SCF3-3 -Py], [3114: 2-CF3-5-SCF3-3-Py [3115: 4-CF3-5-SCF3-3-Py], [3116: 6-CF3-5-SCF3-3-Py], [3117: 2-CN-5-SCF3-3-Py], [ 3118: 4-CN-5-SCF3-3-Py], [3119: 6-CN-5-SCF3-3-Py], [3120: 2-OMe-5-SCF3-3-Py], [3121: 4-OMe-5-SCF3-3-Py], [3122: 6-OMe-5-SCF3-3-Py], [3123: 6-SCF3-3-Py], [3124: 2-Cl-6 SCF3-3-Py], [3125: 4-Cl-6-SCF3-3-Py], [3126: 6-Cl-6-SCF3-3-Py], [3127: 2-Me-6-SCF3- 3-Py], [3128: 4-Me-6-SCF3-3 Py], [3129: 6-Me-6-SCF3-3-Py], [3130: 2-CF3-6-SCF3-3-Py], [3131: 4-CF3-6-SCF3-3-Py] [3132: 6-CF3-6-SCF3-3-Py], [3133: 2-CN-6-SCF3-3-Py], [3134: 4-CN-6-SCF3-3-Py], [ 3135: 6-CN-6-SCF3-3-Py], [3136: 2-OMe-6-SCF3-3-Py], [3137: 4-OMe-6-SCF3-3-Py], [3138: 6-OMe-6-SCF3-3-Py], [3139: 2-S (O) Me-3-Py], [3140: 4-Cl-2-S (O) Me-3-Py], [ 3141: 5-Cl-2-S (O) Me-3-Py], [3142: 6-Cl -2 -S (O) Me-3-Py], [3143: 4-Me-2-S (O) Me-3-Py], [3144: 5-Me-2-S (O) Me-3 -Py], [3145: 6-Me-2-S (O) Me-3-Py], [3146: 4-CF3-2-S (O) Me-3-Py], [3147: 5-CF3. -2-S (O) Me-3-Py], [3148: 6-CF3-2-S (O) Me-3-Py], [3149: 4-CN-2-S (O) Me-3 -Py], [3150: 5-CN-2-S (O) Me-3-Py], [3151: 6-CN-2-S (O) Me-3-Py], [3152: 4-OMe. -2-S (O) Me-3-Py], [3153: 5-OMe-2-S (O) Me-3-Py], [3154: 6-OMe-2-S (O) Me-3 -Py] [3155: 4-S (O) Me-3-Py], [3156: 2-Cl-4-S (O) Me-3-Py], [3157: 5-Cl-4-S (O) Me -3-Py], [3158: 6-Cl-4-S (O) Me-3-Py], [3159: 2-Me-4-S (O) Me-3-Py], [3160: 5 -Me-4-S (O) Me-3-Py], [3161: 6-Me-4-S (O) Me-3-Py], [3162: 2-CF3-4-S (O) Me -3-Py], [3163: 5-CF3-4-S (O) Me-3-Py], [3164: 6-CF3-4-S (O) Me-3-Py], [3165: 2 -CN-4-S (O) Me-3-Py], [3166: 5-CN-4-S (O) Me-3-Py], [3167: 6-CN-4-S (O) Me -3- y], [3168: 2-OMe-4-S (O) Me-3-Py], [3169: 5-OMe-4-S (O) Me-3-Py], [3170: 6-OMe- 4-S (O) Me-3-Py], [3171: 5-S (O) Me-3-Py], [3172: 2-Cl-5-S (O) Me-3-Py], [ 3173: 4-Cl-5-S (O) Me-3-Py], [3174: 6-Cl-5-S (O) Me-3-Py], [3175: 2-Me-5-S ( O) Me-3-Py], [3176: 4-Me-5-S (O) Me-3-Py], [3177: 6-Me-5-S (O) Me-3-Py], [ 3178: 2-CF3-5-S (O) Me-3-Py], [3179: 4-CF3-5-S (O) Me-3-Py], [3180: 6-CF3-5-S ( O) Me-3-Py], [3181: 2-CN-5-S (O) Me-3-Py], [3182: 4-CN-5-S (O) Me-3-Py], [3183: 6-CN-5-S (O) Me-3-Py], [3184: 2-OMe-5-S (O) Me-3-Py], [3185: 4-OMe-5-S (O) Me-3-Py], [3186: 6-OMe-5-S (O) Me-3-Py], [3187: 6-S (O) Me-3-Py], [3188: 2-Cl- 6-S (O) Me-3-Py], [3189: 4-Cl-6-S (O) Me-3-Py], [3190: 5-Cl-6-S (O) Me-3- Py], [3191: 2-Me-6-S (O) Me-3-Py], [3192: 4-Me-6-S (O) Me-3-Py], [3193: 5-Me- 6-S O) Me-3-Py], [3194: 2-CF3-6-S (O) Me-3-Py], [3195: 4-CF3-6-S (O) Me-3-Py], [ 3196: 5-CF3-6-S (O) Me-3-Py], [3197: 2-CN-6-S (O) Me-3-Py], [3198: 4-CN-6-S ( O) Me-3-Py], [3199: 5-CN-6-S (O) Me-3-Py], [3200: 2-OMe-6-S (O) Me-3-Py],

[3201: 4-OMe-6-S (O) Me-3-Py], [3202: 5-OMe-6-S (O) Me-3-Py], [3203: 2-S (O) CF3 -3-Py], [3204: 4-Cl-2-S (O) CF3-3-Py], [3205: 5-Cl-2-S (O) CF3-3-Py], [3206: 6 -Cl-2-S (O) CF3-3-Py], [3207: 4-Me-2-S (O) CF3-3-Py], [3208: 5-Me-2-S (O) CF3 -3-Py], [3209: 6-Me-2-S (O) CF3-3-Py], [3210: 4-CF3-2-S (O) CF3-3-Py], [3211: 5 -CF3-2-S (O) CF3-3-Py], [3212: 6-CF3-2-S (O) CF3-3-Py], [3213: 4-CN- -S (O) CF3-3-Py], [3214: 5-CN-2-S (O) CF3-3-Py], [3215: 6-CN-2-S (O) CF3-3-Py ], [3216: 4-OMe-2-S (O) CF3-3-Py], [3217: 5-OMe-2-S (O) CF3-3-Py], [3218: 6-OMe-2 -S (O) CF3-3-Py], [3219: 4-S (O) CF3-3-Py], [3220: 2-Cl-4-S (O) CF3-3-Py], [3221 : 5-Cl-4-S (O) CF3-3-Py], [3222: 6-Cl-4-S (O) CF3-3-Py], [3223: 2-Me-4-S (O ) CF3-3-Py], [3224: 5-Me-4-S (O) CF3-3-Py], [3225: 6-Me-4-S (O) CF3-3. Py], [3226: 2-CF3-4-S (O) CF3-3-Py], [3227: 5-CF3-4-S (O) CF3-3-Py], [3228: 6-CF3- 4-S (O) CF3-3-Py], [3229: 2-CN-4-S (O) CF3-3-Py], [3230: 5-CN-4-S (O) CF3-3- Py], [3231: 6-CN-4-S (O) CF3-3-Py], [3232: 2-OMe-4-S (O) CF3-3-Py], [3233: 5-OMe- 4-S (O) CF3-3-Py], [3234: 6-OMe-4-S (O) CF3-3-Py], [3235: 5-S (O) CF3-3-Py], [ 3236: 2-Cl-5-S (O) CF3-3-Py], [3237: 4-Cl-5-S (O) CF3-3-Py], [323 8: 6-Cl-5-S (O) CF3-3-Py], [3239: 2-Me-5-S (O) CF3-3-Py], [3240: 4-Me-5-S ( O) CF3-3-Py], [3241: 6-Me-5-S (O) CF3-3-Py], [3242: 2-CF3-5-S (O) CF3-3-Py], [ 3243: 4-CF3-5-S (O) CF3-3-Py], [3244: 6-CF3-5-S (O) CF3-3-Py], [3245: 2-CN-5-S ( O) CF3-3-Py], [3246: 4-CN-5-S (O) CF3-3-Py], [3247: 6-CN-5-S (O) CF3-3-Py], [ 3248: 2-OMe-5-S (O) CF3-3-Py], [3249: 4-OMe-5-S (O) CF3-3-Py], [3250: 6- Me-5-S (O) CF3-3-Py], [3251: 6-S (O) CF3-3-Py], [3252: 2-Cl-6-S (O) CF3-3-Py] [3253: 4-Cl-6-S (O) CF3-3-Py], [3254: 5-Cl-6-S (O) CF3-3-Py], [3255: 2-Me-6-6. S (O) CF3-3-Py], [3256: 4-Me-6-S (O) CF3-3-Py], [3257: 5-Me-6-S (O) CF3-3-Py] [3258: 2-CF3-6-S (O) CF3-3-Py], [3259: 4-CF3-6-S (O) CF3-3-Py], [3260: 5-CF3-6 S (O) CF3-3-Py], [3261: 2-CN-6-S (O) CF3-3-Py], [3262: 4-CN-6-S (O) C 3-3-3-Py], [3263: 5-CN-6-S (O) CF3-3-Py], [3264: 2-OMe-6-S (O) CF3-3-Py], [3265: 4-OMe-6-S (O) CF3-3-Py], [3266: 5-OMe-6-S (O) CF3-3-Py], [3267: 2-S (O) 2Me-3- Py], [3268: 4-Cl-2-S (O) 2Me-3-Py], [3269: 5-Cl-2-S (O) 2Me-3-Py], [3270: 6-Cl- 2-S (O) 2Me-3-Py], [3271: 4-Me-2-S (O) 2Me-3-Py], [3272: 5-Me-2-S (O) 2Me-3- Py], [3273: 6-Me-2-S (O) 2Me-3-Py], [3274: 4-CF3-2-S (O) 2Me-3-Py], [3 275: 5-CF3-2-S (O) 2Me-3-Py], [3276: 6-CF3-2-S (O) 2Me-3-Py], [3277: 4-CN-2-S ( O) 2Me-3-Py], [3278: 5-CN-2-S (O) 2Me-3-Py], [3279: 6-CN-2-S (O) 2Me-3-Py], [ 3280: 4-OMe-2-S (O) 2Me-3-Py], [3281: 5-OMe-2-S (O) 2Me-3-Py], [3282: 6-OMe-2-S ( O) 2Me-3-Py], [3283: 4-S (O) 2Me-3-Py], [3284: 2-Cl-4-S (O) 2Me-3-Py], [3285: 5- Cl-4-S (O) 2Me-3-Py], [3286: 6-Cl-4-S (O) 2Me-3-Py], [3287: 2-Me- -S (O) 2Me-3-Py], [3288: 5-Me-4-S (O) 2Me-3-Py], [3289: 6-Me-4-S (O) 2Me-3-Py ], [3290: 2-CF3-4-S (O) 2Me-3-Py], [3291: 5-CF3-4-S (O) 2Me-3-Py], [3292: 6-CF3-4]. -S (O) 2Me-3-Py], [3293: 2-CN-4-S (O) 2Me-3-Py], [3294: 5-CN-4-S (O) 2Me-3-Py ], [3295: 6-CN-4-S (O) 2Me-3-Py], [3296: 2-OMe-4-S (O) 2Me-3-Py], [3297: 5-OMe-4 -S (O) 2Me-3-Py], [3298: 6-OMe-4-S (O) 2Me-3-Py], [3299: 5-S (O) 2M -3-Py], [3300: 2-Cl-5-S (O) 2Me-3-Py],

[3301: 4-Cl-5-S (O) 2Me-3-Py], [3302: 6-Cl-5-S (O) 2Me-3-Py], [3303: 2-Me-5-S (O) 2Me-3-Py], [3304: 4-Me-5-S (O) 2Me-3-Py], [3305: 6-Me-5-S (O) 2Me-3-Py], [3306: 2-CF3-5-S (O) 2Me-3-Py], [3307: 4-CF3-5-S (O) 2Me-3-Py], [3308: 6-CF3-5-S (O) 2Me-3-Py], [3309: 2-CN-5-S (O) 2Me-3-Py], [3310: 4-CN-5-S (O) 2Me-3-Py], [3311: 6-CN-5-S (O) 2Me-3-Py], [3312: 2-OMe-5-S (O) 2Me-3-Py], [3313 4-OMe-5-S (O) 2Me-3-Py], [3314: 6-OMe-5-S (O) 2Me-3-Py], [3315: 6-S (O) 2Me-3- Py], [3316: 2-Cl-6-S (O) 2Me-3-Py], [3317: 4-Cl-6-S (O) 2Me-3-Py], [3318: 5-Cl- 6-S (O) 2Me-3-Py], [3319: 2-Me-6-S (O) 2Me-3-Py], [3320: 4-Me-6-S (O) 2Me-3- Py], [3321: 5-Me-6-S (O) 2Me-3-Py], [3322: 2-CF3-6-S (O) 2Me-3-Py], [3323: 4-CF3- 6-S (O) 2Me-3-Py], [3324: 5-CF3-6-S (O) 2Me-3-Py], [3325: 2-CN-6-S O) 2Me-3-Py], [3326: 4-CN-6-S (O) 2Me-3-Py], [3327: 5-CN-6-S (O) 2Me-3-Py], [ 3328: 2-OMe-6-S (O) 2Me-3-Py], [3329: 4-OMe-6-S (O) 2Me-3-Py], [3330: 5-OMe-6-S ( O) 2Me-3-Py], [3331: 2-S (O) 2CF3-3-Py], [3332: 4-Cl-2-S (O) 2CF3-3-Py], [3333: 5- Cl-2-S (O) 2CF3-3-Py], [3334: 6-Cl-2-S (O) 2CF3-3-Py], [3335: 4-Me-2-S (O) 2CF3- 3-Py], [3336: 5-Me-2-S (O) 2CF3-3-Py], [3337: 6-Me-2-S (O) 2CF 3-3-Py], [3338: 4-CF3-2-S (O) 2CF3-3-Py], [3339: 5-CF3-2-S (O) 2CF3-3-Py], [3340: 6-CF3-2-S (O) 2CF3-3-Py], [3341: 4-CN-2-S (O) 2CF3-3-Py], [3342: 5-CN-2-S (O) 2CF3-3-Py], [3343: 6-CN-2-S (O) 2CF3-3-Py], [3344: 4-OMe-2-S (O) 2CF3-3-Py], [3345: 5-OMe-2-S (O) 2CF3-3-Py], [3346: 6-OMe-2-S (O) 2CF3-3-Py], [3347: 4-S (O) 2CF3-3 Py], [3348: 2-Cl-4-S (O) 2CF3-3-Py], [3349: 5-Cl-4-S (O 2CF3-3-Py], [3350: 6-Cl-4-S (O) 2CF3-3-Py], [3351: 2-Me-4-S (O) 2CF3-3-Py], [3352: 5-Me-4-S (O) 2CF3-3-Py], [3353: 6-Me-4-S (O) 2CF3-3-Py], [3354: 2-CF3-4-S (O) 2CF3-3-Py], [3355: 5-CF3-4-S (O) 2CF3-3-Py], [3356: 6-CF3-4-S (O) 2CF3-3-Py], [3357: 2-CN-4-S (O) 2CF3-3-Py], [3358: 5-CN-4-S (O) 2CF3-3-Py], [3359: 6-CN-4-S (O) 2CF3-3-Py], [3360: 2-OMe-4-S (O) 2CF3-3-Py], [3361: 5-O e-4-S (O) 2CF3-3-Py], [3362: 6-OMe-4-S (O) 2CF3-3-Py], [3363: 5-S (O) 2CF3-3-Py] [3364: 2-Cl-5-S (O) 2CF3-3-Py], [3365: 4-Cl-5-S (O) 2CF3-3-Py], [3366: 6-Cl-5- S (O) 2CF3-3-Py], [3367: 2-Me-5-S (O) 2CF3-3-Py], [3368: 4-Me-5-S (O) 2CF3-3-Py] [3369: 6-Me-5-S (O) 2CF3-3-Py], [3370: 2-CF3-5-S (O) 2CF3-3-Py], [3371: 4-CF3-5 S (O) 2CF3-3-Py], [3372: 6-CF3-5-S (O) 2CF3-3-Py], [3373: 2 -CN-5-S (O) 2CF3-3-Py], [3374: 4-CN-5-S (O) 2CF3-3-Py], [3375: 6-CN-5-S (O) 2CF3 -3-Py], [3376: 2-OMe-5-S (O) 2CF3-3-Py], [3377: 4-OMe-5-S (O) 2CF3-3-Py], [3378: 6. -OMe-5-S (O) 2CF3-3-Py], [3379: 6-S (O) 2CF3-3-Py], [3380: 2-Cl-6-S (O) 2CF3-3-Py ], [3381: 4-Cl-6-S (O) 2CF3-3-Py], [3382: 5-Cl-6-S (O) 2CF3-3-Py], [3383: 2-Me-6. -S (O) 2CF3-3-Py], [3384: 4-Me-6-S (O) 2CF3-3-Py], [3385: -Me-6-S (O) 2CF3-3-Py], [3386: 2-CF3-6-S (O) 2CF3-3-Py], [3387: 4-CF3-6-S (O) 2CF3 -3-Py], [3388: 5-CF3-6-S (O) 2CF3-3-Py], [3389: 2-CN-6-S (O) 2CF3-3-Py], [3390: 4 -CN-6-S (O) 2CF3-3-Py], [3391: 5-CN-6-S (O) 2CF3-3-Py], [3392: 2-OMe-6-S (O) 2CF3 -3-Py], [3393: 4-OMe-6-S (O) 2CF3-3-Py], [3394: 5-OMe-6-S (O) 2CF3-3-Py]
[3395: 2-CN-3-Py], [3396: 4-Cl-2-CN-3-Py], [397: 5-Cl-2-CN-3-Py], [3398: 6-Cl -2-CN-3-Py], [3399: 4-Me-2-CN-3-Py], [3400: 5-Me-2-CN-3-Py],

[3401: 6-Me-2-CN-3-Py], [3402: 4-CF3-2-CN-3-Py], [3403: 5-CF3-2-CN-3-Py], [3404 : 6-CF3-2-CN-3-Py], [3405: 4-CN-2-CN-3-Py], [3406: 5-CN-2-CN-3-Py], [3407: 6 -CN-2-CN-3-Py], [3408: 4-OMe-2-CN-3-Py], [3409: 5-OMe-2-CN-3-Py], [3410: 6-OMe -2-CN-3-Py], [3411: 4-CN-3-Py], [3412: 2-Cl-4-CN-3-Py], [3413: 5-Cl-4-CN-3 -Py], [3414: 6-Cl-4-CN-3-Py], [3415: 2-Me-4-CN-3-Py], [3 16: 5-Me-4-CN-3-Py], [3417: 6-Me-4-CN-3-Py], [3418: 2-CF3-4-CN-3-Py], [3419: 5-CF3-4-CN-3-Py], [3420: 6-CF3-4-CN-3-Py], [3421: 2-CN-4-CN-3-Py], [3422: 5- CN-4-CN-3-Py], [3423: 6-CN-4-CN-3-Py], [3424: 2-OMe-4-CN-3-Py], [3425: 5-OMe- 4-CN-3-Py], [3426: 6-OMe-4-CN-3-Py], [3427: 5-CN-3-Py], [3428: 2-Cl-5-CN-3- Py], [3429: 4-Cl-5-CN-3-Py], [3430: 6-Cl-5-CN-3-Py], [343 : 2-Me-5-CN-3-Py], [3432: 4-Me-5-CN-3-Py], [3433: 6-Me-5-CN-3-Py], [3434: 2] -CF3-5-CN-3-Py], [3435: 4-CF3-5-CN-3-Py], [3436: 6-CF3-5-CN-3-Py], [3437: 2-CN -5-CN-3-Py], [3438: 4-CN-5-CN-3-Py], [3439: 6-CN-5-CN-3-Py], [3440: 2-OMe-5. -CN-3-Py], [3441: 4-OMe-5-CN-3-Py], [3442: 6-OMe-5-CN-3-Py], [3443: 6-CN-3-Py] ], [3444: 2-Cl-6-CN-3-Py], [3445: 4-Cl-6-CN-3-Py], [3446: 5 -Cl-6-CN-3-Py], [3447: 2-Me-6-CN-3-Py], [3448: 4-Me-6-CN-3-Py], [3449: 5-Me -6-CN-3-Py], [3450: 2-CF3-6-CN-3-Py], [3451: 4-CF3-6-CN-3-Py], [3452: 5-CF3-6 -CN-3-Py], [3453: 2-CN-6-CN-3-Py], [3454: 4-CN-6-CN-3-Py], [3455: 5-CN-6-CN -3-Py], [3456: 2-OMe-6-CN-3-Py], [3457: 4-OMe-6-CN-3-Py], [3458: 5-OMe-6-CN-3 -Py], [3459: 2-COOMe-3-Py], [3460: 4-Cl-2-COOMe-3-Py], [34 1: 5-Cl-2-COOMe-3-Py], [3462: 6-Cl-2-COOMe-3-Py], [3463: 4-Me-2-COOMe-3-Py], [3464: 5-Me-2-COOMe-3-Py], [3465: 6-Me-2-COOMe-3-Py], [3466: 4-CF3-2-COOMe-3-Py], [3467: 5- CF3-2-COOMe-3-Py], [3468: 6-CF3-2-COOMe-3-Py], [3469: 4-CN-2-COOMe-3-Py], [3470: 5-CN- 2-COOMe-3-Py], [3471: 6-CN-2-COOMe-3-Py], [3472: 4-OMe-2-COOMe-3-Py], [3473: 5-OMe-2- COOMe-3-Py], [3474: -OMe-2-COOMe-3-Py], [3475: 4-COOMe-3-Py], [3476: 2-Cl-4-COOMe-3-Py], [3477: 5-Cl-4-COOMe -3-Py], [3478: 6-Cl-4-COOMe-3-Py], [3479: 2-Me-4-COOMe-3-Py], [3480: 5-Me-4-COOMe-3 -Py], [3481: 6-Me-4-COOMe-3-Py], [3482: 2-CF3-4-COOMe-3-Py], [3483: 5-CF3-4-COOMe-3-Py ], [3484: 6-CF3-4-COOMe-3-Py], [3485: 2-CN-4-COOMe-3-Py], [3486: 5-CN-4-COOMe-3-Py], [3487: 6-CN-4-COO Me-3-Py], [3488: 2-OMe-4-COOMe-3-Py], [3289: 5-OMe-4-COOMe-3-Py], [3490: 6-OMe-4-COOMe- 3-Py], [3491: 5-COOMe-3-Py], [3492: 2-Cl-5-COOMe-3-Py], [3493: 4-Cl-5-COOMe-3-Py], [ 3494: 6-Cl-5-COOMe-3-Py], [3495: 2-Me-5-COOMe-3-Py], [3496: 4-Me-5-COOMe-3-Py], [3497: 6-Me-5-COOMe-3-Py], [3498: 2-CF3-5-COOMe-3-Py], [3499: 4-CF3-5-COOMe-3-Py], [3500: 6- CF3-5-COOMe-3-Py ,

[3501: 2-CN-5-COOMe-3-Py], [3502: 4-CN-5-COOMe-3-Py], [3503: 6-CN-5-COOMe-3-Py], [3504 : 2-OMe-5-COOMe-3-Py], [3505: 4-OMe-5-COOMe-3-Py], [3506: 6-OMe-5-COOMe-3-Py], [3507: 6 -COOMe-3-Py], [3508: 2-Cl-6-COOMe-3-Py], [3509: 4-Cl-6-COOMe-3-Py], [3510: 5-Cl-6-COOMe -3-Py], [3511: 2-Me-6-COOMe-3-Py], [3512: 4-Me-6-COOMe-3-Py], [3513: 5-Me-6-COOMe-3. -Py], [3514: 2-CF -6-COOMe-3-Py], [3515: 4-CF3-6-COOMe-3-Py], [3516: 5-CF3-6-COOMe-3-Py], [3517: 2-CN-6 -COOMe-3-Py], [3518: 4-CN-6-COOMe-3-Py], [3519: 5-CN-6-COOMe-3-Py], [3520: 2-OMe-6-COOMe -3-Py], [3521: 4-OMe-6-COOMe-3-Py], [3522: 5-OMe-6-COOMe-3-Py], [3523: 2-NO2-3-Py], [3524: 4-Cl-2-NO2-3-Py], [3525: 5-Cl-2-NO2-3-Py], [3526: 6-Cl-2-NO2-3-Py], [3527 : 4-Me-2-NO2-3-Py], [3 28: 5-Me-2-NO2-3-Py], [3529: 6-Me-2-NO2-3-Py], [3530: 4-CF3-2-NO2-3-Py], [3531: 5-CF3-2-NO2-3-Py], [3532: 6-CF3-2-NO2-3-Py], [3533: 4-CN-2-NO2-3-Py], [3534: 5- CN-2-NO2-3-Py], [3535: 6-CN-2-NO2-3-Py], [3536: 4-OMe-2-NO2-3-Py], [3537: 5-OMe- 2-NO2-3-Py], [3538: 6-OMe-2-NO2-3-Py], [3539: 4-NO2-3-Py], [3540: 2-Cl-4-NO2-3- Py], [3541: 5-Cl-4-NO2-3-Py], [3542: 6-Cl-4- NO2-3-Py], [3543: 2-Me-4-NO2-3-Py], [3544: 5-Me-4-NO2-3-Py], [3545: 6-Me-4-NO2- 3-Py], [3546: 2-CF3-4-NO2-3-Py], [3547: 5-CF3-4-NO2-3-Py], [3548: 6-CF3-4-NO2-3- Py], [3549: 2-CN-4-NO2-3-Py], [3550: 5-CN-4-NO2-3-Py], [3551: 6-CN-4-NO2-3-Py] [3552: 2-OMe-4-NO2-3-Py], [3553: 5-OMe-4-NO2-3-Py], [3554: 6-OMe-4-NO2-3-Py], [ 3555: 5-NO2-3-Py], [3556: 2-Cl-5-NO2-3-Py], 3557: 4-Cl-5-NO2-3-Py], [3558: 6-Cl-5-NO2-3-Py], [3559: 2-Me-5-NO2-3-Py], [3560: 4-Me-5-NO2-3-Py], [3561: 6-Me-5-NO2-3-Py], [3562: 2-CF3-5-NO2-3-Py], [3563: 4- CF3-5-NO2-3-Py], [3564: 6-CF3-5-NO2-3-Py], [3565: 2-CN-5-NO2-3-Py], [3566: 4-CN- 5-NO2-3-Py], [3567: 6-CN-5-NO2-3-Py], [3568: 2-OMe-5-NO2-3-Py], [3569: 4-OMe-5 NO2-3-Py], [3570: 6-OMe-5-NO2-3-Py], [3571 6-NO2-3-Py], [3572: 2-Cl-6-NO2-3-Py], [3573: 4-Cl-6-NO2-3-Py], [3574: 5-Cl-6 NO2-3-Py], [3575: 2-Me-6-NO2-3-Py], [3576: 4-Me-6-NO2-3-Py], [3577: 5-Me-6-NO2- 3-Py], [3578: 2-CF3-6-NO2-3-Py], [3579: 4-CF3-6-NO2-3-Py], [3580: 5-CF3-6-NO2-3- Py], [3581: 2-CN-6-NO2-3-Py], [3582: 4-CN-6-NO2-3-Py], [3583: 5-CN-6-NO2-3-Py] [3584: 2-OMe-6-NO2-3-Py], [3585: 4-OMe-6-NO2- 3-Py], [3586: 5-OMe-6-NO2-3-Py], [3587: 2-NH2-3-Py], [3588: 4-Cl-2-NH2-3-Py], [ 3589: 5-Cl-2-NH2-3-Py], [3590: 6-Cl-2-NH2-3-Py], [3591: 4-Me-2-NH2-3-Py], [3592: 5-Me-2-NH2-3-Py], [3593: 6-Me-2-NH2-3-Py], [3594: 4-CF3-2-NH2-3-Py], [3595: 5- CF3-2-NH2-3-Py], [3596: 6-CF3-2-NH2-3-Py], [3597: 4-CN-2-NH2-3-Py], [3598: 5-CN- 2-NH2-3-Py], [3599: 6-CN-2-NH2-3-Py], [3600: -OMe-2-NH2-3-Py],

[3601: 5-OMe-2-NH2-3-Py], [3602: 6-OMe-2-NH2-3-Py], [3603: 4-NH2-3-Py], [3604: 2-Cl -4-NH2-3-Py], [3605: 5-Cl-4-NH2-3-Py], [3606: 6-Cl-4-NH2-3-Py], [3607: 2-Me-4 -NH2-3-Py], [3608: 5-Me-4-NH2-3-Py], [3609: 6-Me-4-NH2-3-Py], [3610: 2-CF3-4-NH2 -3-Py], [3611: 5-CF3-4-NH2-3-Py], [3612: 6-CF3-4-NH2-3-Py], [3613: 2-CN-4-NH2-3 -Py], [3614: 5-CN-4-NH2-3-Py], [3615: 6-CN- -NH2-3-Py], [3616: 2-OMe-4-NH2-3-Py], [3617: 5-OMe-4-NH2-3-Py], [3618: 6-OMe-4-NH2 -3-Py], [3619: 5-NH2-3-Py], [3620: 2-Cl-5-NH2-3-Py], [3621: 4-Cl-5-NH2-3-Py], [3622: 6-Cl-5-NH2-3-Py], [3623: 2-Me-5-NH2-3-Py], [3624: 4-Me-5-NH2-3-Py], [3625 : 6-Me-5-NH2-3-Py], [3626: 2-CF3-5-NH2-3-Py], [3627: 4-CF3-5-NH2-3-Py], [3628: 6 -CF3-5-NH2-3-Py], [3629: 2-CN-5-NH2-3-Py [3630: 4-CN-5-NH2-3-Py], [3631: 6-CN-5-NH2-3-Py], [3632: 2-OMe-5-NH2-3-Py], [ 3633: 4-OMe-5-NH2-3-Py], [3634: 6-OMe-5-NH2-3-Py], [3635: 6-NH2-3-Py], [3636: 2-Cl- 6-NH2-3-Py], [3637: 4-Cl-6-NH2-3-Py], [3638: 5-Cl-6-NH2-3-Py], [3639: 2-Me-6-6 NH2-3-Py], [3640: 4-Me-6-NH2-3-Py], [3641: 5-Me-6-NH2-3-Py], [3642: 2-CF3-6-NH2- 3-Py], [3643: 4-CF3-6-NH2-3-Py], [3644: 5-CF 3-6-NH2-3-Py], [3645: 2-CN-6-NH2-3-Py], [3646: 4-CN-6-NH2-3-Py], [3647: 5-CN- 6-NH2-3-Py], [3648: 2-OMe-6-NH2-3-Py], [3649: 4-OMe-6-NH2-3-Py], [3650: 5-OMe-6 NH2-3-Py], [3651: 2-NHMe-3-Py], [3652: 4-Cl-2-NHMe-3-Py], [3653: 5-Cl-2-NHMe-3-Py] [3654: 6-Cl-2-NHMe-3-Py], [3655: 4-Me-2-NHMe-3-Py], [3656: 5-Me-2-NHMe-3-Py], [ 3657: 6-Me-2-NHMe-3-Py], [3658: 4-CF3-2-N Me-3-Py], [3659: 5-CF3-2-NHMe-3-Py], [3660: 6-CF3-2-NHMe-3-Py], [3661: 4-CN-2-NHMe- 3-Py], [3662: 5-CN-2-NHMe-3-Py], [3663: 6-CN-2-NHMe-3-Py], [3664: 4-OMe-2-NHMe-3- Py], [3665: 5-OMe-2-NHMe-3-Py], [3666: 6-OMe-2-NHMe-3-Py], [3667: 4-NHMe-3-Py], [3668: 2-Cl-4-NHMe-3-Py], [3669: 5-Cl-4-NHMe-3-Py], [3670: 6-Cl-4-MHMe-3-Py], [3671: 2- Me-4-NHMe-3-Py], [3672: 5-Me- -NHMe-3-Py], [3673: 6-Me-4-NHMe-3-Py], [3674: 2-CF3-4-NHMe-3-Py], [3675: 5-CF3-4-NHMe -3-Py], [3676: 6-CF3-4-NHMe-3-Py], [3777: 2-CN-4-NHMe-3-Py], [3678: 5-CN-4-NHMe-3 -Py], [3679: 6-CN-4-NHMe-3-Py], [3680: 2-OMe-4-NHMe-3-Py], [3681: 5-OMe-4-NHMe-3-Py ], [3682: 6-OMe-4-NHMe-3-Py], [3683: 5-NHMe-3-Py], [3684: 2-Cl-5-NHMe-3-Py], [3685: 4] -Cl-5-NHMe-3-Py], [3686: 6- Cl-5-NHMe-3-Py], [3687: 2-Me-5-NHMe-3-Py], [3688: 4-Me-5-NHMe-3-Py], [3687: 6-Me- 5-NHMe-3-Py], [3690: 2-CF3-5-NHMe-3-Py], [3691: 4-CF3-5-NHMe-3-Py], [3692: 6-CF3-5 NHMe-3-Py], [3693: 2-CN-5-NHMe-3-Py], [3694: 4-CN-5-NHMe-3-Py], [3695: 6-CN-5-NHMe- 3-Py], [3696: 2-OMe-5-MHMe-3-Py], [3697: 4-OMe-5-NHMe-3-Py], [3698: 6-OMe-5-NHMe-3- Py], [3699: 6-NHMe-3-Py], [370 : 2-Cl-6-NHMe-3-Py],

[3701: 4-Cl-6-NHMe-3-Py], [3702: 5-Cl-6-NHMe-3-Py], [3703: 2-Me-6-NHMe-3-Py], [3704 : 4-Me-6-NHMe-3-Py], [3705: 5-Me-6-NHMe-3-Py], [3706: 2-CF3-6-NHMe-3-Py], [3707: 4 -CF3-6-NHMe-3-Py], [3708: 5-CF3-6-NHMe-3-Py], [3709: 2-CN-6-NHMe-3-Py], [3710: 4-CN -6-NHMe-3-Py], [3711: 5-CN-6-NHMe-3-Py], [3712: 2-OMe-6-NHMe-3-Py], [3713: 4-OMe-6 -NHMe-3-Py], [3714: 5-OMe-6-NH e-3-Py], [3715: 2-NMe2-3-Py], [3716: 4-Cl-2-NMe2-3-Py], [3717: 5-Cl-2-NMe2-3-Py] [3718: 6-Cl-2-NMe2-3-Py], [3719: 4-Me-2-NMe2-3-Py], [3720: 5-Me-2-NMe2-3-Py], [ 3721: 6-Me-2-NMe2-3-Py], [3722: 4-CF3-2-NMe2-3-Py], [3723: 5-CF3-2-NMe2-3-Py], [3724: 6-CF3-2-NMe2-3-Py], [3725: 4-CN-2-NMe2-3-Py], [3726: 5-CN-2-NMe2-3-Py], [3727: 6- CN-2-NMe2-3-Py], [3728: 4-OMe-2- Me2-3-Py], [3729: 5-OMe-2-NMe2-3-Py], [3730: 6-OMe-2-NMe2-3-Py], [3731: 4-NMe2-3-Py] [3732: 2-Cl-4-NMe2-3-Py], [3733: 5-Cl-4-NMe2-3-Py], [3734: 6-Cl-4-NMe2-3-Py], [ 3735: 2-Me-4-NMe2-3-Py], [3736: 5-Me-4-NMe2-3-Py], [3737: 6-Me-4-NMe2-3-Py], [3738: 2-CF3-4-NMe2-3-Py], [3739: 5-CF3-4-NMe2-3-Py], [3740: 6-CF3-4-NMe2-3-Py], [3741: 2- CN-4-NMe2-3-Py], [3742: 5-CN- 4-NMe2-3-Py], [3743: 6-CN-4-NMe2-3-Py], [3744: 2-OMe-4-NMe2-3-Py], [3745: 5-OMe-4- NMe2-3-Py], [3746: 6-OMe-4-NMe2-3-Py], [3747: 5-NMe2-3-Py], [3748: 2-Cl-5-NMe2-3-Py] [3749: 4-Cl-5-NMe2-3-Py], [3750: 6-Cl-5-NMe2-3-Py], [3751: 2-Me-5-NMe2-3-Py], [ 3752: 4-Me-5-NMe2-3-Py], [3753: 6-Me-5-NMe2-3-Py], [3754: 2-CF3-5-NMe2-3-Py], [3755: 4-CF3-5-NMe2-3-Py], [3756: 6- F3-5-NMe2-3-Py], [3757: 2-CN-5-NMe2-3-Py], [3758: 4-CN-5-NMe2-3-Py], [3759: 6-CN- 5-NMe2-3-Py], [3760: 2-OMe-5-NMe2-3-Py], [3761: 4-OMe-5-NMe2-3-Py], [3762: 6-OMe-5 NMe2-3-Py], [3763: 6-NMe2-3-Py], [3764: 2-Cl-6-NMe2-3-Py], [3765: 4-Cl-6-NMe2-3-Py] [3766: 5-Cl-6-NMe2-3-Py], [3767: 2-Me-6-NMe2-3-Py], [3768: 4-Me-6-NMe2-3-Py], [ 3769: 5-Me-6-NMe2-3-Py], [3770: -CF3-6-NMe2-3-Py], [3771: 4-CF3-6-NMe2-3-Py], [3772: 5-CF3-6-NMe2-3-Py], [3773: 2-CN -6-NMe2-3-Py], [3774: 4-CN-6-NMe2-3-Py], [3775: 5-CN-6-NMe2-3-Py], [3776: 2-OMe-6 -NMe2-3-Py], [3777: 4-OMe-6-NMe2-3-Py], [3778: 5-OMe-6-NMe2-3-Py], [379: 2-ACNH-3-Py ], [3780: 4-Cl-2-ACNH-3-Py], [3781: 5-Cl-2-ACNH-3-Py], [3782: 6-Cl-2-ACNH-3-Py], [3783: 4-Me-2-ACNH-3-Py], [37 84: 5-Me-2-ACNH-3-Py], [3785: 6-Me-2-ACNH-3-Py], [3786: 4-CF3-2-ACNH-3-Py], [3787: 5-CF3-2-ACNH-3-Py], [3788: 6-CF3-2-ACNH-3-Py], [3789: 4-CN-2-ACNH-3-Py], [3790: 5- CN-2-ACNH-3-Py], [3791: 6-CN-2-ACNH-3-Py], [3792: 4-OMe-2-ACNH-3-Py], [3793: 5-OMe- 2-ACNH-3-Py], [3794: 6-OMe-2-ACNH-3-Py], [3795: 4-ACNH-3-Py], [3796: 2-Cl-4-ACNH-3- Py], [3797: 5-Cl-4-ACNH-3-Py] [3798: 6-Cl-4-ACNH-3-Py], [3799: 2-Me-4-ACNH-3-Py], [3800: 5-Me-4-ACNH-3-Py],

[3801: 6-Me-4-ACNH-3-Py], [3802: 2-CF3-4-ACNH-3-Py], [3803: 5-CF3-4-ACNH-3-Py], [3804 : 6-CF3-4-ACNH-3-Py], [3805: 2-CN-4-ACNH-3-Py], [3806: 5-CN-4-ACNH-3-Py], [3807: 6 -CN-4-ACNH-3-Py], [3808: 2-OMe-4-ACNH-3-Py], [3809: 5-OMe-4-ACNH-3-Py], [3810: 6-OMe -4-ACNH-3-Py], [3811: 5-ACNH-3-Py], [3812: 2-Cl-5-ACNH-3-Py], [3813: 4-Cl-5-ACNH-3 -Py], [3814: 6-Cl-5-ACNH-3- y], [3815: 2-Me-5-ACNH-3-Py], [3816: 4-Me-5-ACNH-3-Py], [3817: 6-Me-5-ACNH-3-Py] [3818: 2-CF3-5-ACNH-3-Py], [3819: 4-CF3-5-ACNH-3-Py], [3820: 6-CF3-5-ACNH-3-Py], [ 3821: 2-CN-5-ACNH-3-Py], [3822: 4-CN-5-ACNH-3-Py], [3823: 6-CN-5-ACNH-3-Py], [3824: 2-OMe-5-ACNH-3-Py], [3825: 4-OMe-5-ACNH-3-Py], [3826: 6-OMe-5-ACNH-3-Py], [3827: 6- ACNH-3-Py], [3828: 2-Cl-6-ACN -3-Py], [3829: 4-Cl-6-ACNH-3-Py], [3830: 5-Cl-6-ACNH-3-Py], [3831: 2-Me-6-ACNH-3 -Py], [3832: 4-Me-6-ACNH-3-Py], [3833: 5-Me-6-ACNH-3-Py], [3834: 2-CF3-6-ACNH-3-Py ], [3835: 4-CF3-6-ACNH-3-Py], [3836: 5-CF3-6-ACNH-3-Py], [3837: 2-CN-6-ACNH-3-Py], [3838: 4-CN-6-ACNH-3-Py], [3839: 5-CN-6-ACNH-3-Py], [3840: 2-OMe-6-ACNH-3-Py], [3841 : 4-OMe-6-ACNH-3-Py], [3842: 5-O Me-6-ACNH-3-Py], [3843: 2- (N-AC-N-Me-N) -3-Py], [3844: 4-Cl-2- (N-AC-N-Me). -N) -3-Py], [3845: 5-Cl-2- (N-AC-N-Me-N) -3-Py], [3846: 6-Cl-2- (N-AC-N). -Me-N) -3-Py], [3847: 4-Me-2- (N-AC-N-Me-N) -3-Py], [3848: 5-Me-2- (N-AC). -N-Me-N) -3-Py], [3849: 6-Me-2- (N-AC-N-Me-N) -3-Py], [3850: 4-CF3-2- (N -AC-N-Me-N) -3-Py], [3851: 5-CF3-2- (N-AC-N-Me-N) -3-Py], [3852: 6-CF3-2- (N-AC-N-M -N) -3-Py], [3853: 4-CN-2- (N-AC-N-Me-N) -3-Py], [3854: 5-CN-2- (N-AC-N). -Me-N) -3-Py], [3855: 6-CN-2- (N-AC-N-Me-N) -3-Py], [3856: 4-OMe-2- (N-AC) -N-Me-N) -3-Py], [3857: 5-OMe-2- (N-AC-N-Me-N) -3-Py], [3858: 6-OMe-2- (N -AC-N-Me-N) -3-Py], [3859: 4- (N-AC-N-Me-N) -3-Py], [3860: 2-Cl-4- (N-AC). -N-Me-N) -3-Py], [3861: 5-Cl-4- (N-AC-N-Me-N) -3-Py], [3862: 6-Cl-4- (N -AC-N-Me-N)- -Py], [3863: 2-Me-4- (N-AC-N-Me-N) -3-Py], [3864: 5-Me-4- (N-AC-N-Me-N). -3-Py], [3865: 6-Me-4- (N-AC-N-Me-N) -3-Py], [3866: 2-CF3-4- (N-AC-N-Me- N) -3-Py], [3867: 5-CF3-4- (N-AC-N-Me-N) -3-Py], [3868: 6-CF3-4- (N-AC-N- Me-N) -3-Py], [3869: 2-CN-4- (N-AC-N-Me-N) -3-Py], [3870: 5-CN-4- (N-AC- N-Me-N) -3-Py], [3871: 6-CN-4- (N-AC-N-Me-N) -3-Py], [3872: 2-OMe-4- (N- AC-N-Me-N)- 3-Py], [3873: 5-OMe-4- (N-AC-N-Me-N) -3-Py], [3874: 6-OMe-4- (N-AC-N-Me-N) ) -3-Py], [3875: 5- (N-AC-N-Me-N) -3-Py], [3876: 2-Cl-5- (N-AC-N-Me-N)- 3-Py], [3877: 4-Cl-5- (N-AC-N-Me-N) -3-Py], [3878: 6-Cl-5- (N-AC-N-Me-N) ) -3-Py], [3879: 2-Me-5- (N-AC-N-Me-N) -3-Py], [3880: 4-Me-5- (N-AC-N-Me). -N) -3-Py], [3881: 6-Me-5- (N-AC-N-Me-N) -3-Py], [3882: 2-CF3-5- (N-AC-N). -Me-N) -3-Py] [3883: 4-CF3-5- (N-AC-N-Me-N) -3-Py], [3884: 6-CF3-5- (N-AC-N-Me-N) -3-Py ], [3885: 2-CN-5- (N-AC-N-Me-N) -3-Py], [3886: 4-CN-5- (N-AC-N-Me-N) -3. -Py], [3887: 6-CN-5- (N-AC-N-Me-N) -3-Py], [3888: 2-OMe-5- (N-AC-N-Me-N) -3-Py], [3889: 4-OMe-5- (N-AC-N-Me-N) -3-Py], [3890: 6-OMe-5- (N-AC-N-Me- N) -3-Py], [3891: 6- (N-AC-N-Me-N) -3-Py], [3892: 2-Cl-6- (N-AC-N-Me-N) -3-Py], [3 93: 4-Cl-6- (N-AC-N-Me-N) -3-Py], [3894: 5-Cl-6- (N-AC-N-Me-N) -3-Py] [3895: 2-Me-6- (N-AC-N-Me-N) -3-Py], [3896: 4-Me-6- (N-AC-N-Me-N) -3-. Py], [3897: 5-Me-6- (N-AC-N-Me-N) -3-Py], [3898: 2-CF3-6- (N-AC-N-Me-N)- 3-Py], [3899: 4-CF3-6- (N-AC-N-Me-N) -3-Py], [3900: 5-CF3-6- (N-AC-N-Me-N) ) -3-Py],

[3901: 2-CN-6- (N-AC-N-Me-N) -3-Py], [3902: 4-CN-6- (N-AC-N-Me-N) -3-Py ], [3903: 5-CN-6- (N-AC-N-Me-N) -3-Py], [3904: 2-OMe-6- (N-AC-N-Me-N) -3. -Py], [3905: 4-OMe-6- (N-AC-N-Me-N) -3-Py], [3906: 5-OMe-6- (N-AC-N-Me-N) -3-Py] [3907: 2-AC-3-Py], [3908: 4-Cl-2-AC-3-Py], [3909: 5-Cl-2-AC-3-Py], [ 3910: 6-Cl-2-AC-3-Py], [3911: 4-Me-2-AC-3-Py], [3912: 5-Me-2-AC-3-Py], [3913: -Me-2-AC-3-Py], [3914: 4-CF3-2-AC-3-Py], [3915: 5-CF3-2-AC-3-Py], [3916: 6-CF3 -2-AC-3-Py], [3917: 4-CN-2-AC-3-Py], [3918: 5-CN-2-AC-3-Py], [3919: 6-CN-2 -AC-3-Py], [3920: 4-OMe-2-AC-3-Py], [3921: 5-OMe-2-AC-3-Py], [3922: 6-OMe-2-AC -3-Py], [3923: 4-AC-3-Py], [3924: 2-Cl-4-AC-3-Py], [3925: 5-Cl-4-AC-3-Py], [3926: 6-Cl-4-AC-3-Py], [3927: 2-Me-4-AC-3-Py], [3928: 5- e-4-AC-3-Py], [3929: 6-Me-4-AC-3-Py], [3930: 2-CF3-4-AC-3-Py], [3931: 5-CF3- 4-AC-3-Py], [3932: 6-CF3-4-AC-3-Py], [3933: 2-CN-4-AC-3-Py], [3934: 5-CN-4-. AC-3-Py], [3935: 6-CN-4-AC-3-Py], [3936: 2-OMe-4-AC-3-Py], [3937: 5-OMe-4-AC- 3-Py], [3938: 6-OMe-4-AC-3-Py], [3939: 5-AC-3-Py], [3940: 2-Cl-5-AC-3-Py], [ 3941: 4-Cl-5-AC-3-Py], [3942: 6-Cl-5-AC-3-Py], [3943: 2-Me- 5-AC-3-Py], [3944: 4-Me-5-AC-3-Py], [3945: 6-Me-5-AC-3-Py], [3946: 2-CF3-5 AC-3-Py], [3947: 4-CF3-5-AC-3-Py], [3948: 6-CF3-5-AC-3-Py], [3949: 2-CN-5-AC- 3-Py], [3950: 4-CN-5-AC-3-Py], [3951: 6-CN-5-AC-3-Py], [3952: 2-OMe-5-AC-3- Py], [3953: 4-OMe-5-AC-3-Py], [3954: 6-OMe-5-AC-3-Py], [3955: 6-AC-3-Py], [3956: 2-Cl-6-AC-3-Py], [3957: 4-Cl-6-AC-3-Py], [3958: 5-Cl-6 C-3-Py], [3959: 2-Me-6-AC-3-Py], [3960: 4-Me-6-AC-3-Py], [3961: 5-Me-6-AC- 3-Py], [3962: 2-CF3-6-AC-3-Py], [3963: 4-CF3-6-AC-3-Py], [3964: 5-CF3-6-AC-3- Py], [3965: 2-CN-6-AC-3-Py], [3966: 4-CN-6-AC-3-Py], [3967: 5-CN-6-AC-3-Py] [3968: 2-OMe-6-AC-3-Py], [3969: 4-OMe-6-AC-3-Py], [3970: 5-OMe-6-AC-3-Py], [ 3971: 4-Py], [3972: 3-F-4-Py], [3953: 2-Cl-3-F-4-Py], [3974] 5-Cl-3-F-4-Py], [3975: 6-Cl-3-F-4-Py], [3976: 2-Me-3-F-4-Py], [3777: 5- Me-3-F-4-Py], [3978: 6-Me-3-F-4-Py], [31979: 2-CF3-3-F-4-Py], [3980: 5-CF3- 3-F-4-Py], [3981: 6-CF3-3-3-F-4-Py], [3982: 2-CN-3-F-4-Py], [3983: 5-CN-3- F-4-Py], [3984: 6-CN-3-F-4-Py], [3985: 2-OMe-3-F-4-Py], [3986: 5-OMe-3-F- 4-Py], [3987: 6-OMe-3-F-4-Py], [3988: 2-F-4-Py], [3989: 3-Cl-2-F-4-Py], [ 3 990: 5-Cl-2-F-4-Py], [3991: 6-Cl-2-F-4-Py], [3992: 3-Me-2-F-4-Py], [3993: 5-Me-2-F-4-Py], [3994: 6-Me-2-F-4-Py], [3395: 3-CF3-2-F-4-Py], [3996: 5- CF3-2-F-4-Py], [3997: 6-CF3-2-F-4-Py], [3998: 3-CN-2-F-4-Py], [3999: 5-CN- 2-F-4-Py], [4000: 6-CN-2-F-4-Py],

[4001: 3-OMe-2-F-4-Py], [4002: 5-OMe-2-F-4-Py], [4003: 6-OMe-2-F-4-Py], [4004 : 5-F-4-Py], [4005: 3-Cl-5-F-4-Py], [4006: 2-Cl-5-F-4-Py], [4007: 6-Cl-5. -F-4-Py], [4008: 3-Me-5-F-4-Py], [4009: 2-Me-5-F-4-Py], [4010: 6-Me-5-F. -4-Py], [4011: 3-CF3-5-F-4-Py], [4012: 2-CF3-5-F-4-Py], [4013: 6-CF3-5-F-4] -Py], [4014: 3-CN-5-F-4-Py], [4015: 2-CN-5-F-4-Py], [4016: 6-CN-5-F-4- y], [4017: 3-OMe-5-F-4-Py], [4018: 2-OMe-5-F-4-Py], [4019: 6-OMe-5-F-4-Py] [4020: 6-F-4-Py], [4021: 3-Cl-6-F-4-Py], [4022: 2-Cl-6-F-4-Py], [4023: 5- Cl-6-F-4-Py], [4024: 3-Me-6-F-4-Py], [4025: 2-Me-6-F-4-Py], [4026: 5-Me- 6-F-4-Py], [4027: 3-CF3-6-F-4-Py], [4028: 2-CF3-6-F-4-Py], [4029: 5-CF3-6 F-4-Py], [4030: 3-CN-6-F-4-Py], [4031: 2-CN-6-F-4-Py], [4032: 5-CN-6 -4-Py], [4033: 3-OMe-6-F-4-Py], [4034: 2-OMe-6-F-4-Py], [4035: 5-OMe-6-F-4 -Py], [4036: 3-Cl-4-Py], [4037: 2-Cl-3-Cl-4-Py], [4038: 5-Cl-3-Cl-4-Py], [4039 : 6-Cl-3-Cl-4-Py], [4040: 2-Me-3-Cl-4-Py], [4041: 5-Me-3-Cl-4-Py], [4042: 6 -Me-3-Cl-4-Py], [4043: 2-CF3-3-Cl-4-Py], [4044: 5-CF3-3-Cl-4-Py], [4045: 6-CF3 -3-Cl-4-Py], [4046: 2-CN-3-Cl-4-Py], [4047: 5-CN-3-Cl-4-Py] ], [4048: 6-CN-3-Cl-4-Py], [4049: 2-OMe-3-Cl-4-Py], [4050: 5-OMe-3-Cl-4-Py], [4051: 6-OMe-3-Cl-4-Py], [4052: 2-Cl-4-Py], [4053: 3-Cl-2-Cl-4-Py], [4054: 5-Cl -2-Cl-4-Py], [4055: 6-Cl-2-Cl-4-Py], [4056: 3-Me-2-Cl-4-Py], [4057: 5-Me-2 -Cl-4-Py], [4058: 6-Me-2-Cl-4-Py], [4059: 3-CF3-2-Cl-4-Py], [4060: 5-CF3-2-Cl] -4-Py], [4061: 6-CF3-2-Cl-4-Py], [4062: 3-CN-2-Cl-4-Py], 4063: 5-CN-2-Cl-4-Py], [4064: 6-CN-2-Cl-4-Py], [4065: 3-OMe-2-Cl-4-Py], [4066: 5-OMe-2-Cl-4-Py], [4067: 6-OMe-2-Cl-4-Py], [4068: 5-Cl-4-Py], [4069: 2-Cl-5 Cl-4-Py], [4070: 5-Cl-5-Cl-4-Py], [4071: 6-Cl-5-Cl-4-Py], [4072: 2-Me-5-Cl- 4-Py], [4073: 5-Me-5-Cl-4-Py], [4074: 6-Me-5-Cl-4-Py], [4075: 2-CF3-5-Cl-4- Py], [4076: 5-CF3-5-Cl-4-Py], [4077: 6-CF3-5-Cl-4-Py], [4 78: 2-CN-5-Cl-4-Py], [4079: 3-CN-5-Cl-4-Py], [4080: 6-CN-5-Cl-4-Py], [4081: 2-OMe-5-Cl-4-Py], [4082: 5-OMe-5-Cl-4-Py], [4083: 6-OMe-5-Cl-4-Py], [4084: 6- Cl-4-Py], [4085: 3-Cl-6-Cl-4-Py], [4086: 2-Cl-6-Cl-4-Py], [4087: 5-Cl-6-Cl- 4-Py], [4088: 3-Me-6-Cl-4-Py], [4089: 2-Me-6-Cl-4-Py], [4090: 5-Me-6-Cl-4- Py], [4091: 3-CF3-6-Cl-4-Py], [4092: 2-CF3-6-Cl-4-Py], [4093: 5-CF3-6-Cl-4-Py], [4094: 3-CN-6-Cl-4-Py], [4095: 2-CN-6-Cl-4-Py], [4096: 5- CN-6-Cl-4-Py], [4097: 3-OMe-6-Cl-4-Py], [4098: 2-OMe-6-Cl-4-Py], [4099: 5-OMe- 6-Cl-4-Py], [4100: 3-Br-4-Py],

[4101: 2-Cl-3-Br-4-Py], [4102: 5-Cl-3-Br-4-Py], [4103: 6-Cl-3-Br-4-Py], [4104 : 2-Me-3-Br-4-Py], [4105: 5-Me-3-Br-4-Py], [4106: 6-Me-3-Br-4-Py], [4107: 2 -CF3-3-Br-4-Py], [4108: 5-CF3-3-Br-4-Py], [4109: 6-CF3-3-Br-4-Py], [4110: 2-CN -3-Br-4-Py], [4111: 5-CN-3-Br-4-Py], [4112: 6-CN-3-Br-4-Py], [4113: 2-OMe-3 -Br-4-Py], [4114: 5-OMe-3-Br-4-Py], [4115: 6-OMe-3-Br-4-P ], [4116: 2-Br-4-Py], [4117: 3-Cl-2-Br-4-Py], [4118: 5-Cl-2-Br-4-Py], [4119: 6 -Cl-2-Br-4-Py], [4120: 3-Me-2-Br-4-Py], [4121: 5-Me-2-Br-4-Py], [4122: 6-Me -2-Br-4-Py], [4123: 3-CF3-2-Br-4-Py], [4124: 5-CF3-2-Br-4-Py], [4125: 6-CF3-2 -Br-4-Py], [4126: 3-CN-2-Br-4-Py], [4127: 5-CN-2-Br-4-Py], [4128: 6-CN-2-Br -4-Py], [4129: 3-OMe-2-Br-4-Py], [4130: 5-OMe-2-Br-4-Py], 4131: 6-OMe-2-Br-4-Py], [4132: 5-Br-4-Py], [4133: 3-Cl-5-Br-4-Py], [4134: 2-Cl- 5-Br-4-Py], [4135: 6-Cl-5-Br-4-Py], [4136: 3-Me-5-Br-4-Py], [4137: 2-Me-5- Br-4-Py], [4138: 6-Me-5-Br-4-Py], [4139: 3-CF3-5-Br-4-Py], [4140: 2-CF3-5-Br- 4-Py], [4141: 6-CF3-5-Br-4-Py], [4142: 3-CN-5-Br-4-Py], [4143: 2-CN-5-Br-4- Py], [4144: 6-CN-5-Br-4-Py], [4145: 3-OMe-5-Br-4-Py], [414 6: 2-OMe-5-Br-4-Py], [4147: 6-OMe-5-Br-4-Py], [4148: 6-Br-4-Py], [4149: 3-Cl- 6-Br-4-Py], [4150: 2-Cl-6-Br-4-Py], [4151: 5-Cl-6-Br-4-Py], [4152: 3-Me-6- Br-4-Py], [4153: 2-Me-6-Br-4-Py], [4154: 5-Me-6-Br-4-Py], [4155: 3-CF3-6-Br- 4-Py], [4156: 2-CF3-6-Br-4-Py], [4157: 5-CF3-6-Br-4-Py], [4158: 3-CN-6-Br-4- Py], [4159: 2-CN-6-Br-4-Py], [4160: 5-CN-6-Br-4-Py], [4161: 3 OMe-6-Br-4-Py], [4162: 2-OMe-6-Br-4-Py], [4163: 5-OMe-6-Br-4-Py], [4164: 3-I- 4-Py], [4165: 2-Cl-3-I-4-Py], [4166: 5-Cl-3-I-4-Py], [4167: 6-Cl-3-I-4- Py], [4168: 2-Me-3-I-4-Py], [4169: 5-Me-3-I-4-Py], [4170: 6-Me-3-I-4-Py] [4171: 2-CF3-3-1-I-4-Py], [4172: 5-CF3-3-3-I-4-Py], [4173: 6-CF3-3-3-I-4-Py], [ 4174: 2-CN-3-I-4-Py], [4175: 5-CN-3-I-4-Py], [4176: 6-CN-3-I-4-Py], 4177: 2-OMe-3-I-4-Py], [4178: 5-OMe-3-I-4-Py], [4179: 6-OMe-3-I-4-Py], [4180: 2-I-4-Py], [4181: 3-Cl-2-I-4-Py], [4182: 5-Cl-2-I-4-Py], [4183: 6-Cl-2- I-4-Py], [4184: 3-Me-2-I-4-Py], [4185: 5-Me-2-I-4-Py], [4186: 6-Me-2-I- 4-Py], [4187: 3-CF3-2-I-4-Py], [4188: 5-CF3-2-I-4-Py], [4189: 6-CF3-2-I-4- Py], [4190: 3-CN-2-I-4-Py], [4191: 5-CN-2-I-4-Py], [4192: 6-CN-2-I-4-P y], [4193: 3-OMe-2-I-4-Py], [4194: 5-OMe-2-I-4-Py], [4195: 6-OMe-2-I-4-Py] [4196: 5-I-4-Py], [4197: 3-Cl-5-I-4-Py], [4198: 2-Cl-5-I-4-Py], [4199: 6- Cl-5-I-4-Py], [4200: 3-Me-5-I-4-Py],

[4201: 2-Me-5-I-4-Py], [4202: 6-Me-5-I-4-Py], [4203: 3-CF3-5-I-4-Py], [4204] : 2-CF3-5-I-4-Py], [4205: 6-CF3-5-I-4-Py], [4206: 3-CN-5-I-4-Py], [4207: 2 -CN-5-I-4-Py], [4208: 6-CN-5-I-4-Py], [4209: 3-OMe-5-I-4-Py], [4210: 2-OMe -5-I-4-Py], [4211: 6-OMe-5-I-4-Py], [4212: 6-I-4-Py], [4213: 3-Cl-6-I-4 -Py], [4214: 2-Cl-6-I-4-Py], [4215: 5-Cl-6-I-4-Py], [4216: 3-Me-6-I-4- y], [4217: 2-Me-6-I-4-Py], [4218: 5-Me-6-I-4-Py], [4219: 3-CF3-6-I-4-Py] [4220: 2-CF3-6-I-4-Py], [4221: 5-CF3-6-I-4-Py], [4222: 3-CN-6-I-4-Py], [ 4223: 2-CN-6-I-4-Py], [4224: 5-CN-6-I-4-Py], [4225: 3-OMe-6-I-4-Py], [4226: 2-OMe-6-I-4-Py], [4227: 5-OMe-6-I-4-Py], [4228: 3-Me-4-Py], [4229: 2-Cl-3- Me-4-Py], [4230: 5-Cl-3-Me-4-Py], [4231: 6-Cl-3-Me-4-Py], [4232: 2-M -3-Me-4-Py], [4233: 5-Me-3-Me-4-Py], [4234: 6-Me-3-Me-4-Py], [4235: 2-CF3-3. -Me-4-Py], [4236: 5-CF3-3-Me-4-Py], [4237: 6-CF3-3-Me-4-Py], [4238: 2-CN-3-Me. -4-Py], [4239: 5-CN-3-Me-4-Py], [4240: 6-CN-3-Me-4-Py], [4241: 2-OMe-3-Me-4 -Py], [4242: 5-OMe-3-Me-4-Py], [4243: 6-OMe-3-Me-4-Py], [4244: 2-Me-4-Py], [4245. : 3-Cl-2-Me-4-Py], [4246: 5-Cl-2-Me-4-Py], [4247: 6-Cl-2 -Me-4-Py], [4248: 3-Me-2-Me-4-Py], [4249: 5-Me-2-Me-4-Py], [4250: 6-Me-2-Me -4-Py], [4251: 3-CF3-2-Me-4-Py], [4252: 5-CF3-2-Me-4-Py], [4253: 6-CF3-2-Me-4. -Py], [4254: 3-CN-2-Me-4-Py], [4255: 5-CN-2-Me-4-Py], [4256: 6-CN-2-Me-4-Py ], [4257: 3-OMe-2-Me-4-Py], [4258: 5-OMe-2-Me-4-Py], [4259: 6-OMe-2-Me-4-Py], [4260: 5-Me-4-Py], [4261: 3-Cl-5-Me-4-Py], [4262: 2-Cl-5-M -4-Py], [4263: 6-Cl-5-Me-4-Py], [4264: 3-Me-5-Me-4-Py], [4265: 2-Me-5-Me-4. -Py], [4266: 6-Me-5-Me-4-Py], [4267: 3-CF3-5-Me-4-Py], [4268: 2-CF3-5-Me-4-Py]. ], [4269: 6-CF3-5-Me-4-Py], [4270: 3-CN-5-Me-4-Py], [4271: 2-CN-5-Me-4-Py], [4272: 6-CN-5-Me-4-Py], [4273: 3-OMe-5-Me-4-Py], [4274: 2-OMe-5-Me-4-Py], [4275 : 6-OMe-5-Me-4-Py], [4276: 6-Me-4-Py], [4277: 3-Cl-6-Me- -Py], [4278: 2-Cl-6-Me-4-Py], [4279: 5-Cl-6-Me-4-Py], [4280: 3-Me-6-Me-4-Py ], [4281: 2-Me-6-Me-4-Py], [4282: 5-Me-6-Me-4-Py], [4283: 3-CF3-6-Me-4-Py], [4284: 2-CF3-6-Me-4-Py], [4285: 5-CF3-6-Me-4-Py], [4286: 3-CN-6-Me-4-Py], [4287 : 2-CN-6-Me-4-Py], [4288: 5-CN-6-Me-4-Py], [4289: 3-OMe-6-Me-4-Py], [4290: 2 -OMe-6-Me-4-Py], [4291: 5-OMe-6-Me-4-Py], [4292: 3-OMe-4- Py], [4293: 2-Cl-3-OMe-4-Py], [4294: 5-Cl-3-OMe-4-Py], [4295: 6-Cl-3-OMe-4-Py] [4296: 2-Me-3-OMe-4-Py], [4297: 5-Me-3-OMe-4-Py], [4298: 6-Me-3-OMe-4-Py], [ 4299: 2-CF3-3-OMe-4-Py], [4300: 5-CF3-3-OMe-4-Py],

[4301: 6-CF3-3-OMe-4-Py], [4302: 2-CN-3-OMe-4-Py], [4303: 5-CN-3-OMe-4-Py], [4304 : 6-CN-3-OMe-4-Py], [4305: 2-OMe-3-OMe-4-Py], [4306: 5-OMe-3-OMe-4-Py], [4307: 6 -OMe-3-OMe-4-Py], [4308: 2-OMe-4-Py], [4309: 3-Cl-2-OMe-4-Py], [4310: 5-Cl-2-OMe -4-Py], [4311: 6-Cl-2-OMe-4-Py], [4312: 3-Me-2-OMe-4-Py], [4313: 5-Me-2-OMe-4 -Py], [4314: 6-Me-2-OMe-4-Py], [4315: 3-CF3- -OMe-4-Py], [4316: 5-CF3-2-OMe-4-Py], [4317: 6-CF3-2-OMe-4-Py], [4318: 3-CN-2-OMe -4-Py], [4319: 5-CN-2-OMe-4-Py], [4320: 6-CN-2-OMe-4-Py], [4321: 3-OMe-2-OMe-4 -Py], [4322: 5-OMe-2-OMe-4-Py], [4323: 6-OMe-2-OMe-4-Py], [4324: 5-OMe-4-Py], [4325. : 3-Cl-5-OMe-4-Py], [4326: 2-Cl-5-OMe-4-Py], [4327: 6-Cl-5-OMe-4-Py], [4328: 3 -Me-5-OMe-4-Py], [4329: 2-Me-5-OMe-4-Py] [4330: 6-Me-5-OMe-4-Py], [4331: 3-CF3-5-OMe-4-Py], [4332: 2-CF3-5-OMe-4-Py], [4333 : 6-CF3-5-OMe-4-Py], [4334: 3-CN-5-OMe-4-Py], [4335: 2-CN-5-OMe-4-Py], [4336: 6 -CN-5-OMe-4-Py], [4337: 3-OMe-5-OMe-4-Py], [4338: 2-OMe-5-OMe-4-Py], [4339: 6-OMe -5-OMe-4-Py], [4340: 6-OMe-4-Py], [4341: 3-Cl-6-OMe-4-Py], [4342: 2-Cl-6-OMe-4 -Py], [4343: 5-Cl-6-OMe-4-Py], [4344: 3-Me -6-OMe-4-Py], [4345: 2-Me-6-OMe-4-Py], [4346: 5-Me-6-OMe-4-Py], [4347: 3-CF3-6 -OMe-4-Py], [4348: 2-CF3-6-OMe-4-Py], [4349: 5-CF3-6-OMe-4-Py], [4350: 3-CN-6-OMe -4-Py], [4351: 2-CN-6-OMe-4-Py], [4352: 5-CN-6-OMe-4-Py], [4353: 3-OMe-6-OMe-4 -Py], [4354: 2-OMe-6-OMe-4-Py], [4355: 5-OMe-6-OMe-4-Py], [4356: 3-CF3-4-Py], [4357 : 2-Cl-3-CF3-4-Py], [4358: 5-Cl-3-CF3-4-P ], [4359: 6-Cl-3-CF3-4-Py], [4360: 2-Me-3-CF3-4-Py], [4361: 5-Me-3-CF3-4-Py], [4362: 6-Me-3-CF3-4-Py], [4363: 2-CF3-3-CF3-4-Py], [4364: 5-CF3-3-CF3-4-Py], [4365 : 6-CF3-3-CF3-4-Py], [4366: 2-CN-3-CF3-4-Py], [4367: 5-CN-3-CF3-4-Py], [4368: 6 -CN-3-CF3-4-Py], [4369: 2-OMe-3-CF3-4-Py], [4370: 5-OMe-3-CF3-4-Py], [4371: 6-OMe -3-CF3-4-Py], [4372: 2-CF3-4-Py], [4373: 3 Cl-2-CF3-4-Py], [4374: 5-Cl-2-CF3-4-Py], [4375: 6-Cl-2-CF3-4-Py], [4376: 3-Me- 2-CF3-4-Py], [4377: 5-Me-2-CF3-4-Py], [4378: 6-Me-2-CF3-4-Py], [4379: 3-CF3-2- CF3-4-Py], [4380: 5-CF3-2-CF3-4-Py], [4381: 6-CF3-2-CF3-4-Py], [4382: 3-CN-2-CF3- 4-Py], [4383: 5-CN-2-CF3-4-Py], [4384: 6-CN-2-CF3-4-Py], [4385: 3-OMe-2-CF3-4- Py], [4386: 5-OMe-2-CF3-4-Py], [4387: 6-OMe-2- CF3-4-Py], [4388: 5-CF3-4-Py], [4389: 3-Cl-5-CF3-4-Py], [4390: 2-Cl-5-CF3-4-Py] [4391: 6-Cl-5-CF3-4-Py], [4392: 3-Me-5-CF3-4-Py], [4393: 2-Me-5-CF3-4-Py], [ 4394: 6-Me-5-CF3-4-Py], [4395: 3-CF3-5-CF3-4-Py], [4396: 2-CF3-5-CF3-4-Py], [4397: 6-CF3-5-CF3-4-Py], [4398: 3-CN-5-CF3-4-Py], [4399: 2-CN-5-CF3-4-Py], [4400: 6- CN-5-CF3-4-Py],

[4401: 3-OMe-5-CF3-4-Py], [4402: 2-OMe-5-CF3-4-Py], [4403: 6-OMe-5-CF3-4-Py], [4404 : 6-CF3-4-Py], [4405: 3-Cl-6-CF3-4-Py], [4406: 2-Cl-6-CF3-4-Py], [4407: 5-Cl-6 -CF3-4-Py], [4408: 3-Me-6-CF3-4-Py], [4409: 2-Me-6-CF3-4-Py], [4410: 5-Me-6-CF3 -4-Py], [4411: 3-CF3-6-CF3-4-Py], [4412: 2-CF3-6-CF3-4-Py], [4413: 5-CF3-6-CF3-4. -Py], [4414: 3-CN-6-CF3-4-Py], [4415: 2-CN 6-CF3-4-Py], [4416: 5-CN-6-CF3-4-Py], [4417: 3-OMe-6-CF3-4-Py], [4418: 2-OMe-6 CF3-4-Py], [4419: 5-OMe-6-CF3-4-Py], [4420: 3-OCF3-4-Py], [4421: 2-Cl-3-OCF3-4-Py] [4422: 5-Cl-3-OCF3-4-Py], [4423: 6-Cl-3-OCF3-4-Py], [4424: 2-Me-3-OCF3-4-Py], [ 4425: 5-Me-3-OCF3-4-Py], [4426: 6-Me-3-OCF3-4-Py], [4427: 2-CF3-3-OCF3-4-Py], [4428: 5-CF3-3-OCF3-4-Py], [4429: 6-CF3- -OCF3-4-Py], [4430: 2-CN-3-OCF3-4-Py], [4431: 5-CN-3-OCF3-4-Py], [4432: 6-CN-3-OCF3 -4-Py], [4433: 2-OMe-3-OCF3-4-Py], [4434: 5-OMe-3-OCF3-4-Py], [4435: 6-OMe-3-OCF3-4. -Py], [4436: 2-OCF3-4-Py], [4437: 3-Cl-2-OCF3-4-Py], [4438: 5-Cl-2-OCF3-4-Py], [4439] : 6-Cl-2-OCF3-4-Py], [4440: 3-Me-2-OCF3-4-Py], [4441: 5-Me-2-OCF3-4-Py], [4442: 6 -Me-2-OCF3-4-Py], [4443: 3-CF3 -2-OCF3-4-Py], [4444: 5-CF3-2-OCF3-4-Py], [4445: 6-CF3-2-OCF3-4-Py], [4446: 3-CN-2 -OCF3-4-Py], [4447: 5-CN-2-OCF3-4-Py], [4448: 6-CN-2-OCF3-4-Py], [4449: 3-OMe-2-OCF3 -4-Py], [4450: 5-OMe-2-OCF3-4-Py], [4451: 6-OMe-2-OCF3-4-Py], [4452: 5-OCF3-4-Py], [4453: 3-Cl-5-OCF3-4-Py], [4454: 2-Cl-5-OCF3-4-Py], [4455: 6-Cl-5-OCF3-4-Py], [4456 : 3-Me-5-OCF3-4-Py], [4457: 2 Me-5-OCF3-4-Py], [4458: 6-Me-5-OCF3-4-Py], [459: 3-CF3-5-OCF3-4-Py], [4460: 2-CF3- 5-OCF3-4-Py], [4461: 6-CF3-5-OCF3-4-Py], [4462: 3-CN-5-OCF3-4-Py], [4463: 2-CN-5 OCF3-4-Py], [4464: 6-CN-5-OCF3-4-Py], [4465: 3-OMe-5-OCF3-4-Py], [4466: 2-OMe-5-OCF3- 4-Py], [4467: 6-OMe-5-OCF3-4-Py], [4468: 6-OCF3-4-Py], [4469: 3-Cl-6-OCF3-4-Py], [ 4470: 2-Cl-6-OCF3-4-Py], [44 1: 5-Cl-6-OCF3-4-Py], [4472: 3-Me-6-OCF3-4-Py], [4473: 2-Me-6-OCF3-4-Py], [4474: 5-Me-6-OCF3-4-Py], [4475: 3-CF3-6-OCF3-4-Py], [4476: 2-CF3-6-OCF3-4-Py], [4477: 5- CF3-6-OCF3-4-Py], [4478: 3-CN-6-OCF3-4-Py], [4479: 2-CN-6-OCF3-4-Py], [4480: 5-CN- 6-OCF3-4-Py], [4481: 3-OMe-6-OCF3-4-Py], [4482: 2-OMe-6-OCF3-4-Py], [4483: 5-OMe-6 OCF3-4-Py], [4484: 3-CHF2-4-Py], [4485: 2-Cl-3-CHF2-4-Py], [4486: 5-Cl-3-CHF2-4-Py], [4487: 6-Cl-3-CHF2-4-Py], [4488 : 2-Me-3-CHF2-4-Py], [4489: 5-Me-3-CHF2-4-Py], [4490: 6-Me-3-CHF2-4-Py], [4491: 2 -CF3-3-CHF2-4-Py], [4492: 5-CF3-3-CHF2-4-Py], [4493: 6-CF3-3-CHF2-4-Py], [4494: 2-CN -3-CHF2-4-Py], [4495: 5-CN-3-CHF2-4-Py], [496: 6-CN-3-CHF2-4-Py], [4497: 2-OMe-3 -CHF2-4-Py], [4498: 5-OMe-3-CHF -4-Py], [4499: 6-OMe-3-CHF2-4-Py], [4500: 4-CHF2-4-Py],

[4501: 3-Cl-4-CHF2-4-Py], [4502: 5-Cl-4-CHF2-4-Py], [4503: 6-Cl-4-CHF2-4-Py], [4504 : 3-Me-4-CHF2-4-Py], [4505: 5-Me-4-CHF2-4-Py], [4506: 6-Me-4-CHF2-4-Py], [4507: 3 -CF3-4-CHF2-4-Py], [4508: 5-CF3-4-CHF2-4-Py], [4509: 6-CF3-4-CHF2-4-Py], [4510: 3-CN -4-CHF2-4-Py], [4511: 5-CN-4-CHF2-4-Py], [4512: 6-CN-4-CHF2-4-Py], [4513: 3-OMe-4 -CHF2-4-Py], [4514: 5-OMe-4-CHF -4-Py], [4515: 6-OMe-4-CHF2-4-Py], [4516: 5-CHF2-4-Py], [4517: 3-Cl-5-CHF2-4-Py], [4518: 2-Cl-5-CHF2-4-Py], [4519: 6-Cl-5-CHF2-4-Py], [4520: 3-Me-5-CHF2-4-Py], [4521 : 2-Me-5-CHF2-4-Py], [4522: 6-Me-5-CHF2-4-Py], [4523: 3-CF3-5-CHF2-4-Py], [4524: 2 -CF3-5-CHF2-4-Py], [4525: 6-CF3-5-CHF2-4-Py], [4526: 3-CN-5-CHF2-4-Py], [4527: 2-CN -5-CHF2-4-Py], [4528: 6-CN-5-C F2-4-Py], [4529: 3-OMe-5-CHF2-4-Py], [4530: 2-OMe-5-CHF2-4-Py], [4531: 6-OMe-5-CHF2- 4-Py], [4532: 6-CHF2-4-Py], [4533: 3-Cl-6-CHF2-4-Py], [4534: 2-Cl-6-CHF2-4-Py], [ 4535: 5-Cl-6-CHF2-4-Py], [4536: 3-Me-6-CHF2-4-Py], [4537: 2-Me-6-CHF2-4-Py], [4538: 5-Me-6-CHF2-4-Py], [4539: 3-CF3-6-CHF2-4-Py], [4540: 2-CF3-6-CHF2-4-Py], [4541: 5- CF3-6-CHF2-4-Py], [4542: 3-CN- 6-CHF2-4-Py], [4543: 2-CN-6-CHF2-4-Py], [4544: 5-CN-6-CHF2-4-Py], [4545: 3-OMe-6 CHF2-4-Py], [4546: 2-OMe-6-CHF2-4-Py], [4547: 5-OMe-6-CHF2-4-Py], [4548: 3-OCHF2-4-Py] [4549: 2-Cl-3-OCHF2-4-Py], [4550: 5-Cl-3-OCHF2-4-Py], [4551: 6-Cl-3-OCHF2-4-Py], [ 4552: 2-Me-3-OCHF2-4-Py], [4553: 5-Me-3-OCHF2-4-Py], [4554: 6-Me-3-OCHF2-4-Py], [4555: 2-CF3-3-OCHF2-4-Py], [ 556: 5-CF3-3-OCHF2-4-Py], [4557: 6-CF3-3-OCHF2-4-Py], [4558: 2-CN-3-OCHF2-4-Py], [4559: 5-CN-3-OCHF2-4-Py], [4560: 6-CN-3-OCHF2-4-Py], [4561: 2-OMe-3-OCHF2-4-Py], [4562: 5- OMe-3-OCHF2-4-Py], [4563: 6-OMe-3-OCHF2-4-Py], [4564: 4-OCHF2-4-Py], [4565: 3-Cl-4-OCHF2- 4-Py], [4566: 5-Cl-4-OCHF2-4-Py], [4567: 6-Cl-4-OCHF2-4-Py], [4568: 3-Me-4-OCHF2-4- Py], [4569: 5-M -4-OCHF2-4-Py], [4570: 6-Me-4-OCHF2-4-Py], [4571: 3-CF3-4-OCHF2-4-Py], [4572: 5-CF3-4 -OCHF2-4-Py], [4573: 6-CF3-4-OCHF2-4-Py], [4574: 3-CN-4-OCHF2-4-Py], [4575: 5-CN-4-OCHF2 -4-Py], [4576: 6-CN-4-OCHF2-4-Py], [4577: 3-OMe-4-OCHF2-4-Py], [4578: 5-OMe-4-OCHF2-4 -Py], [4579: 6-OMe-4-OCHF2-4-Py], [4580: 5-OCHF2-4-Py], [4581: 3-Cl-5-OCHF2-4-Py], [4582 : 2-Cl-5-OCHF 2-4-Py], [4583: 6-Cl-5-OCHF2-4-Py], [4584: 3-Me-5-OCHF2-4-Py], [4585: 2-Me-5-OCHF2- 4-Py], [4586: 6-Me-5-OCHF2-4-Py], [4587: 3-CF3-5-OCHF2-4-Py], [4588: 2-CF3-5-OCHF2-4- Py], [4589: 6-CF3-5-OCHF2-4-Py], [4590: 3-CN-5-OCHF2-4-Py], [4591: 2-CN-5-OCHF2-4-Py] [4592: 6-CN-5-OCHF2-4-Py], [4593: 3-OMe-5-OCHF2-4-Py], [4594: 2-OMe-5-OCHF2-4-Py], [ 4595: 6-OMe-5-OCHF2- -Py], [4596: 6-OCHF2-4-Py], [4597: 3-Cl-6-OCHF2-4-Py], [4598: 2-Cl-6-OCHF2-4-Py], [4599] : 5-Cl-6-OCHF2-4-Py], [4600: 3-Me-6-OCHF2-4-Py],

[4601: 2-Me-6-OCHF2-4-Py], [4602: 5-Me-6-OCHF2-4-Py], [4603: 3-CF3-6-OCHF2-4-Py], [4604 : 2-CF3-6-OCHF2-4-Py], [4605: 5-CF3-6-OCHF2-4-Py], [4606: 3-CN-6-OCHF2-4-Py], [4607: 2] -CN-6-OCHF2-4-Py], [4608: 5-CN-6-OCHF2-4-Py], [4609: 3-OMe-6-OCHF2-4-Py], [4610: 2-OMe -6-OCHF2-4-Py], [4611: 5-OMe-6-OCHF2-4-Py], [4612: 3-Et-4-Py], [4613: 2-Cl-3-Et-4 -Py], [4614: 5-Cl-3- t-4-Py], [4615: 6-Cl-3-Et-4-Py], [4616: 2-Me-3-Et-4-Py], [4617: 5-Me-3-Et- 4-Py], [4618: 6-Me-3-Et-4-Py], [4619: 2-CF3-3-Et-4-Py], [4620: 5-CF3-3-Et-4- Py], [4621: 6-CF3-3-3-Et-4-Py], [4622: 2-CN-3-Et-4-Py], [4623: 5-CN-3-Et-4-Py] [4624: 6-CN-3-Et-4-Py], [4625: 2-OMe-3-Et-4-Py], [4626: 5-OMe-3-Et-4-Py], [ 4627: 6-OMe-3-Et-4-Py], [4628: 2-Et-4-Py], [4629: 3-Cl-2-Et 4-Py], [4630: 5-Cl-2-Et-4-Py], [4631: 6-Cl-2-Et-4-Py], [4632: 3-Me-2-Et-4- Py], [4633: 5-Me-2-Et-4-Py], [4634: 6-Me-2-Et-4-Py], [4635: 3-CF3-2-Et-4-Py] [4636: 5-CF3-2-Et-4-Py], [4637: 6-CF3-2-Et-4-Py], [4638: 3-CN-2-Et-4-Py], [ 4639: 5-CN-2-Et-4-Py], [4640: 6-CN-2-Et-4-Py], [4641: 3-OMe-2-Et-4-Py], [4642: 5-OMe-2-Et-4-Py], [4643: 6-OMe-2-Et-4-Py], [4644: 5-Et-4- Py], [4645: 3-Cl-5-Et-4-Py], [4646: 2-Cl-5-Et-4-Py], [4647: 6-Cl-5-Et-4-Py] [4648: 3-Me-5-Et-4-Py], [4649: 2-Me-5-Et-4-Py], [4650: 6-Me-5-Et-4-Py], [ 4651: 3-CF3-5-Et-4-Py], [4652: 2-CF3-5-Et-4-Py], [4653: 6-CF3-5-Et-4-Py], [4654: 3-CN-5-Et-4-Py], [4655: 2-CN-5-Et-4-Py], [4656: 6-CN-5-Et-4-Py], [4657: 3- OMe-5-Et-4-Py], [4658: 2-OMe-5-Et-4-Py], [4659: 6-OMe-5-Et 4-Py], [4660: 6-Et-4-Py], [4661: 3-Cl-6-Et-4-Py], [4662: 2-Cl-6-Et-4-Py], [ 4663: 5-Cl-6-Et-4-Py], [4664: 3-Me-6-Et-4-Py], [4665: 2-Me-6-Et-4-Py], [4666: 5-Me-6-Et-4-Py], [4667: 3-CF3-6-Et-4-Py], [4668: 2-CF3-6-Et-4-Py], [4669: 5- CF3-6-Et-4-Py], [4670: 3-CN-6-Et-4-Py], [4671: 2-CN-6-Et-4-Py], [4672: 5-CN- 6-Et-4-Py], [4673: 3-OMe-6-Et-4-Py], [4674: 2-OMe-6-Et-4- y], [4675: 5-OMe-6-Et-4-Py], [4676: 3-CH2CF3-4-Py], [4777: 2-Cl-3-CH2CF3-4-Py], [4678: 5-Cl-3-CH2CF3-4-Py], [4679: 6-Cl-3-CH2CF3-4-Py], [4680: 2-Me-3-CH2CF3-4-Py], [4681: 5- Me-3-CH2CF3-4-Py], [4682: 6-Me-3-CH2CF3-4-Py], [4683: 2-CF3-3-CH2CF3-4-Py], [4684: 5-CF3- 3-CH2CF3-4-Py], [4865: 6-CF3-3-CH2CF3-4-Py], [4686: 2-CN-3-CH2CF3-4-Py], [4687: 5-CN-3- CH2CF3-4-P y], [4688: 6-CN-3-CH2CF3-4-Py], [4629: 2-OMe-3-CH2CF3-4-Py], [4690: 5-OMe-3-CH2CF3-4-Py] [4691: 6-OMe-3-CH2CF3-4-Py], [4692: 2-CH2CF3-4-Py], [4693: 3-Cl-2-CH2CF3-4-Py], [4694: 5- Cl-2-CH2CF3-4-Py], [4695: 6-Cl-2-CH2CF3-4-Py], [4696: 3-Me-2-CH2CF3-4-Py], [4697: 5-Me- 2-CH2CF3-4-Py], [4698: 6-Me-2-CH2CF3-4-Py], [4699: 3-CF3-2-CH2CF3-4-Py], [4700: 5-CF3-2- CH2CF -4-Py],

[4701: 6-CF3-2-CH2CF3-4-Py], [4702: 3-CN-2-CH2CF3-4-Py], [4703: 5-CN-2-CH2CF3-4-Py], [4704 : 6-CN-2-CH2CF3-4-Py], [4705: 3-OMe-2-CH2CF3-4-Py], [4706: 5-OMe-2-CH2CF3-4-Py], [4707: 6 -OMe-2-CH2CF3-4-Py], [4708: 5-CH2CF3-4-Py], [4709: 3-Cl-5-CH2CF3-4-Py], [4710: 2-Cl-5-CH2CF3 -4-Py], [4711: 6-Cl-5-CH2CF3-4-Py], [4712: 3-Me-5-CH2CF3-4-Py], [4713: 2-Me-5-CH2CF3-4. − y], [4714: 6-Me-5-CH2CF3-4-Py], [4715: 3-CF3-5-CH2CF3-4-Py], [4716: 2-CF3-5-CH2CF3-4-Py] [4717: 6-CF3-5-CH2CF3-4-Py], [4718: 3-CN-5-CH2CF3-4-Py], [4719: 2-CN-5-CH2CF3-4-Py], [ 4720: 6-CN-5-CH2CF3-4-Py], [4721: 3-OMe-5-CH2CF3-4-Py], [4722: 2-OMe-5-CH2CF3-4-Py], [4723: 6-OMe-5-CH2CF3-4-Py], [4724: 6-CH2CF3-4-Py], [4725: 3-Cl-6-CH2CF3-4-Py], [4726: 2-Cl-6 CH2 F3-4-Py], [4727: 5-Cl-6-CH2CF3-4-Py], [4728: 3-Me-6-CH2CF3-4-Py], [4729: 2-Me-6-CH2CF3- 4-Py], [4730: 5-Me-6-CH2CF3-4-Py], [4731: 3-CF3-6-CH2CF3-4-Py], [4732: 2-CF3-6-CH2CF3-4- Py], [4733: 5-CF3-6-CH2CF3-4-Py], [4734: 3-CN-6-CH2CF3-4-Py], [4735: 2-CN-6-CH2CF3-4-Py] [4736: 5-CN-6-CH2CF3-4-Py], [4737: 3-OMe-6-CH2CF3-4-Py], [4738: 2-OMe-6-CH2CF3-4-Py], [ 4739: 5 -OMe-6-CH2CF3-4-Py], [4740: 3-OEt-4-Py], [4741: 2-Cl-3-OEt-4-Py], [4742: 5-Cl-3-OEt -4-Py], [4743: 6-Cl-3-OEt-4-Py], [4744: 2-Me-3-OEt-4-Py], [4745: 5-Me-3-OEt-4. -Py], [4746: 6-Me-3-OEt-4-Py], [4747: 2-CF3-3-OEt-4-Py], [4748: 5-CF3-3-OEt-4-Py]. ], [4749: 6-CF3-3-OEt-4-Py], [4750: 2-CN-3-OEt-4-Py], [4751: 5-CN-3-OEt-4-Py], [4752: 6-CN-3-OEt-4-Py], [4753: 2-OMe-3-OE -4-Py], [4754: 5-OMe-3-OEt-4-Py], [4755: 6-OMe-3-OEt-4-Py], [4756: 2-OEt-4-Py], [4757: 3-Cl-2-OEt-4-Py], [4758: 5-Cl-2-OEt-4-Py], [4759: 6-Cl-2-OEt-4-Py], [4760 : 3-Me-2-OEt-4-Py], [4761: 5-Me-2-OEt-4-Py], [4762: 6-Me-2-OEt-4-Py], [4763: 3 -CF3-2-OEt-4-Py], [4764: 5-CF3-2-OEt-4-Py], [4765: 6-CF3-2-OEt-4-Py], [4766: 3-CN -2 -OEt-4-Py], [4767: 5-CN-2-OEt-4-Py], [47 8: 6-CN-2-OEt-4-Py], [4769: 3-OMe-2-OEt-4-Py], [4770: 5-OMe-2-OEt-4-Py], [4771: 6-OMe-2-OEt-4-Py], [4772: 5-OEt-4-Py], [4773: 3-Cl-5-OEt-4-Py], [4774: 2-Cl-5 OEt-4-Py], [4775: 6-Cl-5-OEt-4-Py], [4776: 3-Me-5-OEt-4-Py], [4777: 2-Me-5-OEt- 4-Py], [4778: 6-Me-5-OEt-4-Py], [4779: 3-CF3-5-OEt-4-Py], [4780: 2-CF3-5-OEt-4- Py], [4781: 6-CF3-5-OEt-4-Py], [4782: 3-CN-5-O. Et-4-Py], [4783: 2-CN-5-OEt-4-Py], [4784: 6-CN-5-OEt-4-Py], [4785: 3-OMe-5-OEt- 4-Py], [4786: 2-OMe-5-OEt-4-Py], [4787: 6-OMe-5-OEt-4-Py], [4788: 6-OEt-4-Py], [ 4789: 3-Cl-6-OEt-4-Py], [4790: 2-Cl-6-OEt-4-Py], [4791: 5-Cl-6-OEt-4-Py], [4792: 3-Me-6-OEt-4-Py], [4793: 2-Me-6-OEt-4-Py], [4794: 5-Me-6-OEt-4-Py], [4795: 3- CF3-6-OEt-4-Py], [4796: 2-CF3-6-OEt-4-Py], [4 97: 5-CF3-6-OEt-4-Py], [4798: 3-CN-6-OEt-4-Py], [4799: 2-CN-6-OEt-4-Py], [4800: 5-CN-6-OEt-4-Py],

[4801: 3-OMe-6-OEt-4-Py], [4802: 2-OMe-6-OEt-4-Py], [4803: 5-OMe-6-OEt-4-Py], [4804 : 3-OCH2CF3-4-Py], [4805: 2-Cl-3-OCH2CF3-4-Py], [4806: 5-Cl-3-OCH2CF3-4-Py], [4807: 6-Cl-3] -OCH2CF3-4-Py], [4808: 2-Me-3-OCH2CF3-4-Py], [4809: 5-Me-3-OCH2CF3-4-Py], [4810: 6-Me-3-OCH2CF3 -4-Py], [4811: 2-CF3-3-OCH2CF3-4-Py], [4812: 5-CF3-3-OCH2CF3-4-Py], [4813: 6-CF3-3-OCH2CF3 4-Py], [4814: 2-CN-3-OCH2CF3-4-Py], [4815: 5-CN-3-OCH2CF3-4-Py], [4816: 6-CN-3-OCH2CF3-4- Py], [4817: 2-OMe-3-OCH2CF3-4-Py], [4818: 5-OMe-3-OCH2CF3-4-Py], [4819: 6-OMe-3-OCH2CF3-4-Py] [4820: 2-OCH2CF3-4-Py], [4821: 3-Cl-2-OCH2CF3-4-Py], [4822: 5-Cl-2-OCH2CF3-4-Py], [4823: 6- Cl-2-OCH2CF3-4-Py], [4824: 3-Me-2-OCH2CF3-4-Py], [4825: 5-Me-2-OCH2CF3-4-Py], [482 : 6-Me-2-OCH2CF3-4-Py], [4827: 3-CF3-2-OCH2CF3-4-Py], [4828: 5-CF3-2-OCH2CF3-4-Py], [4829: 6 -CF3-2-OCH2CF3-4-Py], [4830: 3-CN-2-OCH2CF3-4-Py], [4831: 5-CN-2-OCH2CF3-4-Py], [4832: 6-CN -2-OCH2CF3-4-Py], [4833: 3-OMe-2-OCH2CF3-4-Py], [4834: 5-OMe-2-OCH2CF3-4-Py], [4835: 6-OMe-2 -OCH2CF3-4-Py], [4836: 5-OCH2CF3-4-Py], [4837: 3-Cl-5-OCH2CF3-4-Py], [4838: 2-Cl-5 OCH2CF3-4-Py], [4839: 6-Cl-5-OCH2CF3-4-Py], [4840: 3-Me-5-OCH2CF3-4-Py], [4841: 2-Me-5-OCH2CF3- 4-Py], [4842: 6-Me-5-OCH2CF3-4-Py], [4843: 3-CF3-5-OCH2CF3-4-Py], [4844: 2-CF3-5-OCH2CF3-4- Py], [4845: 6-CF3-5-OCH2CF3-4-Py], [4846: 3-CN-5-OCH2CF3-4-Py], [4847: 2-CN-5-OCH2CF3-4-Py] [4848: 6-CN-5-OCH2CF3-4-Py], [4849: 3-OMe-5-OCH2CF3-4-Py], [4850: 2-OMe-5-OCH2 F3-4-Py], [4851: 6-OMe-5-OCH2CF3-4-Py], [4852: 6-OCH2CF3-4-Py], [4853: 3-Cl-6-OCH2CF3-4-Py] [4854: 2-Cl-6-OCH2CF3-4-Py], [4855: 5-Cl-6-OCH2CF3-4-Py], [4856: 3-Me-6-OCH2CF3-4-Py], [ 4857: 2-Me-6-OCH2CF3-4-Py], [4858: 5-Me-6-OCH2CF3-4-Py], [4859: 3-CF3-6-OCH2CF3-4-Py], [4860: 2-CF3-6-OCH2CF3-4-Py], [4861: 5-CF3-6-OCH2CF3-4-Py], [4862: 3-CN-6-OCH2CF3-4-Py], 4863: 2-CN-6-OCH2CF3-4-Py], [4864: 5-CN-6-OCH2CF3-4-Py], [4865: 3-OMe-6-OCH2CF3-4-Py], [4866: 2-OMe-6-OCH2CF3-4-Py], [4867: 5-OMe-6-OCH2CF3-4-Py], [4868: 3-Pr-4-Py], [4869: 2-Cl-3- Pr-4-Py], [4870: 5-Cl-3-Pr-4-Py], [4871: 6-Cl-3-Pr-4-Py], [4872: 2-Me-3-Pr- 4-Py], [4873: 5-Me-3-Pr-4-Py], [4874: 6-Me-3-Pr-4-Py], [4875: 2-CF3-3-Pr-4- Py], [4876: 5-CF3-3-3-Pr-4-Py], [ 4877: 6-CF3-3-Pr-4-Py], [4878: 2-CN-3-Pr-4-Py], [4879: 5-CN-3-Pr-4-Py], [4880: 6-CN-3-Pr-4-Py], [4881: 2-OMe-3-Pr-4-Py], [4882: 5-OMe-3-Pr-4-Py], [4883: 6- OMe-3-Pr-4-Py], [4884: 2-Pr-4-Py], [4885: 3-Cl-2-Pr-4-Py], [4886: 5-Cl-2-Pr- 4-Py], [4887: 6-Cl-2-Pr-4-Py], [4888: 3-Me-2-Pr-4-Py], [4889: 5-Me-2-Pr-4- Py], [4890: 6-Me-2-Pr-4-Py], [4891: 3-CF3-2-Pr-4-Py], [489 : 5-CF3-2-Pr-4-Py], [4893: 6-CF3-2-Pr-4-Py], [4894: 3-CN-2-Pr-4-Py], [4895: 5 -CN-2-Pr-4-Py], [4896: 6-CN-2-Pr-4-Py], [4897: 3-OMe-2-Pr-4-Py], [4898: 5-OMe -2-Pr-4-Py], [4899: 6-OMe-2-Pr-4-Py], [4900: 5-Pr-4-Py],

[4901: 3-Cl-5-Pr-4-Py], [4902: 2-Cl-5-Pr-4-Py], [4903: 6-Cl-5-Pr-4-Py], [4904 : 3-Me-5-Pr-4-Py], [4905: 2-Me-5-Pr-4-Py], [4906: 6-Me-5-Pr-4-Py], [4907: 3 -CF3-5-Pr-4-Py], [4908: 2-CF3-5-Pr-4-Py], [4909: 6-CF3-5-Pr-4-Py], [4910: 3-CN -5-Pr-4-Py], [4911: 2-CN-5-Pr-4-Py], [4912: 6-CN-5-Pr-4-Py], [4913: 3-OMe-5. -Pr-4-Py], [4914: 2-OMe-5-Pr-4-Py], [4915: 6-OMe-5-Pr-4-P ], [4916: 6-Pr-4-Py], [4917: 3-Cl-6-Pr-4-Py], [4918: 2-Cl-6-Pr-4-Py], [4919: 5]. -Cl-6-Pr-4-Py], [4920: 3-Me-6-Pr-4-Py], [4921: 2-Me-6-Pr-4-Py], [4922: 5-Me. -6-Pr-4-Py], [4923: 3-CF3-6-Pr-4-Py], [4924: 2-CF3-6-Pr-4-Py], [4925: 5-CF3-6. -Pr-4-Py], [4926: 3-CN-6-Pr-4-Py], [4927: 2-CN-6-Pr-4-Py], [4928: 5-CN-6-Pr -4-Py], [4929: 3-OMe-6-Pr-4-Py], [4930: 2-OMe-6-Pr-4-Py], 4931: 5-OMe-6-Pr-4-Py], [4932: 3-OPr-4-Py], [4933: 2-Cl-3-OPr-4-Py], [4934: 5-Cl- 3-OPr-4-Py], [4935: 6-Cl-3-OPr-4-Py], [4936: 2-Me-3-OPr-4-Py], [4937: 5-Me-3- OPr-4-Py], [4938: 6-Me-3-OPr-4-Py], [4939: 2-CF3-3-OPr-4-Py], [4940: 5-CF3-3-OPr- 4-Py], [4941: 6-CF3-3-OPr-4-Py], [4942: 2-CN-3-OPr-4-Py], [4943: 5-CN-3-OPr-4- Py], [4944: 6-CN-3-OPr-4-Py], [4945: 2-OMe-3- OPr-4-Py], [4946: 5-OMe-3-OPr-4-Py], [4947: 6-OMe-3-OPr-4-Py], [4948: 2-OPr-4-Py] [4949: 3-Cl-2-OPr-4-Py], [4950: 5-Cl-2-OPr-4-Py], [4951: 6-Cl-2-OPr-4-Py], [ 4952: 3-Me-2-OPr-4-Py], [4953: 5-Me-2-OPr-4-Py], [4954: 6-Me-2-OPr-4-Py], [4955: 3-CF3-2-OPr-4-Py], [4956: 5-CF3-2-OPr-4-Py], [4957: 6-CF3-2-OPr-4-Py], [4958: 3- CN-2-OPr-4-Py], [4959: 5-CN-2-OPr-4-Py], [ 960: 6-CN-2-OPr-4-Py], [4961: 3-OMe-2-OPr-4-Py], [4962: 5-OMe-2-OPr-4-Py], [4963: 6-OMe-2-OPr-4-Py], [4964: 5-OPr-4-Py], [4965: 3-Cl-5-OPr-4-Py], [4966: 2-Cl-5 OPr-4-Py], [4967: 6-Cl-5-OPr-4-Py], [4968: 3-Me-5-OPr-4-Py], [4969: 2-Me-5-OPr- 4-Py], [4970: 6-Me-5-OPr-4-Py], [4971: 3-CF3-5-OPr-4-Py], [4972: 2-CF3-5-OPr-4- Py], [4973: 6-CF3-5-OPr-4-Py], [4974: 3-CN- -OPr-4-Py], [4975: 2-CN-5-OPr-4-Py], [4976: 6-CN-5-OPr-4-Py], [4977: 3-OMe-5-OPr -4-Py], [4978: 2-OMe-5-OPr-4-Py], [4799: 6-OMe-5-OPr-4-Py], [4980: 6-OPr-4-Py], [4981: 3-Cl-6-OPr-4-Py], [4982: 2-Cl-6-OPr-4-Py], [4983: 5-Cl-6-OPr-4-Py], [4984 : 3-Me-6-OPr-4-Py], [4985: 2-Me-6-OPr-4-Py], [4986: 5-Me-6-OPr-4-Py], [4987: 3 -CF3-6-OPr-4-Py], [4988: 2-CF3-6-OPr-4-Py], [4989: 5-CF3-6-OPr-4-Py], [4990: 3-CN-6-OPr-4-Py], [4991: 2-CN-6-OPr-4-Py], [4992 : 5-CN-6-OPr-4-Py], [4993: 3-OMe-6-OPr-4-Py], [4994: 2-OMe-6-OPr-4-Py], [4995: 5. -OMe-6-OPr-4-Py], [4996: 3-SMe-4-Py], [4997: 2-Cl-3-SMe-4-Py], [4998: 5-Cl-3-SMe -4-Py], [4999: 6-Cl-3-SMe-4-Py], [5000: 2-Me-3-SMe-4-Py],

[5001: 5-Me-3-SMe-4-Py], [5002: 6-Me-3-SMe-4-Py], [5003: 2-CF3-3-SMe-4-Py], [5004 : 5-CF3-3-SMe-4-Py], [5005: 6-CF3-3-SMe-4-Py], [5006: 2-CN-3-SMe-4-Py], [5007: 5 -CN-3-SMe-4-Py], [5008: 6-CN-3-SMe-4-Py], [5009: 2-OMe-3-SMe-4-Py], [5010: 5-OMe -3-SMe-4-Py], [5011: 6-OMe-3-SMe-4-Py], [5012: 2-SMe-4-Py], [5013: 3-Cl-2-SMe-4 -Py], [5014: 5-Cl-2-SMe-4-Py], [5015: 6-Cl 2-SMe-4-Py], [5016: 3-Me-2-SMe-4-Py], [5017: 5-Me-2-SMe-4-Py], [5018: 6-Me-2-] SMe-4-Py], [5019: 3-CF3-2-SMe-4-Py], [5020: 5-CF3-2-SMe-4-Py], [5021: 6-CF3-2-SMe- 4-Py], [5022: 3-CN-2-SMe-4-Py], [5023: 5-CN-2-SMe-4-Py], [5024: 6-CN-2-SMe-4- Py], [5025: 3-OMe-2-SMe-4-Py], [5026: 5-OMe-2-SMe-4-Py], [5027: 6-OMe-2-SMe-4-Py] [5028: 5-SMe-4-Py], [5029: 3-Cl-5-SMe-4-P ], [5030: 2-Cl-5-SMe-4-Py], [5031: 6-Cl-5-SMe-4-Py], [5032: 3-Me-5-SMe-4-Py], [5033: 2-Me-5-SMe-4-Py], [5034: 6-Me-5-SMe-4-Py], [5035: 3-CF3-5-SMe-4-Py], [5036 : 2-CF3-5-SMe-4-Py], [5037: 6-CF3-5-SMe-4-Py], [5038: 3-CN-5-SMe-4-Py], [5039: 2 -CN-5-SMe-4-Py], [5040: 6-CN-5-SMe-4-Py], [5041: 3-OMe-5-SMe-4-Py], [5042: 2-OMe -5-SMe-4-Py], [5043: 6-OMe-5-SMe-4-Py], [50 44: 6-SMe-4-Py], [5045: 3-Cl-6-SMe-4-Py], [5046: 2-Cl-6-SMe-4-Py], [5047: 5-Cl- 6-SMe-4-Py], [5048: 3-Me-6-SMe-4-Py], [5049: 2-Me-6-SMe-4-Py], [5050: 5-Me-6-6 SMe-4-Py], [5051: 3-CF3-6-SMe-4-Py], [5052: 2-CF3-6-SMe-4-Py], [5053: 5-CF3-6-SMe- 4-Py], [5054: 3-CN-6-SMe-4-Py], [5055: 2-CN-6-SMe-4-Py], [5056: 5-CN-6-SMe-4- Py], [5057: 3-OMe-6-SMe-4-Py], [5058: 2-OMe-6-S e-4-Py], [5059: 5-OMe-6-SMe-4-Py], [5060: 3-SCF3-4-Py], [5061: 2-Cl-3-SCF3-4-Py] [5062: 5-Cl-3-SCF3-4-Py], [5063: 6-Cl-3-SCF3-4-Py], [5064: 2-Me-3-SCF3-4-Py], [ 5065: 5-Me-3-SCF3-4-Py], [5066: 6-Me-3-SCF3-4-Py], [5067: 2-CF3-3-SCF3-4-Py], [5068: 5-CF3-3-SCF3-4-Py], [5069: 6-CF3-3-SCF3-4-Py], [5070: 2-CN-3-SCF3-4-Py], [5071: 5- CN-3-SCF3-4-Py], [5072: 6-CN-3-S F3-4-Py], [5073: 2-OMe-3-SCF3-4-Py], [5074: 5-OMe-3-SCF3-4-Py], [5075: 6-OMe-3-SCF3- 4-Py], [5076: 2-SCF3-4-Py], [5077: 3-Cl-2-SCF3-4-Py], [5078: 5-Cl-2-SCF3-4-Py], [ 5079: 6-Cl-2-SCF3-4-Py], [5080: 3-Me-2-SCF3-4-Py], [5081: 5-Me-2-SCF3-4-Py], [5082: 6-Me-2-SCF3-4-Py], [5083: 3-CF3-2-SCF3-4-Py], [5084: 5-CF3-2-SCF3-4-Py], [5085: 6- CF3-2-SCF3-4-Py], [5086: 3-CN- 2-SCF3-4-Py], [5087: 5-CN-2-SCF3-4-Py], [5088: 6-CN-2-SCF3-4-Py], [5089: 3-OMe-2- SCF3-4-Py], [5090: 5-OMe-2-SCF3-4-Py], [5091: 6-OMe-2-SCF3-4-Py], [5092: 5-SCF3-4-Py] [5093: 3-Cl-5-SCF3-4-Py], [5094: 2-Cl-5-SCF3-4-Py], [5095: 6-Cl-5-SCF3-4-Py], [ 5096: 3-Me-5-SCF3-4-Py], [5097: 2-Me-5-SCF3-4-Py], [5098: 6-Me-5-SCF3-4-Py], [5099: 3-CF3-5-SCF3-4-Py], [5100: 2-C 3-5-SCF3-4-Py],

[5101: 6-CF3-5-SCF3-4-Py], [5102: 3-CN-5-SCF3-4-Py], [5103: 2-CN-5-SCF3-4-Py], [5104 : 6-CN-5-SCF3-4-Py], [5105: 3-OMe-5-SCF3-4-Py], [5106: 2-OMe-5-SCF3-4-Py], [5107: 6 -OMe-5-SCF3-4-Py], [5108: 6-SCF3-4-Py], [5109: 3-Cl-6-SCF3-4-Py], [5110: 2-Cl-6-SCF3 -4-Py], [5111: 6-Cl-6-SCF3-4-Py], [5112: 3-Me-6-SCF3-4-Py], [5113: 2-Me-6-SCF3-4 -Py], [5114: 6-Me-6-SCF3-4-Py [5115: 3-CF3-6-SCF3-4-Py], [5116: 2-CF3-6-SCF3-4-Py], [5117: 6-CF3-6-SCF3-4-Py], [ 5118: 3-CN-6-SCF3-4-Py], [5119: 2-CN-6-SCF3-4-Py], [5120: 6-CN-6-SCF3-4-Py], [5121: 3-OMe-6-SCF3-4-Py], [5122: 2-OMe-6-SCF3-4-Py], [5123: 6-OMe-6-SCF3-4-Py], [5124: 3- S (O) Me-4-Py], [5125: 2-Cl-3-S (O) Me-4-Py], [5126: 5-Cl-3-S (O) Me-4-Py] [5127: 6-Cl-3-S (O) Me-4-Py], [5128: 2-Me. 3-S (O) Me-4-Py], [5129: 5-Me-3-S (O) Me-4-Py], [5130: 6-Me-3-S (O) Me-4- Py], [5131: 2-CF3-3-S (O) Me-4-Py], [5132: 5-CF3-3-S (O) Me-4-Py], [5133: 6-CF3- 3-S (O) Me-4-Py], [5134: 2-CN-3-S (O) Me-4-Py], [5135: 5-CN-3-S (O) Me-4- Py], [5136: 6-CN-3-S (O) Me-4-Py], [5137: 2-OMe-3-S (O) Me-4-Py], [5138: 5-OMe- 3-S (O) Me-4-Py], [5139: 6-OMe-3-S (O) Me-4-Py], [5140: 2-S (O) Me-4-Py], [ 5141 : 3-Cl-2-S (O) Me-4-Py], [5142: 5-Cl-2-S (O) Me-4-Py], [5143: 6-Cl-2-S (O ) Me-4-Py], [5144: 3-Me-2-S (O) Me-4-Py], [5145: 5-Me-2-S (O) Me-4-Py], [5146 : 6-Me-2-S (O) Me-4-Py], [5147: 3-CF3-2-S (O) Me-4-Py], [5148: 5-CF3-2-S (O ) Me-4-Py], [5149: 6-CF3-2-S (O) Me-4-Py], [5150: 3-CN-2-S (O) Me-4-Py], [5151. : 5-CN-2-S (O) Me-4-Py], [5152: 6-CN-2-S (O) Me-4-Py], [5153: 3-OMe-2-S (O ) Me-4- y], [5154: 5-OMe-2-S (O) Me-4-Py], [5155: 6-OMe-2-S (O) Me-4-Py], [5156: 5-S ( O) Me-4-Py], [5157: 3-Cl-5-S (O) Me-4-Py], [5158: 2-Cl-5-S (O) Me-4-Py], [ 5159: 6-Cl-5-S (O) Me-4-Py], [5160: 3-Me-5-S (O) Me-4-Py], [5161: 2-Me-5-S ( O) Me-4-Py], [5162: 6-Me-5-S (O) Me-4-Py], [5163: 3-CF3-5-S (O) Me-4-Py], [ 5164: 2-CF3-5-S (O) Me-4-Py], [5165: 6-CF3-5-S (O) Me-4-Py], [5166: 3-CN-5-S ( O) e-4-Py], [5167: 2-CN-5-S (O) Me-4-Py], [5168: 6-CN-5-S (O) Me-4-Py], [5169: 3-OMe-5-S (O) Me-4-Py], [5170: 2-OMe-5-S (O) Me-4-Py], [5171: 6-OMe-5-S (O) Me-4-Py], [5172: 6-S (O) Me-4-Py], [5173: 3-Cl-6-S (O) Me-4-Py], [5174: 2-Cl- 6-S (O) Me-4-Py], [5175: 5-Cl-6-S (O) Me-4-Py], [5176: 3-Me-6-S (O) Me-4-. Py], [5177: 2-Me-6-S (O) Me-4-Py], [5178: 5-Me-6-S (O) Me-4-Py], [5179: 3-CF3- 6-S (O) Me-4-Py], [5180: 2-CF3-6-S (O) Me-4-Py], [5181: 5-CF3-6-S (O) Me-4-Py], [5182: 3-CN-6-S (O) Me-4-Py], [5183: 2-CN-6-S (O) Me-4-Py], [5184: 5-CN-6-S (O) Me-4-Py], [5185: 3-OMe-6-S (O) Me-4-Py], [5186: 2-OMe-6-S (O) Me-4-Py], [5187: 5-OMe-6-S (O) Me-4-Py], [5188: 3-S (O) CF3-4-Py], [5189: 2-Cl-3-S (O) CF3 -4-Py], [5190: 5-Cl-3-S (O) CF3-4-Py], [5191: 6-Cl-3-S (O) CF3-4-Py], [5192 2-Me-3-S (O) CF3-4-Py], [5193: 5-Me-3-S (O) CF3-4-Py], [5194: 6-Me-3-S (O) CF3-4-Py], [5195: 2-CF3-3-S (O) CF3-4-Py], [5196: 5-CF3-3-S (O) CF3-4-Py], [5197: 6-CF3-3-S (O) CF3-4-Py], [5198: 2-CN-3-S (O) CF3-4-Py], [5199: 5-CN-3-S (O) CF3-4-Py], [5200: 6-CN-3-S (O) CF3-4-Py],

[5201: 2-OMe-3-S (O) CF3-4-Py], [5202: 5-OMe-3-S (O) CF3-4-Py], [5203: 6-OMe-3-S (O) CF3-4-Py], [5204: 2-S (O) CF3-4-Py], [5205: 3-Cl-2-S (O) CF3-4-Py], [5206: 5 -Cl-2-S (O) CF3-4-Py], [5207: 6-Cl-2-S (O) CF3-4-Py], [5208: 3-Me-2-S (O) CF3 -4-Py], [5209: 5-Me-2-S (O) CF3-4-Py], [5210: 6-Me-2-S (O) CF3-4-Py], [5211: 3 -CF3-2-S (O) CF3-4-Py], [5212: 5-CF3-2-S (O) CF3-4-Py], [5213: 6-C 3-2-S (O) CF3-4-Py], [5214: 3-CN-2-S (O) CF3-4-Py], [5215: 5-CN-2-S (O) CF3- 4-Py], [5216: 6-CN-2-S (O) CF3-4-Py], [5217: 3-OMe-2-S (O) CF3-4-Py], [5218: 5- OMe-2-S (O) CF3-4-Py], [5219: 6-OMe-2-S (O) CF3-4-Py], [5220: 5-S (O) CF3-4-Py] [5221: 3-Cl-5-S (O) CF3-4-Py], [5222: 2-Cl-5-S (O) CF3-4-Py], [5223: 6-Cl-5- S (O) CF3-4-Py], [5224: 3-Me-5-S (O) CF3-4-Py], [5225: 2-Me-5-S (O) CF -4-Py], [5226: 6-Me-5-S (O) CF3-4-Py], [5227: 3-CF3-5-S (O) CF3-4-Py], [5228: 2 -CF3-5-S (O) CF3-4-Py], [5229: 6-CF3-5-S (O) CF3-4-Py], [5230: 3-CN-5-S (O) CF3. -4-Py], [5231: 2-CN-5-S (O) CF3-4-Py], [5232: 6-CN-5-S (O) CF3-4-Py], [5233: 3. -OMe-5-S (O) CF3-4-Py], [5234: 2-OMe-5-S (O) CF3-4-Py], [5235: 6-OMe-5-S (O) CF3 -4-Py], [5236: 6-S (O) CF3-4-Py], [5237: 3-Cl-6-S (O) CF3-4-Py], [ 5238: 2-Cl-6-S (O) CF3-4-Py], [5239: 5-Cl-6-S (O) CF3-4-Py], [5240: 3-Me-6-S ( O) CF3-4-Py], [5241: 2-Me-6-S (O) CF3-4-Py], [5242: 5-Me-6-S (O) CF3-4-Py], [ 5243: 3-CF3-6-S (O) CF3-4-Py], [5244: 2-CF3-6-S (O) CF3-4-Py], [5245: 5-CF3-6-S ( O) CF3-4-Py], [5246: 3-CN-6-S (O) CF3-4-Py], [5247: 2-CN-6-S (O) CF3-4-Py], [ 5248: 5-CN-6-S (O) CF3-4-Py], [5249: 3-OMe-6-S (O) CF3-4-Py], [5250: -OMe-6-S (O) CF3-4-Py], [5251: 5-OMe-6-S (O) CF3-4-Py], [5252: 3-S (O) 2Me-4-Py ], [5253: 2-Cl-3-S (O) 2Me-4-Py], [5254: 5-Cl-3-S (O) 2Me-4-Py], [5255: 6-Cl-3]. -S (O) 2Me-4-Py], [5256: 2-Me-3-S (O) 2Me-4-Py], [5257: 5-Me-3-S (O) 2Me-4-Py]. ], [5258: 6-Me-3-S (O) 2Me-4-Py], [5259: 2-CF3-3-S (O) 2Me-4-Py], [5260: 5-CF3-3. -S (O) 2Me-4-Py], [5261: 6-CF3-3-3-S (O) 2Me-4-Py], [5262: 2-CN-3-S ( ) 2Me-4-Py], [5263: 5-CN-3-S (O) 2Me-4-Py], [5264: 6-CN-3-S (O) 2Me-4-Py], [5265] : 2-OMe-3-S (O) 2Me-4-Py], [5266: 5-OMe-3-S (O) 2Me-4-Py], [5267: 6-OMe-3-S (O ) 2Me-4-Py], [5268: 2-S (O) 2Me-4-Py], [5269: 3-Cl-2-S (O) 2Me-4-Py], [5270: 5-Cl -2 -S (O) 2Me-4-Py], [5271: 6-Cl-2-S (O) 2Me-4-Py], [5272: 3-Me-2-S (O) 2Me-4 -Py], [5273: 5-Me-2-S (O) 2Me-4-Py], [5274: 6-Me-2-S (O) 2Me-4-Py], [5275: 3-CF3-2-S (O) 2Me-4-Py], [5276: 5-CF3-2-S (O) 2Me-4-Py], [5277: 6-CF3-2-S (O) 2Me-4-Py], [5278: 3-CN-2-S (O) 2Me-4-Py], [5279: 5-CN-2-S (O) 2Me-4-Py], [5280: 6-CN-2-S (O) 2Me-4-Py], [5281: 3-OMe-2-S (O) 2Me-4-Py], [5282: 5-OMe-2-S (O) 2Me-4-Py], [5283: 6-OMe-2-S (O) 2Me-4-Py], [5284: 5-S (O) 2Me-4-Py], [5285: 3. -Cl-5-S (O) 2Me-4-Py], [5286: 2-Cl-5-S (O) 2Me-4-Py], [5287: 6- l-5-S (O) 2Me-4-Py], [5288: 3-Me-5-S (O) 2Me-4-Py], [5289: 2-Me-5-S (O) 2Me- 4-Py], [5290: 6-Me-5-S (O) 2Me-4-Py], [5291: 3-CF3-5-S (O) 2Me-4-Py], [5292: 2- CF3-5-S (O) 2Me-4-Py], [5293: 6-CF3-5-S (O) 2Me-4-Py], [5294: 3-CN-5-S (O) 2Me- 4-Py], [5295: 2-CN-5-S (O) 2Me-4-Py], [5296: 6-CN-5-S (O) 2Me-4-Py], [5297: 3- OMe-5-S (O) 2Me-4-Py], [5298: 2-OMe-5-S (O) 2Me-4-Py], [5299: 6-OMe- -S (O) 2Me-4-Py], [5300: 6-S (O) 2Me-4-Py],

[5301: 3-Cl-6-S (O) 2Me-4-Py], [5302: 2-Cl-6-S (O) 2Me-4-Py], [5303: 5-Cl-6-S (O) 2Me-4-Py], [5304: 3-Me-6-S (O) 2Me-4-Py], [5305: 2-Me-6-S (O) 2Me-4-Py], [5306: 5-Me-6-S (O) 2Me-4-Py], [5307: 3-CF3-6-S (O) 2Me-4-Py], [5308: 2-CF3-6-S (O) 2Me-4-Py], [5309: 5-CF3-6-S (O) 2Me-4-Py], [5310: 3-CN-6-S (O) 2Me-4-Py], [5311: 2-CN-6-S (O) 2Me-4-Py], [5312: 5-CN-6-S (O) 2Me-4-Py], [5313: -OMe-6-S (O) 2Me-4-Py], [5314: 2-OMe-6-S (O) 2Me-4-Py], [5315: 5-OMe-6-S (O) 2Me -4-Py], [5316: 3-S (O) 2CF3-4-Py], [5317: 2-Cl-3-S (O) 2CF3-4-Py], [5318: 5-Cl-3 -S (O) 2CF3-4-Py], [5319: 6-Cl-3-S (O) 2CF3-4-Py], [5320: 2-Me-3-S (O) 2CF3-4-Py ], [5321: 5-Me-3-S (O) 2CF3-4-Py], [5322: 6-Me-3-S (O) 2CF3-4-Py], [5323: 2-CF3-3]. -S (O) 2CF3-4-Py], [5324: 5-CF3-3-S (O) 2CF3-4-Py], [5325: -CF3-3-S (O) 2CF3-4-Py], [5326: 2-CN-3-S (O) 2CF3-4-Py], [5327: 5-CN-3-S (O) 2CF3 -4-Py], [5328: 6-CN-3-S (O) 2CF3-4-Py], [5329: 2-OMe-3-S (O) 2CF3-4-Py], [5330: 5. -OMe-3-S (O) 2CF3-4-Py], [5331: 6-OMe-3-S (O) 2CF3-4-Py], [5332: 2-S (O) 2CF3-4-Py ], [5333: 3-Cl-2-S (O) 2CF3-4-Py], [5334: 5-Cl-2-S (O) 2CF3-4-Py], [5335: 6-Cl-2. -S (O) 2CF3-4-Py], [5336: 3-Me-2-S (O) 2CF3-4-Py], [5337. : 5-Me-2-S (O) 2CF3-4-Py], [5338: 6-Me-2-S (O) 2CF3-4-Py], [5339: 3-CF3-2-S (O ) 2CF3-4-Py], [5340: 5-CF3-2-S (O) 2CF3-4-Py], [5341: 6-CF3-2-S (O) 2CF3-4-Py], [5342 : 3-CN-2-S (O) 2CF3-4-Py], [5343: 5-CN-2-S (O) 2CF3-4-Py], [5344: 6-CN-2-S (O ) 2CF3-4-Py], [5345: 3-OMe-2-S (O) 2CF3-4-Py], [5346: 5-OMe-2-S (O) 2CF3-4-Py], [5347 : 6-OMe-2-S (O) 2CF3-4-Py], [5348: 5-S (O) 2CF3-4-Py], [ 349: 3-Cl-5-S (O) 2CF3-4-Py], [5350: 2-Cl-5-S (O) 2CF3-4-Py], [5351: 6-Cl-5-S ( O) 2CF3-4-Py], [5352: 3-Me-5-S (O) 2CF3-4-Py], [5353: 2-Me-5-S (O) 2CF3-4-Py], [ 5354: 6-Me-5-S (O) 2CF3-4-Py], [5355: 3-CF3-5-S (O) 2CF3-4-Py], [5356: 2-CF3-5-S ( O) 2CF3-4-Py], [5357: 6-CF3-5-S (O) 2CF3-4-Py], [5358: 3-CN-5-S (O) 2CF3-4-Py], [ 5359: 2-CN-5-S (O) 2CF3-4-Py], [5360: 6-CN-5-S (O) 2CF3-4. Py], [5361: 3-OMe-5-S (O) 2CF3-4-Py], [5362: 2-OMe-5-S (O) 2CF3-4-Py], [5363: 6-OMe- 5-S (O) 2CF3-4-Py], [5364: 6-S (O) 2CF3-4-Py], [5365: 3-Cl-6-S (O) 2CF3-4-Py], [ 5366: 2-Cl-6-S (O) 2CF3-4-Py], [5367: 5-Cl-6-S (O) 2CF3-4-Py], [5368: 3-Me-6-S ( O) 2CF3-4-Py], [5369: 2-Me-6-S (O) 2CF3-4-Py], [5370: 5-Me-6-S (O) 2CF3-4-Py], [ 5371: 3-CF3-6-S (O) 2CF3-4-Py], [5372: 2-CF3-6-S (O) 2CF3 -4-Py], [5373: 5-CF3-6-S (O) 2CF3-4-Py], [5374: 3-CN-6-S (O) 2CF3-4-Py], [5375: 2]. -CN-6-S (O) 2CF3-4-Py], [5376: 5-CN-6-S (O) 2CF3-4-Py], [5377: 3-OMe-6-S (O) 2CF3 -4-Py], [5378: 2-OMe-6-S (O) 2CF3-4-Py], [5379: 5-OMe-6-S (O) 2CF3-4-Py], [5380: 3 -CN-4-Py], [5381: 2-Cl-3-CN-4-Py], [5342: 5-Cl-3-CN-4-Py], [5383: 6-Cl-3-CN -4-Py], [5384: 2-Me-3-CN-4-Py], [5385: 5-Me-3-CN-4-Py] [5386: 6-Me-3-CN-4-Py], [5387: 2-CF3-3-CN-4-Py], [5388: 5-CF3-3-CN-4-Py], [5389 : 6-CF3-3-CN-4-Py], [5390: 2-CN-3-CN-4-Py], [5391: 5-CN-3-CN-4-Py], [5392: 6 -CN-3-CN-4-Py], [5393: 2-OMe-3-CN-4-Py], [5394: 5-OMe-3-CN-4-Py], [5395: 6-OMe -3-CN-4-Py], [5396: 2-CN-4-Py], [5397: 3-Cl-2-CN-4-Py], [5398: 5-Cl-2-CN-4 -Py], [5399: 6-Cl-2-CN-4-Py], [5400: 3-Me-2-CN-4-Py],

[5401: 5-Me-2-CN-4-Py], [5402: 6-Me-2-CN-4-Py], [5403: 3-CF3-2-CN-4-Py], [5404 : 5-CF3-2-CN-4-Py], [5405: 6-CF3-2-CN-4-Py], [5406: 3-CN-2-CN-4-Py], [5407: 5 -CN-2-CN-4-Py], [5408: 6-CN-2-CN-4-Py], [5409: 3-OMe-2-CN-4-Py], [5410: 5-OMe -2-CN-4-Py], [5411: 6-OMe-2-CN-4-Py], [5412: 5-CN-4-Py], [5413: 3-Cl-5-CN-4 -Py], [5414: 2-Cl-5-CN-4-Py], [5415: 6-Cl-5-CN-4-Py], [5 16: 3-Me-5-CN-4-Py], [5417: 2-Me-5-CN-4-Py], [5418: 6-Me-5-CN-4-Py], [5419: 3-CF3-5-CN-4-Py], [5420: 2-CF3-5-CN-4-Py], [5421: 6-CF3-5-CN-4-Py], [5422: 3- CN-5-CN-4-Py], [5423: 2-CN-5-CN-4-Py], [5424: 6-CN-5-CN-4-Py], [5425: 3-OMe- 5-CN-4-Py], [5426: 2-OMe-5-CN-4-Py], [5427: 6-OMe-5-CN-4-Py], [5428: 6-CN-4- Py], [5429: 3-Cl-6-CN-4-Py], [5430: 2-Cl-6-CN-4-Py], [543 : 5-Cl-6-CN-4-Py], [5432: 3-Me-6-CN-4-Py], [5433: 2-Me-6-CN-4-Py], [5434: 5 -Me-6-CN-4-Py], [5435: 3-CF3-6-CN-4-Py], [5436: 2-CF3-6-CN-4-Py], [5437: 5-CF3 -6-CN-4-Py], [5438: 3-CN-6-CN-4-Py], [5439: 2-CN-6-CN-4-Py], [5440: 5-CN-6. -CN-4-Py], [5441: 3-OMe-6-CN-4-Py], [5442: 2-OMe-6-CN-4-Py], [5443: 5-OMe-6-CN. -4-Py], [5444: 3-COOMe-4-Py], [5445: 2-Cl-3-COOMe-4-Py], [ 5446: 5-Cl-3-COOMe-4-Py], [5447: 6-Cl-3-COOMe-4-Py], [5448: 2-Me-3-COOMe-4-Py], [5449: 5-Me-3-COOMe-4-Py], [5450: 6-Me-3-COOMe-4-Py], [5451: 2-CF3-3-COOMe-4-Py], [5452: 5- CF3-3-COOMe-4-Py], [5453: 6-CF3-3-COOMe-4-Py], [5454: 2-CN-3-COOMe-4-Py], [5455: 5-CN- 3-COOMe-4-Py], [5456: 6-CN-3-COOMe-4-Py], [5457: 2-OMe-3-COOMe-4-Py], [5458: 5-OMe-3- COOMe-4-Py], [545 : 6-OMe-3-COOMe-4-Py], [5460: 2-COOMe-4-Py], [5461: 3-Cl-2-COOMe-4-Py], [5462: 5-Cl-2] -COOMe-4-Py], [5463: 6-Cl-2-COOMe-4-Py], [5464: 3-Me-2-COOMe-4-Py], [5465: 5-Me-2-COOMe -4-Py], [5466: 6-Me-2-COOMe-4-Py], [5467: 3-CF3-2-COOMe-4-Py], [5468: 5-CF3-2-COOMe-4 -Py], [5469: 6-CF3-2-COOMe-4-Py], [5470: 3-CN-2-COOMe-4-Py], [5471: 5-CN-2-COOMe-4-Py ], [5472: 6-CN-2- OOMe-4-Py], [5473: 3-OMe-2-COOMe-4-Py], [5474: 5-OMe-2-COOMe-4-Py], [5475: 6-OMe-2-COOMe- 4-Py], [5476: 5-COOMe-4-Py], [5477: 3-Cl-5-COOMe-4-Py], [5478: 2-Cl-5-COOMe-4-Py], [ 5479: 6-Cl-5-COOMe-4-Py], [5480: 3-Me-5-COOMe-4-Py], [5481: 2-Me-5-COOMe-4-Py], [5482: 6-Me-5-COOMe-4-Py], [5483: 3-CF3-5-COOMe-4-Py], [5484: 2-CF3-5-COOMe-4-Py], [5485: 6- CF3-5-COOMe-4- Py], [5486: 3-CN-5-COOMe-4-Py], [5487: 2-CN-5-COOMe-4-Py], [5488: 6-CN-5-COOMe-4-Py] [5489: 3-OMe-5-COOMe-4-Py], [5490: 2-OMe-5-COOMe-4-Py], [5491: 6-OMe-5-COOMe-4-Py], [ 5492: 6-COOMe-4-Py], [5493: 3-Cl-6-COOMe-4-Py], [5494: 2-Cl-6-COOMe-4-Py], [5495: 5-Cl- 6-COOMe-4-Py], [5496: 3-Me-6-COOMe-4-Py], [5497: 2-Me-6-COOMe-4-Py], [5498: 5-Me-6 COOMe-4-Py], [5499: -CF3-6-COOMe-4-Py], [5500: 2-CF3-6-COOMe-4-Py],

[5501: 5-CF3-6-COOMe-4-Py], [5502: 3-CN-6-COOMe-4-Py], [5503: 2-CN-6-COOMe-4-Py], [5504 : 5-CN-6-COOMe-4-Py], [5505: 3-OMe-6-COOMe-4-Py], [5506: 2-OMe-6-COOMe-4-Py], [5507: 5 -OMe-6-COOMe-4-Py], [5508: 3-NO2-4-Py], [5509: 2-Cl-3-NO2-4-Py], [5510: 5-Cl-3-NO2 -4-Py], [5511: 6-Cl-3-NO2-4-Py], [5512: 2-Me-3-NO2-4-Py], [5513: 5-Me-3-NO2-4. -Py], [5514: 6-Me-3-NO2-4-Py [5515: 2-CF3-3-NO2-4-Py], [5516: 5-CF3-3-NO2-4-Py], [5517: 6-CF3-3-NO2-4-Py], [ 5518: 2-CN-3-NO2-4-Py], [5519: 5-CN-3-NO2-4-Py], [5520: 6-CN-3-NO2-4-Py], [5521: 2-OMe-3-NO2-4-Py], [5522: 5-OMe-3-NO2-4-Py], [5523: 6-OMe-3-NO2-4-Py], [5524: 2- NO2-4-Py], [5525: 3-Cl-2-NO2-4-Py], [5526: 5-Cl-2-NO2-4-Py], [5527: 6-Cl-2-NO2- 4-Py], [5528: 3-Me-2-NO2-4-Py], [5529: 5- e-2-NO2-4-Py], [5530: 6-Me-2-NO2-4-Py], [5531: 3-CF3-2-NO2-4-Py], [5532: 5-CF3- 2-NO2-4-Py], [5533: 6-CF3-2-NO2-4-Py], [5534: 3-CN-2-NO2-4-Py], [5535: 5-CN-2- NO2-4-Py], [5536: 6-CN-2-NO2-4-Py], [5537: 3-OMe-2-NO2-4-Py], [5538: 5-OMe-2-NO2- 4-Py], [5539: 6-OMe-2-NO2-4-Py], [5540: 5-NO2-4-Py], [5541: 3-Cl-5-NO2-4-Py], [ 5542: 2-Cl-5-NO2-4-Py], [5543: 6-Cl-5-NO2-4- Py], [5544: 3-Me-5-NO2-4-Py], [5545: 2-Me-5-NO2-4-Py], [5546: 6-Me-5-NO2-4-Py] [5547: 3-CF3-5-NO2-4-Py], [5548: 2-CF3-5-NO2-4-Py], [5549: 6-CF3-5-NO2-4-Py], [ 5550: 3-CN-5-NO2-4-Py], [5551: 2-CN-5-NO2-4-Py], [5552: 6-CN-5-NO2-4-Py], [5553: 3-OMe-5-NO2-4-Py], [5554: 2-OMe-5-NO2-4-Py], [5555: 6-OMe-5-NO2-4-Py], [5556: 6- NO2-4-Py], [5557: 3-Cl-6-NO2-4-Py], [5558: -Cl-6-NO2-4-Py], [5559: 5-Cl-6-NO2-4-Py], [5560: 3-Me-6-NO2-4-Py], [5561: 2-Me -6-NO2-4-Py], [5562: 5-Me-6-NO2-4-Py], [5563: 3-CF3-6-NO2-4-Py], [5564: 2-CF3-6. -NO2-4-Py], [5565: 5-CF3-6-NO2-4-Py], [5566: 3-CN-6-NO2-4-Py], [5567: 2-CN-6-NO2 -4-Py], [5568: 5-CN-6-NO2-4-Py], [5569: 3-OMe-6-NO2-4-Py], [5570: 2-OMe-6-NO2-4 -Py], [5571: 5-OMe-6-NO2-4-Py], [5572: 3-NH2 4-Py], [5573: 2-Cl-3-NH2-4-Py], [5574: 5-Cl-3-NH2-4-Py], [5575: 6-Cl-3-NH2-4- Py], [5576: 2-Me-3-NH2-4-Py], [5577: 5-Me-3-NH2-4-Py], [5578: 6-Me-3-NH2-4-Py] [5579: 2-CF3-3-NH2-4-Py], [5580: 5-CF3-3-NH2-4-Py], [5581: 6-CF3-3-NH2-4-Py], [ 5582: 2-CN-3-NH2-4-Py], [5583: 5-CN-3-NH2-4-Py], [5584: 6-CN-3-NH2-4-Py], [5585: 2-OMe-3-NH2-4-Py], [5586: 5-OMe-3-NH2-4-Py], [5587: 6-OMe-3-NH2-4-Py], [5588: 2-NH2-4-Py], [5589: 3-Cl-2-NH2-4-Py], [5590: 5-Cl -2-NH2-4-Py], [5591: 6-Cl-2-NH2-4-Py], [5592: 3-Me-2-NH2-4-Py], [5593: 5-Me-2 -NH2-4-Py], [5594: 6-Me-2-NH2-4-Py], [5595: 3-CF3-2-NH2-4-Py], [5596: 5-CF3-2-NH2 -4-Py], [5597: 6-CF3-2-NH2-4-Py], [5598: 3-CN-2-NH2-4-Py], [5599: 5-CN-2-NH2-4 -Py], [5600: 6-CN-2-NH2-4-Py],

[5601: 3-OMe-2-NH2-4-Py], [5602: 5-OMe-2-NH2-4-Py], [5603: 6-OMe-2-NH2-4-Py], [5604 : 5-NH2-4-Py], [5605: 3-Cl-5-NH2-4-Py], [5606: 2-Cl-5-NH2-4-Py], [5607: 6-Cl-5 -NH2-4-Py], [5608: 3-Me-5-NH2-4-Py], [5609: 2-Me-5-NH2-4-Py], [5610: 6-Me-5-NH2 -4-Py], [5611: 3-CF3-5-NH2-4-Py], [5612: 2-CF3-5-NH2-4-Py], [5613: 6-CF3-5-NH2-4 -Py], [5614: 3-CN-5-NH2-4-Py], [5615: 2-CN 5-NH2-4-Py], [5616: 6-CN-5-NH2-4-Py], [5617: 3-OMe-5-NH2-4-Py], [5618: 2-OMe-5 NH2-4-Py], [5619: 6-OMe-5-NH2-4-Py], [5620: 6-NH2-4-Py], [5621: 3-Cl-6-NH2-4-Py] [5622: 2-Cl-6-NH2-4-Py], [5623: 5-Cl-6-NH2-4-Py], [5624: 3-Me-6-NH2-4-Py], [ 5625: 2-Me-6-NH2-4-Py], [5626: 5-Me-6-NH2-4-Py], [5627: 3-CF3-6-NH2-4-Py], [5628: 2-CF3-6-NH2-4-Py], [5629: 5-CF3-6-NH2-4-P ], [5630: 3-CN-6-NH2-4-Py], [5631: 2-CN-6-NH2-4-Py], [5632: 5-CN-6-NH2-4-Py], [5633: 3-OMe-6-NH2-4-Py], [5634: 2-OMe-6-NH2-4-Py], [5635: 5-OMe-6-NH2-4-Py], [5636 : 3-NHMe-4-Py], [5637: 2-Cl-3-NHMe-4-Py], [5638: 5-Cl-3-NHMe-4-Py], [5639: 6-Cl-3 -NHMe-4-Py], [5640: 2-Me-3-NHMe-4-Py], [5641: 5-Me-3-NHMe-4-Py], [5642: 6-Me-3-NHMe -4-Py], [5643: 2-CF3-3-NHMe-4-Py], [5 644: 5-CF3-3-NHMe-4-Py], [5645: 6-CF3-3-NHMe-4-Py], [5646: 2-CN-3-NHMe-4-Py], [5647: 5-CN-3-NHMe-4-Py], [5648: 6-CN-3-NHMe-4-Py], [5649: 2-OMe-3-NHMe-4-Py], [5650: 5- OMe-3-NHMe-4-Py], [5651: 6-OMe-3-NHMe-4-Py], [5652: 2-NHMe-4-Py], [5653: 3-Cl-2-NHMe- 4-Py], [5654: 5-Cl-2-NHMe-4-Py], [5655: 6-Cl-2-NHMe-4-Py], [5656: 3-Me-2-NHMe-4- Py], [5657: 5-Me-2-NHMe-4-Py] [5658: 6-Me-2-NHMe-4-Py], [5659: 3-CF3-2-NHMe-4-Py], [5660: 5-CF3-2-NHMe-4-Py], [5661 : 6-CF3-2-NHMe-4-Py], [5662: 3-CN-2-NHMe-4-Py], [5663: 5-CN-2-NHMe-4-Py], [5664: 6 -CN-2-NHMe-4-Py], [5665: 3-OMe-2-NHMe-4-Py], [5666: 5-OMe-2-NHMe-4-Py], [5667: 6-OMe -2-NHMe-4-Py], [5668: 5-NHMe-4-Py], [5669: 3-Cl-5-NHMe-4-Py], [5670: 2-Cl-5-NHMe-4 -Py], [5671: 6-Cl-5-NHMe-4 Py], [5672: 3-Me-5-NHMe-4-Py], [5673: 2-Me-5-NHMe-4-Py], [5674: 6-Me-5-NHMe-4-Py] [5675: 3-CF3-5-NHMe-4-Py], [5676: 2-CF3-5-NHMe-4-Py], [5777: 6-CF3-5-NHMe-4-Py], [ 5678: 3-CN-5-NHMe-4-Py], [5679: 2-CN-5-NHMe-4-Py], [5680: 6-CN-5-NHMe-4-Py], [5681: 3-OMe-5-NHMe-4-Py], [5682: 2-OMe-5-NHMe-4-Py], [5683: 6-OMe-5-NHMe-4-Py], [5684: 6- NHMe-4-Py], [5585: 3-Cl-6-NHM e-4-Py], [5686: 2-Cl-6-NHMe-4-Py], [5687: 5-Cl-6-NHMe-4-Py], [5688: 3-Me-6-NHMe- 4-Py], [5629: 2-Me-6-NHMe-4-Py], [5690: 5-Me-6-NHMe-4-Py], [5691: 3-CF3-6-NHMe-4- Py], [5692: 2-CF3-6-NHMe-4-Py], [5663: 5-CF3-6-NHMe-4-Py], [5694: 3-CN-6-NHMe-4-Py] [5695: 2-CN-6-NHMe-4-Py], [5696: 5-CN-6-NHMe-4-Py], [5697: 3-OMe-6-NHMe-4-Py], [ 5698: 2-OMe-6-NHMe-4-Py], [5699: 5- Me-6-NHMe-4-Py], [5700: 3-NMe2-4-Py],

[5701: 2-Cl-3-NMe2-4-Py], [5702: 5-Cl-3-NMe2-4-Py], [5703: 6-Cl-3-NMe2-4-Py], [5704 : 2-Me-3-NMe2-4-Py], [5705: 5-Me-3-NMe2-4-Py], [5706: 6-Me-3-NMe2-4-Py], [5707: 2]. -CF3-3-NMe2-4-Py], [5708: 5-CF3-3-NMe2-4-Py], [5709: 6-CF3-3-NMe2-4-Py], [5710: 2-CN -3-NMe2-4-Py], [5711: 5-CN-3-NMe2-4-Py], [5712: 6-CN-3-NMe2-4-Py], [5713: 2-OMe-3 -NMe2-4-Py], [5714: 5-OMe-3-NMe -4-Py], [5715: 6-OMe-3-NMe2-4-Py], [5716: 4-NMe2-4-Py], [5717: 3-Cl-4-NMe2-4-Py], [5718: 5-Cl-4-NMe2-4-Py], [5719: 6-Cl-4-NMe2-4-Py], [5720: 3-Me-4-NMe2-4-Py], [5721 : 5-Me-4-NMe2-4-Py], [5722: 6-Me-4-NMe2-4-Py], [5723: 3-CF3-4-NMe2-4-Py], [5724: 5. -CF3-4-NMe2-4-Py], [5725: 6-CF3-4-NMe2-4-Py], [5726: 3-CN-4-NMe2-4-Py], [5727: 5-CN -4-NMe2-4-Py], [5728: 6-CN-4-N e2-4-Py], [5729: 3-OMe-4-NMe2-4-Py], [5730: 5-OMe-4-NMe2-4-Py], [5731: 6-OMe-4-NMe2- 4-Py], [5732: 5-NMe2-4-Py], [5733: 3-Cl-5-NMe2-4-Py], [5734: 2-Cl-5-NMe2-4-Py], [ 5735: 6-Cl-5-NMe2-4-Py], [5736: 3-Me-5-NMe2-4-Py], [5737: 2-Me-5-NMe2-4-Py], [5738: 6-Me-5-NMe2-4-Py], [5739: 3-CF3-5-NMe2-4-Py], [5740: 2-CF3-5-NMe2-4-Py], [5741: 6- CF3-5-NMe2-4-Py], [5742: 3-CN- 5-NMe2-4-Py], [5743: 2-CN-5-NMe2-4-Py], [5744: 6-CN-5-NMe2-4-Py], [5745: 3-OMe-5 NMe2-4-Py], [5746: 2-OMe-5-NMe2-4-Py], [5747: 6-OMe-5-NMe2-4-Py], [5748: 6-NMe2-4-Py] [5749: 3-Cl-6-NMe2-4-Py], [5750: 2-Cl-6-NMe2-4-Py], [5751: 5-Cl-6-NMe2-4-Py], [ 5752: 3-Me-6-NMe2-4-Py], [5753: 2-Me-6-NMe2-4-Py], [5754: 5-Me-6-NMe2-4-Py], [5755: 3-CF3-6-NMe2-4-Py], [5756: 2-C 3-6-NMe2-4-Py], [5757: 5-CF3-6-NMe2-4-Py], [5758: 3-CN-6-NMe2-4-Py], [5759: 2-CN- 6-NMe2-4-Py], [5760: 5-CN-6-NMe2-4-Py], [5761: 3-OMe-6-NMe2-4-Py], [5762: 2-OMe-6 NMe2-4-Py], [5763: 5-OMe-6-NMe2-4-Py], [5764: 3-ACNH-4-Py], [5765: 2-Cl-3-ACNH-4-Py] [5766: 5-Cl-3-ACNH-4-Py], [5767: 6-Cl-3-ACNH-4-Py], [5768: 2-Me-3-ACNH-4-Py], [ 5769: 5-Me-3-ACNH-4-Py], [5770: -Me-3-ACNH-4-Py], [5771: 2-CF3-3-ACNH-4-Py], [5772: 5-CF3-3-ACNH-4-Py], [5773: 6-CF3 -3-ACNH-4-Py], [5774: 2-CN-3-ACNH-4-Py], [5775: 5-CN-3-ACNH-4-Py], [5776: 6-CN-3 -ACNH-4-Py], [5777: 2-OMe-3-ACNH-4-Py], [5778: 5-OMe-3-ACNH-4-Py], [5779: 6-OMe-3-ACNH -4-Py], [5780: 2-ACNH-4-Py], [5781: 3-Cl-2-ACNH-4-Py], [5782: 5-Cl-2-ACNH-4-Py], [5783: 6-Cl-2-ACNH-4-Py], [57 84: 3-Me-2-ACNH-4-Py], [5785: 5-Me-2-ACNH-4-Py], [5786: 6-Me-2-ACNH-4-Py], [5787: 3-CF3-2-ACNH-4-Py], [5788: 5-CF3-2-ACNH-4-Py], [5789: 6-CF3-2-ACNH-4-Py], [5790: 3- CN-2-ACNH-4-Py], [5791: 5-CN-2-ACNH-4-Py], [5792: 6-CN-2-ACNH-4-Py], [5793: 3-OMe- 2-ACNH-4-Py], [5794: 5-OMe-2-ACNH-4-Py], [5795: 6-OMe-2-ACNH-4-Py], [5796: 5-ACNH-4- Py], [5797: 3-Cl-5-ACNH-4-Py] [5798: 2-Cl-5-ACNH-4-Py], [5799: 6-Cl-5-ACNH-4-Py], [5800: 3-Me-5-ACNH-4-Py]

[5801: 2-Me-5-ACNH-4-Py], [5802: 6-Me-5-ACNH-4-Py], [5803: 3-CF3-5-ACNH-4-Py], [5804 : 2-CF3-5-ACNH-4-Py], [5805: 6-CF3-5-ACNH-4-Py], [5806: 3-CN-5-ACNH-4-Py], [5807: 2 -CN-5-ACNH-4-Py], [5808: 6-CN-5-ACNH-4-Py], [5809: 3-OMe-5-ACNH-4-Py], [5810: 2-OMe -5-ACNH-4-Py], [5811: 6-OMe-5-ACNH-4-Py], [5812: 6-ACNH-4-Py], [5813: 3-Cl-6-ACNH-4 -Py], [5814: 2-Cl-6-ACNH-4- y], [5815: 5-Cl-6-ACNH-4-Py], [5816: 3-Me-6-ACNH-4-Py], [5817: 2-Me-6-ACNH-4-Py] [5818: 5-Me-6-ACNH-4-Py], [5819: 3-CF3-6-ACNH-4-Py], [5820: 2-CF3-6-ACNH-4-Py], [ 5821: 5-CF3-6-ACNH-4-Py], [5822: 3-CN-6-ACNH-4-Py], [5823: 2-CN-6-ACNH-4-Py], [5824: 5-CN-6-ACNH-4-Py], [5825: 3-OMe-6-ACNH-4-Py], [5826: 2-OMe-6-ACNH-4-Py], [5827: 5- OMe-6-ACNH-4-Py], [5828: 3- (N- CN-Me-N) -4-Py], [5829: 2-Cl-3- (N-AC-N-Me-N) -4-Py], [5830: 5-Cl-3- ( N-AC-N-Me-N) -4-Py], [5831: 6-Cl-3- (N-AC-N-Me-N) -4-Py], [5832: 2-Me-3. -(N-AC-N-Me-N) -4-Py], [5833: 5-Me-3- (N-AC-N-Me-N) -4-Py], [5834: 6-Me -3- (N-AC-N-Me-N) -4-Py], [5835: 2-CF3-3 (N-AC-N-Me-N) -4-Py], [5836: 5 -CF3-3- (N-AC-N-Me-N) -4-Py], [5837: 6-CF3-3- (N-AC-N-Me-N) -4-Py], [5838. : 2-CN-3- (NA CN-Me-N) -4-Py], [5839: 5-CN-3- (N-AC-N-Me-N) -4-Py], [5840: 6-CN-3- ( N-AC-N-Me-N) -4-Py], [5841: 2-OMe-3- (N-AC-N-Me-N) -4-Py], [5842: 5-OMe-3. -(N-AC-N-Me-N) -4-Py], [5843: 6-OMe-3- (N-AC-N-Me-N) -4-Py], [5844: 2- ( N-AC-N-Me-N) -4-Py], [5845: 3-Cl-2- (N-AC-N-Me-N) -4-Py], [5846: 5-Cl-2. -(N-AC-N-Me-N) -4-Py], [5847: 6-Cl-2- (N-AC-N-Me-N) -4-Py], [5848: 3-Me. -2- (N-AC-N-M -N) -4-Py], [5849: 5-Me-2- (N-AC-N-Me-N) -4-Py], [5850: 6-Me-2- (N-AC-N). -Me-N) -4-Py], [5851: 3-CF3-2- (N-AC-N-Me-N) -4-Py], [5852: 5-CF3-2- (N-AC). -N-Me-N) -4-Py], [5853: 6-CF3-2- (N-AC-N-Me-N) -4-Py], [5854: 3-CN-2- (N -AC-N-Me-N) -4-Py], [5855: 5-CN-2- (N-AC-N-Me-N) -4-Py], [5856: 6-CN-2- (N-AC-N-Me-N) -4-Py], [5857: 3-OMe-2- (N-AC-N-Me-N) -4-Py], [5858: 5-OMe- 2- (N-AC-N Me-N) -4-Py], [5859: 6-OMe-2- (N-AC-N-Me-N) -4-Py], [5860: 5- (N-AC-N-Me- N) -4-Py], [5861: 3-Cl-5- (N-AC-N-Me-N) -4-Py], [5862: 2-Cl-5- (N-AC-N- Me-N) -4-Py], [5863: 6-Cl-5- (N-AC-N-Me-N) -4-Py], [5864: 3-Me-5- (N-AC- N-Me-N) -4-Py], [5865: 2-Me-5- (N-AC-N-Me-N) -4-Py], [5866: 6-Me-5- (N- AC-N-Me-N) -4-Py], [5867: 3-CF3-5- (N-AC-N-Me-N) -4-Py], [5868: 2-CF3-5- ( N-AC-N-Me-N) -4-Py], [5869: 6-CF3-5- (N-AC-N-Me-N) -4-Py], [5870: 3-CN-5- (N-AC-N-Me- N) -4-Py], [5871: 2-CN-5- (N-AC-N-Me-N) -4-Py], [5872: 6-CN-5- (N-AC-N- Me-N) -4-Py], [5873: 3-OMe-5- (N-AC-N-Me-N) -4-Py], [5874: 2-OMe-5- (N-AC- N-Me-N) -4-Py], [5875: 6-OMe-5- (N-AC-N-Me-N) -4-Py], [5876: 6- (N-AC-N- Me-N) -4-Py], [5877: 3-Cl-6- (N-AC-N-Me-N) -4-Py], [5878: 2-Cl-6- (N-AC- N-Me-N) -4-P ], [5879: 5-Cl-6- (N-AC-N-Me-N) -4-Py], [5880: 3-Me-6- (N-AC-N-Me-N) -4. -Py], [5881: 2-Me-6- (N-AC-N-Me-N) -4-Py], [5882: 5-Me-6- (N-AC-N-Me-N) -4-Py], [5883: 3-CF3-6- (N-AC-N-Me-N) -4-Py], [5884: 2-CF3-6- (N-AC-N-Me- N) -4-Py], [5885: 5-CF3-6- (N-AC-N-Me-N) -4-Py], [5886: 3-CN-6- (N-AC-N- Me-N) -4-Py], [5887: 2-CN-6- (N-AC-N-Me-N) -4-Py], [5888: 5-CN-6- (N-AC- N-Me-N) -4-P ], [5889: 3-OMe-6- (N-AC-N-Me-N) -4-Py], [5890: 2-OMe-6- (N-AC-N-Me-N) -4. -Py], [5891: 5-OMe-6- (N-AC-N-Me-N) -4-Py], [5892: 3-AC-4-Py], [5893: 2-Cl-3. -AC-4-Py], [5894: 5-Cl-3-AC-4-Py], [5895: 6-Cl-3-AC-4-Py], [5896: 2-Me-3-AC. -4-Py], [5897: 5-Me-3-AC-4-Py], [5898: 6-Me-3-AC-4-Py], [5899: 2-CF3-3-AC-4. -Py], [5900: 5-CF3-3-3-AC-4-Py],

[5901: 6-CF3-3-3-AC-4-Py], [5902: 2-CN-3-AC-4-Py], [5903: 5-CN-3-AC-4-Py], [5904 : 6-CN-3-AC-4-Py], [5905: 2-OMe-3-AC-4-Py], [5906: 5-OMe-3-AC-4-Py], [5907: 6. -OMe-3-AC-4-Py], [5908: 2-AC-4-Py], [5909: 3-Cl-2-AC-4-Py], [5910: 5-Cl-2-AC -4-Py], [5911: 6-Cl-2-AC-4-Py], [5912: 3-Me-2-AC-4-Py], [5913: 5-Me-2-AC-4 -Py], [5914: 6-Me-2-AC-4-Py], [5915: 3-CF3-2-AC-4-Py], [59 6: 5-CF3-2-AC-4-Py], [5917: 6-CF3-2-AC-4-Py], [5918: 3-CN-2-AC-4-Py], [5919: 5-CN-2-AC-4-Py], [5920: 6-CN-2-AC-4-Py], [5921: 3-OMe-2-AC-4-Py], [5922: 5- OMe-2-AC-4-Py], [5923: 6-OMe-2-AC-4-Py], [5924: 5-AC-4-Py], [5925: 3-Cl-5-AC- 4-Py], [5926: 2-Cl-5-AC-4-Py], [5927: 6-Cl-5-AC-4-Py], [5928: 3-Me-5-AC-4- Py], [5929: 2-Me-5-AC-4-Py], [5930: 6-Me-5-AC-4-Py], [5931: -CF3-5-AC-4-Py], [5932: 2-CF3-5-AC-4-Py], [5933: 6-CF3-5-AC-4-Py], [5934: 3-CN. -5-AC-4-Py], [5935: 2-CN-5-AC-4-Py], [5936: 6-CN-5-AC-4-Py], [5937: 3-OMe-5. -AC-4-Py], [5938: 2-OMe-5-AC-4-Py], [5939: 6-OMe-5-AC-4-Py], [5940: 6-AC-4-Py]. ], [5941: 3-Cl-6-AC-4-Py], [5942: 2-Cl-6-AC-4-Py], [5943: 5-Cl-6-AC-4-Py], [5944: 3-Me-6-AC-4-Py], [5945: 2-Me-6-AC-4-Py], [5946: 5-M e-6-AC-4-Py], [5947: 3-CF3-6-AC-4-Py], [5948: 2-CF3-6-AC-4-Py], [5949: 5-CF3- 6-AC-4-Py], [5950: 3-CN-6-AC-4-Py], [5951: 2-CN-6-AC-4-Py], [5952: 5-CN-6 AC-4-Py], [5953: 3-OMe-6-AC-4-Py], [5954: 2-OMe-6-AC-4-Py], [5955: 5-OMe-6-AC- 4-Py], [5956: 1,2- (methylenedioxy) phenyl-4-yl], [5957: 2,3-dihydrobenzofuran-5-yl], [5958: 2,3-dihydrobenzofuran-6. -Yl], [5959: 1,3-dihydroisobenzofuran-5-yl], [5 60: benzofuran-5-yl], [5961: benzofuran-6-yl], [5962: 2,3-dihydrobenzothiophen-5-yl], [5963: 2,3-dihydrobenzothiophen-6-yl] [5964: 1,3-dihydroisobenzothiophen-5-yl], [5965: benzothiophen-5-yl], [5966: benzothiophen-6-yl], [5967: benzodioxan-4-yl]. [5968: Chroman-6-yl], [5969: Chroman-7-yl], [5970: Isochroman-6-yl], [5971: Isochroman-7-yl], [5972: Phenyl], [5973: 2-fluorophenyl], [5974: 3-fluorophenyl], [5975: 4-fluorophenyl], [5976: 2 4-difluorophenyl], [5977: 2,4,6-trifluorophenyl], [5978: 2,3,4,5,6-pentafluorophenyl], [5979: 2,3-difluorophenyl], [ 5980: 2-chlorophenyl], [5981: 3-chlorophenyl], [5982: 4-chlorophenyl], [5983: 2,3-dichlorophenyl], [5984: 2,4-dichlorophenyl], [5985: 2,5- Dichlorophenyl], [5986: 2,6-dichlorophenyl], [5987: 3,4-dichlorophenyl], [5988: 3,5-dichlorophenyl], [5989: 2,3,4-trichlorophenyl], [5990: 2 , 3,5-trichlorophenyl], [5991: 2,3,6-trichlorophenyl], [5992: 2,4,5-trichlorophenyl], [5993: 2,4,6-trichlorophenyl], [5994: 3,4,5-trichlorophenyl], [5995: 2,3,4,6-tetrachlorophenyl] [5996: 2,3,5,6-tetrachlorophenyl], [5997: 2,3,4,5,6-pentachlorophenyl], [5998: 2-bromophenyl], [5999: 3-bromophenyl]. [6000: 4-bromophenyl],

[6001: 2,4-dibromophenyl], [6002: 2,5-dibromophenyl], [6003: 2,6-dibromophenyl], [6004: 2,4,6-tribromophenyl], [6005: 2,3,4,5,6-pentabromophenyl], [6006: 2-iodophenyl], [6007: 3-iodophenyl], [6008: 4-iodophenyl], [6009: 2,4-di Iodophenyl], [6010: 2-chloro-3-fluorophenyl], [6011: 2-chloro-4-fluorophenyl], [6012: 2-chloro-5-fluorophenyl], [6013: 2-chloro- 6-fluorophenyl], [6014: 2-chloro-3-bromophenyl], [6015: 2-chloro-4-bromophenyl], [6016: 2- Ro-5-bromophenyl], [6017: 2-chloro-6-bromophenyl], [6018: 2-bromo-3-chlorophenyl], [6019: 2-bromo-4-chlorophenyl], [6020: 2- Bromo-5-chlorophenyl], [6021: 2-bromo-3-fluorophenyl], [6022: 2-bromo-4-fluorophenyl], [6023: 2-bromo-5-fluorophenyl], [6024: 2 -Bromo-6-fluorophenyl], [6025: 2-fluoro-3-chlorophenyl], [6026: 2-fluoro-4-chlorophenyl], [6027: 2-fluoro-5-chlorophenyl], [6028: 2- Fluoro-4-bromophenyl], [6029: 3-chloro-4-fluorophenyl], [6030: 3-chloro 5-fluorophenyl], [6031: 3-chloro-4-bromophenyl], [6032: 3-chloro-5-bromophenyl], [6033: 3-fluoro-4-chlorophenyl], [6034: 3-fluoro -4-bromophenyl], [6035: 3-bromo-4-chlorophenyl], [6036: 3-bromo-4-fluorophenyl], [6037: 2,6-dichloro-4-bromophenyl], [6038: 2,3-difluoro-4-chlorophenyl], [6039: 2,6-difluoro-4-chlorophenyl], [6040: 2,5-difluoro-4-chlorophenyl], [6041: 3,5-difluoro-4- Chlorophenyl], [6042: 2,3,5-trifluoro-4-chlorophenyl], [6043: 2,3,6-trifluoro Oro-4-chlorophenyl], [6044: 2,3,5,6-tetrafluoro-4-chlorophenyl], [6045: 2-fluoro-4-bromophenyl], [6046: 2,3-difluoro-4- Bromophenyl], [6047: 2,6-difluoro-4-bromophenyl], [6048: 2,5-difluoro-4-bromophenyl], [6049: 3,5-difluoro-4-bromophenyl], [ 6050: 2,3,5-trifluoro-4-bromophenyl], [6051: 2,3,6-trifluoro-4-bromophenyl], [6052: 2,3,5,6-tetrafluoro-4 -Bromophenyl], [6053: 2-fluoro-4-iodophenyl], [6054: 3-fluoro-4-iodophenyl], [6055: 2,3-diflu] Rho-4-iodophenyl], [6056: 2,6-difluoro-4-iodophenyl], [6057: 2,5-difluoro-4-iodophenyl], [6058: 3,5-difluoro-4-iodo Phenyl], [6059: 2,3,5-trifluoro-4-iodophenyl], [6060: 2,3,6-trifluoro-4-iodophenyl], [6061: 2,3,5,6- Tetrafluoro-4-iodophenyl], [6062: 2-methylphenyl], [6063: 3-methylphenyl], [6064: 4-methylphenyl], [6065: 2,3-dimethylphenyl], [6066: 2,4-dimethylphenyl], [6067: 2,5-dimethylphenyl], [6068: 2,6-dimethylphenyl], [6069: 3,4-dimethyl Enyl], [6070: 3,5-dimethylphenyl], [6071: 2,3,5-trimethylphenyl], [6072: 2,3,4-trimethylphenyl], [6073: 2,3,6-trimethyl] Phenyl], [6074: 2,4,5-trimethylphenyl], [6075: 2,4,6-trimethylphenyl], [6076: 3,4,5-trimethylphenyl], [6077: 2,3,4 , 6-tetramethylphenyl], [6078: 2,3,5,6-tetramethylphenyl], [6079: 2,3,4,5,6-pentamethylphenyl], [6080: 2-ethylphenyl] [6081: 3-ethylphenyl], [6082: 4-ethylphenyl], [6083: 2,4-diethylphenyl], [6084: 2,6-diethylphenyl] [6085: 3,5-diethylphenyl], [6086: 2,4,6-triethylphenyl], [6087: 2-n-propylphenyl], [6088: 3-n-propylphenyl], [6089: 4-n-propylphenyl], [6090: 2-isopropylphenyl], [6091: 3-isopropylphenyl], [6092: 4-isopropylphenyl], [6093: 2,4-diisopropylphenyl], [6094: 2 , 6-diisopropylphenyl], [6095: 3,5-diisopropylphenyl], [6096: 2-s-butylphenyl], [6097: 3-s-butylphenyl], [6098: 4-s-butylphenyl]. [6099: 2-t-butylphenyl], [6100: 3-t-butylphenyl],

[6101: 4-t-butylphenyl], [6102: 4-n-butylphenyl], [6103: 4-n-nonylphenyl], [6104: 2-methyl-4-t-butylphenyl], [6105 : 2-methyl-6-t-butylphenyl], [6106: 2-methyl-4-isopropylphenyl], [6107: 2-methyl-5-isopropylphenyl], [6108: 3-methyl-4-isopropylphenyl] ], [6109: 2-cyclohexylphenyl], [6111: 3-cyclohexylphenyl], [6111: 4-cyclohexylphenyl], [6112: 4-cyclopropylphenyl], [6113: 4-cyclobutylphenyl], [ 6114: 4-cyclopentylphenyl], [6115: 2-chloro-4-phenylphenyl] [6116: 2-Bromo-4-phenylphenyl], [6117: 4-hydroxyphenyl], [6118: 2-methoxyphenyl], [6119: 3-methoxyphenyl], [6120: 4-methoxyphenyl], [ 6121: 2-ethoxyphenyl], [6122: 3-ethoxyphenyl], [6123: 4-ethoxyphenyl], [6124: 2-n-propyloxyphenyl], [6125: 3-n-propyloxyphenyl], [6126: 4-n-propyloxyphenyl], [6127: 2-isopropyloxyphenyl], [6128: 3-isopropyloxyphenyl], [6129: 4-isopropyloxyphenyl], [6130: 2-n-hexyl Oxyphenyl], [6131: 3-n-hexyloxypheny ], [6132: 4-n-hexyloxyphenyl], [6133: 2-benzyloxyphenyl], [6134: 3-benzyloxyphenyl], [6135: 4-benzyloxyphenyl], [6136: 2, 3 -Dimethoxyphenyl], [6137: 2,4-dimethoxyphenyl], [6138: 2,5-dimethoxyphenyl], [6139: 2,6-dimethoxyphenyl], [6140: 3,4-dimethoxyphenyl], [ 6141: 3,5-dimethoxyphenyl], [6142: 2-t-butoxyphenyl], [6143: 3-t-butoxyphenyl], [6144: 4-t-butoxyphenyl], [6145: 3- (3 '-Chlorophenyl) phenyl], [6146: 4- (4'-chlorophenyl) phenyl], [6147: 2 -Phenoxyphenyl], [6148: 3-phenoxyphenyl], [6149: 4-phenoxyphenyl], [6150: 2- (2′-fluorophenoxy) phenyl], [6151: 3- (3′-chlorophenoxy) Phenyl], [6152: 4- (4′-chlorophenoxy) phenyl], [6153: 2,3,6-trimethyl-4-fluorophenyl], [6154: 2,3,6-trimethyl-4-chlorophenyl] [6155: 2,3,6-trimethyl-4-bromophenyl], [6156: 2,4-dimethyl-6-fluorophenyl], [6157: 2,4-dimethyl-6-chlorophenyl], [6158: 2,4-dimethyl-6-bromophenyl], [6159: 2-isopropyl-4-chloro-5-methylphenyl], [6 60: 2-chloro-4-nitrophenyl], [6161: 2-nitro-4-chlorophenyl], [6162: 2-methoxy-5-nitrophenyl], [6163: 2,4-dichloro-5-nitrophenyl] ], [6164: 2,4-dichloro-6-nitrophenyl], [6165: 2,6-dichloro-4-nitrophenyl], [6166: 2,6-dibromo-4-nitrophenyl], [6167: 2,6-diiodo-4-nitrophenyl], [6168: 2-methyl-5-isopropyl-4-chlorophenyl], [6169: 2-methoxycarbonylphenyl], [6170: 3-methoxycarbonylphenyl], [6171 : 4-methoxycarbonylphenyl], [6172: 4-acetoxyphenyl], [6173: 2-methoxymethyl. Enyl], [6174: 3-methoxymethylphenyl], [6175: 4-methoxymethylphenyl], [6176: 2-phenylphenyl], [6177: 3-phenylphenyl], [6178: 4-phenylphenyl], [6179: 2- (2′-fluorophenyl) phenyl], [6180: 2-methyl-5-bromophenyl], [6181: 2-methyl-6-bromophenyl], [6182: 2-chloro-3- Methylphenyl], [6183: 2-chloro-4-methylphenyl], [6184: 2-chloro-5-methylphenyl], [6185: 2-fluoro-3-methylphenyl], [6186: 2-fluoro- 4-methylphenyl], [6187: 2-fluoro-5-methylphenyl], [6188: 2-bromo-3-methylphenyl] Enyl], [6189: 2-bromo-4-methylphenyl], [6190: 2-bromo-5-methylphenyl], [6191: 3-methyl-4-chlorophenyl], [6192: 3-methyl-5- Chlorophenyl], [6193: 3-methyl-4-fluorophenyl], [6194: 3-methyl-5-fluorophenyl], [6195: 3-methyl-4-bromophenyl], [6196: 3-methyl-5 -Bromophenyl], [6197: 3-fluoro-4-methylphenyl], [6198: 3-chloro-4-methylphenyl], [6199: 3-bromo-4-methylphenyl], [6200: 2-chloro. -4,5-dimethylphenyl],

[6201: 2-bromo-4,5-dimethylphenyl], [6202: 2-chloro-3,5-dimethylphenyl], [6203: 2-bromo-3,5-dimethylphenyl], [6204: 2, 6-dibromo-4-methylphenyl], [6205: 2,4-dichloro-6-methylphenyl], [6206: 2,4-difluoro-6-methylphenyl], [6207: 2,4-dibromo-6 -Methylphenyl], [6208: 2,6-dimethyl-4-fluorophenyl], [6209: 2,6-dimethyl-4-chlorophenyl], [6210: 2,6-dimethyl-4-bromophenyl], [ 6211: 3,5-dimethyl-4-fluorophenyl], [6212: 3,5-dimethyl-4-chlorophenyl], [6213: 3,5-dimethyl-4-butyl Mophenyl], [6214: 2,3-difluoro-4-methylphenyl], [6215: 2,5-difluoro-4-methylphenyl], [6216: 3,5-difluoro-4-methylphenyl], [6217 : 2,3,5-trifluoro-4-methylphenyl], [6218: 2,3,6-trifluoro-4-methylphenyl], [6219: 2,3,5,6-tetrafluoro-4- Methylphenyl], [6220: 2-fluoro-4-ethylphenyl], [6221: 3-fluoro-4-ethylphenyl], [6222: 2,3-difluoro-4-ethylphenyl], [6223: 2, 6-difluoro-4-ethylphenyl], [6224: 2,5-difluoro-4-ethylphenyl], [6225: 3,5-difluoro-4-ethylphenyl] Nil], [6226: 2,3,5-trifluoro-4-ethylphenyl], [6227: 2,3,6-trifluoro-4-ethylphenyl], [6228: 2,3,5,6- Tetrafluoro-4-ethylphenyl], [6229: 2-trifluoromethylphenyl], [6230: 3-trifluoromethylphenyl], [6231: 4-trifluoromethylphenyl], [6232: 4- (2, 2,2-trifluoro-1-trifluoromethyl-ethyl) phenyl], [6233: 2-trifluoromethoxyphenyl], [6234: 3-trifluoromethoxyphenyl], [6235: 4-trifluoromethoxyphenyl] [6236: 4- (2,2-difluoroethoxy) phenyl], [6237: 4- (2,2,2-trifluoroe Toxi) phenyl], [6238: 2-nitrophenyl], [6239: 3-nitrophenyl], [6240: 4-nitrophenyl], [6241: 2-cyanophenyl], [6242: 3-cyanophenyl], [6243: 4-cyanophenyl], [6244: 2-methyl-3-chlorophenyl], [6245: 2-methyl-4-chlorophenyl], [6246: 2-methyl-5-chlorophenyl], [6247: 2- Methyl-6-chlorophenyl], [6248: 2-methyl-3-fluorophenyl], [6249: 2-methyl-4-fluorophenyl], [6250: 2-methyl-5-fluorophenyl], [6251: 2 -Methyl-6-fluorophenyl], [6252: 2-methyl-3-bromophenyl], [6253: 2-methyl. -4-bromophenyl], [6254: 4-methylthiophenyl], [6255: 4-methylsulfonylphenyl], [6256: 4-methylsulfinylphenyl], [6257: 4-trifluoromethylthiophenyl], [6258: 4-ethynylphenyl], [6259: 4- (1-propynyl) phenyl], [6260: 4-vinylphenyl], [6261: 4- (2,2-dichlorovinyl) phenyl], [6262: 4- ( 2,2-difluorovinyl) phenyl], [6263: cyclohexyl], [6264: 2-chlorocyclohexyl], [6265: 3-chlorocyclohexyl], [6266: 4-chlorocyclohexyl], [6267: 4,4- Dichlorocyclohexyl], [6268: 2-bromocyclohexyl], 6269: 3-bromocyclohexyl], [6270: 4-bromocyclohexyl], [6271: 4,4-dibromocyclohexyl], [6272: 2-iodocyclohexyl], [6273: 3-iodocyclohexyl], [6274: 4. -Iodocyclohexyl], [6275: 2-fluorocyclohexyl], [6276: 3-fluorocyclohexyl], [6277: 4-fluorocyclohexyl], [6278: 4,4-difluorocyclohexyl], [6279: 4-methylcyclohexyl. ], [6280: 4-ethylcyclohexyl], [6281: 1-cyclohexenyl], [6282: 2-cyclohexenyl], [6283: 3-cyclohexenyl], [6284: 2-chloro-1-cyclohexenyl]. , [628 : 3-chloro-1-cyclohexenyl], [6286: 4-chloro-1-cyclohexenyl], [6287: 5-chloro-1-cyclohexenyl], [6288: 6-chloro-1-cyclohexenyl], [6289: 1-chloro-2-cyclohexenyl], [6290: 2-chloro-2-cyclohexenyl], [6291: 3-chloro-2-cyclohexenyl], [6292: 4-chloro-2-cyclohexenyl] ], [6293: 5-chloro-2-cyclohexenyl], [6294: 6-chloro-2-cyclohexenyl], [6295: 1-chloro-3-cyclohexenyl], [6296: 2-chloro-3- Cyclohexenyl], [6297: 3-chloro-3-cyclohexenyl], [6298: 4-chloro-3-cyclohexenyl], [6 299: 5-chloro-3-cyclohexenyl], [6300: 6-chloro-3-cyclohexenyl],

[6301: 4-Bromo-1-cyclohexenyl], [6302: 4-Bromo-2-cyclohexenyl], [6303: 4-Bromo-3-cyclohexenyl], [6304: 4-Methyl-1-cyclohexenyl] ], [6305: 4-methyl-2-cyclohexenyl], [6306: 4-methyl-3-cyclohexenyl], [6307: 4-ethyl-1-cyclohexenyl], [6308: 4-ethyl-2- Cyclohexenyl], [6309: 4-ethyl-3-cyclohexenyl], [6310: trifluoromethyl], [6311: tert-butyl], [6312: 3-fluoro-2-methoxyphenyl], [6313: 4 -Fluoro-2-methoxyphenyl], [6314: 5-fluoro-2-methoxyphenyl], [6315: 6- [Luoro-2-methoxyphenyl], [6316: 3-chloro-2-methoxyphenyl], [6317: 4-chloro-2-methoxyphenyl], [6318: 5-chloro-2-methoxyphenyl], [6319: 6-chloro-2-methoxyphenyl], [6320: 3-bromo-2-methoxyphenyl], [6321: 4-bromo-2-methoxyphenyl], [6322: 5-bromo-2-methoxyphenyl], [ 6323: 6-Bromo-2-methoxyphenyl], [6324: 3-iodo-2-methoxyphenyl], [6325: 4-iodo-2-methoxyphenyl], [6326: 5-iodo-2-methoxyphenyl] [6327: 6-iodo-2-methoxyphenyl], [6328: 2,3-dimethoxyphenyl], [6329: 2, 4-dimethoxyphenyl], [6330: 2,5-dimethoxyphenyl], [6331: 2,6-dimethoxyphenyl], [6332: 3-methyl-2-methoxyphenyl], [6333: 4-methyl-2- Methoxyphenyl], [6334: 5-methyl-2-methoxyphenyl], [6335: 6-methyl-2-methoxyphenyl], [6336: 3-ethyl-2-methoxyphenyl], [6337: 4-ethyl- 2-methoxyphenyl], [6338: 5-ethyl-2-methoxyphenyl], [6339: 6-ethyl-2-methoxyphenyl], [6340: 3-trifluoromethoxy-2-methoxyphenyl], [6341: 4-trifluoromethoxy-2-methoxyphenyl], [6342: 5-trifluoromethoxy-2-methoxy Phenyl], [6343: 6-trifluoromethoxy-2-methoxyphenyl], [6344: 3-trifluoromethyl-2-methoxyphenyl], [6345: 4-trifluoromethyl-2-methoxyphenyl], [6346 : 5-trifluoromethyl-2-methoxyphenyl], [6347: 6-trifluoromethyl-2-methoxyphenyl], [6348: 3-methylthio-2-methoxyphenyl], [6349: 4-methylthio-2- Methoxyphenyl], [6350: 5-methylthio-2-methoxyphenyl], [6351: 6-methylthio-2-methoxyphenyl], [6352: 3-trifluoromethylthio-2-methoxyphenyl], [6353: 4- Trifluoromethylthio-2-methoxyphenyl], [6354: 5 Trifluoromethylthio-2-methoxyphenyl], [6355: 6-trifluoromethylthio-2-methoxyphenyl], [6356: 3-ethynyl-2-methoxyphenyl], [6357: 4-ethynyl-2-methoxyphenyl] [6358: 5-ethynyl-2-methoxyphenyl], [6359: 6-ethynyl-2-methoxyphenyl], [6360: 3-cyclopropyl-2-methoxyphenyl], [6361: 4-cyclopropyl-2] -Methoxyphenyl], [6362: 5-cyclopropyl-2-methoxyphenyl], [6363: 6-cyclopropyl-2-methoxyphenyl], [6364: 3-cyclopropyloxy-2-methoxyphenyl], [6365 : 4-cyclopropyloxy-2-methoxyphenyl], [63 66: 5-cyclopropyloxy-2-methoxyphenyl], [6367: 6-cyclopropyloxy-2-methoxyphenyl], [6368: 2-ethoxy-3-fluorophenyl], [6369: 2-ethoxy-4. -Fluorophenyl], [6370: 2-ethoxy-5-fluorophenyl], [6331: 2-ethoxy-6-fluorophenyl], [6372: 3-chloro-2-ethoxyphenyl], [6373: 4-chloro. -2-ethoxyphenyl], [6374: 5-chloro-2-ethoxyphenyl], [6375: 6-chloro-2-ethoxyphenyl], [6376: 3-bromo-2-ethoxyphenyl], [6377: 4 -Bromo-2-ethoxyphenyl], [6378: 5-Bromo-2-ethoxyphenyl], [6379: -Bromo-2-ethoxyphenyl], [6380: 2-ethoxy-3-iodophenyl], [6381: 2-ethoxy-4-iodophenyl], [6382: 2-ethoxy-5-iodophenyl], [6383 : 2-ethoxy-6-iodophenyl], [6384: 2,3-diethoxyphenyl], [6385: 2,4-diethoxyphenyl], [6386: 2,5-diethoxyphenyl], [6387: 2,6-diethoxyphenyl], [6388: 2-ethoxy-3-methylphenyl], [6389: 2-ethoxy-4-methylphenyl], [6390: 2-ethoxy-5-methylphenyl], [6381 : 2-ethoxy-6-methylphenyl], [6392: 3-ethyl-2-ethoxyphenyl], [6393: 4-ethyl-2-ethyl Xiphenyl], [6394: 5-ethyl-2-ethoxyphenyl], [6395: 6-ethyl-2-ethoxyphenyl], [6396: 2-ethoxy-3-trifluoromethoxyphenyl], [6397: 2-ethoxy -4-trifluoromethoxyphenyl], [6398: 2-ethoxy-5-trifluoromethoxyphenyl], [6399: 2-ethoxy-6-trifluoromethoxyphenyl], [6400: 2-ethoxy-3-trifluoro. Methylphenyl],

[6401: 2-ethoxy-4-trifluoromethylphenyl], [6402: 2-ethoxy-5-trifluoromethylphenyl], [6403: 2-ethoxy-6-trifluoromethylphenyl], [6404: 2- Ethoxy-3-methylthiophenyl], [6405: 2-ethoxy-4-methylthiophenyl], [6406: 2-ethoxy-5-methylthiophenyl], [6407: 2-ethoxy-6-methylthiophenyl], [6408: 2-ethoxy-3-trifluoromethylthiophenyl], [6409: 2-ethoxy-4-trifluoromethylthiophenyl], [6410: 2-ethoxy-5-trifluoromethylthiophenyl], [6411: 2-ethoxy-6 -Trifluoromethylthiophenyl], [6412: 3-ethini -2-ethoxyphenyl], [6413: 4-ethynyl-2-ethoxyphenyl], [6414: 5-ethynyl-2-ethoxyphenyl], [6415: 6-ethynyl-2-ethoxyphenyl], [6416: 3 -Cyclopropyl-2-ethoxyphenyl], [6417: 4-cyclopropyl-2-ethoxyphenyl], [6418: 5-cyclopropyl-2-ethoxyphenyl], [6419: 6-cyclopropyl-2-ethoxyphenyl] ], [6420: 3-cyclopropyloxy-2-ethoxyphenyl], [6421: 4-cyclopropyloxy-2-ethoxyphenyl], [6422: 5-cyclopropyloxy-2-ethoxyphenyl], [6423: 6-cyclopropyloxy-2-ethoxyphenyl], [6424: 3- Toxi-2-methylphenyl], [6425: 4-methoxy-2-methylphenyl], [6426: 5-methoxy-2-methylphenyl], [6427: 6-methoxy-2-methylphenyl], [6428: 3-ethoxy-2-methylphenyl], [6429: 4-ethoxy-2-methylphenyl], [6430: 5-ethoxy-2-methylphenyl], [6431: 6-ethoxy-2-methylphenyl], [ 6432: 3-ethyl-2-methylphenyl], [6433: 4-ethyl-2-methylphenyl], [6434: 5-ethyl-2-methylphenyl], [6435: 6-ethyl-2-methylphenyl] [6436: 3-trifluoromethoxy-2-methylphenyl], [6437: 4-trifluoromethoxy-2-methylphenyl] ], [6438: 5-trifluoromethoxy-2-methylphenyl], [6439: 6-trifluoromethoxy-2-methylphenyl], [6440: 3-trifluoromethyl-2-methylphenyl], [6441: 4-trifluoromethyl-2-methylphenyl], [6442: 5-trifluoromethyl-2-methylphenyl], [6443: 6-trifluoromethyl-2-methylphenyl], [6444: 3-methylthio-2 -Methylphenyl], [6445: 4-methylthio-2-methylphenyl], [6446: 5-methylthio-2-methylphenyl], [6447: 6-methylthio-2-methylphenyl], [6448: 4-fluoro. -2-isopropyloxyphenyl], [6449: 4-chloro-2-isopropyloxyphene [6450: 4-bromo-2-isopropyloxyphenyl], [6451: 4-iodo-2-isopropyloxyphenyl], [6452: 4-methyl-2-isopropyloxyphenyl], [6453: 4- Ethyl-2-isopropyloxyphenyl], [6454: 4-methoxy-2-isopropyloxyphenyl], [6455: 4-ethoxy-2-isopropyloxyphenyl], [6456: 4-trifluoromethyl-2-isopropyloxy. Phenyl], [6457: 4-trifluoromethoxy-2-isopropyloxyphenyl], [6458: 4-methylthio-2-isopropyloxyphenyl], [6459: 4-cyclopropyl-2-isopropyloxyphenyl], [6460 : 4-Fluoro-2-cyclo [Ropyloxyphenyl], [6461: 4-chloro-2-cyclopropyloxyphenyl], [6462: 4-bromo-2-cyclopropyloxyphenyl], [6463: 4-iodo-2-cyclopropyloxyphenyl] [6464: 4-methyl-2-cyclopropyloxyphenyl], [6465: 4-ethyl-2-cyclopropyloxyphenyl], [6466: 4-methoxy-2-cyclopropyloxyphenyl], [6467: 4. -Ethoxy-2-cyclopropyloxyphenyl], [6468: 4-trifluoromethyl-2-cyclopropyloxyphenyl], [6469: 4-trifluoromethoxy-2-cyclopropyloxyphenyl], [6470: 4- Methylthio-2-cyclopropyloxyphenyl], [647 1: 4-cyclopropyl-2-cyclopropyloxyphenyl], [6472: 3,4-difluoro-2-methoxyphenyl], [6473: 4,5-difluoro-2-methoxyphenyl], [6474: 4 6-difluoro-2-methoxyphenyl], [6475: 3,4,5-trifluoro-2-methoxyphenyl], [6476: 3,4,5,6-tetrafluoro-2-methoxyphenyl], [6477 : 4-chloro-3-fluoro-2-methoxyphenyl], [6478: 4-chloro-5-fluoro-2-methoxyphenyl], [6479: 4-chloro-6-fluoro-2-methoxyphenyl], [ 6480: 4-bromo-3-fluoro-2-methoxyphenyl], [6481: 4-bromo-5-fluoro-2-methoxyphenyl] [6482: 4-Bromo-6-fluoro-2-methoxyphenyl], [6483: 3,4-difluoro-2-ethoxyphenyl], [6484: 4,5-difluoro-2-ethoxyphenyl], [6485: 4,6-difluoro-2-ethoxyphenyl], [6486: 3,4,5-trifluoro-2-ethoxyphenyl], [6487: 3,4,5,6-tetrafluoro-2-ethoxyphenyl], [6488: 4-chloro-3-fluoro-2-ethoxyphenyl], [6489: 4-chloro-5-fluoro-2-ethoxyphenyl], [6490: 4-chloro-6-fluoro-2-ethoxyphenyl] [6491: 4-Bromo-3-fluoro-2-ethoxyphenyl], [6492: 4-Bromo-5-fluoro-2-ethoxypheny]. ], [6493: 4-Bromo-6-fluoro-2-ethoxyphenyl], [6494: 3,4-difluoro-2-isopropyloxyphenyl], [6495: 4,5-difluoro-2-isopropyloxyphenyl] [6496: 4,6-difluoro-2-isopropyloxyphenyl], [6497: 3,4,5-trifluoro-2-isopropyloxyphenyl], [6498: 3,4,5,6-tetrafluoro- 2-isopropyloxyphenyl], [6499: 4-chloro-3-fluoro-2-isopropyloxyphenyl], [6500: 4-chloro-5-fluoro-2-isopropyloxyphenyl],

[6501: 4-Chloro-6-fluoro-2-isopropyloxyphenyl], [6502: 4-Bromo-3-fluoro-2-isopropyloxyphenyl], [6503: 4-Bromo-5-fluoro-2-isopropyl Oxyphenyl], [6504: 4-bromo-6-fluoro-2-isopropyloxyphenyl], [6505: 3,4-difluoro-2-cyclopropyloxyphenyl], [6506: 4,5-difluoro-2- Cyclopropyloxyphenyl], [6507: 4,6-difluoro-2-cyclopropyloxyphenyl], [6508: 3,4,5-trifluoro-2-cyclopropyloxyphenyl], [6509: 3,4, 5,6-tetrafluoro-2-cyclopropyloxyphenyl], [6510: 4-chloro -3-fluoro-2-cyclopropyloxyphenyl], [6511: 4-chloro-5-fluoro-2-cyclopropyloxyphenyl], [6512: 4-chloro-6-fluoro-2-cyclopropyloxyphenyl] ], [6513: 4-Bromo-3-fluoro-2-cyclopropyloxyphenyl], [6514: 4-Bromo-5-fluoro-2-cyclopropyloxyphenyl], [6515: 4-Bromo-6- Fluoro-2-cyclopropyloxyphenyl], [6516: 3-ethynyl-2-methylphenyl], [6517: 4-ethynyl-2-methylphenyl], [6518: 5-ethynyl-2-methylphenyl], [ 6519: 6-ethynyl-2-methylphenyl], [6520: 3-cyclopropyl-2-methylphen [6521: 4-cyclopropyl-2-methylphenyl], [6522: 5-cyclopropyl-2-methylphenyl], [6523: 6-cyclopropyl-2-methylphenyl], [6524: 3- Cyclopropyloxy-2-methylphenyl], [6525: 4-cyclopropyloxy-2-methylphenyl], [6526: 5-cyclopropyloxy-2-methylphenyl], [6527: 6-cyclopropyloxy-2] -Methylphenyl], [6528: 3-methoxy-2-fluorophenyl], [6529: 4-methoxy-2-fluorophenyl], [6530: 5-methoxy-2-fluorophenyl], [6531: 6-methoxy -2-fluorophenyl], [6532: 3-ethoxy-2-fluorophenyl], [653 3: 4-ethoxy-2-fluorophenyl], [6534: 5-ethoxy-2-fluorophenyl], [6535: 6-ethoxy-2-fluorophenyl], [6536: 3-ethyl-2-fluorophenyl] , [6537: 5-ethyl-2-fluorophenyl], [6538: 6-ethyl-2-fluorophenyl], [6539: 2-fluoro-3-trifluoromethoxyphenyl], [6540: 2-fluoro-4 -Trifluoromethoxyphenyl], [6541: 2-fluoro-5-trifluoromethoxyphenyl], [6542: 2-fluoro-6-trifluoromethoxyphenyl], [6543: 2-fluoro-3-trifluoromethylphenyl] ], [6544: 2-Fluoro-4-trifluoromethylphenyl], [6545: -Fluoro-5-trifluoromethylphenyl], [6546: 2-fluoro-6-trifluoromethylphenyl], [6547: 2-fluoro-3-fluorothiophenyl], [6548: 2-fluoro-4-fluoro. Thiophenyl], [6549: 2-fluoro-5-fluorothiophenyl], [6550: 2-fluoro-6-fluorothiophenyl], [6551: 3-ethynyl-2-fluorophenyl], [6552: 4- [Ethynyl-2-fluorophenyl], [6553: 5-ethynyl-2-fluorophenyl], [6554: 6-ethynyl-2-fluorophenyl], [6555: 3-cyclopropyl-2-fluorophenyl], [6556] : 4-cyclopropyl-2-fluorophenyl], [6557: 5-cyclopropyl. 2-fluorophenyl], [6558: 6-cyclopropyl-2-fluorophenyl], [6559: 3-cyclopropyloxy-2-fluorophenyl], [6560: 4-cyclopropyloxy-2-fluorophenyl], [6561: 5-cyclopropyloxy-2-fluorophenyl], [6562: 6-cyclopropyloxy-2-fluorophenyl], [6563: 2-ethyl-3-fluorophenyl], [6564: 2-ethyl- 4-fluorophenyl], [6565: 2-ethyl-5-fluorophenyl], [6566: 2-ethyl-6-fluorophenyl], [6567: 3-chloro-2-ethylphenyl], [6568: 4- Chloro-2-ethylphenyl], [6569: 5-chloro-2-ethylphenyl], [657 0: 6-chloro-2-ethylphenyl], [6571: 3-bromo-2-ethylphenyl], [6572: 4-bromo-2-ethylphenyl], [6573: 5-bromo-2-ethylphenyl] [6574: 6-bromo-2-ethylphenyl], [6575: 2-ethyl-3-iodophenyl], [6576: 2-ethyl-4-iodophenyl], [6577: 2-ethyl-5-iodo. Phenyl], [6578: 2-ethyl-6-iodophenyl], [6579: 2-ethyl-3-ethoxyphenyl], [6580: 2-ethyl-4-ethoxyphenyl], [6581: 2-ethyl-5 -Ethoxyphenyl], [6582: 2-ethyl-6-ethoxyphenyl], [6583: 2-ethyl-3-methylphenyl], [6584: 2-ethyl. 4-methylphenyl], [6585: 2-ethyl-5-methylphenyl], [6586: 2-ethyl-6-methylphenyl], [6587: 2,3-diethylphenyl], [6588: 2,4- Diethylphenyl], [6589: 2,5-diethylphenyl], [6590: 2,6-diethylphenyl], [6591: 2-ethyl-3-trifluoromethoxyphenyl], [6592: 2-ethyl-4- Trifluoromethoxyphenyl], [6593: 2-ethyl-5-trifluoromethoxyphenyl], [6594: 2-ethyl-6-trifluoromethoxyphenyl], [6595: 2-ethyl-3-trifluoromethylphenyl]. [6596: 2-ethyl-4-trifluoromethylphenyl], [6597: 2-ethyl-5-trifluoro. Oro-methylphenyl], [6598: 2-ethyl-6-trifluoromethyl-phenyl], [6599: 2-ethyl-3-methylthiophenyl], [6600: 2-ethyl-4-methylthiophenyl,

[6601: 2-ethyl-5-methylthiophenyl], [6602: 2-ethyl-6-methylthiophenyl], [6603: 2-ethyl-3-trifluoromethylthiophenyl], [6604: 2-ethyl-4- Trifluoromethylthiophenyl], [6605: 2-ethyl-5-trifluoromethylthiophenyl], [6606: 2-ethyl-6-trifluoromethylthiophenyl], [6607: 3-ethynyl-2-ethylphenyl], [ 6608: 4-ethynyl-2-ethylphenyl], [6609: 5-ethynyl-2-ethylphenyl], [6610: 6-ethynyl-2-ethylphenyl], [6611: 3-cyclopropyl-2-ethylphenyl] ], [6612: 4-Cyclopropyl-2-ethylphenyl], [6613: 5-Si Ropropyl-2-ethylphenyl], [6614: 6-cyclopropyl-2-ethylphenyl], [6615: 3-cyclopropyloxy-2-ethylphenyl], [6616: 4-cyclopropyloxy-2-ethylphenyl] ], [6617: 5-cyclopropyloxy-2-ethylphenyl], [6618: 6-cyclopropyloxy-2-ethylphenyl], [6619: 3-fluoro-2-trifluoromethylphenyl], [6620: 4-fluoro-2-trifluoromethylphenyl], [6621: 5-fluoro-2-trifluoromethylphenyl], [6622: 6-fluoro-2-trifluoromethylphenyl], [6623: 3-chloro-2 -Trifluoromethylphenyl], [6624: 4-chloro-2-trifluoro Methylphenyl], [6625: 5-chloro-2-trifluoromethylphenyl], [6626: 6-chloro-2-trifluoromethylphenyl], [6627: 3-bromo-2-trifluoromethylphenyl], [ 6628: 4-bromo-2-trifluoromethylphenyl], [6629: 5-bromo-2-trifluoromethylphenyl], [6630: 6-bromo-2-trifluoromethylphenyl], [6631: 3-iodo -2-trifluoromethylphenyl], [6632: 4-iodo-2-trifluoromethylphenyl], [6633: 5-iodo-2-trifluoromethylphenyl], [6634: 6-iodo-2-trifluoro Methylphenyl], [6635: 3-ethoxy-2-trifluoromethylphenyl], [663 6: 4-Ethoxy-2-trifluoromethylphenyl], [6637: 5-Ethoxy-2-trifluoromethylphenyl], [6638: 6-Ethoxy-2-trifluoromethylphenyl], [6639: 3-Methyl -2-trifluoromethylphenyl], [6640: 4-methyl-2-trifluoromethylphenyl], [6641: 5-methyl-2-trifluoromethylphenyl], [6642: 6-methyl-2-trifluoro Methylphenyl], [6643: 2,3-ditrifluoromethylphenyl], [6644: 2,4-ditrifluoromethylphenyl], [6665: 2,5-ditrifluoromethylphenyl], [6646: 2,6- Ditrifluoromethylphenyl], [6647: 2-trifluoromethyl-3-trifluorome Xiphenyl], [6648: 2-trifluoromethyl-4-trifluoromethoxyphenyl], [6649: 2-trifluoromethyl-5-trifluoromethoxyphenyl], [6650: 2-trifluoromethyl-6-trifluoro Methoxyphenyl], [6651: 2-ethyl-3-trifluoromethylphenyl], [6652: 2-ethyl-4-trifluoromethylphenyl], [6653: 2-ethyl-5-trifluoromethylphenyl], [ 6654: 2-ethyl-6-trifluoromethylphenyl], [6655: 3-methylthio-2-trifluoromethylphenyl], [6656: 4-methylthio-2-trifluoromethylphenyl], [6657: 5-methylthio -2-trifluoromethylphenyl], [6658: 6 Methylthio-2-trifluoromethylphenyl], [6659: 2-trifluoromethyl-3-trifluoromethylthiophenyl], [6660: 2-trifluoromethyl-4-trifluoromethylthiophenyl], [6661: 2-tri Fluoromethyl-5-trifluoromethylthiophenyl], [6662: 2-trifluoromethyl-6-trifluoromethylthiophenyl], [6663: 3-ethynyl-2-trifluoromethylphenyl], [6664: 4-ethynyl- 2-trifluoromethylphenyl], [6665: 5-ethynyl-2-trifluoromethylphenyl], [6666: 6-ethynyl-2-trifluoromethylphenyl], [6667: 3-cyclopropyl-2-trifluoro Methylphenyl], [6668: 4-si Chloropropyl-2-trifluoromethylphenyl], [6669: 5-cyclopropyl-2-trifluoromethylphenyl], [6670: 6-cyclopropyl-2-trifluoromethylphenyl], [6671: 3-cyclopropyl Oxy-2-trifluoromethylphenyl], [6672: 4-cyclopropyloxy-2-trifluoromethylphenyl], [6673: 5-cyclopropyloxy-2-trifluoromethylphenyl], [6674: 6-cyclo Propyloxy-2-trifluoromethylphenyl], [6675: 3-methoxynaphthalen-2-yl], [6676: 6-chloro-3-methoxynaphthalen-2-yl], [6677: 6-fluoro-3- Methoxynaphthalen-2-yl], [6678: 7-chloro-3- Toxinaphthalen-2-yl], [6679: 7-fluoro-3-methoxynaphthalen-2-yl], [6680: 8-chloro-3-methoxynaphthalen-2-yl], [6681: 8-fluoro-3 -Methoxynaphthalen-2-yl], [6682: 1-chloro-3-methoxynaphthalen-2-yl], [6683: 1-fluoro-3-methoxynaphthalen-2-yl], [6684: 4-chloro- 3-methoxynaphthalen-2-yl], [6685: 4-fluoro-3-methoxynaphthalen-2-yl], [6686: 5-chloro-3-methoxynaphthalen-2-yl], [6687: 5-fluoro -3-methoxynaphthalen-2-yl], [6688: 1-naphthyl], [6689: 2-naphthyl], [6690: adamantane-1 Yl], [6691: 3-methyladamantan-1-yl], [6692: 5-methyladamantan-1-yl], [6693: 5,7-dimethyladamantan-1-yl], [6694: 3,5 -Dimethyladamantan-1-yl], [6695: 3,5,7-trimethyladamantan-1-yl], [6696: 5-methyladamantan-1-yl], [6697: 5,7-dimethyladamantane-1 -Yl], [6698: 3,5-dimethyladamantan-1-yl], [6699: 3,5,7-trimethyladamantan-1-yl], [6700: PYR1],

[6701: 3-Me-PYR1], [6702: 3-Me-4-F-PYR1], [6703: 3-Me-4-Cl-PYR1], [6704: 3-Me-4-Br-PYR1] ], [6705: 3-Me-4-Me-PYR1], [6706: 3-Me-4-Et-PYR1], [6707: 3-Me-4-OMe-PYR1], [6708: 3-Me. -4-OEt-PYR1], [6709: 3-Me-4-CN-PYR1], [6710: 3-Me-4-c-Pr-PYR1], [6711: 3-Me-4-CHF2-PYR1] ], [6712: 3-Me-4-CF3-PYR1], [6713: 3-Me-5-F-PYR1], [6714: 3-Me-4-F-5-F-PYR1], [6715]. : 3-Me-4-Cl-5-F-PY 1], [6716: 3-Me-4-Br-5-F-PYR1], [6717: 3-Me-4-Me-5-F-PYR1], [6718: 3-Me-4-Et- 5-F-PYR1], [6719: 3-Me-4-OMe-5-F-PYR1], [6720: 3-Me-4-OEt-5-F-PYR1], [6721: 3-Me- 4-CN-5-F-PYR1], [6722: 3-Me-4-c-Pr-5-F-PYR1], [6723: 3-Me-4-CHF2-5-F-PYR1], [ 6724: 3-Me-4-CF3-5-F-PYR1], [6725: 3-Me-5-Cl-PYR1], [6726: 3-Me-4-F-5-Cl-PYR1], [ 6727: 3-Me-4-Cl-5-Cl-PYR1], [6728: 3-Me-4- r-5-Cl-PYR1], [6729: 3-Me-4-Me-5-Cl-PYR1], [6730: 3-Me-4-Et-5-Cl-PYR1], [6731: 3- Me-4-OMe-5-Cl-PYR1], [6732: 3-Me-4-OEt-5-Cl-PYR1], [6733: 3-Me-4-CN-5-Cl-PYR1], [ 6734: 3-Me-4-c-Pr-5-Cl-PYR1], [6735: 3-Me-4-CHF2-5-Cl-PYR1], [6736: 3-Me-4-CF3-5 Cl-PYR1], [6737: 3-Me-5-Br-PYR1], [6738: 3-Me-4-F-5-Br-PYR1], [6739: 3-Me-4-Cl-5 Br-PYR1], [6740: 3-Me-4-Br-5-Br-P YR1], [6741: 3-Me-4-Me-5-Br-PYR1], [6742: 3-Me-4-Et-5-Br-PYR1], [6743: 3-Me-4-OMe- 5-Br-PYR1], [6744: 3-Me-4-OEt-5-Br-PYR1], [6745: 3-Me-4-CN-5-Br-PYR1], [6746: 3-Me- 4-c-Pr-5-Br-PYR1], [6747: 3-Me-4-CHF2-5-Br-PYR1], [6748: 3-Me-4-CF3-5-Br-PYR1], [ 6749: 3-Me-5-Me-PYR1], [6750: 3-Me-4-F-5-Me-PYR1], [6751: 3-Me-4-Cl-5-Me-PYR1], [ 6752: 3-Me-4-Br-5-Me-PYR1], [67 3: 3-Me-4-Me-5-Me-PYR1], [6754: 3-Me-4-Et-5-Me-PYR1], [6755: 3-Me-4-OMe-5-Me- PYR1], [6756: 3-Me-4-OEt-5-Me-PYR1], [6757: 3-Me-4-CN-5-Me-PYR1], [6758: 3-Me-4-c- Pr-5-Me-PYR1], [6759: 3-Me-4-CHF2-5-Me-PYR1], [6760: 3-Me-4-CF3-5-Me-PYR1], [6761: 3- Me-5-Et-PYR1], [6762: 3-Me-4-F-5-Et-PYR1], [6763: 3-Me-4-Cl-5-Et-PYR1], [6764: 3- Me-4-Br-5-Et-PYR1], [6765: 3-Me- -Me-5-Et-PYR1], [6766: 3-Me-4-Et-5-Et-PYR1], [6767: 3-Me-4-OMe-5-Et-PYR1], [6768: 3. -Me-4-OEt-5-Et-PYR1], [6769: 3-Me-4-CN-5-Et-PYR1], [6770: 3-Me-4-c-Pr-5-Et-PYR1] ], [6711: 3-Me-4-CHF2-5-Et-PYR1], [6772: 3-Me-4-CF3-5-Et-PYR1], [6773: 3-Me-5-OMe-PYR1] ], [6774: 3-Me-4-F-5-OMe-PYR1], [6775: 3-Me-4-Cl-5-OMe-PYR1], [6776: 3-Me-4-Br-5]. -OMe-PYR1], [6777: 3-Me-4-Me- 5-OMe-PYR1], [6778: 3-Me-4-Et-5-OMe-PYR1], [6779: 3-Me-4-OMe-5-OMe-PYR1], [6780: 3-Me- 4-OEt-5-OMe-PYR1], [6781: 3-Me-4-CN-5-OMe-PYR1], [6782: 3-Me-4-c-Pr-5-OMe-PYR1], [ 6783: 3-Me-4-CHF2-5-OMe-PYR1], [6784: 3-Me-4-CF3-5-OMe-PYR1], [6785: 3-Me-5-OEt-PYR1], [ 6786: 3-Me-4-F-5-OEt-PYR1], [6787: 3-Me-4-Cl-5-OEt-PYR1], [6788: 3-Me-4-Br-5-OEt- PYR1], [6789: 3-Me-4 Me-5-OEt-PYR1], [6790: 3-Me-4-Et-5-OEt-PYR1], [6791: 3-Me-4-OMe-5-OEt-PYR1], [6792: 3- Me-4-OEt-5-OEt-PYR1], [6793: 3-Me-4-CN-5-OEt-PYR1], [6794: 3-Me-4-c-Pr-5-OEt-PYR1] [6795: 3-Me-4-CHF2-5-OEt-PYR1], [6796: 3-Me-4-CF3-5-OEt-PYR1], [6797: 3-Me-5-CN-PYR1] [6798: 3-Me-4-F-5-CN-PYR1], [6799: 3-Me-4-Cl-5-CN-PYR1], [6800: 3-Me-4-Br-5-5]. CN-PYR1],

[6801: 3-Me-4-Me-5-CN-PYR1], [6802: 3-Me-4-Et-5-CN-PYR1], [6803: 3-Me-4-OMe-5-CN -PYR1], [6804: 3-Me-4-OEt-5-CN-PYR1], [6805: 3-Me-4-CN-5-CN-PYR1], [6806: 3-Me-4-c -Pr-5-CN-PYR1], [6807: 3-Me-4-CHF2-5-CN-PYR1], [6808: 3-Me-4-CF3-5-CN-PYR1], [6809: 3 -Me-5-c-Pr-PYR1], [6810: 3-Me-4-F-5-c-Pr-PYR1], [6811: 3-Me-4-Cl-5-c-Pr-PYR1] ], [6812: 3-Me-4-Br-5-c-Pr-PYR1], 6813: 3-Me-4-Me-5-c-Pr-PYR1], [6814: 3-Me-4-Et-5-c-Pr-PYR1], [6815: 3-Me-4-OMe- 5-c-Pr-PYR1], [6816: 3-Me-4-OEt-5-c-Pr-PYR1], [6817: 3-Me-4-CN-5-c-Pr-PYR1], [ 6818: 3-Me-4-c-Pr-5-c-Pr-PYR1], [6819: 3-Me-4-CHF2-5-c-Pr-PYR1], [6820: 3-Me-4- CF3-5-c-Pr-PYR1], [6821: 3-Me-5-CHF2-PYR1], [6822: 3-Me-4-F-5-CHF2-PYR1], [6823: 3-Me- 4-Cl-5-CHF2-PYR1], [6824: 3-Me-4- r-5-CHF2-PYR1], [6825: 3-Me-4-Me-5-CHF2-PYR1], [6826: 3-Me-4-Et-5-CHF2-PYR1], [6827: 3- Me-4-OMe-5-CHF2-PYR1], [6828: 3-Me-4-OEt-5-CHF2-PYR1], [6829: 3-Me-4-CN-5-CHF2-PYR1], [ 6830: 3-Me-4-c-Pr-5-CHF2-PYR1], [6831: 3-Me-4-CHF2-5-CHF2-PYR1], [6832: 3-Me-4-CF3-5 CHF2-PYR1], [6833: 3-Me-5-CF3-PYR1], [6834: 3-Me-4-F-5-CF3-PYR1], [6835: 3-Me-4-Cl-5] CF3-PYR1], [ 6836: 3-Me-4-Br-5-CF3-PYR1], [6837: 3-Me-4-Me-5-CF3-PYR1], [6838: 3-Me-4-Et-5-CF3- PYR1], [6839: 3-Me-4-OMe-5-CF3-PYR1], [6840: 3-Me-4-OEt-5-CF3-PYR1], [6841: 3-Me-4-CN- 5-CF3-PYR1], [6842: 3-Me-4-c-Pr-5-CF3-PYR1], [6843: 3-Me-4-CHF2-5-CF3-PYR1], [6844: 3- Me-4-CF3-5-CF3-PYR1], [6845: 3-Et-PYR1], [6846: 3-Et-4-F-PYR1], [6847: 3-Et-4-Cl-PYR1] [6848: 3-Et-4-Br PYR1], [6849: 3-Et-4-Me-PYR1], [6850: 3-Et-4-Et-PYR1], [6851: 3-Et-4-OMe-PYR1], [6852: 3- Et-4-OEt-PYR1], [6853: 3-Et-4-CN-PYR1], [6854: 3-Et-4-c-Pr-PYR1], [6855: 3-Et-4-CHF2- PYR1], [6856: 3-Et-4-CF3-PYR1], [6857: 3-Et-5-F-PYR1], [6858: 3-Et-4-F-5-F-PYR1], [ 6859: 3-Et-4-Cl-5-F-PYR1], [6860: 3-Et-4-Br-5-F-PYR1], [6861: 3-Et-4-Me-5-F- PYR1], [6862: 3-Et-4-Et-5-F PYR1], [6863: 3-Et-4-OMe-5-F-PYR1], [6864: 3-Et-4-OEt-5-F-PYR1], [6865: 3-Et-4-CN- 5-F-PYR1], [6866: 3-Et-4-c-Pr-5-F-PYR1], [6867: 3-Et-4-CHF2-5-F-PYR1], [6868: 3- Et-4-CF3-5-F-PYR1], [6869: 3-Et-5-Cl-PYR1], [6870: 3-Et-4-F-5-Cl-PYR1], [6871: 3- Et-4-Cl-5-Cl-PYR1], [6872: 3-Et-4-Br-5-Cl-PYR1], [6873: 3-Et-4-Me-5-Cl-PYR1], [ 6874: 3-Et-4-Et-5-Cl-PYR1], [6875: 3- Et-4-OMe-5-Cl-PYR1], [6876: 3-Et-4-OEt-5-Cl-PYR1], [6877: 3-Et-4-CN-5-Cl-PYR1], [ 6878: 3-Et-4-c-Pr-5-Cl-PYR1], [6879: 3-Et-4-CHF2-5-Cl-PYR1], [6880: 3-Et-4-CF3-5 Cl-PYR1], [6881: 3-Et-5-Br-PYR1], [6882: 3-Et-4-F-5-Br-PYR1], [6883: 3-Et-4-Cl-5-5 Br-PYR1], [6884: 3-Et-4-Br-5-Br-PYR1], [6885: 3-Et-4-Me-5-Br-PYR1], [6886: 3-Et-4- Et-5-Br-PYR1], [6887: 3-Et-4-OMe 5-Br-PYR1], [6888: 3-Et-4-OEt-5-Br-PYR1], [6889: 3-Et-4-CN-5-Br-PYR1], [6890: 3-Et- 4-c-Pr-5-Br-PYR1], [6891: 3-Et-4-CHF2-5-Br-PYR1], [6882: 3-Et-4-CF3-5-Br-PYR1], [ 6893: 3-Et-5-Me-PYR1], [6894: 3-Et-4-F-5-Me-PYR1], [6895: 3-Et-4-Cl-5-Me-PYR1], [ 6896: 3-Et-4-Br-5-Me-PYR1], [6897: 3-Et-4-Me-5-Me-PYR1], [6898: 3-Et-4-Et-5-Me- PYR1], [6899: 3-Et-4-OMe-5-Me-PY 1], [6900: 3-Et-4-OEt-5-Me-PYR1],

[6901: 3-Et-4-CN-5-Me-PYR1], [6902: 3-Et-4-c-Pr-5-Me-PYR1], [6903: 3-Et-4-CHF2-5 -Me-PYR1], [6904: 3-Et-4-CF3-5-Me-PYR1], [6905: 3-Et-5-Et-PYR1], [6906: 3-Et-4-F-5 -Et-PYR1], [6907: 3-Et-4-Cl-5-Et-PYR1], [6908: 3-Et-4-Br-5-Et-PYR1], [6909: 3-Et-4 -Me-5-Et-PYR1], [6910: 3-Et-4-Et-5-Et-PYR1], [6911: 3-Et-4-OMe-5-Et-PYR1], [6912: 3 -Et-4-OEt-5-Et-PYR1], [6913: 3- t-4-CN-5-Et-PYR1], [6914: 3-Et-4-c-Pr-5-Et-PYR1], [6915: 3-Et-4-CHF2-5-Et-PYR1] [6916: 3-Et-4-CF3-5-Et-PYR1], [6917: 3-Et-5-OMe-PYR1], [6918: 3-Et-4-F-5-OMe-PYR1] [6919: 3-Et-4-Cl-5-OMe-PYR1], [6920: 3-Et-4-Br-5-OMe-PYR1], [6921: 3-Et-4-Me-5- OMe-PYR1], [6922: 3-Et-4-Et-5-OMe-PYR1], [6923: 3-Et-4-OMe-5-OMe-PYR1], [6924: 3-Et-4- OEt-5-OMe-PYR1], [6925: 3- t-4-CN-5-OMe-PYR1], [6926: 3-Et-4-c-Pr-5-OMe-PYR1], [6927: 3-Et-4-CHF2-5-OMe-PYR1] [6928: 3-Et-4-CF3-5-OMe-PYR1], [6929: 3-Et-5-OEt-PYR1], [6930: 3-Et-4-F-5-OEt-PYR1] [6931: 3-Et-4-Cl-5-OEt-PYR1], [6932: 3-Et-4-Br-5-OEt-PYR1], [6933: 3-Et-4-Me-5 OEt-PYR1], [6934: 3-Et-4-Et-5-OEt-PYR1], [6935: 3-Et-4-OMe-5-OEt-PYR1], [6936: 3-Et-4- OEt-5-OEt-PYR1], [6937 : 3-Et-4-CN-5-OEt-PYR1], [6938: 3-Et-4-c-Pr-5-OEt-PYR1], [6939: 3-Et-4-CHF2-5-OEt -PYR1], [6940: 3-Et-4-CF3-5-OEt-PYR1], [6941: 3-Et-5-CN-PYR1], [6942: 3-Et-4-F-5-CN -PYR1], [6943: 3-Et-4-Cl-5-CN-PYR1], [6944: 3-Et-4-Br-5-CN-PYR1], [6945: 3-Et-4-Me. -5-CN-PYR1], [6946: 3-Et-4-Et-5-CN-PYR1], [6947: 3-Et-4-OMe-5-CN-PYR1], [6948: 3-Et -4-OEt-5-CN-PYR1], [6949: 3-E -4-CN-5-CN-PYR1], [6950: 3-Et-4-c-Pr-5-CN-PYR1], [6951: 3-Et-4-CHF2-5-CN-PYR1], [6952: 3-Et-4-CF3-5-CN-PYR1], [6953: 3-Et-5-c-Pr-PYR1], [6954: 3-Et-4-F-5-c-Pr -PYR1], [6955: 3-Et-4-Cl-5-c-Pr-PYR1], [6956: 3-Et-4-Br-5-c-Pr-PYR1], [6957: 3-Et -4-Me-5-c-Pr-PYR1], [6958: 3-Et-4-Et-5-c-Pr-PYR1], [6959: 3-Et-4-OMe-5-c-Pr -PYR1], [6960: 3-Et-4-OEt-5-c-Pr-PYR1], [ 961: 3-Et-4-CN-5-c-Pr-PYR1], [6962: 3-Et-4-c-Pr-5-c-Pr-PYR1], [6963: 3-Et-4- CHF2-5-c-Pr-PYR1], [6964: 3-Et-4-CF3-5-c-Pr-PYR1], [6965: 3-Et-5-CHF2-PYR1], [6966: 3- Et-4-F-5-CHF2-PYR1], [6967: 3-Et-4-Cl-5-CHF2-PYR1], [6968: 3-Et-4-Br-5-CHF2-PYR1], [ 6969: 3-Et-4-Me-5-CHF2-PYR1], [6970: 3-Et-4-Et-5-CHF2-PYR1], [6791: 3-Et-4-OMe-5-CHF2- PYR1], [6792: 3-Et-4-OEt -5-CHF2-PYR1], [6793: 3-Et-4-CN-5-CHF2-PYR1], [6974: 3-Et-4-c-Pr-5-CHF2-PYR1], [6975: 3 -Et-4-CHF2-5-CHF2-PYR1], [6976: 3-Et-4-CF3-5-CHF2-PYR1], [6977: 3-Et-5-CF3-PYR1], [6978: 3 -Et-4-F-5-CF3-PYR1], [6979: 3-Et-4-Cl-5-CF3-PYR1], [6980: 3-Et-4-Br-5-CF3-PYR1], [6981: 3-Et-4-Me-5-CF3-PYR1], [6982: 3-Et-4-Et-5-CF3-PYR1], [6983: 3-Et-4-OMe-5-CF3 -PYR1], [6984: 3 Et-4-OEt-5-CF3-PYR1], [6985: 3-Et-4-CN-5-CF3-PYR1], [6986: 3-Et-4-c-Pr-5-CF3-PYR1] [6987: 3-Et-4-CHF2-5-CF3-PYR1], [6988: 3-Et-4-CF3-5-CF3-PYR1], [6989: 5-Me-PYR1], [6990: 3-F-5-Me-PYR1], [6991: 3-Cl-5-Me-PYR1], [6992: 3-Br-5-Me-PYR1], [6993: 3-OMe-5-Me- PYR1], [6994: 3-OEt-5-Me-PYR1], [6995: 3-CN-5-Me-PYR1], [6996: 3-c-Pr-5-Me-PYR1], [6997: 3-CHF2-5-Me-PY 1], [6998: 3-CF3-5-Me-PYR1], [6999: 4-F-5-Me-PYR1], [7000: 3-F-4-F-5-Me-PYR1],

[7001: 3-Cl-4-F-5-Me-PYR1], [7002: 3-Br-4-F-5-Me-PYR1], [7003: 3-OMe-4-F-5-Me -PYR1], [7004: 3-OEt-4-F-5-Me-PYR1], [7005: 3-CN-4-F-5-Me-PYR1], [7006: 3-c-Pr-4 -F-5-Me-PYR1], [7007: 3-CHF2-4-F-5-Me-PYR1], [7008: 3-CF3-4-F-5-Me-PYR1], [7009: 4. -Cl-5-Me-PYR1], [7010: 3-F-4-Cl-5-Me-PYR1], [7011: 3-Cl-4-Cl-5-Me-PYR1], [7012: 3 -Br-4-Cl-5-Me-PYR1], [7013: 3-OMe-4-Cl 5-Me-PYR1], [7014: 3-OEt-4-Cl-5-Me-PYR1], [7015: 3-CN-4-Cl-5-Me-PYR1], [7016: 3-c- Pr-4-Cl-5-Me-PYR1], [7017: 3-CHF2-4-Cl-5-Me-PYR1], [7018: 3-CF3-4-Cl-5-Me-PYR1], [ 7019: 4-Br-5-Me-PYR1], [7020: 3-F-4-Br-5-Me-PYR1], [7021: 3-Cl-4-Br-5-Me-PYR1], [ 7022: 3-Br-4-Br-5-Me-PYR1], [7023: 3-OMe-4-Br-5-Me-PYR1], [7024: 3-OEt-4-Br-5-Me- PYR1], [7025: 3-CN-4-Br-5-Me-P R1], [7026: 3-c-Pr-4-Br-5-Me-PYR1], [7027: 3-CHF2-4-Br-5-Me-PYR1], [7028: 3-CF3-4- Br-5-Me-PYR1], [7029: 4-Me-5-Me-PYR1], [7030: 3-F-4-Me-5-Me-PYR1], [7031: 3-Cl-4- Me-5-Me-PYR1], [7032: 3-Br-4-Me-5-Me-PYR1], [7033: 3-OMe-4-Me-5-Me-PYR1], [7034: 3- OEt-4-Me-5-Me-PYR1], [7035: 3-CN-4-Me-5-Me-PYR1], [7036: 3-c-Pr-4-Me-5-Me-PYR1] [7037: 3-CHF2-4-Me-5-Me-PYR1], [7038: 3-CF3-4-Me-5-Me-PYR1], [7039: 4-Et-5-Me-PYR1], [7040: 3-F-4-Et-5-Me-PYR1], [7041: 3-Cl-4-Et-5-Me-PYR1], [7042: 3-Br-4-Et-5-Me-PYR1], [7043: 3-OMe-4-Et-5-Me -PYR1], [7044: 3-OEt-4-Et-5-Me-PYR1], [7045: 3-CN-4-Et-5-Me-PYR1], [7046: 3-c-Pr-4 -Et-5-Me-PYR1], [7047: 3-CHF2-4-Et-5-Me-PYR1], [7048: 3-CF3-4-Et-5-Me-PYR1], [7049: 4 -OMe-5-Me-PYR1], [7050: 3-F-4 OMe-5-Me-PYR1], [7051: 3-Cl-4-OMe-5-Me-PYR1], [7052: 3-Br-4-OMe-5-Me-PYR1], [7053: 3- OMe-4-OMe-5-Me-PYR1], [7054: 3-OEt-4-OMe-5-Me-PYR1], [7055: 3-CN-4-OMe-5-Me-PYR1], [ 7056: 3-c-Pr-4-OMe-5-Me-PYR1], [7057: 3-CHF2-4-OMe-5-Me-PYR1], [7058: 3-CF3-4-OMe-5 Me-PYR1], [7059: 4-OEt-5-Me-PYR1], [7060: 3-F-4-OEt-5-Me-PYR1], [7061: 3-Cl-4-OEt-5 Me-PYR1], [7062: 3- r-4-OEt-5-Me-PYR1], [7063: 3-OMe-4-OEt-5-Me-PYR1], [7064: 3-OEt-4-OEt-5-Me-PYR1], [ 7065: 3-CN-4-OEt-5-Me-PYR1], [7066: 3-c-Pr-4-OEt-5-Me-PYR1], [7067: 3-CHF2-4-OEt-5 Me-PYR1], [7068: 3-CF3-4-OEt-5-Me-PYR1], [7069: 4-CN-5-Me-PYR1], [7070: 3-F-4-CN-5 Me-PYR1], [7071: 3-Cl-4-CN-5-Me-PYR1], [7072: 3-Br-4-CN-5-Me-PYR1], [7073: 3-OMe-4- CN-5-Me-PYR1], [7074: 3-O Et-4-CN-5-Me-PYR1], [7075: 3-CN-4-CN-5-Me-PYR1], [7076: 3-c-Pr-4-CN-5-Me-PYR1] [7077: 3-CHF2-4-CN-5-Me-PYR1], [7078: 3-CF3-4-CN-5-Me-PYR1], [7079: 4-c-Pr-5-Me- PYR1], [7080: 3-F-4-c-Pr-5-Me-PYR1], [7081: 3-Cl-4-c-Pr-5-Me-PYR1], [7082: 3-Br- 4-c-Pr-5-Me-PYR1], [7083: 3-OMe-4-c-Pr-5-Me-PYR1], [7084: 3-OEt-4-c-Pr-5-Me- PYR1], [7085: 3-CN-4-c-Pr-5-Me-PYR1], [7 86: 3-c-Pr-4-c-Pr-5-Me-PYR1], [7087: 3-CHF2-4-c-Pr-5-Me-PYR1], [7088: 3-CF3-4- c-Pr-5-Me-PYR1], [7089: 4-CHF2-5-Me-PYR1], [7090: 3-F-4-CHF2-5-Me-PYR1], [7091: 3-Cl- 4-CHF2-5-Me-PYR1], [7092: 3-Br-4-CHF2-5-Me-PYR1], [7093: 3-OMe-4-CHF2-5-Me-PYR1], [7094: 3-OEt-4-CHF2-5-Me-PYR1], [7095: 3-CN-4-CHF2-5-Me-PYR1], [7096: 3-c-Pr-4-CHF2-5-Me- PYR1], [7097: 3-CHF2- -CHF2-5-Me-PYR1], [7098: 3-CF3-4-CHF2-5-Me-PYR1], [7099: 4-CF3-5-Me-PYR1], [7100: 3-F-4. -CF3-5-Me-PYR1],

[7101: 3-Cl-4-CF3-5-Me-PYR1], [7102: 3-Br-4-CF3-5-Me-PYR1], [7103: 3-OMe-4-CF3-5-Me -PYR1], [7104: 3-OEt-4-CF3-5-Me-PYR1], [7105: 3-CN-4-CF3-5-Me-PYR1], [7106: 3-c-Pr-4 -CF3-5-Me-PYR1], [7107: 3-CHF2-4-CF3-5-Me-PYR1], [7108: 3-CF3-4-CF3-5-Me-PYR1], [7109: 5 -Et-PYR1], [7110: 3-F-5-Et-PYR1], [7111: 3-Cl-5-Et-PYR1], [7112: 3-Br-5-Et-PYR1], [7113] : 3-OMe-5-Et-PYR ], [7114: 3-OEt-5-Et-PYR1], [7115: 3-CN-5-Et-PYR1], [7116: 3-c-Pr-5-Et-PYR1], [7117: 3 -CHF2-5-Et-PYR1], [7118: 3-CF3-5-Et-PYR1], [7119: 4-F-5-Et-PYR1], [7120: 3-F-4-F-5 -Et-PYR1], [7121: 3-Cl-4-F-5-Et-PYR1], [7122: 3-Br-4-F-5-Et-PYR1], [7123: 3-OMe-4 -F-5-Et-PYR1], [7124: 3-OEt-4-F-5-Et-PYR1], [7125: 3-CN-4-F-5-Et-PYR1], [7126: 3 -C-Pr-4-F-5-Et-PYR1], [7127: 3- HF2-4-F-5-Et-PYR1], [7128: 3-CF3-4-F-5-Et-PYR1], [7129: 4-Cl-5-Et-PYR1], [7130: 3- F-4-Cl-5-Et-PYR1], [7131: 3-Cl-4-Cl-5-Et-PYR1], [7132: 3-Br-4-Cl-5-Et-PYR1], [ 7133: 3-OMe-4-Cl-5-Et-PYR1], [7134: 3-OEt-4-Cl-5-Et-PYR1], [7135: 3-CN-4-Cl-5-Et- PYR1], [7136: 3-c-Pr-4-Cl-5-Et-PYR1], [7137: 3-CHF2-4-Cl-5-Et-PYR1], [7138: 3-CF3-4- Cl-5-Et-PYR1], [7139: 4-Br-5-Et- PYR1], [7140: 3-F-4-Br-5-Et-PYR1], [7141: 3-Cl-4-Br-5-Et-PYR1], [7142: 3-Br-4-Br- 5-Et-PYR1], [7143: 3-OMe-4-Br-5-Et-PYR1], [7144: 3-OEt-4-Br-5-Et-PYR1], [7145: 3-CN- 4-Br-5-Et-PYR1], [7146: 3-c-Pr-4-Br-5-Et-PYR1], [7147: 3-CHF2-4-Br-5-Et-PYR1], [ 7148: 3-CF3-4-Br-5-Et-PYR1], [7149: 4-Me-5-Et-PYR1], [7150: 3-F-4-Me-5-Et-PYR1], [ 7151: 3-Cl-4-Me-5-Et-PYR1], [71 2: 3-Br-4-Me-5-Et-PYR1], [7153: 3-OMe-4-Me-5-Et-PYR1], [7154: 3-OEt-4-Me-5-Et- PYR1], [7155: 3-CN-4-Me-5-Et-PYR1], [7156: 3-c-Pr-4-Me-5-Et-PYR1], [7157: 3-CHF2-4- Me-5-Et-PYR1], [7158: 3-CF3-4-Me-5-Et-PYR1], [7159: 4-Et-5-Et-PYR1], [7160: 3-F-4- Et-5-Et-PYR1], [7161: 3-Cl-4-Et-5-Et-PYR1], [7162: 3-Br-4-Et-5-Et-PYR1], [7163: 3- OMe-4-Et-5-Et-PYR1], [7164: 3-OE -4-Et-5-Et-PYR1], [7165: 3-CN-4-Et-5-Et-PYR1], [7166: 3-c-Pr-4-Et-5-Et-PYR1], [7167: 3-CHF2-4-Et-5-Et-PYR1], [7168: 3-CF3-4-Et-5-Et-PYR1], [7169: 4-OMe-5-Et-PYR1], [7170: 3-F-4-OMe-5-Et-PYR1], [7171: 3-Cl-4-OMe-5-Et-PYR1], [7172: 3-Br-4-OMe-5-Et -PYR1], [7173: 3-OMe-4-OMe-5-Et-PYR1], [7174: 3-OEt-4-OMe-5-Et-PYR1], [7175: 3-CN-4-OMe. -5-Et-PYR1], [7176: 3-c-P r-4-OMe-5-Et-PYR1], [7177: 3-CHF2-4-OMe-5-Et-PYR1], [7178: 3-CF3-4-OMe-5-Et-PYR1], [ 7179: 4-OEt-5-Et-PYR1], [7180: 3-F-4-OEt-5-Et-PYR1], [7181: 3-Cl-4-OEt-5-Et-PYR1], [ 7182: 3-Br-4-OEt-5-Et-PYR1], [7183: 3-OMe-4-OEt-5-Et-PYR1], [7184: 3-OEt-4-OEt-5-Et- PYR1], [7185: 3-CN-4-OEt-5-Et-PYR1], [7186: 3-c-Pr-4-OEt-5-Et-PYR1], [7187: 3-CHF2-4- OEt-5-Et-PYR1], [71 8: 3-CF3-4-OEt-5-Et-PYR1], [7189: 4-CN-5-Et-PYR1], [7190: 3-F-4-CN-5-Et-PYR1], [ 7191: 3-Cl-4-CN-5-Et-PYR1], [7192: 3-Br-4-CN-5-Et-PYR1], [7193: 3-OMe-4-CN-5-Et- PYR1], [7194: 3-OEt-4-CN-5-Et-PYR1], [7195: 3-CN-4-CN-5-Et-PYR1], [7196: 3-c-Pr-4- CN-5-Et-PYR1], [7197: 3-CHF2-4-CN-5-Et-PYR1], [7198: 3-CF3-4-CN-5-Et-PYR1], [7199: 4- c-Pr-5-Et-PYR1], [7200: 3-F-4- -Pr-5-Et-PYR1],

[7201: 3-Cl-4-c-Pr-5-Et-PYR1], [7202: 3-Br-4-c-Pr-5-Et-PYR1], [7203: 3-OMe-4-c -Pr-5-Et-PYR1], [7204: 3-OEt-4-c-Pr-5-Et-PYR1], [7205: 3-CN-4-c-Pr-5-Et-PYR1], [7206: 3-c-Pr-4-c-Pr-5-Et-PYR1], [7207: 3-CHF2-4-c-Pr-5-Et-PYR1], [7208: 3-CF3-4 -C-Pr-5-Et-PYR1], [7209: 4-CHF2-5-Et-PYR1], [7210: 3-F-4-CHF2-5-Et-PYR1], [7211: 3-Cl -4-CHF2-5-Et-PYR1], [7212: 3-Br-4- HF2-5-Et-PYR1], [7213: 3-OMe-4-CHF2-5-Et-PYR1], [7214: 3-OEt-4-CHF2-5-Et-PYR1], [7215: 3- CN-4-CHF2-5-Et-PYR1], [7216: 3-c-Pr-4-CHF2-5-Et-PYR1], [7217: 3-CHF2-4-CHF2-5-Et-PYR1] [7218: 3-CF3-4-CHF2-5-Et-PYR1], [7219: 4-CF3-5-Et-PYR1], [7220: 3-F-4-CF3-5-Et-PYR1] [7221: 3-Cl-4-CF3-5-Et-PYR1], [7222: 3-Br-4-CF3-5-Et-PYR1], [7223: 3-OMe-4-CF3-5. Et-PYR1], [ 224: 3-OEt-4-CF3-5-Et-PYR1], [7225: 3-CN-4-CF3-5-Et-PYR1], [7226: 3-c-Pr-4-CF3-5 Et-PYR1], [7227: 3-CHF2-4-CF3-5-Et-PYR1], [7228: 3-CF3-4-CF3-5-Et-PYR1], [7229: 1-Me-PYR3] [7230: 1-Me-4-F-PYR3], [7231: 1-Me-4-Cl-PYR3], [7232: 1-Me-4-Br-PYR3], [7233: 1-Me- 4-Me-PYR3], [7234: 1-Me-4-Et-PYR3], [7235: 1-Me-4-OMe-PYR3], [7236: 1-Me-4-OEt-PYR3], [ 7237: 1-Me-4-CN-P YR3], [7238: 1-Me-4-c-Pr-PYR3], [7239: 1-Me-4-CHF2-PYR3], [7240: 1-Me-4-CF3-PYR3], [7241: 1-Me-5-F-PYR3], [7242: 1-Me-4-F-5-F-PYR3], [7243: 1-Me-4-Cl-5-F-PYR3], [7244: 1-Me-4-Br-5-F-PYR3], [7245: 1-Me-4-Me-5-F-PYR3], [7246: 1-Me-4-Et-5-F-PYR3] [7247: 1-Me-4-OMe-5-F-PYR3], [7248: 1-Me-4-OEt-5-F-PYR3], [7249: 1-Me-4-CN-5. F-PYR3], [7250: 1-Me-4-c-Pr-5-F-PYR3] [7251: 1-Me-4-CHF2-5-F-PYR3], [7252: 1-Me-4-CF3-5-F-PYR3], [7253: 1-Me-5-Cl-PYR3], [7254: 1-Me-4-F-5-Cl-PYR3], [7255: 1-Me-4-Cl-5-Cl-PYR3], [7256: 1-Me-4-Br-5-Cl -PYR3], [7257: 1-Me-4-Me-5-Cl-PYR3], [7258: 1-Me-4-Et-5-Cl-PYR3], [7259: 1-Me-4-OMe. -5-Cl-PYR3], [7260: 1-Me-4-OEt-5-Cl-PYR3], [7261: 1-Me-4-CN-5-Cl-PYR3], [7262: 1-Me -4-c-Pr-5-Cl-PYR3], [7263: 1-M -4-CHF2-6-Cl-PYR3], [7264: 1-Me-4-CF3-7-Cl-PYR3], [7265: 1-Me-5-Br-PYR3], [7266: 1-Me. -4-F-5-Br-PYR3], [7267: 1-Me-4-Cl-5-Br-PYR3], [7268: 1-Me-4-Br-5-Br-PYR3], [7269. : 1-Me-4-Me-5-Br-PYR3], [7270: 1-Me-4-Et-5-Br-PYR3], [7271: 1-Me-4-OMe-5-Br-PYR3] ], [7272: 1-Me-4-OEt-5-Br-PYR3], [7273: 1-Me-4-CN-5-Br-PYR3], [7274: 1-Me-4-c-Pr. -5-Br-PYR3], [7275: 1-Me-4-CHF2- 5-Br-PYR3], [7276: 1-Me-4-CF3-5-Br-PYR3], [7277: 1-Me-5-Me-PYR3], [7278: 1-Me-4-F- 5-Me-PYR3], [7279: 1-Me-4-Cl-5-Me-PYR3], [7280: 1-Me-4-Br-5-Me-PYR3], [7281: 1-Me- 4-Me-5-Me-PYR3], [7282: 1-Me-4-Et-5-Me-PYR3], [7283: 1-Me-4-OMe-5-Me-PYR3], [7284: 1-Me-4-OEt-5-Me-PYR3], [7285: 1-Me-4-CN-5-Me-PYR3], [7286: 1-Me-4-c-Pr-5-Me- PYR3], [7287: 1-Me-4-CHF2-5-Me-PYR ], [7288: 1-Me-4-CF3-5-Me-PYR3], [7289: 1-Me-5-Et-PYR3], [7290: 1-Me-4-F-5-Et-PYR3]. ], [7291: 1-Me-4-Cl-5-Et-PYR3], [7292: 1-Me-4-Br-5-Et-PYR3], [7293: 1-Me-4-Me-5]. -Et-PYR3], [7294: 1-Me-4-Et-5-Et-PYR3], [7295: 1-Me-4-OMe-5-Et-PYR3], [7296: 1-Me-4. -OEt-5-Et-PYR3], [7297: 1-Me-4-CN-5-Et-PYR3], [7298: 1-Me-4-c-Pr-5-Et-PYR3], [7299 : 1-Me-4-CHF2-5-Et-PYR3], [7300 1-Me-4-CF3-5-Et-PYR3],

[7301: 1-Me-5-OMe-PYR3], [7302: 1-Me-4-F-5-OMe-PYR3], [7303: 1-Me-4-Cl-5-OMe-PYR3], [7304: 1-Me-4-Br-5-OMe-PYR3], [7305: 1-Me-4-Me-5-OMe-PYR3], [7306: 1-Me-4-Et-5-OMe -PYR3], [7307: 1-Me-4-OMe-5-OMe-PYR3], [7308: 1-Me-4-OEt-5-OMe-PYR3], [7309: 1-Me-4-CN. -5-OMe-PYR3], [7310: 1-Me-4-c-Pr-5-OMe-PYR3], [7311: 1-Me-4-CHF2-5-OMe-PYR3], [7312: 1 -Me-4-CF3-5-OMe-PY 3], [7313: 1-Me-5-OEt-PYR3], [7314: 1-Me-4-F-5-OEt-PYR3], [7315: 1-Me-4-Cl-5-OEt- PYR3], [7316: 1-Me-4-Br-5-OEt-PYR3], [7317: 1-Me-4-Me-5-OEt-PYR3], [7318: 1-Me-4-Et- 5-OEt-PYR3], [7319: 1-Me-4-OMe-5-OEt-PYR3], [7320: 1-Me-4-OEt-5-OEt-PYR3], [7321: 1-Me- 4-CN-5-OEt-PYR3], [7322: 1-Me-4-c-Pr-5-OEt-PYR3], [7323: 1-Me-4-CHF2-5-OEt-PYR3], [ 7324: 1-Me-4-CF3-5-OE -PYR3], [7325: 1-Me-5-CN-PYR3], [7326: 1-Me-4-F-5-CN-PYR3], [7327: 1-Me-4-Cl-5-CN. -PYR3], [7328: 1-Me-4-Br-5-CN-PYR3], [7329: 1-Me-4-Me-5-CN-PYR3], [7330: 1-Me-4-Et. -5-CN-PYR3], [7331: 1-Me-4-OMe-5-CN-PYR3], [7332: 1-Me-4-OEt-5-CN-PYR3], [7333: 1-Me. -4-CN-5-CN-PYR3], [7334: 1-Me-4-c-Pr-5-CN-PYR3], [7335: 1-Me-4-CHF2-5-CN-PYR3], [7336: 1-Me-4-CF3-5-CN-PYR3], [ 7337: 1-Me-5-c-Pr-PYR3], [7338: 1-Me-4-F-5-c-Pr-PYR3], [7339: 1-Me-4-Cl-5-c- Pr-PYR3], [7340: 1-Me-4-Br-5-c-Pr-PYR3], [7341: 1-Me-4-Me-5-c-Pr-PYR3], [7341: 1 Me-4-Et-5-c-Pr-PYR3], [7343: 1-Me-4-OMe-5-c-Pr-PYR3], [7344: 1-Me-4-OEt-5-c- Pr-PYR3], [7345: 1-Me-4-CN-5-c-Pr-PYR3], [7346: 1-Me-4-c-Pr-5-c-Pr-PYR3], [7347: 1-Me-4-CHF2-5-c-Pr-PYR3], [7348: 1-Me-4-CF -5-c-Pr-PYR3], [7349: 1-Me-5-CHF2-PYR3], [7350: 1-Me-4-F-5-CHF2-PYR3], [7351: 1-Me-4. -Cl-5-CHF2-PYR3], [7352: 1-Me-4-Br-5-CHF2-PYR3], [7353: 1-Me-4-Me-5-CHF2-PYR3], [7354: 1. -Me-4-Et-5-CHF2-PYR3], [7355: 1-Me-4-OMe-5-CHF2-PYR3], [7356: 1-Me-4-OEt-5-CHF2-PYR3], [7357: 1-Me-4-CN-5-CHF2-PYR3], [7358: 1-Me-4-c-Pr-5-CHF2-PYR3], [7359: 1-Me-4-CHF2-5 -CHF2-PYR3] [7360: 1-Me-4-CF3-5-CHF2-PYR3], [7361: 1-Me-5-CF3-PYR3], [7362: 1-Me-4-F-5-CF3-PYR3], [7363: 1-Me-4-Cl-5-CF3-PYR3], [7364: 1-Me-4-Br-5-CF3-PYR3], [7365: 1-Me-4-Me-5-CF3 -PYR3], [7366: 1-Me-4-Et-5-CF3-PYR3], [7367: 1-Me-4-OMe-5-CF3-PYR3], [7368: 1-Me-4-OEt. -5-CF3-PYR3], [7369: 1-Me-4-CN-5-CF3-PYR3], [7370: 1-Me-4-c-Pr-5-CF3-PYR3], [7371: 1 -Me-4-CHF2-5-CF3-P YR3], [7372: 1-Me-4-CF3-5-CF3-PYR3], [7373: 1-Me-5-OPr-PYR3], [7374: 1-Me-4-F-5-OPr- PYR3], [7375: 1-Me-4-Cl-5-OPr-PYR3], [7376: 1-Me-4-Br-5-OPr-PYR3], [7377: 1-Me-4-Me- 5-OPr-PYR3], [7378: 1-Me-4-Et-5-OPr-PYR3], [7379: 1-Me-4-OMe-5-OPr-PYR3], [7380: 1-Me- 4-OEt-5-OPr-PYR3], [7381: 1-Me-4-CN-5-OPr-PYR3], [7342: 1-Me-4-c-Pr-5-OPr-PYR3], [ 7383: 1-Me-4-CHF2-5-O r-PYR3], [7384: 1-Me-4-CF3-5-OPr-PYR3], [7385: 1-Me-5-OCH2CH = CH2-PYR3], [7386: 1-Me-4-F- 5-OCH2CH = CH2-PYR3], [7387: 1-Me-4-Cl-5-OCH2CH = CH2-PYR3], [7388: 1-Me-4-Br-5-OCH2CH = CH2-PYR3], [ 7389: 1-Me-4-Me-5-OCH2CH = CH2-PYR3], [7390: 1-Me-4-Et-5-OCH2CH = CH2-PYR3], [7391: 1-Me-4-OMe- 5-OCH2CH = CH2-PYR3], [7392: 1-Me-4-OEt-5-OCH2CH = CH2-PYR3], [7393: 1-Me-4-CN-5-O. H2CH = CH2-PYR3], [7394: 1-Me-4-c-Pr-5-OCH2CH = CH2-PYR3], [7395: 1-Me-4-CHF2-5-OCH2CH = CH2-PYR3], [ 7396: 1-Me-4-CF3-5-OCH2CH = CH2-PYR3], [7397: 1-Me-5-OCH2CH = CCl2-PYR3], [7398: 1-Me-4-F-5-OCH2CH = CCl2-PYR3], [7399: 1-Me-4-Cl-5-OCH2CH = CCl2-PYR3], [7400: 1-Me-4-Br-5-OCH2CH = CCl2-PYR3],

[7401: 1-Me-4-Me-5-OCH2CH = CCl2-PYR3], [7402: 1-Me-4-Et-5-OCH2CH = CCl2-PYR3], [7403: 1-Me-4-OMe -5-OCH2CH = CCl2-PYR3], [7404: 1-Me-4-OEt-5-OCH2CH = CCl2-PYR3], [7405: 1-Me-4-CN-5-OCH2CH = CCl2-PYR3], [7406: 1-Me-4-c-Pr-5-OCH2CH = CCl2-PYR3], [7407: 1-Me-4-CHF2-5-OCH2CH = CCl2-PYR3], [7408: 1-Me-4 -CF3-5-OCH2CH = CCl2-PYR3], [7409: 1-Me-5-OCH2C≡CH-PYR3], [7410: 1-Me 4-F-5-OCH2C≡CH-PYR3], [7411: 1-Me-4-Cl-5-OCH2C≡CH-PYR3], [7412: 1-Me-4-Br-5-OCH2C≡CH— PYR3], [7413: 1-Me-4-Me-5-OCH2C≡CH-PYR3], [7414: 1-Me-4-Et-5-OCH2C≡CH-PYR3], [7415: 1-Me- 4-OMe-5-OCH2C≡CH-PYR3], [7416: 1-Me-4-OEt-5-OCH2C≡CH-PYR3], [7417: 1-Me-4-CN-5-OCH2C≡CH— PYR3], [7418: 1-Me-4-c-Pr-5-OCH2C≡CH-PYR3], [7419: 1-Me-4-CHF2-5-OCH2C≡CH-PYR3], [7420: 1- e-4-CF3-5-OCH2C≡CH-PYR3], [7421: 1-Me-5-OCH2CF3-PYR3], [7422: 1-Me-4-F-5-OCH2CF3-PYR3], [7423: 1-Me-4-Cl-5-OCH2CF3-PYR3], [7424: 1-Me-4-Br-5-OCH2CF3-PYR3], [7425: 1-Me-4-Me-5-OCH2CF3-PYR3] [7426: 1-Me-4-Et-5-OCH2CF3-PYR3], [7427: 1-Me-4-OMe-5-OCH2CF3-PYR3], [7428: 1-Me-4-OEt-5 OCH2CF3-PYR3], [7429: 1-Me-4-CN-5-OCH2CF3-PYR3], [7430: 1-Me-4-c-Pr-5-OCH2 CF3-PYR3], [7431: 1-Me-4-CHF2-5-OCH2CF3-PYR3], [7432: 1-Me-4-CF3-5-OCH2CF3-PYR3], [7433: 1-Me-5 CH2OCH3-PYR3], [7434: 1-Me-4-F-5-CH2OCH3-PYR3], [7435: 1-Me-4-Cl-5-CH2OCH3-PYR3], [7436: 1-Me-4-. Br-5-CH2OCH3-PYR3], [7437: 1-Me-4-Me-5-CH2OCH3-PYR3], [7438: 1-Me-4-Et-5-CH2OCH3-PYR3], [7439: 1- Me-4-OMe-5-CH2OCH3-PYR3], [7440: 1-Me-4-OEt-5-CH2OCH3-PYR3], [744] : 1-Me-4-CN-5-CH2OCH3-PYR3], [7442: 1-Me-4-c-Pr-5-CH2OCH3-PYR3], [7443: 1-Me-4-CHF2-5-CH2OCH3 -PYR3], [7444: 1-Me-4-CF3-5-CH2OCH3-PYR3], [7445: 1-Et-PYR3], [7446: 1-Et-4-F-PYR3], [7447: 1. -Et-4-Cl-PYR3], [7448: 1-Et-4-Br-PYR3], [7449: 1-Et-4-Me-PYR3], [7450: 1-Et-4-Et-PYR3] ], [7451: 1-Et-4-OMe-PYR3], [7452: 1-Et-4-OEt-PYR3], [7453: 1-Et-4-CN-PYR3], [7454: 1-Et. 4-c-Pr-PYR3], [7455: 1-Et-4-CHF2-PYR3], [7456: 1-Et-4-CF3-PYR3], [7457: 1-Et-5-F-PYR3] [7458: 1-Et-4-F-5-F-PYR3], [7459: 1-Et-4-Cl-5-F-PYR3], [7460: 1-Et-4-Br-5-5]. F-PYR3], [7461: 1-Et-4-Me-5-F-PYR3], [7462: 1-Et-4-Et-5-F-PYR3], [7463: 1-Et-4- OMe-5-F-PYR3], [7464: 1-Et-4-OEt-5-F-PYR3], [7465: 1-Et-4-CN-5-F-PYR3], [7466: 1- Et-4-c-Pr-5-F-PYR3], [7467: 1-Et-4-CH F2-5-F-PYR3], [7468: 1-Et-4-CF3-5-F-PYR3], [7469: 1-Et-5-Cl-PYR3], [7470: 1-Et-4- F-5-Cl-PYR3], [7471: 1-Et-4-Cl-5-Cl-PYR3], [7472: 1-Et-4-Br-5-Cl-PYR3], [7473: 1- Et-4-Me-5-Cl-PYR3], [7474: 1-Et-4-Et-5-Cl-PYR3], [7475: 1-Et-4-OMe-5-Cl-PYR3], [ 7476: 1-Et-4-OEt-5-Cl-PYR3], [7477: 1-Et-4-CN-5-Cl-PYR3], [7478: 1-Et-4-c-Pr-5-5 Cl-PYR3], [7479: 1-Et-4-CHF2-5-Cl-PY 3], [7480: 1-Et-4-CF3-5-Cl-PYR3], [7481: 1-Et-5-Br-PYR3], [7482: 1-Et-4-F-5-Br- PYR3], [7483: 1-Et-4-Cl-5-Br-PYR3], [7484: 1-Et-4-Br-5-Br-PYR3], [7485: 1-Et-4-Me- 5-Br-PYR3], [7486: 1-Et-4-Et-5-Br-PYR3], [7487: 1-Et-4-OMe-5-Br-PYR3], [7488: 1-Et- 4-OEt-5-Br-PYR3], [7489: 1-Et-4-CN-5-Br-PYR3], [7490: 1-Et-4-c-Pr-5-Br-PYR3], [ 7491: 1-Et-4-CHF2-5-Br-PYR3], [749 : 1-Et-4-CF3-5-Br-PYR3], [7493: 1-Et-5-Me-PYR3], [7494: 1-Et-4-F-5-Me-PYR3], [7495. : 1-Et-4-Cl-5-Me-PYR3], [7496: 1-Et-4-Br-5-Me-PYR3], [7497: 1-Et-4-Me-5-Me-PYR3]. ], [7498: 1-Et-4-Et-5-Me-PYR3], [7499: 1-Et-4-OMe-5-Me-PYR3], [7500: 1-Et-4-OEt-5 -Me-PYR3],

[7501: 1-Et-4-CN-5-Me-PYR3], [7502: 1-Et-4-c-Pr-5-Me-PYR3], [7503: 1-Et-4-CHF2-5 -Me-PYR3], [7504: 1-Et-4-CF3-5-Me-PYR3], [7505: 1-Et-5-Et-PYR3], [7506: 1-Et-4-F-5 -Et-PYR3], [7507: 1-Et-4-Cl-5-Et-PYR3], [7508: 1-Et-4-Br-5-Et-PYR3], [7509: 1-Et-4 -Me-5-Et-PYR3], [7510: 1-Et-4-Et-5-Et-PYR3], [7511: 1-Et-4-OMe-5-Et-PYR3], [7512: 1 -Et-4-OEt-5-Et-PYR3], [7513: 1- t-4-CN-5-Et-PYR3], [7514: 1-Et-4-c-Pr-5-Et-PYR3], [7515: 1-Et-4-CHF2-5-Et-PYR3] [7516: 1-Et-4-CF3-5-Et-PYR3], [7517: 1-Et-5-OMe-PYR3], [7518: 1-Et-4-F-5-OMe-PYR3] [7519: 1-Et-4-Cl-5-OMe-PYR3], [7520: 1-Et-4-Br-5-OMe-PYR3], [7521: 1-Et-4-Me-5- OMe-PYR3], [7522: 1-Et-4-Et-5-OMe-PYR3], [7523: 1-Et-4-OMe-5-OMe-PYR3], [7524: 1-Et-4- OEt-5-OMe-PYR3], [7525: 1- t-4-CN-5-OMe-PYR3], [7526: 1-Et-4-c-Pr-5-OMe-PYR3], [7527: 1-Et-4-CHF2-5-OMe-PYR3] [7528: 1-Et-4-CF3-5-OMe-PYR3], [7529: 1-Et-5-OEt-PYR3], [7530: 1-Et-4-F-5-OEt-PYR3] [7531: 1-Et-4-Cl-5-OEt-PYR3], [7532: 1-Et-4-Br-5-OEt-PYR3], [7533: 1-Et-4-Me-5 OEt-PYR3], [7534: 1-Et-4-Et-5-OEt-PYR3], [7535: 1-Et-4-OMe-5-OEt-PYR3], [7536: 1-Et-4- OEt-5-OEt-PYR3], [7537 : 1-Et-4-CN-5-OEt-PYR3], [7538: 1-Et-4-c-Pr-5-OEt-PYR3], [7539: 1-Et-4-CHF2-5-OEt -PYR3], [7540: 1-Et-4-CF3-5-OEt-PYR3], [7541: 1-Et-5-CN-PYR3], [7542: 1-Et-4-F-5-CN -PYR3], [7543: 1-Et-4-Cl-5-CN-PYR3], [7544: 1-Et-4-Br-5-CN-PYR3], [7545: 1-Et-4-Me. -5-CN-PYR3], [7546: 1-Et-4-Et-5-CN-PYR3], [7547: 1-Et-4-OMe-5-CN-PYR3], [7548: 1-Et. -4-OEt-5-CN-PYR3], [7549: 1-E -4-CN-5-CN-PYR3], [7550: 1-Et-4-c-Pr-5-CN-PYR3], [7551: 1-Et-4-CHF2-5-CN-PYR3], [7552: 1-Et-4-CF3-5-CN-PYR3], [7553: 1-Et-5-c-Pr-PYR3], [7554: 1-Et-4-F-5-c-Pr -PYR3], [7555: 1-Et-4-Cl-5-c-Pr-PYR3], [7556: 1-Et-4-Br-5-c-Pr-PYR3], [7557: 1-Et. -4-Me-5-c-Pr-PYR3], [7558: 1-Et-4-Et-5-c-Pr-PYR3], [7559: 1-Et-4-OMe-5-c-Pr -PYR3], [7560: 1-Et-4-OEt-5-c-Pr-PYR3], [ 561: 1-Et-4-CN-5-c-Pr-PYR3], [7562: 1-Et-4-c-Pr-5-c-Pr-PYR3], [7563: 1-Et-4- CHF2-5-c-Pr-PYR3], [7564: 1-Et-4-CF3-5-c-Pr-PYR3], [7565: 1-Et-5-CHF2-PYR3], [7566: 1- Et-4-F-5-CHF2-PYR3], [7567: 1-Et-4-Cl-5-CHF2-PYR3], [7568: 1-Et-4-Br-5-CHF2-PYR3], [ 7569: 1-Et-4-Me-5-CHF2-PYR3], [7570: 1-Et-4-Et-5-CHF2-PYR3], [7571: 1-Et-4-OMe-5-CHF2- PYR3], [7572: 1-Et-4-OEt -5-CHF2-PYR3], [7573: 1-Et-4-CN-5-CHF2-PYR3], [7574: 1-Et-4-c-Pr-5-CHF2-PYR3], [7575: 1. -Et-4-CHF2-5-CHF2-PYR3], [7576: 1-Et-4-CF3-5-CHF2-PYR3], [7577: 1-Et-5-CF3-PYR3], [7578: 1 -Et-4-F-5-CF3-PYR3], [7579: 1-Et-4-Cl-5-CF3-PYR3], [7580: 1-Et-4-Br-5-CF3-PYR3], [7581: 1-Et-4-Me-5-CF3-PYR3], [7582: 1-Et-4-Et-5-CF3-PYR3], [7583: 1-Et-4-OMe-5-CF3 -PYR3], [7584: 1 Et-4-OEt-5-CF3-PYR3], [7585: 1-Et-4-CN-5-CF3-PYR3], [7586: 1-Et-4-c-Pr-5-CF3-PYR3] [7587: 1-Et-4-CHF2-5-CF3-PYR3], [7588: 1-Et-4-CF3-5-CF3-PYR3], [7589: 1-Et-5-OPr-PYR3] [7590: 1-Et-4-F-5-OPr-PYR3], [7591: 1-Et-4-Cl-5-OPr-PYR3], [7592: 1-Et-4-Br-5-5. OPr-PYR3], [7593: 1-Et-4-Me-5-OPr-PYR3], [7594: 1-Et-4-Et-5-OPr-PYR3], [7595: 1-Et-4- OMe-5-OPr-PYR3], [75 6: 1-Et-4-OEt-5-OPr-PYR3], [7597: 1-Et-4-CN-5-OPr-PYR3], [7598: 1-Et-4-c-Pr-5-5 OPr-PYR3], [7599: 1-Et-4-CHF2-5-OPr-PYR3], [7600: 1-Et-4-CF3-5-OPr-PYR3],

[7601: 1-Et-5-OCH2CH = CH2-PYR3], [7602: 1-Et-4-F-5-OCH2CH = CH2-PYR3], [7603: 1-Et-4-Cl-5-OCH2CH = CH2-PYR3], [7604: 1-Et-4-Br-5-OCH2CH = CH2-PYR3], [7605: 1-Et-4-Me-5-OCH2CH = CH2-PYR3], [7606: 1 -Et-4-Et-5-OCH2CH = CH2-PYR3], [7607: 1-Et-4-OMe-5-OCH2CH = CH2-PYR3], [7608: 1-Et-4-OEt-5-OCH2CH = CH2-PYR3], [7609: 1-Et-4-CN-5-OCH2CH = CH2-PYR3], [7610: 1-Et-4-c-Pr-5-OC. 2CH = CH2-PYR3], [7611: 1-Et-4-CHF2-5-OCH2CH = CH2-PYR3], [7612: 1-Et-4-CF3-5-OCH2CH = CH2-PYR3], [7613: 1-Et-5-OCH2CH = CCl2-PYR3], [7614: 1-Et-4-F-5-OCH2CH = CCl2-PYR3], [7615: 1-Et-4-Cl-5-OCH2CH = CCl2- PYR3], [7616: 1-Et-4-Br-5-OCH2CH = CCl2-PYR3], [7617: 1-Et-4-Me-5-OCH2CH = CCl2-PYR3], [7618: 1-Et- 4-Et-5-OCH2CH = CCl2-PYR3], [7619: 1-Et-4-OMe-5-OCH2CH = CCl2-PYR3 [7620: 1-Et-4-OEt-5-OCH2CH = CCl2-PYR3], [7621: 1-Et-4-CN-5-OCH2CH = CCl2-PYR3], [7622: 1-Et-4- c-Pr-5-OCH2CH = CCl2-PYR3], [7623: 1-Et-4-CHF2-5-OCH2CH = CCl2-PYR3], [7624: 1-Et-4-CF3-5-OCH2CH = CCl2- PYR3], [7625: 1-Et-5-OCH2C≡CH-PYR3], [7626: 1-Et-4-F-5-OCH2C≡CH-PYR3], [7627: 1-Et-4-Cl- 5-OCH2C≡CH-PYR3], [7628: 1-Et-4-Br-5-OCH2C≡CH-PYR3], [7629: 1-Et-4-Me-5-OC H2C≡CH-PYR3], [7630: 1-Et-4-Et-5-OCH2C≡CH-PYR3], [7631: 1-Et-4-OMe-5-OCH2C≡CH-PYR3], [7632: 1-Et-4-OEt-5-OCH2C≡CH-PYR3], [7633: 1-Et-4-CN-5-OCH2C≡CH-PYR3], [7634: 1-Et-4-c-Pr- 5-OCH2C≡CH-PYR3], [7635: 1-Et-4-CHF2-5-OCH2C≡CH-PYR3], [7636: 1-Et-4-CF3-5-OCH2C≡CH-PYR3], [7 7637: 1-Et-5-OCH2CF3-PYR3], [7638: 1-Et-4-F-5-OCH2CF3-PYR3], [7639: 1-Et-4-Cl-5-OCH2CF -PYR3], [7640: 1-Et-4-Br-5-OCH2CF3-PYR3], [7641: 1-Et-4-Me-5-OCH2CF3-PYR3], [7642: 1-Et-4-Et -5-OCH2CF3-PYR3], [7643: 1-Et-4-OMe-5-OCH2CF3-PYR3], [7644: 1-Et-4-OEt-5-OCH2CF3-PYR3], [7645: 1-Et -4-CN-5-OCH2CF3-PYR3], [7646: 1-Et-4-c-Pr-5-OCH2CF3-PYR3], [7647: 1-Et-4-CHF2-5-OCH2CF3-PYR3], [7648: 1-Et-4-CF3-5-OCH2CF3-PYR3], [7649: 1-Et-5-CH2OCH3-PYR3], [76 0: 1-Et-4-F-5-CH2OCH3-PYR3], [7651: 1-Et-4-Cl-5-CH2OCH3-PYR3], [7652: 1-Et-4-Br-5-CH2OCH3- PYR3], [7653: 1-Et-4-Me-5-CH2OCH3-PYR3], [7654: 1-Et-4-Et-5-CH2OCH3-PYR3], [7655: 1-Et-4-OMe- 5-CH2OCH3-PYR3], [7656: 1-Et-4-OEt-5-CH2OCH3-PYR3], [7657: 1-Et-4-CN-5-CH2OCH3-PYR3], [7658: 1-Et- 4-c-Pr-5-CH2OCH3-PYR3], [7659: 1-Et-4-CHF2-5-CH2OCH3-PYR3], [7660: 1-Et-4 -CF3-5-CH2OCH3-PYR3]

Next, formulation examples are shown.
Formulation Example 1
A preparation is obtained by thoroughly pulverizing and mixing 50 parts of any one of the present compounds A, 3 parts of calcium lignin sulfonate, 2 parts of magnesium lauryl sulfate, and 45 parts of synthetic silicon hydroxide.

Formulation Example 2
After mixing 20 parts of any one compound of this compound A and 1.5 parts of sorbitan trioleate with 28.5 parts of an aqueous solution containing 2 parts of polyvinyl alcohol, Into this, 40 parts of an aqueous solution containing 0.05 part of xanthan gum and 0.1 part of aluminum magnesium silicate is added, and further 10 parts of propylene glycol is added and stirred to obtain a preparation.

Formulation Example 3
A formulation is obtained by thoroughly pulverizing and mixing 2 parts of any one compound of Compound A, 88 parts of kaolin clay and 10 parts of talc.

Formulation Example 4
A preparation is obtained by thoroughly mixing 5 parts of any one of the present compounds A, 14 parts of polyoxyethylene styrylphenyl ether, 6 parts of calcium dodecylbenzenesulfonate and 75 parts of xylene.

Formulation Example 5
After thoroughly mixing 2 parts of any one compound A, 1 part of synthetic hydrous silicon oxide, 2 parts of calcium lignin sulfonate, 30 parts of bentonite and 65 parts of kaolin clay, water is added and kneaded and granulated. The preparation is obtained by drying.

Formulation Example 6
By mixing 10 parts of any one compound of this compound A; 35 parts of white carbon containing 50 parts of polyoxyethylene alkyl ether sulfate ammonium salt; and 55 parts of water, and finely pulverizing them by a wet pulverization method. Get the formulation.

Next, test examples show that the compounds of the present invention are useful for pest control.
The control effect is to visually observe the area of the lesion on the test plant at the time of the survey, and to compare the area of the lesion on the plant treated with the compound of the present invention and the area of the lesion on the untreated plant. It was evaluated by.
Test example 1
A plastic pot was filled with soil, rice (cultivar; Nipponbare) was sown therein, and grown in a greenhouse for 20 days. Thereafter, a dilute water adjusted to contain any one of the compounds 11, 13 or 16 of the present invention so as to contain a predetermined concentration (500 ppm) was sprayed on the foliage so as to sufficiently adhere to the leaf surface of the rice. After spraying, the plants were air-dried, and the sprayed rice was contacted with rice seedlings (variety: Nihonbare) affected by rice blast fungus (Magnaporthe grisea) under high humidity at 24 ° C in the daytime and 20 ° C at night. After leaving for days, the lesion area was examined. As a result, the lesion area in the plant treated with the compound 11, 13 or 16 of the present invention was 30% or less of the lesion area in the untreated plant.

Test example 2
A plastic pot was filled with soil, rice (cultivar; Nipponbare) was sown therein, and grown in a greenhouse for 20 days. Thereafter, a dilute water prepared by containing any one of the compounds 1, 10 or 15 of the present invention so as to contain a predetermined concentration (200 ppm) was sprayed on the foliage so as to sufficiently adhere to the leaf surface of the rice. After spraying, the plants were air-dried, and the sprayed rice was contacted with rice seedlings (variety: Nihonbare) affected by rice blast fungus (Magnaporthe grisea) under high humidity at 24 ° C in the daytime and 20 ° C at night. After leaving for days, the lesion area was examined. As a result, the lesion area in the plant treated with the present compound 1, 10 or 15 was 30% or less of the lesion area in the untreated plant.

Test example 3
A plastic pot was filled with soil, and barley (variety: Nishinohoshi) was sown therein and grown in a greenhouse for 7 days. A water dilution adjusted to contain a predetermined concentration (500 ppm) of any one of the compounds 1 or 3 to 16 of the present invention was sprayed on the foliage so as to adhere well to the leaf surface of the barley. After spraying, the plants were air-dried, and two days later, an aqueous suspension of barley net spore fungus (Pyrenophora teres) spores was spray-inoculated. After inoculation, the plants were placed under high humidity in a greenhouse at 23 ° C. during the day and 20 ° C. during the night, and then cultivated in the greenhouse for 7 days. As a result, the lesion area in the plant treated with the present compound 1 or 3 to 16 was 30% or less of the lesion area in the untreated plant.

Test example 4
A plastic pot was stuffed with soil, seeded with green beans (variety; Nagahama peas) and grown in a greenhouse for 8 days. A dilute water adjusted to contain any one of the compounds 4 or 6 of the present invention so as to contain a predetermined concentration (500 ppm) was sprayed on the foliage so that it sufficiently adheres to the kidney leaf surface. After spraying, the plants were air-dried, and a mycelia-containing PDA medium of sclerotia sclerotium was placed on the kidney leaf surface. After the inoculation, all kidney beans were placed under high humidity only at night, and the lesion area was examined 4 days after the inoculation. As a result, the lesion area in the plant treated with the compound 4 or 6 of the present invention was 30% or less of the lesion area in the untreated plant.

Test Example 5
A plastic pot was filled with soil, and wheat (variety: Apogee) was sown therein and grown in a greenhouse for 10 days. The water dilution adjusted to contain any one of the compounds 1 to 8 or 10 to 16 of the present invention in a predetermined concentration (500 ppm) was sprayed on the foliage so as to adhere sufficiently to the leaf surface of the wheat. After spraying, the plants were air-dried, and after 4 days, sprayed with a water suspension of Septoria tritici spores. After inoculation, the plants were placed under high humidity at 18 ° C. for 3 days, then placed under illumination for 14 to 18 days, and then the lesion area was examined. As a result, the lesion area in the plant treated with the present compounds 1-8 or 10-16 was 30% or less of the lesion area in the untreated plant.

Test Example 6
A plastic pot was filled with soil, and wheat (variety: Apogee) was sown therein and grown in a greenhouse for 10 days. Thereafter, the wheat was spray-inoculated with an aqueous suspension of Septoria tritici spores. The wheat was placed under high humidity at 18 ° C. for 3 days and then air-dried. Dispersion of the water dilution adjusted to contain a predetermined concentration (200 ppm) of any one of the compounds 1, 7, 8, 12 or 14 to 16 of the present invention so as to adhere sufficiently to the leaf surface of the wheat. did. After spraying, the plants were air-dried and placed under illumination for 14 to 18 days, and then the lesion area was examined. As a result, the lesion area in the plant treated with the present compound 1, 7, 8, 12 or 14 to 16 was 30% or less of the lesion area in the untreated plant.

Test Example 7
A plastic pot was filled with soil, and wheat (variety: Apogee) was sown therein and grown in a greenhouse for 10 days. Thereafter, the wheat was spray-inoculated with an aqueous suspension of Septoria tritici spores. The wheat was placed under high humidity at 18 ° C. for 3 days and then air-dried. A dilute water adjusted to contain a predetermined concentration (50 ppm) of the compound 3 of the present invention was sprayed on the foliage so as to adhere sufficiently to the leaf surface of the wheat. After spraying, the plants were air-dried and placed under illumination for 14 to 18 days, and then the lesion area was examined. As a result, the lesion area in the plant treated with the compound 3 of the present invention was 30% or less of the lesion area in the untreated plant.

Test Example 8
A plastic pot was filled with soil, and wheat (variety: Shirogane) was sown therein and allowed to grow in a greenhouse for 9 days. A water dilution adjusted to contain a predetermined concentration (200 ppm) of any one of the compounds 12 or 14 to 16 of the present invention was sprayed on the foliage so as to adhere well to the leaf surface of the wheat. After spraying, the plants were air-dried and cultivated at 20 ° C. under illumination for 5 days, and then sprinkled with spores of wheat rust fungus (Puccinia recondita). After inoculation, the plants were placed at 23 ° C. under dark and humid conditions for 1 day, then cultivated at 20 ° C. under illumination for 8 days, and the lesion area was examined. As a result, the lesion area in the plant treated with the present compound 12 or 14 to 16 was 30% or less of the lesion area in the untreated plant.

Test Example 9
A plastic pot was filled with soil, and barley (variety: Mikamo Golden) was sown there and allowed to grow in a greenhouse for 7 days. A water dilution adjusted to contain a predetermined concentration (200 ppm) of any one of the compounds 14, 15 or 16 of the present invention was sprayed on the foliage so as to adhere well to the leaf surface of the barley. After spraying, the plants were air-dried, and after 2 days, sprayed with a water suspension of barley cloud spore (Rhynchosporium secalis) spores. After inoculation, the plants were placed under high humidity in a greenhouse at 23 ° C. during the day and 20 ° C. during the night, and then cultivated in the greenhouse for 7 days. As a result, the lesion area in the plant treated with the compound 14, 15 or 16 of the present invention was 30% or less of the lesion area in the untreated plant.

Test Example 10
A plastic pot was filled with soil, and cucumber (variety: Sagamihanjiro) was sown there and allowed to grow in a greenhouse for 12 days. A water dilution adjusted to contain any one of the compounds of the present invention compounds 3-5, 12, 14 or 16 at a predetermined concentration (500 ppm) was sprayed on the foliage so that it sufficiently adhered to the cucumber leaf surface. After spraying, the plants were air-dried and sprinkled with spore powdery mildew (Sphaerotheca furiginea) spores. The plants were cultivated in a greenhouse at 24 ° C. during the day and 20 ° C. during the night for 8 days, and then the lesion area was examined. As a result, the lesion area in the plant treated with the present compounds 3-5, 12, 14, or 16 was 30% or less of the lesion area in the untreated plant.

Test Example 11
A plastic pot was filled with soil, and cucumber (variety: Sagamihanjiro) was sown there and allowed to grow in a greenhouse for 19 days. A dilute water adjusted to contain the present compound 6 at a predetermined concentration (200 ppm) was sprayed on the foliage so as to adhere sufficiently to the cucumber leaf surface. After spraying, the plants were air-dried, and one day later, sprayed and inoculated with a water suspension of cucumber brown spot fungus (Corynespora cassicola) spores. After inoculation, the plants were cultivated for 7 days under high humidity at 24 ° C in the daytime and 20 ° C at night, and then the lesion area was examined. As a result, the lesion area in the plant treated with the compound 6 of the present invention was 30% or less of the lesion area in the untreated plant.

Test Example 12
A plastic pot was filled with soil, and cucumber (variety: Sagamihanjiro) was sown there and allowed to grow in a greenhouse for 19 days. A water dilution adjusted to contain any one of the present compounds 11 to 13, 15 or 16 at a predetermined concentration (200 ppm) was sprayed on the foliage so that it sufficiently adhered to the cucumber leaf surface. After spraying, the plants were air-dried, and one day later, sprayed and inoculated with an aqueous suspension of cucumber anthracnose fungus (Colletotrichum lagenarium) spores. After inoculation, it was first placed at 23 ° C. under high humidity for 1 day, and then cultivated in a greenhouse at 24 ° C. during the day and 20 ° C. during the night, and then the lesion area was examined. As a result, the lesion area in the plant treated with the present compounds 11 to 13, 15 or 16 was 30% or less of the lesion area in the untreated plant.

Test Example 13
The compound 9 of the present invention was diluted with water so that the active ingredient concentration was 500 ppm to prepare a test drug solution.
A filter paper of the same size was laid on the bottom of a polyethylene cup having a diameter of 5.5 cm, 0.7 ml of the test chemical solution was dropped onto the filter paper, and 30 mg of sucrose was uniformly added as food. Ten female fly (Musca domestica) females were released into the polyethylene cup and capped. The life and death of the housefly was investigated 24 hours later, and the mortality rate was calculated by the following formula.
Death rate (%) = (Number of dead insects / number of test insects) × 100
As a result, the treatment with Compound 9 of the present invention showed a mortality rate of 100%.

Test Example 14
The compound of the present invention 12 or 14 was diluted with water so that the active ingredient concentration was 500 ppm to prepare a test chemical solution.
Cabbage (variety: green ball) was planted in a polyethylene cup and allowed to grow until the third or fourth true leaf developed. The test chemical was sprayed on the cabbage at a rate of 20 mL / cup. After the chemical solution was dried, cabbage cut out from the root was placed in a polyethylene cup with a diameter of 5.5 cm covered with filter paper, and 5 third-instar larvae (Plutella xylostella) were released and capped. After storing at 25 ° C., the number of live insects was counted after 5 days, and the death rate was calculated from the following formula.
Death rate (%) = (Number of dead insects / number of test insects) × 100
As a result, the treatment group of the test chemical solution of the present compound 12 or 14 showed a death rate of 80% or more.

Test Example 15
The compound 12 of the present invention was diluted with water so that the active ingredient concentration was 500 ppm to prepare a test chemical solution.
30 cotton aphids (including adults and larvae) were released on the cucumber (variety: Sagamihanshirabushi adult) grown until the first true leaf developed in a polyethylene cup, and the above test solution was used the next day. 20 mL was sprayed. Six days later, the number of surviving insects was counted, and the control value was determined by the following formula.
Control value (%) = {1− (Cb × Tai) / (Cai × Tb)} × 100
In addition, the character in a formula represents the following meaning.
Cb: Number of insects before spraying chemical solution in untreated group Cai: Number of live insects in untreated group Tb: Number of insects before spraying chemical solution in treated group Tai: Number of live insects in treated group As a result, the present compound 12 was controlled The value was 90% or more.

Claims (6)

Formula (1)

[Where,
R ⁵ represents a C1-C3 alkyl group optionally having one or more halogen atoms;
E represents a divalent 5-membered heteroaryl group or a divalent 6-membered heteroaryl group;
Y _{is, * - (CH 2) n} -G - &, * - G- (CH 2) n - &, * - G- (CH 2) n -G - &, * - G-CH 2 CH 2 - _{G-CH 2 CH 2 -G -} &, * - CH 2 -G-CH 2 CH 2 -G - &, * - G-CH 2 CH 2 -G-CH 2 - &, * - CH = CH- & , * - CH = CH-G - &, * - G-CH = CH - &, * - CH = CH-CH 2 -G - &, * - G-CH 2 -CH = CH - &, * - G _{-CH = CH-CH 2 - &} , * - CH 2 -CH = CH-G - &, * - CH = CH-G-CH 2 - &, * - CH 2 -G-CH = CH - &, * _{-CH = CH-CH 2 -G-} CH 2 - &, * - CH 2 -G-CH 2 -CH = CH - &, * - CH = CH-G-CH 2 CH 2 - &, * - CH 2 CH ₂ -G-CH = CH- & _{* -G-CH = CH-CH} 2 CH 2 - &, * - CH 2 CH 2 -CH = CH-G - &, * - CH = CH-G-CH = CH - &, * - C≡C- _{&, * - C≡C-CH 2} -G - &, * - G-CH 2 -C≡C - &, * - C≡C-CH 2 -G-CH 2 - & or * _-CH 2 -G —CH ₂ —C≡C— & (wherein all hydrogen atoms in Y (including hydrogen atoms in G) are one or more atoms selected from the group consisting of halogen atoms and C1-C3 alkyl groups) Or when substituted with two or more atoms or groups, the atoms and groups may be the same or different; G represents an oxygen atom, a sulfur atom, or NR ^B ; R ^B represents a hydrogen atom or a C1-C3 alkyl group, n represents an integer from 1 to 10. Furthermore, our in Y Te, * represents the bonding position with Q, & represents a bonding position to E).;
Q is a divalent C6-C10 aryl group (provided that the bivalent C6-C10 aryl group may have one or more atoms or groups selected from the group ^{P 2.)} Or divalent 5-10-membered heterocyclic group (provided that the divalent 5-10-membered heterocyclic group may have one or more atoms or groups selected from group P ² , and a nitrogen atom as a ring-constituting atom, 1 or more atoms selected from the group consisting of an oxygen atom and a sulfur atom are contained, and when 2 or more atoms are contained, these atoms may be the same or different.
X represents an oxygen atom or a sulfur atom;
A represents a C6-C10 aryl group, an adamantyl group, a C6-C10 aryloxy group, a C6-C10 arylthio group, a C6-C10 arylamino group, a C3-C10 cycloalkyl group, a 5-10 membered heterocyclic group, 5-10 membered heteroaryl group, 5-10-membered heteroarylthio group, 5-10 membered heteroaryl amino group, C6-C10 arylsulfonyl group, C6-C10 arylsulfinyl group or 1 or 2 groups selected from the group ^{P 3,} -CH = NH which may have (provided that the 5-10 membered heterocyclic group, the 5-10 membered heteroaryloxy group, the 5-10 membered heteroarylthio group and the 5-10 member The heteroarylamino group contains one or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom as ring constituent atoms. When two or more atoms are contained, the atoms may be the same or different, and the 5-10 membered heterocyclic group, the 5-10 membered heteroaryloxy group, the 5-10 membered heteroarylthio group groups and 5-10 membered heteroaryl amino group may have one or more atoms or groups selected from the group P ^1, if having two or more atoms or groups, the atom or group are the same or different May be different,
When the —CH═NH has two groups selected from the group P ³ , the groups may be the same or different;
The C6-C10 aryl group, the adamantyl group, the C6-C10 aryloxy group, the C6-C10 arylthio group, the C6-C10 arylamino group, the C3-C10 cycloalkyl group, the C6-C10 arylsulfonyl group and the C6-C10 arylsulfinyl group may have one or more atoms or groups selected from the group P ^1, if having two or more atoms or groups, the atom or group are identical or different Also good. ).
Group P ¹ : halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkenyl group, C2-C6 haloalkenyl group, C2-C6 alkynyl group, C2-C6 haloalkynyl group, C3-C6 cycloalkyl Group, C3-C6 halocycloalkyl group, C1-C6 alkoxy group, C1-C6 haloalkoxy group, C1-C6 alkylthio group, C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyl group Oxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3-C6 haloalkenyloxy group, C3-C6 haloalkynyloxy group, C3-C6 alkenylthio group, C3-C6 Alkynylthio group, C3-C6 haloalkenylthio group, C -C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group, C2-C6 alkylcarbonylthio group, carboxy group, formyl group, C2-C6 alkoxycarbonyl group, It may have a nitro group, a cyano group, a hydroxy group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, or a C1-C6 alkyl group. A group consisting of an amino group, an aminosulfonyl group optionally having a C1-C6 alkyl group, and an aminocarbonyl group optionally having a C1-C6 alkyl group;
Group P ² : halogen atom, cyano group, C3-C6 cycloalkyl group, C3-C6 halocycloalkyl group, C1-C4 alkoxy group, C1-C4 haloalkoxy group, C1-C4 alkylthio group and C1-C4 haloalkylthio group A group consisting of:
Group P ³ : a group consisting of a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C6 cycloalkyl group, and a C3-C6 halocycloalkyl group;
A tetrazolinone compound represented by: E is any one of groups selected from the group P ^4, tetrazolinone compound according to claim 1, wherein.
Group P ⁴ : Group consisting of E1 to E7

[In the formula, # represents a bonding position with a tetrazolinone ring, and $ represents a bonding position with Y. Z ¹ represents a nitrogen atom or CR ¹ ;
Z ² represents a nitrogen atom or CR ² ;
Z ³ represents a nitrogen atom or CR ³ ;
Z ⁴ represents a nitrogen atom or CR ⁴ ;
Y ¹ represents an oxygen atom, a sulfur atom or NR ⁸ ;
Y ² represents an oxygen atom, a sulfur atom or NR ⁶ ;
Y ³ represents an oxygen atom, a sulfur atom or NR ⁷ ;
R ¹ is a hydrogen atom, C1-C6 alkyl group, C3-C6 cycloalkyl group, halogen atom, C1-C6 haloalkyl group, C2-C6 alkenyl group, C1-C6 alkoxy group, C1-C6 alkylthio group, C2-C6. Alkynyl group, nitro group, cyano group, aminocarbonyl group optionally having C1-C6 alkyl group, C2-C6 haloalkenyl group, C2-C6 haloalkynyl group, C3-C6 halocycloalkyl group, C1-C6 Haloalkoxy group, C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyloxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3 -C6 haloalkenyloxy group, C3-C6 haloalkynyloxy group, C3 -C6 alkenylthio group, C3-C6 alkynylthio group, C3-C6 haloalkenylthio group, C3-C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group , C2-C6 alkylcarbonylthio group, C2-C6 alkoxycarbonyl group, hydroxy group, thiol group, amino group optionally having C1-C6 alkyl group, pentafluorosulfanyl group, C3-C9 trialkylsilyl group, C5-C14 trialkylsilylethynyl group, C1-C4 alkylsulfonyl group, C1-C4 haloalkylsulfonyl group, C1-C4 alkylsulfinyl group, C1-C4 haloalkylsulfinyl group, C2-C5 alkoxyalkyl group or C2-C5 alkylthio group It represents an alkyl group;
R ² , R ³ and R ⁴ are each independently a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 haloalkyl group, a C2-C3 alkenyl group, a C2-C3 haloalkenyl group or a C1-C3 alkoxy group. Represents;
R ⁶ and R ⁷ each independently represents a hydrogen atom, a C1-C3 alkyl group, a C1-C3 haloalkyl group, a C2-C3 alkenyl group, a C2-C3 haloalkenyl group or a C1-C3 alkoxy group;
R ⁸ is a hydrogen atom, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C1-C6 alkylthio group, a C2-C6 alkynyl group, Nitro group, cyano group, aminocarbonyl group optionally having C1-C6 alkyl group, C2-C6 haloalkenyl group, C2-C6 haloalkynyl group, C3-C6 halocycloalkyl group, C1-C6 haloalkoxy group , C1-C6 haloalkylthio group, C3-C6 cycloalkyloxy group, C3-C6 halocycloalkyloxy group, C3-C6 cycloalkylthio group, C3-C6 alkenyloxy group, C3-C6 alkynyloxy group, C3-C6 halo Alkenyloxy group, C3-C6 haloalkynyloxy group, C3-C6 alkeni Ruthio group, C3-C6 alkynylthio group, C3-C6 haloalkenylthio group, C3-C6 haloalkynylthio group, C2-C6 alkylcarbonyl group, C2-C6 haloalkylcarbonyl group, C2-C6 alkylcarbonyloxy group, C2- C6 alkylcarbonylthio group, C2-C6 alkoxycarbonyl group, hydroxy group, amino group optionally having C1-C6 alkyl group, pentafluorosulfanyl group, C3-C9 trialkylsilyl group, C5-C14 trialkylsilyl group An ethynyl group, a C1-C4 alkylsulfonyl group, a C1-C4 haloalkylsulfonyl group, a C1-C4 alkylsulfinyl group, a C1-C4 haloalkylsulfinyl group, a C2-C5 alkoxyalkyl group or a C2-C5 alkylthioalkyl group is represented. ] Y is -O-CH ₂ - tetrazolinone compound of according to claim 1 or 2, wherein a.   A pest control agent comprising the tetrazolinone compound according to any one of claims 1 to 3.   A method for controlling pests, wherein an effective amount of the tetrazolinone compound according to any one of claims 1 to 3 is applied to a plant or soil.   Use of the tetrazolinone compound according to any one of claims 1 to 3 for controlling pests.