JPS6490151A - Production of menadione - Google Patents
Production of menadioneInfo
- Publication number
- JPS6490151A JPS6490151A JP62246363A JP24636387A JPS6490151A JP S6490151 A JPS6490151 A JP S6490151A JP 62246363 A JP62246363 A JP 62246363A JP 24636387 A JP24636387 A JP 24636387A JP S6490151 A JPS6490151 A JP S6490151A
- Authority
- JP
- Japan
- Prior art keywords
- menadione
- catalyst
- naphthol
- reused
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PURPOSE:To obtain menadione which is used as a synthetic intermediate of medicines such as vitamin K1 or K2 or as vitamin K3 in high yield under mild reaction conditions, by catalytic oxidation of 2-methyl-1-naphthol with molecular oxygen in a specific solvent using an inexpensive catalyst. CONSTITUTION:Using an aqueous solution of cupric chloride and lithium chloride as a catalyst, 2-methyl-1-naphthol is brought into contact with molecular oxygen in a reaction solvent which has an appropriate hydrophilicity and lipophilicity such as a mixture of a lower aliphatic alcohol of 1-4C carbon atoms such as ethanol with an aromatic hydrocarbon such as benzene or a single long-chain aliphatic alcohol of 5-10C carbon atoms such as n-hexanol or a combination thereof at 30-80 deg.C for 2-7hr, further the contact is continued for more 1-3hr to effect the oxidation whereby menadione is obtained. According to the present process, the isolation and purification of the subject product, menadione becomes easy, the solution after salting-out can be reused as a catalyst solution, further, recovered solvent mixture also can be reused.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62246363A JPH0819033B2 (en) | 1987-09-30 | 1987-09-30 | Manufacturing method of menadione |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62246363A JPH0819033B2 (en) | 1987-09-30 | 1987-09-30 | Manufacturing method of menadione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6490151A true JPS6490151A (en) | 1989-04-06 |
| JPH0819033B2 JPH0819033B2 (en) | 1996-02-28 |
Family
ID=17147440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62246363A Expired - Lifetime JPH0819033B2 (en) | 1987-09-30 | 1987-09-30 | Manufacturing method of menadione |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0819033B2 (en) |
-
1987
- 1987-09-30 JP JP62246363A patent/JPH0819033B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0819033B2 (en) | 1996-02-28 |
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