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Priority to JP10679087ApriorityCriticalpatent/JPS6485972A/en
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:A sesquiterpenelactone derivative shown by the formula [R1 is H or OR' (R' is H, alkyl or acryl); R2 and R3 are CH2= or R2 is H and R3 is -CH2 or OR']. EXAMPLE:Guternbergin. USE:A drug. An active ingredient for carcinostatic agent. The derivative is an eudesmanolinde-based compound, has low side effects and shows strongly carcinostatic activity. Especially a new sesquiterpenelactone derivative named gutenbergin belonging to eudesmanolide shows strong cytotoxicity on leukemia and is expected to the effective against adult T-cell leukemia and AIDS, diseases based on HTLV. PREPARATION:Leaves of higher plant Gutenbergia Cordifilia named idoma, belonging to the family Compositae are extracted with an organic solvent such as chloroform, fractionated by column chromatography using silica gel, separated and purified to give a compound shown by the formula.
JP10679087A1987-04-301987-04-30Carcinostatic agent and production thereof
PendingJPS6485972A
(en)
NEW DERIVATIVES OF PENTACYCLIC ALKALOIDS, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICINAL PRODUCTS, AND THEIR APPLICATION TO THE SYNTHESIS OF PRODUCTS OF THE EBURNAMONINE GROUP