JPS6479111A - Sustained release preparation and production thereof - Google Patents

Sustained release preparation and production thereof

Info

Publication number
JPS6479111A
JPS6479111A JP63110791A JP11079188A JPS6479111A JP S6479111 A JPS6479111 A JP S6479111A JP 63110791 A JP63110791 A JP 63110791A JP 11079188 A JP11079188 A JP 11079188A JP S6479111 A JPS6479111 A JP S6479111A
Authority
JP
Japan
Prior art keywords
drug
polymer
water
sustained release
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63110791A
Other languages
Japanese (ja)
Other versions
JPH075458B2 (en
Inventor
Muneo Nonomura
Yasuyuki Suzuki
Masayuki Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP11079188A priority Critical patent/JPH075458B2/en
Publication of JPS6479111A publication Critical patent/JPS6479111A/en
Publication of JPH075458B2 publication Critical patent/JPH075458B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PURPOSE:To obtain a sustained release microcapsule agent containing a drug having high concentration, not swelling by water absorption, by coating a drug- polymer composite material having a crosslinking degree of ion exchange polymer and a drug concentration prescribed in specific ranges with a coating film of water-permeable high polymer. CONSTITUTION:An ion exchange polymer having adsorbed >=80%, especially 85-100% drug based on theoretical ion absorption amount and 6-16%, preferably 8-14% crosslinking degree is coated with a coating film of a water- permeable high polymer (e.g., aminoalkyl methacrylate copolymer). The ion exchanger polymer has 5-1,000mum, especially 10-300mum average particle diameter and a basic drug having 7.5-10pKa or an acidic drug having 2-5pKa is preferable as the drug used. 0.2-10g of the preparation is suspended in 100ml purified water to prepare suspension for oral administration.
JP11079188A 1987-06-02 1988-05-07 Sustained release preparation and method for producing the same Expired - Fee Related JPH075458B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11079188A JPH075458B2 (en) 1987-06-02 1988-05-07 Sustained release preparation and method for producing the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13878187 1987-06-02
JP62-138781 1987-06-02
JP11079188A JPH075458B2 (en) 1987-06-02 1988-05-07 Sustained release preparation and method for producing the same

Publications (2)

Publication Number Publication Date
JPS6479111A true JPS6479111A (en) 1989-03-24
JPH075458B2 JPH075458B2 (en) 1995-01-25

Family

ID=26450321

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11079188A Expired - Fee Related JPH075458B2 (en) 1987-06-02 1988-05-07 Sustained release preparation and method for producing the same

Country Status (1)

Country Link
JP (1) JPH075458B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512327A (en) * 2002-11-26 2006-04-13 ホ−レンベック ギャリ− ア−ル Aqueous sustained-release drug delivery system for highly water-soluble electrolyte drugs
JP2011530491A (en) * 2008-08-08 2011-12-22 ビーエーエスエフ ソシエタス・ヨーロピア Biopolymer-based continuous fiber layers containing active substances, their use, and methods for their production

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512327A (en) * 2002-11-26 2006-04-13 ホ−レンベック ギャリ− ア−ル Aqueous sustained-release drug delivery system for highly water-soluble electrolyte drugs
JP4808405B2 (en) * 2002-11-26 2011-11-02 ホ−レンベック ギャリ− ア−ル Aqueous sustained-release drug delivery system for highly water-soluble electrolyte drugs
JP2011530491A (en) * 2008-08-08 2011-12-22 ビーエーエスエフ ソシエタス・ヨーロピア Biopolymer-based continuous fiber layers containing active substances, their use, and methods for their production

Also Published As

Publication number Publication date
JPH075458B2 (en) 1995-01-25

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees