JPS6475421A - Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester - Google Patents
Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid esterInfo
- Publication number
- JPS6475421A JPS6475421A JP23336187A JP23336187A JPS6475421A JP S6475421 A JPS6475421 A JP S6475421A JP 23336187 A JP23336187 A JP 23336187A JP 23336187 A JP23336187 A JP 23336187A JP S6475421 A JPS6475421 A JP S6475421A
- Authority
- JP
- Japan
- Prior art keywords
- alpha
- compound
- formula
- freeze
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain the titled preparation easily convertible into a drug preparation keeping the active component in stable state and able to be reconstituted to liposome in excellent reconstitution yield, by including an alpha,alpha-trehalose trimycolic acid ester in liposome and freeze-drying the product. CONSTITUTION:(A) A compound of formula (R<1>-R<8> are H or mycolic acid residue provided that three of R<1>-R<8> are mycolic acid residue), preferably a compound of formula wherein R<1>, R<2> and R<8> or R<1>, R<4> and R<8> are mycolic acid residue and (B) a phospholipid or a phospholipid-containing material are dissolved in an organic solvent, the solvent is distilled off from the solution and the residue is dispersed in an aqueous solvent to obtain a liposome containing the compound of formula. The product is freeze-dried by conventional means (e.g. at -20--50 deg.C under vacuum of <=0.1Torr). The compound of formula can be produced by culturing a strain of genus Rhodococcus, especially Rhodococcus aurantiacus (ATCC 25938) and separating the compound of formula accumulated in the bacterial cell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23336187A JPS6475421A (en) | 1987-09-17 | 1987-09-17 | Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23336187A JPS6475421A (en) | 1987-09-17 | 1987-09-17 | Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6475421A true JPS6475421A (en) | 1989-03-22 |
Family
ID=16953945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP23336187A Pending JPS6475421A (en) | 1987-09-17 | 1987-09-17 | Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6475421A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06315623A (en) * | 1993-03-10 | 1994-11-15 | Chiba Seifun Kk | Dry endoplasmic reticulum |
| EP0855179A3 (en) * | 1997-01-16 | 1999-03-24 | Lipotec, S.A. | Pharmaceutical preparation comprising coated capsules or tablets containing a liposome powder encapsulating a drug |
| JP2002531171A (en) * | 1998-12-01 | 2002-09-24 | スリーエム イノベイティブ プロパティズ カンパニー | Adhesive articles for wet skin |
| US6497898B1 (en) | 1993-10-07 | 2002-12-24 | Kanebo Ltd | Surfactant, and an emulsion-type cosmetic composition and a lipsome containing said surfactant |
| CN110195026A (en) * | 2019-03-04 | 2019-09-03 | 暨南大学 | A kind of method that DEHP degradation bacterial agent prepared and its be effectively reduced DEHP pollution in vegetables production |
-
1987
- 1987-09-17 JP JP23336187A patent/JPS6475421A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06315623A (en) * | 1993-03-10 | 1994-11-15 | Chiba Seifun Kk | Dry endoplasmic reticulum |
| US6497898B1 (en) | 1993-10-07 | 2002-12-24 | Kanebo Ltd | Surfactant, and an emulsion-type cosmetic composition and a lipsome containing said surfactant |
| EP0855179A3 (en) * | 1997-01-16 | 1999-03-24 | Lipotec, S.A. | Pharmaceutical preparation comprising coated capsules or tablets containing a liposome powder encapsulating a drug |
| JP2002531171A (en) * | 1998-12-01 | 2002-09-24 | スリーエム イノベイティブ プロパティズ カンパニー | Adhesive articles for wet skin |
| CN110195026A (en) * | 2019-03-04 | 2019-09-03 | 暨南大学 | A kind of method that DEHP degradation bacterial agent prepared and its be effectively reduced DEHP pollution in vegetables production |
| CN110195026B (en) * | 2019-03-04 | 2022-10-11 | 暨南大学 | Preparation of DEHP degrading microbial inoculum and method for effectively reducing DEHP pollution in vegetable production |
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