JPS6475421A - Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester - Google Patents

Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester

Info

Publication number
JPS6475421A
JPS6475421A JP23336187A JP23336187A JPS6475421A JP S6475421 A JPS6475421 A JP S6475421A JP 23336187 A JP23336187 A JP 23336187A JP 23336187 A JP23336187 A JP 23336187A JP S6475421 A JPS6475421 A JP S6475421A
Authority
JP
Japan
Prior art keywords
alpha
compound
formula
freeze
liposome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP23336187A
Other languages
Japanese (ja)
Inventor
Takayoshi Kato
Fusa Yokoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sawai Pharmaceutical Co Ltd
Original Assignee
Sawai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sawai Pharmaceutical Co Ltd filed Critical Sawai Pharmaceutical Co Ltd
Priority to JP23336187A priority Critical patent/JPS6475421A/en
Publication of JPS6475421A publication Critical patent/JPS6475421A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To obtain the titled preparation easily convertible into a drug preparation keeping the active component in stable state and able to be reconstituted to liposome in excellent reconstitution yield, by including an alpha,alpha-trehalose trimycolic acid ester in liposome and freeze-drying the product. CONSTITUTION:(A) A compound of formula (R<1>-R<8> are H or mycolic acid residue provided that three of R<1>-R<8> are mycolic acid residue), preferably a compound of formula wherein R<1>, R<2> and R<8> or R<1>, R<4> and R<8> are mycolic acid residue and (B) a phospholipid or a phospholipid-containing material are dissolved in an organic solvent, the solvent is distilled off from the solution and the residue is dispersed in an aqueous solvent to obtain a liposome containing the compound of formula. The product is freeze-dried by conventional means (e.g. at -20--50 deg.C under vacuum of <=0.1Torr). The compound of formula can be produced by culturing a strain of genus Rhodococcus, especially Rhodococcus aurantiacus (ATCC 25938) and separating the compound of formula accumulated in the bacterial cell.
JP23336187A 1987-09-17 1987-09-17 Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester Pending JPS6475421A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP23336187A JPS6475421A (en) 1987-09-17 1987-09-17 Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23336187A JPS6475421A (en) 1987-09-17 1987-09-17 Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester

Publications (1)

Publication Number Publication Date
JPS6475421A true JPS6475421A (en) 1989-03-22

Family

ID=16953945

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23336187A Pending JPS6475421A (en) 1987-09-17 1987-09-17 Freeze-dried preparation of liposome containing alpha,alpha-trehalose trimycolic acid ester

Country Status (1)

Country Link
JP (1) JPS6475421A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06315623A (en) * 1993-03-10 1994-11-15 Chiba Seifun Kk Dry endoplasmic reticulum
EP0855179A3 (en) * 1997-01-16 1999-03-24 Lipotec, S.A. Pharmaceutical preparation comprising coated capsules or tablets containing a liposome powder encapsulating a drug
JP2002531171A (en) * 1998-12-01 2002-09-24 スリーエム イノベイティブ プロパティズ カンパニー Adhesive articles for wet skin
US6497898B1 (en) 1993-10-07 2002-12-24 Kanebo Ltd Surfactant, and an emulsion-type cosmetic composition and a lipsome containing said surfactant
CN110195026A (en) * 2019-03-04 2019-09-03 暨南大学 A kind of method that DEHP degradation bacterial agent prepared and its be effectively reduced DEHP pollution in vegetables production

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06315623A (en) * 1993-03-10 1994-11-15 Chiba Seifun Kk Dry endoplasmic reticulum
US6497898B1 (en) 1993-10-07 2002-12-24 Kanebo Ltd Surfactant, and an emulsion-type cosmetic composition and a lipsome containing said surfactant
EP0855179A3 (en) * 1997-01-16 1999-03-24 Lipotec, S.A. Pharmaceutical preparation comprising coated capsules or tablets containing a liposome powder encapsulating a drug
JP2002531171A (en) * 1998-12-01 2002-09-24 スリーエム イノベイティブ プロパティズ カンパニー Adhesive articles for wet skin
CN110195026A (en) * 2019-03-04 2019-09-03 暨南大学 A kind of method that DEHP degradation bacterial agent prepared and its be effectively reduced DEHP pollution in vegetables production
CN110195026B (en) * 2019-03-04 2022-10-11 暨南大学 Preparation of DEHP degrading microbial inoculum and method for effectively reducing DEHP pollution in vegetable production

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