JPS6463565A - Production of n-benzyloxycarbonyl-l-aspartic acid - Google Patents

Production of n-benzyloxycarbonyl-l-aspartic acid

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Publication number
JPS6463565A
JPS6463565A JP22049987A JP22049987A JPS6463565A JP S6463565 A JPS6463565 A JP S6463565A JP 22049987 A JP22049987 A JP 22049987A JP 22049987 A JP22049987 A JP 22049987A JP S6463565 A JPS6463565 A JP S6463565A
Authority
JP
Japan
Prior art keywords
asp
aspartic acid
reaction
benzyloxycarbonyl
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP22049987A
Other languages
Japanese (ja)
Other versions
JP2503529B2 (en
Inventor
Tsuneo Harada
Akira Tokuda
Kiyotaka Koyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tosoh Corp
Original Assignee
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tosoh Corp filed Critical Tosoh Corp
Priority to JP22049987A priority Critical patent/JP2503529B2/en
Publication of JPS6463565A publication Critical patent/JPS6463565A/en
Application granted granted Critical
Publication of JP2503529B2 publication Critical patent/JP2503529B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To obtain the title compound of reduced impurities from benzyl chloroformate and L-aspartic acid, by allowing the title compound or its salt to exist beforehand in the reaction system at the start to facilitate the control of the reaction. CONSTITUTION:When N-benzyloxycarbonyl-L-aspartic acid (Z-Asp) is prepared from benzyl chloroformate (Z-Cl) and L-aspartic acid (Asp), Z-Asp or its salt is allowed to exist beforehand in the reaction system at the start of the reaction in an amount of 0.5-50mol.% based on L-Asp, and the reaction mixture is kept at 0-60 deg.C, 9.5-13.5pH to facilitate the reaction control to give Z-Asp of reduced impurities, which is used as a starting substance of alpha-L-aspartyl-L- phenylalanine methyl ester (artificial sweetener).
JP22049987A 1987-09-04 1987-09-04 Process for producing N-benzyloxycarbonyl-L-aspartic acid Expired - Lifetime JP2503529B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP22049987A JP2503529B2 (en) 1987-09-04 1987-09-04 Process for producing N-benzyloxycarbonyl-L-aspartic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22049987A JP2503529B2 (en) 1987-09-04 1987-09-04 Process for producing N-benzyloxycarbonyl-L-aspartic acid

Publications (2)

Publication Number Publication Date
JPS6463565A true JPS6463565A (en) 1989-03-09
JP2503529B2 JP2503529B2 (en) 1996-06-05

Family

ID=16752000

Family Applications (1)

Application Number Title Priority Date Filing Date
JP22049987A Expired - Lifetime JP2503529B2 (en) 1987-09-04 1987-09-04 Process for producing N-benzyloxycarbonyl-L-aspartic acid

Country Status (1)

Country Link
JP (1) JP2503529B2 (en)

Also Published As

Publication number Publication date
JP2503529B2 (en) 1996-06-05

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