JPS6463559A - Peptide analog having resin-inhibiting activity - Google Patents
Peptide analog having resin-inhibiting activityInfo
- Publication number
- JPS6463559A JPS6463559A JP62321778A JP32177887A JPS6463559A JP S6463559 A JPS6463559 A JP S6463559A JP 62321778 A JP62321778 A JP 62321778A JP 32177887 A JP32177887 A JP 32177887A JP S6463559 A JPS6463559 A JP S6463559A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- resin
- phenyl
- formula
- inhibiting activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000011347 resin Substances 0.000 title 1
- 229920005989 resin Polymers 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 230000036454 renin-angiotensin system Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound of formula I [m is 0-2; n is 1-3; R<1> is alkyl, heterocyclyl bound with N, NR<5>R<6> (R<5>, R<6> are alkyl, aralkyl); R<2> is phenyl, naphthyl, cyclohexyl; R<3> is heteroaryl, phenyl, alkyl; R<4> is alkyl which may be substituted (with heterocyclyl, pyridyl, hydroxyl and the like); R<4>' is H, alkyl] and its salts. EXAMPLE:N-[ (2R)-3-Morpholinocarbonyl-2-(1-naphthylmethyl)propionyl ]-(4-thia zolyl)-L-alanyl-cyclostachin-(2-morpholinoethyl)amide. USE:A diagnostic and remedy for hypertension based on the renin-angiotensin system. It is excellent in solubility in water, oral absorption, biological utility and useful in oral administration. PREPARATION:The peptide synthesis according to the reaction route given in the figure gives the peptide of formula I.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30298386 | 1986-12-19 | ||
| JP61-302983 | 1986-12-19 | ||
| JP12706587 | 1987-05-26 | ||
| JP62-127065 | 1987-05-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6463559A true JPS6463559A (en) | 1989-03-09 |
| JPH07116118B2 JPH07116118B2 (en) | 1995-12-13 |
Family
ID=26463104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62321778A Expired - Lifetime JPH07116118B2 (en) | 1986-12-19 | 1987-12-18 | Peptide analog having renin inhibitory activity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07116118B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016497A1 (en) * | 1991-03-22 | 1992-10-01 | Japan Tobacco Inc. | Amino acid derivative having renin inhibitory activity |
| US7367587B2 (en) | 2002-05-10 | 2008-05-06 | Daihatsu Motor Co., Ltd. | Instrument panel structure for vehicles |
-
1987
- 1987-12-18 JP JP62321778A patent/JPH07116118B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016497A1 (en) * | 1991-03-22 | 1992-10-01 | Japan Tobacco Inc. | Amino acid derivative having renin inhibitory activity |
| US7367587B2 (en) | 2002-05-10 | 2008-05-06 | Daihatsu Motor Co., Ltd. | Instrument panel structure for vehicles |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07116118B2 (en) | 1995-12-13 |
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