JPS6461500A - Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp - Google Patents

Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp

Info

Publication number
JPS6461500A
JPS6461500A JP62218662A JP21866287A JPS6461500A JP S6461500 A JPS6461500 A JP S6461500A JP 62218662 A JP62218662 A JP 62218662A JP 21866287 A JP21866287 A JP 21866287A JP S6461500 A JPS6461500 A JP S6461500A
Authority
JP
Japan
Prior art keywords
hanp
alpha
monoclonal antibody
measuring reagent
immunologically measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62218662A
Other languages
Japanese (ja)
Other versions
JPH0570436B2 (en
Inventor
Hiroo Imura
Ichikazu Nakao
Eiji Ishikawa
Masao Kono
Takeshi Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP62218662A priority Critical patent/JPS6461500A/en
Priority to CA000575613A priority patent/CA1335082C/en
Priority to NO883854A priority patent/NO174005C/en
Priority to DK198804845A priority patent/DK174151B1/en
Priority to ES88308100T priority patent/ES2061664T3/en
Priority to AT88308100T priority patent/ATE97959T1/en
Priority to DE88308100T priority patent/DE3885975T2/en
Priority to EP19880308100 priority patent/EP0306309B1/en
Priority to KR1019880011311A priority patent/KR940009281B1/en
Publication of JPS6461500A publication Critical patent/JPS6461500A/en
Priority to JP5106135A priority patent/JPH0753105B2/en
Publication of JPH0570436B2 publication Critical patent/JPH0570436B2/ja
Priority to HK98102977A priority patent/HK1003795A1/en
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

NEW MATERIAL:A monoclonal antibody to recognize approximately half at the N end side of a ring structure of human-atrial sodium natriuretic polypeptide (alpha-hANP). USE:An immunologically measuring reagent for alpha-hANP. PREPARATION:For example, alpha-hANP is bonded to bovine serum albumin by using a binder, emulsified in a proper adjuvant and administered to an abdominal cavity of a mouse to immunize the mouse. The third day after final immunization, a splenocyte is collected, fused with a myeloma cell strain and a hybridoma is obtained by HAT selection method. Then a clone to produce an antibody having reactivity to alpha-hANP is selected from the hybridoma, cloned by limiting dilution method into a monoclone and further cultivated to give a monoclonal antibody.
JP62218662A 1987-09-01 1987-09-01 Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp Granted JPS6461500A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP62218662A JPS6461500A (en) 1987-09-01 1987-09-01 Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp
CA000575613A CA1335082C (en) 1987-09-01 1988-08-24 Monoclonal antibody recognizing –-hanp and a reagent for immunoassay of –-hanp
NO883854A NO174005C (en) 1987-09-01 1988-08-30 Monoclonal antibody, hybridoma, and reagent for immunological analysis of x-hANP
DK198804845A DK174151B1 (en) 1987-09-01 1988-08-31 Monoclonal antibody, hybridoma and reagent for immunoassay of alpha-hANP
AT88308100T ATE97959T1 (en) 1987-09-01 1988-09-01 MONOCLONAL ANTIBODIES TO HUMAN APHAATRIALNATRI¨RETIC POLYPEPTIDES AND CORRESPONDING HYBRIDOMES, THEIR PRODUCTION AND USE.
ES88308100T ES2061664T3 (en) 1987-09-01 1988-09-01 MONOCLONAL ANTIBODIES RECOGNIZING ALFA-HANP AND CORRESPONDING HYBRIDOMES, THEIR PREPARATION AND USE.
DE88308100T DE3885975T2 (en) 1987-09-01 1988-09-01 Monoclonal antibodies against human alpha-Atrialnatriüretic polypeptides and corresponding hybridomas, their production and use.
EP19880308100 EP0306309B1 (en) 1987-09-01 1988-09-01 Monoclonal antibodies recognizing alpha-hANP and corresponding hybridomas, their preparation and use
KR1019880011311A KR940009281B1 (en) 1987-09-01 1988-09-01 Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp
JP5106135A JPH0753105B2 (en) 1987-09-01 1993-04-07 A hybridoma producing a monoclonal antibody that recognizes α-hANP
HK98102977A HK1003795A1 (en) 1987-09-01 1998-04-09 Monoclonal antibodies recognizing alpha-hanp and corresponding hybridomas their preparation and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62218662A JPS6461500A (en) 1987-09-01 1987-09-01 Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp
JP5106135A JPH0753105B2 (en) 1987-09-01 1993-04-07 A hybridoma producing a monoclonal antibody that recognizes α-hANP

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP5106135A Division JPH0753105B2 (en) 1987-09-01 1993-04-07 A hybridoma producing a monoclonal antibody that recognizes α-hANP

Publications (2)

Publication Number Publication Date
JPS6461500A true JPS6461500A (en) 1989-03-08
JPH0570436B2 JPH0570436B2 (en) 1993-10-05

Family

ID=26446305

Family Applications (2)

Application Number Title Priority Date Filing Date
JP62218662A Granted JPS6461500A (en) 1987-09-01 1987-09-01 Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp
JP5106135A Expired - Lifetime JPH0753105B2 (en) 1987-09-01 1993-04-07 A hybridoma producing a monoclonal antibody that recognizes α-hANP

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP5106135A Expired - Lifetime JPH0753105B2 (en) 1987-09-01 1993-04-07 A hybridoma producing a monoclonal antibody that recognizes α-hANP

Country Status (1)

Country Link
JP (2) JPS6461500A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02276591A (en) * 1989-04-19 1990-11-13 Shionogi & Co Ltd Monoclonal antibody recognizing c end side of anp
JPH034169A (en) * 1989-05-31 1991-01-10 Green Cross Corp:The Mehtod for immunoassay of hanp antibody and hanp
JP2016079146A (en) * 2014-10-21 2016-05-16 東ソー株式会社 SPECIFIC METHOD FOR MEASUREMENT OF β-ANP
JP2016180665A (en) * 2015-03-24 2016-10-13 東ソー株式会社 METHOD FOR DETECTING CARDIAC FAILURE WITH β-ANP

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2403533A (en) * 2003-06-30 2005-01-05 Orion Corp Atrial natriuretic peptide and brain natriuretic peptide and assays and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62294094A (en) * 1986-06-12 1987-12-21 Sanaka Tsutomu Monoclonal antibody

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62294094A (en) * 1986-06-12 1987-12-21 Sanaka Tsutomu Monoclonal antibody

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02276591A (en) * 1989-04-19 1990-11-13 Shionogi & Co Ltd Monoclonal antibody recognizing c end side of anp
JPH034169A (en) * 1989-05-31 1991-01-10 Green Cross Corp:The Mehtod for immunoassay of hanp antibody and hanp
JP2016079146A (en) * 2014-10-21 2016-05-16 東ソー株式会社 SPECIFIC METHOD FOR MEASUREMENT OF β-ANP
JP2016180665A (en) * 2015-03-24 2016-10-13 東ソー株式会社 METHOD FOR DETECTING CARDIAC FAILURE WITH β-ANP

Also Published As

Publication number Publication date
JPH0570436B2 (en) 1993-10-05
JPH0678763A (en) 1994-03-22
JPH0753105B2 (en) 1995-06-07

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