JPS6461481A - Porphyrin derivative - Google Patents

Porphyrin derivative

Info

Publication number
JPS6461481A
JPS6461481A JP62216534A JP21653487A JPS6461481A JP S6461481 A JPS6461481 A JP S6461481A JP 62216534 A JP62216534 A JP 62216534A JP 21653487 A JP21653487 A JP 21653487A JP S6461481 A JPS6461481 A JP S6461481A
Authority
JP
Japan
Prior art keywords
amino acid
iodine
gamma
cancer
dotted line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62216534A
Other languages
Japanese (ja)
Inventor
Isao Sakata
Susumu Nakajima
Koichi Koshimizu
Natsuki Samejima
Hiroyuki Takada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Hakka Kogyo Co Ltd
Original Assignee
Toyo Hakka Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Hakka Kogyo Co Ltd filed Critical Toyo Hakka Kogyo Co Ltd
Priority to JP62216534A priority Critical patent/JPS6461481A/en
Publication of JPS6461481A publication Critical patent/JPS6461481A/en
Pending legal-status Critical Current

Links

Landscapes

  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by the formula [R1 and R2 represent -CH=CH2, -CH2CH3, etc.; R3 represents H, COOH, -COR (R represents OH or residue formed by eliminating H from an amino-acid), etc.; R4 represents OH or R; A represents CH2- or -CO-; dotted line bonded to the gamma-position represents no-binding or single bond; dotted line between the gamma-position and the 8-position represents single bond or double bond] and metal complex thereof (provided that the metal complex is in a porphyrin skeleton, and at least one of R3 and R4 represents group having R which represents tyrosine, fluorine- containing amino acid or iodine-containing amino acid residue). EXAMPLE:2,4-Bis[1-(2-hydroxyethyloxy)ethyl]-Ga-deuteroporphyrinyl dityrosine. USE:A cancer-directing medical preparation used for treatment, diagnosis, marker and misile-targeting therapeia of cancer. PREPARATION:A porphyrin compound corresponding to the formula wherein R is OH is formed and an amino acid residue is introduced thereto. Iodine, as necessary, is bonded.
JP62216534A 1987-09-01 1987-09-01 Porphyrin derivative Pending JPS6461481A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62216534A JPS6461481A (en) 1987-09-01 1987-09-01 Porphyrin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62216534A JPS6461481A (en) 1987-09-01 1987-09-01 Porphyrin derivative

Publications (1)

Publication Number Publication Date
JPS6461481A true JPS6461481A (en) 1989-03-08

Family

ID=16689943

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62216534A Pending JPS6461481A (en) 1987-09-01 1987-09-01 Porphyrin derivative

Country Status (1)

Country Link
JP (1) JPS6461481A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492924A (en) * 1993-09-24 1996-02-20 Fox Chase Cancer Center Phorbine derivatives and their use in the diagnosis and therapy of cancer
KR100484206B1 (en) * 2003-01-16 2005-04-20 주식회사 테크노마트 Porphyrin derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492924A (en) * 1993-09-24 1996-02-20 Fox Chase Cancer Center Phorbine derivatives and their use in the diagnosis and therapy of cancer
KR100484206B1 (en) * 2003-01-16 2005-04-20 주식회사 테크노마트 Porphyrin derivatives

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