JPS6456618A - Sustained release steroidal rectal administration pharmaceutical - Google Patents

Sustained release steroidal rectal administration pharmaceutical

Info

Publication number
JPS6456618A
JPS6456618A JP21428087A JP21428087A JPS6456618A JP S6456618 A JPS6456618 A JP S6456618A JP 21428087 A JP21428087 A JP 21428087A JP 21428087 A JP21428087 A JP 21428087A JP S6456618 A JPS6456618 A JP S6456618A
Authority
JP
Japan
Prior art keywords
fatty
rectal administration
oily base
blending
prednisolone acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP21428087A
Other languages
Japanese (ja)
Inventor
Kazusane Takayanagi
Yasuhisa Okuyama
Chikako Kiyohara
Nobuo Kawabata
Shuichi Kasai
Akira Iwasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SSP Co Ltd
Original Assignee
SSP Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SSP Co Ltd filed Critical SSP Co Ltd
Priority to JP21428087A priority Critical patent/JPS6456618A/en
Publication of JPS6456618A publication Critical patent/JPS6456618A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To obtain the titled readily producible pharmaceutical, having a delayed elution rate of an active ingredient and long duration of sustained blood level without any side effects, by blending a fatty and oily base with prednisolone acetate which is a synthetic adrenocortical hormone having anti- inflammatory action. CONSTITUTION:A sustained release steroidal rectal administration pharmaceutical obtained by blending a fatty and oily base selected from the group consisting of animal and vegetable fats and oils, mineral oils and glycerol esters of fatty acids with prednisolone acetate. The amount thereof blended is preferably within the range of 0.1-20wt.%, especially 0.2-10wt.% in the rectal administration pharmaceutical, which is prepared by blending and dispersing the prednisolone acetate with the fatty and oily base according to a conventional method and forming a solid suppository having 30-37 deg.C melting point or filling the blend or dispersion in an injection type rectal administration tube. Furthermore, the aforementioned fatty and oily base is preferably a solid at ordinary temperature and has 26-37 deg.C, especially 30-37 deg.C melting point.
JP21428087A 1987-08-28 1987-08-28 Sustained release steroidal rectal administration pharmaceutical Pending JPS6456618A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP21428087A JPS6456618A (en) 1987-08-28 1987-08-28 Sustained release steroidal rectal administration pharmaceutical

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21428087A JPS6456618A (en) 1987-08-28 1987-08-28 Sustained release steroidal rectal administration pharmaceutical

Publications (1)

Publication Number Publication Date
JPS6456618A true JPS6456618A (en) 1989-03-03

Family

ID=16653117

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21428087A Pending JPS6456618A (en) 1987-08-28 1987-08-28 Sustained release steroidal rectal administration pharmaceutical

Country Status (1)

Country Link
JP (1) JPS6456618A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511310A1 (en) * 1990-01-17 1992-11-04 STULTS, Jerry F Non-aqueous emulsion of silicone oil and stearine
JPH04346916A (en) * 1991-05-24 1992-12-02 Iwaki Seiyaku Kk Base for suppository

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511310A1 (en) * 1990-01-17 1992-11-04 STULTS, Jerry F Non-aqueous emulsion of silicone oil and stearine
JPH04346916A (en) * 1991-05-24 1992-12-02 Iwaki Seiyaku Kk Base for suppository

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