JPS6447714A - Liposome-forming agent - Google Patents

Liposome-forming agent

Info

Publication number
JPS6447714A
JPS6447714A JP20604887A JP20604887A JPS6447714A JP S6447714 A JPS6447714 A JP S6447714A JP 20604887 A JP20604887 A JP 20604887A JP 20604887 A JP20604887 A JP 20604887A JP S6447714 A JPS6447714 A JP S6447714A
Authority
JP
Japan
Prior art keywords
liposome
forming agent
hydroxyalkylalkylmethyl
stirring
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP20604887A
Other languages
Japanese (ja)
Inventor
Kazuyuki Tsubone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP20604887A priority Critical patent/JPS6447714A/en
Publication of JPS6447714A publication Critical patent/JPS6447714A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE:To obtain a liposome-forming agent, containing a 2-(2- hydroxyalkylalkylmethyl)ethylammonium phosphate, compatible with living bodies, having high safety, undecomposable with heat and light and useful for treating congenital deficiency, such as enzyme or vitamin. CONSTITUTION:A liposome-forming agent containing a 2-(2- hydroxyalkylalkylmethyl)ethylammonium phosphate expressed by formula I (R is 8-20C alkyl; R' is 10-22C alkyl) as an active ingredient. The titled liposome-forming agent is obtained by, e.g. dissolving a 2-(2- hydroxyalkylalkylmethyl)ethanol halide expressed by formula II (X is Cl, Br, I or F) in benzene (1-40wt.% concentration), adding phosphorus oxychloride in a molar amount of 1-3 times to the resultant solution at ambient temperature while stirring, continuing the stirring for 2-30hr, removing the solvent, carrying out stirring using water as the solvent, adjusting pH to 6.0 with a base after the reaction to remove water and desalting the resultant substance.
JP20604887A 1987-08-19 1987-08-19 Liposome-forming agent Pending JPS6447714A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP20604887A JPS6447714A (en) 1987-08-19 1987-08-19 Liposome-forming agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20604887A JPS6447714A (en) 1987-08-19 1987-08-19 Liposome-forming agent

Publications (1)

Publication Number Publication Date
JPS6447714A true JPS6447714A (en) 1989-02-22

Family

ID=16517015

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20604887A Pending JPS6447714A (en) 1987-08-19 1987-08-19 Liposome-forming agent

Country Status (1)

Country Link
JP (1) JPS6447714A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0853220A2 (en) 1997-01-10 1998-07-15 Honda Giken Kogyo Kabushiki Kaisha Absorption refrigerating/heating apparatus
US5901567A (en) * 1996-12-18 1999-05-11 Honda Giken Kogyo Kabushiki Kaisha Absorption refrigerating/heating apparatus
CN112339467A (en) * 2021-01-07 2021-02-09 虎丘影像（苏州）有限公司 Fluorine-containing thermosensitive dye microcapsule, preparation method thereof and film

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5901567A (en) * 1996-12-18 1999-05-11 Honda Giken Kogyo Kabushiki Kaisha Absorption refrigerating/heating apparatus
EP0853220A2 (en) 1997-01-10 1998-07-15 Honda Giken Kogyo Kabushiki Kaisha Absorption refrigerating/heating apparatus
US5941089A (en) * 1997-01-10 1999-08-24 Honda Giken Kogyo Kabushiki Kaisha Absorption refrigerating/heating apparatus
CN112339467A (en) * 2021-01-07 2021-02-09 虎丘影像（苏州）有限公司 Fluorine-containing thermosensitive dye microcapsule, preparation method thereof and film

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