JPS6445360A - 1-benzyl-4-hydroxy-2-pyrrolidone derivative and production thereof - Google Patents

1-benzyl-4-hydroxy-2-pyrrolidone derivative and production thereof

Info

Publication number
JPS6445360A
JPS6445360A JP20082387A JP20082387A JPS6445360A JP S6445360 A JPS6445360 A JP S6445360A JP 20082387 A JP20082387 A JP 20082387A JP 20082387 A JP20082387 A JP 20082387A JP S6445360 A JPS6445360 A JP S6445360A
Authority
JP
Japan
Prior art keywords
benzyl
hydroxy
derivative
formula
pyrrolidone derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP20082387A
Other languages
Japanese (ja)
Inventor
Shinobu Iriuchijima
Takahito Masuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo KK filed Critical Denki Kagaku Kogyo KK
Priority to JP20082387A priority Critical patent/JPS6445360A/en
Publication of JPS6445360A publication Critical patent/JPS6445360A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

NEW MATERIAL:A 1-benzyl-4-hydroxy-2-pyrrolidone derivative of formula I (Ar is phenyl or substituted phenyl). USE:A raw material for a 1-benzyl-3-hydroxypyrrolidine derivative having pharmacological effects of e.g. increasing coronary blood flow rate. PREPARATION:The objective benzyl-4-hydroxy-2-pyrrolidone derivative of formula I can be produced by reacting an alkyl 4-halo-3-hydroxybutyrate or alkyl 3,4-epoxybutyrate with a benzylamine derivative of formula II.
JP20082387A 1987-08-13 1987-08-13 1-benzyl-4-hydroxy-2-pyrrolidone derivative and production thereof Pending JPS6445360A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP20082387A JPS6445360A (en) 1987-08-13 1987-08-13 1-benzyl-4-hydroxy-2-pyrrolidone derivative and production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20082387A JPS6445360A (en) 1987-08-13 1987-08-13 1-benzyl-4-hydroxy-2-pyrrolidone derivative and production thereof

Publications (1)

Publication Number Publication Date
JPS6445360A true JPS6445360A (en) 1989-02-17

Family

ID=16430799

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20082387A Pending JPS6445360A (en) 1987-08-13 1987-08-13 1-benzyl-4-hydroxy-2-pyrrolidone derivative and production thereof

Country Status (1)

Country Link
JP (1) JPS6445360A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0692471A1 (en) 1994-07-15 1996-01-17 Degussa Aktiengesellschaft Process for the preparation of optically active 3-hydroxypyrrolidine derivatives with high optical purity
WO2003091242A1 (en) * 2002-04-26 2003-11-06 Takeda Pharmaceutical Company Limited Novel thiol derivative, process for producing the same and use thereof
KR100711938B1 (en) * 2005-08-29 2007-05-02 한국화학연구원 Method for preparing stereoselective 4-hydroxy-2-pyrrolidinone

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0692471A1 (en) 1994-07-15 1996-01-17 Degussa Aktiengesellschaft Process for the preparation of optically active 3-hydroxypyrrolidine derivatives with high optical purity
WO2003091242A1 (en) * 2002-04-26 2003-11-06 Takeda Pharmaceutical Company Limited Novel thiol derivative, process for producing the same and use thereof
KR100711938B1 (en) * 2005-08-29 2007-05-02 한국화학연구원 Method for preparing stereoselective 4-hydroxy-2-pyrrolidinone

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