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Toray Industries Inc
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Toray Industries Inc
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Application filed by Toray Industries IncfiledCriticalToray Industries Inc
Priority to JP20212587ApriorityCriticalpatent/JPS6445349A/en
Publication of JPS6445349ApublicationCriticalpatent/JPS6445349A/en
PURPOSE:To obtain DL-lysine useful as a basic salt-forming agent for an acidic drug such as aspirin, with economical means in high purity, by racemizing an optically active lysine and treating with a free acid. CONSTITUTION:1mol. (2 equivalent) of an optically active lysine is racemized at 130-200 deg.C by using 0.4-5 times weight of water in the presence of 1-2 equivalent of an acid (e.g. hydrochloric acid). To improve the quality of the product, the racemization reaction liquid is added with 2.1-3 equivalent [based on 1mol. (2 equivalent) of lysine] of an acid (e.g. hydrochloric acid) and treated with the acid at 120-180 deg.C. If necessary, the reaction product is subjected to activated carbon treatment for removing coloring impurities, ion exchange treatment to remove the acid and obtain free DL-lysine, etc.
JP20212587A1987-08-131987-08-13Production of dl-lysine
PendingJPS6445349A
(en)