JPS6442448A - Novel lignan - Google Patents
Novel lignanInfo
- Publication number
- JPS6442448A JPS6442448A JP19819587A JP19819587A JPS6442448A JP S6442448 A JPS6442448 A JP S6442448A JP 19819587 A JP19819587 A JP 19819587A JP 19819587 A JP19819587 A JP 19819587A JP S6442448 A JPS6442448 A JP S6442448A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound expressed
- expressed
- lignan
- hakugomishi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A lignan expressed by formula I (R1 and R2 are OH or together form methylenedioxyl; R3-R5 are OH or OCH3; R6 and R7 are H or OH). EXAMPLE:(+)-(6S,7S,R-biar)-5,6,7,8-Tetrahydro-1,3,12-trimethoxy-10,11- methylene dioxy-6,7-dimethyl-2,6-dibenzo[a,c]cyclooctenediol. USE:A medicine and remedy for inflammatory diseases capable of exhibiting inhibitory action of 5-lipoxygenase. PREPARATION:For example, HAKUGOMISHI (dried fruit of Schizandra chinensis Baill.) is extracted with lower hydrocarbons while warm and the solvents are then distilled away to provide a residue, which is subsequently dissolved in water, subjected to steam distillation and column chromatography using silica gel and developed with a solvent, such as n-hexane, to afford a compound expressed by formula II. The resultant compound expressed by formu la II is used as a raw material, incubated by adding a hepatic homogenate, reacted, separated and purified while confirming the compound expressed by formula I by thin layer chromatography to provide the aimed compound expressed by formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19819587A JPS6442448A (en) | 1987-08-10 | 1987-08-10 | Novel lignan |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19819587A JPS6442448A (en) | 1987-08-10 | 1987-08-10 | Novel lignan |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6442448A true JPS6442448A (en) | 1989-02-14 |
Family
ID=16387052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP19819587A Pending JPS6442448A (en) | 1987-08-10 | 1987-08-10 | Novel lignan |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6442448A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61282315A (en) * | 1985-06-07 | 1986-12-12 | Tsumura Juntendo Inc | Remedy for hepatic insufficiency |
-
1987
- 1987-08-10 JP JP19819587A patent/JPS6442448A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61282315A (en) * | 1985-06-07 | 1986-12-12 | Tsumura Juntendo Inc | Remedy for hepatic insufficiency |
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