JPS6442424A - Ophthalmic solution - Google Patents
Ophthalmic solutionInfo
- Publication number
- JPS6442424A JPS6442424A JP62198877A JP19887787A JPS6442424A JP S6442424 A JPS6442424 A JP S6442424A JP 62198877 A JP62198877 A JP 62198877A JP 19887787 A JP19887787 A JP 19887787A JP S6442424 A JPS6442424 A JP S6442424A
- Authority
- JP
- Japan
- Prior art keywords
- taurin
- solution
- eye
- injury
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002997 ophthalmic solution Substances 0.000 title abstract 2
- 229940054534 ophthalmic solution Drugs 0.000 title abstract 2
- RSDQBPGKMDFRHH-MJVIGCOGSA-N (3s,3as,5ar,9bs)-3,5a,9-trimethyl-3a,4,5,7,8,9b-hexahydro-3h-benzo[g][1]benzofuran-2,6-dione Chemical compound O=C([C@]1(C)CC2)CCC(C)=C1[C@@H]1[C@@H]2[C@H](C)C(=O)O1 RSDQBPGKMDFRHH-MJVIGCOGSA-N 0.000 abstract 4
- RSDQBPGKMDFRHH-UHFFFAOYSA-N Taurin Natural products C1CC2(C)C(=O)CCC(C)=C2C2C1C(C)C(=O)O2 RSDQBPGKMDFRHH-UHFFFAOYSA-N 0.000 abstract 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 239000000645 desinfectant Substances 0.000 abstract 2
- 239000003889 eye drop Substances 0.000 abstract 2
- 208000014674 injury Diseases 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 abstract 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
- 229930003268 Vitamin C Natural products 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229960003720 enoxolone Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- -1 glycyrrhetic acid dipotassium salt Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 239000007951 isotonicity adjuster Substances 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- OSZNNLWOYWAHSS-UHFFFAOYSA-M neostigmine methyl sulfate Chemical compound COS([O-])(=O)=O.CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 OSZNNLWOYWAHSS-UHFFFAOYSA-M 0.000 abstract 1
- 229960002253 neostigmine methylsulfate Drugs 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 230000009182 swimming Effects 0.000 abstract 1
- 235000019154 vitamin C Nutrition 0.000 abstract 1
- 239000011718 vitamin C Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Abstract
PURPOSE:To obtain a safe ophthalmic solution effective in treating the injury of ophthalmic tissue caused by a chlorine-based disinfectant in a pool during swimming, by compounding a specific amount of taurin. CONSTITUTION:Taurin is compounded in an amount of 2.5-3.5W/V%. The addition of taurin solves various problems of eye drops of acetylcysteine or vitamin C for the treatment of the injury of opthalmic tissue caused by chlorine- based disinfectant, e.g. instability in an aqueous solution to unable long-term preservation and disagreeable irritation when applied to eye. The opthalmic solution is used in the form of eye drop or face wash and can be produced by dissolving a prescribed amount of taurin together with other drugs (e.g. neostigmine methyl sulfate or glycyrrhetic acid dipotassium salt), a preservative (e.g. p-oxybenzoic acid esters), a buffering agent (e.g. boric acid), an isotonic agent (e.g. NaCl), etc., in 70-90% of sterilized and purified water (based on the whole solution) under heating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62198877A JPH0641409B2 (en) | 1987-08-08 | 1987-08-08 | Ophthalmic solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62198877A JPH0641409B2 (en) | 1987-08-08 | 1987-08-08 | Ophthalmic solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6442424A true JPS6442424A (en) | 1989-02-14 |
| JPH0641409B2 JPH0641409B2 (en) | 1994-06-01 |
Family
ID=16398408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62198877A Expired - Lifetime JPH0641409B2 (en) | 1987-08-08 | 1987-08-08 | Ophthalmic solution |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0641409B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996008244A1 (en) * | 1994-09-14 | 1996-03-21 | Taisho Pharmaceutical Co., Ltd. | Eye drops for repairing corneal disturbance |
| WO1996019211A1 (en) * | 1994-12-19 | 1996-06-27 | Taisho Pharmaceutical Co., Ltd. | Liposome eye drops |
| JP2006511577A (en) * | 2002-12-23 | 2006-04-06 | アドバンスト メディカル オプティクス， インコーポレーテッド | CONTACT LENS CARE COMPOSITION, METHOD OF USE THEREOF, AND PREPARATION PROTECTING THE INTEGRITY OF EYE TISSUE-CELL MEMBRANE |
| US8276257B2 (en) | 2004-07-30 | 2012-10-02 | Hitachi Global Storage Technologies Netherlands B.V. | Method for making coplanar write head pole tips |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007302736A (en) * | 2006-05-09 | 2007-11-22 | Kawaken Fine Chem Co Ltd | Chlorine scavenger and chemical agent containing the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52108015A (en) * | 1976-03-08 | 1977-09-10 | Santen Pharmaceutical Co Ltd | Low concentrated pyrokalpine eyewash solution |
| JPS6333327A (en) * | 1986-07-28 | 1988-02-13 | Lion Corp | Stabilized phenylephrine liquid agent |
-
1987
- 1987-08-08 JP JP62198877A patent/JPH0641409B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52108015A (en) * | 1976-03-08 | 1977-09-10 | Santen Pharmaceutical Co Ltd | Low concentrated pyrokalpine eyewash solution |
| JPS6333327A (en) * | 1986-07-28 | 1988-02-13 | Lion Corp | Stabilized phenylephrine liquid agent |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996008244A1 (en) * | 1994-09-14 | 1996-03-21 | Taisho Pharmaceutical Co., Ltd. | Eye drops for repairing corneal disturbance |
| WO1996019211A1 (en) * | 1994-12-19 | 1996-06-27 | Taisho Pharmaceutical Co., Ltd. | Liposome eye drops |
| JP2006511577A (en) * | 2002-12-23 | 2006-04-06 | アドバンスト メディカル オプティクス， インコーポレーテッド | CONTACT LENS CARE COMPOSITION, METHOD OF USE THEREOF, AND PREPARATION PROTECTING THE INTEGRITY OF EYE TISSUE-CELL MEMBRANE |
| US8276257B2 (en) | 2004-07-30 | 2012-10-02 | Hitachi Global Storage Technologies Netherlands B.V. | Method for making coplanar write head pole tips |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0641409B2 (en) | 1994-06-01 |
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