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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Application filed by Ajinomoto Co IncfiledCriticalAjinomoto Co Inc
Priority to JP19418487ApriorityCriticalpatent/JPH0813845B2/en
Publication of JPS6438401ApublicationCriticalpatent/JPS6438401A/en
Publication of JPH0813845B2publicationCriticalpatent/JPH0813845B2/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Polysaccharides And Polysaccharide Derivatives
(AREA)
Abstract
PURPOSE:To obtain the title derivative which is excellent in antitumorous activity and water-solubility and useful for anticancerous agents etc., by bonding at least one compd. selected from among D-xylose, D-ribose and their derivatives to the side chains of a glucan. CONSTITUTION:A glucan having an MW of at least 10,000, such as beta-1,3-glucan, cellulose, etc., is heated under reflux with at least one member selected from among orthoesters of D-xylopyranose of formula I and II, D-xylose, D-ribose and their oligomers, such as orthoesters of D-ribose, of formulas III and IV, to effect condensation of the glucan with the hydroxyl groups of the orthoesters, and the product is, if necessary, de-esterified to convert it into a water-soluble polysaccharide, which is purified by dialysis, freeze-dried and isolated to give the title derivative having a structure wherein at least one member of D-xylose, D-ribose and their oligomers are bonded to the side chains of the glucan at a degree of branching of 5-60 per 100 glucan constituting sugars.
Structure and anticoagulant activity of sulfated fucans: comparison between the regular, repetitive, and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae
Analysis of N‐acetyl‐4‐O‐acetylneuraminic‐acid‐containing. N‐linked carbohydrate chains released by peptide‐N4‐(N‐acetyl‐β‐glucosaminyl) asparagine amidase F: Application to the structure determination of the carbohydrate chains of equine fibrinogen