JPS6431766A - Thrombocyte promoter antagonistic compound - Google Patents
Thrombocyte promoter antagonistic compoundInfo
- Publication number
- JPS6431766A JPS6431766A JP63171720A JP17172088A JPS6431766A JP S6431766 A JPS6431766 A JP S6431766A JP 63171720 A JP63171720 A JP 63171720A JP 17172088 A JP17172088 A JP 17172088A JP S6431766 A JPS6431766 A JP S6431766A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- aryl
- hydrogen
- independently
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Compounds of the formula <IMAGE> I Y is O ir S, *A is paraphenylene or *--(CH2)n--(X)m-(CH2)r--, X is O, S or -CH=CH-, n or r, independently, are integers from 0 to 3, s is an integer from 0 to 1, m is an integer from 0 to 1, provided that when m is 1, n+s must be at least 2, R1 and R2, independently, are hydrogen, lower alkyl, cycloalkyl, lower alkenyl, Het, aryl, R3, R4 and R8, independently, are hydrogen, lower alkyl, aryl, R5 and R6, independently, are hydrogen or lower alkyl, R7 is hydrogen, lower alkyl, cycloalkyl, Het-lower alkyl or aryl, Het is a monocyclic 5- or 6-membered hetero aromatic or a bicyclic heteroaromatic radical containing one or two hetero atoms selected from nitrogen, oxygen and sulfur, which radical may be substituted by lower alkyl, halogen or aryl, and the asterisk denotes the point of attachment, and when R6 and R7 are different, their enantiomers and racemic mixtures thereof, when R1 and R2 are different, their geometric isomers, and pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I exhibit activity as platelet activating factor (PAF) antagonists and are, therefore, useful in disease states characerized by excess platelet activating factor or for the prevention and treatment of cardiovascular disease, pulmonary diseases, immunological disorders, inflammatory diseases, dermatological disorders, shock or transplant rejection.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/072,389 US4788206A (en) | 1987-07-10 | 1987-07-10 | Pentadieneamides |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6431766A true JPS6431766A (en) | 1989-02-02 |
Family
ID=22107243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63171720A Pending JPS6431766A (en) | 1987-07-10 | 1988-07-10 | Thrombocyte promoter antagonistic compound |
Country Status (21)
Country | Link |
---|---|
US (1) | US4788206A (en) |
EP (1) | EP0299379B1 (en) |
JP (1) | JPS6431766A (en) |
KR (1) | KR890001989A (en) |
AT (1) | ATE88466T1 (en) |
AU (1) | AU626526B2 (en) |
CZ (1) | CZ394991A3 (en) |
DE (1) | DE3880387D1 (en) |
DK (1) | DK378188A (en) |
ES (1) | ES2054740T3 (en) |
FI (1) | FI883290A (en) |
HU (1) | HU205902B (en) |
IL (1) | IL87017A0 (en) |
MC (1) | MC1954A1 (en) |
MX (1) | MX9203599A (en) |
NO (1) | NO883084L (en) |
NZ (1) | NZ225327A (en) |
PH (1) | PH24605A (en) |
PT (1) | PT87953B (en) |
YU (1) | YU46716B (en) |
ZA (1) | ZA884857B (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997043241A1 (en) * | 1996-05-13 | 1997-11-20 | Nippon Shinyaku Co., Ltd. | Substituted ethylene compounds and drugs |
JP2006505494A (en) * | 2002-02-20 | 2006-02-16 | アボット・ラボラトリーズ | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptors |
JP2006519874A (en) * | 2003-03-05 | 2006-08-31 | セルジーン・コーポレーション | Diphenylethylene compounds and uses thereof |
WO2008007780A1 (en) * | 2006-07-13 | 2008-01-17 | Kyowa Hakko Kirin Co., Ltd. | Pentadienamide derivative |
JP2008247903A (en) * | 1996-04-23 | 2008-10-16 | Targacept Inc | Pharmaceutical formulation for preventing and treating central nervous system disorder |
US7767705B2 (en) | 2006-08-25 | 2010-08-03 | Abbott Laboratories | Compounds that inhibit TRPV1 and uses thereof |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ225307A (en) * | 1987-07-10 | 1991-06-25 | Hoffmann La Roche | Heterocyclic containing alkene derivatives and pharmaceutical compositions |
US5192766A (en) * | 1989-04-28 | 1993-03-09 | Sankyo Company, Limited | N-acryloylpiperazine derivatives, their preparation and their use as PAF antagonists |
US5369106A (en) * | 1989-04-28 | 1994-11-29 | Sankyo Company, Limited | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists |
KR100568997B1 (en) * | 1996-04-23 | 2006-12-15 | 타가셉트 인코포레이티드 | Pharmaceutical Compositions for the Prevention and Treatment of CNS Diseases |
JP2001525400A (en) * | 1997-12-11 | 2001-12-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Retinoic acid pseudoanilide |
US6232316B1 (en) | 1998-06-16 | 2001-05-15 | Targacept, Inc. | Methods for treatment of CNS disorders |
DE19828463A1 (en) * | 1998-06-26 | 1999-12-30 | Basf Ag | 4,4-Diarylbutadienes as water-soluble, photostable UV filters for cosmetic and pharmaceutical preparations |
US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
WO2000075110A1 (en) * | 1999-06-07 | 2000-12-14 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US7772271B2 (en) * | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
BRPI0511834A (en) * | 2004-07-14 | 2008-01-08 | Ptc Therapeutics Inc | methods for treating hepatitis c |
US7868037B2 (en) * | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) * | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
MX2007000762A (en) * | 2004-07-22 | 2007-04-02 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis c. |
BRPI0917819B8 (en) * | 2008-08-22 | 2021-05-25 | Baxalta GmbH | polymeric benzyl carbonate derivative compounds, drug conjugate, pharmaceutical formulation, and use of a conjugate |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3072649A (en) * | 1963-01-08 | S-tmalkoxycinnamamide derivatives | ||
US4568687A (en) * | 1983-02-28 | 1986-02-04 | American Cyanamid Company | N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions |
US4568685A (en) * | 1984-02-29 | 1986-02-04 | American Cyanamid Company | N-[(1H-1,2,4-Triazol-1-yl)alkyl]-arylamides |
US4542145A (en) * | 1984-02-29 | 1985-09-17 | American Cyanamid Company | Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides |
US4673684A (en) * | 1984-04-04 | 1987-06-16 | Terumo Corporation | Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient |
JPS6144869A (en) * | 1984-08-10 | 1986-03-04 | Terumo Corp | Imidazole derivative and inhibitor of blood platelet aggregation containing same |
JPS6144870A (en) * | 1984-08-10 | 1986-03-04 | Terumo Corp | Unsaturated fatty acid amide derivative and inhibitor of blood platelet aggregation containing same |
JPS6212757A (en) * | 1985-07-10 | 1987-01-21 | Yoshitomi Pharmaceut Ind Ltd | Cinnamic acid amide derivative |
US4778796A (en) * | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
JPH06144869A (en) * | 1992-11-10 | 1994-05-24 | Matsunami Glass Kogyo Kk | Porous glass for biological carrier |
-
1987
- 1987-07-10 US US07/072,389 patent/US4788206A/en not_active Expired - Fee Related
-
1988
- 1988-07-06 IL IL87017A patent/IL87017A0/en unknown
- 1988-07-06 ZA ZA884857A patent/ZA884857B/en unknown
- 1988-07-07 DK DK378188A patent/DK378188A/en not_active Application Discontinuation
- 1988-07-07 NZ NZ225327A patent/NZ225327A/en unknown
- 1988-07-08 FI FI883290A patent/FI883290A/en not_active Application Discontinuation
- 1988-07-08 PH PH37197A patent/PH24605A/en unknown
- 1988-07-08 MC MC881989A patent/MC1954A1/en unknown
- 1988-07-08 HU HU883584A patent/HU205902B/en not_active IP Right Cessation
- 1988-07-08 NO NO88883084A patent/NO883084L/en unknown
- 1988-07-08 AU AU18851/88A patent/AU626526B2/en not_active Ceased
- 1988-07-08 PT PT87953A patent/PT87953B/en not_active IP Right Cessation
- 1988-07-08 YU YU132488A patent/YU46716B/en unknown
- 1988-07-08 KR KR1019880008471A patent/KR890001989A/en not_active Application Discontinuation
- 1988-07-08 EP EP88110934A patent/EP0299379B1/en not_active Expired - Lifetime
- 1988-07-08 AT AT88110934T patent/ATE88466T1/en not_active IP Right Cessation
- 1988-07-08 DE DE8888110934T patent/DE3880387D1/en not_active Expired - Fee Related
- 1988-07-08 ES ES88110934T patent/ES2054740T3/en not_active Expired - Lifetime
- 1988-07-10 JP JP63171720A patent/JPS6431766A/en active Pending
-
1991
- 1991-12-20 CZ CS913949A patent/CZ394991A3/en unknown
-
1992
- 1992-06-26 MX MX9203599A patent/MX9203599A/en unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008247903A (en) * | 1996-04-23 | 2008-10-16 | Targacept Inc | Pharmaceutical formulation for preventing and treating central nervous system disorder |
WO1997043241A1 (en) * | 1996-05-13 | 1997-11-20 | Nippon Shinyaku Co., Ltd. | Substituted ethylene compounds and drugs |
JP2006505494A (en) * | 2002-02-20 | 2006-02-16 | アボット・ラボラトリーズ | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptors |
JP2011026326A (en) * | 2002-02-20 | 2011-02-10 | Abbott Lab | Fused azabicyclic compounds which inhibit vanilloid receptor subtype 1 (vr1) receptor |
JP2006519874A (en) * | 2003-03-05 | 2006-08-31 | セルジーン・コーポレーション | Diphenylethylene compounds and uses thereof |
WO2008007780A1 (en) * | 2006-07-13 | 2008-01-17 | Kyowa Hakko Kirin Co., Ltd. | Pentadienamide derivative |
US7767705B2 (en) | 2006-08-25 | 2010-08-03 | Abbott Laboratories | Compounds that inhibit TRPV1 and uses thereof |
US8815930B2 (en) | 2006-08-25 | 2014-08-26 | Abbvie Inc. | Compounds that inhibit TRPV1 and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
US4788206A (en) | 1988-11-29 |
MC1954A1 (en) | 1989-06-30 |
KR890001989A (en) | 1989-04-07 |
YU132488A (en) | 1991-02-28 |
AU1885188A (en) | 1989-01-12 |
ATE88466T1 (en) | 1993-05-15 |
EP0299379A1 (en) | 1989-01-18 |
PT87953B (en) | 1995-03-01 |
YU46716B (en) | 1994-04-05 |
HU205902B (en) | 1992-07-28 |
AU626526B2 (en) | 1992-08-06 |
ES2054740T3 (en) | 1994-08-16 |
PH24605A (en) | 1990-08-17 |
DK378188A (en) | 1989-01-11 |
EP0299379B1 (en) | 1993-04-21 |
NZ225327A (en) | 1991-08-27 |
PT87953A (en) | 1989-06-30 |
DE3880387D1 (en) | 1993-05-27 |
FI883290A0 (en) | 1988-07-08 |
HUT48594A (en) | 1989-06-28 |
MX9203599A (en) | 1992-07-01 |
NO883084D0 (en) | 1988-07-08 |
NO883084L (en) | 1989-01-11 |
DK378188D0 (en) | 1988-07-07 |
CZ394991A3 (en) | 1993-01-13 |
ZA884857B (en) | 1989-04-26 |
IL87017A0 (en) | 1988-12-30 |
FI883290A (en) | 1989-01-11 |
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