JPS6419A - Renal function-improving and diuretic agent - Google Patents

Renal function-improving and diuretic agent

Info

Publication number
JPS6419A
JPS6419A JP63025058A JP2505888A JPS6419A JP S6419 A JPS6419 A JP S6419A JP 63025058 A JP63025058 A JP 63025058A JP 2505888 A JP2505888 A JP 2505888A JP S6419 A JPS6419 A JP S6419A
Authority
JP
Japan
Prior art keywords
renal
improving
agent
urine
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63025058A
Other languages
Japanese (ja)
Other versions
JPH0737388B2 (en
JPH0119A (en
Inventor
Isao Yamaguchi
Yoshiaki Akimoto
Hiroshi Nagao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP63025058A priority Critical patent/JPH0737388B2/en
Publication of JPS6419A publication Critical patent/JPS6419A/en
Publication of JPH0119A publication Critical patent/JPH0119A/en
Publication of JPH0737388B2 publication Critical patent/JPH0737388B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain a renal function-improving and diuretic agent, by using a specific 8-chloro-benzothiazepine compound as an active component.
CONSTITUTION: The objective agent contains 2-(4-methoxyphenyl)-3- acetoxy-5-[2-(dimethylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepine-4(5H)- one known to have excellent hypotensive action and cerebral and coronary vasodilating action or its pharmacologically permissible acid addition salt as an active component. The agent remarkably improves the abnormality in urea nitrogen level and creatinine level in blood in a state of renal insufficiency, ameliorates and prevents the lesion of renal essential tissue in chronic renal insufficiency and increases the amount of urine and the sodium ion concentration and chlorine ion concentration in urine. The compound is administered at a rate of preferably 0.05W100mg/kg, especially 0.1W10mg/kg daily for adult.
COPYRIGHT: (C)1989,JPO&Japio
JP63025058A 1987-02-10 1988-02-04 Renal function improving agent Expired - Lifetime JPH0737388B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63025058A JPH0737388B2 (en) 1987-02-10 1988-02-04 Renal function improving agent

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-29396 1987-02-10
JP2939687 1987-02-10
JP63025058A JPH0737388B2 (en) 1987-02-10 1988-02-04 Renal function improving agent

Publications (3)

Publication Number Publication Date
JPS6419A true JPS6419A (en) 1989-01-05
JPH0119A JPH0119A (en) 1989-01-05
JPH0737388B2 JPH0737388B2 (en) 1995-04-26

Family

ID=26362652

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63025058A Expired - Lifetime JPH0737388B2 (en) 1987-02-10 1988-02-04 Renal function improving agent

Country Status (1)

Country Link
JP (1) JPH0737388B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112009000695T5 (en) 2008-03-19 2011-02-10 Omron Healthcare Co., Ltd. Electronic blood pressure monitor for measuring blood pressure according to volume compensation method
US9815728B2 (en) 2010-07-12 2017-11-14 Corning Incorporated Alumina isopipes for use with tin-containing glasses
CN111447932A (en) * 2017-12-11 2020-07-24 埃塔斯制药株式会社 Renal dysfunction improving agent containing optical isomer of 1, 4-benzothiazepine-1-oxide derivative

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9062758B2 (en) 2011-12-06 2015-06-23 Sram, Llc Chainring
US9182027B2 (en) 2011-12-06 2015-11-10 Sram, Llc Chainring
JP2014148227A (en) 2013-01-31 2014-08-21 Yachiyo Industry Co Ltd Fitting structure of fuel tank to vehicle body

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225174A (en) * 1983-06-03 1984-12-18 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225174A (en) * 1983-06-03 1984-12-18 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112009000695T5 (en) 2008-03-19 2011-02-10 Omron Healthcare Co., Ltd. Electronic blood pressure monitor for measuring blood pressure according to volume compensation method
DE112009000695B4 (en) 2008-03-19 2017-11-09 Omron Healthcare Co., Ltd. Electronic blood pressure monitor for measuring blood pressure according to volume compensation method
US9815728B2 (en) 2010-07-12 2017-11-14 Corning Incorporated Alumina isopipes for use with tin-containing glasses
CN111447932A (en) * 2017-12-11 2020-07-24 埃塔斯制药株式会社 Renal dysfunction improving agent containing optical isomer of 1, 4-benzothiazepine-1-oxide derivative

Also Published As

Publication number Publication date
JPH0737388B2 (en) 1995-04-26

Similar Documents

Publication Publication Date Title
IE781478L (en) IMIDAZO £2,1-b| QUINAZOLINES
Midtbø et al. Verapamil compared with nifedipine in the treatment of essential hypertension
JPS6419A (en) Renal function-improving and diuretic agent
EP0344997A3 (en) Use of phytic acid or a salt thereof as an activator of hypoxic cells and a circulatory ameliorator
Berg et al. Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs
GB2178314A (en) Pharmaceutical compositions containing ubiquinone coenzymes
CA1300024C (en) Agent having renal function-improving effect and diuretic effect
O'Hare et al. Evidence of increased parathyroid activity on discontinuation of high-aluminum dialysate in patients undergoing hemodialysis
Walker et al. Acute interstitial nephritis in a patient taking tienilic acid.
JPS56156218A (en) Inhibitor against blood platelet agglutination
KIRKENDALL Clinical evaluation of chlorothiazide
FR2547730B1 (en) HYPOLIPIDEMIC DRUG CONTAINING AS ACTIVE INGREDIENT D-3-ACETOXY-CIS-2,3-DIHYDRO-5- (2- (DIMETHYLAMINO) ETHYL) -2- (P-METHOXYPHENYL) -1,5-BENZOTHIAZEPINE-4 (5H) -ONE OR ONE OF ITS SALTS OF ADDITION OF ACIDS ACCEPTABLE IN PHARMACY
IE781226L (en) Antithrombatic compound
Scanu et al. Reversible acute renal insufficiency with combination of enalapril and diuretics in a patient with a single renal-artery stenosis
EP0246573A3 (en) Pharmaceutical composition containing a 8-chlorobenzothiazepine compound and its use
Boero et al. Verapamil in arterial hypertension with renal disease
JPS6112892B2 (en)
Hoes et al. Circadian rhythm in plasma concentrations of gamma-hydroxybutyric acid in alcoholics
JPS56156217A (en) Inhibitor against blood platelet agglutination
Garay et al. Evidence for the O-sulfo derivative of MK-447 as active metabolite of MK-447
Jensen et al. Clinical and haemodynamic study of Minoxidil in moderately hypertensive patients
Andersson et al. Felodipine in combination with a β-blocker and a diuretic in chronic treatment of patients with refractory primary hypertension
KR960701644A (en) METHOD AND COMPOSITION FOR TREATMENT OF OSTEOPOROSIS
Hamer et al. Adverse effects of lisinopril.
Mimran et al. Nitrendipine enhances the effect of adrenaline on serum potassium in normal man.