JPS641144B2 - - Google Patents
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- Publication number
- JPS641144B2 JPS641144B2 JP56026131A JP2613181A JPS641144B2 JP S641144 B2 JPS641144 B2 JP S641144B2 JP 56026131 A JP56026131 A JP 56026131A JP 2613181 A JP2613181 A JP 2613181A JP S641144 B2 JPS641144 B2 JP S641144B2
- Authority
- JP
- Japan
- Prior art keywords
- sterilization
- gas
- compressor
- valve
- sterilization chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- 230000001954 sterilising effect Effects 0.000 claims description 157
- 238000004659 sterilization and disinfection Methods 0.000 claims description 124
- 238000000034 method Methods 0.000 claims description 40
- 238000007906 compression Methods 0.000 claims description 10
- 230000006835 compression Effects 0.000 claims description 9
- 239000007789 gas Substances 0.000 description 62
- 230000000694 effects Effects 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 3
- 239000006200 vaporizer Substances 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000020169 heat generation Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Description
【発明の詳細な説明】
この発明は、酸化エチレン、ホルマリン其他の
滅菌ガスを用いて医療器具、医科材料等の滅菌を
行なうガス滅菌方法に関し、機械的圧縮手段を使
用して滅菌ガス等を段階的に圧縮循環させて能率
よく良好なガス滅菌が行なえる方法を得ることを
目的として発明されたものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a gas sterilization method for sterilizing medical instruments, medical materials, etc. using ethylene oxide, formalin, and other sterilizing gases, and the present invention relates to a gas sterilization method for sterilizing medical instruments, medical materials, etc. using ethylene oxide, formalin, and other sterilizing gases. This invention was invented with the aim of providing a method that enables efficient and good gas sterilization through compression circulation.
従来のガス滅菌方法としては
(a) 耐圧性、気密性の高い滅菌室に、滅菌ガスを
加圧供給して該室内に密閉した被滅菌物を滅菌
する方法。 Conventional gas sterilization methods include (a) a method in which sterilizing gas is supplied under pressure to a sterilization chamber with high pressure resistance and airtightness to sterilize objects to be sterilized sealed in the chamber;
(b) 耐圧性の弱い気密性滅菌室に滅菌ガスを弱い
加圧状態で供給して滅菌する方法。(b) A method of sterilizing by supplying sterilizing gas under weak pressure to an airtight sterilization chamber with weak pressure resistance.
(c) 上記(a)、(b)の方法において、滅菌室内を、内
部または外部から加熱し温度調節して滅菌効率
をよくする滅菌方法。(c) In methods (a) and (b) above, a sterilization method that improves sterilization efficiency by heating the sterilization chamber from the inside or outside and adjusting the temperature.
(d) 小容量のプラスチツク袋に、被滅菌物を常温
常圧の滅菌ガスと共に封入して滅菌する方法。(d) A method of sterilizing objects by enclosing them in a small plastic bag together with sterilizing gas at room temperature and pressure.
(e) 滅菌効率をよくするため、上記(a)〜(d)の方法
において、循環通路と循環用ポンプとを設けて
滅菌ガスを循環させる方法。(e) In order to improve sterilization efficiency, a method in which a circulation passage and a circulation pump are provided to circulate the sterilizing gas in the methods (a) to (d) above.
等がある。上記の内、
(a)の方法は強度保持のため、滅菌室を厚い鋼板
製の圧力容器としなければならないから、装置の
重量が大となり、大型化して高価になり、また滅
菌ガスを常温で使用するので滅菌効率が悪いとい
う欠点がある。etc. Among the above methods, method (a) requires the sterilization chamber to be a pressure vessel made of thick steel plates in order to maintain its strength, which increases the weight, size, and cost of the equipment. The disadvantage is that the sterilization efficiency is poor because of the use of
(b)の方法は、滅菌室の重量増加、大型化等は避
けられるが、(a)の方法と同様に滅菌効率は悪い。 Although method (b) avoids increasing the weight and size of the sterilization room, it has poor sterilization efficiency like method (a).
(c)の方法は、滅菌効率は比較的改善されるが、
滅菌ガスが静止状態であるため、滅菌室内のガス
分布が不均一になり、滅菌速度が低下するという
欠点がある。 Method (c) has relatively improved sterilization efficiency, but
Since the sterilizing gas is stationary, the gas distribution within the sterilization chamber is uneven, which reduces the sterilization speed.
(d)の方法は、滅菌効率が悪い上に、被滅菌物が
少数且つ比較的小型のものに限定され、大容量の
滅菌ができないという欠点がある。 Method (d) has the drawback that it has poor sterilization efficiency, and is limited to a small number of objects to be sterilized and relatively small, and cannot sterilize large volumes.
(e)の方法は、滅菌ガスを循環させるため滅菌効
率は良好であるが、滅菌ガスに圧力を加えるため
のポンプ等の機械が必要であり、この循環用ポン
プの軸のシール部からガスが漏れ易く、循環装置
に使用するモータ、リレー等の火花が引火する危
険がある。またガスの圧縮、摩擦、各機械の発熱
等の発熱現象を伴うため、冷却装置を設けなけれ
ばならず、ドレンセパレータが必要になる等付帯
設備が多くなり、これに付随する運転保守経費が
高くなる欠点がある。さらにこの方法では加湿制
御が難しい。 Method (e) has good sterilization efficiency because the sterilizing gas is circulated, but it requires a machine such as a pump to apply pressure to the sterilizing gas, and the gas is released from the seal on the shaft of this circulation pump. It leaks easily, and there is a risk of ignition from sparks from motors, relays, etc. used in circulation devices. In addition, because it involves heat generation phenomena such as gas compression, friction, and heat generation from each machine, a cooling device must be installed, and additional equipment such as a drain separator is required, resulting in high operation and maintenance costs. There is a drawback. Furthermore, humidification control is difficult with this method.
等の欠点がある。There are drawbacks such as.
本発明は、滅菌室を経由する滅菌ガスの閉循環
回路を形成すると共に、ガスの有するエネルギを
利用して循環を有効に行なわせるガス滅菌の方法
を得たもので、滅菌ガスの圧力を滅菌室内で段階
的に変動させて被滅菌物の温度上昇を促し、被滅
菌物の内部まで浸透させて、滅菌効率を向上させ
るようにしたものである。 The present invention provides a gas sterilization method that forms a closed circulation circuit for sterilizing gas via a sterilization chamber and effectively performs the circulation by utilizing the energy of the gas. The temperature of the object to be sterilized is increased by changing the temperature in stages indoors, and the temperature penetrates into the object to improve sterilization efficiency.
以下、図示の実施例に従つて本発明を説明す
る。 The present invention will be described below with reference to illustrated embodiments.
１は外筒２で囲まれた密閉可能な滅菌室であつ
て、使用内圧は大気圧よりやや高い程度で済むか
ら特別に丈夫に造る必要はない。滅菌室１と滅菌
ガスを加圧充填した滅菌ガス容器３とは管４、弁
５、管６、滅菌ガス気化器７を経て、管８、吸引
器９、管１０、圧縮機３２の吸入側に設けた弁３
１、管３５、圧縮機３２、管３６、圧縮タンク３
３、管３７、圧縮機３２の吐出側に設けた弁３
４、加温器１１、管１２を通り、滅菌室１内の拡
散ノズル１３に通じている。吸引器９としては、
図示の例ではエジエクタを使用している。管８に
は空気過器１４が弁１５を介して管１６により
通じており、無菌空気を管８に送入できるように
している。滅菌室１は、管１７により吸引器９に
通じており、管１７，１０，３５，３６，３７，
１２により滅菌室を通る循環回路が形成されてい
る。滅菌室１内を真空にするための真空ポンプ
が、管１９、弁２０、管２１を経て滅菌室１に通
じており、該真空ポンプ１８の排気口は管２２に
より滅菌残ガス処理器２３に通じている。外筒２
内の流体は、管２４、循環ポンプ２５、管２６、
加温器２７、管２８、加温器１１、管２９を経て
循環する。３０は滅菌室１の圧力を示す圧力計で
ある。 Reference numeral 1 is a hermetically sealed sterilization chamber surrounded by an outer cylinder 2, and since the internal pressure for use can be slightly higher than atmospheric pressure, there is no need to make it particularly strong. The sterilization chamber 1 and the sterilization gas container 3 filled with sterilization gas under pressure pass through a pipe 4, a valve 5, a pipe 6, a sterilization gas vaporizer 7, a pipe 8, an aspirator 9, a pipe 10, and the suction side of a compressor 32. Valve 3 installed in
1, pipe 35, compressor 32, pipe 36, compression tank 3
3, pipe 37, valve 3 provided on the discharge side of the compressor 32
4, a warmer 11, a tube 12, and a diffusion nozzle 13 in the sterilization chamber 1. As the suction device 9,
The illustrated example uses an ejector. An air strainer 14 communicates with the tube 8 via a valve 15 and a tube 16, making it possible to introduce sterile air into the tube 8. The sterilization chamber 1 communicates with the suction device 9 by a tube 17, which includes tubes 17, 10, 35, 36, 37,
12 forms a circulation circuit passing through the sterilization chamber. A vacuum pump for creating a vacuum in the sterilization chamber 1 is connected to the sterilization chamber 1 through a pipe 19, a valve 20, and a pipe 21, and the exhaust port of the vacuum pump 18 is connected to a sterilization residual gas processor 23 through a pipe 22. I understand. Outer cylinder 2
The fluid inside the pipe 24, the circulation pump 25, the pipe 26,
It circulates through the warmer 27, tube 28, warmer 11, and tube 29. 30 is a pressure gauge that indicates the pressure in the sterilization chamber 1.
上記のように構成されるガス滅菌装置による滅
菌作用を次に工程順に説明する。 The sterilization effect of the gas sterilizer configured as described above will now be explained step by step.
(1) 準備工程
加温器２７を、滅菌室１内が使用滅菌ガスの
性質に応じて滅菌に最も適した温度になるよう
な温度に設定して、外筒２に充填した流体をポ
ンプ２５により循環させつつ滅菌室内を加温す
る。該流体の種類は液体でも気体でもよいが、
比熱や使い易さ等の点で水が便利である。(1) Preparation process The warmer 27 is set to a temperature that will bring the inside of the sterilization chamber 1 to the most suitable temperature for sterilization depending on the properties of the sterilization gas used, and the fluid filled in the outer cylinder 2 is heated to the pump 25. The inside of the sterilization room is heated while being circulated. The type of fluid may be liquid or gas, but
Water is convenient in terms of specific heat and ease of use.
(2) 減圧工程
滅菌室１に被滅菌物を入れて密閉し、弁５，
１５を閉じ、弁２０を開いて真空ポンプ１８を
運転する。これにより滅菌室１内はほぼ真空に
なり、被滅菌物に含まれていた空気、湿気が排
除される。(2) Depressurization process Put the items to be sterilized into the sterilization chamber 1, seal it, and close the valve 5.
15 is closed, valve 20 is opened, and vacuum pump 18 is operated. As a result, the inside of the sterilization chamber 1 becomes almost vacuum, and the air and moisture contained in the objects to be sterilized are eliminated.
(3) 無菌空気送入加温工程
次に、弁２０を閉じ、弁３１，３４を開き圧
縮機３２を運転し、弁１５を少し開いて（弁５
は閉じたまま）、滅菌室１に大気圧近くまで無
菌空気を吸入させる。この無菌空気は、加温器
１１を経て加温されて拡散ノズル１３から低圧
の滅菌室１内に吹出し、室内の被滅菌物を加温
するが、滅菌室に入つた空気の一部は吸引器９
を通る無菌空気の流れのため管１７を通つて吸
出され、ノズル１３から再び滅菌室１に吹込ま
れる。このようにして加温空気が滅菌室内で流
動するから、被滅菌物と加温空気との接触が良
好になる。滅菌室に入る無菌空気の量が多くな
るに従つて上記の流動は弱くなり、室内は大気
圧に近くなる。(3) Sterile air supply heating step Next, valve 20 is closed, valves 31 and 34 are opened to operate the compressor 32, and valve 15 is slightly opened (valve 5
(remains closed), and sterile air is sucked into the sterilization chamber 1 to a pressure close to atmospheric pressure. This sterile air is heated through the heater 11 and blown out from the diffusion nozzle 13 into the low-pressure sterilization chamber 1 to warm the objects to be sterilized in the chamber, but some of the air that has entered the sterilization chamber is sucked out. Vessel 9
The sterile air flows through the tube 17 and is blown into the sterilization chamber 1 again through the nozzle 13 . Since the heated air flows in the sterilization chamber in this way, good contact between the objects to be sterilized and the heated air is achieved. As the amount of sterile air entering the sterilization room increases, this flow becomes weaker and the pressure in the room approaches atmospheric pressure.
(4) 昇温工程
前記の(2)減圧工程と同様に弁５，１５を閉
じ、弁２０を開いた状態で真空ポンプ１８を運
転して、滅菌室１内を真空状態にし、続いて(3)
の無菌空気送入工程を行なう。これにより再び
加温された無菌空気が滅菌室１に送入され、被
滅菌物を加温する。(4) Temperature raising step As in the above (2) pressure reduction step, the valves 5 and 15 are closed, the vacuum pump 18 is operated with the valve 20 open, the inside of the sterilization chamber 1 is brought into a vacuum state, and then ( 3)
Perform the sterile air supply process. As a result, the heated sterile air is sent into the sterilization chamber 1 again, and warms the objects to be sterilized.
この排気、給気の繰返しを、被滅菌物の温度
が滅菌条件に合致するようになるまで行ない、
最後は滅菌室１を真空状態としてこの工程を終
る。 This evacuation and air supply are repeated until the temperature of the object to be sterilized meets the sterilization conditions.
Finally, the sterilization chamber 1 is brought to a vacuum state to complete this process.
(5) 滅菌工程
弁１５，２０を閉じ弁５を開いて気化器７を
通して滅菌ガスを管１０に流す。このとき弁３
４を閉じ、圧縮機３２を作動させて圧縮タンク
３３に所定の圧力になるまでガスを圧入する。
次に弁５，３１を閉じ、弁３４を開いて滅菌ガ
スを滅菌室１に進入させる。次に再び弁５，３
１を開き弁３４を閉じて圧縮機３２を作動さ
せ、圧縮タンク３３に所定の圧力になるまでガ
スを圧入する。次に再び弁５，３１を閉じ弁３
４を開いてガスを滅菌室に供給する。すなわ
ち、圧力計３０を見ながらガス容器３から適量
の滅菌ガスを滅菌室１に送入する工程の内で上
記圧縮工程を繰返す事により給ガスが段階的に
行なわれ、滅菌室の圧力が第２図ａのように脈
動的に上昇する。すなわち、常圧p0以上になる
と吸引器９を通じて滅菌室１の残留微量空気と
混合した滅菌ガスも吸出され圧縮され、加温器
１１を通つて再供給されるため、滅菌ガスが滅
菌室１内を流動し、加温効果を上げる事が出来
る。所定の余り高くない圧力で滅菌室１に充満
した滅菌ガスは、このようにして圧力のゆさぶ
りをかける事により滅菌ガスの被滅菌物への浸
透を良好にする事が出来る。(5) Sterilization process Valves 15 and 20 are closed, valve 5 is opened, and sterilization gas is allowed to flow into pipe 10 through vaporizer 7. At this time valve 3
4 is closed, the compressor 32 is operated, and gas is pressurized into the compression tank 33 until a predetermined pressure is reached.
Next, valves 5 and 31 are closed, and valve 34 is opened to allow sterilization gas to enter the sterilization chamber 1. Then valves 5 and 3 again
1 and closes the valve 34 to operate the compressor 32 and pressurize gas into the compression tank 33 until a predetermined pressure is reached. Next, close valves 5 and 31 again and valve 3
4 to supply gas to the sterilization chamber. That is, in the process of feeding an appropriate amount of sterilizing gas from the gas container 3 into the sterilization chamber 1 while watching the pressure gauge 30, the above compression process is repeated to supply gas in stages, and the pressure in the sterilization chamber is gradually increased. It rises pulsatingly as shown in Figure 2a. That is, when the pressure reaches normal pressure p 0 or higher, the sterilizing gas mixed with the residual trace amount of air in the sterilization chamber 1 is also sucked out and compressed through the suction device 9, and is resupplied through the warmer 11, so that the sterilization gas is supplied to the sterilization chamber 1. It can flow inside and increase the heating effect. The sterilizing gas filled in the sterilizing chamber 1 at a predetermined, not very high pressure can be made to penetrate into the objects to be sterilized by changing the pressure in this way.
滅菌室１内の滅菌ガス圧力が所定の大きさに
なつたならば、弁５を閉じ滅菌ガスの供給を停
める。その後も弁３４を閉じ圧縮機３２を作動
させて圧縮タンク３３に所定の圧力になるまで
滅菌ガスを圧入し、次に弁３１を閉じ弁３４を
開いて滅菌室１に滅菌ガスを吹出させる工程を
繰返すことにより、第２図ｂのように滅菌ガス
圧を脈動させて滅菌効果を高めることが出来
る。 When the sterilization gas pressure in the sterilization chamber 1 reaches a predetermined level, the valve 5 is closed to stop the supply of sterilization gas. Thereafter, the process of closing the valve 34 and operating the compressor 32 to pressurize sterilizing gas into the compression tank 33 until a predetermined pressure is reached, then closing the valve 31 and opening the valve 34 to blow out the sterilizing gas into the sterilization chamber 1 By repeating this, the sterilizing gas pressure can be pulsated as shown in FIG. 2b, thereby increasing the sterilizing effect.
すなわち、滅菌ガスを所定の圧力で滅菌室１
に充填したまま放置し所定時間を経過させる従
来の方法と異なり、積極的に圧力を変動させる
事により滅菌ガスがすみやかに被滅菌物に浸透
するため滅菌室の温度分布がよくなり、加温も
され従来の滅菌時間を短縮する事も可能であ
る。 In other words, sterilization gas is supplied to the sterilization chamber 1 at a predetermined pressure.
Unlike the conventional method of leaving the chamber filled and leaving it for a predetermined period of time, by actively varying the pressure, the sterilization gas quickly penetrates the objects to be sterilized, improving the temperature distribution in the sterilization chamber and making it easier to heat the chamber. It is also possible to shorten the conventional sterilization time.
圧力の変動の巾を、例えば0.25〜0.3Kg／cm2
位にすれば、圧力差の制御も時間的制御、圧力
的制御も比較的容易であり、圧縮機にも無理が
かからないように出来る。 The range of pressure fluctuation, for example, 0.25 to 0.3Kg/cm 2
If the pressure difference is controlled at a certain position, pressure difference control, time control, and pressure control are relatively easy, and the compressor can be prevented from being overloaded.
また、所定の圧力に達したところで、滅菌室
内の温度、圧力を監視し制御する事により、例
えば50℃で100分が適当な滅菌時間とすれば、
これを40℃で150分（すなわち50％増）、60℃で
50分（すなわち50％減）のように滅菌時間を変
動させるフイードバツク機能を持たせて滅菌時
間を制御することができる。 In addition, by monitoring and controlling the temperature and pressure inside the sterilization chamber when the predetermined pressure is reached, for example, if a suitable sterilization time is 100 minutes at 50℃,
This was done at 40°C for 150 minutes (i.e. 50% increase) and at 60°C.
The sterilization time can be controlled by providing a feedback function to vary the sterilization time, such as 50 minutes (ie, 50% reduction).
滅菌室内の圧力変化に対してもガス濃度を計
算して滅菌時間を決めることが出来るから、結
局、圧力変化、温度変化に対して十分な滅菌処
理を行なわせるために、コンピユータ制御装置
にプログラムまたは回路を組むことによりリレ
ーシーケンスでは困難であつた適正処理機能を
持たせて滅菌工程を自動制御することができる
のである。 Since the sterilization time can be determined by calculating the gas concentration in response to pressure changes in the sterilization chamber, the computer control device must be programmed or By assembling a circuit, it is possible to automatically control the sterilization process by providing appropriate processing functions that are difficult to achieve with relay sequences.
(6) 滅菌ガス排除工程
所定時間の経過後、弁２０を開き、真空ポン
プ１８を運転して、滅菌室１や管内の滅菌ガス
を残ガス処理器２３を通して排出する。被滅菌
物に浸透していた滅菌ガスは迅速に拡散し排出
される。(6) Sterilization gas removal step After a predetermined period of time has elapsed, the valve 20 is opened, the vacuum pump 18 is operated, and the sterilization gas in the sterilization chamber 1 and the pipes is discharged through the residual gas processor 23. The sterilization gas that has permeated the object to be sterilized is quickly diffused and exhausted.
(7) 被滅菌物取出し工程
弁２０を閉じ真空ポンプ１８を停止させ、弁
１５を開いて無菌空気を拡散ノズル１３から滅
菌室１に送入し、滅菌室内をほぼ大気圧にして
滅菌処理済の被滅菌物を取出す。(7) Retrieval process of objects to be sterilized Close the valve 20 to stop the vacuum pump 18, open the valve 15 and send sterile air from the diffusion nozzle 13 into the sterilization chamber 1, and bring the inside of the sterilization chamber to almost atmospheric pressure to complete the sterilization process. Remove the items to be sterilized.
以上のようにして行なわれる滅菌処理において
は、次のような作用、効果がある。 The sterilization process performed as described above has the following effects and effects.
(1) 滅菌室１内は、外筒２を流通する加温流体に
よる輻射で温められるのに併せて、加温した無
菌空気を滅菌室１に送入する際に、吸引器９に
より滅菌室内空気の一部が吸出され循環するか
ら、被滅菌物と流動する加温空気との接触がよ
くなり、滅菌室内の温度分布が一様になると共
に、加温速さが大きくなる。(1) The inside of the sterilization chamber 1 is heated by radiation from the heating fluid flowing through the outer cylinder 2, and when the heated sterile air is fed into the sterilization chamber 1, the suction device 9 is used to cool the sterilization chamber. Since a portion of the air is sucked out and circulated, the objects to be sterilized come into good contact with the flowing heated air, the temperature distribution within the sterilization chamber becomes uniform, and the heating rate increases.
(2) 滅菌ガス送入時にも常圧以上になると同様の
循環作用が行なわれ、滅菌ガスが流動して均等
に分散されると共に被滅菌物との接触が良好に
なり、被滅菌物へのガス浸透が良好になる。(2) When the sterilizing gas is supplied, a similar circulation effect occurs when the pressure reaches normal pressure or higher, and the sterilizing gas flows and is evenly dispersed, making good contact with the objects to be sterilized, and reducing the Good gas penetration.
(3) 滅菌室内の圧力を高めないで加温した滅菌ガ
スの循環により滅菌効果を高めるから、滅菌室
の強度を大きくする必要がない。(3) The sterilization effect is enhanced by circulating the heated sterilizing gas without increasing the pressure inside the sterilization chamber, so there is no need to increase the strength of the sterilization chamber.
(4) 滅菌ガスの温度、圧力を段階的に変動させ
る、すなわち、ゆさぶりをかけるためガスの浸
透が良く、従来の静止型の滅菌方法に比べて滅
菌時間が短かくてすむ。(4) Since the temperature and pressure of the sterilizing gas are varied in stages, that is, shaking is applied, the gas penetrates better, and the sterilization time is shorter than that of conventional static sterilization methods.
(5) 真空ポンプ１８、循環ポンプ２５、圧縮機３
２を作動させるが、圧縮機３２については圧力
差0.25〜0.3Kg／cm2と比較的少ない為にくり返
し動作させても保守に関する配慮が少なくてす
む。(5) Vacuum pump 18, circulation pump 25, compressor 3
However, since the pressure difference in the compressor 32 is relatively small at 0.25 to 0.3 Kg/cm 2 , even if it is operated repeatedly, there is little need to consider maintenance.
(6) 滅菌工程における温度、圧力を監視し制御す
る事により滅菌に必要な温度、圧力（ガス濃
度）の必要量を最低限にし、しかも滅菌効果を
確実にすることが出来る。(6) By monitoring and controlling the temperature and pressure during the sterilization process, it is possible to minimize the amount of temperature and pressure (gas concentration) necessary for sterilization, and to ensure the sterilization effect.
なお、滅菌ガスの送入に先立つて配管内に蒸気
を送入し加湿したり、滅菌ガスの効果を高めるた
めの助剤ガスを送入したりする工程を付加する場
合も、前記の昇温、滅菌のための空気やガスの循
環と同様の操作で操作できるものである。 In addition, when adding steps such as introducing steam into the piping to humidify the pipe or introducing an auxiliary gas to enhance the effectiveness of the sterilizing gas before supplying the sterilizing gas, the temperature increase described above may also be applied. , which can be operated in the same manner as air or gas circulation for sterilization.
なお、滅菌器内圧力を脈動的に変動させること
が特開昭56−15751号公報に記載されているが、
このものは滅菌工程前のコンデイシヨニング工程
に行なうもので、操作方法も異なつており、本発
明とは別異である。 Furthermore, although it is described in JP-A-56-15751 that the pressure inside the sterilizer is varied in a pulsating manner,
This method is carried out in the conditioning step before the sterilization step, and the operating method is different from that of the present invention.
第１図は本発明を実施するための装置の略図、
第２図は滅菌室内の圧力変化を示す線図である。
１：滅菌室、３：ガス容器、５：弁、７：滅菌
ガス気化器、９：吸引器、１１：加温器、１４：
空気過器、１５：弁、１７：管、１８：真空ポ
ンプ、２０：弁、２５：循環ポンプ、３１，３
４：弁、３２：圧縮機、３３：圧縮タンク。
FIG. 1 is a schematic diagram of an apparatus for carrying out the invention;
FIG. 2 is a diagram showing pressure changes within the sterilization chamber. 1: Sterilization room, 3: Gas container, 5: Valve, 7: Sterile gas vaporizer, 9: Suction device, 11: Warmer, 14:
Air filter, 15: Valve, 17: Pipe, 18: Vacuum pump, 20: Valve, 25: Circulation pump, 31,3
4: Valve, 32: Compressor, 33: Compression tank.
Claims (1)
内の気体を抽出する吸引器９を、圧縮機吸入側の
弁３１を介して圧縮機３２の吸入側に接続し、圧
縮機３２の吐出側を順次、圧縮タンク３３、圧縮
機吐出側の弁３４、加温器１１を経て滅菌室１に
通じさせた構成部分を持つ滅菌装置を使用するガ
ス滅菌方法であつて、被滅菌物を収めた滅菌室を
真空状態に減圧する減圧工程と、加温した無菌空
気を滅菌室に送入して滅菌室の内圧を大気圧程度
にする無菌空気送入工程と、上記の減圧工程と無
菌空気送入工程とを繰返して被滅菌物の温度を必
要程度まで高める昇温工程と、真空状態にした滅
菌室にガス容器に充填した加圧滅菌ガスを送入す
る滅菌工程と、滅菌室から滅菌ガスを排出後、無
菌空気をほぼ大気圧になるまで送入して被滅菌物
を取出す被滅菌物取出し工程とから成り、滅菌工
程においては、圧縮機吸入側の弁３１を開き圧縮
機吐出側の弁３４を閉じ圧縮機３２を運転して滅
菌ガスを圧縮タンク３３に蓄積し、この加圧滅菌
ガスを、圧縮機吸入側の弁３１を閉じ圧縮機吐出
側の弁３４を一時的に開いて滅菌室１に噴出さ
せ、次に圧縮機吐出側の弁３４を閉じ圧縮機吸入
側の弁３１を開いて滅菌ガス源から供給される滅
菌ガス及び滅菌室１から抽出した滅菌ガスを圧縮
タンク３３に蓄積すると共に滅菌室１の内圧を少
し低くし、この操作を繰返してガス圧を脈動的に
高低を繰返しつつ滅菌ガスを供給して滅菌室１内
のガス圧を上昇させ、滅菌ガス源からの滅菌ガス
送給を絶つた後も滅菌室１から抽出した滅菌ガス
を圧縮し蓄積し、間欠的に滅菌室１へ噴出させて
滅菌室内ガス圧を脈動的に変動させるようにした
ことを特徴とするガス滅菌方法。1 Sterilization room 1 by circulating sterile gas or clean air
A suction device 9 for extracting gas from the compressor is connected to the suction side of the compressor 32 via a valve 31 on the suction side of the compressor, and the discharge side of the compressor 32 is connected to the compressor tank 33 and then to the valve on the compressor discharge side. 34. A gas sterilization method using a sterilizer having a component part communicated with the sterilization chamber 1 through the heater 11, which includes a depressurization step of reducing the pressure of the sterilization chamber containing the objects to be sterilized to a vacuum state, and a pressurization step. A sterile air supply process in which warmed sterile air is sent into the sterilization chamber to bring the internal pressure of the sterilization chamber to atmospheric pressure, and the above depressurization process and sterile air supply process are repeated to maintain the temperature of the object to be sterilized. a sterilization process in which autoclaved gas filled in a gas container is fed into the sterilization chamber in a vacuum state, and after the sterilization gas is discharged from the sterilization chamber, the sterile air is heated until it reaches almost atmospheric pressure. The sterilization process consists of a step of taking out the object to be sterilized by feeding the object and taking out the object to be sterilized.In the sterilization step, the valve 31 on the suction side of the compressor is opened, the valve 34 on the discharge side of the compressor is closed, and the compressor 32 is operated to remove the sterilized gas. is accumulated in the compression tank 33, and this autoclaved gas is ejected into the sterilization chamber 1 by closing the valve 31 on the compressor suction side and temporarily opening the valve 34 on the compressor discharge side. Close the valve 34 on the compressor suction side and open the valve 31 on the compressor suction side to accumulate the sterilization gas supplied from the sterilization gas source and the sterilization gas extracted from the sterilization chamber 1 in the compression tank 33, and at the same time lower the internal pressure of the sterilization chamber 1 a little. This operation is repeated to supply sterilizing gas while repeatedly raising and lowering the gas pressure in a pulsating manner to increase the gas pressure in the sterilizing chamber 1, and even after the sterilizing gas supply from the sterilizing gas source is cut off, the sterilizing chamber 1 remains unchanged. A gas sterilization method characterized in that the sterilization gas extracted from the sterilization chamber is compressed and accumulated, and is intermittently ejected into the sterilization chamber 1, thereby pulsating the gas pressure in the sterilization chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56026131A JPS57142254A (en) | 1981-02-26 | 1981-02-26 | Gas pasturization method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56026131A JPS57142254A (en) | 1981-02-26 | 1981-02-26 | Gas pasturization method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57142254A JPS57142254A (en) | 1982-09-02 |
| JPS641144B2 true JPS641144B2 (en) | 1989-01-10 |
Family
ID=12185001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56026131A Granted JPS57142254A (en) | 1981-02-26 | 1981-02-26 | Gas pasturization method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57142254A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0576897U (en) * | 1992-03-24 | 1993-10-19 | 株式会社ケンウッド | Car TV monitor |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4106814B2 (en) * | 1999-06-18 | 2008-06-25 | 澁谷工業株式会社 | Sterilizer |
| WO2010104948A1 (en) * | 2009-03-12 | 2010-09-16 | Saian Corporation | Sterilization method |
| JP6631031B2 (en) * | 2015-04-24 | 2020-01-15 | キヤノンマーケティングジャパン株式会社 | Sterilization method |
| KR101846251B1 (en) * | 2016-08-17 | 2018-04-09 | 주식회사 큐브인스트루먼트 | Method Using Low Temperature Sterilizer Having Chamber of Which Volume Is Variable |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5615751A (en) * | 1979-07-20 | 1981-02-16 | American Sterilizer Co | Method and device for sterilization |
-
1981
- 1981-02-26 JP JP56026131A patent/JPS57142254A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0576897U (en) * | 1992-03-24 | 1993-10-19 | 株式会社ケンウッド | Car TV monitor |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57142254A (en) | 1982-09-02 |
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