JPS6355965B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to an improvement in a solute permeation device that permeates a solute by a liquid film method, and more specifically, the present invention relates to an improvement in a solute permeation device that permeates a solute using a liquid film method. The present invention relates to a permeation device used to concentrate, extract, or remove specific substances in the presence of various solutes by forming complexes and transporting them. Conventionally, there are two types of solute permeation devices: an H-tube type and a U-tube type. The U-tube type is used when the specific gravity of the solvent containing the solute is greater than the specific gravity of the solvent containing the solute transport carrier.
Since the solvent containing the solute transport carrier is placed at the bottom of the U-shaped tube, and the solvent containing and not containing the solute are placed in the vertical tubes on both sides,
It is used when the specific gravities of the solvent containing the solute transport carrier and the solvent containing the solute (hereinafter referred to as two solvents or both solvents) are opposite to the above. As described above, the conventional H-tube type and U-tube type solute permeation devices are complicated in that they must be used depending on which of the two solvents has a higher specific gravity, and the difference in specific gravity between the two solvents is There was a problem that if there was almost no solute, it was impossible to permeate the solute. Furthermore, in these solute permeation devices, two poorly soluble solvents are separated based on the difference in their specific gravity, so not only must careful stirring be done to prevent them from directly mixing, but the permeation path is There was also the problem that it was long. In addition, other conventional solute permeation devices use a microporous polymer membrane or cellulose impregnated with a transport carrier alone or with a solvent; The problem was that the absolute amount of transport carrier that could be produced was small. The present invention has been made in view of the above, and can be used regardless of the specific gravity of two solvents, even when there is almost no difference in specific gravity between them, and allows for efficient permeation of solutes and ease of handling. The present invention also aims to provide a simple solute permeation device. Hereinafter, embodiments of the present invention will be described in detail based on the drawings. In FIG. 1, reference numerals 1, 1 are substantially L-shaped tubes having the same configuration and facing each other, and these tubes 1 are as follows: It is composed of a vertical tube section 1a having a liquid inlet 1d at its upper end, and a horizontal tube section 1b having an opening 1e at opposite ends thereof, and a flange section 1c for clamping around the opening 1e. is formed.
These tube bodies 1, 1 can be made of glass, stainless steel, plastic, etc.
Considering the chemical stability against the solvent contained therein and the difficulty of processing, it is best to use glass. Note that the injection ports 1d and 1d can be covered with lids to prevent the liquid contained therein from evaporating, and furthermore, a PH electrode, a thermometer, etc. can be inserted into the liquid from these injection ports 1d and 1d. Various measuring instruments can be inserted. The annular body 2 disposed between the tube bodies 1, 1 is
A liquid injection hole (approximately 1 mm in diameter) opened to the outside is formed in the upper part of the peripheral wall to enable liquid to be injected into the annular body 2 from the hole 2a with a cylinder or the like. A plug 3 is inserted into the housing to prevent the liquid inside from flowing out or evaporating. These annular bodies 2
The stopper 3 is made of fluororesin or other synthetic resin, glass, or the like which is insoluble in the liquid to be contained. Further, the annular body 2 is available in various thicknesses ranging from several mm to several centimeters depending on the conditions of use, and can be used by changing them according to the conditions of use. Diaphragms 4, 4 disposed on both sides of the annular body 2
is composed of a synthetic polymer membrane, cellulose membrane (filter paper), etc., which is insoluble in the liquid that comes into contact with it and is permeable to solutes in the liquid. Note that in order to increase the permeation rate, a microporous membrane having a large number of fine pores of an appropriate diameter can also be used. In addition, these diaphragms 4, 4
A sealing annular gasket 5 made of a material such as fluororesin, similar to the annular body 2, is disposed on the outer side of the annular body 2, and a plurality of these gaskets 5 are layered to achieve liquid tightness. can be increased. The fixing means for integrating the tubes 1, 1, the annular body 2, the diaphragms 4, 4, etc. includes a pair of clamping plates 7, 7 facing each other with the flange portions 1c, 1c of the tubes 1, 1 interposed therebetween; It is constituted by bolts 8, 8 and nuts 9, 9 that fasten them, and by the fastening, three cells are formed inside the tube bodies 1, 1 and the annular body 2, respectively partitioned by diaphragms 4, 4. 1A, 1
A and 2A are configured. The stirring bars 10, 10 disposed in the cells 1A, 1A in the tube bodies 1, 1 are driven by stirring drive devices 11, 11 installed at the bottom thereof to stir the liquid. 1,1 upper end inlet 1
It is also possible to stir by driving the stirring rod inserted from d and 1d with a motor. In the solute permeation device configured in this way,
A solvent containing the solute to be permeated is injected into one of the cells 1A, 1A from the upper injection port 1d, a solvent to receive the solute is injected into the other, and the annular body 2 is passed through the cell 2A in the center. Hole 2a
A transport carrier complexed with the solute is injected together with the necessary solvent. In this case, a specific solute in the solvent placed in one cell 1A passes through the diaphragm 4, enters the cell 2A, and forms a complex with the transport carrier, and the solute further passes through the other diaphragm 4 to form a complex with the transport carrier. Cell 1A of
will be transferred to. Therefore, only a specific solute can be transferred from one cell 1A where various solutes are present to the other cell, and the specific substance can be concentrated, extracted, or removed. Note that elution and mixing of the solvent between the cells 1A, 2A, 1A can be carried out by adjusting the amount of liquid sample contained in the cells 1A, 1A and adjusting the pressure applied to the pair of diaphragms 4, 4. , can be minimized. According to the present invention, a solvent containing a specific solute, another solvent that accepts the solute, and a carrier for transporting the solute are separated and accommodated by the permeable diaphragm. Therefore, it is easy to increase the concentration of the transport carrier, and thereby efficient extraction, concentration, and removal can be expected through permeation of the solute.Moreover, the storage volume of the transport carrier can be reduced, making it possible to increase the concentration of the transport carrier using conventional equipment. Since the transport route is shorter than that in the conventional method, the device can be made smaller. Also,
In conventional solute permeation devices, it was necessary to use either an H-tube type or a U-tube type device depending on the specific gravity of the solvent, and it was impossible to use it for solvents with similar specific gravities, but the solute permeation device of the present invention It has excellent features such as being able to be used regardless of the specific gravity of the solvent and being extremely easy to handle. Example A permeation experiment was conducted in which a solute contained in solution A was transferred to solution B using the apparatus shown in the drawings. The experimental conditions in this case are as follows. (1) Diaphragm 4, 4 Porous polypropylene film with pores of 0.2 microns, film thickness 25 μm. (2) Solution A (injected into cell 1A of one tube body 1) Contains 0.1M LiOH, 0.1M NaCl and 0.1M Kcl
40ml of a mixed aqueous solution with a pH of approximately 12. (3) Solution B (injected into cell 1A of the other tube 1) 40 ml of an aqueous solution containing 0.1 MH ₃ PO ₄ at pH 1.30. (4) Solute transport carrier solution (injected into cell 2A of annular body 2) A compound represented by the following formula as a solute transport carrier
Solution of 1.5×10 ^-4 mol dissolved in 3 ml of chloroform [Solute transport carrier] Compound name: 1-[3-(o-carboxyphenyloxy)propoxy]-2-[3-
(8-quinolyloxy)propoxy]
-4 (or 5)-t-butylbenzene Structural formula: The results of the above experiment are shown in the following table.

【table】

[Brief explanation of the drawing]

FIG. 1 is a sectional view of an embodiment of the invention. 1A, 2A...Cell, 1...Tube body, 1b...Horizontal tube part, 1e...Opening, 2...Annular body, 4...Diaphragm body.

Claims (1)

[Claims] 1 A pair of substantially L-shaped tubes forming a cell for accommodating a solvent containing a specific solute and a solvent that receives the solute, and between the openings of the horizontal tube portions of the tubes, the above-mentioned A solute permeation device characterized in that a ring-shaped body forming a cell for accommodating a transport carrier that forms a complex with a solute is fastened with a diaphragm body having permeability to the solute arranged on both sides of the ring-shaped body. .