JPS6337669B2 - - Google Patents
Info
- Publication number
- JPS6337669B2 JPS6337669B2 JP56149785A JP14978581A JPS6337669B2 JP S6337669 B2 JPS6337669 B2 JP S6337669B2 JP 56149785 A JP56149785 A JP 56149785A JP 14978581 A JP14978581 A JP 14978581A JP S6337669 B2 JPS6337669 B2 JP S6337669B2
- Authority
- JP
- Japan
- Prior art keywords
- insert
- warmer
- drug
- cancer
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000015 thermotherapy Methods 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 17
- 239000002246 antineoplastic agent Substances 0.000 claims description 13
- 229940041181 antineoplastic drug Drugs 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 230000001093 anti-cancer Effects 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 9
- 206010008342 Cervix carcinoma Diseases 0.000 description 8
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 8
- 201000010881 cervical cancer Diseases 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 238000002512 chemotherapy Methods 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 235000013580 sausages Nutrition 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009217 hyperthermia therapy Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 201000004933 in situ carcinoma Diseases 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229910001120 nichrome Inorganic materials 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Thermotherapy And Cooling Therapy Devices (AREA)
Description
本発明は子宮頚癌等の温熱療法に使用する温熱
療法装置に関する。
癌に対する治療法としては、手術療法、放射線
療法、化学療法および免疫療法があり、近年で
は、温熱療法が試みられ、その臨床成積について
の報告もあり、温熱が正常組織を破壊することな
く、選択的腫瘍組織を破壊することが明らかにな
つた。さらに温熱は腫瘍に対して放射線感受性を
高め、また、制（抗）癌剤の効果を増強させるこ
とも判明している。
ところで、現在、温熱を行なう手段として、全
身温熱療法、局所潅流療法、温水療法、超短波療
法或いは超音波療法などが試みられ、これら各療
法に使用する装置も開発されているが、いずれの
装置も実験段階的なもので、末だ完全なものはな
く、今後の研究により解決しなければならない問
題を有している。
また、上記温熱療法装置は可成り大がかりにな
り、また或る種のものは、たとえば子宮頚癌等、
癌の種類によつては、その温熱療法装置として適
さないものもある。
本発明は上記のような点に着目し、簡易な構成
により、病巣を含む生体の限局した部分を一定の
温度に保持でき、特に子宮頚癌、食道癌或いは直
腸癌などの温熱療法に適した斬新的な温熱療法装
置を提供することを目的とするものである。
本発明は上記の目的を達成するために、耐熱性
を有し、かつ適度の可撓性を有する素材で造ら
れ、適当の径及び長さに形成した挿入体内にヒー
ターとセンサーを内蔵して成る加温器と、該加温
器の温度制御器とより成り、温度制御器により加
温器の温度を自動的に制御させるように構成した
ものにおいて、加温器の挿入体の外周面に制
（抗）癌剤等の薬剤を添着させるように構成した
ものである。
上記本発明によれば、加温器の温熱療法と薬剤
の化学療法の相乗作用によつて患部を治療するこ
とになる。
以下、図面を参照して本発明の実施例につき説
明する。図面は本発明の実施例を示すもので、図
において、ａは加温器を示し、１は耐熱性を有
し、かつ適度の可撓性を有する素材で造られ、適
当の径及び長さに形成した挿入体で、挿入体１内
には先端１ａ側に位置させてニクロム線その他の
ヒーター２とセンサー３が内蔵されている。実施
例の挿入体１は先端１ａを閉塞した管体状に形成
すると共に先端１ａを球面状に形成して治療部位
への挿入を円滑に行なえるように構成してある。
挿入体１の径及び長さは治療する部位に応じて決
めるもので、たとえば子宮頚癌用の場合には、直
径５ミリ程度、長さ250ミリ程度が良い。
上記挿入体１は、可撓性を有する素材で造り、
子宮頚部等の挿入部に合わせて適当に湾曲させる
等、変形性を付与してあるが、同時にまた、挿入
体は子宮頚部等に挿入するものであるため、柔ら
かすぎると挿入を困難にする虞れがある。さらに
また、挿入体１にはヒーター２を内蔵しているの
で、その素材としては絶縁材が好ましい。そこ
で、挿入体１の素材の選択に際しては上記の点を
考慮して決定すれば良く、たとえば、テフロン系
樹脂、シリコン系樹脂あるいはポリプロピレン系
樹脂などが適している。しかしながら挿入体１の
素材は上記に例示したものに限定されるものでは
ない。
また、上記センサー３としては、熱電対、サー
ミスタ、白金電極、ダイオードその他所望のもの
を選択して採用できる。
４は吸盤状等に形成し、挿入体１に摺動自在に
装着したストツパー部材で、該ストツパー部材４
は、治療部所に挿入した加温器ａを所定の位置に
安定して定置させるためのもので、必要に応じて
設ける。５は挿入体１の基端を連結した握部、６
はコードを示し、コード６の先端にはコネクタ７
が取付けてある。
ｂは加温器ａの温度を制御する温度制御器を示
し、温度制御器ｂの前面には、電源スイツチ８、
コネクタ７の差込口９、加温器ａの温度を表示す
る指示計１０、加温器ａの温度を目的の温度に設
定する温度設定用ダイヤルおよび加温器ａが一定
以上の温度になつた時（故障等の原因により）、
報知器で警報し、かつ加温器ａとの回路を遮断さ
せるための温度を設定するダイヤル１２等が設け
てあり、この温度制御器ｂは所望の形式のものを
採用できる。
而して、本発明は上記加温器ａの挿入体１の外
周面に薬剤Ｃを添着させるもので、以下、これに
つき第５図乃至第７図を用いて説明する。
第５図の実施例では、挿入体１の外周面に、ヒ
ーター２の内蔵部分に位置させて抗癌剤、制癌剤
等の薬剤Ｃを塗布或いは吹き付け等により付着さ
せたものである。
また、第６図の実施例では、挿入体１に被嵌さ
せるように構成したテフロン系樹脂、ポリプロピ
レン系樹脂その他で造つた肉薄の被嵌袋１３を設
け、この被嵌袋１３の外周面における所定の位置
（被嵌袋１３を加温器ａに被嵌した際、ヒーター
部に位置する箇所）に抗（制）癌剤等の薬剤Ｃを
塗布或いは吹き付け等の手段により付着させ、こ
の被嵌袋１３を挿入体１に着脱自在に被嵌させる
ように構成してある。
さらにまた、第７図の実施例では、第６図の実
施例と同様の被嵌袋１３を設け、この被嵌袋１３
の外周面における所定の位置（第６図と同じ箇
所）に流出孔１４ａを有する薬剤収容部１４を形
成し、該収容部１４内に抗（制）癌剤等の薬剤
C1（顆粒状）を収容し、この被嵌袋１３を挿入体
１に着脱自在に被嵌させるように構成したもので
ある。
実施例の温熱療法装置は上記のように構成した
もので、次にその使用方法の一例につき、第１図
および第４図を参照して説明する。第４図は子宮
頚癌に使用している例を示したもので、まづ、加
温器ａのコード６のコネクタ７を温度制御器ｂの
差込口９に差込み、電源スイツチ８をONにする
と共にダイヤル１１，１２を回動して加温器ａの
温度、および警報温度を所定値（たとえば、ダイ
ヤル１１を50℃、ダイヤル１２を55℃に）設定す
る（第１図参照）。そして、第４図示のように、
子宮口Ａより、加温器ａの挿入体１（ただし、第
６図、第７図示のものにあつては被嵌袋１３を挿
入体１に被嵌させた状態で）を子宮頚部Ｂに挿入
し、加温器ａのヒーター部を子宮頚部Ｂの中央に
位置させて定置し、加温器ａによる温熱療法と薬
剤による化学療法とを併用して治療するものであ
る。
なお、第６図、第７図の実施例のように構成す
ると、被嵌袋１３のデスポ的使用が可能になる。
次に実験例につき説明する（於；岩手医科大学
部産婦人科学教室）。
実験例 １
本発明の装置（ただし、薬剤は使用せず、以下
同じ）を用い、正常子宮頚部、子宮頚部上皮内
癌、初期浸潤癌、子宮頚癌ｂ期の子宮頚部を加
温した後に子宮を摘出し、その病理組織的変化を
検討して次の結果を得た。
(1) 48.5℃では、癌組織、正常扁平上皮、結合織
はすべてが壊死となつていた。
(2) 45.6℃では、癌組織、扁平上皮基底層は壊死
におちいるが、扁平上皮表層や結合織には類壊
死の像がみられた。
(3) 43.5℃では癌細胞のPyknosisが著じるしい。
また、正常扁平上皮基底層細胞にPyknosis
をみとめたが、表層細胞や間質組織には、特記
すべき変化をみとめなかつた。
実験例 ２
本発明の装置を用い、子宮頚癌温熱療法への基
礎実験を行なつた。すなわち、卵白およびソーセ
ージを用いて子宮頚部のフアントームを作製し、
本発明装置使用時の温度分布を針形熱電温度計に
より測定した。その結果得られたデータは以下に
示す表のとうりであつた。次いで、摘出子宮を用
いて、同様の方法で加温、温度測定を行なつた結
果、フアントームに一致した温度分布が得られ、
子宮頚癌の温熱治療へ本願発明装置を応用できる
ことを示唆する成績が得られた。
以下に示す表は、ソーセージを用いて作製した
フアントームの中心に加温器ａを挿入し、加温器
ａの設定温度を順次変え、加温されるフアントー
ムの温度分布状況を計測して得た温度分布表（摂
氏温度）で各表中のｘ欄は加温器ａのヒーター２
の中心部における挿入体１の外壁面より、フアン
トームの肉厚方向（横方向）への距離（単位ミ
リ）を、ｙ欄は同じくフアントームの軸線方向
（縦方向）への距離（単位ミリ）を示す。
The present invention relates to a thermotherapy device used for thermotherapy for cervical cancer, etc. Treatment methods for cancer include surgery, radiation therapy, chemotherapy, and immunotherapy.In recent years, hyperthermia therapy has been attempted, and there have been reports of its clinical success. It has been shown to selectively destroy tumor tissue. Furthermore, it has been found that heat increases the radiosensitivity of tumors and also enhances the effects of anti-cancer drugs. By the way, currently, as a means of applying heat, whole body thermotherapy, local perfusion therapy, hot water therapy, ultrashort wave therapy, or ultrasound therapy are being tried, and devices for use in each of these therapies have also been developed, but none of the devices are effective. This is still at an experimental stage, and nothing is perfect, and there are problems that need to be resolved through future research. In addition, the above-mentioned thermotherapy devices are quite bulky, and some types of thermotherapy devices are used for treatment of diseases such as cervical cancer, etc.
Depending on the type of cancer, some types of cancer may not be suitable as thermotherapy devices. The present invention focuses on the above-mentioned points, and has a simple configuration that allows a localized part of the body, including a lesion, to be maintained at a constant temperature, and is particularly suitable for thermotherapy for cervical cancer, esophageal cancer, rectal cancer, etc. The purpose is to provide a novel thermotherapy device. In order to achieve the above object, the present invention incorporates a heater and a sensor in an insert made of a heat-resistant and moderately flexible material and formed into an appropriate diameter and length. and a temperature controller for the warmer, and configured to automatically control the temperature of the warmer by the temperature controller, the outer circumferential surface of the insert of the warmer The structure is such that a drug such as an anti-cancer drug is attached thereto. According to the present invention, the affected area is treated by the synergistic effect of thermotherapy using a warmer and chemotherapy using drugs. Embodiments of the present invention will be described below with reference to the drawings. The drawing shows an embodiment of the present invention, and in the drawing, a indicates a warmer, 1 is made of a heat-resistant and moderately flexible material, and has an appropriate diameter and length. The insert body 1 has a built-in heater 2 such as a nichrome wire and a sensor 3 located on the tip 1a side. The insert 1 of the embodiment has a distal end 1a formed in the shape of a closed tube and a spherical shape so that it can be smoothly inserted into a treatment site.
The diameter and length of the insert 1 are determined depending on the site to be treated; for example, in the case of cervical cancer, a diameter of about 5 mm and a length of about 250 mm are suitable. The insert 1 is made of a flexible material,
Although it is given deformability by being appropriately curved to fit the insertion site such as the cervix, at the same time, since the insert is inserted into the cervix, etc., if it is too soft, it may make insertion difficult. There is. Furthermore, since the insert 1 has a built-in heater 2, an insulating material is preferable as its material. Therefore, when selecting the material for the insert 1, the above-mentioned points may be taken into consideration. For example, Teflon resin, silicone resin, polypropylene resin, etc. are suitable. However, the material of the insert 1 is not limited to those exemplified above. Further, as the sensor 3, a thermocouple, a thermistor, a platinum electrode, a diode, or other desired sensor can be selected and employed. Reference numeral 4 denotes a stopper member formed in the shape of a suction cup or the like and slidably attached to the insert 1;
is for stably placing the warmer a inserted into the treatment area at a predetermined position, and is provided as necessary. 5 is a grip portion connecting the proximal end of the insert body 1;
indicates the cord, and the connector 7 is at the tip of the cord 6.
is installed. b indicates a temperature controller that controls the temperature of the warmer a, and on the front of the temperature controller b are a power switch 8,
The insertion port 9 of the connector 7, the indicator 10 that displays the temperature of the warmer a, the temperature setting dial that sets the temperature of the warmer a to the desired temperature, and the temperature of the warmer a that reaches a certain level or higher. (due to malfunction, etc.)
A dial 12 and the like are provided for setting a temperature for issuing an alarm and interrupting the circuit with the warmer a, and the temperature controller b can be of any desired type. According to the present invention, a medicine C is attached to the outer circumferential surface of the insert 1 of the warmer a, and this will be explained below with reference to FIGS. 5 to 7. In the embodiment shown in FIG. 5, a drug C such as an anticancer drug or an anticancer drug is attached to the outer circumferential surface of the insert 1 by coating or spraying so as to be located in the built-in portion of the heater 2. In addition, in the embodiment shown in FIG. 6, a thin fitting bag 13 made of Teflon resin, polypropylene resin, or the like and configured to be fitted onto the insert body 1 is provided, and the outer circumferential surface of the fitting bag 13 is A drug C, such as an anti-cancer drug, is applied to a predetermined position (the part located in the heater part when the bag 13 is fitted into the warmer a) by coating or spraying, and this coating is applied. The fitting bag 13 is configured to be removably fitted onto the insert body 1. Furthermore, in the embodiment shown in FIG. 7, a fitting bag 13 similar to the embodiment shown in FIG.
A drug accommodating portion 14 having an outflow hole 14a is formed at a predetermined position on the outer peripheral surface (same location as in FIG. 6), and a drug such as an anti-cancer drug is contained in the accommodating portion 14.
C 1 (in the form of granules) is accommodated therein, and this fitting bag 13 is configured to be detachably fitted onto the insert body 1 . The thermotherapy apparatus of this embodiment is constructed as described above, and an example of its usage will be described next with reference to FIGS. 1 and 4. Figure 4 shows an example of use for cervical cancer. First, plug the connector 7 of the cord 6 of the warmer a into the socket 9 of the temperature controller b, and turn on the power switch 8. At the same time, dials 11 and 12 are turned to set the temperature of warmer a and the alarm temperature to predetermined values (for example, dial 11 to 50°C and dial 12 to 55°C) (see FIG. 1). Then, as shown in the fourth diagram,
From the cervix A, insert the insert 1 of the warmer a (in the case of the ones shown in FIGS. 6 and 7, the insert bag 13 is fitted onto the insert 1) to the cervix B. The uterine cervix B is inserted into the cervix, and the heater part of the warmer a is placed in the center of the cervix B, and the treatment is performed using a combination of thermotherapy using the warmer a and chemotherapy using drugs. It should be noted that if the configuration is as shown in the embodiments shown in FIGS. 6 and 7, the bag 13 can be used as a disposable bag. Next, an experimental example will be explained (at Iwate Medical University, Department of Obstetrics and Gynecology). Experimental Example 1 Using the device of the present invention (however, no drugs were used, the same applies hereinafter), the cervix of a normal cervix, cervical intraepithelial carcinoma, early invasive cancer, and stage B cervical cancer was heated, and then the uterine cervix was heated. We excised the specimen and examined its histopathological changes, and obtained the following results. (1) At 48.5℃, cancer tissue, normal squamous epithelium, and connective tissue were all necrotic. (2) At 45.6℃, the cancer tissue and the basal layer of squamous epithelium were necrotic, but the surface layer of squamous epithelium and connective tissue showed signs of necrosis. (3) Pyknosis of cancer cells is remarkable at 43.5℃. In addition, Pyknosis occurs in normal squamous epithelial basal layer cells.
However, no noteworthy changes were observed in surface cells or interstitial tissue. Experimental Example 2 Using the device of the present invention, a basic experiment was conducted on thermotherapy for cervical cancer. That is, a cervix fantome is created using egg white and sausage,
The temperature distribution during use of the device of the present invention was measured using a needle type thermocouple. The data obtained were as shown in the table below. Next, we heated and measured the temperature using the same method using the removed uterus, and as a result, we obtained a temperature distribution that matched the phantom.
Results were obtained that suggest that the device of the present invention can be applied to thermal treatment of cervical cancer. The table shown below was obtained by inserting a warmer a into the center of a fan tome made using sausage, sequentially changing the set temperature of the warmer a, and measuring the temperature distribution of the warmed fan tome. In the temperature distribution table (degrees Celsius), the x column in each table is for heater 2 of warmer a.
The distance (in millimeters) in the wall thickness direction (lateral direction) of the phantom from the outer wall surface of the insert 1 at the center of the phantom, and the distance (in millimeters) in the axial direction (vertical direction) of the phantom in the y column. show.
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【表】
以上説明したとおり、本願発明によれば、簡易
な構成により、病巣を含む生体の局所を一定の温
度に保持でき、挿入体は適度の可撓性を有してい
るので、加温器を治療する部位の形状等に合わせ
て適当に変形でき、したがつて、加温器を加温す
る部位にフイツトさせて使用することができ、特
に本発明においては、加温器の挿入体の外周面に
制（抗）癌剤等の薬剤を添着させてあるから温熱
療法と化学療法との相乗作用により治療効果を向
上させることができる。[Table] As explained above, according to the present invention, the local area of the living body including the lesion can be maintained at a constant temperature with a simple configuration, and since the insert has appropriate flexibility, heating is possible. The device can be appropriately deformed according to the shape of the area to be treated, and therefore the warmer can be used by fitting it to the area to be heated. In particular, in the present invention, the insert of the warmer Since a drug such as an anti-cancer drug is attached to the outer peripheral surface of the tube, the synergistic effect of thermotherapy and chemotherapy can improve the therapeutic effect.
図面は本発明に係る温熱療法装置の実施例を示
すもので、第１図は装置全体の概略斜視図、第２
図は加温器の部分を拡大して示す側面図、第３図
は第２図の−線断面図、第４図は使用状態を
示す説明図、第５図乃至第７図は本発明の要部の
夫々別実施例を示す図である。
ａ……加温器、ｂ……温度制御器、Ｃ，C1…
…薬剤、１……挿入体、２……ヒーター、３……
センサー、６……コード、８……電源スイツチ、
９……差込口、１０……指針計、１１，１２……
ダイヤル、１３……被嵌袋、１４……薬剤収容
部。
The drawings show an embodiment of the thermotherapy device according to the present invention, and FIG. 1 is a schematic perspective view of the entire device, and FIG.
The figure is a side view showing an enlarged portion of the warmer, FIG. 3 is a sectional view taken along the - line in FIG. 2, FIG. 4 is an explanatory diagram showing the state of use, and FIGS. FIG. 6 is a diagram showing different embodiments of main parts. a... Warmer, b... Temperature controller, C, C 1 ...
...Drug, 1... Insert, 2... Heater, 3...
Sensor, 6...cord, 8...power switch,
9...Inlet, 10...Pointer gauge, 11, 12...
Dial, 13... fitting bag, 14... drug storage section.
Claims (1)
材で造られ、適当の径及び長さに形成した挿入体
内にヒーターとセンサーを内蔵して成る加温器
と、該加温器の温度制御器とより成り、温度制御
器により加温器の温度を自動的に制御させるよう
に構成したものにおいて、加温器の挿入体の外周
面に制（抗）癌剤等の薬剤を添着させるように構
成したことを特徴とする温熱療法装置。 ２ 制（抗）癌剤等の薬剤の添着手段として、挿
入体の外周面に制癌剤を直接付着させるように構
成したことを特徴とする特許請求の範囲第１項記
載の温熱療法装置。 ３ 制（抗）癌剤等の薬剤の添着手段として、挿
入体に被嵌させるように形成した肉薄の被嵌袋の
外周面に制（抗）癌剤を付着させ、該被嵌袋を挿
入体に着脱自在に被嵌させるように構成したこと
を特徴とする特許請求の範囲第１項記載の温熱療
法装置。 ４ 制（抗）癌剤等の薬剤の添着手段として、挿
入体に被嵌させるように形成した肉薄の被嵌袋の
外周部に薬剤収容部を設けて該収容部内に制癌剤
を収容させ、該被嵌袋を挿入体に着脱自在に被嵌
させるように構成したことを特徴とする特許請求
の範囲第１項記載の温熱療法装置。[Scope of Claims] 1. A warmer comprising a heater and a sensor built into an insert body made of a heat-resistant and moderately flexible material and formed to an appropriate diameter and length. , a temperature controller for the warmer, and configured to automatically control the temperature of the warmer by the temperature controller, wherein an anti-cancer is provided on the outer peripheral surface of the insert of the warmer. 1. A thermotherapy device characterized in that it is configured to be attached with a drug such as a drug. 2. The thermotherapy device according to claim 1, wherein the anti-cancer agent is directly attached to the outer circumferential surface of the insert as a means for attaching a drug such as an anti-cancer agent. 3. As a means for attaching a drug such as an anti-cancer agent, an anti-cancer agent is attached to the outer circumferential surface of a thin bag formed to fit over the insert, and the bag is inserted. 2. The thermotherapy device according to claim 1, wherein the thermotherapy device is configured to be removably fitted onto the body. 4. As a means for attaching drugs such as anti-cancer drugs, a drug accommodating part is provided on the outer periphery of a thin bag formed to fit over the insert body, and the anti-cancer drug is accommodated in the accommodating part. The thermotherapy device according to claim 1, characterized in that the bag is configured to be detachably fitted onto the insert body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14978581A JPS5850959A (en) | 1981-09-22 | 1981-09-22 | Warm heat treating apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14978581A JPS5850959A (en) | 1981-09-22 | 1981-09-22 | Warm heat treating apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5850959A JPS5850959A (en) | 1983-03-25 |
| JPS6337669B2 true JPS6337669B2 (en) | 1988-07-26 |
Family
ID=15482657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14978581A Granted JPS5850959A (en) | 1981-09-22 | 1981-09-22 | Warm heat treating apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5850959A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3490016T1 (en) * | 1983-01-21 | 1985-02-07 | Ramm Associates, Creve Coeur, Mo. | Implantable hyperthermia device and system |
| US6183556B1 (en) | 1998-10-06 | 2001-02-06 | Seh-America, Inc. | Insulating and warming shield for a seed crystal and seed chuck |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5570248A (en) * | 1978-11-24 | 1980-05-27 | Senko Med Instr Mfg | Warmer for thermotherapy |
| JPS55129058A (en) * | 1979-03-29 | 1980-10-06 | Olympus Optical Co | Heater for inside of coelom |
-
1981
- 1981-09-22 JP JP14978581A patent/JPS5850959A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5570248A (en) * | 1978-11-24 | 1980-05-27 | Senko Med Instr Mfg | Warmer for thermotherapy |
| JPS55129058A (en) * | 1979-03-29 | 1980-10-06 | Olympus Optical Co | Heater for inside of coelom |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5850959A (en) | 1983-03-25 |
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