JPS6319283Y2 - - Google Patents

Description

[Detailed description of the invention] The present invention relates to a liquid active substance-containing preparation, in particular,
This invention relates to a sheet or tape-like preparation that can be easily attached to a tree or suspension device as a ring-shaped preparation.

In recent years, as a pest control method that does not cause environmental pollution, so-called mass-mass treatment has been developed, in which preparations containing insect sex pheromone are sprayed outdoors, and the pheromone is released into the atmosphere to attract insects to traps and kill them. - Trapping methods and so-called disturbance methods that disrupt males' ability to sense females and engage in mating behavior are attracting attention. As preparations for this purpose, products with various structures are conventionally known, but
In many cases, they are cut into predetermined shapes and dimensions and individually attached to trees with threads, strings, etc., which requires considerable effort to apply.

This invention was made in view of the above, and
The purpose of the present invention is to provide a sheet-like or tape-like preparation containing an active substance such as a pheromone, which can be easily attached to a tree or the like.

The active substance-containing preparation according to the present invention has a hole in one end of the sheet-like or tape-like preparation containing the active substance, and a locking member that is removably inserted into and engaged with the hole in the other end. It is characterized by a joint being formed.

The sheet-like or tape-like preparation according to the present invention (hereinafter simply referred to as sheet-like preparation) is not particularly limited in its structure; Although preparations in which the active substance is impregnated to form a storage layer, which is wrapped in a polymer membrane capable of controlling the release of the active substance and heat-sealed at the periphery, may also be used, it is preferable to use a plurality of independent microorganisms. A sheet-like preparation is used that consists of a porous polymer layer having pores and a liquid active substance that has limited solubility in the polymer at room temperature and is encapsulated as droplets in the micropores.

The sheet-like preparation as described above preferably comprises, for example, a polymer and an active substance that is liquid at room temperature and has limited solubility in the polymer at room temperature.
Both the active substance and the polymer are dissolved in an organic solvent that is both soluble and more volatile than the active substance, this solution is applied to the surface of a suitable support, the solvent is evaporated, and the above-mentioned It is manufactured by dispersing a liquid active substance in the form of minute droplets within a layer of polymer. In the above, the liquid active substance is dispersed as droplets in the polymer layer during preparation of the formulation, and is added to the polymer so that it is released from the polymer layer at a substantially constant rate after formulation. It is blended in an amount that exceeds the solubility.

In the present invention, a liquid active substance refers to a substance that is liquid at room temperature and has chemical or physiological activities such as attractant activity, pesticide activity, repellent activity, and aromatic activity, and is particularly effective in pest communication as described above. When used as a disturbance preparation, pheromone with attractant activity, such as Z-11 tetradecenyl acetate,
Z-9-tetradecenyl acetate, E-11-tetradecenyl acetate, Z-9-dodecenyl acetate, 10-methyldodecenyl acetate, 11-
Dodecenyl acetate and the like are preferably used.
Specific examples of other active substances include, for example:
As pesticide active substances, insecticides such as Naled, Diazinon, Sumithion, β
- Disinfectants such as propiolactone, repellents such as triethylene glycol monohexyl ether, N,N-diethyl-m-toluamide, limonene, benzyl alcohol, esters and ethers derived from hydrocarbons having 6 to 16 carbon atoms and aromatic substances such as aldehydes.

The polymer for forming the above-mentioned porous polymer layer needs to have limited solubility for the liquid active substance used as described above, and usually the liquid active substance is contained in a range of 5 or less polymerized parts. A polymer that can be dissolved only in an amount of 0.01 to 2 parts by weight is preferably used. Such polymers are appropriately selected depending on the liquid active substance used, and specific examples include polysulfone, polycarbonate, polystyrene, poly(meth)acrylic acid ester including polymethyl methacrylate, polyamide, and polyvinylidene chloride. , polyvinylidene fluoride, cellulose ester, regenerated cellulose, polyurethane, polyvinyl alcohol, polyvinyl chloride, polyvinyl acetate, ethylene-vinyl acetate copolymer, vinyl chloride-vinyl acetate copolymer, polystyrene-polybutadiene block copolymer, etc. One type or a mixture of two or more types can be mentioned.

In addition, the organic solvent used in manufacturing the preparation according to the present invention must be able to dissolve both the active substance and the polymer, be more volatile than the active substance, and have a lower boiling point. and the type of polymer, but specifically, for example, methylene chloride, chloroform,
Lower aliphatic halogenated hydrocarbons such as carbon tetrachloride,
In addition to lower aliphatic alcohols such as methanol and ethanol, and their acetate esters, one or a mixture of two or more of acetonitrile, acetone, ethyl ether, tetrahydrofuran, etc. can be used. In particular, lower aliphatic halogenated hydrocarbons such as methylene chloride are preferably used.

The concentration of the total amount of liquid active substance and polymer in the solution containing them is usually between 10 and 40% by weight.
is suitable, preferably 15 to 30% by weight.
After this solution is applied onto a suitable support such as a resin film, metal foil or thin sheet, or a laminate thereof, the organic solvent is removed by evaporation.

The temperature when evaporating the organic solvent is usually 0 to 0.
The temperature is 100°C, preferably in the range of 15 to 70°C, and below the boiling point of the solvent. Normally, it may be at room temperature, but it may be heated if necessary. Also,
It may also be evaporated under reduced pressure. In this way, as the organic solvent is evaporated, the liquid active substance has only a limited solubility in the polymer and the active substance is contained in an amount exceeding the solubility in the polymer. Phase separation occurs between the
The tiny droplets of active substance are uniformly dispersed in the polymer matrix, so that the polymer forms a porous layer with a large number of independent micropores within which the liquid active substance is encapsulated. The Rukoto. Normally, on the surface of a polymer, the concentration of the polymer increases as the solvent evaporates, and eventually a dense thin layer is formed on the surface of the porous layer, which is integrated with the porous layer. If the evaporation is carried out in a humid atmosphere, it is usually possible to obtain a homogeneous porous membrane without a dense thin layer on the surface.

In the sheet-like preparation obtained by this method, the micropores formed in the porous polymer layer are usually independent pores separated by partition walls with a thickness of 0.1 to 5 μm, and the pore diameter is 0.5 to 5 μm. It is about 10μ. In addition, since the porous polymer layer has a porosity of about 30 to 80%, it can contain up to about 70% by weight of the liquid active substance, but in practical terms, the maximum is about 50% by weight. is appropriate. Further, the thickness of the porous polymer layer is not limited in any way, but is usually in the range of 10 to 500μ.

In the above-mentioned sheet-like preparation, the liquid active substance encapsulated within the pores of the polymer layer has limited solubility in the polymer, so diffusion into the polymer is suppressed. Thus, the liquid active substance is released at a controlled rate so that release into the ambient atmosphere is limited.

If necessary, a polymer film having a lower diffusivity for the liquid active substance than the polymer layer is laminated on the porous polymer layer to serve as a control layer for controlling the rate of release of the active substance into the environment. be able to. Generally, a film made of polyethylene or polyethylene terephthalate is preferably used for such a control layer.

It is also possible to laminate a backing on the back side of the polymer layer that does not substantially allow the active substance to diffuse through, so that the active substance can be released only from one side of the sheet-like preparation. As such backing, for example, a metal foil, a thin sheet, a resin film, or a laminate thereof is used. Therefore, the above-mentioned base material can also be used as a backing as it is.

In the sheet-like preparation according to the present invention, a hole is bored at one end, and the other end is removably inserted into the hole to engage and connect the ends. A joint is provided, and the ends are thus interconnected to form a ring and suspended on a tree branch or the like.

FIG. 1 shows an enlarged sectional view of essential parts of an embodiment of the sheet-like active substance-containing preparation 1 according to the present invention, in which the porous polymer layer 2 has a large number of independent micropores 3, and the micropores are A liquid active substance 4, for example, a pheromone, is sealed, and a backing 5 is laminated on the back side as required.

FIG. 2 is a perspective view showing a preferred embodiment of the preparation according to the present invention, in which a hole 6 of an appropriate size is bored at one end of the preparation 1, and a hole 6 of an appropriate size is bored at the other end of the preparation 1. The engaging portion 10 consists of a narrow neck portion 8 formed by partially cutting out both side edges 7 in the width direction, and a wide head portion 9 that continuously extends from the neck portion toward the end of the preparation. It is formed.

FIG. 3 shows another more preferred embodiment, in which the corners of the wide head 9 constituting the engaging portion 10 are notched so that the engaging portion is configured to be easily inserted into the hole 6. I'm here. Additionally, if the hole or engaging portion provided in the drug product has sharp corners, the drug product may tear from the corner when it is pulled in the longitudinal direction, for example. The embodiment shown in the figure eliminates this possibility, and the hole 6,
Both the neck part 8 and the head part 9 are formed so that their peripheral edges are rounded. Moreover, by forming in this way, the engaging portion can be easily inserted into the hole.

Further, FIG. 5 shows another embodiment in which, instead of forming a neck by cutting out from both side edges of the preparation, cuts 11 are provided in the width direction from both side edges of the preparation to form an engaging part 1.
0 is formed.

FIG. 6 is a perspective view showing an example of the use of the preparation according to the present invention for the preparation shown in FIG. The preparation is connected in an annular manner by inserting it and engaging the head 9 of the engaging part with the hole so that the head does not easily separate from the hole,
The preparation of the present invention may be connected in a ring shape in this way and then attached to a tree branch, or it may be wrapped around a tree branch and connected at both ends to form a ring shape.

In addition, when the preparation has backing 5, when using it, as shown in FIG. Connecting. This is because the polymer layer containing the active substance is shielded from direct sunlight by the backing, thereby preventing deterioration and decomposition of the active substance.

As described above, the sheet-like preparation of the present invention has an engaging portion that can be removably inserted and engaged with a hole drilled at one end of the preparation, and the preparations are interconnected at the end. Therefore, the preparation can be made into a ring and easily attached to trees, etc. Further, since the connecting portion can be easily separated by removing the head from the hole, the preparation once attached to a tree branch or the like can be easily removed as necessary.

Moreover, when the formulation of the present invention has the above-mentioned preferred structure, the liquid active substance has limited solubility in the carrier polymer;
The liquid active substance in the micropores is inhibited from diffusing into the carrier polymer and is therefore released into the ambient atmosphere at a substantially constant rate.

[Brief explanation of the drawing]

FIG. 1 is a sectional view of a main part showing an embodiment of the preparation according to the present invention, FIGS. 2 to 5 are perspective views, and FIG. 6 is a perspective view showing an example of use. 1... Sheet-like preparation, 2... Porous polymer layer,
3... Micropore, 4... Liquid active substance, 5... Bucking, 6... Hole, 8... Neck, 9... Head, 10
...Engagement part.

Claims (1)

[Claims for Utility Model Registration] (1) A porous polymer layer having a large number of independent micropores, which has limited solubility for the polymer at room temperature, and is enclosed in the micropores as droplets. A hole is formed at one end of a sheet-like or tape-like preparation consisting of a liquid active substance, and an engaging part is formed at the other end to be removably inserted into and engaged with the hole. An active substance-containing preparation characterized by: (2) Practical use characterized in that the engaging portion consists of a narrow neck formed by cutting out from the side edge of the preparation, and a wide head that continuously extends from the neck toward the end of the preparation. An active substance-containing preparation according to claim 1 of the patent registration claim. (3) Claims 1 or 2 for utility model registration characterized in that the liquid active substance is a pheromone.
Active substance-containing preparations as described in Section.