JPS63158065A - Catheter for detecting tumor - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention relates to a catheter for detecting tumors, which is said to be useful for self-diagnosis of lesions in the rectum, sigmoid colon, etc., and has a catheter that injects air after being inserted into the affected area. This invention relates to a catheter that is inflated by the following conditions and is configured to photograph the shape of the affected area.

(Conventional technology) With the recent development of preventive medicine, most cases of gastric cancer are detected at an early stage, but the number of cases of colon cancer is comparable to that of lung cancer, and is said to be about half of that of stomach cancer. However, only 7.5% of gastric cancers are detected early, and awareness is still low. This is because 1) patients do not seek medical attention even if they have symptoms due to psychological factors or ignorance of the disease, and 2) complete medical checkups. This is because colon cancer tests are not normally performed during health checkups, but colon cancer tests are performed using the fecal occult blood test, digital rectal examination, colonoscopy, and colonography. It is said that this is because the psychological burden on patients other than ■ is large, and there are few patients.

The most common methods for detecting this colorectal cancer are the above-mentioned digital rectal examination and colonoscopy, and colonography is said to be useful for discovering comorbid lesions and determining the presence or absence of colonic lesions. In this colonography test, if the intestinal cleansing is insufficient, the diagnostic accuracy will be significantly reduced, so it is usually necessary to restrict food for one to two days before the test, and this contrast test also requires a 300~400C, Inject the barium contrast agent (c), change the patient's body position so that the barium reaches the flexure and transverse colon, then pump air, and repeat the position change so that it covers the intestinal wall evenly. There are disadvantages in that it is necessary to perform imaging after the barium is deposited, and the subject is required to excrete the injected barium after the test is completed.

For this reason, efforts are being made to develop test devices of this type that allow patients to perform self-diagnosis by themselves, but none have yet been found to be satisfactory.

(Structure of the Invention) The present invention relates to a tumor detection catheter that can meet such demands, and this catheter has a hollow core body having an air outlet hole, and a contrast agent that is expanded by the extracted air is mixed into the outside of the hollow core body. It is characterized in that it is provided with a rubber-like hollow elastic body made from a rubber composition.

That is, as a result of various studies on catheters for examining rectal tumors, the present inventors found that a rubber-like hollow elastic body made from a rubber-like composition mixed with a contrast agent that can be expanded by air injection has been developed. If you insert this into the rectum through the anus and then blow air into this elastic body, this elastic body will expand and adhere to the rectal wall, so if there is a tumor on the rectal wall, this elastic body will Because the elastic material is mixed with a contrast agent, we discovered that the presence of a tumor can be easily confirmed by directly viewing the X-ray or taking a photograph after inserting this elastic material. The shape of the hollow elastic body,
The present invention was completed by conducting research on the structure, type of contrast agent, amount added, etc.

The rubber-like hollow elastic body constituting the catheter of the present invention must be made of a material that expands when air is introduced, and therefore, it may be made of, for example, vinyl chloride resin, polyethylene,
Thermoplastic resins, such as polypropylene, nylon, etc.
Natural rubber or NBR, SR, EPDM, IR, CR,
It may be made of synthetic rubber such as silicone rubber, but since this is a pharmaceutical product and requires a material with high expansion power, it should be made of natural rubber or silicone rubber. It should be noted that this device is inserted into the rectum through the anus for early screening of rectal tumors, for example.
Before use, the diameter is 10-20m, the length is 100-500m,
The film thickness is 5o~300μI and the diameter is 40~50m when expanded.
It is often made to have a membrane thickness of 30 to 100 μm, and to fit well against the inner wall of the rectum.It is sealed at the end, has a hole in the middle for air supply, and The end of the tube should be fitted with a check valve, cock and air pump.

The rubber-like hollow elastic body for this catheter is inflated by air, so it is said to be placed outside a hollow core body with an air outlet, but this is made of a rubber composition in which a contrast medium is evenly mixed and dispersed. It must be formed from This hollow core body may be hard, but since this catheter is inserted into the human body, it is often soft, and therefore it is made of rubber or plastic. Usually, it is made of the same natural rubber or silicone rubber as the above-mentioned rubber-like hollow elastic body disposed on the outside. Also,
Since this contrast agent is not administered orally into the body, it is not limited to barium sulfate and amidodorizoic acid, which have been conventionally specified for use in the gastrointestinal tract.
This may be anything that is conventionally known and suitable for X-ray imaging, without being limited to those that are not absorbed into the gastrointestinal tract. oil, iodized oil-based X-ray modeling agents such as iodized poppy oil fatty acid ethyl ester (1 content: 480 μ/Q), a liquid mixture of iopidol and iopidone (for example, the product name Hytrust), propiotone (for example, the product Short pyridone X-ray contrast agents such as Dionozil,
Iofengirade for injection, iovanoic acid, iobodate sodium, tylobanoate sodium, sodium acetrizoate, azibioton meglumine, iothalamate sodium, iothalamate meglumine, iodomide meglumine, iodorimide sodium meglumine, amitodorizoic acid, amitodorizoate meglumine , sodium amitodorizoate meglumine, iodophenyl X-ray contrast agents such as iocalmic acid, metrizoic acid, and iobenzamic acid, barium sulfate (powder: brand name Baritone, fluid liquid: brand name Ryubarisol), etc. as defined in the Japanese Pharmacopoeia. Among these, barium sulfate and bismuth subcarbonate (BiHCO) are preferred. The contrast agent may be mixed and dispersed into the rubber composition by a conventional method such as roll kneading, kneading, extrusion, etc., but the amount of the contrast agent mixed in is 10 parts per 100 parts by weight of the rubber composition. If the amount is less than 50 parts by weight, the contrast hardening will be poor, and if it is more than 50 parts by weight, the elasticity of the resulting elastic body will be impaired and it will not fit closely to the intestinal wall, so the amount is preferably in the range of 10 to 50 parts by weight.

The catheter of the present invention constructed as described above is inserted, for example, into the anus, but if there is residual stool during this use, it may lead to a misdiagnosis. Preferably, a glycerin enema of about 100 c.c.

In this process, after such pretreatment, the test subject inserts this catheter into the anus by himself or herself in the toilet, etc.
After inserting this until the digitorum.

When air is pumped into this using a manual pump or the like to inflate the catheter itself and bring it into close contact with the intestinal wall, if a tumor is present in this intestinal area, the contrast medium will be absorbed into the rubber-like hollow elastic body that makes up this catheter. The irregularities of this tumor are clearly formed by the layer containing the contrast agent, so at this point the doctor or the X-ray machine placed there or in a separate room The operating technician only has to operate the catheter and take a picture of it, then activate the manual pump as necessary to reduce the pressure in the catheter and remove it, and the work is completed. is alone,
An example of this embodiment will now be described with reference to the accompanying drawings. FIG. 1 shows a longitudinal cross-sectional view of the catheter of the present invention before use. This catheter is made of room-temperature curable silicone rubber TSE-3221 (trade name manufactured by Toshiba Silicone ■) and has a rubber stopper 1 at the top. It is sealed with an air outlet 2 in the middle, has an inner diameter of 8m+, an outer diameter of 12m, and a length of 300mm.
Silicone rubber TSE-2575 (product name manufactured by Toshiba Silicone ■) is placed on the outside of the mm silicone rubber tube 3.
A rubber-like hollow elastic body 4 made of a silicone rubber composition in which 10% by weight of barium sulfate as a contrast agent is uniformly mixed and dispersed is disposed across a cavity 5, and this silicone rubber tube 3 At the other end is an air check valve 6,
A manual or automatic air pump 8 having a cock 7 is provided, and a grip 9 made of silicone rubber is attached to the lower part of the tube 3. FIG. 2 shows a longitudinal cross-sectional view of the catheter shown in FIG. 1 when it is in use (inflated). Insert this into your own diagnostic part, for example, the anus, until the grip part 9 comes into close contact with the anus 11 of the human body 10, and then operate the manual air pump 8 to send air to this silicone rubber tube 2. Outlet 2
The rubber-like hollow elastic body 4 expands as shown in FIG. 2 due to the air flowing into the cavity 5 through the
Since this comes into close contact with the intestinal wall 13, if a tumor 14 is formed on the intestinal wall 13 of the human body 10, it will become the expanded body 1 of the rubber-like hollow elastic body 4 filled with a contrast medium.
Its shape is clearly captured by the outer skin of No. 2, and this shape is reliably photographed by X-ray photography.

Therefore, by using the catheter of the present invention, a patient suspected of having a lesion in the rectum, etc., can be treated in a separate room of a hospital equipped with X-ray equipment without the need for help from others.
This insertion work can be done by oneself, and the doctor can easily make a diagnosis using this photographed film, so it is easy and reliable without any psychological burden on the patient. This gives the advantage of being able to diagnose tumors in the rectum and large intestine.

Note that although the case of the rectum and large intestine has been described above, this can also be used for detecting tumors in the esophagus, uterus, stomach, bladder, etc.

[Brief explanation of the drawing]

FIG. 1 is a longitudinal sectional view of the catheter of the present invention before use, and FIG.
The figure shows a longitudinal cross-sectional view of the device during use (inflated). 1... Plug, 2... Hole. 3... Silicone rubber tube, 4... Rubber-like hollow elastic body, 5... Cavity, 6... Check valve, 7... Cock. 8... Manual air pump, 9... Gripping part. 10...Human body part, 11...Anus part. 12... Expanded body, 13... Intestinal wall, 14... Tumor. Figure 1

Claims (1)

[Claims] 1. Tumor detection, characterized in that a rubber-like hollow elastic body made of a rubber composition mixed with a contrast agent that expands with the drawn-out air is disposed on the outside of a hollow core body having an air outlet hole. catheter.