JPS63152564A - Various packaged medicine - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention is applicable to PTP packaging materials, particularly for liquid or semi-solid materials such as fluids, wet solids or semi-solids, hygroscopic substances, and materials susceptible to moisture. The present invention relates to various packaging preparations using PTP packaging material suitable for various preparations containing hygroscopic substances.

(Prior Art) PTP packaging (press-through-punk) is widely used for packaging tablets, confectionery, cooking ingredients, and the like. this is,
A polyvinyl chloride ring molded by molding the contents (
The back side of the pristar member (hereinafter referred to as the pristar member) is heat-sealed with aluminum foil or coated aluminum foil (hereinafter referred to as the seal member).

(Problems to be Solved by the Invention) However, the sealing member's aluminum foil and coating aluminum foil have low moisture-proof reliability due to pinholes, etc., and the pristar member's polyvinyl chloride has relatively high moisture permeability. (For example, the moisture permeability of hard polyvinyl chloride with a thickness of 30 μm is 29 to 34 g/w”/24 hr.)
, PTP when the contents are fluids, solid or semi-solid substances (jelly, gel, etc.), hygroscopic substances, substances susceptible to moisture (tablets, drops, etc.), etc.
There was a problem with the packaging material. In other words, corrosion of the aluminum foil of the sealing member and/or discoloration or deterioration of the contents may occur, and especially if the contents are liquid drugs or hygroscopic tablets, decomposition, discoloration, solidification, deliquescence, etc. may occur, and the drug may deteriorate. Until now, it has been provided in a metal-puncture form (a tablet sandwiched between aluminum foil laminated with polyethylene film on both sides and then heat-sealed) to prevent its efficacy and efficacy from being compromised. However, since metal bags cannot observe the contents from the outside, they have had problems such as the inability to detect abnormalities in the contents of special preparations.

Furthermore, drugs with fluidity that have been developed in recent years are
In the case of drug-containing Kyokyu bandage sealed in TP packaging (for example, see JP-A No. 61-22451), not only conventional aluminum foil but also coated aluminum foil can be used.
Accelerated test [40°C] when used as a sealing member for TP packaging
For example, even when using coated aluminum foil,
Because the coating layer often has pinholes and cracks and is not substantially non-porous (this is easily confirmed by scanning electron microscopy), chemicals that seep through the coating layer can corrode the aluminum foil over time. , and may cause discoloration or deterioration of the contents.

(Means for Solving the Problem) The present inventor has proposed that the content may be a liquid or hygroscopic substance such as a fluid, a wet solid or semi-solid, a hygroscopic substance, or a substance susceptible to moisture. As a result of intensive research into PTP packaging materials that do not cause corrosion of the sealing material or discoloration, deterioration, solidification, deliquescence, precipitation, etc. of the contents, we have developed a sealing material laminated with thermoplastic resin, as well as sealing materials and
The present invention was completed based on the discovery that a PTP packaging material in which both pristar members are laminated is very suitable for packaging the liquid or hygroscopic substances and satisfies various conditions.

That is, a seal member laminated with thermoplastic resin,
For example, with aluminum foil, cellophane, and paper (including synthetic paper), the thermoplastic resin forms a substantially non-porous membrane, so the sealing member may corrode or the contents may discolor, change in quality, harden, deliquesce, or Precipitation does not occur (corrosion resistance/moisture resistance). Moisture resistance becomes even more remarkable when thermoplastic resin is laminated to polyvinyl chloride, acetate, or polystyrene ring-ringed pristar members. In addition, the laminated sealing member is easy to seal with the pristar member and has appropriate strength (sealing suitability).The sealing suitability is also the same or different thermoplastic resin used for laminating the sealing member on the pristar member. It is particularly preferable when laminated, and furthermore, in these cases there is no difficulty in taking out the contents (easy removal), but it is most preferable when the sealing member is made of aluminum foil.

The lamination process used in the present invention may be either normal adhesive lamination process (wet type, dry type or heat-melt lamination process) or extrusion lamination process, but it is important to note that the thickness of the laminate film can be easily thinned. Extrusion lamination is particularly preferred because it eliminates the need for processes such as evaporation of solvents and diluents, and drying.

The thermoplastic resin may be of any type, such as vinyl resin, polyester resin, cellulose ester resin, etc., but for extrusion lamination, resins with relatively high melt viscosity, such as polyethylene (especially low density polyethylene [density 0.9
1 to 0.93 polyethin]) Product name: "Sumikasen" (registered trademark - Sumitomo Chemical), "
"Mirason" (registered trademark - Mitsui Polychemicals), "Yukalon" (registered trademark - Mitsubishi Yuka), "rNUc polyethylene" (registered trademark - Nippon Unicar), "Asahi Dow polyethylene" (trademark - Asahi Dow), "rUBE polyethylene"
(registered trademark - Ube Industries), "Betrocene" (registered trademark - Nippon Polychemical), etc. Polypropylene product name: "Mitsubishi Noblen" (registered trademark - Mitsubishi Yuka)
, "Mitsui Noblen" (trademark - Mitsui Toatsu Chemical), "Chinsoboripro" (registered trademark - Chisso Petrochemical), etc. Ionomer product name: "Surlyn AJ (registered trademark - DuPont) etc." Ethylene copolymer product name: "``Erbafuchs'' (registered trademark - DuPont) and the like are preferred. Further, it is preferable that the thickness of the thermoplastic resin laminated onto the sealing member is 5 to 30 μm from the viewpoint of easy removal.

(Function) In various packaging preparations using the laminated PTP packaging material of the present invention, the laminated thermoplastic resin prevents contents such as fluid from infiltrating into the sealing member or water vapor in the outside air from infiltrating into the interior. This not only prevents corrosion of the sealing member and deterioration of the contents, but also allows the contents to be observed from the outside.

(Example) Hereinafter, an example of various packaging preparations using the laminated PTP packaging material of the present invention will be described according to the drawings.
The present invention is not limited to this.

Fig. 1 is a cross-sectional view of a drug-containing emergency bandage, where ■ is an adhesive sheet with a pad 2 attached, a drug 3 is attached to the upper part of the band, and a pristar part on which a drug coating film 5 and an I + release receipt 4 are arranged. It is contained within the space formed by 6 and 6. The pristar portion 6 is provided with a concave projection 8, and one end of the adhesive sheet 1 is provided with a separator 7 for making the release sheet easier to peel off.

Here, the release sheet 4 and the drug coating film 5 are packaged in PTP. As shown in FIG. 2, the drug coating film 5 has a thickness of about 2
0 μm aluminum foil 9 is extruded and laminated with low density polyethylene 10 having a thickness of 15 μm, and as shown in FIG. 3, the release sheet 4 has a thickness of about 2
Low density polyethylene 1 with a thickness of about 50 μm is placed on the back side of the polyvinyl chloride 11 with a thickness of 00 μm (the side facing the drug coating film).
0 was extruded and laminated and molded. The drug coating film 5 and the release sheet 4 were bonded together by heat sealing.

The medicine 3 contained in the above-mentioned emergency bandage may be any external medicine, such as sterilizing disinfectants such as chlorhexidine gluconate, benzalkonium chloride, chlorhexylenol, acrinol, thianthol, dequalinium chloride, sulfamine, sulfamine, These include nitrofurazone, boric acid, homosulfamine, triclocarpane, etc.; zinc oxide, pyridoxine hydrochloride, tocopherol acetate, pyridoxine cibalmitate as agents for promoting wound convergence; anti-inflammatory agents such as nahazoline hydrochloride, zinc sulfate, ephedrine hydrochloride, etc. as hemostatic agents. Examples of agents include steroids such as prednisolone, dexamethasone, and cortisone acetate; glycyrrhetinic acid and lysozyme chloride; and antihistamines such as chlorpheniramine maleate and diphenhydramine hydrochloride. In addition, acupuncture is used as a topical narcotic,
Examples include ethyl aminobenzoate, procaine hydrochloride, dibucaine hydrochloride, tecaine hydrochloride, and diethylaminoethyl valbutylaminobenzoate hydrochloride.

The above-mentioned drug-containing emergency bandage using the laminated PTP packaging material of the present invention contains multiple numbers of the above-mentioned drugs as a compounded drug, but it was sealed for more than 6 months under the accelerated test conditions specified by the Ministry of Health and Welfare. It was confirmed that the components did not corrode, and the encapsulated drug did not change color, precipitate, or change the blending ratio. On the other hand, with aluminum foil and coated aluminum M (including those coated thickly such as 3 coats), the contents and aluminum parts have already discolored after 1 month, and furthermore, after 5 months have passed, the amount of It was confirmed that the blending ratio of the contents changed and the overall weight decreased.

The laminated drug coating film 5 is a blister-6
was easily destroyed by pressing with a finger, and the drug 3 was smoothly transferred to the pad 2.

(Effects of the Invention) As described above, various packaging preparations using the laminated PTP packaging material of the present invention prevent the contents from corroding the sealing member and the contents from discoloration, deterioration, solidification, deliquescence, weight change, etc. can be observed from the outside.

Furthermore, it has good sealability and is easy to take out the contents. Therefore, when the contents are liquid or hygroscopic substances such as fluids, wet solids or semi-solids, hygroscopic substances, substances susceptible to moisture, etc., it is an excellent packaging material that can be used in a wide range of fields. is available.

[Brief explanation of the drawing]

Figure 1 is a sectional view of a drug-containing emergency bandage using the laminated PTP packaging material of the present invention, and Figures 2 and 3 are
The figures are enlarged cross-sectional views of a drug-coated membrane and a blister, respectively. 1.Adhesive sheet 2.Pad 3.Drug 4.Release sheet 5.Drug coating film 6.Blister 9.Hard aluminum foil lO.Low density polyethylene 11.Polyvinyl chloride

Claims (2)

[Claims] (1) Various packaging preparations characterized by using a PTP packaging material laminated with thermoplastic resin as a sealing member. (2) Various packaging preparations according to claim 1, characterized in that a PTP packaging material in which a thermoplastic resin is laminated as a pristar member is used.