JPS63139122A - Defoaming of high-viscosity plaster such as cataplasma or the like - Google Patents
Defoaming of high-viscosity plaster such as cataplasma or the likeInfo
- Publication number
- JPS63139122A JPS63139122A JP28747786A JP28747786A JPS63139122A JP S63139122 A JPS63139122 A JP S63139122A JP 28747786 A JP28747786 A JP 28747786A JP 28747786 A JP28747786 A JP 28747786A JP S63139122 A JPS63139122 A JP S63139122A
- Authority
- JP
- Japan
- Prior art keywords
- plaster
- parts
- doctor knife
- roll
- rotating roll
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011505 plaster Substances 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 claims description 8
- 238000004898 kneading Methods 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 6
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 6
- 229950008882 polysorbate Drugs 0.000 description 4
- 229920000136 polysorbate Polymers 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 3
- 239000005844 Thymol Substances 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229960001047 methyl salicylate Drugs 0.000 description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 229960000790 thymol Drugs 0.000 description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は、高粘度でかつ粘着性の強いパップ剤等の膏体
に含まれる気泡を除去する方法に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for removing air bubbles contained in a highly viscous and highly adhesive plaster such as a poultice.
現在のパップ剤は、膏体の粘着性が改善され、皮膚に密
着し一定時間貼付後剥離しても残置のないものと、従来
どおり粘着力の劣るものとが共存している。いずれの製
品も液剤および粉剤を所定の割合で均一に混練して膏体
をつくり、これを不織布等の支持体上に均等に展延して
製造される。Current poultices coexist with those that have improved adhesiveness and stick closely to the skin and leave no residue even after being applied for a certain period of time and are peeled off, and those that have poor adhesive strength as before. All products are manufactured by uniformly kneading a liquid agent and a powder agent in a predetermined ratio to form a paste, and then uniformly spreading this onto a support such as a nonwoven fabric.
膏体の混線時には、気化した揮発成分や気体が膏体内に
巻込まれ、気泡を形成する。放置することにより消滅す
るのは極く表面近くの比較的大きな気泡に限られ、小気
泡の多くは高粘質のため膏体内に残留する。もしこのよ
うな気泡を含む膏体を支持体上に展延し、プラスチック
フィルムで被覆後適当な寸法に裁断し、成形パップ剤と
したならば、フィルム面がアバタ状となって見掛けが悪
く、また皮膚に接着しない場所が生じ、製品価値が低下
する。When the plaster cross-wires, vaporized volatile components and gases are drawn into the plaster and form bubbles. When left alone, only relatively large bubbles near the surface disappear, and many of the small bubbles remain in the plaster because they are highly viscous. If such a foam-containing paste is spread on a support, covered with a plastic film, and then cut to an appropriate size and made into a molded poultice, the surface of the film becomes avatar-like and looks bad. In addition, there are areas where the adhesive does not adhere to the skin, reducing the product value.
これまで膏体内の気泡を除去する方法としては、混練時
または混線後減圧する方法のほか、膏体を細口のノズル
より噴出させる方法等がある。前者は膏体内の揮発性有
効成分が揮散するので含量が低下し、後者は装置が高価
であるほか高粘度の膏体を処理する場合能率が低い。Conventional methods for removing air bubbles within the plaster include a method of reducing the pressure during kneading or after mixing, and a method of jetting the plaster from a narrow nozzle. In the former, the volatile active ingredients in the plaster evaporate, resulting in a decrease in content, while in the latter, the equipment is expensive and efficiency is low when treating a highly viscous plaster.
そこで本発明は、比較的簡単な装置を使用し、能率よく
高粘度の膏体を脱泡する方法を提案する。Therefore, the present invention proposes a method for efficiently defoaming a highly viscous plaster using a relatively simple device.
本発明は、所定成分を練合して得られた、気泡を含むパ
ップ剤等の高粘度膏体を支持体に展延する前に、該膏体
を回転ロールと、該回転ロール表面と微小間隔を形成す
るように設置した静止ドクターナイフとの間に形成され
たスリットを通過させることによって膏体に含まれる気
泡を除去した後、脱泡された膏体を前記回転ロールから
掻き取ることを特徴とするパップ剤等の高粘度膏体の脱
泡方法である。In the present invention, before spreading a highly viscous paste such as a poultice containing air bubbles obtained by kneading predetermined ingredients onto a support, the paste is transferred between a rotating roll and a surface of the rotating roll and microscopically. After removing the air bubbles contained in the plaster by passing it through a slit formed between the plaster and a stationary doctor knife installed to form a gap, the degassed plaster is scraped off from the rotating roll. This is a method of defoaming high viscosity plasters such as poultices.
図面は本発明方法を実施するための装置の概略図である
。実験に使用した装置では、回転ロール１は直径約１０
ｃｍ、長さ約１ｍの鋼鉄製である。The drawing is a schematic diagram of an apparatus for carrying out the method of the invention. In the equipment used in the experiment, the rotating roll 1 has a diameter of approximately 10
It is made of steel and has a length of about 1 m.
気泡を含む膏体６を収容するホッパー２は塩ビ板でつく
り、その内側にロール１に沿ってドクターナイフ３を取
り付けである。ドクターナイフ３は厚さ０．２龍の鋼板
で、スリット幅調節ねじ４によりスリット幅を調節でき
るようにしである。脱泡された膏体をロール１から掻き
取るスクレーパー５は厚さ０．２１の鋼板を使用した。A hopper 2 containing a plaster 6 containing air bubbles is made of a vinyl chloride board, and a doctor knife 3 is attached along the roll 1 inside the hopper 2. The doctor knife 3 is made of a steel plate with a thickness of 0.2 mm, and the slit width can be adjusted using a slit width adjustment screw 4. As the scraper 5 for scraping the defoamed plaster from the roll 1, a steel plate with a thickness of 0.21 mm was used.
この装置を使って行った実験を以下の実施例に示す。実
施例中「部］とあるは重量による。Experiments conducted using this device are shown in the Examples below. In the examples, "parts" are based on weight.
実施例１
サリチル酸メチル０．２部、ｌ−メントール０．８部、
ハツカ油０．８部、チモール０．４部、グリセリン２０
．０部およびポリソルベート８０１．０部を混合溶解し
た後、ポリアクリル酸ナトリウム５．０部、酸化亜鉛１
５．０部、酸化チタン３．０部を添加練合し、次いで精
製水４５．８部にゼラチン８．０部を溶解した溶液を加
え、練合した。この膏体をそのまま支持体上に展延する
と小気泡が多数見られた。Example 1 0.2 part of methyl salicylate, 0.8 part of l-menthol,
Peppermint oil 0.8 parts, thymol 0.4 parts, glycerin 20 parts
．． After mixing and dissolving 0 parts of polysorbate and 801.0 parts of polysorbate, 5.0 parts of sodium polyacrylate and 1 part of zinc oxide.
5.0 parts of titanium oxide were added and kneaded, and then a solution of 8.0 parts of gelatin dissolved in 45.8 parts of purified water was added and kneaded. When this paste was spread as it was on a support, many small bubbles were observed.
−万事膏体を図示した装置に入れ、ドクターナイフのス
リット幅を０．２１に調節して回転すると、膏体はドク
ターナイフを通過してスクレーパーによって掻き取られ
る。掻き取った膏体は表面が波状でロールの回転ととも
に集積される。膏体表面の波形は集積量が増大すると多
少変化するが下層への移行は認められず、従って再気泡
形成はなく、展延すると全く気泡は認められなかった。- When the plaster is placed in the illustrated device, the slit width of the doctor knife is adjusted to 0.21 and rotated, the plaster passes through the doctor knife and is scraped off by the scraper. The scraped plaster has a wavy surface and accumulates as the roll rotates. The waveform on the surface of the plaster changed somewhat as the amount of accumulation increased, but no migration to the lower layer was observed, so no bubbles were formed again, and no bubbles were observed when it was spread.
実施例２
サリチル酸メチル０．５部、チモール０．１部、グリセ
リン２０．０部およびポリソルベート８０１．０部を混
合／８解した後、ポリアクリル酸ナトリウム５．０部、
カオリン２５４０部、酸化チタン２．０部、カルボキシ
ビニルポリマー１．０部、トウガラシュキス０．２部、
ザンシン末０．１部およびオオバク末０．２部を添加練
合し、次いで精製水３６．９部にゼラチン８．０部を溶
解した溶液を加え均一に練合して得られた膏体を展延す
ると、多数の小気泡が分布している。本膏体を図示した
装置に入れ、実施例１と同様に処理すると気泡は全く認
められなかった。Example 2 After mixing/dissolving 0.5 part of methyl salicylate, 0.1 part of thymol, 20.0 parts of glycerin and 801.0 parts of polysorbate, 5.0 parts of sodium polyacrylate,
2,540 parts of kaolin, 2.0 parts of titanium oxide, 1.0 part of carboxyvinyl polymer, 0.2 parts of capsicum kiss,
Add and knead 0.1 part of Zanthin powder and 0.2 part of Macaroniella powder, then add a solution of 8.0 parts of gelatin dissolved in 36.9 parts of purified water and knead uniformly to obtain a paste. When it spreads, many small bubbles are distributed. When this paste was placed in the illustrated apparatus and treated in the same manner as in Example 1, no air bubbles were observed.
実施例３
サリチル酸メチル１．０部、ｐ−メントール１．０部、
ａ−カンフル０．８部、ハツカ油０．８部、チモール０
．４部、グリセリン１２．０部およびポリソルベート８
０１．０部を混合溶解した後ポリアクリル酸ナトリウム
３．０部、カオリン４３．０部、酸化チタン１，０部を
添加練合し、次いで精製水３０．９９部にマレイン酸ク
ロルフェニラミン０．０１部、ポリビニルピロリドン２
．０部およびアラビヤゴム未３．０部を溶解した溶液を
加え、均一に練合して得られた膏体を展延すると小気泡
が分布している。Example 3 1.0 part of methyl salicylate, 1.0 part of p-menthol,
a- Camphor 0.8 part, Peppermint oil 0.8 part, Thymol 0
．． 4 parts, 12.0 parts of glycerin and 8 parts of polysorbate.
After mixing and dissolving 1.0 parts of sodium polyacrylate, 43.0 parts of kaolin, and 1.0 parts of titanium oxide were added and kneaded, and then 30.99 parts of purified water was mixed with 0.0 parts of chlorpheniramine maleate. .01 part, polyvinylpyrrolidone 2
．． A solution containing 3.0 parts of gum arabic and 3.0 parts of gum arabic was added and kneaded uniformly. When the paste obtained was spread, small air bubbles were distributed.
本膏体を図示した装置に入れ、実施例１と同様に処理す
ると気泡は全く認められなかった。When this paste was placed in the illustrated apparatus and treated in the same manner as in Example 1, no air bubbles were observed.
上記実施例において、ドクターナイフとロール表面の間
隔は０．２ 璽＊に設定して実施したが、膏体成分、処
理量、気泡の大きさ等に応じてこの間隔は適宜調節する
ことができる。In the above examples, the distance between the doctor knife and the roll surface was set to 0.2 mm*, but this distance can be adjusted as appropriate depending on the plaster components, the amount of treatment, the size of the bubbles, etc. .
また本発明の方法はパップ剤の膏体の脱泡処理のみなら
ず、硬膏、軟膏、クリーム等にも応用できることはいう
までもない。It goes without saying that the method of the present invention can be applied not only to the defoaming treatment of plasters of poultices, but also to plasters, ointments, creams, and the like.
図面は本発明を実施するための装置の概略図である。１
は回転ロール、２はホッパー、３はドクターナイフ、４
はそのスリット幅調節ねし、５はスクレーパー、６は気
泡を含んだ膏体である。The drawing is a schematic diagram of an apparatus for implementing the invention. 1
is a rotating roll, 2 is a hopper, 3 is a doctor knife, 4
5 is a scraper, and 6 is a plaster containing air bubbles.
Claims (1)
高粘度膏体を支持体に展延する前に、該膏体を回転ロー
ルと、該回転ロール表面と微小間隔を形成するように設
置した静止ドクターナイフとの間に形成されたスリット
を通過させることによって膏体に含まれる気泡を潰して
除去した後、脱泡された膏体を前記回転ロールから掻き
取ることを特徴とするパップ剤等の高粘度膏体の脱泡方
法。Before spreading a highly viscous plaster, such as a poultice containing bubbles, obtained by kneading predetermined ingredients onto a support, the paste is placed on a rotating roll, and a minute gap is formed with the surface of the rotating roll. The plaster is passed through a slit formed between the plaster and a stationary doctor knife installed in such a manner to crush and remove air bubbles contained in the plaster, and then the defoamed plaster is scraped off from the rotating roll. A defoaming method for high viscosity plasters such as poultices.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28747786A JPS63139122A (en) | 1986-12-02 | 1986-12-02 | Defoaming of high-viscosity plaster such as cataplasma or the like |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28747786A JPS63139122A (en) | 1986-12-02 | 1986-12-02 | Defoaming of high-viscosity plaster such as cataplasma or the like |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63139122A true JPS63139122A (en) | 1988-06-10 |
Family
ID=17717845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28747786A Pending JPS63139122A (en) | 1986-12-02 | 1986-12-02 | Defoaming of high-viscosity plaster such as cataplasma or the like |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63139122A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0434829U (en) * | 1990-07-04 | 1992-03-24 | ||
| CN106216165A (en) * | 2016-08-29 | 2016-12-14 | 贵州苗仁堂制药有限责任公司 | Babu cream coated and molded machine |
-
1986
- 1986-12-02 JP JP28747786A patent/JPS63139122A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0434829U (en) * | 1990-07-04 | 1992-03-24 | ||
| CN106216165A (en) * | 2016-08-29 | 2016-12-14 | 贵州苗仁堂制药有限责任公司 | Babu cream coated and molded machine |
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