JPS6312843B2 - - Google Patents
Info
- Publication number
- JPS6312843B2 JPS6312843B2 JP54116716A JP11671679A JPS6312843B2 JP S6312843 B2 JPS6312843 B2 JP S6312843B2 JP 54116716 A JP54116716 A JP 54116716A JP 11671679 A JP11671679 A JP 11671679A JP S6312843 B2 JPS6312843 B2 JP S6312843B2
- Authority
- JP
- Japan
- Prior art keywords
- ulcer
- acetylcarnosine
- peptic
- ulcers
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 claims description 15
- 208000008469 Peptic Ulcer Diseases 0.000 claims description 13
- 108700016464 N-acetylcarnosine Proteins 0.000 claims description 9
- BKAYIFDRRZZKNF-VIFPVBQESA-N N-acetylcarnosine Chemical compound CC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 BKAYIFDRRZZKNF-VIFPVBQESA-N 0.000 claims description 9
- 229940124597 therapeutic agent Drugs 0.000 claims description 9
- 208000011906 peptic ulcer disease Diseases 0.000 claims description 8
- 208000025865 Ulcer Diseases 0.000 description 12
- 231100000397 ulcer Toxicity 0.000 description 12
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 8
- 241000700159 Rattus Species 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 3
- 108010087806 Carnosine Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 3
- 229960001138 acetylsalicylic acid Drugs 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 3
- 229940044199 carnosine Drugs 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 206010042220 Stress ulcer Diseases 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 239000003699 antiulcer agent Substances 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 208000000718 duodenal ulcer Diseases 0.000 description 2
- 230000002857 effect on ulcer Effects 0.000 description 2
- 230000000762 glandular Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 229960001660 histamine phosphate Drugs 0.000 description 2
- ZHIBQGJKHVBLJJ-UHFFFAOYSA-N histamine phosphate Chemical compound OP(O)(O)=O.OP(O)(O)=O.NCCC1=CNC=N1 ZHIBQGJKHVBLJJ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 229940067131 aspirin 100 mg Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000138 effect on histamine Effects 0.000 description 1
- 230000001814 effect on stress Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000003715 limbic system Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000002417 xiphoid bone Anatomy 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11671679A JPS5640613A (en) | 1979-09-13 | 1979-09-13 | Novel type remedy for peptic ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11671679A JPS5640613A (en) | 1979-09-13 | 1979-09-13 | Novel type remedy for peptic ulcer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5640613A JPS5640613A (en) | 1981-04-16 |
| JPS6312843B2 true JPS6312843B2 (US07534539-20090519-C00280.png) | 1988-03-23 |
Family
ID=14694033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11671679A Granted JPS5640613A (en) | 1979-09-13 | 1979-09-13 | Novel type remedy for peptic ulcer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5640613A (US07534539-20090519-C00280.png) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5655378A (en) * | 1979-10-12 | 1981-05-15 | Nippon Chemiphar Co Ltd | N-(b-(n'-acylamino)propionyl)histidine aluminum salt and its preparation |
| JPH02229510A (ja) * | 1989-03-02 | 1990-09-12 | Kikkoman Corp | 濾過機 |
| IT1270905B (it) * | 1993-10-15 | 1997-05-13 | Bruschettini Srl | Composizioni farmaceutiche contenenti n-acetilcarnosina per il trattamento della cataratta |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54116717A (en) * | 1971-01-20 | 1979-09-11 | Nordson Corp | Control circuit |
-
1979
- 1979-09-13 JP JP11671679A patent/JPS5640613A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54116717A (en) * | 1971-01-20 | 1979-09-11 | Nordson Corp | Control circuit |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5640613A (en) | 1981-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4016268A (en) | Method of combatting gastric ulceration | |
| JPS59196877A (ja) | チアゾリジン誘導体 | |
| US4038416A (en) | Pharmaceutical composition and method of the use thereof | |
| JPS59485B2 (ja) | エチニルベンゼン化合物の製造方法 | |
| JPS6229566A (ja) | 新規グアニジノメチル安息香酸誘導体 | |
| US5109025A (en) | Therapeutic agent for penal disorders | |
| JPS58159489A (ja) | ２，３−ジアリ−ル−５−ハロチオフエン化合物 | |
| JPS6312843B2 (US07534539-20090519-C00280.png) | ||
| JPH0148254B2 (US07534539-20090519-C00280.png) | ||
| US4127671A (en) | P-acetamidophenyl diethylaminoacetate | |
| US4010274A (en) | Isoindoline derivatives having platelet anti-aggregating activity | |
| SU1356959A3 (ru) | Способ получени кристаллического (4,5,6R,8R)метилового эфира 9-оксо-11 @ ,15 @ -Дигидрокси-16-фенокси-17,18,19,20-тетранорпроста-4,5,13/Е/-триеновой кислоты | |
| US3746495A (en) | Anti-ulcer therapy | |
| US3143469A (en) | Anti-cholesterol nicotinic acid nu-oxide | |
| JPS6312844B2 (US07534539-20090519-C00280.png) | ||
| JPS6310701B2 (US07534539-20090519-C00280.png) | ||
| US3060090A (en) | Pyrazolidine-quinazolone therapeutic composition | |
| US3995055A (en) | Method for treating peptic ulcers | |
| US4447437A (en) | Pharmaceutical composition and method for treatment of peptic ulcer | |
| US4867737A (en) | Derivatives of 4-phenyl-4-oxo-2-butenoic acid their preparation process, their use as medicaments and compositions containing them | |
| JPS6328885B2 (US07534539-20090519-C00280.png) | ||
| US4478845A (en) | Antiinflammatory and/or analgesic imidazoimidazoles | |
| US3708581A (en) | Anti-inflammatories | |
| US3155579A (en) | Therapeutic composition for the treatment of disturbances of the water metabolism characterized by an insufficient elmination of water | |
| JPS5914449B2 (ja) | 抗かいよう剤 |
