JPS6311942Y2 - - Google Patents

Description

[Detailed Description of the Invention] This invention relates to a mucosal bandage, and relates to the structure of a mucosal bandage that is used by being attached to the mucosal surface of a body cavity such as the oral cavity or nasal cavity by the action of secretions within the body cavity.

Mucosal surfaces in body cavities such as the oral cavity and nasal passages are generally soft and highly motile.

Also, since it is constantly moistened with secretions such as saliva, its surface is constantly being washed.

For this reason, it is extremely difficult to continuously administer drugs to the mucosal surfaces of body cavities and to protect wounds and inflammation caused in the mucous membranes.

Recently, preparations aimed at increasing drug retention and pharmacological effects on mucosal surfaces such as the oral cavity have been devised and used (Japanese Patent Application Laid-Open No. 54-41320, JP-A No. 57-58615, Special Publication No. 56-25210, Special Publication No. 56-
No. 27491).

These preparations contain a drug therein, and most take advantage of the fact that water-soluble polymeric substances exhibit adhesive properties when dissolved or swollen in water.

However, mucosal bandages for the purpose of covering and protecting wounds and inflammation, or for fixing arbitrary drugs on mucosal surfaces, have not been studied much, and currently there are none that have been put to practical use. be.

This is because mucosal bandages used for mucosal surfaces in body cavities not only have the ability to adhere to wet surfaces for a long time, but also have flexibility and coverage that allow them to adhere well to surfaces with complex shapes and high mobility. This is thought to be because sufficient toughness is required for protection, but it is difficult to have both of these properties.

The purpose of this invention is to provide a mucosal bandage that satisfies the above-mentioned conditions and has great practical effects.

That is, this device is a mucosal bandage that adheres to and covers a moist mucous membrane, and is made of a flexible and air-containing large number of air-containing particles of a water-soluble polymeric substance that exhibits adhesive properties when dissolved or swollen in water. The present invention relates to a mucosal bandage characterized by strong film surfaces or interiors that exist independently without contacting each other.

In the mucosal bandage according to this invention, among the above-mentioned requirements for a bandage, long-term adhesion to wet surfaces is achieved by containing air in a water-soluble polymer substance that exhibits adhesive properties when dissolved or swollen in water. The small particles are responsible for this, and the film is responsible for covering properties, flexibility, and toughness. Furthermore, since the large number of small particles of water-soluble polymeric material containing air exist independently on the surface or inside of the film without contacting each other, the flexibility of the film is not impaired.

In general, it is well known that polymeric substances have a slower dissolution rate in solvents than low molecular weight substances.

In particular, water-soluble polymer substances have a slow dissolution rate, so a method of quickly dissolving them and obtaining a uniform solution is to first disperse the powder in a non-solvent such as alcohol and then pour it into water to dissolve it. It is.

In this way, the dissolution rate of water-soluble polymer substances is slow because they swell in water and turn into gels, or even when dissolved, they have a high viscosity, which slows the diffusion of molecules and causes blocking in powders. This is because only the surface of the powder gels or dissolves while containing air inside, resulting in a so-called joint powder state in which diffusion of the solvent into the interior is significantly suppressed.

This invention was made by utilizing the above-mentioned phenomenon in reverse.

That is, when the small air-containing particles of the water-soluble polymeric substance, which is a component of the mucosal bandage of this invention and exhibits adhesive properties when dissolved or swollen in water, come into contact with a moist mucous membrane, the area near the surface of the small particles becomes sticky due to capillary action. It absorbs secretions and quickly dissolves or forms adhesives, exhibiting adhesive properties, and forms joint powder within the small grains, which significantly suppresses dissolution and exhibits adhesive properties over a long period of time.

In this invention, the appropriate amount of air contained in small particles of water-soluble polymeric material varies depending on the type of polymeric material and the degree of dispersion of air within the particles, but the appropriate volume percentage is 10 to 60%. It is.

This is because if the air content is less than 10%, the absorption by small particles of secreted liquid is slow, the initial adhesion strength is weak, the properties as joint powder are weak, and the adhesion time is shortened, which is undesirable. This is because the mechanical strength of the small particles becomes weaker and it becomes difficult to obtain a stable mucosal bandage.

The shape of the small particles may be any shape such as a sphere, a cylinder, a disk, an ellipsoid, or a rod.

In addition, the larger the particle size of the air-containing water-soluble polymer particles, the longer the adhesion time, and the smaller the particle size, the better the feeling of use. The size may be determined depending on the site of use, purpose, etc. Incidentally, when used on the oral mucosa, it is appropriate that the particle size is about 0.1 to 1.0 mmφ when the shape of the small particles is spherical.

The water-soluble polymeric substance used in the mucosal bandage of this invention may be any substance that dissolves or swells in water and exhibits adhesive properties. Examples of such substances include polyacrylic acid, sodium polyacrylate, and polyacrylate. Acrylic acid polymers or copolymers or their salts such as ammonium acrylate and carboxyvinyl polymer, synthetic products such as polyvinyl alcohol and polyvinylpyrrolidone, methylcellulose, ethylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethyl starch These include semi-synthetic products such as starch, natural products such as sodium alginate, gum arabic, gum tragaganth, and mixtures thereof.

As the film used in this invention, any film can be used as long as it is flexible and strong, regardless of whether it is water-soluble or water-insoluble.

For example, water-soluble films include polyvinyl alcohol, hydroxypropyl cellulose, etc.
Examples of water-insoluble films include polyethylene, polyvinyl chloride, and polyurethane.

Furthermore, when a water-insoluble film is used, there is no permeation of secretions from the back side of the dressing, and therefore a longer dressing time is possible, but on the other hand, the interaction between the small particles and the film is Because of its weak adhesive strength as a bandage, its adhesive strength tends to be weak.

On the other hand, when a water-soluble film is used, the adhesive force as a dressing becomes stronger, but the adhesion time tends to be shorter because secretions permeate from the back side of the dressing.

Next, one embodiment of this invention will be described based on the drawings.

FIGS. 1A, B to 3A, B are a plan view and a side view showing several examples of the basic structure of the mucosal bandage D of this invention.

Figures A and B are configurations that emphasize adhesion between air-containing small particles of a water-soluble polymer substance and mucous membranes, and are suitable when using a water-soluble film 2 that strongly interacts with the small particles 1. . In this case, since there is a slight gap 3 between the film surface 2 and the mucous membrane surface (not shown), it is suitable for use for the purpose of fixing medicine powder.

Figures 2A and 2B are configurations that place emphasis on the adhesion between the small particles 1 and the film 2'; in this case, the film 2' is suitable when using a water-insoluble film that has weak interaction with the small particles 1. ing.

Figure 3 A and B are intermediate forms between Figures 1 and 2;
That is, it shows a form that can satisfy both the adhesion between the small particles 1 and the adhesive and the adhesion between the small particles 1 and the film 2.

However, although the small particles are uniformly distributed on the film in FIGS. 1 to 3, this uniform distribution is not a necessary condition;
As shown in Fig. 5, the small particles 1 may not be present in a certain area 4 of the film 2 of the dressing D, and such a dressing A may be used when the wound area is particularly sensitive to irritation. It is particularly suitable for locally administering large amounts of drugs.

In addition, in the mucosal bandage of this invention, the film 2 may have two layers 2a and 2b, or more than two layers, as shown in FIG. film layer 2
By providing b thinly, both strong adhesive force and long-term drug retention can be satisfied at the same time.

The small particles of the water-soluble polymeric substance, which are the constituent elements of the mucosal bandage of this invention, can be obtained by compressing, thermocompressing, or, in some cases, compressing in a wet state, powders of appropriate particle size.

Further, a mucosal bandage having the small particles can be obtained by press-bonding or thermocompression bonding the small particles and a film, or by press-bonding the small particles and a film in a wet state.

In addition, it is also possible to form a mucosal bandage all at once by compressing polymer powder powder spread in a pattern on a film. In short, the mucosal bandage of this invention has small particles that exist independently, so
The flexibility of the bandage is not compromised. That is, since small particles of water-soluble polymers generally do not have flexibility, if small particles are present on the film or inside the film in contact with each other, even if the film is flexible, the small particles will prevent the film from deforming. It becomes less flexible and loses its properties as a bandage. However, when the small particles exist independently without touching each other as in this invention, the flexibility of the film is maintained sufficiently due to the presence of gaps.

This invention will be explained below using examples.

Example 1 Polyvinyl alcohol powder with an average degree of polymerization of 1600 is compression molded to obtain disc-shaped small particles with a diameter of 2 mm and a thickness of 500 μm and an air content of 40%. 100 of these small grains,
It is placed as shown in Figure 1 on a polyvinyl alcohol film (thickness = 100 μm) with an average degree of polymerization of 1600 containing 10% glycerin, and adhered under pressure under humidified conditions. The mucosal bandage of the present invention shown in Figure 1 was obtained.

When the bandage was applied to the buccal mucosa of 10 panelists, it adhered well for an average of 40 minutes.

Example 2 A carboxyvinyl polymer is pressure molded to obtain a sheet with an air content of 60% and a thickness of 100 μm. This sheet is crushed and passed through a sieve with a pore size of 1 mm to obtain irregularly shaped small particles. These small particles were scattered on a vinyl acetate resin film with a thickness of 200 μm and an average degree of polymerization of 800 so as to cover about 50% of the area, and pressed at 50°C to embed the small particles in the film, as shown in Figure 2. A mucosal bandage of the present invention as shown was obtained.

The bandage was cut into a 10 mm x 10 mm rectangle and applied to the front surface of the upper gums of 10 panelists.
Good adhesion was achieved over 60 minutes.

Example 3 Sodium polyacrylate 3g, sodium carboxymethylcellulose 6g, glycerin 10
g and 30 g of water was cast onto a polyester film and dried to obtain a film with a thickness of 100 μm. Collodion is applied to one side of this film and dried to obtain a flexible film. Cover the other side with a plastic film with 100 circular holes with a pore size of 0.5 mm ^per square centimeter, and add 10 mg of hydroxypropyl cellulose powder ^per square centimeter over the plastic film.
After spraying, the plastic film is removed and patterned spraying is performed. This was pressed at 100°C to form half-embedded small particles to obtain the mucosal bandage of the present invention shown in FIG.

The bandage was cut into a circle with a diameter of 20 mm and applied to the inner surface of the upper jaw of 10 panelists, and the bandage adhered well for an average of 110 minutes.

[Brief explanation of the drawing]

Figures 1A and B are plan views and side views showing basic configuration examples of the mucosal bandage of this invention, and Figures 2A and B and Figures 3A and B are plan views showing other configuration examples. A side view, FIGS. 4 and 5 are plan views showing other examples of the distribution of small particles of polymer material on the film in the mucosal bandage of this invention, and FIG. 6 is a mucosal bandage with two film layers. FIG. 1...Small particles containing air made of a water-soluble polymer substance, 2...Film.

Claims (1)

[Scope of Claim for Utility Model Registration] (1) A mucosal bandage that adheres to moist mucous membranes to cover and protect the mucous membranes, which contains air of a water-soluble polymer substance that exhibits adhesive properties when dissolved or swollen in water. A mucosal bandage characterized by a large number of small particles existing independently on the surface or inside of a flexible and strong film without touching each other. (2) Air content in small particles made of a water-soluble polymer substance that exhibits adhesive properties when dissolved or swells in water is 10
60%.