JPS6289613A - Rhyparia detector - Google Patents

Abstract

PURPOSE:A phyparia detector that contains 2,6-dichloroindophenol as a pigment for staining rhyparia, thus being capable of staining rhyparia with bright color and being readily decolorized in oral mucosa which have been undesirably stained with a reductive decoloring agent. CONSTITUTION:A phyparia detector that contains a compound of formula I (X is H, alkali metal, ammonium, monotriethanolamine) or is composed of the first agent for staining rhyparia, which contains the compound of formula I and of the second agent of a reductive decolorizing agent, preferably ascorbic or erysorbic acid or their water-soluble salt, preferably a compound of formula II and its salt. Since the detector can clearly stain rhyparia, the distribution can be readily seen and it can be easily removed by brushing. Further, the stains which cannot be removed by brushing, such as stained mucosa, are readily removed with the second agent.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a dental plaque determining agent.

[Conventional technology]

Dental plaque is the accumulation of oral bacteria, salivary mucin, peeled mucosal epithelium, food residue, etc. on the tooth surface, and is known to be a cause of tooth decay and periodontal disease. Removing dental plaque is the most important thing for oral hygiene.

Now, the most commonly used method for removing plaque is brushing with a toothbrush.
Tooth surfaces are extremely uneven, and plaque adhering to tooth surfaces is a translucent sticky substance that is difficult to see with the naked eye. Therefore, there are various ways to thoroughly remove plaque with brushing. We have to come up with some ideas. One such technique is to stain the plaque with a dye such as erythrosin before brushing and remove the plaque by brushing while checking the area where the plaque has adhered, which is extremely effective.

[Problem that the invention seeks to solve]

However, the dyes currently used for staining dental plaque include, for example, erythrosin, basic tsuksin, and gentian purple, but these dyes stain oral mucus as well as dental plaque. Moreover, it is difficult to decolorize the stained mucous membrane in a short period of time, so after staining plaque and brushing, you will have to put up with an unsightly appearance such as the inside of your mouth turning bright red for a while. If you don't do it, you won't be able to do it. For this reason, many people hesitate to use plaque staining agents, even though they are extremely effective.

[Means for solving problems]

Therefore, the present inventors conducted intensive research to solve such problems with conventional dental plaque determining agents, and as a result, we found that when 2゜6-dichloroindophenol is used as a staining dye for dental plaque, Being able to dye stains more clearly,
Furthermore, they discovered that by using a reducing decolorizing agent, the mucous membranes of the oral cavity and the like stained with the above dyes can be very easily decolorized and restored to their original color tone, and have completed the present invention.

Therefore, the first aspect of the present invention provides a dental plaque determining agent containing 2,6-dichloroindophenol.

Further, a second aspect of the present invention provides a plaque determining agent comprising a first agent for staining plaque containing 2,6-dichloroindophenol and a second agent for decolorizing containing a reducing decolorizing agent. .

2,6-dichloroindophenol used in the present invention is a substance represented by the following general formula (I), and can be used in the same manner as its salts.

j (wherein, X represents a hydrogen atom, an alkali metal, ammonium, or mono-, zo-, or triethanolamine) The amount of 2.6-dichloroindophenol added to the plaque determining agent is 0.5 to 95% by weight You can choose from a range of whispers.

The dosage form of the dental plaque determining agent containing 2.6-dichloroindophenol is liquid, lotion, paste, powder,
Examples include granules and tablets.

When preparing these dosage forms, 2,6-dichloroindophenol is quickly and uniformly dispersed in the oral cavity,
It is also desirable to add a surfactant in order to allow the pigment to penetrate deep into the dental plaque. The surfactant may be anything that is acceptable for use in the oral cavity, such as water-soluble salts of alkyl sulfate esters in which the alkyl group has 8 to 24 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate; monolauryl phosphate; Water-soluble salts of monoalkyl phosphate esters in which the alkyl group has 8 to 24 carbon atoms, such as sodium or sodium 7-point Q lumityl phosphate; 10
-24 Water-soluble salts of N-acylamino acids: sucrose mono- and dilaurate, etc., in which the number of carbon atoms in the fatty acid group is 10-1
8, sucrose fatty acid ester; lactose fatty acid ester, sorbitan I fatty acid ester, ? Fatty acid monoglyceride whose fatty acid group has 10 to 24 carbon atoms, such as lioxyethylenesolhitan fatty acid ester and stearic acid monoglyceride; Is the fatty acid group such as lyoxyethylene lauric acid ester having 10 to 24 carbon atoms? Lioxyethylene (10 to 100 mol) fatty acid ester; Alkylamine oxides in which the alkyl group has 10 to 18 carbon atoms, such as laurylamine oxide; Water-soluble salts; water-soluble salts of alkylpencylammonium, water-soluble salts of alkylpyridinium, water-soluble salts of bispiguanides such as chlorhexidine hydrochloride; Examples include betaine and alkylimidazolinium.

Further, in order to improve the feeling of use, it is desirable to incorporate appropriate sweeteners such as saccharin sodium, stevioside, Asno-Q luteme, No-Q latinose, glycyrrhizinates, licorice extract, etc., and appropriate flavors.

Further, the second invention of the present invention is to decolorize the gingival mucosa etc. stained with the first agent for plaque staining containing 2,6-dichloroindophenol with the second decolorizing agent containing a reducing bleaching agent. be.

The decolorizing agent used in the second decolorizing agent must be a reductive decolorizing agent since good results cannot be obtained with an oxidative decolorizing agent. Examples of reductive decolorizing agents include ascorbic acid, erythorbic acid, sulfite, thiosulfate, metabisulfite, and water-soluble salts thereof, and water-soluble salts include ammonium salts, ethanolamine salts, sodium salts, potassium salts, and lithium salts. Examples include alkali metal salts such as Among these reductive decolorizing agents, ascorbic acid, erythorbic acid, and water-soluble salts thereof are preferred, and in particular, the following formula (II), HsOH (wherein, X is a hydrogen atom, an alkali metal atom, an ammonium group, or Ascorbic acid and its salts represented by (representing ethanolamine) are preferred.

The amount of the reduction decolorizing agent added to the second decolorizing agent is more effective, but it can be selected within the range of 0.5 to 95% by weight.

The dosage form of the second decolorizing agent is preferably powder, granules, or tablets in which the reducing decolorizing agent is in a form that is not susceptible to oxidation. A preferred method is to put the drug directly into the mouth and dissolve it in saliva.

It is also desirable to add an appropriate sweetener or flavor to the second decolorizing agent for the purpose of improving the feeling of use.

By using this second decolorizing agent, it becomes possible to very easily remove the coloring of the oral mucosa, etc., which cannot be removed by brushing or the like.

[Action and effect of invention]

The dental plaque determining agent containing 2,6-dichloroindophenol of the present invention clearly stains dental plaque, making it easy to determine the state of plaque adhesion, making it easier to remove plaque by brushing. . In addition, the oral mucosa that is unnecessarily stained is easily decolorized by the second decolorizing agent containing a reducing decolorizing agent.

〔Example〕

Next, the present invention will be explained with reference to Examples.

Example 1 Dental plaque determining agent 2.6-dichloroindophenol sodium 2.0
Weight polylauryl sulfate ester sodium salt 0
．． 1 Saccharin Sodium 0.05 Flavor 0.1100.0! jt% The above ingredients were mixed and compressed into tablets. When I put this in my mouth, chewed it, applied it to the tooth surface using my tongue, and rinsed it with tap water, it was confirmed that the plaque was stained purple.

Example 2 Plaque determination agent 2.6-dichloroindophenol potassium 1.0 weight - glycerin 5.0 Pluronic type surfactant 0.1 [Emulgun PP250 (chemical soap ■)] Saccharin sodium 0.05 flavor
0.05 Purified water The above ingredients were mixed and stirred to form an aqueous solution. When a cotton swab was impregnated with this and applied to the tooth surface, water was then passed through the mouth, and it was confirmed that the dental plaque was stained purple.

Example 3 (First agent) 2.6-dichloroindophenol ammonium 1.
0]ii% Glycerin 5.0 Sodium carboxymethylcellulose 2.0 Monolauryl phosphate ester sodium salt 0.2 Silicic anhydride 5.0 Stevioside 0.1 Flavor
0.1 total 100.0 weight - (2nd agent) Ascorbic acid 10.0 weight - Sodium ascorbate 15.0 Asuno Q Luteme 1.0 Flavor
0.1 mannite needle 100.0 weight - The above first agent components were kneaded and stirred to form a paste. When I put this on a toothbrush, applied it to the tooth surface, and then rinsed it with tap water, it was confirmed that the plaque was stained purple. This staining remained on the oral mucosa and residual dental plaque even after brushing, but when the second agent lft-100sd was dispersed and dissolved in water and used as a mouthwash and was poured into the oral cavity, the coloring of the oral mucosa and dental plaque The coloring was also easily bleached.

that's all

Claims (1)

[Scope of Claims] A dental plaque determining agent containing 1,2,6-dichloroindophenol. A dental plaque determining agent comprising a first agent for staining plaque containing 2,2,6-dichloroindophenol and a second agent for decolorizing containing a reducing decolorizing agent.