JPS6281315A - Remedy for bacterial dermatosis such as athlete's foot - Google Patents

Abstract

PURPOSE:To provide the titled remedy containing a specific compound as active component having vitamin B1 activity, penetrable deep into the skin, decomposable in the body to form a strong microbicidal substance and free from side effect such as skin irritation, development of red spot, etc. CONSTITUTION:The compound of formula (R1 is methyl, ethyl, propyl, etc.; R2 is methyl, ethyl, allyl, etc.), its hydrochloride or nitrate is used as a remedy for bacterial dermatosis such as athlete's foot. The compound of formula is decomposed into thiamine and an alkyl sulfide in the body to exhibit strong microbicidal effect and imparts strong effect against the microorganism living in the deep part of the skin. The compound of formula is an epoch-making remedy having chemical stability, free from side effect such as skin irritation or development of red spot and acting as a useful vitamin B1 when absorbed in the body.

Description

DETAILED DESCRIPTION OF THE INVENTION Bacterial skin diseases such as athlete's foot are extremely difficult to cure because bacteria grow deep within the skin, and there is currently no definitive treatment. As a result of many years of research, the inventor of the present invention has succeeded in developing a therapeutic drug 011 that has an epoch-making effect.

The therapeutic agent according to the present invention is represented by the following general formula.

Here, R+ is a methyl group, ethyl group, propyl group, and R2 is a methyl group, ethyl group, propyl group, allylfurfuryl U.
Yes, this compound is a vitamin 81 active substance,
Although it does not have much bactericidal power as it is, its mechanism of action is that it is well absorbed into the skin and decomposed in the body to produce thiamine and alkyl sulfide, which is thought to exert a strong bactericidal effect. Therefore, according to the present invention, it is thought that it can penetrate well into 17 parts of the skin and exert a strong effect on bacteria deep inside. This compound is chemically stable and has 2. I
Do J! 11 does not cause any harmful effects such as severe redness, is not toxic even if absorbed, and is an innovative treatment for athlete's foot, etc., which acts as a vitamin/B1 for IJ''.

Details of therapeutic effects and the like will be explained in Examples.

Example = 1 One part of thiami/ethyl disarefider, a compound of the general formula in which R1 is a methyl group and R2 is an ethyl group, was thoroughly kneaded with hydrophilic petrolatum (pharmacopoeia) to prepare a therapeutic agent. 1 g of this was applied to the four parts of the right foot of each of five male subjects. Hydrophilic petrolatum 719 was applied to the left foot, which was affected by athlete's foot to the same extent. One patient's right leg was completely cured after applying the therapeutic agent of the present invention three times, and three patients were completely cured after applying Milo. The left foot, which was only treated with hydrophilic Vaseline, had no effect even after applying Milo. At the same time, a batch test was conducted by applying it to the upper calf of the left arm, but no redness or other abnormalities were observed in any of the patients. The second and subsequent applications were carried out every 24 hours, and judgment was made 24 hours after application.

Example 2 Example of a compound in which R1 is an ethyl group and R2 is a propyl group
The same test was conducted in the same manner as in No. 1, and almost the same results were obtained.

Example 3 Example of a compound in which R1 is a methyl group and R2 is an allyl group
As a result of testing with the same treatment as 2, substantially the same results were obtained.

Example-4 05 parts of the same compound as Example-3, hydrophilic petrolatum/995
The skin was treated in the same way as in Example 1 (*) and as a result of the test, 4 people were completely cured after applying it twice, and 6 people after applying it 3 times.

Claims (1)

[Claims] A therapeutic agent for bacterial skin diseases such as athlete's foot containing a compound represented by the following general formula as an active ingredient ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ Here, R_1 is a methyl group, an ethyl group, a propyl group. group, butyl group, R_2 represents a methyl group, ethyl group, propyl group, allyl group, or furfuryl group. Also included are hydrochloride and nitrate salts of the present compound.